Maybe i am an outlier but Ozempic helped me put my habits in place, used for 3 months to lose 8kg and stopped it because of $$$, for 5 months after i am down 16kg and in a healthy weight.
Ok but did you learn anything. Did you learn hoir macro nutrients, your maintenance phase or your meal timing. I highly doubt it. It's easy to lose, it's harder to keep it off. Learn of to keep it off or it will come back.
Thank you Thomas, for sitting there SOOOOO patiently, allowing this brilliant man to speak at length, with the freedom to veer off track, in order to further explain complicated, but important, aspects. YOU have my sincerest respect. This is why I subscribe to you! You are as interested in learning, as your audience, not just in hearing yourself speak. THANK YOU!!!
Resistance training plus adequate protein alleviates the lean tissue loss. ANYONE, regardless of the modality, will lose lean tissue if weight loss occurs absent adequate protein and resistance training. I monitor my patients closely on GLP 1 RA's and our main topic at visits is: how much protein are you eating? How much exercise are you doing? These are people with diabetes, not for weight loss. It can be profoundly beneficial in that population. Don't let the misuse for weight loss purposes overshadow why this class of drugs was developed: type 2 diabetes.
While I have to thank you for mitigating some of the harm that these drugs can cause, it's a bit eye-brow raising to make a comment about how normal weight loss is with this drug when most of video is about how it is anything but normal. Dr. Bikman raises quite a number of issues with the dosing (which is different from what's used for diabetes management), mechanism of action, patient initiated drop out rates, what happens in a reasonablly short time frame after quitting, and a few other topics. The doctor speaks with more clarity and brevity than I've seen yet on this topic and he even makes some concessions and admits when it's not all bad. I'm sure you're extraordinarily busy with your practice but when someone raises some fair points I think it's worth acknowledging that.
The problem is that misuse IS overshadowing their use responsibly. Loads of influencers, media, etc frame GLPs as a long term weight management drug. And obviously the manufacturers want as many people as possible taking them for as long as possible so they aren't going to step in and tell people to stop being irresponsible. I agree they're great initially for someone with diabetes to get it under control faster and whilst they learn to eat a no carb diet. But that person resolving their health through diet and not needing these drugs should be the long term goal.
@@TG-vg3qeI think the studies show that it’s the resistance training not protein. You stress the bones with weight training and that forces the bones to stay stronger in order to address that stress.
31:16 Before I ordered a pricey Caesar salad in a restaurant last month I asked the server to find out if it was JUST olive oil in the dressing (which is the only oil it should have), because, I told her, I'm allergic to Seed oils. She returned 10 minutes later - "Sorry Ma'am... it's got canola oil in it." EVERYTHING now has cheap seed oils in it. The best fish and chips I ever had were back in the 60s in San Francisco - all cooked in tallow.
They key takeaway I got from this is, eating seed oils causes peroxidation. Peroxidation is damaging, and encourages fat cells to grow, and the type of fat that grows encourages insulin resistance. Insulin reistance will increase your appetite, because your cells are resisting the delivery of energy. So in turn you end up eating more of the seed oils creating a self perpetuating cycle of weight gain and poor health. The only way out is to remove Ultra processed food, avoid seed oils, lose the fat that is encouraging insulin resistance and fat storage.
I haven't eaten any seed oils and kept my PUFA intake extremely low for the past 3 years. I still am overweight and have insulin resistance. For me it's the carbs keeping me this way. Granted I am not obese, just overweight but with very high fasting insulin.
@@Lopsa192 To lose weight you need to be on a low inflammation. Say seed oils are 50% and carbs are 50%. If you remove seed oils you are still 50% inflamed so can't lose weight. If you remove carbs and seed oils youll be at 0% and can now lose weight. If you remove carbs but eat seed oils "dirty keto" you can still lose weight but it will be slower.
Only thermally oxydized seed oils cause peroxidation. And oxydation occurs only with repeated heated so seed oils outside of some UPFs are not dangerous
@@vaevictis2789 So the deep fryers at fast food restaurants where they keep reusing vegetable oil or peanut oil all day is more dangerous than just using a little splash of fresh seed oil at home?
Love Dr Bikman. Been an athlete my whole life and always ate pretty heathy BUT struggled with weight and always had a huge appetite and barely had a satiety signal. These GLP-1 helped where diet lifting weights, running and starving myself could not budge the scale. People need to be educated that lifting weights is a non negotiable on a GLP-1 and most people will need to stay on a GLP-1 to some degree long term to maintain a healthy weight. 🙌I’m 53 5’1” and I lost 50lb and gained lean muscle and strength using GLP-1. Hardly had a negative side effect. Maintaining well over a year at 113lb. Helped me to improve insulin sensitivity manage appetite and satiety. Have done 2 DEXA scans confirming muscle gain, 10%Body Fat. Exclusively work out at home. Sharing my weight loss & fitness journey on my UA-cam channel💪
@@theoneandonly1158I think we all have the potential if we have the desire to learn and apply what we learn. This is the whole reason for my YT. Is to help empower other people with the right knowledge you too can get healthy lean and strong AF
Good explanations but what you are NOT saying is that these same issues occur for almost anyone that goes on a low calorie diet with out exercising, and the majority of people who lose weight do gain it back because they didn't change their eating habits. Stop the scare tactics about this particular compound. Also - you mention that 70% of people voluntarily get off the compound - how many of those were because they could not afford to stay on the shot.
The difference is that those of us who lose it naturally actually learn something in the process, and develop self discipline. Verses people who inject to erase appetite and cravings. Sorry but no, the failure rate in terms of regain is going to be higher in the people who didn't do it naturally. It's all about actually working for it. You don't just casually undo all that actual hard work. Speaking from experience
@@heythere5817 Nonsense. If that’s the case why do 85% of people who lose weight (regardless of how they do it) gain it all back? The statistics don’t lie.
@@heythere5817 up to 95% of people who lose weight with diet and exercise will gain back all the weight within 5 years. So it's not unique that GLP-1s also fall in this category.
Many like me went off voluntarily. Not for the cost, I'm Italian and registered as diabetic so I get it for free. It's the side effects that scare many people...and having turned Carnivore helped me not needing this crap anymore 😅
I agree here - strongly. If „facts“ are stated like the rate of people who stopped the drug, what were the reasons? And how many cases have been reported where patients received a low dose of the drug? Misuse or abuse of any drug will increase the side effects. Nothing new here. So maybe doctors could me more educated on how to dose the drug actually.
As a type 1 diebetic who also got type 2 over the years, I can say glp1's helped my diabetes by a bunch. I had so much insulin resistance, I was taking over 150 units a day. No matter how much I worked out or dieted I could never lose weight, I would still gain weight. Now I take 1/3 of that insulin and no longer need blood pressure meds just after 4 months. Also down 40 lbs. The key is to not titrate up too fast on the dose and change shot locations.
I've only known type I diabetics who took their health very seriously and watched everything that they ate except on girl who unfortunately had a mother who baked a lot. She lost her eyesight in her 20's.
I’m 52, went on Ozempic, lost 10kgs and got my blood sugar in normal range. Stalled. Have 10 more kilograms to go so have stopped Ozempic and switched to keto and transitioning to carnivore. Just as good to control hunger and cravings with no nausea etc. I train with weights and prioritize protein (since I was 18) so no muscle loss
Thats Awesome! At 51, I started following Thomas for a year and a half now. Down 100lbs. I went from 353lbs to 253lbs. I was a prediabetic mess with a diagnosis of psoriatic arthritis. I didnt feel like doing anything! Now I do resistance training, lots of walking. Usually I eat keto or ketovore. I have stalled at 250lbs. Occasionally, I might drop down to 248 or so, but I can never seem to maintain it. I just keep telling myself that I have made a change in diet and lifestyle, and it is where I feel the best. It doesn't matter how long it takes. Wish you the best! 😊
@@RLeeErmy Well done. 👏🏼Yeah stalls happen and it might be worth getting another perspective to help you solve it. I’m joining Kelly at My Zero Carb Life for the month of November to help me step it up. It’s just $50 for the month. Perhaps consider joining?
I’m 49 worked out 5 days a week and was 226. Achieve 175 at one point eating fairly good. Lost my way and sit to 230. My point is I ate better whole foods. Lost 39 lbs which I had lost in 3-4 yr period. My point it is when I started eating better cutting process food and process sugar I had better weight loss. I’m healthy now the. I was at 175 lbs and had so much muscle. The best point is eat better not using these drugs. My am still in my journey. I’m set to lose max 15 lbs. i’m 190 lbs from 228. I’m able to play tennis with my kid better than when i was prior at 175lbs. So the key is diet or in other words eating better. If drugs work for you they should be only temporary used with caution.
Am on GLP1 with instructions to lift weights, eat protein, review emotional management..so benefits are to get weight normal, sleep, come off pain meds and reduce all risk mortality....Expecting to come off it in 6 months. .also expecting it to be as difficult as it was before to keep the weight off....story of my life....but my body has been fighting weight loss due to menopause and my physiology... My cravings have disappeared and I don't feel sick at all 😊 These drugs need to come with instructions to change/improve habits
Agree. I have the same experience. Food noise almost gone and I do not feel sick. Not to mention the pain in my body is gone and there are other significant benefits too. Not everything said in the first 11 min of this video is on point. I rarely comment on a UA-cam video. Let's not keep the obese people down. There is clearly a problem that the health & fitness industry is not able to fix. It has continued to get worse for decades.
As a cell scientist working in conjunction with other professionals around this issue, for obesity please, please someone spend some time looking at ‘why’. As soon as it comes back to ‘learning to eat differently’, ‘discipline’ etc. the boat has been missed. When it comes to life long struggles with significant weight control, this is an early developed trauma response where something neurological has gone off the rails. Until there is a focus on how to manage that, there will continue to be more decades of effort down the wrong path.
Hi, I am a neuroscientist that is also looking into the potential effects of neurological/psychiatric disorders on obesity. What you mentioned is quite interesting, do you have reference journal articles for it?
Ive just started it. My parents died in their 60s of stroke/heart attack. Ive been the same 4.5 stone overweight all my adult life, im 60 now. Mounjaro has given me wright loss and at lady, my mind is not at war constantly battling not to eat. Ive upped protein levels, added in resistance training. Yes i worry about stopping Mounjaro, but failure rate is 70% versus 95% for traditional diets. Its better odds.
I felt so horrible on Ozempic, aside from the atrocious cost (even here in Canada), at the lowest dose in the pens I felt bloated and nauseous all the time, like 5 bites of dinner and I was done. Not because I wasn't hungry, I was in extreme discomfort. I was getting so depressed, I had to quit. It took months before my digestive system felt normal again. I can eat my entire meal and not feel like crying. Yes I have diabetes and I need better control, but if I feel more horrible on the drug what's the point? No thanks.
I had a gastric bypass 25 years ago. I was not diabetic. I immediately lost what I will call food craving but basically I just felt like I had a normal appetite. It wasn't that I couldn't eat because I was too full, I never felt like overeating. I kept telling everyone who would listen, this is what normal people feel like. No one, including my doctor, seemed even slightly interested. I'm glad you have found the science behind it.
I thank God that I remain healthy after all the crazy things I did to my body over the last several decades to be thin... and I am typing this to share that the best, most effective way I have learned to lose weight was to buy a little notebook and *_HONESTLY_* keep a daily calorie counting journal of everything I put in my mouth and targeting a calorie intake slightly lower than my output. By acknowledging and managing my calories by balancing my nutrition to nourish and *_fuel_* my body's needs and appetites, I lost 25lbs slowly and forced myself to confront my eating impulses and manage my health with better choices.
My parents lived in Belgium in the 80’s and you could find frite (French fry) stands in the countryside where they made fries in farm stands with animal fat. They served them with mayonnaise that they made fresh themselves. They had something called ‘sauce americaine’ that was ketchup like. It was the first time I ever liked mayo in my life. Those fries were the very best in the world.
I used it for one month but had 5 major side effects and then discontinued. However, coupled with the change to a keto like diet it did enable me to make the transition without the torture of continual hunger pangs. So now 40 lbs lost in 4 months and blood work is fine - down from 7.9 A1C to 5.6 in 3 months.
Ok but did you learn anything. Did you learn hoir macro nutrients, your maintenance phase or your meal timing. I highly doubt it. It's easy to lose, it's harder to keep it off. Learn of to keep it off or it will come back.
The same could be said with weight loss by any means. It’s always easy to take it off yet very difficult to maintain. Whether you’re taking a med or not you have to do the inner work and get your body used to, and in love with, movement. The meds can help some people get started.
As a 75 yo type 2 diabetic stopped using Ozampic, much improved quality of life. Low carbohydrate diet and low insulin dose high protein/fat and vegetables with 120 km a week on the bicycle losing weight good blood sugar.
GLP med keeps me on a steady carnivore path and is changing my life. I’ve lost 120 pounds so far. The amount of lean mass lost is equal to weight loss surgery, and no one complains about that. Easy solution…Lift weights.
So good to see a host who is quiet while the guest is speaking, paying attention and taking notes for the following questions instead of being the whole time just interrupting with useless "yeah... Sure... Of course..."
24 дні тому+6
I can hear Mr Bikmam's talks and interviews again and again 👍
Thomas, I always appreciate your thorough approaches to research and information. I declined a college education to pursue personal goals. I dont endorse this plan for others but for me, it was good. I committed to being self taught. People like yourself have made the journey very fulfilling. Keep up the good work. You are helping many of us. Im 61 and in the best mental and physical health of my life. Kudos
If you live in the state of Utah and want a great french fry; Go to Redmond Farms in Orem and get their coconut fries. If you own a fast food place, please consider going to beef tallow or coconut oil. Charge a slight premium and help our country get healthy (er).
I never get tired of listening to Dr Beckman !! Soooo much information. I know several people who were on ozanpic stopped it , did not change their eating habits n gained it all back n more when stopped taking.
I have used tirzepatide last year for ~4 months and lost in total 70 lbs, BMI now at 21. (not all due to Tirzepatide (maybe half of it)). It has been 1.5 years, and I am still maintaining my weight. If you use GLP-1 drug to help you getting to your goal and at the same time change your diet, is this not what we want? I chose to stop the injections because I was where I wanted to be not because I was feeling sick. Note that I kept my dosage at
I started questioning everything, especially government health advice! After reading "Health and Beauty Mastery" by Julian Bannett, I completely changed my habits. This book reveals so many shocking truths about the health industry!
I’ve learned so much from reading Dr. Bikman’s book, How Not To Get Sick, but I have to disagree with what he says at 11:03. My food noise, aka cravings went away and it wasn’t because I felt sick or nauseous. I’ve been on Zepbound for 8 months and I’m still on a low dose (5mg- the second dose on the titration schedule). I’ve lost 65lbs, improved my a1c, eat 100-130g of protein daily and loose about 1- 1 1/2 lbs a week. I agree that some on this medication are on doses that have completely destroyed their appetite and cause GI issues, but in most cases the problem isn’t the medication itself, it’s the dosing schedule. Many of us are using this as a tool in combination with lifestyle changes. Starting this medication has been the best thing I’ve done for my health. Just my 2¢ 😊
I watched the entire length of the video but couldn't find any revelations that haven't been known since these drugs launched like a decade ago. Yes, you regain weight after stopping these drugs IF you havent used them to modify your behaviour and changing eating habits, you lose muscle mass on any weight loss program IF you arent strength training and increasing protein intake. I took GLP-1/GIP for 18 months at the max dose and then tapered down to a maintainence dose of 2.5 mg over the next 6 months and am still losing some weight BECAUSE I was able to fix my lifestyle and start strength training. There is no "unpopular" truth in this video, all well known things that happpen and the things that your doctors will discuss with you before you go on these medications (if they arent change your doctor). I am sper excited about Retatrutide and Mazdutide which will be coming to market over the next 24 months and be even more effective.
@Ronibearable I think you are confusing dosage for ozempic, I am on tirzepatide and the lowest dose for it is 2.5mg both for diabetes and weight management, also I take one shot of the lowest dose every 2 weeks and it has been excellent for my blood pressure, glucose control, weight management and also been sober for 3 months now - I love tirzepatide although do plan on going off it in about an year.
@@Ronibearable I did mention glp1/gip but all good, the important thing is that the medications are working for us and every doctor worth their salt will curate a personalized plan for their patients on these drugs and these are safe for long term use and maintainence and alarmists like Bikman need to realize the harm they are doing by overstating the negatives to push their metabolic programs ( I believe he is on the board of levels and another similar program)
I occasionally make French fries for my sons. I start with potatoes, fried in tallow, I rendered, and sprinkle with sea salt. They wondered why they had never tasted anything like this before. Only way they eat French fries now.
"it's the nice way of saying I feel sick to my stomach all the time" -- this is absolutely 100% correct and exactly my experience. I was only on it for a month and a half. It was a very nice tool to release the grip of food addiction but boy did it make me feel bad.
I'm on Wegovy for 5 weeks now and haven't experienced a single side effect. It's stopped my cravings for food and I don't overeat anymore. I've moved from 0.25mg now to 0.5mg per week, but I'm not going to titrate the dose up any further as it's doing its job nicely at these low levels.
For me, losing weight is easier than keeping it off. Down over 100 lbs. from 11 years ago. BMI this morning was 22.7. Time for the daily mile and half walk.
My friend is diabetic. She's been prescribed Ozempic. She struggles to get the meds because the high demand. Some of the pharmacists require her doctor to call them to explain the necessity of the drug for her before they will prescribe it. She has gone weeks without her medication because they are out, or they have additional hoops to jump through. Of course, they don't tell you the additional hoops until you call wondering why it's taking so long to fill the prescription you've had for months.
He almost touched on an important point, but then missed it: the GLP-1 stimulus from meds like ozempic is not comparable to endogenous levels. Discussing what foods have what impact on GLP-1 is completely misleading because no foods increase GLP-1 anywhere near what you get from the pharmacotherapy. Translation: foods that “increase glp-1” are not Ozempic substitutes and they don’t induce weight loss. Like he even pointed out earlier in the conversation, even lower doses of ozempic don’t induce much weight loss, and those low doses are still orders of magnitude higher than you will ever get from a steak dinner. What we discovered is that there is an effect of GLP-1 that emerges at concentrations much higher than you would ever encounter naturally. That’s why these medications work and diets don’t.
@ as an intervention, diets have a terrible track record. Modest weight loss that isn’t sustainable. Do you know how few people can maintain a carnivore or keto diet long term? Very few.
20:36 I'm of an advanced enough age to remember over the counter diet pills. Essentially it was speed. What they did was curb your appetite, quite effectively! And while they were eventually withdrawn from sale/use, I don't recall the side effects being anywhere near the laundry list associated with GLP1 drugs. Learning to eat a proper human diet, devoid of or tightly restricting carbs, is the natural, non side effect means to health, including weight loss.
As a pharmacist who uses these medications, his characterization that it reduces appetite because it makes you feel a little sick is just flat wrong. And that fear almost kept me from trying this life-changing medication. In reality it just makes you think about food less, it reduces food noise and appetite, and it makes you feel satisfied sooner. It works exactly how you would hope a weight loss medication would work. Some people experience nausea. But don’t confuse the side effect and the actual pharmacological action. They are categorically different and the one doesn’t follow from the other. I rarely have any nausea, but my appetite is clearly diminished despite no nausea.
My husband never had the nausea. But 2 weeks ago he had to be rushed to the hospital because of gastroperisus(don't know how to spell that). Surgeon told him it was caused by the ozempic! Scary!
I’d also add taking too high of a dosage effects how you feel. Plenty of people actually add muscle while on these medications. In addition, ANY weight loss (medicated or not) can lead to muscle loss if you’re not eating appropriately and lifting heavy enough weights that trigger your muscles to maintain. I think Dr. Bikman is great and I’ve listened to him for a few years now. He makes learning about insulin and all that goes with it, easy…. but I will completely disagree with him on this.
It slows down the gastric emptying, if you feel full you don't think about food. But I felt bloated all the time. Semaglutide delays gastric emptying and may affect the rate of absorption of concomitant oral medications. Semaglutide should be used with caution in patients receiving oral medications that require rapid gastrointestinal absorption.
@@dlyose Semaglutide delays gastric emptying and may affect the rate of absorption of concomitant oral medications. Semaglutide should be used with caution in patients receiving oral medications that require rapid gastrointestinal absorption.
My husband is on Ozempic , a little over a year now. Some of the side effects have subsided, nausea still from time to time. He’s lost a lot of muscle and he craves sugar, he eats way more sugar than protein and tired a lot
Ugh me too. Off 9 months. I still have major anxiety and my sugar cravings are way higher than they ever were. I recently started carnivore but so far the sugar cravings are still crazy. Oh and I’ve been off it 9 months. It’s not worth it!
Please, please, please try and get him to eat a cooked breakfast with plenty of meat, eggs and maybe tomatoes, mushrooms etc (or similar). It will help stave off his hunger and cravings. Then, slowly add in more protein and less carbs to each meal. I find it's better to slowly adjust your body and change your gut biome so that your body stops craving the wrong stuff. I hope you don't mind my suggestion.
Regarding the return of sweet cravings returning to pre drug levels, couldn’t that be independent of the drug? I.E. a result of your body thinking it lost too much weight and wants energy dense foods to get back to a weight it considers normal?
Using allulose to curb cravings. Been carnivore for about 2 years. A1C down from 7.9 to 5.1 in first year, but cravings always getting me in trouble. Lost a loved one started eating carbs again and blood sugars up and A1C up to 5.9 Trying to get back on track. Added allulose sweetened kool aid the last two months. Drink 2 cups, twice a day. Approximately 48 grams allulose each time. Has really helped get rid of cravings for carbs and feeling more satiated throughout the day. Did have some stomach upset at first, i recommend a lower amount to start and give your body time to acclimate. Took me a month to work up the dose, I started at 1/4 cup of kool aid twice a day which is 6 grams of allulose per dose. I know the dyes in kool aid are not the healthiest but they are a cheap and easy to find unsweetened drink mix.
Sounds like people who are getting off of Ozempic need to start weight training, add creatine and HMB. I guess the problem is that people that need ozempic do not want to train.
We had a large tub of lard in the pantry. It was used for making bread, pastry and cooking. Sometimes gramps would put a thick smack of lard on his bread. The whole lot of my family had their gall bladders out. They all were underground by age 72.
This is confusing to me. It sounds like Bikman is saying he doesnt like the drug because people dont change their habits and the old habits creep back in. Isnt that the problem with diets as well? You have to commit to the diet for it to work in both cases
I will never take glp1. I have ibs, gluten senstitivity, depression and anxiety and I feel good right now on Wellbutrin and I will not do anything to compromise my digestive system and therefore my mental health. My weight has been stable for a year and a half since I started Wellbutrin and I no longer binge eat. I will also never do low carb again (it would be difficult now as a vegetarian) but I’ve done low carb several times as an adult lost a crap load of weight and always ended up binge eating and gaining it all back and then some. I think the combination of focusing on getting enough protein, eliminating gluten, not consuming alcohol marijuana caffeine and most dairy, and taking Wellbutrin has been the best thing for my body and my weight. Now I am trying to focus on adding more movement and strength building to my day each day. I still weigh 220 but I’ve weighed 220 for a year and a half and that’s more than I could say for the rest of my adult life where I was either restricting food in an unhealthy way under the guise of dieting and rapidly losing weight or binge eating and rapidly gaining weight.
If you're on a GLP-1 drug, you can mitigate the lean mass loss issue somewhat.. Make sure you're getting a lot of protein, and get some resistance exercise in. Squats are good cause you can do them anywhere without equipment, and you'll need those muscles to get out of a chair as you get older.
Ben Bikman has always been so interesting to listen to. I have leant a great deal from his UA-cam channel on metabolic medicine. I am an anaesthetist who is applying for research funding to study the GIP incretin and its links to insulin regulation following major surgery. This has led me to conclude that insulin is a stress hormone secreted in response to tissue trauma. The reason why insulin functions as a stress hormone is to boost glucose delivery to leucocytes when the innate immune system is activated. This research proposal aims to investigate this hypothesis and will outline the underlying regulatory mechanisms for insulin secretion following tissue injury
Any long-term caloric deficit without adequate protein intake and strength training will result in severe muscle loss. These drugs are life savers for some people struggling to adhere to a weight loss journey. We need to thank science for that. I’m sorry Thomas, but these drugs are way more safe when used by the targeted audience than the research peptides & steroids that athletes use and abuse. We need to encourage people to maintain healthy weight and help them lose fat rather than bringing fear mongering doctors having something to sell instead
It was my understanding that if you do consistent resistance training your body prioritizes keeping your lean muscle mass and then focuses your brain gut connection to utilize your other fuel sources because your brain recognizes the deman for the muscle mass when on any simiglutide derivative. Is this not the case ?
Its unfortunate you reacted this way, but its not like that for everyone. Im 70 years old, mounjaro is a life saver for me. My skin is now amazing, my hair is better than its ever been, back to being thick and waist length like it was as a young woman, my stomach issues are GONE. I use the lowest dose, intend to micro dose later on and can only say I am now thriving. Better health wise than I was in my 40,s.
I'm just glad to hear someone with those kind of credentials acknowledging that our bodies are not just law of thermodynamics. They are complex systems influenced by countless hormones, and processes that we don't even understand yet. I hear so many people including Drs, Phds and scientists pushing the calories in calories out crap. It's just not true. Case in point ( not proof, just an observation) my husband is 6'6", 270lbs. I'm 5'2", 128. The difference in the amount of calories we eat is maybe 500-700 per day if that. Yet both of our weights are stable. Make that make sense if it's just calories.
Please tell me about a weight loss plan that doesn’t involve muscle loss when protein levels aren’t high and strength training is not utilized. I’ll wait.
@KELLYPARRISH You realize MOST of the people taking Ozempic for weight loss aren’t eating a high protein diet and lifting weights, right? It’s likely if they were doing this before, they wouldn’t need these types of drugs to begin with. Guarantee in a few years the same people who took these drugs to lose weight and didn’t change their habits gain weight back(mostly fat) and are left with less muscle mass than they had before. They are going to be in worse shape.
@@KELLYPARRISHUse your brain. He discusses the lean mass vs. fat loss. Most of the people choosing these drugs aren’t eating a high protein diet and lifting weights. If they were, they probably wouldn’t need the drug in the first place. The problem lies when they get off the drug, they are left with way less muscle and once their hunger comes back, they will more than likely gain fat back quickly. A higher body fat percentage will leave them worse off than before, and the cycle continues.
@ - same as any other diet. Protein and strength training are not negotiable. I’d have no problem taking a small dose of this for the rest of my life, much like one would do for insulin, or blood pressure medication. They are a miracle for the right people.
@@KELLYPARRISH There are side effects, some serious. Why be a slave to big pharma for the rest of your life?! You realize most people can’t afford that correct?
It’s hard to understand how it couldn’t be calories in / calories out. We may not be a steam engine, but we do use energy and food provides energy so there has to be an energy balance.
Because they make more money if people need to follow them instead of taking a medication that makes weight loss and a healthy lifestyle way easier. No offense to them, it’s important to hear many sides of a new invention.
That's interesting how Bikmen explained Glucagon and diabetes 1 issues, but I'm kinda confused, let's talk about keto- and in particular carnivore guys, don't they often claim that their diabetes issues reduced or vanished after going keto/carnivore, their insulin and glucose problems went to normal levels? By eating more protein and no carbs you produce more glucagon than insulin, it's needed because you don't have glucose in your blood due to low or no carb intake and start to burn protein and fat for fuel ---> ketosis. So according to Bikman's explanation, do keto and in particular carnivore-people endanger themselves for diabetes in the long run, because they produce more glucagon due to their diet, meat meat meat?
Gluconeogenesis will occur more because it has to as you said but only to the point you have enough glucose so your total level will be correct and much lower compared to also eating too many carbs. However, if people eat a tonne of protein then yes that excess can also result in a glucose excess but that's extremely difficult to do eating a clean diet as you just get full.
Eating strictly meat makes my blood glucose spike ridiculous levels. Eggs and shrimp seem to be the only ones that don't spike it so much. That I have found.
@@Szilvia_Szilvia That is the only type I do eat. I don't care at all for the irony taste of lean meats. I will eat venison, but it is difficult tp deal with the irony taste sometimes.
Main point here. ALL dieting and fat loss with or without glp’s WILL PRODUCE THE SAME lean mass loss and weight gain upon returning to former habits. It’s NOT the Ozempic. Vegan diet has an even worse long term outcome with muscle, bone loss, nutritional deficiencies and people aren’t vilifying that choice.
Sounds right. The body has mechanisms to balance out any drug taken over a long period. My policy is to avoid taking any drug or supplement that is not food for a long time. Food has benefits that cannot be duplicated by drugs, but it has to be real food.
Maybe i am an outlier but Ozempic helped me put my habits in place, used for 3 months to lose 8kg and stopped it because of $$$, for 5 months after i am down 16kg and in a healthy weight.
🇨🇳🇨🇳🇨🇳 😉
I think this is a perfect example of how the drugs could be effective
That’s almost illogical.. unless you are doing something dramatic to keep the weight off…
enjoy the long term consequences bud
Ok but did you learn anything. Did you learn hoir macro nutrients, your maintenance phase or your meal timing. I highly doubt it. It's easy to lose, it's harder to keep it off. Learn of to keep it off or it will come back.
Thank you Thomas, for sitting there SOOOOO patiently, allowing this brilliant man to speak at length, with the freedom to veer off track, in order to further explain complicated, but important, aspects. YOU have my sincerest respect. This is why I subscribe to you! You are as interested in learning, as your audience, not just in hearing yourself speak.
THANK YOU!!!
I
100% ❤
Thomas is an Excellent interviewer allowing his brilliant guests to speak 🗣️ ❤
I’m a physician. This doc is fantastic at explaining this. One of these best explanations regarding this topic I’ve heard.
He's not a doctor. He is a researcher and a professor. He knows his stuff. Doctors are no researchers and should not comment on nutrition.
Too bad much of his information is inaccurate
@@alleyinn1how so? would you give some examples? genuinely curious
@@alleyinn1 Please provide the accurate information.
@@newswatcher-rf2up Chances are you will only get a "Google it. It's there." 🤦♂
Resistance training plus adequate protein alleviates the lean tissue loss. ANYONE, regardless of the modality, will lose lean tissue if weight loss occurs absent adequate protein and resistance training. I monitor my patients closely on GLP 1 RA's and our main topic at visits is: how much protein are you eating? How much exercise are you doing? These are people with diabetes, not for weight loss. It can be profoundly beneficial in that population. Don't let the misuse for weight loss purposes overshadow why this class of drugs was developed: type 2 diabetes.
While I have to thank you for mitigating some of the harm that these drugs can cause, it's a bit eye-brow raising to make a comment about how normal weight loss is with this drug when most of video is about how it is anything but normal. Dr. Bikman raises quite a number of issues with the dosing (which is different from what's used for diabetes management), mechanism of action, patient initiated drop out rates, what happens in a reasonablly short time frame after quitting, and a few other topics. The doctor speaks with more clarity and brevity than I've seen yet on this topic and he even makes some concessions and admits when it's not all bad. I'm sure you're extraordinarily busy with your practice but when someone raises some fair points I think it's worth acknowledging that.
So your patients are going to stay on them forever?
Does eating protein prevent bone loss?
The problem is that misuse IS overshadowing their use responsibly. Loads of influencers, media, etc frame GLPs as a long term weight management drug. And obviously the manufacturers want as many people as possible taking them for as long as possible so they aren't going to step in and tell people to stop being irresponsible.
I agree they're great initially for someone with diabetes to get it under control faster and whilst they learn to eat a no carb diet. But that person resolving their health through diet and not needing these drugs should be the long term goal.
@@TG-vg3qeI think the studies show that it’s the resistance training not protein. You stress the bones with weight training and that forces the bones to stay stronger in order to address that stress.
31:16 Before I ordered a pricey Caesar salad in a restaurant last month I asked the server to find out if it was JUST olive oil in the dressing (which is the only oil it should have), because, I told her, I'm allergic to Seed oils. She returned 10 minutes later - "Sorry Ma'am... it's got canola oil in it." EVERYTHING now has cheap seed oils in it. The best fish and chips I ever had were back in the 60s in San Francisco - all cooked in tallow.
That’s why I don’t eat out. You don’t know what you’re getting. Seed oils are so bad for you!
@@tinadehart3526 , if you must eat out, take some Vit. E to counter seed oils.
@@tinadehart3526I agree and not only is seed oil bad for human consumption this Mo crop is damaging our natural environment.
You literally don't need oils in cooking. Being a vegan super easy to avoid. The water in veggies prevents them sticking
They key takeaway I got from this is, eating seed oils causes peroxidation. Peroxidation is damaging, and encourages fat cells to grow, and the type of fat that grows encourages insulin resistance. Insulin reistance will increase your appetite, because your cells are resisting the delivery of energy. So in turn you end up eating more of the seed oils creating a self perpetuating cycle of weight gain and poor health. The only way out is to remove Ultra processed food, avoid seed oils, lose the fat that is encouraging insulin resistance and fat storage.
I haven't eaten any seed oils and kept my PUFA intake extremely low for the past 3 years. I still am overweight and have insulin resistance. For me it's the carbs keeping me this way. Granted I am not obese, just overweight but with very high fasting insulin.
@@Lopsa192 To lose weight you need to be on a low inflammation. Say seed oils are 50% and carbs are 50%. If you remove seed oils you are still 50% inflamed so can't lose weight. If you remove carbs and seed oils youll be at 0% and can now lose weight. If you remove carbs but eat seed oils "dirty keto" you can still lose weight but it will be slower.
Is CLA in that category??
Only thermally oxydized seed oils cause peroxidation. And oxydation occurs only with repeated heated so seed oils outside of some UPFs are not dangerous
@@vaevictis2789 So the deep fryers at fast food restaurants where they keep reusing vegetable oil or peanut oil all day is more dangerous than just using a little splash of fresh seed oil at home?
I’ll ALWAY tune in to Dr. Bikman’s talks! Thanks Thomas! 😊
Dr. B is the best🎉 Thank you for having him on!
Love Dr Bikman. Been an athlete my whole life and always ate pretty heathy BUT struggled with weight and always had a huge appetite and barely had a satiety signal. These GLP-1 helped where diet lifting weights, running and starving myself could not budge the scale. People need to be educated that lifting weights is a non negotiable on a GLP-1 and most people will need to stay on a GLP-1 to some degree long term to maintain a healthy weight. 🙌I’m 53 5’1” and I lost 50lb and gained lean muscle and strength using GLP-1. Hardly had a negative side effect. Maintaining well over a year at 113lb. Helped me to improve insulin sensitivity manage appetite and satiety. Have done 2 DEXA scans confirming muscle gain, 10%Body Fat. Exclusively work out at home. Sharing my weight loss & fitness journey on my UA-cam channel💪
Yes girl! You did it right! Listened.to your body. Got the help you need AND did and continue to do the work.
@@gretchentoddyludwick9476thanks so much 💕
You are the exception.
Aew you still on if?
@@theoneandonly1158I think we all have the potential if we have the desire to learn and apply what we learn. This is the whole reason for my YT. Is to help empower other people with the right knowledge you too can get healthy lean and strong AF
Good explanations but what you are NOT saying is that these same issues occur for almost anyone that goes on a low calorie diet with out exercising, and the majority of people who lose weight do gain it back because they didn't change their eating habits. Stop the scare tactics about this particular compound. Also - you mention that 70% of people voluntarily get off the compound - how many of those were because they could not afford to stay on the shot.
The difference is that those of us who lose it naturally actually learn something in the process, and develop self discipline. Verses people who inject to erase appetite and cravings. Sorry but no, the failure rate in terms of regain is going to be higher in the people who didn't do it naturally. It's all about actually working for it. You don't just casually undo all that actual hard work. Speaking from experience
@@heythere5817 Nonsense. If that’s the case why do 85% of people who lose weight (regardless of how they do it) gain it all back? The statistics don’t lie.
@@heythere5817 up to 95% of people who lose weight with diet and exercise will gain back all the weight within 5 years. So it's not unique that GLP-1s also fall in this category.
Many like me went off voluntarily.
Not for the cost, I'm Italian and registered as diabetic so I get it for free.
It's the side effects that scare many people...and having turned Carnivore helped me not needing this crap anymore 😅
I agree here - strongly. If „facts“ are stated like the rate of people who stopped the drug, what were the reasons? And how many cases have been reported where patients received a low dose of the drug? Misuse or abuse of any drug will increase the side effects. Nothing new here. So maybe doctors could me more educated on how to dose the drug actually.
Ben Bikman makes so much sense. I could listen to him all day!! What a great teacher!
As a type 1 diebetic who also got type 2 over the years, I can say glp1's helped my diabetes by a bunch. I had so much insulin resistance, I was taking over 150 units a day. No matter how much I worked out or dieted I could never lose weight, I would still gain weight. Now I take 1/3 of that insulin and no longer need blood pressure meds just after 4 months. Also down 40 lbs. The key is to not titrate up too fast on the dose and change shot locations.
I've only known type I diabetics who took their health very seriously and watched everything that they ate except on girl who unfortunately had a mother who baked a lot. She lost her eyesight in her 20's.
I’m 52, went on Ozempic, lost 10kgs and got my blood sugar in normal range. Stalled. Have 10 more kilograms to go so have stopped Ozempic and switched to keto and transitioning to carnivore. Just as good to control hunger and cravings with no nausea etc. I train with weights and prioritize protein (since I was 18) so no muscle loss
Thats Awesome!
At 51, I started following Thomas for a year and a half now. Down 100lbs. I went from 353lbs to 253lbs. I was a prediabetic mess with a diagnosis of psoriatic arthritis. I didnt feel like doing anything! Now I do resistance training, lots of walking. Usually I eat keto or ketovore. I have stalled at 250lbs. Occasionally, I might drop down to 248 or so, but I can never seem to maintain it.
I just keep telling myself that I have made a change in diet and lifestyle, and it is where I feel the best. It doesn't matter how long it takes.
Wish you the best! 😊
@@RLeeErmy Well done. 👏🏼Yeah stalls happen and it might be worth getting another perspective to help you solve it. I’m joining Kelly at My Zero Carb Life for the month of November to help me step it up. It’s just $50 for the month. Perhaps consider joining?
I’m 49 worked out 5 days a week and was 226. Achieve 175 at one point eating fairly good. Lost my way and sit to 230. My point is I ate better whole foods. Lost 39 lbs which I had lost in 3-4 yr period. My point it is when I started eating better cutting process food and process sugar I had better weight loss. I’m healthy now the. I was at 175 lbs and had so much muscle. The best point is eat better not using these drugs. My am still in my journey. I’m set to lose max 15 lbs. i’m 190 lbs from 228. I’m able to play tennis with my kid better than when i was prior at 175lbs. So the key is diet or in other words eating better. If drugs work for you they should be only temporary used with caution.
what the hell is a kg?
@ tell me you are American without telling me you are American 😁
I LOVE how Thomas lets this man speak.
No interruptions.
Brilliant explanation of how these drugs work.
Am on GLP1 with instructions to lift weights, eat protein, review emotional management..so benefits are to get weight normal, sleep, come off pain meds and reduce all risk mortality....Expecting to come off it in 6 months. .also expecting it to be as difficult as it was before to keep the weight off....story of my life....but my body has been fighting weight loss due to menopause and my physiology...
My cravings have disappeared and I don't feel sick at all 😊
These drugs need to come with instructions to change/improve habits
Agree. I have the same experience. Food noise almost gone and I do not feel sick. Not to mention the pain in my body is gone and there are other significant benefits too. Not everything said in the first 11 min of this video is on point. I rarely comment on a UA-cam video. Let's not keep the obese people down. There is clearly a problem that the health & fitness industry is not able to fix. It has continued to get worse for decades.
As a cell scientist working in conjunction with other professionals around this issue, for obesity please, please someone spend some time looking at ‘why’. As soon as it comes back to ‘learning to eat differently’, ‘discipline’ etc. the boat has been missed. When it comes to life long struggles with significant weight control, this is an early developed trauma response where something neurological has gone off the rails. Until there is a focus on how to manage that, there will continue to be more decades of effort down the wrong path.
Hi, I am a neuroscientist that is also looking into the potential effects of neurological/psychiatric disorders on obesity. What you mentioned is quite interesting, do you have reference journal articles for it?
Ive just started it. My parents died in their 60s of stroke/heart attack. Ive been the same 4.5 stone overweight all my adult life, im 60 now. Mounjaro has given me wright loss and at lady, my mind is not at war constantly battling not to eat.
Ive upped protein levels, added in resistance training.
Yes i worry about stopping Mounjaro, but failure rate is 70% versus 95% for traditional diets. Its better odds.
I felt so horrible on Ozempic, aside from the atrocious cost (even here in Canada), at the lowest dose in the pens I felt bloated and nauseous all the time, like 5 bites of dinner and I was done. Not because I wasn't hungry, I was in extreme discomfort. I was getting so depressed, I had to quit. It took months before my digestive system felt normal again. I can eat my entire meal and not feel like crying. Yes I have diabetes and I need better control, but if I feel more horrible on the drug what's the point? No thanks.
I had a gastric bypass 25 years ago. I was not diabetic. I immediately lost what I will call food craving but basically I just felt like I had a normal appetite. It wasn't that I couldn't eat because I was too full, I never felt like overeating. I kept telling everyone who would listen, this is what normal people feel like. No one, including my doctor, seemed even slightly interested. I'm glad you have found the science behind it.
Protein and weight training - non negotiable on this drug.
Protein and weight training is the correct drug.
I thank God that I remain healthy after all the crazy things I did to my body over the last several decades to be thin... and I am typing this to share that the best, most effective way I have learned to lose weight was to buy a little notebook and *_HONESTLY_* keep a daily calorie counting journal of everything I put in my mouth and targeting a calorie intake slightly lower than my output. By acknowledging and managing my calories by balancing my nutrition to nourish and *_fuel_* my body's needs and appetites, I lost 25lbs slowly and forced myself to confront my eating impulses and manage my health with better choices.
My parents lived in Belgium in the 80’s and you could find frite (French fry) stands in the countryside where they made fries in farm stands with animal fat. They served them with mayonnaise that they made fresh themselves. They had something called ‘sauce americaine’ that was ketchup like. It was the first time I ever liked mayo in my life. Those fries were the very best in the world.
Yes, yes. I was born in Belgium, and I remember the frite stands too. My parents made them at home as well, with the homemade mayonnaise. The best.
I used it for one month but had 5 major side effects and then discontinued. However, coupled with the change to a keto like diet it did enable me to make the transition without the torture of continual hunger pangs. So now 40 lbs lost in 4 months and blood work is fine - down from 7.9 A1C to 5.6 in 3 months.
Ok but did you learn anything. Did you learn hoir macro nutrients, your maintenance phase or your meal timing. I highly doubt it. It's easy to lose, it's harder to keep it off. Learn of to keep it off or it will come back.
@@theoneandonly1158 actually 100's of hours researching nutritional and medical studies. The original post does not lead to your conclusion
@@theoneandonly1158if you are on a carnivore diet you don’t need to track anything. You’ll never gain weight on a carnivore diet.
The same could be said with weight loss by any means. It’s always easy to take it off yet very difficult to maintain. Whether you’re taking a med or not you have to do the inner work and get your body used to, and in love with, movement. The meds can help some people get started.
As a 75 yo type 2 diabetic stopped using Ozampic, much improved quality of life. Low carbohydrate diet and low insulin dose high protein/fat and vegetables with 120 km a week on the bicycle losing weight good blood sugar.
66 yr old here and the muscle loss was devastating. No one told me how to take it or what to expect. Fighting to get back what I lost.
GLP med keeps me on a steady carnivore path and is changing my life. I’ve lost 120 pounds so far. The amount of lean mass lost is equal to weight loss surgery, and no one complains about that. Easy solution…Lift weights.
Thank You for having Dr Bikman on.
So good to see a host who is quiet while the guest is speaking, paying attention and taking notes for the following questions instead of being the whole time just interrupting with useless "yeah... Sure... Of course..."
I can hear Mr Bikmam's talks and interviews again and again 👍
Love Dr. Bikman! 🙌
Thomas, I always appreciate your thorough approaches to research and information. I declined a college education to pursue personal goals. I dont endorse this plan for others but for me, it was good. I committed to being self taught. People like yourself have made the journey very fulfilling. Keep up the good work. You are helping many of us. Im 61 and in the best mental and physical health of my life. Kudos
If you live in the state of Utah and want a great french fry; Go to Redmond Farms in Orem and get their coconut fries. If you own a fast food place, please consider going to beef tallow or coconut oil. Charge a slight premium and help our country get healthy (er).
Er indeed hehe.
Thanks for the heads up! Was just looking at purchasing a quarter of a cow from them. I had no clue they also sold french fries.
Potatoes are not good, no matter what you fry these in 😢
@@DebbieTDPfor many people nightshades cause horrid joint pain too. I have avoided veggies for years because of the plant toxins.
and butter!
I never get tired of listening to Dr Beckman !! Soooo much information. I know several people who were on ozanpic stopped it , did not change their eating habits n gained it all back n more when stopped taking.
Well obviously if they eat the same they will weigh the same
I think the satiation or resolution of "food noise" isn't just due to chronic nausea.
It’s not just nausea . Dr Tyna Moore explains. Glp’s act on addiction centers in the brain muting the reward impulse from food and other addictions.
@NorthlandSLC agreed
In my experience the gut noises are linked to hidden gluten!! 😮
I have used tirzepatide last year for ~4 months and lost in total 70 lbs, BMI now at 21. (not all due to Tirzepatide (maybe half of it)). It has been 1.5 years, and I am still maintaining my weight. If you use GLP-1 drug to help you getting to your goal and at the same time change your diet, is this not what we want? I chose to stop the injections because I was where I wanted to be not because I was feeling sick. Note that I kept my dosage at
20 units isn’t a dosage, just a measure of how much liquid you’re injecting yourself with. How many mgs per week of the drug were you using?
Tirzepatide was expensive but worked great. I was 170, got down to 130 and six months I’m back up to 145 and steady.
I started questioning everything, especially government health advice! After reading "Health and Beauty Mastery" by Julian Bannett, I completely changed my habits. This book reveals so many shocking truths about the health industry!
Thanks for sharing
The health industry has been lying to us for decades!
These bots/paid ad comments are getting crazy...
Bottom line…ozempic and wegovy isn’t for older people. Younger people should use as a last resort.
Why not make all those boring front lawns in a America into vegetable patches to feed yourselfs?!😊
Ben is the best!
The opening Ad for this video was an Ozempic commercial.
I’ve learned so much from reading Dr. Bikman’s book, How Not To Get Sick, but I have to disagree with what he says at 11:03. My food noise, aka cravings went away and it wasn’t because I felt sick or nauseous. I’ve been on Zepbound for 8 months and I’m still on a low dose (5mg- the second dose on the titration schedule). I’ve lost 65lbs, improved my a1c, eat 100-130g of protein daily and loose about 1- 1 1/2 lbs a week. I agree that some on this medication are on doses that have completely destroyed their appetite and cause GI issues, but in most cases the problem isn’t the medication itself, it’s the dosing schedule. Many of us are using this as a tool in combination with lifestyle changes. Starting this medication has been the best thing I’ve done for my health. Just my 2¢ 😊
Same!! I’m only 6 weeks in on a very low dose and it has felt life changing.
@ that’s awesome!! I wish people knew that it doesn’t have to make you sick if you go up in dose slowly. Good luck to you!
I watched the entire length of the video but couldn't find any revelations that haven't been known since these drugs launched like a decade ago. Yes, you regain weight after stopping these drugs IF you havent used them to modify your behaviour and changing eating habits, you lose muscle mass on any weight loss program IF you arent strength training and increasing protein intake. I took GLP-1/GIP for 18 months at the max dose and then tapered down to a maintainence dose of 2.5 mg over the next 6 months and am still losing some weight BECAUSE I was able to fix my lifestyle and start strength training. There is no "unpopular" truth in this video, all well known things that happpen and the things that your doctors will discuss with you before you go on these medications (if they arent change your doctor). I am sper excited about Retatrutide and Mazdutide which will be coming to market over the next 24 months and be even more effective.
Oh yes guinea pig, go on taking drugs!!
Change your diet and you won't need chemicals
@Ronibearable I think you are confusing dosage for ozempic, I am on tirzepatide and the lowest dose for it is 2.5mg both for diabetes and weight management, also I take one shot of the lowest dose every 2 weeks and it has been excellent for my blood pressure, glucose control, weight management and also been sober for 3 months now - I love tirzepatide although do plan on going off it in about an year.
@@Ronibearable I did mention glp1/gip but all good, the important thing is that the medications are working for us and every doctor worth their salt will curate a personalized plan for their patients on these drugs and these are safe for long term use and maintainence and alarmists like Bikman need to realize the harm they are doing by overstating the negatives to push their metabolic programs ( I believe he is on the board of levels and another similar program)
@@Ronibearable- you really need to educate yourself. Different GLP1’s have different concentrations.
I occasionally make French fries for my sons. I start with potatoes, fried in tallow, I rendered, and sprinkle with sea salt. They wondered why they had never tasted anything like this before. Only way they eat French fries now.
Take a shot of Ozempic each time he says great question
I died
@@druidiron😂😂😂😂😂😂
"it's the nice way of saying I feel sick to my stomach all the time" -- this is absolutely 100% correct and exactly my experience. I was only on it for a month and a half. It was a very nice tool to release the grip of food addiction but boy did it make me feel bad.
I'm on Wegovy for 5 weeks now and haven't experienced a single side effect. It's stopped my cravings for food and I don't overeat anymore. I've moved from 0.25mg now to 0.5mg per week, but I'm not going to titrate the dose up any further as it's doing its job nicely at these low levels.
For me, losing weight is easier than keeping it off. Down over 100 lbs. from 11 years ago. BMI this morning was 22.7. Time for the daily mile and half walk.
The key is learning to keep it off. It takes even more work to do that.
My friend is diabetic. She's been prescribed Ozempic. She struggles to get the meds because the high demand. Some of the pharmacists require her doctor to call them to explain the necessity of the drug for her before they will prescribe it. She has gone weeks without her medication because they are out, or they have additional hoops to jump through. Of course, they don't tell you the additional hoops until you call wondering why it's taking so long to fill the prescription you've had for months.
He almost touched on an important point, but then missed it: the GLP-1 stimulus from meds like ozempic is not comparable to endogenous levels. Discussing what foods have what impact on GLP-1 is completely misleading because no foods increase GLP-1 anywhere near what you get from the pharmacotherapy. Translation: foods that “increase glp-1” are not Ozempic substitutes and they don’t induce weight loss. Like he even pointed out earlier in the conversation, even lower doses of ozempic don’t induce much weight loss, and those low doses are still orders of magnitude higher than you will ever get from a steak dinner. What we discovered is that there is an effect of GLP-1 that emerges at concentrations much higher than you would ever encounter naturally. That’s why these medications work and diets don’t.
Diets do work. I lost 40 kg on keto and Carnivore 😅
Btw those medications are a diet, I felt so full and bloated...😢
@ as an intervention, diets have a terrible track record. Modest weight loss that isn’t sustainable. Do you know how few people can maintain a carnivore or keto diet long term? Very few.
Wegovy is the same
Curious to learn more about Allulose and its impact on GLP-1.
I’ve been on Wegovy for 6 months and I’m not burping or have bad breath. And, I’ve lost 25 pounds.
20:36 I'm of an advanced enough age to remember over the counter diet pills. Essentially it was speed. What they did was curb your appetite, quite effectively! And while they were eventually withdrawn from sale/use, I don't recall the side effects being anywhere near the laundry list associated with GLP1 drugs. Learning to eat a proper human diet, devoid of or tightly restricting carbs, is the natural, non side effect means to health, including weight loss.
You are talking about ephedra. I was wonderful.
@ I think it was branded Dexatrim but seriously that stuff made you mental
Thank you for this. Love hearing such an excellent scientist explaining things so simply. I bet he is a fantastic supervisor for his students.
the best explanation ever !Thanks Dr. Bikman
I tend to believe a doctor/researcher more when he is in shape himself. Bikman fills that requirement.
Informative and helpful chat.
Starts at 5:21
THIS is the guy that should be the head of the FDA! I love Ben!
As a pharmacist who uses these medications, his characterization that it reduces appetite because it makes you feel a little sick is just flat wrong. And that fear almost kept me from trying this life-changing medication. In reality it just makes you think about food less, it reduces food noise and appetite, and it makes you feel satisfied sooner. It works exactly how you would hope a weight loss medication would work. Some people experience nausea. But don’t confuse the side effect and the actual pharmacological action. They are categorically different and the one doesn’t follow from the other. I rarely have any nausea, but my appetite is clearly diminished despite no nausea.
My husband never had the nausea. But 2 weeks ago he had to be rushed to the hospital because of gastroperisus(don't know how to spell that). Surgeon told him it was caused by the ozempic! Scary!
I’d also add taking too high of a dosage effects how you feel. Plenty of people actually add muscle while on these medications.
In addition, ANY weight loss (medicated or not) can lead to muscle loss if you’re not eating appropriately and lifting heavy enough weights that trigger your muscles to maintain.
I think Dr. Bikman is great and I’ve listened to him for a few years now. He makes learning about insulin and all that goes with it, easy…. but I will completely disagree with him on this.
It slows down the gastric emptying, if you feel full you don't think about food. But I felt bloated all the time.
Semaglutide delays gastric emptying and may affect the rate of absorption of concomitant oral medications. Semaglutide should be used with caution in patients receiving oral medications that require rapid gastrointestinal absorption.
@@dlyose
Semaglutide delays gastric emptying and may affect the rate of absorption of concomitant oral medications. Semaglutide should be used with caution in patients receiving oral medications that require rapid gastrointestinal absorption.
@@DebbieTDP
My husband almost died from Ozempic. It paralyzed his stomach and intestines.
In Australia these drugs are prescription only and only for diabetic patients🇦🇺
There. Is. No. Shortcut.
Good stuff! Thank you for sharing
My husband is on Ozempic , a little over a year now. Some of the side effects have subsided, nausea still from time to time. He’s lost a lot of muscle and he craves sugar, he eats way more sugar than protein and tired a lot
Ugh me too. Off 9 months. I still have major anxiety and my sugar cravings are way higher than they ever were. I recently started carnivore but so far the sugar cravings are still crazy. Oh and I’ve been off it 9 months. It’s not worth it!
Please, please, please try and get him to eat a cooked breakfast with plenty of meat, eggs and maybe tomatoes, mushrooms etc (or similar). It will help stave off his hunger and cravings. Then, slowly add in more protein and less carbs to each meal. I find it's better to slowly adjust your body and change your gut biome so that your body stops craving the wrong stuff. I hope you don't mind my suggestion.
Outstanding, thank you!
Regarding the return of sweet cravings returning to pre drug levels, couldn’t that be independent of the drug? I.E. a result of your body thinking it lost too much weight and wants energy dense foods to get back to a weight it considers normal?
Using allulose to curb cravings. Been carnivore for about 2 years. A1C down from 7.9 to 5.1 in first year, but cravings always getting me in trouble. Lost a loved one started eating carbs again and blood sugars up and A1C up to 5.9 Trying to get back on track. Added allulose sweetened kool aid the last two months. Drink 2 cups, twice a day. Approximately 48 grams allulose each time. Has really helped get rid of cravings for carbs and feeling more satiated throughout the day. Did have some stomach upset at first, i recommend a lower amount to start and give your body time to acclimate. Took me a month to work up the dose, I started at 1/4 cup of kool aid twice a day which is 6 grams of allulose per dose. I know the dyes in kool aid are not the healthiest but they are a cheap and easy to find unsweetened drink mix.
Then by definition you are not carnivore.
@@tinadehart3526so many carnivore snobs on here.
Sounds like people who are getting off of Ozempic need to start weight training, add creatine and HMB. I guess the problem is that people that need ozempic do not want to train.
We had a large tub of lard in the pantry. It was used for making bread, pastry and cooking. Sometimes gramps would put a thick smack of lard on his bread. The whole lot of my family had their gall bladders out. They all were underground by age 72.
Never have your gallbladder removed. You won’t be able to process any fat.
@@tinadehart3526 i had to. Stones the size of peas and major colic :(
Look at the more recent data. Lard didn't cause the problem.
This is confusing to me. It sounds like Bikman is saying he doesnt like the drug because people dont change their habits and the old habits creep back in. Isnt that the problem with diets as well? You have to commit to the diet for it to work in both cases
I will never take glp1. I have ibs, gluten senstitivity, depression and anxiety and I feel good right now on Wellbutrin and I will not do anything to compromise my digestive system and therefore my mental health. My weight has been stable for a year and a half since I started Wellbutrin and I no longer binge eat. I will also never do low carb again (it would be difficult now as a vegetarian) but I’ve done low carb several times as an adult lost a crap load of weight and always ended up binge eating and gaining it all back and then some. I think the combination of focusing on getting enough protein, eliminating gluten, not consuming alcohol marijuana caffeine and most dairy, and taking Wellbutrin has been the best thing for my body and my weight. Now I am trying to focus on adding more movement and strength building to my day each day. I still weigh 220 but I’ve weighed 220 for a year and a half and that’s more than I could say for the rest of my adult life where I was either restricting food in an unhealthy way under the guise of dieting and rapidly losing weight or binge eating and rapidly gaining weight.
I'm a huge fan of both of you! 🎉 Excellent content!
I think this interview was much needed!
Period
Thomas, I so appreciate you, your videos, & your hard work!
If you're on a GLP-1 drug, you can mitigate the lean mass loss issue somewhat.. Make sure you're getting a lot of protein, and get some resistance
exercise in. Squats are good cause you can do them anywhere without equipment, and you'll need those muscles to get out of a chair as you get older.
Great explanation on a complex topic. Great interview.
Excellent explanation. I learned so much.
Ben Bikman has always been so interesting to listen to. I have leant a great deal from his UA-cam channel on metabolic medicine.
I am an anaesthetist who is applying for research funding to study the GIP incretin and its links to insulin regulation following major surgery.
This has led me to conclude that insulin is a stress hormone secreted in response to tissue trauma. The reason why insulin functions as a stress hormone is to boost glucose delivery to leucocytes when the innate immune system is activated.
This research proposal aims to investigate this hypothesis and will outline the underlying regulatory mechanisms for insulin secretion following tissue injury
DR BIKMAN!!!! I LOVE that you have him on!!! Yay!
As always, if it's too good to be true, do your research. This is a good podcast to start with. Brilliant. Thank you.
Hi,
Dr. Bikman is freaking interesting (you too Thomas of course)
Any long-term caloric deficit without adequate protein intake and strength training will result in severe muscle loss. These drugs are life savers for some people struggling to adhere to a weight loss journey. We need to thank science for that. I’m sorry Thomas, but these drugs are way more safe when used by the targeted audience than the research peptides & steroids that athletes use and abuse. We need to encourage people to maintain healthy weight and help them lose fat rather than bringing fear mongering doctors having something to sell instead
For balance, check out dr tyna moore. It’s key to not use glp-1 as a (i.e. combine with diet and strength training) and to use the lowest dose poss.
It was my understanding that if you do consistent resistance training your body prioritizes keeping your lean muscle mass and then focuses your brain gut connection to utilize your other fuel sources because your brain recognizes the deman for the muscle mass when on any simiglutide derivative. Is this not the case ?
It is as far as I'm aware. The main problem is that is just stimulus. People on GLPs risk not eating enough protein.
@@paulc5389 or any other essential nutrients for that matter...
@@paulc5389protein is easy to track. People should still have appetite on glp-1. The issue is doses being too high.
Thank you!
Outstanding guest!
Excellent instruction….thank you both.
Fascinating and really instructive. Thanks!
I got off, looked 15 years older and now back at where i started. 61 years old. It's not good to take that stuff, the Ozempic face is real
Its unfortunate you reacted this way, but its not like that for everyone. Im 70 years old, mounjaro is a life saver for me. My skin is now amazing, my hair is better than its ever been, back to being thick and waist length like it was as a young woman, my stomach issues are GONE. I use the lowest dose, intend to micro dose later on and can only say I am now thriving. Better health wise than I was in my 40,s.
I'm just glad to hear someone with those kind of credentials acknowledging that our bodies are not just law of thermodynamics. They are complex systems influenced by countless hormones, and processes that we don't even understand yet. I hear so many people including Drs, Phds and scientists pushing the calories in calories out crap. It's just not true. Case in point ( not proof, just an observation) my husband is 6'6", 270lbs. I'm 5'2", 128. The difference in the amount of calories we eat is maybe 500-700 per day if that. Yet both of our weights are stable. Make that make sense if it's just calories.
It is disingenuous to attribute the lowered appetite to nausea. There is a definite reduction completely independent of any GI side effects
Thanks for this. People lose more fat free mass rather than fat. However what if they work out and strength train - does the muscle mass stay?
Same as any other weight loss plan.
The muscle loss should be the reason most people avoid these drugs. As the saying goes, “ If it sounds too good to be true, it probably is”
Please tell me about a weight loss plan that doesn’t involve muscle loss when protein levels aren’t high and strength training is not utilized. I’ll wait.
@KELLYPARRISH You realize MOST of the people taking Ozempic for weight loss aren’t eating a high protein diet and lifting weights, right? It’s likely if they were doing this before, they wouldn’t need these types of drugs to begin with. Guarantee in a few years the same people who took these drugs to lose weight and didn’t change their habits gain weight back(mostly fat) and are left with less muscle mass than they had before. They are going to be in worse shape.
@@KELLYPARRISHUse your brain. He discusses the lean mass vs. fat loss. Most of the people choosing these drugs aren’t eating a high protein diet and lifting weights. If they were, they probably wouldn’t need the drug in the first place. The problem lies when they get off the drug, they are left with way less muscle and once their hunger comes back, they will more than likely gain fat back quickly. A higher body fat percentage will leave them worse off than before, and the cycle continues.
@ - same as any other diet. Protein and strength training are not negotiable. I’d have no problem taking a small dose of this for the rest of my life, much like one would do for insulin, or blood pressure medication. They are a miracle for the right people.
@@KELLYPARRISH There are side effects, some serious. Why be a slave to big pharma for the rest of your life?! You realize most people can’t afford that correct?
I have a friend who came off and she gained it back super quick. I wonder the long term affects.
This is the scientist that Dr. Layne Norton obliterated for his takes on fat cell sizes. He refused to debate Dr. Norton. So hard pass.
It’s hard to understand how it couldn’t be calories in / calories out. We may not be a steam engine, but we do use energy and food provides energy so there has to be an energy balance.
Calories have nothing to do with weight. Do some research.
@ that doesn’t make logical sense because if it were true there wouldn’t be famines.
Why are these drs not mentioning lifestyle changes with these drugs?
Because they make more money if people need to follow them instead of taking a medication that makes weight loss and a healthy lifestyle way easier. No offense to them, it’s important to hear many sides of a new invention.
Jiffy still makes their corn muffin mix with Lard!! Carbs yes but at least no seed oil. Lol
That's interesting how Bikmen explained Glucagon and diabetes 1 issues, but I'm kinda confused, let's talk about keto- and in particular carnivore guys, don't they often claim that their diabetes issues reduced or vanished after going keto/carnivore, their insulin and glucose problems went to normal levels? By eating more protein and no carbs you produce more glucagon than insulin, it's needed because you don't have glucose in your blood due to low or no carb intake and start to burn protein and fat for fuel ---> ketosis. So according to Bikman's explanation, do keto and in particular carnivore-people endanger themselves for diabetes in the long run, because they produce more glucagon due to their diet, meat meat meat?
Gluconeogenesis will occur more because it has to as you said but only to the point you have enough glucose so your total level will be correct and much lower compared to also eating too many carbs. However, if people eat a tonne of protein then yes that excess can also result in a glucose excess but that's extremely difficult to do eating a clean diet as you just get full.
Eating strictly meat makes my blood glucose spike ridiculous levels. Eggs and shrimp seem to be the only ones that don't spike it so much. That I have found.
@@frankenz66 eat muscle meat of large ruminant animals together with the associated fat. Carnivore is NOT about eating lean meat in itself.
@@Szilvia_Szilvia That is the only type I do eat. I don't care at all for the irony taste of lean meats. I will eat venison, but it is difficult tp deal with the irony taste sometimes.
Main point here. ALL dieting and fat loss with or without glp’s WILL PRODUCE THE SAME lean mass loss and weight gain upon returning to former habits. It’s NOT the Ozempic. Vegan diet has an even worse long term outcome with muscle, bone loss, nutritional deficiencies and people aren’t vilifying that choice.
Preach
Sounds right. The body has mechanisms to balance out any drug taken over a long period. My policy is to avoid taking any drug or supplement that is not food for a long time. Food has benefits that cannot be duplicated by drugs, but it has to be real food.