Imprinting and Uniparental Disomy for the USMLE Step 1

[@telatti]

the best video on uniparental disomy i've found! thank you so much :)

[@physeo-USMLE]

Thanks for the support! We're glad you like it!

[@telatti]

@@physeo-USMLE thank you for helping me learn :)
struggling med student from czech republic

[@physeo-USMLE]

@@telatti You've got this!

[@vineshmanohar2060]

Can’t get any clearer than this. Thank u so much :)

[@physeo-USMLE]

❤😎

[@faiziiiiii]

love you, just in the first 2 minutes you explained what I've been trying to understand for years. I am beyond greatful for this! Thank you again!

[@pawandeepkour544]

Best video on Imprinting and Uniparental disomy I have come across.👌🏼

[@Alexandra-sd4yy]

My colleagues need to know about this channel! Thank you for the beautiful teaching!

[@ashozy1003]

Excellent video which is underrated.. I'm not a native speaker or from US, but sir I loved your video it's very helpful. Thank you !

[@batol5361]

You are such a legend. Thank you helped a lot truly! Keep up the good work!🥰

[@amiramadhi2074]

Best video on uniparental disomy thank u so much 🌸

[@pallaviguha9354]

Thank you so much! I was having such a hard time understanding uniparental disomy😭!

[@opoppo6413]

the best I found on UA-cam I think

[@abijeyarajan2173]

Very clear explanation on imprinting. Thank you 😊

[@saadsohail9379]

cant thanks enough........ May Allah blessed u

[@sadmanchowdhury9823]

Incredible well explained. God bless you!!

[@riflemusket]

OK. For proper cytogenetic nomenclature, 15q11 is read as "Fifteen-Q-One-One", not "Fifteen-Q-Eleven". Same with 15q13 -> Fifteen-Q-One-Three.

[@workation6663]

thank you so much)))) u helped a lot

[@cakuh8900]

in Germany we dont say "good video" we say: "geiles Video Bruder, du bist ein geisteskranker Ehrenmann", and i think thats beautiful.

[@saul3965]

Spectacular, Im reading over this for my medical genetics and the book did not make it easier.

[@DazeOpYT]

In your question about Prader Willi Syndrome, it's also likely that the father underwent a mutation in the imprinting gene which causes the methylation of the paternal PWS-gene and thus the wrong imprinting pattern. Just a side note, your video explains it very well :D

[@DazeOpYT]

@Rudolph Rudolph Not necessarely, there can also be a misstep in the meiotic splicing of the cell which causes the child having to maternal copies.

[@studiesaura]

This is lit 🔥 Thank you so much.

[@umerkhan7545]

Very nicely done

[@divyeshkhatri2538]

Excellent explanation 😋😋😋😋

[@markmegaly1626]

Awesome Content! Keep it up. Thank you

[@maryamhani7725]

Nice presentation

[@nesrinech3967]

you made it so easy to understand , thanks a lot.

[@azadbharath7444]

In a RFLP related question -boy has symptoms of praderw ,means paternal deletion,means at the time of fertilitzn incompatible trisomy caused by incoming spem,so incoming paternal gene chr deleted,is that so is only possible by maternal disomy by nondisjunction M-1#opt-a???&M-2,means is aspermatogenes view na ,so paternal disomy -un compatible trisomy by incoming maternal ova.

[@juliaaysenurturkozeaston]

Thank you so much 😊

[@faizanshahzad8598]

Awesome vid with a clear explanation, Kudos 2 u :)))

[@arzofaqiri-aksoy6857]

thanks a lot, best explanation ever

[@namrtasharma335]

best video, appreciate ur work

[@Sparrow6_]

That’s a very good explanation 🤝🤝

[@mandyads]

5:47 for heterodisomy vs. isodisomy

[@andrewpleva]

Great video thank you you much!

[@ivangrishin8547]

Perfect explanation

[@lotfiadj5896]

much love from algeria

[@cubba20]

amazing video

[@Salopovpaz]

Thank you very much. God bless you 🙏

[@jared394]

Killed it!

[@phantasmalphasmidzoo8280]

So if an embryo has a deletion of the pws gene of the male side, can you avoid Prader Willi by demethylating the pws gene on the female side??

[@benjaminazumah9833]

No because unlike histone methylation, DNA (cystine) methylation is almost always irreversible.

[@revanthsurapaneni6258]

Thank you man!

[@crichighlights2612]

Nice explanation bro! Couldn’t understand the concept in other channel videos.✌️

[@burns1606]

great video!

[@drswekcharanjan7481]

Really good

[@Robertson284]

awesome. thanks a lot

[@salehFayoumi]

thanks a ton , many many thanks

[@physeo-USMLE]

❤

[@oviyagnanasekaran2756]

How exactly does the cell loose a chromosome during fertilisation?

[@manuelgoncalves9753]

great video

[@mellowdoctor9029]

Boss of the bosses

[@muntehakhatun7783]

Thanks👍

[@samarthchauhan6289]

what about monosomy rescue? can't this mean PWS can occur following nondisjunction in sperm

[@Alexandra-sd4yy]

so is it a problem if it is heterodisomy? the cromosomes are different, one from grandpa and one from grandma, right???

[@ishanisingh862]

Thank you 😊

[@femidaelettil1002]

Thanks a lot

[@iw16n17]

thank you so much

[@ibraheemalma]

beautiful
thank you sir

[@ahlamal-bloshi9656]

THANK YOU

[@GermanHeul]

Amazing thx 💗

[@iknowiamwrong.butstill...2073]

amazing

[@arnebshaikh]

😍😍👍🏻👍🏻

[@DoctorKlenk]

4:35 B is just as likely

[@mellowdoctor9029]

❤️

[@jrh1677]

Wow

[@jesiraj2448]

It is a clear explanation, but please do not say q eleven instead it is q one- one ...

[@zainab_abd3776]

مرحبا
ممكن أعرف اذا كنت بدرس دروس خصوصية لمواد المجموعة الطبية
؟؟؟

[@jenniferjdaidani1397]

THANK YOU

[@rawanaimat2367]

thanks a lot