Pharmacology - HYPERTENSION & ANTIHYPERTENSIVES (MADE EASY)

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Antihypertensives are a class of drugs that are used to treat hypertension. Antihypertensive therapy seeks to prevent the complications of high blood pressure such as heart attack and stroke. This pharmacology lecture covers topics such as pathophysiology of hypertension, regulation of blood pressure, cardiac output, systemic vascular resistance, baroreceptors, alpha & beta receptors, vasoconstriction, vasodilation, renin-angiotensin-aldosterone system, bradykinin, nitric oxide. Mechanism of action of antihypertensive drugs and their side effects; adrenergic antagonists; alpha & beta blockers, centrally acting adrenergic agents, dihydropyridine & nondihydropyridine calcium channel blockers, loop, thiazide, potassium-sparing diuretics, renin inhibitors, angiotensin converting enzyme (ACE) inhibitors, angiotensin II receptor type 1 blockers (ARBs), endothelin receptor antagonist, dopamine-1 receptor agonist, peripheral vasodilators. Drugs mentioned include; Doxazosin, Prazosin, Clonidine, Methyldopa, Amlodipine, Felodipine, Nicardipine, Nifedipine, Diltiazem, Verapamil, Furosemide, Hydrochlorothiazide, Triamterene, Spironolactone, Aliskiren, Benazepril, Captopril, Enalapril, Lisinopril, Quinapril, Ramipril, Candesartan, Irbesartan, Losartan, Olmesartan, Valsartan, Bosentan, Fenoldopam, Sodium Nitroprusside, Nitroglycerin, Hydralazine, and Minoxidil.
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0:00 Pathophysiology of hypertension
2:55 Alpha-1 blockers
3:10 Beta blockers
4:01 Centrally-acting adrenergic drugs
4:49 Calcium channel blockers
7:27 Diuretics
8:57 Inhibitors of renin-angiotensin-aldosterone system
12:25 Miscellaneous antihypertensives

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Western medication forever can't effectively treat and revese hypertension.
Forget those bullshit hypertensive drugs because they're of no use.
How to reverse calcified and hardened internal elastic lamina? Western medication
can't clear up AGEs (advanced glycation endproducts) so that vessels can restore
their elasticity, flexibility and plasticity.
God's mercy nano-medication is the last-ditch treatment for hypertension.
Is it so amazing that to lower sys.pressure from 220 mm Hg to 110 mm Hg
by nano-medication.
Nano-medication is based on:
God created humans out of extract of clay from ground
During past five decades, USA, Russia, France and Germany have made
great efforts to unravel nano-medication unsuccessfully.
Nanoparticles of nano-medication are AGE-breakers and so-called
Universal Ligand (Antibody)
All glory belongs to God !

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This is a very useful refresher presentation for me, since I have been taking combinations of these medications for a number of years. Understanding their mechanisms of action often allows me to identify causation of changes in my conditions. I can then communicate more intelligently with my physicians.

[@davidlo168888]

Western medication forever can't effectively treat and revese hypertension.
Forget those bullshit hypertensive drugs because they're of no use.
How to reverse calcified and hardened internal elastic lamina? Western medication
can't clear up AGEs (advanced glycation endproducts) so that vessels can restore
their elasticity, flexibility and plasticity.
God's mercy nano-medication is the last-ditch treatment for hypertension.
Is it so amazing that to lower sys.pressure from 220 mm Hg to 110 mm Hg
by nano-medication.
Nano-medication is based on:
God created humans out of extract of clay from ground
During past five decades, USA, Russia, France and Germany have made
great efforts to unravel nano-medication unsuccessfully.
Nanoparticles of nano-medication are AGE-breakers and so-called
Universal Ligand (Antibody)
All glory belongs to God !

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[@davidlo168888]

Western medication forever can't effectively treat and revese hypertension.
Forget those bullshit hypertensive drugs because they're of no use.
How to reverse calcified and hardened internal elastic lamina? Western medication
can't clear up AGEs (advanced glycation endproducts) so that vessels can restore
their elasticity, flexibility and plasticity.
God's mercy nano-medication is the last-ditch treatment for hypertension.
Is it so amazing that to lower sys.pressure from 220 mm Hg to 110 mm Hg
by nano-medication.
Nano-medication is based on:
God created humans out of extract of clay from ground
During past five decades, USA, Russia, France and Germany have made
great efforts to unravel nano-medication unsuccessfully.
Nanoparticles of nano-medication are AGE-breakers and so-called
Universal Ligand (Antibody)
All glory belongs to God !

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Great video. I just wanna make one small correction in the begging you say that renin is stimulating the convertion of angiotensin 1 -> angiotensin 2, this job is done by ACE(lungs). What renin does is to cleave Angiotensinogen made from the liver to Angiotensin 1

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