How Does Low-Dose Aspirin Work?
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- Опубліковано 30 вер 2024
- You ever see those commercials suggesting people take a tiny dose of aspirin every day? It’s an amount so small it doesn’t really work for pain relief, yet taking low-dose aspirin is fairly common, among those at risk for heart attacks or stroke. Here’s why aspirin works in a baby-sized dose.
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Producer: Kirk Zamieroski
Writer: Alexa Billow
Scientific Consultants: Michelle Boucher, PhD Brianne Raccor, PhD Bianca Rocca, PhD
Executive Producer: Hilary Hudson
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Here's an update for you--there's new research out there that says there's no benefit of taking low dose aspirin in older healthy adults. Here's the study if you're into it: www.nih.gov/news-events/news-releases/daily-low-dose-aspirin-found-have-no-effect-healthy-life-span-older-people
no
X
There are far more studies that show it prevents heart attack by 44%
@@vampoftrance It's very good for any human if they take 75mg every other day. Of course a young fit human would have no need for ANY pharmaceuticals 😉
All the other pharmaceuticals decided to pay off a study discrediting aspirin which has been around for decades so they can push theirs. Your "study"..
Just a small audio geek note: You guys need to pay a little more attention to your audio levels. The v/o levels change frequently with the change of sections or overdubs. Not drastically but enough that I found myself adjusting the volume to keep the levels consistent.
they should change the name from baby aspirin to old people aspirin.
My mother has had 3 strokes serve enough to be hospitalized and she has been taking baby aspirin for years, so I just would like to thank you for explaining the science behind taking low dose aspirin.
Stroke can be hereditary. It cannot hurt to try. I'm sorry about your mom.
I hope she is doing fine now..❤ My mother had 4 strokes both ischemic and hemorrhagic and she is having less moment only. I hope she will recover soon. 🙏
In Germany in that case they prescribe 100mg of aspirin and cholesterol lowering drugs as prevention.
Who said its 100% stroke preventing medicine? You have so many other factors: smoking, food, air, genetics, cloth simply took of in leg,..3strokes,she should take stronger anto clothing agents tho. Sorry for your loss anyways
I know all the causes for a stroke, but that's not the video is about. The video is about how low dose aspirin, helps prevent a stroke.
Also i think i'll be sticking with the doctor's prescribed treatments rather than some random UA-cam comment advice.
Also, also i never said she died.@@gasperstarina9837
"We're here to tell you how Aspirin _works,_ not what you should _do_ with it."
Doctor poses. 👨⚕️👩⚕️🏥
At 1:49 I had the sudden desire to go shopping at Target...weird.
I just got back from Target to get some Lol
Why 81mg? Why not 80?
Can be divisible by 3
But 80 can be divided by 2? I’m just really trying to understand this too lol
Destroys your GI so you have to way out the risks
Now I understand why taking it when I have a massive hangover works! Thank you!
My sister has an inflammatory disease (Chrone’s disease) and she also takes a small amount of aspirin each day... it’s important especially since she had a stroke when she was two. Thanks, Science!
Science FTW!
Aspirin is the wonder drug
Aspirin used to be derived from Willow tree bark. Now it's being derived from petroleum processes. Some stores are selling aspirin 81 mg. 250 tablets for 99 cents. Is it the same? Do comment. Thank you.
My best friend dated the doctor who discovered this. I heard about it so much. Now I take aspirin every day for years! Thanks!
What I understand is COX-1 plays a key role for forming blood clot so blocking it out prevents new clots from forming. But what about an already formed clot staying intact? Does it play a role in that, too? If not, what I assume is blocking COX-1 with aspirin only stops new clots from forming, which is already good enough. But you've mentioned that if someone is having a heart attack the doctors give the patient 325mg of it, for... 'dissolving' the already formed clot?
I'm just guessing here, but heart attacks doesn't have to come with an immediate passing out / collapse, some can be slowly progressing over hours. If you're a ways off from a hospital taking something to inhibit further clotting seems to be a very good idea. I know of a guy (an optomitrist, funnily enough) who responded to his first attack by taking a long hot shower to relieve the felt shoulder pain (he responded well to actual medical treatment after). My question is rather: Should you always take an aspirin if you have one available if you suspect a heart attack and are a considerable distance from treatment?
Aspirin is not a clot buster. So, it does not break a clot down. Aspirin forms a covalent (irreversible) bond with the cyclo-oxengase enzyme's active site so that no further platelet activation can occur so that clotting cannot ensue.
The agents that dissolve clots are called fibrinolytic therapies and are only available at hospitals as intravenous medications. There are several marketed agents alteplase, tenecteplase and reteplase.
I think it is really about preventing further platelet recruitment that will save the patient's life. Perhaps, allowing a patient's own endogenous plasminogen/plasmin to do its job is enough to prevent significant harm. Plasmin is the compound that breaks the chemical bonds in fibrin, which is in the clot itself.
So, that optometrist actually caused his vessels to vasodilate, which is a huge factor in clot formation. When vessels are clamped down and have a very narrow diameter, platelets form clots very readily. However, once vasodilation occurs, the clot can free itself from where it is lodged or at least allow blood to circulate passed the point of occlusion. This is huge since it is the lack for perfusion that kills your cerebral, pulmonary or cardiac tissue. @@maggus999
Thanks for the insight! Because I don't know, I struggle to decide whether it's a good or bad thing to vasodilate, you only mention it's huge, but not in a negative or positive way? I imagine positive, but then again as I understand it deep vein trombosis are dangerous precisely because they break loose and lodge somewhere more critical?
The vasodilation is almost always positive. In fact, there is a negative correlation of vasodilation and thromboembolism. In cases of high blood pressure, the vasoconstriction drives the disease, which causes heart attacks and strokes.
However, it is not positive in cases of shock like septic shock and anaphylactic shock, but those have nothing to do with thromboembolic events, and those are really extreme cases of vasodilation. Thromboemboli are critical when they land/lodge in pulmonary or cerebral tissue or even a cardiac vessel. In the first case, that is a pulmonary embolus, and it has a high association with death. If the thrombus embolizes to cerebral tissue, then it is a stroke, and the last case is of course a heart attack. @@maggus999
Works on a certain part of the clotting cascade blocking a molecule called cyclooxygenase-1 (COX-1) in platelets, preventing them from becoming activated.
EXCELLENT VIDEO!!! SOOO SO INFORMATIVE!
Less than 500 views and already in my epic stuff playlist
Goood my freind from yfreind in ytube in Morocco
What about the stomach problems due to taking baby aspirin every day? There ir any ideia about that?
i believe i read somewhere that the baby aspirin has a coating so that it doesn't dissolve in the stomach but in the intestines...
Why now this channel often discuss about biochemistry, not pure chemistry?
Great video, thanks for telling separately that 325mg Aspirin should be taken during a heart attack for SOS and to prevent it in the future one might take 80mg daily as per your doctor's advice.
Trials needs to conducted on 10 mg, 20 mg, 30 mg Aspirin taken daily.
My 80 yr old mother suffering from heart valve narrowing and irregular heart beat doctor proscribed asprin and apixaban togather
Ecosprin av 75 and apigat 2.5
Please suggest us it is ok to take both medicine together or it may be any risk
Keep it upp, i love this channel!!!
Great video!
I loved this video, I would love if you did more of this kind, i. e. explaining how medicines work. I would like to know, I didn't quite understand how it is that platelets detect that there's a wound. Does it have to be something with detecting a difference in the chemistry between the blood solution and what's outside of it?
How many milligrams has aspirin
No
81mg for 2 years now
Any Benefits or Any Problems 🤔🤔
@@VS-qd3tz no Doctor keeps me on them
Why are you on them, if you don't mind me asking?
I am on aspirin 75mg, rosuvastatin10mg and exforge 5/80 for whole life by my physician on accidentally diagnosis of confirmed hypertension patient as he checked my blood pressure at an age of 35. Thanks for my physician on his preventive approach.
how are you now ?
I don’t like the music
Best video ever!
Here in Germany the normal dose is 400 rather than 385 mg, and a low-dose tablet comes out to 100 rather than 81 mg.
Jigme Choedzin Balasidis they said a full dose is 325mg.
@@MrJayPuff You're right, I stand corrected. That makes the difference all the greater. (Is my cognitive impairment due to an overdose of acetylsalicylic acid, perhaps? :-) )
Aspirin in the United States was originally dosed of the measuring unit known as grains. The 325 mg aspirin was 5 grains, where 1 grain is approximately 65 mg. So, this is how it reached it status as its dosing regimen in the United States.
@@mathematix-rodcast Very interesting, thanks.
@@choedzin, NIcht zu danken. Jederzeit.
29 liker!
S.O. to COX-I and COX-II
Thank you Doctor.
thank you
....and!....
2:05 ~
This is the one channel I have notifications on for
i am pregnant.but I did mistakenly use aspirin 75mg then what it happens
Gandekota Pravallika then what happened??
My doctor told me to take baby aspirin while pregnant to prevent preeclampsia (bc of my weight) I think you should be fine :-)
too much detail
If you want to avoid all the nonsense pointless bla bla bla go to 3:00.
Poison!!
Ah, shut up.
Do this , don't do that 🤔
So cool , how did you know that?