Why I take NMN at 22. Is it safe?

Поділитися
Вставка
  • Опубліковано 10 січ 2020
  • So I thought it was about time to do an experiment on The Sheekey Science Show, so I have started taking NMN. Why? What is NMN? Is it safe? These are all important and concerning questions that need to be asked and so I will address them throughout this video.
    DISCLAIMER; I am not trying to promote or encourage the use of NMN. The safety of NMN is not fully understood yet. This is merely me, as a scientist, explaining the knowledge that is currently out there!
    NMN video - • NMN; the what, why and...
    Scientific Reports Paper - doi.org/10.1038/s41598-019-46...
  • Наука та технологія

КОМЕНТАРІ • 200

  • @jensenachilles2766
    @jensenachilles2766 3 роки тому +31

    I'm 25 and taking NMN. Aging starts soon as you're born. Many people tell me to wait until late 30's or early 40s but prevention is key best to start early. good video btw.

    • @TheSheekeyScienceShow
      @TheSheekeyScienceShow  3 роки тому +1

      Thanks! 😊

    • @rs5570
      @rs5570 3 роки тому +12

      Well done! I love seeing a comment like this. I am 63 and have got on board with all the research I could find beginning at age 25. Discipline is required. The pay off for me has been profound. I am so grateful I have looked after myself with these protocols. I see cynicism and sad misunderstanding of this information in these comments. I am entering law school this fall to pursue a second career and my commitment to helping animals. Having said this, it is never too late to reap great benefits from this research. If you expect to see these substances packaged up on the shelves & on sale at Walmart you’ll be waiting a long time.

    • @setme4ree
      @setme4ree 2 роки тому

      Did it do anything

    • @rianeon
      @rianeon Рік тому

      @@setme4ree i dont think she would see a difference since its already high in your 20s. people that haver lower levels of NAD would probably see positive effects. its more of a preventative measure more than anything

    • @hunteralgeria1453
      @hunteralgeria1453 Рік тому

      I advise you on vitamin B3, niacin, which makes redness cheap

  • @omvilla7469
    @omvilla7469 Рік тому +3

    Excellent work all around!! In all your videos!! But I take the opportunity to Congratulate you on this one.
    You do far better work than other doctors, even some of the ones you interview.
    It must your PhD background. I am a science person, so for me it all makes perfect sense, I can even put together all these videos in my brain.... conclusion: You are The Best!👌
    Keep going, don't stop.

  • @thedreamsoldierful
    @thedreamsoldierful 3 роки тому +45

    I mean I can ask my doctor about it but I guarantee you he won’t know shit about it lol

    • @connief1919
      @connief1919 3 роки тому +1

      Of course not...ur doctor wants to keep his practice open ❣

    • @ymaysernameuay1113
      @ymaysernameuay1113 3 роки тому +11

      @@connief1919 Or he's simply not aware of the research, as aren't most people. Everything isn't a conspiracy :P

    • @manuelojeda9144
      @manuelojeda9144 3 роки тому +3

      The Conventional doctors don't know this. The modern doctors only promote Big PHARMA'S killing drugs

    • @TonyT-fz8od
      @TonyT-fz8od 3 роки тому +3

      @@ymaysernameuay1113 lmao why does everyone think everything is a conspiracy right

    • @k4y23
      @k4y23 2 роки тому +2

      Unfortunately most doctors dont keep up with the developments in science.

  • @guambianthunderbolts905
    @guambianthunderbolts905 4 роки тому +18

    I started taking this recently and I'm 31. Wish I knew about this supplement before. Wishing you a long and strong life.

    • @TheSheekeyScienceShow
      @TheSheekeyScienceShow  4 роки тому +1

      Thanks, you too!

    • @coolboy5428
      @coolboy5428 2 роки тому

      @@TheSheekeyScienceShow HI, apologies but I am not that good with science. High stomach acid means no need for methyl donor?

    • @setme4ree
      @setme4ree 2 роки тому

      Did it work

  • @ouimetco
    @ouimetco 3 роки тому +8

    Really like you videos as a long time studies of anti aging. Great work. One point though is your sound quality. It could use improving. Cheers

  • @treewalker1070
    @treewalker1070 3 роки тому +23

    I'm 68 and have been taking a gram of NMN a day for about three months, and the results have been fantastic. I have more energy than I ever had in my life. Even when I was young I would rather curl up with a book than do something athletic. Now as soon as I wake up in the morning I can't wait to jump on the exercise bike and pedal as hard as I can for half an hour. Of course, exercising creates a virtuous cycle, and I don't think you can get the full effects of NMN without exercise. But it's not like a stimulant, more like a sense of vitality.

    • @finnlichtenberg8232
      @finnlichtenberg8232 3 роки тому +2

      Hi, can you tell me the brand you are using? Thx.

    • @treewalker1070
      @treewalker1070 3 роки тому +2

      @@finnlichtenberg8232 I've been buying a brand called NMN Max from Amazon, but just started trying a brand called Livemax. Both of them have the same great deal on 3-packs of 500 mg.

    • @rs5570
      @rs5570 3 роки тому +1

      Well done.

    • @keng7758
      @keng7758 Рік тому

      @@treewalker1070 NMN Max is definitely a fake version from China. If you do a search on UA-cam you’ll find a few studies that tested NMN suppliers. If it’s cheap, it’s almost always fake. I buy mine now from DONotAge from the UK.

    • @treewalker1070
      @treewalker1070 Рік тому

      @@keng7758 Thanks for the recommendation, will check it out. I don't think what I have been using is completely inert, since I get some results, but it's possible your recommendation might be much better.

  • @RenueByScience
    @RenueByScience 3 роки тому +4

    Really great video & explanation.

  • @shackinternational
    @shackinternational 3 роки тому +1

    Would you help me to understand if taking NMN and having Gilbert Syndrome can cause an extra increase in bilirubin. Do you know anything about the pathways involved? That would be interesting.. thanks

  • @rdance3
    @rdance3 3 роки тому +4

    I recently became aware of research suggesting that NMN is converted to Niacinamide in the gut. Since I have a homozygous SNP of NAMPT, I don't feel Niacinamide is good for me and choose to cap my own, low dose (50 mg) Niacin. Do you still take NMN?

  • @jennifermcrayde3294
    @jennifermcrayde3294 Рік тому +2

    I’ve been taking NMN for 3-4 years now. I feel much youthful and also take Resveratrol, but lately I tend to feel better w/o it. Would substituted with fistein be the same to help with sertuin activation? Also, I feel TMG can make me feel nauseous if I do too much.

  • @madben9981
    @madben9981 3 роки тому

    I really enjoy your presentations, the drawings help keep me focused and you make your points well.
    Do you mind if I ask what part of England you're from? I'm curious about your accent. Thx

  • @robertflury3349
    @robertflury3349 3 роки тому +2

    "Curiosity killed the cat, satisfaction brought it back"
    The earliest form printed reference to the original proverb is attributed to the British playwright Ben Jonson

  • @victorantunez757
    @victorantunez757 2 місяці тому

    Hey, great video. Are you still taking it or have noticed anything different? I'm thinking of taking it also

  • @coolg963
    @coolg963 2 роки тому

    Was there a reason why you are taking Alive By supplements as compared to the competitors? Is it because of the published quality reports that the company has for their products or some other reason?

  • @Technikum
    @Technikum 3 роки тому +1

    How much NMN do you take and with what other supplements do you combine it?

  • @kirilgee
    @kirilgee 4 місяці тому

    Hey Great video!! Do you have any update on your experience with NMN use now that has been some time since you started taking it? Thanks

  • @conservativelatino5686
    @conservativelatino5686 2 роки тому

    Can or should you take NMN and Niacin together?

  • @disolverofsouls
    @disolverofsouls 2 роки тому

    Could taking NMN supplements reduce symptoms of schizophrenia, or is that only proven for niacine ?

  • @singhashon
    @singhashon 2 роки тому +3

    Hi . It would be interesting to see what your experience and review post 9 months of what nmn has done for you.

  • @msnewmind328
    @msnewmind328 2 роки тому

    Question: Is vitamin k2 a form of TMG?

  • @jayjayhales
    @jayjayhales 3 роки тому +6

    Do you supplement with any other anti aging compounds?

  • @zibtihaj3213
    @zibtihaj3213 3 роки тому +2

    So in summary NMN is worth taking ... what about Resveratrol with it ?

  • @catman4471
    @catman4471 3 роки тому +1

    Just wondering if you should be taking it at your age? You'll find the people who sing it's praises the most are the older generation. I got fantastic results aged 58 within two days of taking it, and that was only at low doses. But you'll have no lack of sirts at your age, so is there any point?

  • @kabl00muk94
    @kabl00muk94 3 роки тому +8

    Very interesting as I've been taking NAD boosters for a while now, could methods like 'high intensity training', 'Wim Hof Method' and fasting negate these side effects, given the induced autophagy and the body's utilisation of fats and keytones over carbohydrates?
    I do try to find the answers to these questions myself, but it gets difficult in such an emerging field as this as there doesn't seem to be enough research available and certainly no long term studies as you point out here 😅
    Love the videos, stuff like this is the best way to help people break down the information available in a clear and concise way 👌🏻
    Keep up the good work! 🙏🏻🙏🏻🙏🏻👍🏻

    • @lastraven7205
      @lastraven7205 2 роки тому +1

      what are you taking

    • @kabl00muk94
      @kabl00muk94 2 роки тому

      @@lightbeingpontifex good to know thanks 👌🏻👍🏻

    • @kabl00muk94
      @kabl00muk94 2 роки тому +1

      @@lastraven7205 nicotinamide ribocide along with resveratrol every other day currently

    • @kabl00muk94
      @kabl00muk94 2 роки тому +2

      @@lightbeingpontifex sorry, the full shopping list I take also includes omega 3, COQ10, vitamin D, creatine, ashwaganda, alpha lipoic acid and biotin 👍🏻

  • @jozefwoo8079
    @jozefwoo8079 2 роки тому

    Do you still take it now?

  • @EJ-jh1vf
    @EJ-jh1vf 3 роки тому +4

    Didn't expect there to be someone younger than me already interested in longevity.

    • @EJ-jh1vf
      @EJ-jh1vf 3 роки тому

      @Solomon D'Or I've been learning to balance the two pursuits, I use to work 80 hours a week work + projects/business. But upon doing some research I found people who work too much don't live as long. Trying to hold out as long as possible, if we can hit LEV in out life times we might be able to do a lot of good.

  • @catorepublic
    @catorepublic 4 роки тому +5

    Sheekey,
    Your videos are fun to watch and informative. NMN looks promising but if you listen to Rhonda Patrick's interview of David Sinclair at minute 58 he says that NMN needs to be kept cold. This raises the question as to whether the NMN one is taking was kept cold during any warehouse storage and during shipment.

    • @TheSheekeyScienceShow
      @TheSheekeyScienceShow  4 роки тому +3

      Thanks and yep, you are right, what happens between production and receiving goods is a but of a black box. How much it could cause degradation is unclear, as the degradation rate is not known. The best thing you can do if you are keeping NMN long-term is to make sure that you keep it refrigerated as soon as you can.

    • @pascalbleval7215
      @pascalbleval7215 4 роки тому

      More precisely, he says that unstabilized nr has to be kept cold. If you ask Alive by nature, and i did, they say their nmn is stabilized. However, i still keep it cold once it arrives. I have not yet begun to take it, as im unsure of the effect of taking nmn in this time of covid19 pandemic, though. What are your thoughts on this, btw ? Would taking nmn be safe ? Also, David Sinclair does take resveratrol (which activates the sirtuins and help prevent aging effects too) as well as aspirin to prevent inflammation.

    • @TheSheekeyScienceShow
      @TheSheekeyScienceShow  4 роки тому +1

      @@pascalbleval7215 Thanks for the comment and i was thinking the exact same question. Will do some research into it, but feel like always it would be based on assumption not fact due to our limited knowledge on both nmn and Sars-cov-2!

    • @pascalbleval7215
      @pascalbleval7215 4 роки тому

      @@TheSheekeyScienceShowsure thing. No studies, as of yet, of course

    • @RenueByScience
      @RenueByScience 3 роки тому +1

      Understandable concern. I can share a bit of information & our stability information. Every company will have different protocols (some have very few, unfortunately). We test every batch of raw material when received, and every batch of finished product. We list test reports with batch number on our product pages.
      We hold products in a climate controlled room and send a bottle for testing at 2, 4, and 6 months, and find less than 3% degradation on powder, a bit less for tablets. It does not do well at temperatures over 110 for several days, but is just fine at room temp and does not require refrigeration unless you have more than 6 months of inventory.
      We don't recommend anyone ever buy more than a few months inventory, and we don't sell in larger than 100 gram bags, as the price is constantly dropping, so you are actually wasting money by making a large purchase. Prices just dropped greatly. As for the raw material, there is some difference in stability depending on physical structure, ph, moisture content, etc. The more established mfg have learned this and provide a much more stable product now vs a few years ago. Buyers can be assured that at 6 months it is close to 97%, with some degradation to Nam. We have not yet had a batch last more than 2 months before selling out, so there is no degradation when they get it from us.

  • @Na-ez6mz
    @Na-ez6mz 2 роки тому

    im 16 should i be taking supplements or no

  • @k4y23
    @k4y23 2 роки тому

    ur videos are very interesting . May i recommend you do something about ur microphone? the sound needs some bass.

  • @khalidhusain5569
    @khalidhusain5569 Рік тому

    can you upload this page for us?

  • @davidcarljones7565
    @davidcarljones7565 2 роки тому

    Dr Brad recommendation is to take Niacin as a precursor when you are young

  • @ababoo99
    @ababoo99 3 роки тому

    Why NMN rather than NR?

  • @ddutton4716
    @ddutton4716 3 роки тому

    Don't AKGs inhibit SASPs?

  • @michaelvaughan2888
    @michaelvaughan2888 4 роки тому +3

    Good channel by the way you present information well

  • @eldjanbeqiri2298
    @eldjanbeqiri2298 Рік тому

    How are you doing with NMN?

  • @Jade-sm3pk
    @Jade-sm3pk Рік тому

    Thank you for doing your videos :)

  • @bernhardwalther
    @bernhardwalther Рік тому

    Great video. Do you still take NMN?

  • @mrp7789
    @mrp7789 3 роки тому +2

    What diet do you stick to? I would choose for a (raw) WFPB nutritarian diet, that diet is without side-effects and has proven to slow down aging considerably. I wish I knew that when i had your age. I take resveratrol and I used to take NR but will switch to MNM. I can't take methformin my stomach does not allow it.

  • @btkw
    @btkw 3 роки тому +12

    Hi! Can you do a video on the difference between NMN and NR? I have been taking NR and I am wondering what the differences are between the two supplements.

    • @rdance3
      @rdance3 3 роки тому

      imgur.com/a/T1hJ71P

    • @rdance3
      @rdance3 3 роки тому +1

      As you can see, they both feed into the same pathway. NR just has one more enzymatic step.

    • @catman4471
      @catman4471 3 роки тому +1

      I've taken both. If there's any differences, they're only subtle.

    • @aaa-my5xy
      @aaa-my5xy 2 роки тому

      if you ever see this i think this answers your question: ua-cam.com/video/0SilTZO1GW0/v-deo.html

  • @deepthinkingeconomics1367
    @deepthinkingeconomics1367 3 роки тому +2

    Let's say my nad lvl is a 100 if I don't supplement with nmn and 150 with nmn. I'm wondering if stopping taking nmn will decrease my nad lvls to the baseline at a 100 or will it be lower ?? This is my only concern.

    • @Gabibing
      @Gabibing Рік тому

      I'm also wondering this. did you find the answer?

  • @clarehazell2097
    @clarehazell2097 4 роки тому +4

    Hi - interested in your TMG comment. How much do you think is required to complement NMN. Do you think 1g is required if you take 1g of NMN. You suggest maybe less is adequate. Thank you.

    • @TheSheekeyScienceShow
      @TheSheekeyScienceShow  4 роки тому +4

      Thanks for your question. Unfortunately, i have not seen any studies regarding this so cannot say for certain. I can only recommend taking the suggested daily dose!

    • @catman4471
      @catman4471 3 роки тому +3

      I don't think there is any reliable info on doseage or even if it is essential to take TMG, it seems to be reccommended as a precaution. I started taking equal amounts of each but honestly don't know if I'm just wasting money on the TMG. I now take between 500mg and 1g of NMN per day and 500mg every two or three days just to use up what's left.

  • @davidwelburn
    @davidwelburn 3 роки тому +1

    It says on the bottle of that brand of NMN that you are taking, that you should take 4 - 8 capsules per day. That makes it ridiculously expensive. Is there a cheaper alternative that can give similar results? Maybe just plain niacin (does it really matter about a bit of skin tingling/flushing)? Thanks.

    • @ballapalleballe
      @ballapalleballe 3 роки тому +1

      If you go for powder instead of tablets the price drop substantially - a tip is to look for the 100 gram powder bag

    • @davidwelburn
      @davidwelburn 3 роки тому

      @@ballapalleballe Thanks, Paul. I will look for that.

  • @Venom0007
    @Venom0007 3 роки тому

    Im pretty sure Dr.Rhonda Patrick had a video on this were she said studies suggesting poor bioavialabilty , and most were all on animals . It seems the miniscule effect only was noticible mostly in the liver. It wasnt that long ago either .I might be wrong here , havent compared videos .

  • @SumitNangia_SN
    @SumitNangia_SN Рік тому

    question - is vitamin B3 (niacin) a precursor to NMN?

    • @thexeberg
      @thexeberg Рік тому

      Yep. At 16 mg a day (100% DV) its not too much, tho. Eight months wait lol

  • @grahamfleming9179
    @grahamfleming9179 3 роки тому +10

    Eat plenty parsley and basil to keep your nad levels up it's cheap too anyway keep up the good work

    • @CMAV8202
      @CMAV8202 2 роки тому

      Why parsley and basil? Do they contain high levels of Niacin?

  • @kingbile5846
    @kingbile5846 2 роки тому

    product describtion link

  • @Mariam-fx9rv
    @Mariam-fx9rv 2 роки тому +1

    Hi!! Do you take nmn sublingually? What is the best way to take it?

  • @kamilkashaf2766
    @kamilkashaf2766 4 роки тому +12

    I don't think NMN or NR is converted to Nicotinamide in the gut before being converted to NAD. In fact, Nicotinamide might be produced as bi-product of the intial conversion to NAD, although this residual product has the potential for NAD reuptake after being synthesized by NAMPT. However the amount of Nicotinamide that can be converted to NAD by the body is rate limited in terms of bioavailability because of the reliance on NAMPT. For this reason, is referred to as the "salvage pathway".
    I am 23 years old myself and after debating between Niacin and Niacinamide, I settled for Niacin (I can't quite afford those hefty NR/NMN supplements quite as yet). The reason that I went with Niacin is because, Niacin results in NAD uptake through the NAPRT (Preiss Handler) pathway, with the NAMPT route as the secondary or backup method. My sense is that diversifying the pathway to boosting NAD levels should in theory yield better results.
    The other thing I worried about when considering NMN/NR as an option was that they are photosensitive and there is a high chance be converted back to Niacinamide if not stored properly, especially with NR. A poorly handled NR pill might in fact be doing less than plain old Niacin. However in theory, yes NMN and NR should yield the best results because they are a step forward in the reaction chain, having bypassed the stage for which Niacin and Niacinamide require NAPRT and NAMPT synthesis respectively.

    • @danno1800
      @danno1800 3 роки тому +3

      Kamil Kashaf Very well explained! Thank you and good luck with your choices.

    • @mrincredible3241
      @mrincredible3241 3 роки тому

      👏👏👏

    • @rs5570
      @rs5570 3 роки тому

      You are very handsome.

    • @kamilkashaf2766
      @kamilkashaf2766 3 роки тому

      @@rs5570 Thank you! 😊

    • @lastraven7205
      @lastraven7205 2 роки тому

      @@kamilkashaf2766 What would you take and at what dose ideally? NR and NMN?

  • @ApplePotato
    @ApplePotato 3 роки тому +5

    For young people the increase in NAD+ probably won't harm you. Recent studies have shown that many form of cancer cells require large amount of NAD+ to survive. Without enough NAD+ some cancer cells will die on its own. The decrease of NAD+ as you age is probably a evolutionary defense mechanism to cancer.

    • @michaelbarry8373
      @michaelbarry8373 Рік тому

      "The decrease of NAD+ as you age is probably a evolutionary defense mechanism to cancer." I really don't think that would be the case. Aging itself increases the chance of cancer, a certain mutation of DNA , change in mitochondria. Then may use NAD. Cancer will then take advantage of whatever it can use. Your body becomes a playground for cancer. Cancer will now have your body. it takes over from there.

    • @henryhengheng9626
      @henryhengheng9626 Рік тому +1

      Yes that is right. Elderly people have to be careful.

    • @henryhengheng9626
      @henryhengheng9626 Рік тому +1

      Yes the defense mechanism is increased CD38 which consume a lot of NAD+.

    • @scottp6761
      @scottp6761 Рік тому

      Well FDA now banned NMN for this very reason cancer

    • @saradoherty3875
      @saradoherty3875 Рік тому

      and how do you think that turned out??

  • @surfreadjumpsleep
    @surfreadjumpsleep 3 роки тому +4

    Dr. Brenner says that NMN cannot be taken into the cell directly. He says that it is likely first converted to NR and then back into NMN within the cell. He was the one to originally discover that increasing NAD+ in the cells improved function & ameliorated disease states.
    Yet many take NMN. So what details did I miss here? Thank you!

    • @TheSheekeyScienceShow
      @TheSheekeyScienceShow  3 роки тому +1

      Don't think you missed anything! Have not fully committed to nmn or nr and am always curious to see the latest work!

    • @surfreadjumpsleep
      @surfreadjumpsleep 3 роки тому +1

      @@TheSheekeyScienceShow Well in all honesty I think I am missing a lot of the picture. Must be some reason why many people take NMN despite the researcher who supposedly discovered the NAD+ decline not agreeing with that route. Do you know Dr. Brad's videos? He also does not want to take NR, but prefers NMN sublingual and his reasoning is something to do with the stress on the liver. But I may have messed that up too.

    • @TheSheekeyScienceShow
      @TheSheekeyScienceShow  3 роки тому +3

      @@surfreadjumpsleep sure, well i think most of the picture is still missing!! I don't think I have seen enough evidence to support either NMN or NR being superior.

    • @youtubeyerr
      @youtubeyerr 2 роки тому

      dr david sinclair recommends nmn over nr. In yeast and mice, nmn showed stronger effects on health and life expectancy. Directly taking nad was shown to have no effect because the molecule is too large. NMN is most likely greater than NR.

    • @henryhengheng9626
      @henryhengheng9626 Рік тому

      NMN produces better results than NR

  • @cypriano8763
    @cypriano8763 3 роки тому

    1-what are you taking to replenish methyl groups
    2- can niacin be an adequate and cheaper alternative to nmn
    3- do we absorb enough nmn to make this expensive supplement worth it
    4- do you take resveretrol or extra virgin olive oil as well

    • @TheSheekeyScienceShow
      @TheSheekeyScienceShow  3 роки тому +1

      1. I have some tmg.. But still not seen data if this is effective or required. 2. Not been directly compared 3. Not known and will vary in many things e.g source, how and when you consume

    • @RenueByScience
      @RenueByScience 3 роки тому

      @@TheSheekeyScienceShow Some people add a whole blood histamine lab test to their annual bloodwork if they want to check on the status of that. But, it seems you are right that there may not be much data on it now.

  • @user-lu6ce4yc9g
    @user-lu6ce4yc9g 4 роки тому +4

    Good you take nmn and in low dose . I am 23 i take it too just 100 mg. Also i take resveratrol but dont think it really works better would be berberine but than no energy because of atp inhibition it also is a telomerase inhibitor( maybe telomeres arent that really important). I read studies nad should boost ampk by activating sirtuins.

    • @TheSheekeyScienceShow
      @TheSheekeyScienceShow  4 роки тому +6

      Cool. I don't know much about berberine and am too interest to understand how different molecules work in tandem - in theory both NMN and resveratrol would synergise since resveratrol activates sirtuins and NAD is used by sirtuins as a cofactor - but also at 23, with exercise, sleep & healthy diet, atleast i think it is hard to tell if anything is really "working"

  • @michaelvaughan2888
    @michaelvaughan2888 4 роки тому +2

    Shouldn’t it be anti inflammatory? Because NAD helps remove senescent cells?

    • @TheSheekeyScienceShow
      @TheSheekeyScienceShow  4 роки тому +2

      So the reason i suggest it could have an inflammatory effect is based on this one recent publication (www.nature.com/articles/s41556-019-0287-4?proof=true) that showed NMN enhanced the SASP of senescent cells. The SASP is what makes senescent cells pro-inflammatory. However, there is also evidence that boosting NAD+ can aid removal of senescent cells which as you say could have anti-inflammatory effects. So, currently there doesnt seem to be a definitive answer! Hope that helps!

    • @dannyiskandar
      @dannyiskandar 3 роки тому +1

      @@TheSheekeyScienceShow so now there are 2 'papers' that basically contradicting each other? One shows NAD+ enhanced the SASP, and one shows aid in removal of senescent cells. How do we judge this?

    • @TheSheekeyScienceShow
      @TheSheekeyScienceShow  3 роки тому +3

      @@dannyiskandar Be cautious until there is more data!

    • @dannyiskandar
      @dannyiskandar 3 роки тому

      @@TheSheekeyScienceShow how about resveratol? is the study is more conclusive than NMN?

    • @TheSheekeyScienceShow
      @TheSheekeyScienceShow  3 роки тому +2

      @@dannyiskandar ua-cam.com/video/QTMW8CCAhZc/v-deo.html spoke about it recently, but similar that we still dont know enough!

  • @danielwiczew
    @danielwiczew 3 роки тому +3

    What's the point to take NMN if B3 is more studied and cheaper ?

    • @catman4471
      @catman4471 3 роки тому

      I take both. Flush Niacin can replace statins for high cholestorol, but also makes you sleep, whereas NMN adds to your active ability while awake:)

    • @danielwiczew
      @danielwiczew 3 роки тому

      @@catman4471 But Niacin does not reduce chance of death, where statins do. So high Niacin fail to replace statins, and opposite is a false claim.

    • @catman4471
      @catman4471 3 роки тому

      @@danielwiczew What's your source of information? You'll find there's a lot of criticism of statins. I take both btw, I have a totally occluded right artery and suffer angina. The statins cause all sorts of muscles pains. At the right doses, around 3g of Niacin per day, I can walk or exercise much longer without taking my anigina tablets, and this is on days when I don't take statins. I can't say the same for just taking statins. From what I remember, studies of replacing statins with niacin done from a pharmacological point of view have reported only on short term use of niacin.

  • @johnmcewan879
    @johnmcewan879 3 роки тому

    If NR increases NAD+ without the homocysteine problem, why not take that instead of NMN?

    • @TheSheekeyScienceShow
      @TheSheekeyScienceShow  3 роки тому

      Good question. Niacin at higher doses has been shown to have unwanted side effects e.g flushing, insulin sensitivity. In term of efficacy of increasing NAD+ levels is really hard to say based on current data as no direct comparisons have been made!

    • @johnmcewan879
      @johnmcewan879 3 роки тому

      I should have been more specific. Why not take Tru Niagen, which I understand doesn’t cause flushing.

    • @scottp6761
      @scottp6761 Рік тому

      NR > NMN > NAD. NR is a smaller molecule and therefore gets into our cells better then NMN. And NR is safer in regards to the homocysteine issue. And you'll have more NAD levels from NR then NMN alone. They are all precursors to each other

    • @scottp6761
      @scottp6761 Рік тому

      @@TheSheekeyScienceShow NR is name the same as Niacin in it's form. Niacin causes flushing yes. NR no.

  • @jimperkins9661
    @jimperkins9661 3 роки тому

    Recently started on nmn. Even more recently (as in shortly thereafter) experienced severely uncomfortable constipation. Anyone else?

    • @catman4471
      @catman4471 3 роки тому +1

      Nyes (sic). When I started NMN I didn't get any bad side effects, only positive ones, but I started adding more and more supplements. I started to get constipation but after a few days of this I became 'normal'....for the first time in many, many years. I usually have either one extreme or the other but never normal so if NMN helped to normalise me or if it was the other supplements, I don't know.

  • @omvilla7469
    @omvilla7469 Рік тому

    And for other audience that keep asking you about what you will get out of it, only time will tell... talk to you in... 50 years... ok?😎✌
    - I would only suggest to you and other young people. Take it intermittently, give it a break every 2 or 3 months, all in excess has always had negative effects. We should let our bodies do the work sometimes...😉🖐

  • @callummarks2080
    @callummarks2080 Рік тому

    Hrm.. You take NMN too!! Lol. I've also hopped on this band wagon and am using "Nad+ Complete by Renue BY Science and I also got a bottle of the 240 Dissolvable NMN's like you. Only tried a few days ago and will see how I go, so far I haven't "received" any of the said benefits like the focus and energy so I'll just see how I go I guess. Will cycle from The "NAD+ Complete to the dissolvable NMN's after a few months to see what it's like, I'm also ordering 100 grams of NMN powder in a few days also and will try that at some stage. It's probably too early for me to say but I'll see in a month or 2 if all the said benefits are hype or its true! Time will tell.. 😎👍

    • @hunteralgeria1453
      @hunteralgeria1453 Рік тому

      I advise you to take Vitamin B3 Niacin with Flash work work nmn

  • @mindcache5650
    @mindcache5650 Рік тому +1

    Oh dear . Sucked in my marketing. Niacin does the job and it’s 75% cheaper .

    • @hunteralgeria1453
      @hunteralgeria1453 Рік тому

      Yes, it is true, and I advised many commentators on the video to take niacin because it is cheap and has the same action and is stronger

  • @CrumbleLives
    @CrumbleLives 3 роки тому +1

    What about increased risk of cancer?

    • @PackCentral
      @PackCentral Рік тому

      if anything, wont it reduce your cancer risk

    • @despairingleonardo
      @despairingleonardo 10 місяців тому

      Its fine if u dont have cancer. If u discover u have cancer, it helps to grow

  • @lucaskazama878
    @lucaskazama878 4 роки тому

    In my country NMN (Nicotinamide Mononucleotide) is very very expensive, so could you tell us more about the other alternatives like Nicotinamide riboside, less expensive here at least, but it appear to be more instable. Also about the other vitamin B3 variants, do they serve for something?

    • @TheSheekeyScienceShow
      @TheSheekeyScienceShow  4 роки тому +2

      NR and NAM are alternatives that can be cheaper, and there are also cheaper versions of NMN available, but then it also comes down to whether you can trust the composition of the supplement and as you say, how the efficacy varies between them is just not fully known yet. If you want to save money, the best strategy is to eat more foods that contain NMN e.g cucumber, broccoli, avocado - sure, this doesnt match the equivalent of that in supplements but it is a cheaper place to start and is better than a poor diet (+) NMN supplementation. Hope that helps.

    • @lucaskazama878
      @lucaskazama878 4 роки тому +2

      @@TheSheekeyScienceShow thank you Sr Eleanor for the information about the foods that contain it. Not sure if the foods can provide a minimum necessary for any effect (just as wine alone equals almost nothing compared to the concentred synthetized Resveratrol), but you were the first channel to put it in perspective. (you could make a video about it, there are none known for now, here on youtube, provided by a technical person in the field), and there are people like me around the world that don't have access to NMN providers.
      About not having a provider: Not only NMN is very expensive to get it in my country (Brazil), since the value of Dollar compared to our currency is very very expensive, plus taxes for transport and importation here are absurd as well, (for you to have a perspective, a simple bottle with capsules for 30 days, can be equivalent of {1/3} or even {1/2 } of the salary of the general population here), so, it's absurd expensive here, but also there are other factors of disadvantages:
      1 - There are so many providers now, that it is very difficult to know who really is doing it right, even more knowing there are frauds that can sell it for a cheaper price since it is difficult to have it.
      2 - As dr Sinclair always mentions in his interviews, he explains how NMN can change its composition if not stored in cold places, doing more harm than good in case it (alterations) happens. So the route from a country that produces it to other countries will probably never be refrigerated for this, creating a big risk.

    • @kamilkashaf2766
      @kamilkashaf2766 4 роки тому +5

      @@lucaskazama878 Niacin, but make sure to not exceed 1g per day as it might have slightly higher toxicity that NR and NMN, and make sure to co-supplement it with TMG. Make sure it is Niacin and not Niacinamide because the later has a rate limiting factor in its conversion to NAD, because it exclusively involves the need of an enzyme for synthesis (NAMPT) whereas Niacin uses two different pathways (NAPRT+NAMPT), meaning that mg to mg, Niacinamide becomes less effective at boosting NAD after a certain threshold level, significantly earlier than Niacin.

    • @blokeabouttown2490
      @blokeabouttown2490 3 роки тому +1

      @@kamilkashaf2766 Good info Kamil, thanks.

  • @DF-dx1ef
    @DF-dx1ef 3 роки тому +2

    Have you read the study on Niacin on NAD. It is has shown to boost NAD and it is known as safe in long term studies. I do take 1 gram of Niacin every other day and other than flushing (which i do not mind) it does seem to work for me.

    • @TheSheekeyScienceShow
      @TheSheekeyScienceShow  3 роки тому

      I spoke about Niacin here --> ua-cam.com/video/2oIPTvcs2GU/v-deo.html Is this the study you mean?

    • @DF-dx1ef
      @DF-dx1ef 3 роки тому +1

      @@TheSheekeyScienceShow Thank you, I did watch the video and yes I am referring to that study. I personally take Niacin as we know it is a safe (and cheap) molecule and it is one of the NAD+ pathways and even though this is a small study it does look like it boosts NAD+. I do take NMN at a low dose, but my primary molecule for boosting NAD+ is Niacin given it has been study for safety for a much longer period of time. I was wondering if you have incorporated Niacin for these reasons?

  • @lloydfromfar
    @lloydfromfar 3 роки тому +1

    I am confused you feel the need to get NMN at only 22! But hey it's your money...
    Thing is, as far as I understand it (and I am by no mean anything remotely like a biologist) this doesn't rejuvenate the body at all, but it acts closest to the root of metabolism weakening as we age... but it's only like.. a very good clutch?
    I am taking it for .. 6 months? now.. Initially it feels like it was doing nothing (cant complain about secondary effect here!) but.. my eye aches, which I had worsening for a few years now.. slowly decreased to very mild.. so it's definitely doing something...

    • @rs5570
      @rs5570 3 роки тому +1

      At 22 a person has most likely completed growing. As soon as full growth is reached deterioration and degradation begins. That fact makes it very prudent to begin these protocols now.

  • @Amazingnordicviews
    @Amazingnordicviews Рік тому

    Are you just 22?

  • @PROTAGONIST_48
    @PROTAGONIST_48 Рік тому +1

    Careful people, the brain continues to develop until the age of 25.

  • @KenOtwell
    @KenOtwell Рік тому

    Curiosity killed the cat... but satisfaction brought her back!

  • @rui-9-cs315
    @rui-9-cs315 3 роки тому

    💕

  • @manuelojeda9144
    @manuelojeda9144 3 роки тому

    I wouldn't take NMN as a supplement. Till there is more human DATA.

  • @randelcooprider6013
    @randelcooprider6013 3 роки тому

    Elevated homocystine levels have been associated with cardiac disease. Don't risk it.

    • @scottp6761
      @scottp6761 Рік тому

      So does eating potato chips and cookies. I'll take my risks with it. I feel great

  • @happydude4152
    @happydude4152 2 роки тому

    Curiosity killed the Cat 🙀, Satisfaction brought him back 😺 meow

  • @gravelman5789
    @gravelman5789 3 роки тому

    im 24,000~ days old.
    😆😆😆😆
    ive been using megadoses of vitamins amino acids and minerals for 12,000 days...😁😁😁
    you are showing me a Whole New World....
    lets see if i can bust 75,000 days......😆😆😆

  • @luckspell
    @luckspell 3 роки тому

    I heard dr birkjmayers nadh is better

  • @lucaskazama878
    @lucaskazama878 4 роки тому +2

    so Sr eleanor sheekey, dont you think you could make a fortune by entering this industry instead being just a reasearcher for universities? I get sick just to think about how many industries are forming around Sinclair's book, and he and his collegues earn just a small ammount from it, amost nothing in comparison. I'm sorry, I know nothing about the topic, I just get so upset about industries generated around the people who discover things, then they get almost nothing from it in proportion.
    Another thing: Hey dr. sinclair is taking almost every interview he can get (via webCam), you could use it to push your channel on youtube.
    just random thoughts.

    • @TheSheekeyScienceShow
      @TheSheekeyScienceShow  4 роки тому

      True point, i agree, which i think will escalate if aging is ever approved as a disease by FDA. Many scientists do advise for companies and/or have their own start-ups, but other scientists enjoy the satisfaction of getting results, not the business end of it. But i am not entirely clued-up on this either as am still pretty new to the field of research.

    • @rs5570
      @rs5570 3 роки тому

      She is 22 and likely still educating herself at the graduate level. A bit presumptive to claim to know what she is doing never mind what her future plans will be. Why be upset over people making money? Sinclair is doing very well indeed. No need to worry over his finances or those of other researchers. Focus on the humanitarian benefits that can result from this work. There are opportunists in every endeavor of life, as always.

    • @lucaskazama878
      @lucaskazama878 3 роки тому

      @@rs5570 Humanitarian benefits? Are you insane? After Nikola Tesla, every very intelligent human being should worry about one thing: his own life. While this comment I did is very old, and lots of things have changed, the will to profit and power have not.

  • @ymaysernameuay1113
    @ymaysernameuay1113 3 роки тому +1

    Yeah I'm 22 but I'm pretty sure my biological age is like 40 because I barely sleep and don't exercise at all.

    • @PackCentral
      @PackCentral Рік тому

      you can test your biological age with some services u can google

  • @birage9885
    @birage9885 3 роки тому

    Recent study shows NMN to be 25% absorbed. Too expensive for that type of results. This science is constantly emerging. we know things about resveratrol that we didn't know before. I wouldn't jump on any of these things until more proverbial fat ladies sing.

  • @antonmoller624
    @antonmoller624 3 роки тому +1

    I’m pretty certain that at age 22 you needn’t be taking any anti aging supplements 😉

    • @squamish4244
      @squamish4244 3 роки тому +1

      Taking anti-aging supplements at the age everyone wants to be lol

    • @peteplayz-norskgaming5723
      @peteplayz-norskgaming5723 Рік тому +2

      Eh, no. Remember the principles of proactivity, prevention, earlier the better, and so on and so forth

  • @revealanation7778
    @revealanation7778 Рік тому

    You talk way too fast

  • @Orangestardust
    @Orangestardust 3 роки тому +1

    Your 22?! I thought you were at least 30. THE NMN's NOT WORKING! Just kidding 😂. I mean the way your so knowledgeable and how professional your videos are makes you seem older. I don't think you should be taking NMN at 22. I'm 41 and I felt I was too young to take it. NAD+ levels start decreasing after 40 and really drop off at 60. The problem with NMN is it's essentially cancer food. When cancer develops, NMN is like super growth fertilizer. My father who is an 80 year old doctor with 90% coronary arterial blockage takes NMN because cancer isn't likely to kill him. Heart disease and old age related conditions will likely kill him. In a 20 year old taking NMN is downright silly and dangerous. Just eat right, exercise and don't drink and you'll be perfect. Maybe start when you hit 30.

  • @irock5624
    @irock5624 3 роки тому +1

    you talking in a box or something?!