Reviewing Bryan Johnson Blueprint Supplements - Are They Evidence Based
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- Опубліковано 28 вер 2024
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Timestamps:
00:56 The Longevity Mix
01:28 Calcium Alpha-Ketoglutarate
03:58 Vitamin C
06:30 Creatine Monohydrate
07:32 Magnesium Citrate
09:18 Glucosamine Sulfate
10:15 Taurine
11:08 Glycine
13:17 Glutathione
14:14 Lysine
15:26 Ashwagandha
16:40 Theanine
17:26 Sodium Hyaluronate
18:42 Essential Softgels
19:05 Vitamin K1
21:00 Vitamin K2
22:20 Astaxanthin
23:35 Lutein and Zeaxanthin
24:25 Lycopene
25:06 Essential Capsules
25:41 Nicotinamide Riboside (NR)
26:40 Spermidine
27:37 Lithium
28:15 Rhodiola Rosea
28:30 CoQ10
29:17 NAC+Ginger+Curcumin
29:20 NAC
30:01 Curcumin
30:41 Ginger
31:34 Red Yeast Rice
32:10 Garlic
33:20 My Final Rating for Blueprint Supplements
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Hi Everyone - Bryan Johnson here.
Hey Siim - congratulations on your recent pace of aging score.
A few notes. The blueprint stack is built on population level evidence, not my personal needs.
For your overall score of 3.8/5, I'm going to interpret that as 5/5(!) given that everyone disagrees with everybody about anything health related. I appreciate you not being sensational.
The Blueprint stack is a contender for the best in world. And as you mentioned, we publish third party lab tests and are eagerly learning. We're following the evidence and are working hard to get better. We're trying to make this journey to Don't Die easy for everyone.
Hi Bryan. I appreciate your openness and eagerness to share data. In line with your personal philosophy, do you have any plans to offer Blueprint customers a more personalized approach regarding supplementation based on lab test results, genetics, etc?
@Bryan and Siim. You both are trailblazers! Thanks for all you do.
Hi Bryan, I am Dr.Zeng, MD, PhD. a longevity medical practitioner, and I agree we put a lot of emphasize evidence based medicine but ignored compliance. There are too many ingredients to take at once, I strongly suggest focus on one-drink formulation, I like the idea of only takes one drink and one pill by Novos. I am recruiting people to join the rejuvenation. Olympics by my own protocol.
I Appreciate your Research
@@drzeng1I’m 6’2 will it make me stronger?
Big respect to Siim for being strict with the available evidence and not overselling supplements (and at the same time giving detailed info on the smaller benefits, too).
i feel like he'll have his own supplement line in a few months
@@aneeshprasobhan He already does, just through another company
bryan johnson interview next
Bryan Johnson eulogy next
For what he’s on the wrong
@@PepeCoinManiabryan def has something to lean from sim
aswell as his protocal partner «oliver»
Thank you, Siim, for consolidating the scientific literature on the Blueprint stack’s ingredients into a single video. This was the crucial piece of information I was missing from Bryan Johnson’s venture. Excellent video! 😊
The study showing Spermidine not increasing plasma spermidine was NOT saying it is ineffective, it is suggesting that it breaks down into Spermine which is likely the effective substance in vivo.
Epic video. Great breakdown. Love the format, conclusion slide, and length.
I've thoroughly enjoyed this video. Could you do the same style of video for the NOVOS supplements?
Yeah it's super cool to hear Siim's evaluation of supplemen-stacks !!! Also like to hear his verdict on Brad Stanfields multi-vitamin/mineral product.
@@henrikmadsen2176 that would be interesting too!
Can you do a review on novos products novos core and novos vital
The problem with capsules is that you have limited space to pack in ingredients. I think powder is the way to go if you were creating a longevity product and probably only have capsules for oil based ingredients or ingredients that tend to clump
This. Would be ideal to make a powder that includes as much as possible. Pill fatigue is a real thing.
Been waiting for this!!!
I have been waiting for someone to do this, thank you very much!
Great info Siim, thank you for putting this together in a very simple and fair and professional manner. But man, you go sooo fast😂 I’ll probably need to play this a couple of times to get everything.
You are the best young man! Keep it up your and your beautiful wife are a guiding light for the lost in the pool of supplementation!
Hey Siim, you should do a video on Fred Bisci.. he's in his 90's and he looks so good for his age.. he also still runs and works out! I saw him first on everydaydetox podcast, he has some great guests and info about health!
A lot of it is genetics in such old people. Some smoked all their lives and never ate healthy and reached beyond 100
@@theancientsancients1769 IT's not with him, he eats extremely clean, does lots of fasting, exercise etc
What does he eat? I'll check him out
@@niellalien raw vegan, lots of fasting too, and exercise
One thing that really concerns me about having ashwaganda in his stack is that it’s meant to be cycled and NOT taken daily otherwise its benefits eventually fall off. Surprised Siim didn’t mention this
Damn this dude broke down everything for us for free. This would've taken me hours. Thank you bro. It was a little long and a bit boring but analyzing clinical studies is not really the most entertaining thing.
The issue with all these studies is the following: they examine a substance in isolation, whereas nutrition only works through synergy. It requires the combination of all elements to provide a biological benefit. What bothers me is that the majority of UA-camrs either fall into the trap of repeating the same narrative, losing focus on the fact that a single ingredient can't go far..
That’s why these suplements are worthless
There are some that work in synergy. My point is about the synergy between each ingredient, which published studies do not demonstrate. They always study the ingredient in isolation.
Interesting 🤔 You came to the same conclusion as I have come having researched supplements and cellular health for 20 years. The mix powder has also timing contradictions for some ingredients that increase energy taken with some that are best taken at night for relaxation benefits which in the daytime can make some people sleepy when they need energy. Interestingly there is absence of Omega 3 fish oil or even a vegan algae based one since he is vegan.
Hi just bought his super-phenol cacao powder and can't wait to try it. The promotion that it is very low in heavy metals prompted me to try it.
GREAT BREAKDOWN SIIM. i been taking L Lysine for 20yrs to stop a cold sore outbreak. i take 1500-2000 a day . if i go off this for a week . i get that cold sore tingle and BAM , huge cold sore on my btm lip .also to much L arginine will cause a breakout. i understand not all folks systems will react the same way .
Its alot of info to consume while working but grateful for the rating at the end 🙏🏽
Excellent job Mr Siim 👍
Thanks for the video! Appreciate it! I have been using the supplements for a few months already and I love them! ❤
I really like this video. I was going to give these a miss because I didn't know much about what was in them but seeing this I'll be taking the softgels and the rice
Man I had this open and was looking into glycine as I was on the blueprint page....going back to the video randomly clicking in the timeline and getting to the exact moment when you spoke about it...random matrix moment
What about Berberine
Excellent review
Wow thanks for the detailled review ! I see no methyl donors (TMG/Betaine) taken with NAD Precursors (B3/NR/NMN) am I missing something (maybe he gets enough from his food) ?
If I test this stack I'll probably add 1000 mg of TMG to be safe on the methyl donor side
Brilliant video again. Thank you dr.
I don't think Brian Johnson takes this specific product even though he made it generally for the public for affordability I'm going to look up later if this matches his normal regiment that he's posted online before he made this
Thanks for this review. One note, I think the doses are based on the evidence highlighted by the analysis made on Bryan ‘s person. So there might higher dose whenever the amount supplied by the nutrition appeared to not enough.. and lower doses whenever amount recommended appeared too high for him metabolism. That said, it doesn’t mean this is valid for everyone…
I'd be concerned about many of those in a powder form from a bioavailability standpoint. Most of the research I've read dealing with bioavailability suggest ingredients like CA-AKG, Glutathione, and even Vitamin C, etc., are pretty much wasted once they hit the gut. On the other hand, liposomal forms of AKG, Glutathione - and even vitamin C - all seem to promise far higher biovailability. Also, looking at quantities, seems like at least Creatine Monohydrate and Glycine quantities need to be boosted if targeting populations over 50 yrs old (either that, or older users should be advised to supplement additionally). And as long as Glycine powder is being used, perhaps an equal dose of NAC powder (smell/taste notwithstanding) to aid glutathione synthesis vs. easily degraded glutathione powder? Nice sounding ingredients, just would be concerned about product efficacy from a bioavailability and dosage standpoint - so for me, I'm going to continue purchasing ingredients individually so I can dose more effectively and insure maximized bioavailability. Cheaper in the long run to purchase ingredients individually as well...
blueprint or AG1? or something else? or is there an all-in-one liposomal product?
@@2BWiley2 what about l arginine AKG?
@@nilsobach2659 I’m sorry, I’m not clear what you mean by “blueprint or AG1”. Overall, however, I purchase supplements on an individual basis from different manufacturers only after reading the PubMed or other peer reviewed studies - never on what an influencer or mainstream article recommends. I do, however, follow multiple influencers because informed folks like Siim here are often excellent sources for identifying the latest published research - but I go read that research myself (including any supporting research into bioavailability) before making product purchase decisions. Because I take several dozen supplements daily, my specific purchase decisions are always then based on a combination the following factors; (1) most bioavailable form, (2) manufactured at a Certified GMP facility, (3) third-party lab tested for quality/purity assurance, and (4) lowest price. When it comes to liposomal products, I’m not aware of any “all in one” liposomal products (maybe I just haven’t come across them). You can usually identify liposomal products because most often they are packaged in gel-caps (given their liposomal nature). Hope that helps.
@@graiden Without being able to recall or cite any specifics, everything I’ve ever read about arginine-AKG lead me to dismiss it as a “longevity/wellness” supplement. My understanding of AAKG is that it is intended to function more as a boost to NO2 production (blood flow), and muscle protein synthesis. Those both have their place in overall wellness, but to my understanding there isn’t yet any research with AAKG suggesting a longevity benefit. I take so many other supplements I have to draw the line somewhere and thus don’t personally take AAKG, and so I haven’t looked for research into how bioavailable it is.
From self-experiments I have seen on a forum, AAKG did reduce the epigenetic age, which crawled back after withdrawal.
Great Video as always. Thx for your effort.
Ginger has many other benefits besides lowering inflammation btw
Might've been a little hard on the Essential Cupsules just for the fact that it's a multivitamin? Or was this rated just from the few ingredients that you selected to talk about (5/26)?
Been doing Bryan’s supplement stake for about 3 years now. I don’t remember glycine ever being in his stack. Before he started selling supplements.
Great video Siim
Please also do a review of Dr. Brad Stanfield’s MicroVitamin
What do you think about arginine AKG? It's cheaper.
Actually red yeast rice is just as effective as a statin? I've seen it myself. It's basically a statin. "However, the United States Food and Drug Administration (FDA) have banned these products because levels of the active component are so high that they are classed as “unapproved new drugs.”"
Was very effective for me too. Why take statins when you can take red yeast rice for getting your cholesterol within normal range.
Lowering your cholesterol can shorten your lifespan. I wouldn't do statins. Just cut the carbs.
Thank you Siim for the video. So the 2 bottles that you rated lowest, is recommend to take 3 pills not 1. Should I presume I just multiply what you said about those bottles by 3 then to meet the standards you mentioned that were not enough. I do wish it was less pills because it mean taking 8 pills plus the powder drink per day. I know everything is still new, but cant wait for the day where we can take 1 pill and get all the vitamins we need lol😅
I don’t care for the addition of ashwaghanda and KSM 66 is a very potent extract. I don’t think it needs to be dosed daily and many have reported anhedonia and other side effects from daily use. Take l-theanine out of the longevity formula as well and use as needed.
Everyone uses the argument of "most people are deficient in magnesium" but if we are watching these videos or following Bryan we most certainly ingest plenty of magnesium because we already take care of our diets. Is there any positive evidence for excess Mg?
Great video!!
Why does Bryan use "ASCORBIC ACID" instead of natural source of vitamin C ?? (Dr. Steen Ekberg has an excellent video on the difference)
And why does Bryan use Magnesium CITRATE ?? Everyone else seem to agree that other form are much better (glycinate, or threonate, etc. etc.)
because these are cheaper!
So basically it's not worth it to buy. Long story short, if not this supplement stack? What is a good alternative? Any suggestions
Very helpful thank you
Should test all the supplements for impurities
Good video! 😊
A big question I have is whether there supplements missing that should have been included. For example Tru Niagen
What about the nutty pudding?
Underdesk treadmill, nice,
Is there another supplement stack you've seen that you would recommend above this one?
You should take into consideration that this supplement stack is ment to be paired with his Super Veggie and Nutty putting which might make up for some of the nutrients that you mentioned are underdosed, like magnesium. Additional to the stack he also takes 25g of collagen powder, which is high in glycine and also 1800mg more of NAC. Also an additional 450mg of NR (or 500mg of NMN) and 2,4g of kyolic garlic.
Hi how about omega 3 ???
Slim you know we have NAD pathway right? l theanine is like EGCG help with NNMT not some bs sleep etc
I think people are too obsessed with these "longevity" mixes. Are you really planing to take this till end of you days ? Also all of these evidences are changing every decade. My recipe is - sleep well, eat healthy, exercise regularly, drink lot of water, have good relationships, read a lot, learn new stuff, no stress and enjoy the life. That's it.
having science based evidence is not what makes an ingrediant effective for use. How do you imagine scientists decide which ingredients to research in the first place?
Anyone who wants to be on the cutting edge, should be willing to make inferrences from the secondary data.
Question for Siim or anyone: Does 400mg of magnesium glycinate or the Jarrow B-Right (B complex) provide any significant amounts of glycine or methyl groups. (Searched this and found nothing definitive).
What's your view on creatine being linked to increased DHT / causing or worsening hairless and thinning? I'm really tempted to take it but slightly worried about that
I took creatine for a period. And looking back, I believe it caused me quite of bit of hair loss and thinning. I want to take creatine again, but I don't want to get any more hair loss.
@@shahrikamin4699 thx for your reply! sorry to hear that.. are you on and hair loss medication?
@@shahrikamin4699 thx for your reply! sorry to hear that.. are you on and hair loss medication?
@@shahrikamin4699 sorry to hear that 🫠 are you on any hair loss meds?
I give it 2 stars
I know $40 for some cacao powder is pretttttyy sketchy
Can you review (ALL IN ONE VITAL) and can you review (YOUNGEVITY TANGY TANGERINE 2.0) that would be awesome 👍
Excellent and objective.
Did antioxidants reduce muscle strength or just hypertrophy and if hypertrophy, was it sarcoplasmic?
Why so many amino acids when you can just eat protein?
Its supplement industry! Buy as much as you can and live longer right? lol
5:05 girl smiling while eating a banana
AG 1 is sh*t but i HOPE the Blueprint has a high-quality and good bioavailability.
The big question I always have is: Does a healthy person who eats a balanced and healthy diet need to take ANY supplements? What is the point if you're not deficient? Would love to see a video on this topic.
depends on your goals. Do you Need to take anything, if you eat healthy, and are happy with the life you will have, and how old you will become? No, but you do need to take supplements if your goal is to reach even more optimal health, and you're testing everything to make sure that it's still useful. 99% of the population doesn't care enough to Need to do those things, some are even happy with becoming 50 years old and having lived a relatively happy and pain-free life, so it all depends on the person and what outcomes they want.
blueprint or AG1? or something else?
Def not AG1. I've done both. Liver enzymes shot up on AG1. Been taking Blueprint for a couple of months and feeling fantastic, crushing weights in the gym and VO2 max is all time high.
AG1 contains ashwagandha and green tea extract, the usual suspects.
@@thomasmuller1850 What's wrong with green tea extract? I was considering getting some
@@GrandmasterFerg It was involved in suspiciously many cases of liver damage from supplements.
Just use regular green tea.
Why is he contradicting himself in terms of creative dosage….listen to his creatine vlog…beware of any study…he is cherry picking…
Bryan's dosage would be even more below the optimal dose I mentioned in my creatine video. The 100 mg/kg/day appears to be the optimal dose but 2-3 grams is already effective although less so
Taking that many supplements might reduce your lifespan, but there are unlimited possible negative interactions between them. This nonsense has to stop already, and we should start investing in real interventions that might cure aging
If he needs 100 supplements then his diet is shit
His diet is generally adequate, (whole food, lots of fresh veggies), albeit repetitive. However, despite having a good diet, certain beneficial molecules might require higher doses than achievable through dietary intake, hence the consideration for supplementation.
@@Botanifiles in other words his diet sucks. He is a pilleater.
@@NewDarkKnight dave pascoe takes a lot of supplement too and his diet seems pretty fine
@@captainnoyaux slim takes a lot less supps. There few person in longevity olympics list slim mentioned takes very few supps. I think supps are overrated.
@@NewDarkKnight yep supplements are overrated, they are here to optimize your health. If you don't have the 3 great pillars already (sleep/nutrition/sport) they are a waste of money. They get more interesting the older you get though and that's why Siim doesn't need much, he is still young compared to Dave pascoe or Bryan Johnson
FIRST
34 min video for something that could be summarize in a table. 😅
I don't think you will understand and process all the information of the studies he explain with just a table...
@siimLand i cant find the supplements list in your page
Timestamps:
00:56 The Longevity Mix
01:28 Calcium Alpha-Ketoglutarate
03:58 Vitamin C
06:30 Creatine Monohydrate
07:32 Magnesium Citrate
09:18 Glucosamine Sulfate
10:15 Taurine
11:08 Glycine
13:17 Glutathione
14:14 Lysine
15:26 Ashwagandha
16:40 Theanine
17:26 Sodium Hyaluronate
18:42 Essential Softgels
19:05 Vitamin K1
21:00 Vitamin K2
22:20 Astaxanthin
23:35 Lutein and Zeaxanthin
24:25 Lycopene
25:06 Essential Capsules
25:41 Nicotinamide Riboside (NR)
26:40 Spermidine
27:37 Lithium
28:15 Rhodiola Rosea
28:30 CoQ10
29:17 NAC+Ginger+Curcumin
29:20 NAC
30:01 Curcumin
30:41 Ginger
31:34 Red Yeast Rice
32:10 Garlic
33:20 My Final Rating for Blueprint Supplements
No Need to Watch to know that it's gonna be a video full of useful info as always. Thanks siim
blueprint or AG1? or something else?
Wt about olive oil? Is it worth that much money?
@@saishreyas5057 I don't think so. You can just buy the olive polyphenols extracted from the leaves instead. I am allergic, though. I can't have either. Lots of other polyphenols out there, though.
I get auras without the migraine (silent migraine) if I take the olive leaf pill, or if I have nacho flavored popcorn salt. Practically makes me blind for a few hours, while I watch a color cycling fractal light display. Pretty scary first time. I had to Google for hours to figure it out. The vast majority of the time people see auras, they have a killer migraine that can be so intense they throw up. I guess I am lucky. Except for not knowing what the heck was happening. First time it happened in college. Went to the nurse. She kept asking what drugs I was taking. No. No drugs! Only after the second time did I deduce it was the nacho flavored salt on my popcorn. Half my diet was popcorn. A student government card allowed me to have unlimited popcorn, and I was there all day generally, so lots of popcorn.
Never had enough green olive oil for that reaction. It feels like I am swallowing a mouth full of shattered fiberglass...so it never got that far. I can have the low end, yellow stuff. Probably little benefit from that. Mostly I use avocado oil, or flaxseed oil.
Sticky this please
Siim neglected to mention that Astaxanthin extended mouse longevity in the NIH ITP trial, the only antioxidant ever to do so.
Good point! And what about this - my personal speculation: Antioxidants once was the 'end all be all', but then they found that too much antioxidants (eg. beta-carotene, and vitamin E) is actually harmful. This led to the current belief that "balance" is the important thing. Why, then, would Astaxanthin be good for us - as Astaxanthin is a much more powerful antioxidant than vitamin E !!??
We aren’t mice’s
The studies made on mouse are t valid for human beings
This is the exact video I wanted from you when I first found your channel a month ago. Thank you.
General wish: I wish ALL health-content-creators could refrain from saying "The improvement is SIGNIFICANT".
Do this instead - always:
· Say HOW LARGE the increase/decrease was !!
· And then maybe tell if that result was STATISTICALLY significant.
· And then give a personal valuation of the result.
[all too often "significant" is confused with "a lot"]
That said ... I always press "like" to Siim's videos, even before watching hehe 🙂
Given variability from person to person and from a 30 year old to a 60 year old, I would argue the science you are looking for is at best an approximation.
Spoiler: the improvements from these supplements were minimal at best.
@@Scottlp2 It was more a 'general ask' when youtubers present findings from scientific studies (they always have a 'result' and a evaluation of the 'statistical significance' of that result)
@@CrissmanLoomis In any case, I wish they would ALWAYS inform us 'The Results' (the actual level) - and maybe the evaluation of 'statistical significance' of those results.
Unbelievable quality, thank you
Maybe the dosage a bit low on many supplements compared to studies, could be due to the fact that the effects of blueprint appears more or less after 2-3 months;
Maybe your body need to accomodate and taking it everyday for 2-3 months contribute to a higher amount in your blood compared to what the studies generally monitor in term of duration. just an hypothesis.
personnally as a former soldier , now managing big state projects, I always did some sport routine with cardio and musculation.
-generally 20 min musculation early in the morning,
- then shower and fresh bath, for anti depressive effect
-then 20 min bicycle (at maximum speed for hearth) to go to work (the same to go back at the end lf the day).
if I feel a bit tired I take 1-2 days stop in the week, or with only musculation or bicycle.
I add :
- hemp fiber supplements (because I don’t eat enough vegetables and fruits)
- antioxydants
- some d3 vitamins sometimes (30% time)
- magnesium sometimes (30% time)
in France we don’t need chocolate and oil supplements, we got it everywhere with quality and cheap
i always slept well (8-9 hours a night, without any problem) and I take a 20 min break at work after a very light meal (sardine box, banana…)
I try to reduce my eat meal of 15% because of studies showing 2-5% slowing age
now the bad things I do and try to improve :
-Mcdonald or fast food (1-2 times by week)
-party generally on friday night, with sometimes too much alcool which kill my saturday routine, and need to go back on sunday with difficulties and stress.
nobodys is perfect, and I am reducing bad habits regularly but slowly.
i also have the chance to been born in one of the healthier place in france (Cantal) and My family live very long (more than 100 years, and my parents look 10 years younger without doing anything , and not much sport) so this is encouraging
Love this channel
Try black garlic which is fermented in a way
Magnesium Sh*trate! haha
i'm part of blueprint 5k (first batch to test the product for 3 months prior to release) and it's evolved quite a bit. lot of side effects from the nutty pudding for many
What were the NP side effects ?
I don't really get how there are side effects from food? I eat NP but make it from scratch buying all the ingredients individually. Its my favourite meal of the day. I wouldn't bother with the packet version cause the fresh version tastes so good , you can literally feel the nutrients as you eat it.
@@GraftonPrimaryvideo
where do you buy each stuff ? Do you have links ?
I don’t make it into a pudding but mix it with milk for a protein shake
About glucosamine, some possible side effects,.if you are vulnerable, are: raising eye pressure and higher HBA1C.
🤣 16:55 This guy is mad as hell! Probably spent all his money on supplements and wish they were cheaper.
When I think of longevity, I think of pink powder and food in bags.
Random as* controlled trials?
29:15 400mg of a Ginger monkaS
too expensive for me :( im from a poor country
30:49 caught me off guard 😂
Trimethyglycine and hyaluronic acid don’t seem to be present?
He personally takes 1.8g NAC upon waking and 1.8g NAC at 11am, perhaps he reduced it for his commercial product
Id like to raise an important point
1) the longevity mix might not necessarily have clinical trial level dosage for all ingredients (say, Magnesium) since he would also get some of it from his (beans/leafy-greens for Magnesium) meals !
I am really interested in these supplements but since they‘re really expensive I am asking myself do you really need these supplements?
I already eat a balanced diet (eggs, meet, fruit, vegetables, nuts, tea, etc.) … would it really benefit me or just be a waste of money?
Thank you as Always Siim !! And Hello to you Bryan ! Thank you Both
🇺🇸♥️🕊💪🇺🇸
Can you rate other supplements of big companies please. Already done athletic greens?
You gave the supplements 4 stars even though they're cheap versions and low doses?