Debunking Health Myths: Truth About Oreos, Heart Disease, Cholesterol & Keto Diet | Dave Feldman
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- Опубліковано 3 бер 2024
- The current thoughts around LDL cholesterol center on the fact that there is no scenario in which high LDL numbers could occur in healthy individuals. Traditionally, the belief is high levels of LDL can lead to a greater risk of cardiovascular disease regardless of metabolic health. Today’s guest is here to share his hypothesis and research on how higher cholesterol levels in metabolically fit individuals could be a physiological response rather than a pathological response that can lead to disease.
Today on The Dhru Purohit Show, Dhru sits down with Dave Feldman to discuss high levels of LDL in metabolically healthy individuals. Dave shares the current research on high LDL and cardiovascular disease in individuals eating a ketogenic diet. He also shares his personal approach to focusing on metabolic health and the key markers critical to overall health. Dave discusses the process and findings of the Oreo experiment conducted by his colleague and explains why this experiment further proves their hypothesis on how LDL particles move through the body.
Dave Feldman is a software and platform engineer, entrepreneur, and founder of the Citizen Science Foundation. His life took a radical turn upon seeing his cholesterol skyrocket after adopting a ketogenic diet, and he became obsessed with understanding why this is common with those who are likewise leaner and more metabolically healthy. Through a series of self-experiments and partnering with formal researchers, he has since published the "Lipid Energy Model," which may explain this phenomenon.
In this episode, Dhru and Dave dive into:
-Dave’s hypothesis on LDL
-Rethinking our approach to high LDL
-The research on high LDL and cardiovascular disease
-The Oreo experiment and what it shows about fat adaptation
-The pushback to lean mass hyper responder
-Soft plaque versus hard plaque and the risk of cardiovascular disease
-Dave’s personal approach in focusing on overall metabolic health
-Fasting Insulin and Vitamin D
-Endothelial health and cardiovascular health
-The vegan’s twin study and the correlation to LDL
-Dhru’s experience
Also mentioned in this episode:
-Citizen Science Foundation: citizensciencefoundation.org/
-Oreo Cookie Treatment: www.mdpi.com/2218-1989/14/1/73
-Nicolas Norwitz, PhD Twitter: nicknorwitz?lang=en
To learn more about Dave:
-UA-cam: / @realdavefeldman
-Instagram: realdavefel...
-Twitter/X: realdavefeldman?l...
This episode is brought to you by:
-LMNT: DrinkLMNT.com/dhru
-Momentous: livemomentous.com
-Lumebox: thelumebox.com/dhru
Right now, LMNT is offering my listeners a free sample pack with any purchase. Head over to DrinkLMNT.com/dhru today.
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Prior to the1970's and the advent of statins normal cholesterol was 300 and then was dropped to 200 since the drug company had a way to drop it.
I seem to remember that
The total or the LDL?
@@elgueyes4788 Total
I'm guessing total ?
Key takeaways:
1. **Challenging LDL Cholesterol Assumptions**: Dave Feldman proposes that high LDL cholesterol might not be harmful in metabolically healthy individuals on low-carb or ketogenic diets, suggesting a need to revisit current health guidelines.
2. **Research and Controversy**: Feldman's hypothesis, inspired by personal observations and preliminary studies, calls for further research into the relationship between high LDL cholesterol and cardiovascular risk in metabolically healthy individuals. This includes conducting studies like the one at UCLA and the controversial Oreo cookie experiment.
3. **Lipid Energy Model**: This model suggests that LDL cholesterol levels are influenced by energy metabolism rather than just dietary fat intake. Experiments, like the one involving Oreo cookies, indicate that high carbohydrate and sugar intake can significantly decrease LDL cholesterol levels, challenging established beliefs about dietary fats and processed foods.
4. **Importance of Apolipoprotein B and Metabolic Health**: ApoB is highlighted as a more accurate biomarker for cardiovascular risk, with changes in lipid profiles indicating shifts in metabolic health. The lipid energy model and discussions around apoB provide a more nuanced understanding of cardiovascular risk beyond just LDL cholesterol levels.
5. **Endothelial Function and Plaque Formation**: The process involving inflammation and endothelial function in plaque formation is complex, indicating that LDL cholesterol's role in heart disease is conditional on other factors like inflammation and endothelial health.
6. **Impact of Diet on LDL Cholesterol**: The comparison between plant-based diets and omnivorous diets in terms of LDL cholesterol levels underscores the influence of diet composition, especially carbohydrate and fiber intake, on lipid profiles. However, overall cardiovascular health depends on a broader range of factors including diet, physical activity, and metabolic health.
7. **Personal Health Journeys**: Feldman shares personal experiences with diet, health conditions, and managing lipid levels, emphasizing the importance of personalized health approaches and the challenges in disseminating scientific knowledge to the public.
8. **Advocacy for Open Inquiry**: Feldman encourages skepticism and open-mindedness in scientific inquiry and public discourse on health. He invites public participation in research efforts through the Citizen Science Foundation and highlights the role of community and funding in advancing scientific understanding.
Scientific Methodology is required, of course. 😮
Thank you for the info. This is something I was struggling to figure out for the last 12 months since I started the keto diet.
My health improved remarkably, HDL shot up, triglycerides plummeted
However LDL was also up by 80%.
I searched for answers but found nothing.
This podcast shed much needed light into this unexplained phenomenon and I’m so grateful for
Here’s the question that Dr. Malcom Kendricks asks. Veins and arteries both involve blood flow where the LDL concentration is the same. Why is there no plaque in the veins? Veins are used in heart bypass surgery and may later develop plaque.
One of the reasons is veins have a much lower blood pressure than arteries.
Yes that came to mind. But what component of blood drives that process? Size of LDL particles? High glucose?@@gtm5650
Large blood vessels in the body are supplied with nutrients via their own, small, blood vessels known as vasa vasorum. Literally, blood vessels of the blood vessels. These are arterioles, and capillaries, that penetrate/permeate the vessel wall.
These very small blood vessels, lying within the artery wall, have fenestrations (holes) and loose junctions that allow the free movement of LDL - in an out of artery walls. So, any LDL in the bloodstream can quite easily enter the artery - and exit the artery (and the veins) - without having to cross any barrier at all. have more vasa vasorum than arteries, so this if this is the route for LDL to enter blood vessel walls, then veins should have more atherosclerosis than arteries, which they do not. In fact, veins never develop atherosclerosis - ever.
Fantastic explanations Dave Feldman!
Wow!! Thank you Dhru, I have been waiting for this podcast with Dave Feldman!!!
Did Nick’s triglycerides go up when his LDL went down?
I'm not willing to take statins. I do have over 200 in LDL, but my HDL is high and my triglycerides are normal. My blood pressure is normal about 125/75. I am not convinced that anything is wrong with my heart health. Thank you for this information. I think it's necessary to update the research.
How did Nick's apo b come down with the cookie experiment?
You would think the Daily Mail/mainstream media would be all over this!!! Headline news about Oreo vs Statin!!!
Not heard a word 🤔
Thank you am ok now thank you
Still waiting for Dave and Nick to get into the topic of oxidized LDL… 😢
I remember your the one with l d l about boats
Am I getting better now boatman
Put dr berg on when I get treatment am not exercising anymore toget hurt
High ldl gives sign , not fire but smoke I am metabolically super healthy fasting insulin 88, bimi22, 170ldl , calcium score 590 , crestor 20mg now ldl 73
Blood work was good couldn't get out of bed 10 medications went carnivore jogging now off all medications blood work looks bad for cholesterol not going back
Not on twitter
Nicholas Norwitz has an excellent UA-cam channel.
It's dr berg pancakes almond flour and stevie there delicious
Please discuss keto 🥑🥓🥚🧀 and intelligence with keto doctor
He said im another podcast 12 Oreos a day
Am hurting dr l d l man am in pain
Be more scared of the 💉 then saturated fats and cholesterol
This is more of a question than a statement., What I find truly interesting is their choice of Oreo cookies with this quick study. I decided to do a deep dive into Oreo cookies and the ingredients in them. Their choice of Oreo cookies almost seems deliberate because of the ingredients, which I will list. The reason it seemed deliberate is because the ingredients actually do lower LDL (bad) cholesterol and raise HDL (good) cholesterol , I believe they had to know this going in; Tell me why they would use an Oreo cookie to do this kind of study unless they knew about the ingredients that happened to change cholesterol levels, NIACIN, REDUCED IRON, THIAMINE MONONITRATE, RIBOFLAVIN, AND COCOA have the ability to lower bad cholesterol and raise good cholesterol. The bad thing is that all the other ingredients are not a good choice for a healthy body, at least for most. I am a student studying functional nutrition, am I missing something here?
🤣🤣🤣🤣🤣🤣🤣🤣🤣🤣
Couldn't it Just be rationalization?
We were healthier before "Science" became our new religion. The problem is the Scientists don't know what they don't know. Looks like what the Oreo experiment proves is that "carbs are essential". He needs to do the experiment again and eat a sweet potato instead. I expect the bad cholesterol would drop even lower.😊
And the rest of the world like Indonesia are following what the Americans do ....
Yes, it works with any carbs. Those experiments have been done by individuals. But for some people, like Nick who did the Oreo experiment and for many that are using the ketogenic diet for other health reasons (i.e,=. epileptic seizures, bi-polar, schizophrenia, etc), it is essential that they stay in ketosis. Most people on a ketogenic diet eat some healthy carbs, but not enough to not produce ketones.
I don't drive I get ambulance transport for my eye injections in both eyes
No
I don't want you hurt me please
Don't hurt me boat man carriage
Dr berg talk to me
No am asma I panic no
No cookies am diabetic no thanks
Why is anyone interested in a software programmer's opinion about metabolism, biology, or health? He states that he knows nothing about biological or medical research.
Who will you be interviewing next? Your mom?
Omg Dave I’ve listened to you trying your explain this ldl cholesterol phenomenon on so many podcasts! It’s so awesome that you did this study but stop qualifying your explanation snd back peddling!!! Just spit it out straight!!! Stop going in to engineer speak!! I can’t listen to you any more!!! You start out fine and then get confusing!! Explain it to me like I’m kindergartener!!!
I thought it was pretty clear😅
Hm. Talking about LDL as a whole is a gross oversimplification of the issue with CVD. If your ApoB gets higher with keto, then you are playing a dangerous game!
I won't eat fatty food bad for your heart
The LMHR group eat high fat and low carb. The study will DIRECTLY address that hypothesis although almost every actual study (not epidemiological questionnaires) already show that eating fat isn't atherosclerotic but hyperinsulinemia is.