4 Factors that Clear Plaque in your Arteries
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- Опубліковано 26 бер 2024
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References (Copy & Paste DOI into Search)
[1] doi:10.1016/j.yexmp.2017.01.013
[2] doi:10.1093/eurjpc/zwac309
[3] doi:10.1161/CIRCULATIONAHA.109.879254
[4] doi:10.1016/j.tcm.2018.05.002
[5] doi:10.1016/j.amjcard.2014.08.012
[6] doi:10.3389/fphys.2023.1043108
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NOTE: [Video Summaries and Chapters] I spent 350$ and 5 weeks of work to make this free video. Video summaries and chapters on an 11 minute video hurt retention and hurt the video performance, therefor hurting the channel and my ability to continue this work. If you do not think it is worth your 11 minutes to watch the video and all its context, I understand; however, I ask you understand where I'm coming from, as well. In such a case, I think this brand is not for you - there are plenty of pop science channels to follow - this channel is dedicated to the people who want the depth and context (I appreciate you). So, in short, please do not post video summaries (see channel rules). Thank you. :)
Much appreciated bro , I’m just kidding big fan !
Good morning. I've been watching a video in which Dr Malcolm Kendrick considers an alternative model of what causes arterial plaques, and what things allow them to regress: watch?v=wRjQCG4NU-Y Malcolm also mentions in the video how this alternative model, though acknowledged by a greater proportion of medics and researchers than might appear, continues to be suppressed. I'd be interested in your thoughts and critique of the model, and expect that you and other viewers of yours would be too.🤓 Kind thanks.😊
To summarize your anti-video summary comment:
Watch the entire video, start to finish, so that UA-cam pays him for his work. Don't post video summaries in comments that might cause potential viewers to leave the video before having viewed the whole thing.
Did I get that right? Did I miss anything?
Thanks for the excellent content as always!
You need other sources of income it seems, outside of UA-cam...
@@src3360You missed the point. This video cost him a lot of time, and some money, regardless of any other factors. What do you do for free on a regular basis to benefit other people who can probably afford to pay you?
Berberine / metformin
Nattokinase / serrapeptase
K2 / koncentrated K
Omega 3s / Astaxanthin
Magnesium glycinate
Similar to all your supplements. As well as:
5g VitC, and several other anti oxidents like pine bark and aged garlic, tumeric etc, as well as tocotrienols
Ty😅
No one taking Niacin? I added niacin because Dr Ford? Says it’ll help. I switch between flush niacin and non flush niacin.
Make yourself Chemical Ali... avoid excersise at all costs, take chemicals only :D
@@davex142 I for one am unable to exercise properly. Disabled, I’ve had a couple back surgeries and a foot reconstruction from a gunshot wound.
Bonus factor:
High speed motor racing
... lowering your risk of dying from cardio-vascular problems, by raising the risk of vehicle accidents.
Imagine the possibilities of bonus factors.
and yet, Dr Peter Attia (who wrote 'Outlive: The Science & Art of Longevity') engages in it, and Ayrton Senna is his sporting hero! ;-)
😂😂. That's been my strategy for eternal life all along. Risk taking! For 1, you are in control, not other things. When other things see how much you challenge yourself, they say, "I think I'll pick on someone else". #2 Know your limits for max safety, discipline!
😂😂😂😂😂
You got it!
Very impressed with this presentation. No real fluff. Informative and to the point, AND HELPFUL! Thank you!
Walking is a super power
Fasting is a miracle
I love fasting!
@charflorida5433 I hate it. I believe in it. It's not fun. Maybe you can educate me, so I can love it.
I thought fasting's only benefit was reducing calories, and that the actual gap in eating was harmful and put stress on the body. Most doctors recommend eating more often, but smaller amounts.
@@Gothlore No, int fasting is not about reducing calories. It is about reducing insulin production. And it does not need to be done 7 days a week. I personally don't take the advice of most docs anymore. I suffered for decades with IR and all its symptoms, and docs never told me the cure. I found the cure on my own, int fasting. The "stress" on the body is autophagy, which is extremely healing. Most GPs these days are "pharmecutical reps" not health and diet professionals.
@@charflorida5433 It's not just what doctors say. There are plenty of recent studies that show reduced lifespan and plenty of other health issues with fasting.
You're #1 for informative health videos Nick! Thanks for bringing everything together for us.
Great Makeup
Kid
Your videos are one of the few ones I watch, it's so hard to find well-presented science by a person who is also a scientist. I might not be a scientist in the same field, but having an interest in sports science and nutrition, I cringe at what is being shared around the internet usually... So, what I'm saying is, please never stop making videos 😂
Thanks!
Keep looking around, don't stop here.
@@deemisquadis9437 While I'm not sure what you are trying to say, I do follow other authors as well, who I also deem it worthwhile to spend my time on. And if there's something I'm really interested in, I know how to research things myself. But the majority of my time is spent on computer science as that is my vocation, since I'm not made of infinity.
@@Physionic I have also read that high amount of endurance exercise can actually cause atherosclerosis? People like marathon runners and other endurance athletes might actually get plaque from the increased inflammation caused by their high training load afaik. And you could have mentioned things like nattokinase+K2 that at least in one study was able to reduce plaque in higher dosage. I'm also personally interested in the idea of substances like citrulline and AAKG possibly being beneficial in this regard to them increasing nitric oxide leading to better circulation. Might be an idea for another video: evidence of natural suplements/foods that can lower LDL, increase circulation and heart health and perhaps even reverse plaque. Some sustabces that come to mind are:
-AMLA (lowers LDL as much as statins in one study)
-Citrulline, AAKG
-EDTA (chelation)
-Nattokinase, Serrapeptase
-B3
-Pomegranate
-Garlic
-Omega 3
@@Physionic I have also read that high amount of endurance exercise can actually cause atherosclerosis? People like marathon runners and other endurance athletes might actually get plaque from the increased inflammation caused by their high training load afaik. And you could have mentioned things like nattokinase+K2 that at least in one study was able to reduce plaque in higher dosage. I'm also personally interested in the idea of substances like citrulline and AAKG possibly being beneficial in this regard to them increasing nitric oxide leading to better circulation. Might be an idea for another video: evidence of natural suplements/foods that can lower LDL, increase circulation/heart health and perhaps even reverse plaque. Some sustabces that come to my mind are: AMLA, Citrulline, AAKG, EDTA, Nattokinase, K2, Serrapeptase, B3, Pomegranate, Garlic.
Thank you for breaking this down so simply! My father had quadruple bypass surgery in his 60s and I have uncles on my dad's side that never made it into their 40s due to heart disease. This information is life-saving to those who take this information seriously enough to make habitual life-style changes. Thank you!
They may have had Apo A , you may have it too . A new drug has came out to reduce it I believe. Normally is fixed for life
edit mean Lipoprotein (a) - genetically determined and is high risk to a bad cardiac outcomes
What was their lifestyle like?
@@skythundersky1544they probably followed the USDA Food pyramid. Low fat, high carb. 😢
Us life exiectacy is the lowest of advanced 30 countries.
@@nimblegoatDo you mean Apo B?
I was always told K2, Magnesium, Omega 3, D3, Alpha Lipoic Acid, and Vitamin C help clear it. I take them all.
Generally speaking, ,why Im unsubscring from this channel now- , (where he never mentions Tryglicerid is the main problem for this plaques, (carbs) and not LDL which is produced mostly by liver and it is , the main part of lipoprotein mechanism , and it is not cholestrol, it is the carrier to cells..which is MUST for body. and neve rmentions, 2:14 shows `Oxidized LDL` but never mentions what is this and hox oxidization is caused by blood Glucose, :-) , and never mentions Glucose is the root of fat storage mechanism (loose weihgt issue ) so anyway, those supplements are fine, ```but by the way, need to stay away ``mainstream channels` (always told ) to you if mainstream info , is probably showing the wrong direction
@@onder8374 I like your ideas here. Can you prove any of it?
@@onder8374 thanks for the misinformation bro
Excersise Prevents This Plaqing
@@onder8374talk but can't prove when other guy asked, just a talk talk talker
I love that you explain why a logic is correct, and why a logic is mistaken (when it is)
This video is greatly appreciated, thanks so much for the content ❤
Hi Physionic I watched many many video on reversing plaque and this video is the best i.e. most logical and clearly explained !!! I used to be in the research field and I know your explanation is very well justified!!! 💗💗
Clear, Concise. Brilliant stuff. Thank you!
Thanks so much for the information. Great presentation!
Thank you for this information. I value your channel very much and appreciate the effort it takes to create accurate and meaningful content. 💕
I had a stent fitted a couple of months ago as an otherwise active and healthy 53 year old - so finding realistic, evidence based information on recovery and appropriate lifestyle choices has been vital to me. Thank you for sharing this and your channel content in general.
I find the supplement area most challenging as that's where the most 'fake science' and fitness influencer content hangs out - but might make some decisions on those once I've implemented the core recommendations that are consistently made. I've lost ~15% body mass over the last four months, transformed my diet and am slowly building up exercise levels with the help of the Doctors. The hardest part is not being able to directly measure the consequences of these changes since our health service minimises follow up to periodic basic blood tests. I know I'm fitter and lighter, but don't know how far that is benefiting me as someone who has a heart disease diagnosis.
Do you have independent labs where you are? Over here in the States, we have a variety of independent labs (private pay, of course) where we can go and get practically any kind of lab work done, including NMR particle profile tests, etc. It might be worth looking into, they aren't free, but they aren't terribly expensive for a test you'll only need to have performed once or twice a year to keep tabs on your progress.
Had 2 stents fitted a week ago after having a heart infarction aged 53. Sadly nothing was given to me diet related, nothing.
Basic multivitamin works for me, surprisingly after a few months of taking it, caused removal of my old and new nail fungi.😮
Great video and info! Thanks! I love all of your analyses.
Its worth watching more than once because its a lot to digest in one run.
Thank you for this great research info and for sharing it with us! 👍🏻
I am grateful for your work and your talent/gift. Material things are necessary while we live. The intention of why we do things follows us even when we leave here. Doing things with an intention of helping someone guarantees physical provision here and contentment over there.
So great full for your knowledge sharing thanks!!
This subject is crazy interesting and relevant to an ever growing number of people, including me. Please follow up on this!
Thanks, Mark!
Great channel! I’m interested in how you choose a review topic? It’s a great service to you’re performing going through these studies. Thanks!
I very much appreciate your efforts and your videos! Keep up the great work!!!
Fantastic explaination as usual. Many thanks. ❤❤❤
Thank you for all the information 👍🏽
Thank you for this clear, concise helpful information.
This is especially of interest for me as something I worry about, I exercise lots but I also have health anxiety! 😅Thank you!
DAMN!! I’ve watched 100s of health videos (especially after my ❤ attack last year) and NO ONE has explained atherosclerosis and blood pressure as well as this!
To add to my understanding, I’d like to see a discussion on how obesity affects inflammation.
Another absolutely brilliant articulation. From one who spent a lifetime teaching, I want to say, you are truly a master teacher!
You gave an incredibly super remarkably clear bullet-pointed explanation of the atheroma creation and probable reversal process, I have listened to a lot of folks trying to explain it, but I found this to be the clearest of any I can recall, in fact it was so clear it makes me believe that I actually understand the processes of both.
Thanks, Mike. Kind of you to say.
Brilliant Presentation. Clear and informative. Thank you.
Excellent.
Im 64 and I have been looking after my endothelial lining for 6 years.
Starting with the building blocks .
Zinc
Manganese
Copper
I swear its what keeps me cold free.especially with th big C breathing disease
I never got it.
I didn't roll up my sleeve for a needle.
I just took extra vitd3 in winter.
Olive oil and totatal avoidance of canola/rapeseed.
Very very difficult because its in EVERYTHING on the supermarket shelf.
THEN
lots of walking or swimming .swimmings best for not damaging my weak joints and tendons.
I have now stopped drinking by 90 percent.
Same for SUGARS.....thats a proper bad food .
SO GLAD SOMEONE IS TALKING ABOUT THE ENDOTHELIAL.
what also happens when you breathe HARD through your nose is the natural production of the same gas you get from viagra......nitrous
Need i say more.
Caught your conversation with Gabrielle Lyons yesterday . I have been taking creatine for a few weeks now after I saw the information you gave on your show . I just turned 65 🎉. Dr Andrew huberman just asked people who they would like to see having a conversation with him , and I mentioned your name I hope you don't mind 😊!! By the way you have a great sense of humor , and no I'm not giving up my social security number 😊😊 have a beautiful day thank you for all your research !!
I appreciate the kind words - thank you :)
I would love to see this too!🙏🏻
That's a great idea
Id love to see Huberman in conversation with his recent ‘monogamous’ partners about his proclivities, and their sexual health.. but it’ll be hard watching. 💀
Huberman is a quack like most joe roganites
Thanks for the great talk, loved it
Thank you so very much, I appreciate this information so much.
As efflux of LDL (ApoB) into the artery wall is gradient driven, it makes sense BP is an essential component of the process.
I just found and subscribed to your channel because this topic is of great interest to me. At about 3:50 you mentioned that to clear arterial plaque, having low blood LDL is thought to be important. That is my personal primary reason for taking twice monthly injections of Repatha. In a few months I will complete a 78-week regimen. I discovered that early clinical reports are showing that Repatha can cause a reduction of arterial plaque by as much as 20%. When I asked my cardiologist about the reports, he said he knew about them too. When I remarked that this could be a game changer for me, he agreed. My LDL cholesterol has been about 17 for over a year. After a year, my systolic BP dropped from about 125-140 to 100-115. I am hopeful that when I am finished with Repatha my cardiologist can at least semi-quantitively determine if my plaque burden has become lower. And perhaps you can find more current information about the relationship between ultra-low blood LDL and plaque reduction. Thank you for your excellent video.
17 LDL? Is that a typo?
Before Repatha taking 15 mg simvastatin. 1/4/23 Start Repatha 2x/month +10 mg /day simvastatin
1/9/23 LDL 42
3/16/23 LDL 17
8/8/23 LDL 21
11/13/23 LDL 16
I meet medical criteria for taking Repatha so covered by insurance. Plaque reduction not reason it was prescribed. Hope this helps.
@@anode-cathode
@@anode-cathode Not a typo. Over 12 months the numbers were: 1/9/23 - 42, 3/16/23 - 17, 8/8/23 - 21, 11/13/23 - 16, 1/3/24 - 29. You're likely unable to get LDL that low without a PCSK9 inhibitor like Repatha. And my cholesterol has never been high so high LDL patients may not get that low. But PCSK9 plus a statin still will be dramatic.
@@anode-cathodethere are people who have 0 ldl genetically.
@@anode-cathode No. PCSK9 inhibitor. Google it. I hope Nic will leave this reply up long enough for you to see that I did not ignore you. Bye!
Thank you for all your hard work
So great to hear about Atherosclerosis reversal. I was always curious about this as my family has history of it. I myself also had high ldl previous years. What should I do to lower ldl and apoB besides weight lost
LOVE this analysis! Thanks Nic.
Thrilled to hear it :)
Would L-Citrulline or L-Arginine aid in providing nitrous oxide to arteries, as you stated was helpful?
good information. The first thing i check in a video is the length of time. If it is between 1 to 22 minutes , I am incline to watch, anything beyond that has to be something that I am totally interested in and the presentation is captivating. This video was ideal, short , to the point and informative!
One of the great things about podcasts/youtube videos is that, in contrast to broadcast outlets, there is plenty of time to present a true deep-dive. Instead, an option for you might be to limit yourself to 22 minutes (or however long you choose) and then come back later for more and then come back again for even more. This way, you still get the *all of the deep-dive info but spend only as much time as you can or want to spend at a given time. UA-cam/podcasts = such a great way to learn quite detailed info for almost free, yet people ask for shortened videos, which means less detail. Why?? Just watch for 22 minutes and come back later. Deep dive = deeper understanding of complex topics. Well worth whatever extra time true understanding takes.
Brilliant article really enjoyed that thank you
I love the infographics and animation stuff, makes things clear. Also I noticed you've been showing a bit of wit/humour in your videos lately which I think is great, it really breaks the monotony and helps with my short attention span haha.
As for the video, so besides reducing LDL there's no much hope in reducing plaque? Are people on keto diets doomed?
Thanks - I appreciate it. As for your questions - there are some potential additional things, but I'm currently still investigating them, so I'll release more content on them in the future. Keto users are not doomed - it's still possible , in my estimation. One just has to focus on the right types of fats.
Not everybody experiences a rise in LDL on keto diets. According to recent research, the leaner you are the greater the rise in LDL on keto.
Would it make you feel better if keto followers were doomed? Its people eating ultra processed crap fake foods that are doomed and thats sad too.
I periodically take a full spectrum of proteolytic enzymes including 2000 FU of nattokinase per day. Proteolytic enzymes are fibrinolytic, or they break down fibrins, which are proteins that are components of arterial plaque and scar tissue. Another component of arterial plaque is calcium and this must be addressed along with the other recommendations. Vitamin K2 and an herb called chanca piedra are two of the best ways to reduce arterial calcium.
I have started nattokinase also. You might want to study the dosages of Nattokinase but be careful because too much can also have serious side effects, because it's a blood thinner afaik. In the one study I saw, they only received results with 10 000 FU, and doses like 2000 FU didn't do anything, so if you haven't read it yet, Google it.
You’re correct. He missed the mark with the outmoded faulty cholesterol hypothesis.
Sir good evening from Italy. Can you recomand NATTOKINASE for me? Thanks
@@LorenziniLuigi-gl1mg If you have blockage of your arteries then nattokinase is one of the things I would recommend. As I mentioned, I would also address the calcium in your arteries. As a final note, long term water fasting has been shown to reduce arterial blockage. These along with a proper diet and exercise is what I would recommend.
@@yogimaster1 I thank you very much. I Will take NATTOKINASE AND VIT. K2. Many greeting from Rome to America.
Great video! I'd be interested to know what role triglycerides play in all this. Is that part of the inflammation component? Thanks!
Always enjoy your in-depth analysis of these subjects.
A possible subject for your further studies might be white blood cell counts as they relate to CHD. You might find Some interesting results.
Thanks for all you’re doing.
I have an in depth video on inflammation and CHD, if you're interested.
A discussion with Dr Malcom Kendrick would be excellent
The latter 2 of the 4 factors are no doubt important. The effect of LDL is questionable, but it is a much bigger discussion. Regarding blood pressure, starting at 5:48, I'd propose the inverse relationship: clearing of plaque lowers blood pressure as the artery becomes less rigid and more elastic. With less plaque, we expect the pulse pressure, {sys - dia}, to drop. Lower blood pressure is the effect or consequence of clearing plaque.
Separately, would you dive into the mud of supplements for plaque clearing? Kyolic, lumbrokinase, nattokinase, pomegranate juice?
This is a great video. I will add, no one ever talks about fluid dynamics. Most sites of arterial occlusion are at bifurcations: femoral, carotid, eg, (I worked in a hospital department where we did those exams) and are no doubt exacerbated by high blood pressure. Not sure what one would do with that info other than to take steps to lower BP.
I really appreciate both the research, and how you communicate the findings to us lay folk! I'll keep on doing the Triathlons then by the sounds of it🏊♂🚴♀🏃♂
Love the gasp sound effect :)
I have also read that high amount of endurance exercise can actually cause atherosclerosis? People like marathon runners and other endurance athletes might actually get plaque from the increased inflammation caused by their high training load afaik. And you could have mentioned things like nattokinase+K2 that at least in one study was able to reduce plaque in higher dosage. I'm also personally interested in the idea of substances like citrulline and AAKG possibly being beneficial in this regard to them increasing nitric oxide leading to better circulation. Might be an idea for another video: evidence of natural suplements/foods that can lower LDL, increase circulation/heart health and perhaps even reverse plaque. Some sustabces that come to my mind are: AMLA, Citrulline, AAKG, EDTA, Nattokinase, K2, Serrapeptase, B3, Pomegranate, Garlic.
Add lumbrokinase - 30 times stronger than nattokinase
@@burtondavis4218 tnx for the tip, the first time I heard about that. Surprising that there are so many potentially beneficial compounds without prescription that I never even heard of yet.
Todos tus videos son fabulosos, no me los pierdo, son la mejor manera de aprender y aprovechar el tiempo educandonos.
Saludos desde México y gracias por el enorme esfuerzo que pones en cada video. Suscrito.
Thanks for this video I have high LDL and have been worried about this but not much resources online point to solutions.
watch Dr Berry, Dr Bikman , Dr ovadia, Nick Norwitz from Harvard, Paul Mason , Dr David Diamond (professor and neuroscientist) Dr Chafee and DR Shawn Baker and Dr Nadir. These are just a few to start with who will tell you everything you need to know. They are not your typical mainstream that are involved with big pharma.
Stress leads to high BP, and jobs causes most stress. So if you want to be healthy do not work
🤔Unfortunately, lack of money also increases stress.
Find work you love and you would never work again at a shit job. I not was so lucky.
Goal should be to work enough to invest in income producing assets so that your money works for you.
make money but also stay frugal and don't spend on stupid stuff. dont buy the latest iphone, the best clothes, best car yada yada yada
@@pkmkb007I’m 44 been investing all my life in property and global ETF. I could retire tomorrow. I’m always stressed 😣
doesn´t increased plack cause bood pressure to rise? so the correlations probably indicates the effect of plack on blood pressure and no vice-versa as you suggest
This is brilliant, thank you 💪
Love your in-depth content. Thanks!
Ok. Author of this interesting video hasn't mentioned single the most important factor shaping first 3 described contributors. - insulin resistance. I.R. is central factor affecting all mentioned mechanisms. HDL level is highly controlled by insulin level - the higher insulin concentration is - the lower HDL is. The higher insulin is - the higher concentration of fasting trigylcerides (which are far more atherogenic than LDL) . High TG also makes HDL to not work... Insulin per se is central proinflamatory hormone. The higher insulin concentration - the higher mentioned cytokines and chemokines concentration is observed. Insuin is primary driver of hypertension - responsible for about 90% cases of this disfunction. When you lower your insulin in majority cases hypertension gets withdrawn. Vitamin D3 and K2 are important factors in atherosclerosis prevention. The rerason for this is that when body has low status of these vitamins macrophages can't digest this oxidized molecules (VDR receptor is not activated) and K2 is required for effective HDL in reverse transport of cholesterol. And third issue - macrophages in order to digest need activate autophagy (this is so called sine qua non requirement), but they can't do it when insulin is high (insulin hampers or even stops completely it). So when insulin is high, macrophages tend to form foam cells (instead leaving endothelium) and eventually die. Summming up. LDL is the least important factor involved here (with exception when it is very high > 180 mg% or simultanously TGs are high twoo). LDL blood concentration is also the least controllable by diet. In contrast HDL can be easily raised up 100%, TG can be easily lowered from 300-700 mg% to 130 mg% - none of these two is achievable by drugs to this extent...
What’s the best way to increase HDL and lower triglycerides, other than a healthy diet? I suffer from both. I am very insulin resistant and my lipids doubled on low carb diet. It helped a1/c levels from pre diabetic to low 5’s. Weight stalled in 220’s-230’s. I now stopped saturated fats, upped more protein and eat more seafood and started weight lifting along with walking and biking. Weight loss is resuming again, so I hope I’m heading in the right direction.
What has really helped me is the things you are doing. I started taking creatinine and taurine. These are really helping build my muscle with the resistance exercise. The LDL shooting up on a low carb diet is a natural expression of switching to a more fat based metabolism. Don’t worry your LDL will stabilize. I take a low dose of Crestor and also niacin . The niacin will reduce LDL , raise HDL and help lower triglycerides. I do time restricted eating 8 he eating window and walk before eating breakfast. Keep doing what you are doing and your insulin resistance will go down. Especially if you lose more weight. Fatty liver and pancreas are implicated in metabolic disorder and insulin resistance which are closely related to diabetes and CVD risk . Both are the highest risk factors. Watch Dr Roy Taylor’s video on his fat tolerance and diabetes video. His diabetes research involved his patients losing weight to reverse their type 2 diabetes. No doctors are checking blood insulin levels of CVD patients except for a few. As stated above high insulin seems to be the primary cause of CVD and lowering it is helpful. I am sure time will show that Poor metabolic health characterized by high LDL. Low HDL and high triglycerides are a symptom of insulin resistance. Statins although they reduce LDL also are anti inflammatory which may account for the primary benefit not lowering LDL. . My theory is that plaques are your body trying to heal itself from contractions inflammation caused by all of the associated risk factors, the continuous inflammation leading to An uncontrolled inflammatory response causing Reprures of immune response leading to stroke and heart attacks. A decrease in NO seems to be related to as expressed by this NO expert. ua-cam.com/video/KKti_a2ubho/v-deo.htmlsi=k3xraCASuJy851J_
@@prestomattwine Too little information to give decisive answer. But I can give some general tips. 1. it is observed that adding just as little as 30 grams of complex carbohydrates to a meal can restore (lower) LDL levels (you didn't mention what kind of lipids you have above recomennded levels). So maybe ketogenic diet is not the best option for youi and around 70-100 grams of carbs per day would be better option. 2. HDL is low when Triglycerides are high and these are high when insulin is high and/or you eat much of (poly)ybsatyrated fats omega-6 or oxidized - trans fats present in seed oils. Choose olive oil as an addition (up to 50-70g per day). 3. eggs and fish help raise HDL provided that TGs are correct.... 4. hypothyroidism may keep high LDL, high TG and low HDL. Level this if you have issue (don't forget about deficiencies of selenium even if TSH is correct). 5. Give a chance for 24-36h (water/electrolyte) fasting once or twice a month. You're generally on the right track. But it takes time - sometimes even 1-2 years. You need fasting insulin < 8 or even
@@TCBytom Thanks for the reply and good advice.
@@prestomattwine
Do you eat dairy? My weightloss stalled at 210 despite low carb, IF, circuit weight training and low sugar consumption. Once I stopped eating even organic yogurt I lost more weight. 205 at 6'2", but 10 yrs ago, IF and a daily 30 minute swim got me down from 215-190 in 3 mos. Now 55 yrs.
CAPSAICIN CAYENNE PEPPER
It will be interesting if you look up into the recent Cell paper on Cholesin linking gut bacteria and cholesterol synthesis.
Great info thanks!
What about Berberine, TMAO, Mediterranean and Vegan diets? Don't they reduce plaque?
My cardiologist told me he sees thin people with perfect bp, blood sugar, who exercise. He likes to lower ldl below 50. He also say air quality and plastic increases heart disease. He never checks for fractionated cholesterol. Stress tests are not recommended unless a person is having symptoms.
Super useful and really well presented. Subscribed
Thanks!
Many people seem to do all four of these but see a doubling of their CAC score. Some say the raise is due to soft plaque becoming more stabilized. I would like to see data if this event is hurtful or beneficial. Great Info!
Do a stress test (mentioned at 10:05 in this video). They are not necessarily reliable. In Sept 2015 I did a stress test with my cardiologist and after finishing it he obviously liked what he saw and told me any insurance company would write me a policy for $1,000,000. And yet, I had just done a CAC scan and my score was 737, which is high (I was 66 years old at the time). Bottom line... triple bypass surgery 8 months later (May 2016).
@@DK-pr9ny No medications. Lipid values in Sept 2015 (in mg/dl): Total Chol 212, Trigs 64, HDL 47, Trig/HDL ratio 1.36, LDL-C 152. Also HbA1c 5.4%.
@@Malcolm-Achtman I'm surprised they didn't want to put you on statins with an LDL-C that high. Otherwise, the numbers don't seem horrible. It would have been interesting to see a particle profile on you for that time period, to see exactly what size/types of LDL you primarily had. I think you're a good example of why there's a growing consensus that the standard lipid profile tests don't really tell the whole story - or even tell lies that give a false sense that everything is A-OK.
@@RickinICT The closest advanced lipoprotein test I had (time-wise) relative to my bypass surgery in May 2016 was a SpectraCell advanced Lipo Panel done in July 2016. First, the regular lipid results were (in mg/dL): Total Chol 199, Trigs 59, HDL 47, Trig/HDL ratio 1.25, LDL-C 143. Also HbA1c 5.1%. Now for the particle results (in nmol/L). Total LDL particles 950 (ref. range is 900 or less), Remnant Lipoprotein 62 (ref. range is 150 or less), Small Dense "LDL III" was 351 (ref. range is 300 or less), and Small Dense "LDL IV" was 90 (ref. range is 100 or less). So basically I was within or sometimes a bit above the reference range with respect to particles. As far as statins go, my doctors wanted me on them since the "dawn of time" but I always refused them. My doctors still want me on statins today, especially now that my LDL-C is in the 250 - 270 mg/dL range. But I won't take statins and I get the final say.
My husband was having some chest pain and his doctor ordered a stress test. He was told that his heart was fine after the stress test and sent home. His pain got worse and turns out he was having a heart attack during his stress test .... still don't understand how that wasn't picked up
@@soniaforkas1415Amazingly disturbing.
Any decent evidence for Vitamin K2 being of benefit for artery health / plaque reduction?
In my case it helped. I had a calcified mitral valve indicated in an echo cardiogram. Started taking K2 and high k2 foods such as grass fed butter and 2 years later my valve was no longer calcified.
Excellent video many many thanks. At 10:54 you mention a 'full analysis' video and intended to put a link in the video. Do you have a link to this full analysis video that you can post? Or is this for subscribers only? Not sure.
Feel better! Nice vid
Ivor Cummings already solved this directly,and its really a great series to watch. researchers are lost still in focusing on cholesterol.. . . its diet and its sugar not fat.
his slide at 2:14 shows oxidized LDL, where it cant find its way in Lipoprotein mechanism, LDL is life. also never mentions about Tryglicerides :-D .which is the problem. and carbs. LDL is mostly produced by liver. ..also.problem is oxidzing it. (which Glucose is the reason)
I am a believer in Nattokinase. I started taking it a few years back.
Content releasing soon on that one
Blood pressure perfect 115/68 no meds. Personal trainer HIIT instructor. But with LPa-4 CVE’s no damage, but 9 blockages 🤷🏻♀️. It’s a nightmare for the many reasons I’m sure you know. Hopefully they will continue to do trials for reducing LPa, until then Rapatha is my only option. Thank you for sharing 🙏
Have you looked into SuperSlow training? It's generally considered strength training, but the long, slow sets, (often 2minutes /6x 10-10 reps),with 'lighter' weights, & minimal breaks between exercises, combines strength & cardio benefits.
The BIG question: Is LDL causal?
Increased LDL could be the body's response to inflammation.
We know LDL is involved in cell building/repairing processes.
Question 2, what's causing the inflammation in the arteries in the first place?
Have many videos on the topic
Even if LDL isn't casual for atherosclerosis, it absolutely accelerates the problem. While it could be that inflammation is the root cause, higher levels of LDL still causes higher level of plaque deposition- more LDL is present to respond
Oxidised (damaged) LDL is causal, ordinary LDL is not. Oxidised LDL is directly pro-inflammatory to endothelial cells and in addition it is taken up by macrophages in an uncontrolled way, which is why they then swell up to become foam cells.
@@mattermat1925 Ten years ago this was science.
@@mesterferenc2688 What is it now? A conspiracy theory?
I envy your ability to chew large chunks of data from different RCTs and give it to us in an understandable 10 min video. Special mention on those sarcasms that catches me off guard when I'm comprehending you at 2x.
Great vid. Well explained
I’ve read that some studies indicate that aged garlic is also beneficial for reducing plaque. I currently take 1200 mg. daily.
Is this calcified hard plaque, soft plaque, all plaque, or unknown/undetermied type?
What does it matter? Hard plaques cause heart attacks and soft plaques cause strokes
@@larryc1616I think the general discourse is that hard plaque is more difficult to remove so Peter was asking if the video applied to hard plaque or only to soft plaque
Another optional step might be nattokinase supplementation. There are a couple studies showing plaque reduction after nattokinase intervention. However, it must be at a high enough dose. The two studies I have seen that showed reduced plaque used doses of 6000FU/day and 10,800FU/day.
And it may have synergistic effects in combination with red yeast rice.
Just some other things to consider. More research and data is needed, of course.
I periodically take a full spectrum of proteolytic enzymes including 2000 FU of nattokinase per day. Proteolytic enzymes are fibrinolytic, or they break down fibrins, which are proteins that are components of plaque and scar tissue. Another component of arterial plaque is calcium and this must be addressed along with the other recommendations. Vitamin K2 and an herb called chanca piedra are two of the best ways to reduce arterial calcium.
Red yeast rice contains a chemical that drug companies turned into a prescription medicine. The medicine lowers cholesterol so it makes sense that it would help with plaque
@@yogimaster1 10000 FU may be needed.
Yes it's a statin
@@rayzerot
My non-study supported hypothesis on a contributing factor as to why exercise decreases blood pressure is that raising BP during exercise places a stretching force on the arteries which "exercises" the arteries and keeps them flexible. So as your pressure fluctuates during the day the arteries automatically accommodate the added pressure by stretching a bit. Same blood volume plus more pipe = lower pressure. Like two rubber bands made the same day if one is used from time to time and the other just sits in a draw for 10 years when both are then given a good stretch of equal amounts the exercised one stretches but the dried up stiff one just snaps.
I went carnivore and then transitioned to keto a while back. I lost weight, my blood pressure dropped, my HDL shot up to near 100, my inflammation markers went to about as low as can be measured, and due to better joint health I have been able to do more HIIT.
HOWEVER, as a lean mass hyperresponder, my LDL went up considerably. It seems counterintuitive to me that this dietary change would bring so many benefits that correlate with better cardiovascular health and potential for reversing athersclerosis, but then would cancel all that out with higher LDL.
Is it possible that it's not the level of LDL persay but the type of LDL (large or small particle, more or less oxidized etc.) that is crucial?
I think the weight loss did more for you than the carnivore. Limiting saturated fat (which is high in animal foods) helps to clear the arteries.
@@ianbryant...huh?
Claiming LDL and cholesterol causation is fake science ,including saturated fat.
As far as l know and all the studies l read till now…the cholesterol hypothesis is just that…in the absence of vascular inflammation there can’t be any plaque progression…because there is no injury or any LDL that can be oxidised. Thats just my 2 cents.
@@maxwatermeyer4406And just where are these people that are avoiding the inflammation and avoiding the atherosclerosis? The average person has their first fatty streaks in their arteries by age 13. Anyone in an industrialized nation gets inflammation from just pollution in the air, nevermind people's relentless stress and other environmental contributors. Unless you're eating an extremely anti-inflammatory diet, lowering LDL levels is the most effective way to avoid atherosclerotic buildup.
I have lost weight, blood pressure is down, exercise regularly BUT LDL increased very high (Lean mass hyper responder). Any comments?
Doubt it . Are you on a carnivore diet?
Ketovore@@MR-fn7rw
Physionic I would like to ask are you refering to soft plaque or stabilised plaque to be exact. TQ
great video...its also possible to reduce cvd risks by regular whole blood donations which lower viscosity and blood pressure, decrease the toxic burden of excess unbound iron, reduce ldl oxidation and production, and help the liver function better...bioavail copper and its transports/enzymes and cofactors like magnesium and retinal help recirculate the body's iron
Others:
Magensium supplementation - not much - don't combine with blood thinners
Vitamin K2
Nattokinase - blood thinner (don't combine with other blood thinners)
bioflavonoids - often blood thinners (don't combine with other blood thinners)
Inositol
ACV
Omegas - flax
oatmeal - keep calcium low(ish) during therapy
Nattokinase and Serrapeptase need some serious studies done, if they can actually break down arterial plaque like some claims that are out there it is nothing short of a miracle. Usual old story, I know who guy who reversed supposed irreversible heart disease with these enzymes, and of the occasional doc recommending them for the clotting which seems to be 'going around' lately.
@@petecabrina I'm taking nattokinase too now, in one study they found it effective at a higher dose 10 000 FU, but don't just start taking it because it can have dangerous side-effects at those higher doses. Substances I'm interested are: AMLA (lowers LDL as much as statin in one study), Citrulline, AAKG, EDTA (one guy has video on youtube how he supposedly used it to lower his plaque, but the issue is how to get it to bloodstream), Nattokinase, K2, Serrapeptase, B3, Pomegranate, Garlic, Omega 3.
@@petecabrina - There ARE EXISTING good studies actually. Nattokinase alone has proven pretty decent. With a full therapy with other things like omegas, magnesium, inositol, healthy diet, and exercise, you could likely clear your arteries completely. They just have a timeline for everyone as part of their societal agendas. Especially for the POOR. You see how long the Lords of the stock market are living... I saw a friend die of some buffoonery (crap at the hospital with infections and blood pressure dropping - crap like that) as he was IMPROVING from his pancreatic cancer.
Arterial plaque is composed of numerous things, but much is calcium/cholesterol deposits stuck to it. If you get calcium on the low side, and cholesterol on the low side, and use nattokinase to break up fibrin, things start coming back into solution - like an equilibrium. Just like if you get metals out of your gut, they also come out of your brain - eventually. Chlorella is my recommendation there if you aren't allergic (a small percentage are)
K1 is the blood clotter, not K2. K+ is potassium. Many people are confused by this.
@@darrenvail8726 "The difference in structure between K1 and K2 is seen in different absorption rates, tissue distribution, and bioavailability. Although differing in structure, both act as cofactor for the enzyme gamma-glutamylcarboxylase, encompassing both hepatic and extrahepatic activity. Only carboxylated proteins are active and promote a health profile like hemostasis. Furthermore, vitamin K2 in the form of MK-7 has been shown to be a bioactive compound in regulating osteoporosis, atherosclerosis, cancer and inflammatory diseases without risk of negative side effects or overdosing"
Wim Hof Breathing helps.
Should have received his 🥇 Nobel prize, a genius.
I'm at a very healthy BMI, have great blood pressure, statins have reduced my LDL to almost low levels, and I've also been eating a healthy, primarily plant based diet. I do however have familial hypercholesterolemia which seems so far to be an independent factor.
Is there perhaps hope for me reducing my arterial plaque?
can you PLEASE do a follow up video on LOWERING LPA ????
your other video didnt give solutions
Sauna at 174 degrees, 20 min, 4 x a week. Studies out of Finland (heard from Dr. Rhonda Patrick). Join the ymca to use one. You don't have to be rich.
Link?
Great study on sauna!
It seems there's a user bias: It's usually wealthy who use a sauna, and they have healthy lifestyles.
I go to the ymca under a family membership to use a sauna. You don't have to be rich.
Kind of with you, except for the ldl levels. Oxidized LDL is bad, but if it's not oxidized, it's fine and even very healthy.
Is there a threshold that LDL would need to be reduced to for plaque reduction?
I'm wondering what effect the increase of autophagy, during OMAD and occasional longer fasts, has on plaque if it comprises of cholesterol, macrophages and protein fragments?
Berberine
Niacin
K2
NATTOKINASE
Why Berberine?
There is evidence that it decreases LDL and triglycerides and increases HDL. There is also evidence that it decreases inflammation and helps in blood sugar regulation.
Niacin plus Berberine..?
I have been tsking Berberine for about 2 months now. It amazingly cleared up my blocked colon caused by shingles. And gives me great energy so I can work like 40 yr old at my age of 82..😅
Yes. D3+k2 + nattokinase + berberine or metformin + B3 + intense exercise (get blood pressure max for short time)
My friend, an anecdotical example that indicates just the opposite: 5 years ago I did a CT-scan resulting in a CAC-score of 148. I already lived very healthy more or less during my whole life. After the relative high CAC-score of 148, I started to take a statin (my LDL-level reduced with 30%) and started to live even healthier: now more or less fully cutting out ultra-processed food (eating a Mediterranean diet), and increasing the amount of sports (now 5 days a week, 2 to 2,5 hour per day in the gym, consisting of 1,5 hour resistance training and 0,5 to 1 hour cardio (either zone 2 or zone 5 training). My blood pressure is normal 120/80. My weight is 80 kg with about 12% fat percentage. After 5 years living with this regime I did again a CT-scan resulting in a CAC-score of 572, i.e. a more then 300% increase over 5 years. So it looks like I am the exception all those scientific studies performed.......
Could be a vit k deficiency
Do you have a family history of cardiovascular disease?
Curious, have you tried K2 MK-7?
Cardiologist Dr. William Davis often mentions people (like you) who discover their CAC is rising 25 - 30% per year despite taking statins. Apparently, some studies have shown that statins increase coronary calcification. But putting that aside, Dr. Davis looks at other more relevant factors. He has seen good results when people avoid all wheat and grains, keep their carb consumption under 15 grams per meal, no snacking between meals, limiting postprandial (after-meal) glucose increases to as little as possible (he calls this the "no-change" rule), optimizing their vitamin D3 (25-hydroxy) to 60 - 70 ng/mL, optimizing their thyroid health and testing it properly (6 tests required for that), using fish oil supplementation - although that's lower on his priority list - but he encourages fish oil especially if you have high Lp(a), and finally, something he is putting much more focus on these days, managing gut health using his numerous do-it-yourself strategies.
CAC only measures calcified plaque, which is stable. It tells you nothing about soft plaque.
A more comprehensive angiogram might give you more info.
(I'm not a doctor)
Excellent video !
I am a lifestyle medicine educator based in china. I love your graphics! Did you create them yourself and if so, how did you do that?
No mention of hyperinsulinemia caused by high carbohydrate intake? This should be the #1 suggestion.
Especially since reversing the high insulin and subsequent inflammation will aid in, if not completely reverse both obesity and HBP. The LDL comment I question, as much of the research is finding high LDL to be protective, especially as one ages. I think he’s done a video on not doing a lower carb/keto/carnivore diet.
Yes. Puzzling and interesting in its abscence