Around 13:47 it has been mentioned that PKD is not the only *disease of Primary Cilium*. But previously it was mentioned that primary cilia have no sensory or motile function. While At the collecting duct it does show sensory function. So can you tell what exactly is PKD caused by?
Hi, the primary cilum has "sensory" roles and are non-motile. It senses the flow of urine through proteins which regulate calcium levels. Calcium ions seem to control several downstream molecules leading to cyst formation. Without sensing, cilia can't do all these functions, right?
13:00 Is it possible that the misdirected diuretic signal to draw water from plasma is also responsible for kidney stones?
Fantastic! Must reviews for nephrology fellows and practitioners
Fascinating subject, thank you very much for making this!
Very useful, would be greately appreciated to have an explanation of the function of cilia in other tissues.
Around 13:47 it has been mentioned that PKD is not the only *disease of Primary Cilium*.
But previously it was mentioned that primary cilia have no sensory or motile function. While At the collecting duct it does show sensory function.
So can you tell what exactly is PKD caused by?
Hi, the primary cilum has "sensory" roles and are non-motile. It senses the flow of urine through proteins which regulate calcium levels. Calcium ions seem to control several downstream molecules leading to cyst formation.
Without sensing, cilia can't do all these functions, right?
That was fascinating. How much is known about the primary cilium in the cerebral cortex?