Antiarrhythmic Drugs

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  • Опубліковано 22 гру 2024

КОМЕНТАРІ • 311

  • @fivebagsforlife7479
    @fivebagsforlife7479 4 місяці тому +135

    I am a cardiologist and eventhough I know all these stuffs in my head I watched your videos to learn how to explain it so clearly to my students. However at this point I would just give them the link to your videos because I doubt I can explain it better than you with all these graphics😂 really well done!

    • @israa_abu3004
      @israa_abu3004 2 місяці тому +7

      This comment is so wholesome. As a student if my professors watched ninja nerd to explain to me in the best way they could, I’d feel cared for and like they actually cared to explain things to me in the best way they could.. so THANK YOU 😊

    • @سعودالسهلي-ق2ش
      @سعودالسهلي-ق2ش 14 днів тому +2

      We need professor like you . Our professor just talks about random things and teach us like pharmassist , he forgets that we are doctors we do not need to know all the dosage of drugs , half life and pharamokinetics.

  • @zeebalz7038
    @zeebalz7038 2 роки тому +123

    You made this 5 days to my Pharmacology exams. You're a G

    • @Stanleeeeeee
      @Stanleeeeeee 8 місяців тому +2

      Mine is tomorrow 😭😭

  • @VincentAubin-qz6kp
    @VincentAubin-qz6kp 8 місяців тому +13

    I've never seen a better description on the pharmacodynamics of the drugs and ways to remember them; perfect video for cramming for a test lol

  • @timothykruse8236
    @timothykruse8236 9 місяців тому +8

    I appreciate your videos. I'm a firefighter/Medic and I watch your videos periodically as a refresher. Your take on physiology and the way you teach fits my learning style perfectly.

  • @fanzone59
    @fanzone59 2 роки тому +83

    Almost 3 hours of a video= hard work= tremendously helpful and valuable information being given, thank you!

  • @joelfernandez3408
    @joelfernandez3408 2 роки тому +43

    This is hands down the best pharmacology/physiology channel on UA-cam , thank you so much for making these Videos and keep them up!

  • @doskevin4882
    @doskevin4882 5 місяців тому +8

    Quick tip to help you understand better:
    Inside of cell is more negative than outside of cell AT REST. This means they are polar. Opposite charges (the old saying polar opposites). When a cell depolarizes (de=not) the inside of the cell is becoming more positive meaning they are becoming less polar. When the cell depolarizes (re= again), it is becoming negative again back to the resting state of the cell.

  • @sofiaperan4670
    @sofiaperan4670 7 місяців тому +13

    literally the best teacher in the world.

  • @tanzeelakakroo9624
    @tanzeelakakroo9624 Рік тому +6

    Hands down the best channel to ace any concept regarding any physiological concept . Can't believe u taught Arrythmias so well that no teacher or any other video on UA-cam could have done
    "Thanks for existing Zach "❤

  • @shrutikaldhone8710
    @shrutikaldhone8710 2 роки тому +42

    Your lectures help to clear the concepts about the particular subject.... our vision becomes crystal clear. No matter how many times I read antiarrhythmics, I used to get confused and frustrated. But hey, after watching this full video, I feel a lot confident about the topic now!! I really admire the efforts you guys put in to teach the subject. And I adore your capability to learn, understand and then teach any topic that you present. I am following you since a year now, and not a single lecture was there where I got bored or neglected the teacher 😉. You have the mesmerizing capacity to keep your audience glued to your lecture till the very end, and very few people in the world harbor this captivating ability... you stimulate me to study hard and harder. I can't thank you enough. Love you guys! Be blessed always. And keep teaching!!!

  • @piyapatel3193
    @piyapatel3193 Рік тому +11

    The excitement and enthusiasm to know this, rubs off!! Hats off to him🙌

  • @hemantnaik7466
    @hemantnaik7466 7 місяців тому +3

    Thanks

  • @tosanetsano2070
    @tosanetsano2070 2 роки тому +77

    I was literally just taught this topic this morning in my pharmacology class. Thank you for all you do, you guys have been a tremendous help in getting me this far in pharmacy school🙇🏾‍♀️🙇🏾‍♀️❤️

    • @veenapriyadarsini
      @veenapriyadarsini 2 роки тому

      I taught this topic to my students this mrng,i learn more from ur explanation

  • @Cole-mb8dn
    @Cole-mb8dn 2 роки тому +7

    This video is exactly what I needed for pharmacology rn! Crazy how Ninja Nerd just knows.

  • @devrajlamichhane4499
    @devrajlamichhane4499 9 місяців тому +1

    This is the best description and way of teaching Cardiac physiology and arrhythmias..... Thank you Doctor for Hard-work.

  • @eshetuseid3337
    @eshetuseid3337 Місяць тому

    this man is born to make things "super"easy and clear , great respect and appreciation from Ethiopia !!!

  • @nghiapham1644
    @nghiapham1644 Рік тому +4

    This is GOLD! Your enthusiasm is palpable! Thank you very much!

  • @gabbygtz7801
    @gabbygtz7801 2 роки тому +9

    Congrats on 2m!!🥳🎉 u guys more than deserve it! from the bottom of my heart, thank you Zach and team for everything that you do! idk how I would be getting through PA school without ur help! Ninja nerd for life:)

  • @errrccc
    @errrccc Рік тому +2

    This just cleared a lot of my confusion about anti-arrhythmic drugs. Definitely worth to watch! Thank you so much!

  • @johnerskine9792
    @johnerskine9792 Рік тому +3

    this is actually fantastic. It is genuine practical explanation and relevance to clinicians. It isnt regurgitating a textbook and you've really thought about how to teach. great work

  • @SARAHQUICKLOURENCODELIMA
    @SARAHQUICKLOURENCODELIMA Рік тому +1

    I seriously don't know what i would do without your classes.

  • @selvammuthaiya
    @selvammuthaiya 2 роки тому +6

    Thanks!

  • @Seda1979
    @Seda1979 Рік тому +2

    Good lecture Doc. I will say as someone who has taken both flecainide and currently propafenone this was very informative. HOWEVER, with propafenone it does have a minimum beta blockade effect as well. Grant it, it's not major but it's worth mentioning in full disclosure. I take propafenone for symptomatic pvcs, although now I am taking it post ablation,( which I had on March 17th this year while my heart recovers). Flecainide is a good drug, but it ran its course with me, (after 4yrs). I am 44yrs old. I thank GOD for my electrophysiologist who switched me from ditilazem to flecainide when he did. He is the same one who just did my cardiac ablation. NOTE: I had wpw, but that was ablated in 99 while I was a soldier at the young age of 20. Much of my pvcs came from that residual scar tissue from that first ablation. I hope and pray that I am done with ablations for the rest of my existence. GOD Bless.

  • @abdullahniaz7743
    @abdullahniaz7743 5 місяців тому

    The very precious human being on the earth Ninja Nerd the great. Salute to ur way of delivering lecture.

  • @franciscofierro758
    @franciscofierro758 8 місяців тому

    This is one of the most life saving videos I've ever seen. I'm gona donate something beceause this is better than paid stuff and its free. This channels and all the team are the best!!! Really gratefull.

  • @goseepy
    @goseepy 2 роки тому +1

    Can't thank you enough for these easy-to-follow lectures. So many future patients will benefit from this knowledge.

  • @linaziad8914
    @linaziad8914 Рік тому +3

    No words can describe my appreciation to you and your team thank you so much your videos are life saving thank you for all your effort

  • @IreneHeeney
    @IreneHeeney 11 місяців тому

    Fantastic lecture! Thank you! I'm a pharmacist, and your lectures are my go-to for CPD

  • @peterbarnabaskovacs7226
    @peterbarnabaskovacs7226 Рік тому +1

    Protect this man at all costs!

  • @doc599
    @doc599 Рік тому +1

    Besttttt lecture on UA-cam i have watched alott of lectures but i didn't understand....it was sooo confusing topic but you made it look sooo simplee..... thank u zack❤

  • @manyasfon
    @manyasfon 3 місяці тому

    I just got my “pass” on Step 1. I just want to thank you for your input - it can't be overestimated how much your videos helped to build the base.
    Best wishes to you and your team! You are amazing!

    • @OlufunshiAyo
      @OlufunshiAyo 3 місяці тому

      congratulations..I am currently preparing for my STEP one...please any suggestions? thanks

  • @felixquenneville981
    @felixquenneville981 Рік тому +1

    As usual, you make a complex subject crystal clear! Sure your videos are longer than most, but it is so worth it!

  • @lyuboslavlichev6454
    @lyuboslavlichev6454 11 місяців тому

    Honestly , one of his best lectures . Amazing

  • @linagudauskiene48
    @linagudauskiene48 2 роки тому

    The best teacher with the best teaching method l have ever seen

  • @fightersoul6436
    @fightersoul6436 Рік тому +1

    I can take only professor zach's classes continuously for hours, without losing focus for a min.... ✨✨✨...

  • @HEMZACHEMAA-i4z
    @HEMZACHEMAA-i4z 3 місяці тому

    Best teacher I found so far .
    Thank you

  • @roronoazoro3204
    @roronoazoro3204 Рік тому

    Ninja nerds videos are the only videos that I like before I even watch the video

  • @ametrinepatt
    @ametrinepatt 2 роки тому +1

    I don't take pharmacology but love listening to your voice before class, calms my anxiety 😅

  • @1998elif
    @1998elif Рік тому

    Im already finished with medschool but i still refresh with your videos.. amazing work thank you!!

  • @ScottSchellhammer
    @ScottSchellhammer 7 місяців тому

    Micturition reflex. Do not forget the muscarinic cholinergic effect on m2 receptors of internal urethral sphincter to relax it from S2S3S4 intermediate zone lamina 7 thru pelvic plexus to urinate. Thank you very much
    2:19

  • @mahfoudsmedicine8230
    @mahfoudsmedicine8230 2 роки тому +3

    I was waiting for this video, nothing to say but, you're the best.

  • @StellaJaeR
    @StellaJaeR 3 місяці тому

    Hey Zach, I'm not gonna stop commenting this. I'm still waiting for your antipsychotics and antidepressant drugs videos 😢 thank you for this informative videos, you are our hero ❤

  • @yachiapatel
    @yachiapatel 2 роки тому +6

    Can't be blessed enough to be born in the era where we have You 🌠🧿. You are our true Ninja, who just support and help us achieve our goals that too with ease. People with ninja nerd family always ask for more n more blessings for you Mr. Zach and may God shower all the love, gratitude and success to you 🥰🙌🎊
    And "as always until next time".💕

  • @rehababdelbagi
    @rehababdelbagi 2 місяці тому

    thank u soo much u made this extremely complex topic super easy and fun , i couldn't believe that i finally understand everything about it , U R A LEGEND

  • @remolabarca4959
    @remolabarca4959 2 роки тому +4

    Awesome lesson as always....thank you all

  • @MemeMania001
    @MemeMania001 6 місяців тому

    Your approach to this topic is a gem 💎

  • @amandavitaglian5859
    @amandavitaglian5859 2 роки тому +2

    You explain these topics so well! SO helpful

  • @WhyNot-si4pj
    @WhyNot-si4pj Рік тому

    1:47:45 The " proarrhythmic effect " of class 1C antiarrhythmic drugs is likely related to their effect of decreasing myocardial conduction velocity , which predisposes to myocardial reentry around and through regions of infarcted myocardium .

  • @nonamohemmed1129
    @nonamohemmed1129 2 роки тому +2

    Dude it's like you knew that I need this 😭😭😭😭😭
    Thanks ❤️❤️

  • @umurbatmaz9724
    @umurbatmaz9724 10 місяців тому

    I love how you explean it with passion. Thanks man!

  • @juvega2877
    @juvega2877 Рік тому

    I came here because I'm talking carvedilol and somehow it changed my heart rhythm even though the cardiologist says it didn't Now he sent me to the rhythm specialist to get an ablation... Anyway I came to educate myself... You're the best Ninja nerd 🤓

  • @naziazazay1558
    @naziazazay1558 2 роки тому +6

    Your lectures are really informative Can you please make videos on pharmacology of other systems too? Thank you.

  • @shadalkhan4783
    @shadalkhan4783 Місяць тому +1

    Zach we need you to teach more pharmacology PLEASE

  • @RachaelxCristina
    @RachaelxCristina 3 місяці тому

    Love watching your videos and drawing along/notetaking with you!!

  • @francescaitta4775
    @francescaitta4775 Рік тому

    Thank you for this Masterful explanation! I have no words to say but Thank You

  • @doskevin4882
    @doskevin4882 5 місяців тому

    Bought the membership. Worth it for sure

  • @sakshidahiya6802
    @sakshidahiya6802 6 місяців тому

    you are amazing thanks for you great hardwork,you explain everything from scratch.your channel is best

  • @frankasante139
    @frankasante139 Рік тому +1

    57:10 a little clarification needed here. It’s here that B1 blockage reduces phosphorylation of L-Type calcium channels I’m a bit confused as to how that affects phase 4 in AV and SA nodes what in there normal physiology it’s the T-type calcium channels that’s bring the MP to threshold. Can you clarify this for me 🙏🏾?

    • @sophie1e1e1e1e1e1e1e
      @sophie1e1e1e1e1e1e1e Рік тому

      Im asking the same question! haha i cant figure it out. I have read in a few textbooks and journal articles that B1-receptor agonism leads to increase Na influx throught the funny current (HCN channel), so i suppose if you block this effect this would lead to a prolongation of phase 4.
      But i am similarly confused as to why blocking L type Ca channels would lead to a prolongation of phase 4, more so then phase 0

  • @rishiraj2548
    @rishiraj2548 2 роки тому +3

    2M+ subscribers!!! Achieved!!!👍

  • @suboptimalzebra9284
    @suboptimalzebra9284 Рік тому

    Great lecture; about to start ACP school and this helped a ton. Huge thank you; well worth the time!

  • @physiokhankhan4729
    @physiokhankhan4729 2 роки тому +1

    You are great sir your lectures can make my concept really clear and i like the way that you teach to us
    Best wishes to you ✌❤

  • @jakewong6943
    @jakewong6943 Рік тому

    You are the best!! Thank you for these high quality and incredibly engaging videos. Always makes my day :)

  • @makeupgroupiesofficial4434
    @makeupgroupiesofficial4434 11 місяців тому

    EXCELLENT, EXCELLENT - THANKN YOU! I just became a member to download all the goods!

  • @your_babai_rj
    @your_babai_rj 2 роки тому +3

    Can you kindly discuss the Anti-cancer Drugs? Btw I have my Biochemistry VIVA next week. All your Physiology videos helped me a lot. Thanks.😊

  • @MuhammadYusuf-bi3ly
    @MuhammadYusuf-bi3ly 4 місяці тому

    C2 49:37
    Contra 2:02:25

  • @ehe3653
    @ehe3653 11 місяців тому

    Thank you so much for this! the questions at the end is really fun to answer after studying

  • @andreatobartorres985
    @andreatobartorres985 7 місяців тому

    Amazing unique FANTASTIC VIDEO FOR ANTIARRITMYCS FOR MY STEP 1 thank you so much

  • @apoorvasharma2827
    @apoorvasharma2827 5 місяців тому

    Thank you so much for this video. It was such a delight to watch. Keep it up..😭❤

  • @mokyuentin8962
    @mokyuentin8962 Рік тому +1

    excellent video. A in-depth explanation of all type of antiarrhythmic drugs. One thing I want to clarify, about the betablocker. In view you mention it will block the L-type Ca channel of the cell at the end, does it slow down / lengthen zone 0 longer instead of zone 4?

  • @evolvedone3493
    @evolvedone3493 2 роки тому +3

    Congrats on 2M I wish I could donate you but I will surely in future 👏👍🏻

  • @lazaroojeda3771
    @lazaroojeda3771 Рік тому

    Zach, in an earlier video you note that Mag given to severe asthma patients causes relaxation by its action on calcium channels. But here, when discussing TdP, you note that the mechanism by which mag works it’s unknown. It sit possible that they work by the same mechanism-namely, it’s effects on calcium channels?

  • @ilariaachillea
    @ilariaachillea 6 місяців тому

    all this useful knowledge for free, thank u so much

  • @كريمرواشده
    @كريمرواشده Рік тому +1

    Thank you for this great illustration.
    I’ve got a question ..
    Early in the lecture it was demonstrated that L-type Ca+ channels are responsible for phase 0.
    Later when you explained MOA of B-blockers ( that they block L-type Ca+ channels) , but the effect is manly on phase 4 of action potential not zero .!
    I wonder why is that the case ?
    I would be glad if you can explain it .
    Thanks again for your amazing lectures ❤

    • @youtuwatch3775
      @youtuwatch3775 5 місяців тому

      Not a 100% sure on this. But AFAIK phase 0 (rapid depolarisation) is largely due to the rapid opening of voltage gates Na+ channels. The L-type (L = Long) Ca2+ channels dominate phase 2 (the long sustained depolarisation), keeping the membrane depolarised even after the voltage gated Na+ channels close (they close very soon after opening due to their second gate(?)).

  • @inalaura9292
    @inalaura9292 Рік тому

    Thank you for your lectures. We would like to see and hear clearer the names of drugs you are taking about. Best wishes from patients. 💐

  • @linakamal2590
    @linakamal2590 10 місяців тому

    Best channel ever

  • @longoan7895
    @longoan7895 Рік тому +1

    thank you for the lesson, sir! I hope there are more video of cardiology

  • @patrickaustin3009
    @patrickaustin3009 Місяць тому

    You are a god among men sir

  • @RA-om8ck
    @RA-om8ck Рік тому

    Thank you Zach for your dedication and passion. I love details and you are a master in that! I always tell my class that if you want to get by learn the concepts, but if you want to make a difference or discover something learn the details. Hey I just discovered something - Double Quarter Pounder with Lecture and Fries Please. Mnemonic to remember the class I antiarrhythmic drugs. I love it!

  • @Thibxngwana
    @Thibxngwana 6 місяців тому

    You are an amazing teacher. Thank you so much

  • @emmanuelelijah3133
    @emmanuelelijah3133 2 роки тому

    Wow I was thought this topic today in the afternoon in med school, I'm preparing to write pharmacology test by end of this month. I pray I pass coz there are lots of things to know like drugs and mechanism

  • @HAIDERALI-he9fh
    @HAIDERALI-he9fh 5 місяців тому

    Thank you for providing great concepts 🙂

  • @meimei9057
    @meimei9057 2 роки тому +2

    Thank you dear!Nice explantion!

  • @learnplex4914
    @learnplex4914 Рік тому

    Beautiful Explanation. Just Loved It❤️ You always make textbook reading very simple.

  • @dastanmirzambetov6191
    @dastanmirzambetov6191 Рік тому

    Your help made me interested in medicine more than before

  • @Rasha.Ishtar
    @Rasha.Ishtar Рік тому

    Thank you Zach you are the best ❤

  • @g.kgadri6655
    @g.kgadri6655 Рік тому +1

    Guys, YOU ARE AWESOME.... IT IS ALL COMING TOGETHER NOW...!!!!!

  • @SamanPiroti
    @SamanPiroti 11 місяців тому

    this lecture was amazing thank you so much Zach!

  • @akifgunay6650
    @akifgunay6650 Рік тому +1

    great video, tremendous work.

  • @admeliora3962
    @admeliora3962 Рік тому

    i heckin' love prof. zach

  • @MikeyGoobie
    @MikeyGoobie Рік тому

    Thank you very much for all the help. ❤

  • @Xx_Eric_was_Here_xX
    @Xx_Eric_was_Here_xX 2 місяці тому

    i was considering going back to school to study electrical engineering (i currently have a 2-year degree in maths). however, in my free time, i tend to spend a lot more time watching videos like this (and taking notes!) than i do learning about electrical physics and programming. maybe it is a sign of something i should study instead? anyway, i really appreciate your content.

  • @ShemMwangi-no8nz
    @ShemMwangi-no8nz 5 місяців тому

    praying for more blessings,, thank you ,,, streaming from Kenya

  • @d.j.martin
    @d.j.martin 9 місяців тому

    I think you a probably a gift from God. Thank you!!
    Such a helpful video!!

  • @wilsonknowles9398
    @wilsonknowles9398 2 місяці тому

    Might be a stupid question, but what causes the initial movement of sodium into the cell through the funny sodium channel? A nervous system transmitter or something?

  • @IRishabgoyal
    @IRishabgoyal 11 місяців тому

    In your video particularly at 8.27 you mention that voltage gayed na+ channel open and it open ca2+ but in diagram you not mentioned any na+ voltage channel that open at threshold

  • @najwafaiz5717
    @najwafaiz5717 5 місяців тому

    Hello- beautiful video! Quick question - at around the 1 hour and 13 minute mark, you said "these can, to a very mild degree, block voltage-gated potassium channels". Should this have been voltage gated calcium channels (in reference to adenosine and digoxin)?

  • @sophielunnac
    @sophielunnac Рік тому

    thank you perfect video ! can someone answer this :
    slowing down the influx of sodium ions into cardiac muscle cells causing a decrease in the excitability of the cells it has a beta adrenergic blocker which can cause bradycardia and bronchospasm :
    sotalol
    propafenone
    verapamil
    mexitilene

  • @tamngoc6046
    @tamngoc6046 8 місяців тому

    Thank you very much Ninja Nerd

  • @MyLe-xy1un
    @MyLe-xy1un 10 місяців тому

    I am learning so much, thank you good Sir.

  • @AadilKhan-mb5ic
    @AadilKhan-mb5ic Рік тому +1

    Outstanding ❤