How do ACE & ARB's Work? (+ Pharmacology)
Вставка
- Опубліковано 28 чер 2024
- Antihypertensives are a class of drugs that are used to treat hypertension. Antihypertensive therapy seeks to prevent the complications of high blood pressure such as heart attack and stroke.
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Time Stamps:
- Intro 00:00
- Breakdown 00:40
- RAAS System Overview 01:00
- Mechanism of Action 03:23
- Common Drugs 05:25
- When to Use 07:56
- Side effects 09:00
- Contraindications 11:12
- Quick Summary 11:59
- Short Quiz 12:52
Answers:
1.)C 2.)A 3.)B 4.)C
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This pharmacology lecture covers topics such as pathophysiology of hypertension, regulation of blood pressure, cardiac output, systemic vascular resistance, baroreceptors, alpha & beta receptors, vasoconstriction, vasodilation, renin-angiotensin-aldosterone system, bradykinin, nitric oxide. Mechanism of action of antihypertensive drugs and their side effects; adrenergic antagonists; alpha & beta blockers, centrally acting adrenergic agents, dihydropyridine & nondihydropyridine calcium channel blockers, loop, thiazide, potassium-sparing diuretics, renin inhibitors, angiotensin converting enzyme (ACE) inhibitors, angiotensin II receptor type 1 blockers (ARBs), endothelin receptor antagonist, dopamine-1 receptor agonist, peripheral vasodilators. Drugs mentioned include; Doxazosin, Prazosin, Clonidine, Methyldopa, Amlodipine, Felodipine, Nicardipine, Nifedipine, Diltiazem, Verapamil, Furosemide, Hydrochlorothiazide, Triamterene, Spironolactone, Aliskiren, Benazepril, Captopril, Enalapril, Lisinopril, Quinapril, Ramipril, Candesartan, Irbesartan, Losartan, Olmesartan, Valsartan, Bosentan, Fenoldopam, Sodium Nitroprusside, Nitroglycerin, Hydralazine, and Minoxidil.
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Hope this video helps you out!!
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I want ask you: do this drug interact with *serine protease inhibitor* ?
(like camostat)
thanks for making this video..
very helpfull
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Outstanding presentation and teaching ... succinct and clear... congratulations
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@@DrugChug you're welcome! 🤗
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I’m currently studying pharmacology and this makes so much more sense!
I was preparing to fail but may have found a lifeline
You are a really excellent teacher....I love the methodical way these are presented, organized and it helps to understand "why" which helps to memorize or actually learn the drug categories. You add a brief patho to start helps understand the MOA and the "which patients should avoid " which helps understand and side effects.
Thank you so much for your support! @Marlana I'm glad this teaching style is working!
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Thank you for the support! More videos are being worked on as we speak! 😁
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Wow, thank you! I appreciate the support
Really awesome video! Helped me a lot, wouldn't be able to pass pharmacy school without this! Thanks!!!
It has taken me months to understand blood pressure medications .Finally they all make sense .Thank you
This is the best explanation of these 2 drug classes. Thank you!!
Thank You! Appreciate the support!😁
the best explanation, this is just awesome. You made it so easy to understand something that looked so hard for so long
Thank you so much for watching! Glad it helped!😁
WOW. AMAZING. so many different videos..but your video was the only one I felt was made it extremely simple to understand. Thank you.
Absolutely love this! Thank you so much for your hard work! Would absolutely love if you could do more on vasopressors or inotropes! Thanks again my friend :D
You're welcome @Christina ! More videos are planned and will be released soon! Vasopressors and ionotropes are on the list!
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Thank you so much for the support!😁
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Formidable!!! Thanks a million!!!
Great explanation thank you so much sir for your time and efforts
Excellent teacher, what a clear lecture.
This is the best video in all the videos that explained ACE& ARB❤❤❤
Thank you! Great content!
wow I am so happy I found this channel!!! Such precise information and beautiful explanation!! Thank you so much sir!
I wanted to hear a lot more explanations from you, but your channel seems to have only few videos..
Please make more videos!!!!!!! I would love to learn from you.🙏🏻🙏🏻
Thank you so much for your support! More videos to come!
I am going back to get my ARNP at 52!!! and at Duke!!! and you are my new BFF!!! Helping this old brain break it down!!! THANK YOU!!!!!
No such thing as an "old brain" ! You got this! And I'm glad I can help!
@@DrugChug Everybody is getting a drug chug t shirt for xmas this year :-) I love the antibiotics one
I appreciate the support 🙂
I have pharmacology exam on Tuesday and this helped me a lot. I love it 🥰 Thank you so much Sir!!
Thanks so much for these videos! I'm a second year medical student and these have been really helpful
You're very welcome! Glad to help! Now go ACE those exams!
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Thank you so much, and now i'm getting ready to write my thesis!
Woohoo! That's awesome to hear! Good Luck😁
Amazing explanation! Thank you so much!
Thank you for watching! :)
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Amazing video so simple and understandable thanks to you ♥️
Thank you for the support!😁
Perfectly explained. Thanks
Thank you Razin! Appreciate the support!😁
Learning Pharm for Dental Hygiene - thank goodness I found this!
You are the best teacher of the pharmacology
fantastic explanation sir,requesting to continue your fantastic explanation.
Very clear explained. Thanks
Thank you for watching!
Very helpful knowledge with someone just diagnosed with high blood pressure
Thank you so much for your hard work
Youre very welcome. Thank you for watching!😁
Amazing videos! Helping me study in nursing school!
Thank you so much! Feel free to share with your class! 😁
A very well explained video. Thanks
Thank you so much for watching! 😃
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No problem!😁
This is so awesome. Thank you so much for your time. Do you have a video on ABGs? Would you please consider making one ? As a nursing student your videos are saving me right now. Thank you.
Thank you 27capricia, keep studying hard! There are more videos planned such as ABGs. But due to the time it takes to make these videos, it may take some time to make!
Wonderful lecture,
Thank you!
excellent lecture, thank you Sir
very interested video thank you please we need more interested video
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love all these, find it so helpful can you make one about NSAID's
Ofcourse Kelly! More videos coming out in the future, and NSAIDs are definitely on my list!
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Thank You for the support! Unfortunately, loving to teach comes within, and these professors who dont care will never teach effectivly.
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Thank you so much for watching!😁 yes more videos are planned!
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Thank you for the support! 🙏
I find these videos so helpful! Could you do one on potassium channel blockers if you get the chance please, I’m struggling with the antiarrhythmics
Thank you Sir
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11:58pm thank you for explaining
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Thank you! and Yes! Those videos are already in the pipeline!
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Thank you for the amazing video. I managed to have an case of angioedema from 20mg of Telmisartan. It was mild and managed with histamines but does this mean all other ARBs are out for treating high BP ? Im an endurance athlete so trying to avoid cardio effective medications and was considering Losartan.
Excellent video. I would have liked to hear more about side effects of ARBs. Ive been on Telmisartan for one month and am having a few issues. But what is really more than a nuisance, is dry eyes, which I assume is d/t this drugs effects. I wear RGP contact lenses so this is very annoying.
more videos please
Thanks for sharing this amazing video, it was really useful. As a nurse, I benefited from this. But there is a question: you say that our kidney has Angiotrnsin one receptor, but how can Angiotensin two bind to it?
The receptor is actually called angiotensin 11 type 1 receptor
Please make video about drug interaction,how to classify it pharmacodinamic or pharmacokinetic
Great idea! More videos are planned and I will add this to the list!
@@DrugChug i'm so looking forward for it..thank you
Thank you for the great video! Ive learn a lot from this video!
Question! So if ACE inhibitor/ARB reduce the sodium and water retention, does it mean these medications can also be diuretic?
If so, then why would they make hyperkalemia if they can be diuretic?
Thank you!
Thank you Lin for the support!
ACE & ARBs do reduce some sodium and water retention, however it isnt a main mechanism. When compared to Thiazide and Loop diuretics-ACE's & ARB's are negligible so we cant consider them as a diuretic.
When we talk about diuretics, there are 3 types and they focus on 1) different parts of the kidney and 2) Different electrolytes. One class of these diuretics are called "Potassium sparring diuretics", meaning they let go of all other electrolytes (Na, Ca, Cl) and hold onto potassium (K+). The reason I bring this up is that just because something is a diuretic or has diuretic-like properties, it doesn't automatically indicate hypokalemia. These ACE and ARB medication just promote the holding of potassium specifically. Thats why we see hyperkalemia!
Hope that clears somethings up for you!
Tank you
You're very welcome!😁
Bravo
Thank You!😁
The primary BP lowering effect of ACE/ARB is achieved by interfering with vasoconstriction. The loss of sodium and water is secondary.
Was wondering why this wasn't mentioned in the video--thanks for building on!
Excellent video but I don’t understand why you only talk about the effects of angiotensin on the kidney without mentioning the effects on the arteries, heart and nervous system
Make video on antivomiting drug
Sir plz make more videos on drugs.
Wich medication naturel you can take for lawyer blood pressure
Angiotensin 2 binds to receptor of angiotensin 1? 2.32
I do not see Perindopril here on your list of prils. (or Perindopril Erbumine?) Mine is an 8mg combo with Indapamide 2.5mg.
Can you make a video on ACE Inhibitors and how to avoid lifestyle habits that may work against the medication straining the heart or perhaps what might even amplify it dangerously? Like diets(certain foods), types of exercises, and how much, certain supplements, other medications like anti-depressants, particularly SSRI medication, benzodiazepines, metformin, Salbutamol, and even how certain drugs and /or alcohol may affect the body while taking this medication?
I read somewhere that ACE inhibitors are very powerful, powerful enough to completely stop even certain methamphetamine processes in the body. And is it true that if you have been taking a Pril for years and then stopping it, the effects of the medication can last nearly a month or longer? Anyways, thanks!
Ans1-diovan
Ans2- ACE
Ans3-losartan
What about headache as a side effect?
I wish you explained the hyperkalemia side effect.
This side effect requires more explanation in the hormonal process of the body. But in general, ACE's and ARB's effect the hormone level of aldosterone with make the kidneys hold on to potassium more, causing hyperkalemia
Hope that clears things up!
Does long term use of ace inhibitors cause ckd?
How bradykinin naturally cause increase in BP
Why can’t I like 100 times
Thank you! I wish you could too haha!
Excellent Video . I have a condition called Atrial Fibrillation and I experience heart palpitations only when I have high Blood pressure . I am 82 years old. I take Bisoprolol 2.5mg. I was prescribed 4 different types of blood pressure drugs and I have very serious side effects.
I tried Amlodipine, Candisartan, Indapamide
Felodipine and Ramipril.
I have been on Bisoprolol for over 3 years but for the last 6 months my blood pressure reading is over 150/75 The only drug that I don’t have any side effects is Ramipril. But my Doctor says it is affecting my kidneys.
I don’t have diabetes. Could you suggest which drug I should try ACE Inhibitors that are safe for kidneys.
All the above drugs cause increase irregular heart rate and arrhythmia, dizziness.
Only Ramipril works on me but Doctor is not in favour.I should be very grateful for your reply.Thanks.
Healthcare professionals can't diagnose or prescribe medications on UA-cam, but given your health history, you might benefit from finding another doctor in your area and getting a second opinion. Best wishes!
❤
Would there be a reason for a doctor to prescribe an ACE inhibitor with an ARB?
Always discuss with your doctor first when making a plan to treat.
But typically No. There shouldn't be an ACE plus an ARB because it can dangerously lower blood pressure.
Why don't you post new videos?
Bro you are the shit
There is something wrong with the video. See:
ua-cam.com/video/1vZDVbqRhyM/v-deo.html
there is two "receptors" for angiotensin-2?
Or maybe only one, and the other is just a proteine?
Or this is the serine protease stuck to receptor?
where are answers to the quiz?
In the description below!
I don't found what I actually search for
A
It has taken me months to understand blood pressure medications .Finally they all make sense .Thank you