Do blood sugar spikes cause heart disease? [Study 287-294 Study Analysis]
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- Опубліковано 12 лип 2024
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Studies & Amendments: bit.ly/PhysionicGlucoseSpikes...
0:00 - Introduction
1:17 - Covered Topics
2:17 - Mechanisms of Action
23:09 - Evidence for Glucose Spikes causing Heart Disease
23:19 - Study 291: Oxidative Damage of Glucose Spikes
34:29 - Study 290: Inflammation from Glucose Spikes
42:44 - Study 293: Meta-Analysis of Associative Studies
59:28 - Study 294: Glucose Spikes on Cardiovascular Mortality
1:07:17 - Study 287: Repaglinide vs Glyburide on Atherosclerosis Progression
1:21:55 - Study 292: Nateglinide on Atherosclerosis Progression
1:27:54 - Study 288: Acarbose on Heart Disease Risk
1:39:20 - 2 Risk Factors
1:40:33 - Mid-Point Conclusion/Take Aways
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The information provided in this study analysis is limited to the subject and outcomes detailed in the study analyzed [For example: “Consuming sugar (subject) raises insulin (outcome).”] and is not meant to be an all-encompassing education on every health outcome of the subject (unless otherwise stated). I welcome all respectful critique of the study as I may have missed a key detail that you may catch; if that is the case, I will make an ‘Amendment’ to the video and credit you (thank you for making science knowledge better!). Also be aware that I receive hundreds of UA-cam comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, UA-cam auto-deletes links, so I do not see most comments with links attached.
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#glucosespikes #heartdiseaseprevention #heartdisease
No amendments, currently.
Note: This topic is way more complicated than is often discussed, as you'll hear. If you want a quicker answer, skip to the Take-Aways section, but 0 doubt you'll miss significant context to be more educated on the topic.
Question, why not stop consuming carbs ?
@@longevitycoach1573 The standard answer is that it increases LDL, which many consider "causal". For example, Looking at time index 1:35:0. we can see that in that trial LDL has a p-value of .34. so (sarcastically) we see it is is clearly a significant causal factor as that is much less than .05. Looking at the factors that were actually significant: glucose, hba1c, Trigs, waist circumference, the are generally improved with low-carb, but gotta watch out for that LDL.
@@Dr_Boult well, please let the guru answer, I don’t think you know what you are talking about but I give you an opportunity to prove you are smart as you think, so I have a question for you Why do we get cavities from carbs but not from meat?
@@longevitycoach1573cavities are not 💯 glucose related, there are genetic and environmental factors. I grew up eating tons of sugar straight out of the bag. I have only had a handful of cavities in my 41 years of life. Other my siblings all have had bad dental issues in spite of eating less sugars candies cakes etc. genetically I take from my mom’s side vs my siblings taking from my dads side more. There are also studies that suggest the bacteria that cause cavities can be passed from parent to child by sharing items. There is also research that suggests the same bacteria can initiate the plaques that cause heart disease. If you have any references on carnivores not getting cavities, I’d love to check it out.
UA-cam this case. A us citizen has at the age of 116 years old, has no diseses, no muscular or neurological diseses no alzhimers or dementia. ..110 year old vegan with additive special foot types he adds.
An additional mechanism? (an informed hypothesis)
Blood sugar spikes (among other factors) wash out the vascular endothelial glycocalyx. This is a structure that is not shown in medical textbook illustrations. It is only recently that it has been visualized _in vivo._
The glycocalyx acts as a shield for the endothelial layer. It is also a 'flow sensor' and controls the release of Nitrous Oxide (NO) for BP control (vasodilation).
It takes the glycocalyx multiple hours to recover. With the shields down, the endothelial layer is exposed to toxins, oxidized products and LDL remnants. Continuous consumption of carbohydrates never allows the glycocalyx to fully recover.
It is a one-two punch, a binary explosive. Excess inflammatory factors *WHILE* the shields are down. If you study just one factor, you might miss it (as you clearly stated).
Why would we have such a fragile structure for these mechanisms that protect us?
The flight-or-fight response. "Adrenaline (later, cortisol continues the response) is released which triggers the release of blood sugar (glucose) and fats from temporary storage sites in the body. These nutrients flood into the bloodstream, supplying energy to all parts of the body."
The glycocalyx is washed out, preventing the release of NO and causing blood pressure to rise as heart rate and blood flow increase. That gets the energy and hormones to every nook and cranny of every capillary.
This does increase our exposure to the {toxins}, but _Desperate Times Call for Desperate Measures._
Being in that state chronically (for one example, sleep apnea) is deadly.
thanks for studying the study, and the video!
🤔 Interesting, thanks!
By that explanation, regular exercise would cause the same thing as it raises blood sugar. But, I would like to know that you're not just repeating someone like Cywes and did your own unbiased medical literature research. At what point of blood sugar does the glycocalix get washed out? Why do high carb eating traditional diets end up living longer on average? They're more nuance. Mechanistic does not equal evidence to follow unless there's clinical research to back it up. There's always a million mechanisms going on at once and the benefits might outweigh the cons in practice.
According to the research on the glycocalyx also high LDL-P washes away the glycocalyx. (Tested with LDL injections) Not that you said that this mechanism does not exist, but I think this is important to mention when talking this topic.
Also, it is very much possible that NO production is required for nutrients/blood to get to the tiniest blood vessels, no matter the level of blood pressure because there is a mechanism that closes the tiny blood vessels in sensitive tissues, like in the brain and organs, when high blood pressure is detected. This mechanism is proposed as an explanation for how sodium overload can cause migraine and other issues in some recent studies.
@@ThingsYoudontwanttohear thanks for the further insight!
@@mikafoxx2717 yes. It is all more highly nuanced than we can imagine. These are good questions, I have one to add - does alcohol effect the glycocalyx?
Then to exercise, there is a sweet spot. It is my understanding that highly tuned athlete who constantly runs marathons might not be where we find longevity.
Thanks for making me feel like I understand non-alien physiology more than I actually do. It's a rare ability.
Non-alien is key :)
Taking a 5 minute walk shortly after eating reduces glucose spikes. Eating leafy green vegetables before carbs also reduces the spike.
What did a hungry cave man do when he left his cave early in the morning? Would he grab some grass/grain or berries along his path to the hunting fields? What if a predator was watching him and planned a sneak attack? Would glucose spikes help him to get away? Grab more hanging berries or fruit when he fled from his attacker and found a "safe" place? Ate the food quick before he his opponent approached? Ran away again, then climed a fruit tree with a bird nest? Predator on the ground would leave the place after a while... eggs/chicks and carbs were a late meal that got him drousy but safe in the dark evening?
Bro, what are you even trying to do here? Reason your way out of eating greens?
I literally don't understand how what you said has to do with anything.
@@stigsrnning6459how much kool aid did you drink?
@@stef6682 I prefer any sugary drink over a glass of seed oils. Seed oils are the real culprit of heart disease. See study "Omega-6 vegetable oils as a driver of coronary heart disease"
Literally his Chanel is the best in the health subjects and his videos so understandable and simple ❤❤❤❤
Great video! Many thanks for sharing.
Thank you for explaining these studies
👍 Educating and helping people understand their heath factors.
"From the moment I understood the tendency for my proteins to misinteract... it disgusted me."
I crave the certainty of steel
😂
The Machine does not falter, it does not waver. It is the ultimate precision, the unerring accuracy that we mere mortals can only dream of.
Spike info @1h39min: A semi informative home method is to buy your own glucose meter (cheap at pharmacy) and check glucose levels every 10 to 15 minutes after typical meal. Get a baseline before meal or know you baseline. Your spike should be at about 1 hr and back to normal at 2 hours. Do several times to get a sense of your response. Typical peak for a meal should be around 150 or less. Much higher routinely is not good. My response is good (tested many times) and I am on a high carb plant based diet (complex carbs). HbA1c at 5% plus minus 0.1%. Also, protect your arteries by keeping blood pressure low. Good diet, and exercise, can help here as well.
That gets old very quick. CGMs are a silly gimmick.
@@donwinstondon’t need a Cgm to test your blood sugar.
@@donwinston how are they a silly gimmick?
Who wants a prick a finger multiple times a day to test your reaction to things like cortisol spikes and different foods?
@@valerie4975 If you do not have diabetes they provide little to no benefit other than entertainment.
Really enjoyed this one
This was excellent
A few observations and a question. You take informed approaches to the issues you deal with which means a lot of work, you are clear in your positions without extreme dogmatism as befits a scientist who does not serve corporate interests, you have a sense of humor and I wish you good health. The question is whether someone will have the same results if they consume cocoa beans instead of chocolates
Interesting, what about Cocoa Powder?
Good presentation. On the elevated inflammation markers, you might be interested to know that a study from the Sonnenburg Lab (Stanford) showed that eating fermented foods slightly reduced many inflammatory markers (19 I think). Since chronic inflammation is implicated in aging via many disease states it seems a worthwhile goal to keep chronic markers low, which means healthy glucose levels and if Sonnenburg study is borne out to eat fermented foods.
Not only fermented foods but a whole host of supplements with antioxidants. To mention a few.....Glynac, Nattokinase, Vit E, C, D3, K2, Zinc etc.
Actually, in today's world, 'the more medications you are on, the sicker and sicker you will get'. ....All respect to you, Nick. 😊
Hi, Nicolas. Could you please do a video on Trigonelline? There’s been talk lately that it is effective at raising NAD levels unlike NMN or NR. Thank you and please continue with the great work.
I will be glad to see more proper studies about glucose spikes. Due to a possible pre diabetic state, I adopted a low carb way of eating. It’s been a game changer for me personally . With a CGM I can minimize spikes and watched my A1C drop two points. So I know there is something there…
Hoping there’s an email on this one but maybe a bit too much for one. Like this format.
Good detail, a veritable education.
Sometimes, it's fun to use the word "masticate" in casual conversation. 😛
A woman talking to my ladies' lunch group says:
' I'll just talk while you girls ruminate' 🐄🐮
It's on a spectrum. Obviously, sustained huge spikes are likely to be indicative of other factors that aren't great.
But, at its core, every time you eat carbohydrates there is **some** spike. It's not inherently bad; it's a normal part of the response process to food intake.
Beyond that, I would not extend any sincere concern to the basic physiological response of insulin to food intake. Particularly if, as you mention, you're otherwise healthy and active and eating well.
I like sugar with protein, teriyaki, sweet pickle, pineapple. Maybe a change to mushroom gravy is in order.
At risk of spamming here, but from another post
Blood sugar spikes (among other factors) wash out the vascular endothelial glycocalyx. This is a structure that is not shown in medical textbook illustrations. It is only recently that it has been visualized in vivo.
The glycocalyx acts as a shield for the endothelial layer. It is also a 'flow sensor' and controls the release of Nitrous Oxide (NO) for BP control (vasodilation).
It takes the glycocalyx multiple hours to recover. With the shields down, the endothelial layer is exposed to toxins, oxidized products and LDL remnants. Continuous consumption of carbohydrates never allows the glycocalyx to fully recover.
Spikes *do* matter
Awesome, you fixed the noise \o/
It's just a different microphone. I may try switching it out for my shorter videos and see if that fixes it. I did order a new microphone, though - so, it'll get fixed in the next month.
another thing that's important to note here is the difference between glucose and fructose when it comes to ROS production and mitochondrial overload- the former has many regulatory stopgaps to slow down processes like glycolysis (ex PFK1) in the presence of excess energy, whereas fructose bypasses these safeguards because of where its processing dovetails with glucose metabolism. It's a lot easier to achieve the necessary conditions for mitochondrial overload through fructose consumption than glucose/starch
Sweet nerd-out!
In your reviews, have you ever come across any research studies using Allulose to reduce post cranial glucose spikes?
Listening to your video today, I know someone was complaining about the mic sound, but I would argue that you should set a noise gate on your mic to cut off all sounds that don't fall in your vocal range.
You probably would need to add a low pass filter on top to cut off the unwanted high end frequencies.
I was backing out my driveway when I heard the first thump. Thought "Oh crap! What did I hit?"
VERY well done! I am curious (though I can read the studies to get the answer myself) if they were able to determine how the glycocalyx was affected. I understand that testing can be done to indicate glycocalyx damage. In this case, glycation and wasting of the glycoproteins, which exposes the endothelium to damage.
Thank you so much for the deep dive!
@Physionic what do you think about elite cyclist which consume 60-90g/h of simple sugars and how this can affect vascular health.
Are there any studies pointing toward seed oils (cotton seed, canola oil - rapeseed oils are not truly vegetable oils) playing a part in inflammation with or without glycosolated hemoglobin in contributing to heart disease?
What do think of injectable NAD and are any studies on it?
Excellent first time I stayed for the full event and understood a large amount of it. Here’s my take away….all these trials and drugs to hopefully get to a position that eating correctly would also find the same result.
If only there was a place we could have learnt about nutrition in the early days of our lives🤔
Thanks for watching though - I appreciate it
acute short term studies often bias long term studies in the mainstream medical academia
Supplements?? Time stamp?
sugar spikes also means starch spikes dose it not ? , when ever I eat potatoes rice or corn boom its up all day then when the sugar drops I get so tired.
When I saw the duration, I thought that it's already Friday))
Can you please cover C3G? (cyanidin 3-glucoside)
It's popping up again as a wonder supplement for nutrient partitioning and insulin management, muscle growth.
makes me think about life...
Pushing me toward that CGM Nic….
I just paid out of pocket the information is priceless I have accelerated heart disease pon1 mutation and had to cone out of pocket for a bunch of stuff well worth it
So let me ask you!!!!
My fasting insulin is 3.5, when i eat some fruits with honey my glucose will spike up to 200 in 20-30 mins, then within a 40- 1hr my glucose is back down to 100-105
I keep hearing anything above 180 is bad and is not normal.
My diet is fruit, honey and lean beef.
Because if these spikes its got me worried and now im thinking about going keto.
My question is should i worry about these sharp high spikes even though the area under the curve is low and my fasting insulin is great!
Any input would be greatly appreciated
Cofactors *
For sure! Sugar = oxyded LDL
Berberine is the key!
A husband and wife on their KETO channel, testing sugar substitutes found that only Xylitol spiked their glucose.
CVD is multifactorial. Glugose variability is one of the risk factor, also insuline resistance, high trigleceride, low HDL high blood pressure, Visceral fat. these are all risks factors for CVD linked to metabolic diseases. Now we can mesure the hazard ratio of each of these factor with epidemiology and compare them with other risks factors like to LDL or smoking.
Multifactoral. Sure. But you leave out the causal one. Long-term high ApoB. Tell me you are in a cult without telling me.
Ldl or apob, clearly causal
LDJ cholesterol is the only one that really matters. It is a REQUIREMENT for cardiovascular disease. If it is low enough you will never develop cardiovascular disease NO MATTER WHAT!
@@donwinstonCan you please point me to data that proves nobody with very low LDL gets heart disease? 🙏🏼
@@gavtex1065he can't show that proof... More than half of people suffering heart attacks have normal LDL levels 😮❤ 💔
How frequently should we eat in order to give the system recovery time? Obviously the body is raucous, not operating in a steady state during waking and eating hours.
I heard a long talk by Paul Mason explaining how the damaging component in LDL is the oxidated and glycated. What do you think of this explanation?
He's right, oxidation and glycation are damaging components to LDL. I'm sure he also mentions that all LDL, of all sizes, get oxidized, too... 😉
@@Physionic Yeah, but my theory there is that if you have only a few factors that oxydate and glycate LDL, the body is perfectly able to clear them. And at that point (for ex LMHR) it matters little how much LDL you have, you will have very little or no artherosclerosis. On the other hand, past a certain level of oxidation and glycation, the more LDL you have, the more you get plaque formation. But since most of the general population is either pre-diabetic or anyway has frequent glucose spikes (even just eating bread before everything else in every meal + snacks etc), we observe this causal effect of LDL on CVD.
Just a theory, but for now it seems to explain most of the articles I read on LDL and glucose.
Does this mean that low carb is the only way? Of course not. And other problems can arise from blindly going low carb (seed oils, for one).
At 1:04 in, many confidence intervals are shown that cross unity. I've read that those should be interpretted as not significant. Have I read the wrong information?
For study 292, I noticed there is a lot of variability in many of the stats, especially looking at VCAM and ICAM. Did you notice this? Is this just due to variability among patients, or can it actually challenge some of the findings from the study?
Wait. I though iCAM was Apple's new digital camera.
Close 😛
Just cut simple carbs in your diet as much as possible. Sugar, deserts, most bread, crackers, processed crap food- and you shouldn’t have these spikes. It’s the same advice literally everyone gives. Complex carbs (veggies) = good. Sugar = bad. If you do eat simple carbs - eat them with some protein.
An interesting, very informative , and useful add on to this for you and your viewers is
Gill Carvalho’s (Nutrition Made Simple Channel) You Tube Video Interview with Mario Kratz PHD titled
“Understanding Glucose Spikes|Ft Mario Kratz PHD. “.
One forty-five? Holy moly.
Complex topics need thorough work, not quick fixes :)
Based out the wazoo @@Physionic
...and he could give this talk over 16 hours and still not explain everything. These topics are extremely complicated. I'm always in amazement that he can suss out what to include and what to skip. I would find it daunting! But I'm not very smart, so...
@@Physionic
I've read countries studies, I'm so very tired of old fashioned studies.
Any study that has government money should be required to publish raw data which would allow anyone to in effect do their own studies within a study, even crossing participants from various studies coming up with their own conclusions rather than relying on hire others decided to group people... For example.
You talked about after meal glucose spikes and insulin resistance, but this could also be a sedentary post meal life.
That same person might have less spike if they went walking and that supposed insulin resistance might disappear.
These studies could be better suited for real research if they documented baseline blood work in detail.
At the end of studies rather than looking at results of a group with his and lows and trying to come up with a meaningful average, it would be better to take the individual with the high and back track the details of that one individual to understand why that result occurred.
For example how many people had a sub optimum Thiamine level?
How many outliers in many studies might back track to that cause, or any of various things.
Or as mentioned previously, who did post meal exercise that wasn't documented and would skew results.
The variations in results don't happen by magic but studies the way they are done now don't care, it's valuable lost data.
I guess this is not important if your trying to sell your insulin provoking drug.
And - it’s highly simplified, and I mean with huge respect to Physionic. I don’t know the details, s Chemistry degree is of the tiniest benefit in understanding the complexities of molecular biology. The more I learn the more I realise I don’t know. Analogy - an expert who really knows ( like Physionic) will say at some point A becomes B but there is much more detail that underlies that. To me this is like explaining to an alien how cars are made. “ well we have certain types of rocks and oil. Under certain circumstances these can be transformed into cars”.
Dr Rob Cywes, the The Carb Addiction Doctor explains how in his doctorate research elevated glucose causes endothelial damage. The other compound causing similar endothelial damage is apparently nicotine. Which then, I'd guess, makes vaping equal to smoking in terms of CVD risk? I wonder how high blood glucose compares to nicotine in terms of heart disease risk?
I had a CGM a couple of years ago. I started noticing spikes in BG at times when I wasn't eating. After a bit of analysis and experimentation, I discovered that those spikes were happening when I had a cigarette... So, IMO, the stress response of the nicotine is at the very least one reason why nicotine contributes to CVD.
Does short term glucose spikes from fruit causes blood vessels damage??
Please answer 🙏
I discussed this more in the Insider version, but it's unlikely
@@Physionicso what if we snack fruit through the day and we have short but constantly repeating spikes... :)
PS. I really love bananas...I use them as substitute for sweet :)
@@rn5697it's healthier than other banks you could be eating, so don't worry about it. People eating healthy diets and getting exercise often live well into their 90's, so just focus on doing better and not get overly nitpicky.
@@rn5697, have you ever seen how fructose affects (negatively) the mitochondria? Fructose also depletes cellular energy, amongst a host of other detrimental effects
@@Joe_C. life in moderation?
if you've eliminated prepared sweetened food and HFC's from your diet, then some fruit once a day with it's fiber and nutrients is a win.
OK - Here's a topic you HAVEN'T covered: Both "low carb" ( high protien & fat ) and "low fat" ( high carb ) diets works for weight loss. And I know there is "carb cycling" which uses percentages of each macro. BUT WHAT IF - you ate only carbs one day, fat the next, and protien the next, on rotation. ie. Kind of cycling the polarised weight loss approaches. Carb day would increase insulin high but with no fat to store. Fat day would be low insulin so no fat storage. Protien day would be your non fattening 'meat fix' ... and so on. Would this complete separation of macros help weight loss ???
Is the tail wagging the dog? How about a companion piece asking do insulin spikes cause heart disease?
So what is a spike? 140 mg/dl? 180 mg/dl? 200 mg/dl? I would imagine a lot of these studies have different definitions
Diabetes increases CVD risk.... Insulin Resistance likely also increases CVD risk as well... You are showing inflammation independent of insulin.
Sorry, I went for the overview first. Your choice of studies look good for the purposes of drilling down and look very logical, ending up with the metanalysis. I will look at the papers separately and look at the insider video.
I have seen metanalyses fail before so, I don't have full trust in them, but it looks as if your metanalysis study is rich with a number of studies. What is most important about metanalyses is how they select and discard studies. :)
Hi! I have an intriguing question that is killing me right now. If anyone could answer it, it would be very well appreciated. I recently watched an interview with Dr. Jordan peterson, in some segment of the video, they discussed aboat "peer review" studies they mentioned something on the lines of how people(scientists). Those who do the reviews don't have access to all data/raw data from the studies. They only have access to what the original studies conductor's provide them. Is this true? If this is true. This means our freaking system is massively flawed.
Nick, I’m very surprised that you did not cover the endothelial glycocalyx and the damaging effect of hyperglycemia on the thickness of the glycocalyx. Also you missed that atherosclerosis predominantly occurs in vessels that have high pressure and have turbulence. It doesn’t occur in veins. Disappointing.
Mechanical damage to the glycocalyx explain the above.
I covered what the experts in the field (the researchers in the scientific review mentioned) covered. They didn’t mention it, so I didn’t mention it.
@@Physionic Hi Nick, Thanks for your reply. I'm glad you are looking into this topic. Its a great topic, being the number one cause of death.
Check out Dr Malcolm Kendrick. He is interviewed on UA-cam many times and also has written an excellent book on the causes of CVD. The book is called "The Clot Thickens" and he goes through the evidence for the micro-embolism theory of CVD. It's a bit like a detective story about the culprit of a disease!
How about glucose spikes increase inflammation which increases heart disease (see BaleDoneen Method cardiology)
Did you watch the video? :)
I appreciate the depth of this video. I am still confused about the amount of change needed to be called a spike and what area under the curve is a meaningful change over what time frame. I think this is still in progress but I find this part confusing since I doubt a flat glucose reading is possible or desirable. Thank you!
But how about a myriad of other diseases that it might worsen? It seems like all studies are on heart disease or diabetes.
I mean, they are among the most common, so it makes sense
It's the bacteria that lives in our bloodstream that take calcium to build homes inside your arteries. Bacteria primarily lives off glucose so take glucose away you help with Diabetes/insulin but you also keep bacteria from food sources.
You mean Bacteremia? That's a serious condition that requires immediate medical attention. Otherwise, no humans don't have bacteria in the bloodstream.
For those, like myself, whose horses have left the barn, then you may only have one solution (i.e band aid) available. Extensive self post prandial testing confirmed for me anyway. And, when going low carb (as much as I'd rather not), many symptoms get better (asthma, allergies, palpitations, bloating, mood, tumescence).
Did you try other healthy diets first? Ones equally restrictive of junk food and the like. I've done both and heavily prefer Mediterranean type eating.
@@mikafoxx2717 I think the key is if you have a prediabetic hemoglobin A-1 C then you have insulin resistance and you have to lower these insulin spikes that go along with the glucose spikes first and then I think any heat healthy eating will work toward good health, but first you have to stop the insulin resistance. and low carb seems to do that at least for me also..
@@mikafoxx2717Just curious have you confirmed you don’t have glucose spikes and monitored you average blood sugar per 24 hour period?
@@gavtex1065 You're going to get raised glucose due to the nature of them but if your A1C is normal, your glycation is normal. I exercise and weight lift a lot.
@@mikafoxx2717 I have, and trying again now actually, because I hate low carb :). I did discover that potatoes will raise it to 140, but not the 180-200 that rice/grains do
a good reason to add cinnamon to sweet foods?
or just make them non sweet.
to plain whipping cream add: cocoa powder, cinnamon, and once whipped, a splash of plain kiefer. place on your berries and toasted coconut flakes!
it tastes different, a little astringent, but once sugar is out of your diet for a few days you won't miss it.
@@plumbthumbs9584 how do you make fruit "non sweet"?
@@andrecarvalho1594 fruit and prepared sweet foods are wildly different things. if you're actually interested in an answer, then google is your friend. there is a ton of info out there on the benefits of eating fruit vs sugar / HFC's.
my suggestion is to remove the sugar from whipped cream, add flavorings with health benefits, and serve it over fruit.
@@plumbthumbs9584 my point is that what I said does not imply added sugars
Wow seriously complicated. If only we treated the cause via healthy diet and exercise. 🎉
too much. i need the tl;dr version.
Then skip to it
so, earthling, just what is it you know about the physiology of aliens?...👽🛸
Na-teg-glin-ide?
Glucose intolerant...does this point out to individuals known as * non- secretors* ?!¿...😏🤭🤔
Glucose 'notsees'
Homo sapiens and our closest evolutionary relatives evolved eating a high carb, low fat diet. While high fat diets can improve short-term markers of glycemic control and insulin sensitivity, they may also mask underlying insulin resistance by reducing carbohydrate intake. This means that poor insulin sensitivity might not be directly addressed but rather managed by the diet's restrictive nature.
How have you come to this conclusion, I wonder?
Is it Homo Sapiens being a top predator, exterminating the largest mammals we could find wherever we went?
Is it Homo Erectus, our predecessor hominin, famous for hunting and butchering elephants?
Is it our extreme stomach acidity, similar to that of a vulture?
Is it our short large intensitine and lack of appropriate digestion enzymes, branding us incapable of digesting fiber?
Is it our unique predisposition to produce ketones (by burning fat for fuel)?
That is demonstrably false. Ben Bikman can demonstrate it better than me. Re-adapt to carbs slowly for 1 day and the effect is gone...
I'm gonna challenge you a bit on this, my friend. Do yourself a favor and go into a wilderness area near where you live. Try to find carbohydrates that grow naturally year-round, and are not from humans planting them.
What is your definition of "high-carb, low-fat diet" here? The diet composition for great apes and for peoples like the Hadza is pretty balanced. Chimps and Bonobos eat insects and meat in addition to fruit, seeds/pods, and vegetable matter. Hadza calorie sources are roungly 60/40 plant to animal source on average, including honey in the animal-sourced calories. Don't take my word for it, look it up. But we don't have to eat like our ancestors did and it almost certainly isn't optimal. I eat a whole-food, plant-based diet because I know how and have the resources available to eat that way. I don't eat ants or termites, eggs, or other animals because I don't have to. But let's not pretend that we all *SHOULD* eat HCLF because *ANCESTORS*.
@@OwnYourHealthbyDarius We are a tropical species and plenty of fruit, tubers, and seeds grow year-round where I live.
High PUFA intake, especially with a predominance of omega-6, is generally expected to produce more inflammation and oxidative stress over years compared to a high intake of carbohydrates from fruits, starchy vegetables, and whole grains, for this reason, I still hold the view that replacing PUFA with fiber-rich carbohydrates is a better overall even if spikes of glucose occurs from time to time.
The RAGE pathway. Lol lol
If you don’t know who funded the study, then you don’t know where the money comes from.
Sooooo, ..... that’s a yes , then? 😂
Are you dutch? Verhoeven is a dutch surname
Yes, indeed (or inderdaad as they say in Dutch). I'm pretty sure he is rumored to be the son of the famous Dutch movie director Paul Verhoeven. I agree that this is mostly speculation. We need more data to confirm this hypothesis.
I detect no bitterness in Nic.
This question is regularly asked on this channel.
@k.h.6991 Yes. But is it regularly answered...? .
My N=1 hypothesis is that carbs, sugar, seed oils and frequent meals cause metabolic dysfunction so I eat one meal a day 0 carb carnivore so I’m in a ketogenic state as often as is humanly possible at 58 years young. Will see how it goes.
Probably heart disease like Dr. Akins.
Why are you here if you are following such an anti- science, fad diet?
Glucose goddess has many ideas that will reduce your glucose spikes, without resorting to low carb diet. Low carb diet generally has high saturated fat, that causes high ldl/apob, so that is detrimental
The second sentence is just bullshit.
Can you be sure glucose spikes are detrimental? You do realize that if you eat say 20g of sugar before of after vegetables it is still 20g of sugar? Your body still needs to metabolize it however it ends up in your bloodstream.
Flouncing around in various outfits on a designer set holding a camera at different angles may be appealing to some but I am more interested in the words.
I don't find her anecdotal evidence convincing and certainly wouldn't buy any of the stuff she is pushing.