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Nucleotide excision repair
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- Опубліковано 24 вер 2014
- Topic- nucleotide excision repair to dicscus the mechanism of DNA repair process.
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This is nucleotide excision repair in prokaryotes it is slightly different in eukaryotes. Just thought I would mention that incase people didn't realize and thought it was for in humans. Great video, all your videos are very helpful and effective.
I like the way,how he suddenly remembered & explained the difference between 'nick' & 'gap' !!Have to show your videos to those undedicated professors to their job.Huge respect & hats off!!
🥺oh!
There's some correction:
1-UVR aba. Dimer scanning the DNA for injury.
2-when finds, a portions release and b remains in the site of thiamine thiamine dimer, i. e injury.
3- UVRc come and combine with b to make 2 cuts few nucleotides away from the site of injury.
4- UVR d is a helicase Enzyme removes the cut portion.
5-DNA POL3 complete a correct strand.
6-ligase fixes it.
Thats all. 😀
I'm a microbiology master degree student and this man is my savior during finals
You're welcome
You are always so helpful, and with no need of great effects or tecnologies. Simplicity is key and you know how to teach.
I have already check your previous videos and all of them are too much helpful to me. I always get a clear concept after watching your videos. So it's my request please don't stop making videos about biology. Thanks a lot .
Sure. I will continue
Sir, you are a life saviour!day after tomorrow I have my molecular biology final and I'm depending on your videos.The way you delivery your lectures, it really helps me!thank you!!
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@@shomusbiologyofficial if you please see the doubts that i have posted , i shall be grateful to you
i think it is UvrA that makes a complex with UvrB and scans and binds to the lesion site.
though thanks for the explanation
I can not find a word to tell you thank you. You are a very talent man. Please continue your efforts to teach me and other people all around the world. Thank you again. God help you in your path. There is a very nice explanation about Nucleotide Excision Repair with nice clarification about the role of DNA Polymerase and Ligase in this process.
Thank you so much for appreciating my efforts. Glad to hear that you're getting benefit from my lectures
I really enjoy your videos. Just 2 points. This is Global Genome NER in prokaryotes, not eukaryotes. Also, UvrA first recognizes the damage then UvrB verifies the damage. Everything else is spot on!
i wish you could explain Double Strand Break Repair
thank you so much..you help me a lot in understanding molecular biology topic. i can say that you like my youtube lecturer.,
Again here sir 🙋♀️
And again Crystal clear understanding !
I have an exam tomorrow and this video lecture is really amazing.
Thank you so much for appreciating my efforts
you are genius men.
i can't believe i got this helpful video for free!!!!
Superb explanation. Thanks a million. All the way from Republic of Ireland Filipino
Thank you so much for appreciating my efforts
the lessons are very clear and easy to understand.thank you sir
You're welcome
Uvr A dimer formation is not shown which is crucial. I disagree with video data.
refer Friedburg book DNA Repair and Mutagenisis
Yes..at first UvrAB Complex should be formed.. it's A part help to recognize that faulty nucleotide...is it right??(Pathfinder publication..)
in first step, either Uvr AB complex is formed or UvrBC??? according to my info it is Uvr AB complex formation..Regardless, i like ur videos overall. .. sir ur videos really help me in my studies... i am a microbiology student 😊☺thanks
True Uvr AB form a dimer and as soon as it is loaded onto the lesion Uvr A disassociates and then UvrC dimer binds to Uvr B.
True ...
I jst love all ur video's sir. U make things easy to understand BT jst for nt getting other people confused its the AB complex formed fist which scan the DNA and binds to it then after UvrC is loaded
And you said that the UvrB and UvrC dimer scans the distortions due to leision . But once i read that UvrA and UvrB scans the DNA for leisions . Then which actually does the scan??
Thank you so much sir... it's always less no matter how much I thank you..! But you always save me..! thank you so much sir.🤗
your knowledge and your explanations both are best just keep it up and make more videos releated to genetics plz
Thank you so much sir i really want to thank you because i attempted this question in my msc exams successfully just because of you your way of giving concept to yout viewers is simply owsum 👍👍👍
You're welcome. Glad to hear that you're getting benefit from my lectures
@@shomusbiologyofficial lots of best wishes from Pakistan sir plz never give up this effort in future also we always need you
I need a teacher like u💙
you are a magnificent help to this world please please keep of this awesome work. karma
Thank you Sir... Excellent lecture Sir 🙂🙂👍👌🤗💞💕
Glad it helped
Hey 2uvrA and 2uvrB is responsible for scanning d dna lession.actually uvr A does d scanning part and it leaves thn uvrc comes and forms a complex with uvrB cz c is responsible for cleaving.
He explains everything that related to my subjects..Iam Medicine student
Lot of thank... Your diagrammatic representation easy for understand and also clear the basic things....well done good job.. keep it up
Thank you
Thanks a lot sir your videos help me for preparing for exam
You're welcome
U teach very well..
Thank you
Wrong! UvrA forms dimer with UvrB dimer by ATP at the first step🤔
Thanks Shomu ❤️🥺
You're welcome
Awesome videos you have, Shomu! Thanks a million
At the beginning it's uvrA and uvrB .
thank you sir...your almost all videos are very helpful.😊
You're welcome
U r so good...thank u for clearing the topic ..
Nd please make video on recombination repair 🙏
Is UvrB a endonuclease too?? Once i read that UvrB cuts at the 3' end of the leison and UvrC at the 5' end .
you are so helpful !! THANK YOU
+Aicha Hamdan you're welcome
Thanks for keeping it free!
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All the way from Republic of Ireland Filipino
You describe the process in very good manner but how does this effect overall body and but kind of mutation it caused. Please give some brief idea about it. Example xeroderma pigmanotosum is caused due which failed repair mechanism.
Not sure why I watched this but you are smart.
Thank you
You are a life saver 😭😭
Dhanyavad
You're welcome
Thank you!!
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Thank You , Sir
You're welcome
يكسبك دنيا واخره يا رب ❤️🌹
Thank you
You're welcome
Very useful video
You're welcome
Sir can u plz tell why UvrB is used here bcz the separation to the lesion region is made only the Uvrc ... Why we don't only used Uvrc for the process instead of the UvrB/c complex??
Thank you so much sir ❤️
You're welcome
You understood the central dogma better than the ones identified it
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Thanks a lot shomus je.. my topic cleard
+Haris Magsi glad to know that
nice and awesome video... keep it up
You are genius 👍🏻
Thank you. Glad you liked my lectures
you've been great help! thank you very much
UVrB enzymes is exonuclease or endonuclease?
Ur awesome....ur vdo's r really helping me...
Tq so much sir 🙏
You're welcome
Sir, how does an abnormal base determines it needs mismatch or an excision repair?
Brilliant Explaination😊finaallly 😌i got it🤟
You're welcome. Glad to hear that you're getting benefit from
Outstanding
Thank you
absolute help
Why DNA polymerase can not ligate the DNA nicks by phospodiester bond but can make phosphodiester bond between daughter nucleotides?
Is there any video where you described the RecBCD model in Prokaryotes ; very much needed ; pls help
You save me sirrrr❤ thankyouuu💞
You're welcome. Glad to hear that you're getting benefit from my lectures
Sir uvrB first bind to uvrA right ?
Sir please explain the double strand base repair. Its a humble request to you.please sir
Homologous recombination is already there
You are a real saviour before the exams🫂
Thanks alot sir
You're welcome. Glad you like it
Explained very well
Thanks sir ❤
You're welcome
Sir, I just want to about photoreactivation process
dont we need uvrA here because i studied somewhere that the detection process is done by uvrA
+raj kumar yes the uvr A and uvr B form a complex and slides along dna to detect a dimer or any other major disruption. on encountering a dimer in this case . uvrA dissociates and then uvrC loads
Bushra Sayeed yes... u r right 👍
Yes this is true
@@bushrasayeed8336 yeah this correct
Yes uvr a and b scan it
sir there is an UVrAB complext instead of UVrBC trimer complex as i read it from book......can u tell me whatactually that is?
Thank you sir
It was amazing
You're welcome
clear explanation .thank you
thanku sir👏
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You are amazing dude!
Great
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cyclobutane pyrimidine dimer process is same?? please tell
Sir I have confusion in this lecture.. bcz my teacher talk about UvrA protein also but you didn't
شرح ممتاز ❤❤❤
Thank you sir
You're welcome
u r the great 👏👏
Thank you!!!
really u r so much helpful sir
+sweety panchal thank you. Glad you liked my lectures
thankyou so much.
great sir
excellent
uvaA is not mentioned here, it is wrong
dude you are awesome
Very useful sir ...thanks a lot ...but there is confusion between UvrAB or UvrBC complex
Uvr A and uvr B form a tetramer may be
very helpfull ☆
why not dna polymerase 3 filles the gap...y always dna polymerase1...?
i think in this video u should talk about exinuclease isnt it ?
you are awesome!!!!! best way to learn genetics :)
+Oliver K great. Glad it helped
Oh God!You are soooo goood..🥰
Thank you
Tnx sir
You're welcome
Where is uvr A