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DNA repair mechanism - Base excision repair
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- Опубліковано 14 вер 2014
- This dna repair lecture explain the base excision repair process and its importance.
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this video was uploaded in 2014 and here in 2019- it is still very helpful... after listening to hours of lectures- this is more helpful than anything else.
thank you very much
I hope you don't stop producing more these biology videos. thanks-lifesaver
That's what most people don't understand. They mock these headphones but the relevance was ahead of time. Thank you for appreciating my efforts. Glad to hear that you are getting benefit from the videos.
@@shomusbiologyofficial I'm watching this video right now for my MSc entrance. Im so thankful to you. Those who are mocking you are unwanted flies -_-
@@shomusbiologyofficialstill useful in 2023 sir ❤❤❤
we are medical students in Sweden and we just want to say that you are amaaaaaazing and you can make all our problems easier.
best regards to the best teacher.
Everytime I don’t understand a concept or want to revise the topic, I always search for your videos. Thank you so much, Sir. Your videos are very easy to understand and interesting.
Thank you
thanku so much sir... only bcz of u i ll pass in my examination.... specially in molecular biology...
Really sir,u r explaining all the concept for basic theory which is very helpful for the students to understand the concepts of immunology,human genetics,biochemistry,biophysics...all in one sir..you are legend.
Thank you so much for appreciating my efforts. Glad to hear that you're getting benefit from my lectures
Thank u for your efforts from Iraq 🙏🏻
You're welcome. Glad to hear that you're getting benefit from my lectures
thank you 😆.. you saved my exam 😌 needed this and all ur other videos too coz I missed a lecture in clg 😑
Glad to hear that you are getting benefit from the videos
We are very proud because world nombor 1 microbiologist UA-camr live in our city kolkata 🤍🤍🤍
this guy is a legend.....physicswalla alag chalta.....ye apna biowalla sir hai.....he is so good....am a 2023 college student.....and his videos are only what i study from for all my references..... he is really good
Thank you. Unfortunately biology has never been in demand like physics as a subject all over the world
Ooooh allah
Tnx a lot to u may allah bless you
From Algeria
Hats offfffff for you
Thank you
@@shomusbiologyofficial nevermind
Aslam u alikum respected sir.... I am really feeling blessed and happy watching your lectures.. They are really helpful. May Allah almighty bless you with more and more success and may Allah give you more life. Love and respect from Pakistan...
😍😍😍😍😍
Thank you so much for appreciating my efforts. Glad to hear that you're getting benefit from my lectures
Thank you Sir...🤗💞💞🙂👍👌🤗.. You are my best favorite teacher Sir.... Thank you ..
Glad to hear that you're getting benefit from my lectures
You are truly a blessing!
Thank you
I am always watching your video it is very easy to understand your vedio .thank you for helping us to understand the critical topic in a easy way .
You're welcome. Glad to hear that you're getting benefit from my lectures
Since you were explaining about E.coli BER pathway.
you forgot to mention the role of DNA phosphodiesterase in removing the AP-Deoxyribose phosphate that was left by the DNA glycosylase.
& thats the only difference in eukaryotic and prokaryotic pathway of BER.
eukaryotes dont use DNA phosphodiesterase.
thanks sir with this great lectures, i am so glad with ur lectures bcos they are my ladders in mbbs. from shenyang medical college.........
I’m gonna sit for my exam in another one week plus and this video my god this helps me so so so so much this clears out my doubt so much😭..Thank you sir
You're welcome. The best for the exam
Hey, you are so good at explaining, the videos are actually so helpful, please don't stop posting!!!
Very nice method of teaching...Thanks
You saved me again !
Thank you so much!
Really very nice explanation sir 🙏
Thank you so much for appreciating my efforts
You made a small mistake when you spoke about DNA pol I 5'-3' polymerase activity.
The 5'-3' polymerase activity only works when you are using the 5'-3' exonuclease activity, ergo the concept of "nick translation", but when you use the 3'-5' exonuclease, one of two things must happen, either you excise in one direction, and then consecutively, move backwards in the 5'-3' direction to add the new repaired nucleotides. The nucleotides are not added while you move in the 3'-5' direction. Or you could have a distributive polymerase activity, where Pol I disassociates from the DNA and a new Pol I binds and repairs the gap via replacement with new nucleotides.
Other than that, great video
So in this case the DNA pol I uses his 3' -> 5' exonuclease activity and add new nucleotides using his 5 --> 3 ?
@@luisfreitas6435 No cut the segment of DNA by using 5'-3' exonuclease activity then siled the gap by the polymerization activity of the DNA pol-1
Thank you, sir, you make this video in 2014 in this year I was in 8 th standard and nowadays it helps me when I am in my BSc final year 😁😁😁 thank you so much!
DNAP I actually uses its 5' - 3' exonuclease activity there .
But in eukaryot it's DNA pol beta isn't it? Plz answer
You are my saviour; amazing lecture bro
You're welcome
Oh my my.... You explain really well.... Thanks for this video.... It was really helpful
great sir. seriously your are fantastic ....i really got a lot of knowledge from your all informative vedios
U are really an amazing teacher
Thank you
Watching the videos after 8 years of ur uploading.... 🥺🥺🥺
Exam Saver.... ❤️
Thank you so much for appreciating my efforts
If only my professor can explain this like you do then the class would be fun to learn.
Thank you so much for appreciating my efforts
Easy way of understanding.
Thank you
You're welcome
Love from kerala sir thanks for yur videos 😇✨️
You're welcome. Glad to hear that you're getting benefit from my lectures
Thankyou so much. Your videos are very helpful.
You're welcome
Very well explained❤❤❤❤
Thank you
it's nice but better if show it by 3D Animation. Deal on the main concept.
Pictorial explanations are needed more for MSc Biomedical students.
Thank you sir for the amazing video .....and sir i have a question that is Does proofreading repair induced mutations ?
If mistakes present, it may cause mutation
@@shomusbiologyofficial no...sir i want to know that will it repair or not ?
mistakes happen evn by d teachrs also ....iam grtful fr ds coz it help me to clear my concpt ..thank u
Sir you are doing excellent job... It's help me out to understand my Molecular biochemist lectures. You elaborate everything... I like your way of teaching. Keep it up sir 👍👍👍
+onaiza sumreen thank you. Glad you liked my lectures. Please subscribe and share
+onaiza sumreen thank you. Glad you liked my lectures. Please subscribe and share
I have already subscribed sir..
Thank you ,sir, from Sylhet Agricultural University, Bangladesh 🇧🇩
Thank you. Glad you liked my lectures
Thank you so much sir .. i love all your videos and it helps me a lot !!♥️♥️
You're welcome. Glad to hear that you're getting benefit from my lectures
It is AP endocuclease that will only cleave off the back bone of the apurinic or apyrimidine sites, how can it chew the sequence that is not the AP site. Sir plz explain.
Nicely explained... thank you sir😊
You're welcome
very well explained ... thanku for ur job...
Thank you
You're welcome
Very nice explanation..thank you sir
It's helpful ☺️
Thank you 💞
You're welcome
That a lot sir. U just saved me up
Thank you. Glad you liked my lectures
Thanks
You're welcome
It would be great if you can reshoot the videos for better clarity
U r doin awsm job
Thank you
I really like your video and explanation. Except few things that you are repeating the same things again and again to prove the same point, which i feel too lengthy.
Thank you for reporting
I love your channel, thank you for everything 😍
You're welcome. Glad to hear that you're getting benefit from my lectures
You are the best !
You're welcome
Sir plz make a video on operon model in hindi
your videos are very helpful!
Love this guy!
Nicely explained. 👍🏼
You're welcome
perfect explanation 🤩🤗
You're welcome. Glad to hear that you're getting benefit from my lectures
thank u Sir .
very good explanation
Thank u Soo much sir.... For this video
Nd please explain how can u prepair for CSIR
you did great! Learned a lot! thank you
What about flap endonuclease ?
Thank you so much
You're welcome
Great
You're welcome
Thank you sir it very good
You're welcome
Thank you 🙏
You're welcome
Is this the direct repair mechanism of DNA? Need some clarification
What do you mean by direct repair?
Photoreactivation of thymine dimer is an exmple fr tht i guess. Do you have a video on tht?? Please be kind enough to make one if not...........🙏🙏🙏🙏
What is the main difference between base excision and nucleotide excision repair??? I m confused in this.
Chcek by video on this difference
Thanks for replying.. What u told in the last of vedio just that is the difference,, I mean the difference of nucleotide, in base excision there is only one nucleotide to remove and in nucleotide, removal or 15 to 25 nucleotide?
Excellent 👍👍 thank you so much
The activity of dna poly 1 in ber for cleaving is 5' to 3' exonuclease not 3' to 5' ,other that great video 🙌🙌
And for gap filling it's 5' to 3' polymerase activity
Thank you sir..
You're welcome
life saver !! thanks
Is this for prokaryotes or eukaryotes?
If anyone knows please help.
Thank you
This is for prokaryotes
Tank you dear
You're welcome
Can anyone tell me that this is proof reading mechanism of DNA repairs or not?? Plz reply fast anyone
Coming soon
@@shomusbiologyofficial thank you so much for this😇
Thnk u very much sir.
Ur excellent
This is amazing!
+mangobananana thank you.
Thanks sir 🙂
You're welcome
Do micro biology video
Tnk u
Thankyou so much :)
Does any class I and class II AP endonuclease have any role here?
Thanks.. that helped
+Aqsa Ashraf glad to hear that
Shomu
What about deoxyribophosphodiesterase?
It cleans up the backbone by removing a strech of neighboring sugar phosphate residues so that a DNA polymerase can fill the gap with nucleotides complementary to the other strands.
Maybe this term is missing
Nice
Welcome
can u mak a video about DNA damge and repair mechanism...pls
These are videos
@@shomusbiologyofficial thank u
thanks sir
+Anita Singh you're welcome
great video but it's 5' to 3' exo
3' to 5'
Yeah , It is 5' to 3'
very easy
+Smruti Dubey thank you
nyc
well explain sir XD ty a lot
+Little Suruk glad you liked my lectures
2:35
What is Nick sir
Phosphodiester backbone breakage
👍
👍👍💚
sir language hindi me do please
Puma product placement detected
not too belittle you, but to help you grow as a educator let me give you some tips. 1. please do not say things are very very easy unless they can be explained in three or less steps. it is not easy unless you can explain it in three steps. 2. slow down you speak very fast not letting any time to let previous information be absorbed and confuse people as a result. 3. this is just how I teach , use more diagrams. Diagrams are a very good technique to show people how something works without words, people dont learn well with words most of the population find visual people we go on youtube for video diagrams
coconut7077
What a silly comments. Remember to evaluate your own shortcomings before pointing out someone else’s. This man is trying to help others - where are your educational videos by the way? Good educators don’t pick out the negatives in someone else. Your real character of insecurity and immaturity show when you need to put others down in order to feel lifted up. Great Video!!
His only flaw is his thick accent, other than that probs 100 times better educator than you will ever be
I have absolutely no problem in understanding what he teaches. Don't know what you are talking about. His videos are the most helpful.
+coconut7077 if anything is lengthy it doesnt mean it is complicated.
you are ryt yr