New lifespan study: link.springer.com/article/10.1007/s11357-023-01011-0 💊 MicroVitamin (multivitamin & mineral that I take): drstanfield.com/products/microvitamin 📜 Roadmap - how to look young & feel strong: drstanfield.com/pages/roadmap
You don't find it weird that you talk about a new finding every few days that somehow magically extends life by 10%? How can so many different things have such a big impact on longevity? There are mistakes being made somewhere. There is zero chance that any of these things are extending life that much. Imagine thinking you can stack a few products and magically extend your life by 50% lol.
Hey Brad, you are looking week by week older and older, weaker and weaker...what's going on? Should I send our nutrition and supplementation protocol? We never get ill (even not a little bit) since decades and looking decades younger. 😊
Can vitamin B9(folate/L-5-MTHF), B3, B12, ZINC, vit A, vit C, vit D, Quercetin Which of these supplements be taken in conditions like too much urination and UTI? @DrBradStanfield
@@TurKishsoulja It's all a matter of healthy living. Huge studies, the past few years, involving close to a million people, show multiple cups of coffee a day extend life. We're talking an extra 5 to 10 years. And this was first shown in the 18th century. Point is,.. coffee is loaded with antioxidants. If you eat right, get all your nutrients you'll live longer. Unfortunately, as we age, we need to get help with nutrients through supplementation.
So I had severe arthritis for ever, tried everything, then began with Astaxanthin, after 2 weeks of 24mg per day, the arthritis almost disappeared, that was 6 years ago. I recommend it to all my friends of age 50 plus. Even my doctor wanted to know how I did it. Life changing.
@espenforfen, good day. Can you be so kind to advise which astaxanthin product you used to achieve your results? It will be great to know nd I'd be very grateful.
I have not tried Astaxanthin yet, but I thank you for this testimony. Last but not least, very happy to read that it killed your severe arthritis in a bunch of weeks ☺
I think you are ignoring the basic results....astaxanthin extends lifespan in yeast, worms and mice. NIH ITP study of mice lifespan shows 12% life extension in mice. As good as rapamycin alone for the same test protocol, which has only identified about 4 items with 10% plus life extension.. The vitamin E and most other antioxidants have not been shown to extend lifespan. IMO, this implies that astaxanthin has some other significant mechanism of action besides acting as an antioxidant to extend lifespan. Furthermore, it is very safe, so anyone wanting to extend lifespan with minimal risk would be foolish not to consider astaxanthin. If you want to wait for life extension protocols that are fully proven, you will be dead before that happens...life and success are all about caclulated risks.
quite possibly. My point is that before getting too carried away with the results, I'd prefer to have more trials in humans. Particularly since NO ANTIOXIDANT supplement has been shown to offer benefits for otherwise healthy people (as per that Cochrane review, and multiple reviews since then)
@DrBradStanfield NDGA is one of the 4 ITP identified molecules shdown to give 10% plus life extension in males, and us a powerful Antioxidant in it's own right. Also, don't ignore the fact that astaxanthin is a powerful Antioxidant in BOTH aqueous and fat, AND, is one of only a few antioxidants which can operate inside the mitochondria... I think these observations show the possibility that astaxanthin, even as an antioxidant, may have fundamental mechanisms beyond almost all others. Although desirable. I don't think we need to know the exact mechanism for how something works to take advantage of it after a risk/benefit analysis. Not everyone is around 30 years old as you are... I think risk benefit analysis would say anyone over 40 should almost certainly take astaxanthin.
Thank you for reviewing the studies on Astaxanthin since there weren't many video reviewing it for the last decade. I started taking 12mg daily 11 years ago (when I was 33) after getting some bad sunburns on glacier climbs. I was already taking turmeric and eating lots of frozen wild blueberries and wanted to try a supplement to reduce the risk of sunburns on long bike rides in California. I haven't had a bad sunburn since I started taking Astaxanthin and my skin seems to have aged less than my half-brother who is 9 years younger. Another side benefit of taking Astaxanthin for 11 years is that I appear to be somewhat tan year-round even in cloudy Seattle. If it's enough to turn farmed salmon from grey to pink, it is likely doing that to my muscles and fat as well but at least the whites of my eyes are still white.
I was taking Astaxanthin for 16 years in itd best form. Skin wise it helped i think specially in the sun i never used sunscreen. Antioxidant wise it refreshed me after poor sleep
Astaxanthin has another effect on longevity that isn't commonly known. When studies were done on centenarians (people who live over 100 years of age), they found that many of them produced a very specific variant of FOX03. This specific variant seemed to have all kinds of health benefits from keeping immune systems strong, to cognition. It seemed like a good puzzle piece for why centenarians seem to not only live long, but with good health until their deaths. The trouble is that most people do not produce that specific variant of FOX03... it was found that astaxanthin can actually promote production of that longevity FOX03 variant, essentially mimicking the increased expression that centenarians have. That is why I started taking it (my DNA test unfortunately revealed that I don't have the longevity version of the gene). I think this may be another reason it shows 12% increase in lifespan, not just from a NRF2 standpoint.
About that at ScienceDaily: "Astaxanthin compound found to switch on the FOX03 'Longevity Gene' in mice" An Astaxanthin compound has been found to switch on the FOX03 'Longevity Gene' in a study using mice. Researchers measured a nearly 90% increase in the activation of the gene in the animals' heart tissue. I couldn't see any disclosure from the authors. I suspect they have some non-diclosed company interests.
@@bigguy130 I think there is a balance where too much is not good. A lot of antioxidant effects and even NRF2 activation might make someone feel good and reduce inflammation, but it doesn't always fix underlying issues and might even increase susceptibility for infection by removing the immunity “weapons” from the IFN-gamma cascade. For example, NRF2 has been shown to reduce pro-inflammatory cytokines like IL‐1β, IL‐6, TNF‐α and IL‐18 (not always a good thing), which can reduce immunity, and also down regulates production of NLRP3 inflammasome which is important in fighting infections (study reference: "NLRP3 Inflammasome-A Key Player in Antiviral Responses"). Another study looked at the reduction in immunity to fungal infection due to NRF2. Likewise in cancer, NRF2 inhibition may be important (study reference: "Nrf2 in cancers: A double‐edged sword". You can check out a 2021 publication that has references to many other studies on the matter ("Smoking‐aggravated oral candidiasis: Nrf2 pathway dampens NLRP3 inflammasome"). Another thing I'm considering is that astaxanthin builds up in the system like other carotenoids, so I think a lower dose over time is more prudent. For example, I take 4 krill oil gel caps with astaxanthin in it every morning with eggs (Kirkland brand from Costco), and that that is about 750 mcg per cap (total of 3 mg a day), and I eat salmon once a week too. This is just my opinion, but it is more intuitive to me to get high amounts in the "high range" of what a diet might provide simply because of the negative issues with too much NRF2 and antioxidants. I think 16 mg from a dedicated supplement might be in dangerous territory over time (as it accumulates).
@@larsnystrom6698 The National Institute of Health (NIH) partly funded the study, and I tend to think government collaborated studies tend to have less agendas. Dr. Bradley Wilcox was the principle investigator from the NIH, and he is quite reputable from what I have read. Copied: "Dr. Bradley Willcox, MD, Professor and Director of Research at the Department of Geriatric Medicine, JABSOM, and Principal Investigator of the National Institutes of Health-funded Kuakini Hawaii Lifespan and Healthspan Studies."
Yes…I started taking 4mg almost daily about 5 yrs ago since my eyesight was getting bad..to the point I had to have trifocals…after about a year I hardly need any glasses…I can read and see well..in fact not wearing any now and no issues writing this or watching the TV..I would also have an issue where twice a year or so I would end up with a sore knee or knees that is gone now also…and also noticed my skin looks healthy and I don’t burn easily in the sun anymore..anywoo that is my story.
@@dom2484 I take Bio Astin from Hawaii..it’s not expensive and have had zero issues…while some will say to take 12 mg based on research ..I’ve found that just 4 a day after a meal is fine for my issues of eyesight and joint pain and skin…
I've been taking it for about 9 years now. I still look the same. It probably has helped stop wrinkles and skin damage as well as many other benefits that aren't immediately apparent
Good detail in your video . I saw that Japanese researchers have helped patienrs with heart and liver problems with 12 mg doses of astaxanthin . Their x-rays showed reversal of probably fibrosis , which is significant . Studies report that astaxanthin stops or slows TNF beta 1 , which is essential for fibrosis .
I agree more research is needed for astaxanthin as a supplement. I am taking Glycine and NAC which has made a huge difference to my asthma and lung function overall. As a licensed aesthetician we have known the antioxidant benefits of astaxanthin in skin care products for quite awhile and you will find it included in many well researched brands. Try to find it in liposomal form for increased penetration paired with other great antioxidants such as Ubiquinone, Glutathione and Ergothioneine.
Topical astaxanthin is an underexplored agent. As far as properties I like that it it can distribute in both hydrophobic and hydrophilic spaces as well as localize to the mitochondria. But the ITP is what really counts, theory can only take you so far. Now it's time to test in humans. That has already begun and there's a nontrivial amount of work done here before but typically lower doses for specific conditions (and based on animal studies examining certain eye conditions healthy brain aging / neuroprotection, cardiovascular, etc).
Taking glutathione as a supplement is risky as it can easily do more harm than good, resulting in a shorter lifespan. Glutathione is the most potent antioxidant in the body. This potency means that too much in any cell type can do great harm. Your cells regulate their own glutathione level as the amount required varies depending on tissue type, the amount of work the cell is doing, health status, etc. There is no single, good level for the whole body, at any time. However, glutathione production does decrease with age and in an inflammatory environment, and higher levels are associated with a longer lifespan. Taking into account all of the above, the safest way to boost glutathione is to supplement with components your cells can use to produce it. Among the best of these are Glycine and NAC (particularly glycine). Another is Selenium. Selenium supplementation alone has been shown to increase glutathione levels in tissues, but be careful with the dosage - 200 mcg per day and above has been shown to have negative health effects in some people. 50-100 mcg is probably better for most people. Glycine you can take lots of, as in many grams per day. It is well tolerated in high doses and also has numerous other benefits that help with aging. NAC has also shown good results but mainly when combined with glycine. It mainly helps by providing the sulfur that's required to produce glutathione. Some foods also contain a lot of sulfur, such as eggs, broccoli, cabbage, brussels sprouts (most smelly greens). Consuming any of these while supplementing with glycine should have a similar effect to taking NAC.
@@DrBradStanfieldHello sir. I have learnt chemical sunscreens are ineffective against photoaging caused by blue light emitted from mobile phones and monitors. Only mineral sunscreens protects from blue light. Shouldn't we be using mineral sunscreens provided that we are spending more time in front os screen rather than sun now a days.
What's not mentioned is Astaxanthin's ability to start a proliferation of stem cells and increase their potency in the body which I would assume would extend life.
Apparently, moringa is just as good at activating Nrf2 as sulforaphane and is much easier to consume than broccoli sprouts. (Source: Jed Fahey in Rhonda Patrick's interview). Also, it is way cheaper than Astaxanthin, and, reportedly, helps with blood sugar.
Yes, although we are lacking well powered, randomized controlled trials to make any definitive conclusions about benefits and risks. Personally, I don’t supplement with Moringa
Moringa powder can be purified but depends on the source. I am not endorsing any particular product (or substance for that matter) but generally speaking I personally (and others may find helpful) subscribe to ConsumerLabs. There is a membership fee, but they do third party testing of common consumables. I personally try to mitigate my exposure to heavy metals by sourcing my food carefully. Independent testing by unaffiliated auditors (certificate of purity) is something I value.
This molecule evolved for one purpose only- protection from solar radiation, that sounds like something that would benefit humans. I mainlu take it for eye and skin health. As an airline pilot I also am exposed to more solar radiation than most. I had a dermatologist tell me that she sees a lot of pilots.
Take higher dose in the summer to prevent sunburns because I dont like sunscreens. It really does help. Take it for years and got perfect skin and no wrinkles.
One of the scientist that worked on that mentioned this supplement was considered because it was an M tor inhibitor like rapamyacin. I think that is actually the cause of the lifespan extension, not the antioxidant part.
it under the unpublished section of the interview. he also mentions bonine is a stronger mtor inhibitor than astaxanthin but I wouldn't take it because it lowers acetylcholine in the brain, it is an inhibitor, which would decrease brain health which would lead to quicker deterioration of the brain. @@viracocha2021
Yup. I take 10mg Astaxanthin at least 5 times a week. I also divide a 10mg caplet among my 3 cats once a week. IMHO all diseases begin as inflammation. Suppress inflammation!
@abc_cba It comes in various types, so to speak, but I've found that capsules with BROWN COLORED *POWDER* are the best. It's water soluble so I just pull a capsule apart & sprinkle it over their wet food, e.g. Friskies.
Hello, Dr. Stanfield. This is easily my favorite supplement. I have been taking 12 mg daily for years. I will publish a video on astaxanthin in the next few days. I am almost done with the script. You made a huge mistake in your explanation that astaxanthin can harm the balance between oxidants and antioxidants. That's not true. I will provide absolute proof of this in my video. All the best to you!
Thanks. Looking forward to your video. I’m curious to hear your explanation as to why astaxanthin, via its NRF2 activation, can’t disrupt the balance between oxidants and antioxidants (particularly after exercise)? Also interested in the human research you present. From the meta-analyses that I present in the video, from what I can see we lack robust data
I look forward to checking it out. I've posted my "quick and dirty" on the ITP through lense of aging biology research. I find interesting to see how different science communicators prioritize different aspects of the science. I could spend over an hour discussing the study but that's too much for the general listener. So I pick and choose, and we're all picking and choosing differently.
@@DrBradStanfield Dr. Stanfield, I made the video. Actually, I made two different videos on it. I am sorry, but I just saw this comment. You will see that astaxanthin is in an entirely different category of antioxidants. It does not disturb the balance between oxidants and antioxidants at all.
They used a really high dosage of Astaxanthin for the mice, 1840 ppm in their food, for the life extension study. Using the rule of three several times or just the rule of thumb, 1ppm ≙ 1/7 mg/kg mouse body weight, that's 263 mg/kg mouse body weight. Or around 21mg/kg human body weight. Or about 1.2 g for a 60 kg human. That's unfeasible for anyone's wallet.
It is expensive and less tested at those kind of doses. The ITP has not tested at lesser doses so it will be interesting to see the dose response curve on efficacy in mice. Not the same as human data but may be some indication whether the small doses in conventional OTC are worth the premium. Of course, I coach in longevity medicine so you must imagine I'm willing to spend a great deal (by %) on products I believe are valuable.
@@JohnnyMagorish maybe a "Minion" or for those of us who remember (dating myself) perhaps a muppet! In all seriousness I think Brad takes on a challenging role which is offering people suggestions when data is early / preliminary. Different folks will make different choices (whether, and how much, each with their own risk/benefit profile but an elusive one since so little data available particularly on the efficacy side).
if you take the precursor of sulforaphane, glucorophanin and take a myrosinase enzyme with that such as adding a seasoning of ground brown mustard seed to your broccoli or taking it in a cap, surely this gets around the instability issue of sulforaphane. Many sulforaphane supplements come as that combination rather than in the form of sulforaphane.
I take Astaxanthin for some time now to recover from multiple tendon issues and it works great for me. However as soon as the tendon issues have fully healed I want to phase it out.
Thank you for this interesting video and your thorough research, as always! 😊 I'm under 60, but I would like to know if makes sense to take oral astaxantin for UV protection. I use sunscreen every day, even in winter (central Europe). However, I thought since UV radiation in my region is not so strong in winter, I thought it might be better for the skin to avoid too much creaming, let it regulate its moisture itself and take oral sun protection instead. (In summer, I always use sunscreen.) What's your opinion on this? Thanks in advance!
I'm over 60 and have decided to take astaxanthin intermittently, like one month on, and one month off, or perhaps two or three months off. The idea being to get some repair work done without being constantly soaked in antioxidants, for the reasons Dr. Stanfield explains.
This is about protein, Mische PHD (youtuber) went over a recent meta-analysis of protein use in older people that found no statistically significant difference between people who got low to RDA recommended protein and elderly people who got significantly more protein. It seems that in real world testing, protein may not be very helpful for the elderly. Exercise is far more important. Trying to cram in so much protein can also lower important hormones like testosterone. With that in mind, I'll be sticking to around RDA levels of protein. Thanks for all your work, I have learned a lot from your videos!
protein is good to develop muscle more quickly. Exercise is both necessary to develop that muscle and good for health. You can skip the first one if you aren't in a hurry
Uric acid medicine has been taken by the world's oldest living man and his diet is customized to reduce uric acid in his body. Allopurinol is a popular medicine to reduce uric acid and has been shown to extend life. What do you think about allopurinol and medicine to reduce uric acid?
When talking about anti-oxidants, a key point is whether they actually reach the mitochondria where a lot of the oxidative stress starts. There might be more, but I am only aware of two - Glutathione, and Ergothioneine. I hadn't heard of Astaxanthin reaching these locations (and I am 99% sure Beta-carotin and vitamin E don't), but I was under the impression that it crosses the blood-brain barrier. I personally think that everybody should add supplements for ergothioneine twice a month. But don't buy a pill - get a carton of mushrooms.
Astaxanthin is a xanthophyll carotenoid that has been shown to have antioxidant properties and may prevent mitochondrial dysfunction by permeating the cell membrane and co-localizing within mitochondria. It has been suggested that astaxanthin can neutralize free radicals in mitochondrial membranes, resulting in an increase in cellular energy production. Astaxanthin has also been shown to maintain mitochondrial integrity and prevent oxidative stress. Therefore, it is possible that astaxanthin reaches the mitochondria and has a positive effect on mitochondrial function. (check Bing AI to see the full excerpt with links)
Hydrogen Rich Water is shown to reach mitochondria and specifically target the toxic oxidative stress but not the oxidative stress required for basic functions.
I eat blueberries daily for the last 5 years with polish kefir and walnuts / almonds and olive oil Exercise daily Eat collagen peptides daily for the last 4 years and Haluronic Acid as funny as this might sound but I barely have any wrinkles (I'm 41)
I'm 40, smoked from 13 years of age to 39, been drinking lots of alcohol, eating poor food, bad sleep, no exercising, and I spend a lot of time in the sun during summer.. and, I have no wrinkles.
Great video thanks. I have a question. I learned from you seems that I shall not take antioxidant supplements before or during weightlifting training. But how about right after training? Can I or how long I have to wait before taking antioxidant supplements? Thanks
Do you have any theory why betacarotene in blood is one of the biggest predictors of longevity (even in a dose dependant correlation 10.1093/ajcn/nqy097) but betacarotene supplementation is not? Is it possible that eating the plant instead of the supplement is helping us somehow?
💎Astaxanthin is a potent 5-Alpha-Reductase Inhibitor (Like Finesteride), and as such, can cause symptoms similar to the side effects seen with Finesteride: This condition, termed post-finasteride syndrome (PFS) is characterized by sexual side effects (i.e., low libido, erectile dysfunction, decreased arousal and difficulty in achieving orgasm), depression, anxiety and cognitive complaints that are still present despite drug withdrawal 🔴🔴🔴 (Diviccaro et al., 2020).
The dose makes the poison. I am aware of no quality data in humans at the doses in OTC meds. Having said that, to your point, no quality evidence (or any for that matter) on lifespan in humans though some small condition-specific trials.
I'm currently on Finasteride and I would appreciate your response here. Can I take Astaxanthin as well? I'm highly interested because of the research I have done so far sounds very attractive. However I am a little confused Some research talk about increase in sperm and testosterone levels. Whilst some others talk about erectile dysfunction and lower libido and breast growth in men. Thanks for taking the time to get back if possible.😊
Is the 12% figure for the whole population or for the male mice only? Because if it's for the whole population and female mice weren't affected, then it's like a 24% increase in lifespan in male mice and this is huge. Those of us who are male mice would like to know!
Dr Brad I really like your videos. But i want to point out that I remember there was a study saying that taking beta carotene in supplement form as opposed to getting in food was harmful, not when you get it in foods that have other natural vitamins and things along with beta carotene that work together in a beneficial way. I also remember a study correlating high carotenoid levels with health and longevity. I have been taking 8 to 12 mg of astaxanthin for 90% of the time since 2009 and I am 60 now and I believe it has slowed down the aging process. How do you know for sure the 2 supplements you recomended are safer when there are so many possible effects on other things in the body. Since astaxanthin is found in nature would it not be less likely to have some bad unknown side effects.
It's a bit strange that you reject Astaxanthin because it's an anti-oxidant like Beta-Carotene and Vitamin E, but at the same time endorse NAC, which also is an anti-oxidant and comes with many quite risky side-effects, including cancer. NAC hasn't been shown to increase lifespan, GlyNac only in inbred "black 6" mice with short-lived controls, whereas Astaxanthin did extend life by 12% in three separate cohorts of genetically diverse mice.
He has a thing against antioxidants because oxidants are released during exercise, so he believes they are not that bad. As astaxanthin is one of the most powerful antioxidants in nature, supporting it would mean he is fundamentally wrong. If he is capable of changing his mind he will, but nevertheless he didn't reject it, he only wants more reassurance. You are absolutely right about this being better, and it's present in foods already
great video, thank you. can you please make a video on olive oil. the olive oil is the most debated issue of our days. many experts now are saying no olive oil. only a few Dr. are saying yes to olive oil.. Dr. Greger is against olive oil. a video on PS phosphatylserine willbe great too. i am a 47 year old . i have been a pharmacist for 16 years. PS is the only supplement that has made a difference when it comes to memory and retention of information. i have tried every single. product for 16 years, including the best fish oil ( perque ) nothing come closed to PS for memory. Rhodiola was great, but i got pain in my kidneys. you are taking crestor 5 mg. i was thinking to add it to my regime, but i am afraid of side effect, Diabetes and joint pain. I have eating your perfect meal for over 10 years and my LDL is at 120. it does not want to come down.
Can vitamin B9(folate/L-5-MTHF), B3, B12, ZINC, vit A, vit C, vit D, Quercetin Which of these supplements be taken in conditions like too much urination and UTI? @DrbradStanfield
Hello, Dr. Stanfield. Is there anything helpful to blunt the purported anhedonic effects from NAC? Also, thank you for your perspective and insight into astaxanthin.
Dr. B. Now I came across a different form of NAC. What is your opinion about Augmented NAC. Its expensive $$$. The makers & their studies praise that it neutralizes COVID spike. I may try it for Fibro/Chronic Fatigue Syndrome of 20+ yrs & worsening that may have been induced by EBV? A.K.A. "The Original Long Covid"!
Why do we listen to this man any longer? The videos are titled to lure viewers in but his recommendation are always "we need more studies." If there isn't a Chochrane review that Dr. Standfield can hide behind he'll never have the courage to recommend any supplement in fear of professional consequences at home. There are far better non-doctored experts on nutrition and supplements to be found on UA-cam worthy of ones time who delve far deeper in to the details of medical literature than simply summarizing meta-analyses.
Well said! Additionally, I strongly suspect he is working for Big Pharma to discourage people from taking supplements, so they remain dependent on prescription drugs.
At first it sounded like astaxanthin did not have the potential drawbacks of other antioxidants, but then... Are you aware that antioxidants in food have positive outcomes in studies as opposed to the typical supplemented ones? I think there's gotta be a way to maximize that benefit from supplementation with the right stuff. I don't want to start delaying aging only at 60. Does astaxanthin only provide the body with additional antioxidant capacity exactly where needed or can it also help to eliminate/reduce the effects of eccess antioxidants, which might arise from conumnption of vitamin A, vitamine E or curcumin?
AFAIK I was the first to post the actual published manuscript on Twitter (When Rich Miller was on Peter Attia's podcast it was just a preprint twinkle in Rich Miller's eye!). Appreciate Brad making the info more widely available, moreover science communication to general audiences.
Thank you for another great presentation. I'm 61 in three months. I do experience inflammation bouts (I eat heathy, primarily carnivore after years of eating healthy foods which contained too many carbs!). Life catches up to the body, after many years in the military and that lifestyle. What would you think (just opinion as I know you are young still and not in my body) would be a good strategy to use an antioxidant, after exercising? Wait several hours for the positive effects of inflammation first, and perhaps then the antioxidant before bed perhaps to gain some adequate rest and get cortisol down? Also, have you done a video on Ean natto Tocotrienols-Vitamin E? I have heard it surpasses the standard, and isn't a risk for cancer etc. Thank again Dr. Brad-you rock!
Have you ever played WoW and it seemed you're just chasing the 'flavor of the month' class? Almost as if Blizzard themselves are making specific classes over-powered on purpose in cycles so folks will re-roll other classes and keep them subscribed. I feel like the supplement industry is doing this with these 'lifespan increasing' 'super-duper awesome' supplements.
Eh IDK about this review. You stated "there are substantial risks" but didn't state those risks in any documentation, you also skipped over the Oxidative stress study which specifically points to significant reductions in MDA etc. Likewise I feel like you focused too much on the "antioxidant" label here rather than the other interesting things Astaxanthin does, specifically around p38 inhibition, MAPK signaling/protein regulation etc. etc. etc.
I’ve heard a concerning side effect in men that Astaxanthin can cause hormonal changes in men who develop Gynecomastia. Could you please comment on this as I am currently taking Astaxanthin but definitely do not want moobs! Thanks!
So many of the longevity supplements that get so much attention seem to fall into the category of anti oxidants. By taking multiple anti oxidants are we being redundant? For example, could we just take Gly-Nac to allow the body to increase glutathione and let that do all of the anti oxidizing? Or, do different anti oxidants neutralize different kinds of oxidants? Also could astaxanthin be a good "hit and run" treatment? (Say high dose, two days of the month)
I have also heard that the japanese believe in astaxanthin... and they see 100 years easy. I would always say .... get a gooooooood source of astaxanthin.... like valasta or astareal. . Not those cheapy cheapy ones you find in walmart.
Talking about Astaxanthin... I have been wondering why all longevity experts talk about taking fish oil, but nobody mentions krill oil. When I compare the two, krill oil would seem superior to me as it has what fish oil has plus Astaxanthin. A Capsule has much less of it than one of the studies you presented mentions, so it should not hopefully cause the issues you worry about. Just curious what your take on krill oil is...
From what I've seen, the doses of Omega-3 in krill oil supplements are miniscule and the price is high. Although, Rhonda Patrick thinks it may be of use for Alzheimer's patients, as its chemical form is more bioavailable for people with a compromised blood-brain barrier.
I think is safe to use 4mg of astaxanthin every day, because many of sea foods have more in 100 grams like shrimps, who have 13mg. Tuna 6mg. Eathing shrimps or tuna every day is not safe, because they have too much powerful antioxidant astaxanthin? I don't think so.
Great point! Just read this, "Among the wild salmonids, the maximum astaxanthin content in wild Oncorhynchus species was reported in the range of 26 - 38 mg/kg flesh in sockeye salmon" So, using those figures, a 200 g serving of sockeye salmon may contain approximately 5.2 mg - 7.6 mg of astaxanthin
I think taking to many supplements that may increase lifespan is a risky strategy. Because you may find that instead of increasing lifespan you may do the opposite. Taking one or two that has proof of not interacting is a good is idea but taking a cocktail of supplents may not help
![Astaxanthin for Skin Anti-Aging: Does it work? [Study 285 Analysis]](http://i.ytimg.com/vi/gI5XyVY_-n8/mqdefault.jpg)
New lifespan study: link.springer.com/article/10.1007/s11357-023-01011-0
💊 MicroVitamin (multivitamin & mineral that I take): drstanfield.com/products/microvitamin
📜 Roadmap - how to look young & feel strong: drstanfield.com/pages/roadmap
You don't find it weird that you talk about a new finding every few days that somehow magically extends life by 10%? How can so many different things have such a big impact on longevity? There are mistakes being made somewhere. There is zero chance that any of these things are extending life that much. Imagine thinking you can stack a few products and magically extend your life by 50% lol.
Hey Brad, you are looking week by week older and older, weaker and weaker...what's going on? Should I send our nutrition and supplementation protocol? We never get ill (even not a little bit) since decades and looking decades younger. 😊
Can vitamin B9(folate/L-5-MTHF), B3, B12, ZINC, vit A, vit C, vit D, Quercetin Which of these supplements be taken in conditions like too much urination and UTI? @DrBradStanfield
@@TurKishsoulja It's all a matter of healthy living. Huge studies, the past few years, involving close to a million people, show multiple cups of coffee a day extend life. We're talking an extra 5 to 10 years. And this was first shown in the 18th century. Point is,.. coffee is loaded with antioxidants. If you eat right, get all your nutrients you'll live longer. Unfortunately, as we age, we need to get help with nutrients through supplementation.
What do you think about hydrogen water, and hydrogen water bottles that are sell.
So I had severe arthritis for ever, tried everything, then began with Astaxanthin, after 2 weeks of 24mg per day, the arthritis almost disappeared, that was 6 years ago. I recommend it to all my friends of age 50 plus.
Even my doctor wanted to know how I did it.
Life changing.
@espenforfen, good day. Can you be so kind to advise which astaxanthin product you used to achieve your results? It will be great to know nd I'd be very grateful.
would also like to know which product
I have not tried Astaxanthin yet, but I thank you for this testimony. Last but not least, very happy to read that it killed your severe arthritis in a bunch of weeks ☺
What other supplements are you combining with Astaxanthin?
I think you are ignoring the basic results....astaxanthin extends lifespan in yeast, worms and mice. NIH ITP study of mice lifespan shows 12% life extension in mice. As good as rapamycin alone for the same test protocol, which has only identified about 4 items with 10% plus life extension.. The vitamin E and most other antioxidants have not been shown to extend lifespan. IMO, this implies that astaxanthin has some other significant mechanism of action besides acting as an antioxidant to extend lifespan. Furthermore, it is very safe, so anyone wanting to extend lifespan with minimal risk would be foolish not to consider astaxanthin. If you want to wait for life extension protocols that are fully proven, you will be dead before that happens...life and success are all about caclulated risks.
quite possibly. My point is that before getting too carried away with the results, I'd prefer to have more trials in humans. Particularly since NO ANTIOXIDANT supplement has been shown to offer benefits for otherwise healthy people (as per that Cochrane review, and multiple reviews since then)
I worry about taking it as a former smoker because of the risks associated with beta-carotene and former smokers.
@DrBradStanfield NDGA is one of the 4 ITP identified molecules shdown to give 10% plus life extension in males, and us a powerful Antioxidant in it's own right.
Also, don't ignore the fact that astaxanthin is a powerful Antioxidant in BOTH aqueous and fat, AND, is one of only a few antioxidants which can operate inside the mitochondria...
I think these observations show the possibility that astaxanthin, even as an antioxidant, may have fundamental mechanisms beyond almost all others. Although desirable.
I don't think we need to know the exact mechanism for how something works to take advantage of it after a risk/benefit analysis. Not everyone is around 30 years old as you are...
I think risk benefit analysis would say anyone over 40 should almost certainly take astaxanthin.
@@hi_im_gush Does the risk extend to former smokers as well? I thought it only affects current smokers.
@@DrBradStanfieldwhat do you think about methylene blue
Thank you for reviewing the studies on Astaxanthin since there weren't many video reviewing it for the last decade.
I started taking 12mg daily 11 years ago (when I was 33) after getting some bad sunburns on glacier climbs. I was already taking turmeric and eating lots of frozen wild blueberries and wanted to try a supplement to reduce the risk of sunburns on long bike rides in California.
I haven't had a bad sunburn since I started taking Astaxanthin and my skin seems to have aged less than my half-brother who is 9 years younger.
Another side benefit of taking Astaxanthin for 11 years is that I appear to be somewhat tan year-round even in cloudy Seattle. If it's enough to turn farmed salmon from grey to pink, it is likely doing that to my muscles and fat as well but at least the whites of my eyes are still white.
that's good for you. thanks for letting me know
I was taking Astaxanthin for 16 years in itd best form. Skin wise it helped i think specially in the sun i never used sunscreen. Antioxidant wise it refreshed me after poor sleep
Astaxanthin has another effect on longevity that isn't commonly known. When studies were done on centenarians (people who live over 100 years of age), they found that many of them produced a very specific variant of FOX03. This specific variant seemed to have all kinds of health benefits from keeping immune systems strong, to cognition. It seemed like a good puzzle piece for why centenarians seem to not only live long, but with good health until their deaths. The trouble is that most people do not produce that specific variant of FOX03... it was found that astaxanthin can actually promote production of that longevity FOX03 variant, essentially mimicking the increased expression that centenarians have. That is why I started taking it (my DNA test unfortunately revealed that I don't have the longevity version of the gene). I think this may be another reason it shows 12% increase in lifespan, not just from a NRF2 standpoint.
In your opinion, what would be the ideal dose of astaxanthin to take per day? One natural health guru said 16mg per day seemed to be ideal for him.
About that at ScienceDaily:
"Astaxanthin compound found to switch on the FOX03 'Longevity Gene' in mice"
An Astaxanthin compound has been found to switch on the FOX03 'Longevity Gene' in a study using mice. Researchers measured a nearly 90% increase in the activation of the gene in the animals' heart tissue.
I couldn't see any disclosure from the authors. I suspect they have some non-diclosed company interests.
@@bigguy130 I think there is a balance where too much is not good. A lot of antioxidant effects and even NRF2 activation might make someone feel good and reduce inflammation, but it doesn't always fix underlying issues and might even increase susceptibility for infection by removing the immunity “weapons” from the IFN-gamma cascade. For example, NRF2 has been shown to reduce pro-inflammatory cytokines like IL‐1β, IL‐6, TNF‐α and IL‐18 (not always a good thing), which can reduce immunity, and also down regulates production of NLRP3 inflammasome which is important in fighting infections (study reference: "NLRP3 Inflammasome-A Key Player in Antiviral Responses"). Another study looked at the reduction in immunity to fungal infection due to NRF2. Likewise in cancer, NRF2 inhibition may be important (study reference: "Nrf2 in cancers: A double‐edged sword". You can check out a 2021 publication that has references to many other studies on the matter ("Smoking‐aggravated oral candidiasis: Nrf2 pathway dampens NLRP3 inflammasome").
Another thing I'm considering is that astaxanthin builds up in the system like other carotenoids, so I think a lower dose over time is more prudent. For example, I take 4 krill oil gel caps with astaxanthin in it every morning with eggs (Kirkland brand from Costco), and that that is about 750 mcg per cap (total of 3 mg a day), and I eat salmon once a week too. This is just my opinion, but it is more intuitive to me to get high amounts in the "high range" of what a diet might provide simply because of the negative issues with too much NRF2 and antioxidants. I think 16 mg from a dedicated supplement might be in dangerous territory over time (as it accumulates).
@@larsnystrom6698 The National Institute of Health (NIH) partly funded the study, and I tend to think government collaborated studies tend to have less agendas. Dr. Bradley Wilcox was the principle investigator from the NIH, and he is quite reputable from what I have read. Copied: "Dr. Bradley Willcox, MD, Professor and Director of Research at the Department of Geriatric Medicine, JABSOM, and Principal Investigator of the National Institutes of Health-funded Kuakini Hawaii Lifespan and Healthspan Studies."
"Centurians"? Is that even a word? Do you mean "centenarians"? Aye-ay-aye!
Yes…I started taking 4mg almost daily about 5 yrs ago since my eyesight was getting bad..to the point I had to have trifocals…after about a year I hardly need any glasses…I can read and see well..in fact not wearing any now and no issues writing this or watching the TV..I would also have an issue where twice a year or so I would end up with a sore knee or knees that is gone now also…and also noticed my skin looks healthy and I don’t burn easily in the sun anymore..anywoo that is my story.
Which brand? Cheers!
@@dom2484 I take Bio Astin from Hawaii..it’s not expensive and have had zero issues…while some will say to take 12 mg based on research ..I’ve found that just 4 a day after a meal is fine for my issues of eyesight and joint pain and skin…
I wonder how it compares to retinol in liver.
I've been taking it for about 9 years now. I still look the same. It probably has helped stop wrinkles and skin damage as well as many other benefits that aren't immediately apparent
how much do you take?
So are you saying it has helped after 9 years? You still look the same. That should be a plus right.
Good detail in your video . I saw that Japanese researchers have helped patienrs with heart and liver problems with 12 mg doses of astaxanthin . Their x-rays showed reversal of probably fibrosis , which is significant . Studies report that astaxanthin stops or slows TNF beta 1 , which is essential for fibrosis .
I agree more research is needed for astaxanthin as a supplement. I am taking Glycine and NAC which has made a huge difference to my asthma and lung function overall. As a licensed aesthetician we have known the antioxidant benefits of astaxanthin in skin care products for quite awhile and you will find it included in many well researched brands. Try to find it in liposomal form for increased penetration paired with other great antioxidants such as Ubiquinone, Glutathione and Ergothioneine.
Thanks for sharing your experience
Topical astaxanthin is an underexplored agent. As far as properties I like that it it can distribute in both hydrophobic and hydrophilic spaces as well as localize to the mitochondria. But the ITP is what really counts, theory can only take you so far. Now it's time to test in humans. That has already begun and there's a nontrivial amount of work done here before but typically lower doses for specific conditions (and based on animal studies examining certain eye conditions healthy brain aging / neuroprotection, cardiovascular, etc).
Taking glutathione as a supplement is risky as it can easily do more harm than good, resulting in a shorter lifespan.
Glutathione is the most potent antioxidant in the body. This potency means that too much in any cell type can do great harm.
Your cells regulate their own glutathione level as the amount required varies depending on tissue type, the amount of work the cell is doing, health status, etc. There is no single, good level for the whole body, at any time.
However, glutathione production does decrease with age and in an inflammatory environment, and higher levels are associated with a longer lifespan.
Taking into account all of the above, the safest way to boost glutathione is to supplement with components your cells can use to produce it.
Among the best of these are Glycine and NAC (particularly glycine).
Another is Selenium. Selenium supplementation alone has been shown to increase glutathione levels in tissues, but be careful with the dosage - 200 mcg per day and above has been shown to have negative health effects in some people. 50-100 mcg is probably better for most people.
Glycine you can take lots of, as in many grams per day. It is well tolerated in high doses and also has numerous other benefits that help with aging.
NAC has also shown good results but mainly when combined with glycine. It mainly helps by providing the sulfur that's required to produce glutathione. Some foods also contain a lot of sulfur, such as eggs, broccoli, cabbage, brussels sprouts (most smelly greens). Consuming any of these while supplementing with glycine should have a similar effect to taking NAC.
@@DrBradStanfieldHello sir. I have learnt chemical sunscreens are ineffective against photoaging caused by blue light emitted from mobile phones and monitors.
Only mineral sunscreens protects from blue light.
Shouldn't we be using mineral sunscreens provided that we are spending more time in front os screen rather than sun now a days.
@@antonystringfellow5152
Glycine is just an amino acid
What's not mentioned is Astaxanthin's ability to start a proliferation of stem cells and increase their potency in the body which I would assume would extend life.
I've been taking the last 2 years as part of an anti-cancer regimen. Love that it also extends life, especially as a cancer survivor.
In mice. Hopefully in people too. This is why we need to support this research. Hopefully will show benefits outside of certain cancer too.
If you think about it, any intervention that does not is either ineffective or trades one health issue for another.
love to know what is your anti-cancer regimen? Thanks
@@Aman-zi6us .
Every good wish for your continued progress and a long healthy life.
Apparently, moringa is just as good at activating Nrf2 as sulforaphane and is much easier to consume than broccoli sprouts. (Source: Jed Fahey in Rhonda Patrick's interview). Also, it is way cheaper than Astaxanthin, and, reportedly, helps with blood sugar.
This is irrelevant because Moringas iron content is not very bioavailable. Non heme iron.
Took Moringa for about a year..only downside I saw was it reduced testosterone .however, did help with enlarged prostate it seems.
@@DeathSentryCoH Is it just your personal observation or something that has been studied?
Yes, although we are lacking well powered, randomized controlled trials to make any definitive conclusions about benefits and risks. Personally, I don’t supplement with Moringa
Moringa powder can be purified but depends on the source. I am not endorsing any particular product (or substance for that matter) but generally speaking I personally (and others may find helpful) subscribe to ConsumerLabs. There is a membership fee, but they do third party testing of common consumables. I personally try to mitigate my exposure to heavy metals by sourcing my food carefully. Independent testing by unaffiliated auditors (certificate of purity) is something I value.
This molecule evolved for one purpose only- protection from solar radiation, that sounds like something that would benefit humans. I mainlu take it for eye and skin health. As an airline pilot I also am exposed to more solar radiation than most. I had a dermatologist tell me that she sees a lot of pilots.
someone says "protect the liver, feed the guts"...i add "protect the mithocondria too"
Take higher dose in the summer to prevent sunburns because I dont like sunscreens. It really does help. Take it for years and got perfect skin and no wrinkles.
Which brand? Cheers!
One of the scientist that worked on that mentioned this supplement was considered because it was an M tor inhibitor like rapamyacin. I think that is actually the cause of the lifespan extension, not the antioxidant part.
Do you remember the source?
it under the unpublished section of the interview. he also mentions bonine is a stronger mtor inhibitor than astaxanthin but I wouldn't take it because it lowers acetylcholine in the brain, it is an inhibitor, which would decrease brain health which would lead to quicker deterioration of the brain. @@viracocha2021
Would be interesting to combine it with HMB then
Yup. I take 10mg Astaxanthin at least 5 times a week.
I also divide a 10mg caplet among my 3 cats once a week. IMHO all diseases begin as inflammation. Suppress inflammation!
is it an oil soluble form or just dry powdered form?
Acute inflammation is good. Chronic inflammation is not good
@abc_cba It comes in various types, so to speak, but I've found that capsules with BROWN COLORED *POWDER* are the best. It's water soluble so I just pull a capsule apart & sprinkle it over their wet food, e.g. Friskies.
It's important to know that smoking cigarettes also activates Nrf2.
Thank you for this very well-rounded clinically oriented review Dr, I appreciate the brevity and comprehensiveness very much
Hello, Dr. Stanfield. This is easily my favorite supplement. I have been taking 12 mg daily for years. I will publish a video on astaxanthin in the next few days. I am almost done with the script. You made a huge mistake in your explanation that astaxanthin can harm the balance between oxidants and antioxidants. That's not true. I will provide absolute proof of this in my video. All the best to you!
*Bingo! Ditto!* Furthermore, Dr. J0seph M#rcol@ has been talking about Astaxanthin for YEARS, WELL before many of these folks were even born. ;0)
Thanks. Looking forward to your video.
I’m curious to hear your explanation as to why astaxanthin, via its NRF2 activation, can’t disrupt the balance between oxidants and antioxidants (particularly after exercise)?
Also interested in the human research you present. From the meta-analyses that I present in the video, from what I can see we lack robust data
I look forward to checking it out. I've posted my "quick and dirty" on the ITP through lense of aging biology research. I find interesting to see how different science communicators prioritize different aspects of the science. I could spend over an hour discussing the study but that's too much for the general listener. So I pick and choose, and we're all picking and choosing differently.
@@DrBradStanfield Dr. Stanfield, I made the video. Actually, I made two different videos on it.
I am sorry, but I just saw this comment. You will see that astaxanthin is in an entirely different category of antioxidants. It does not disturb the balance between oxidants and antioxidants at all.
I’ve been taking xanthins (astra and zeo) for a while for eye health … guess I’ll continue to do so.
When’s the Taurine video dropping? I’ve used 3grams for past 6 months and like it.
Thanks for being so succinct.
It's an art.
They used a really high dosage of Astaxanthin for the mice, 1840 ppm in their food, for the life extension study. Using the rule of three several times or just the rule of thumb, 1ppm ≙ 1/7 mg/kg mouse body weight, that's 263 mg/kg mouse body weight. Or around 21mg/kg human body weight. Or about 1.2 g for a 60 kg human. That's unfeasible for anyone's wallet.
It is expensive and less tested at those kind of doses. The ITP has not tested at lesser doses so it will be interesting to see the dose response curve on efficacy in mice. Not the same as human data but may be some indication whether the small doses in conventional OTC are worth the premium. Of course, I coach in longevity medicine so you must imagine I'm willing to spend a great deal (by %) on products I believe are valuable.
@@JohnnyMagorish 😂😂😂😂😂
@@JohnnyMagorish maybe a "Minion" or for those of us who remember (dating myself) perhaps a muppet! In all seriousness I think Brad takes on a challenging role which is offering people suggestions when data is early / preliminary. Different folks will make different choices (whether, and how much, each with their own risk/benefit profile but an elusive one since so little data available particularly on the efficacy side).
Just need to take it Long time untill it becomes saturated in the body
Usually the dosage is reduced by 10 fold for humans from mice for equivalence
I was having intense back and leg pain. I took 15 squirts of Valasta and in 10 days the pain was gone. You can never tell me it does not work.
if you take the precursor of sulforaphane, glucorophanin and take a myrosinase enzyme with that such as adding a seasoning of ground brown mustard seed to your broccoli or taking it in a cap, surely this gets around the instability issue of sulforaphane. Many sulforaphane supplements come as that combination rather than in the form of sulforaphane.
GlyNAC: You might not live longer, but with all the depression and listlessness it will feel that way for sure.
Your chanel is a great discovery 😍I regret I did not know it before 😣Thank you so much for the great information you are sharing
Top quality content! Thank you!!!🧡
Thanks, at 67, been taking astaxanthin between 6mg to 12mg/day for last 8 years. Insights on exercise impact helpful.
Any effect on skin aging like elasticity, and wrinkles?
Everyone is gatekeeping this stuff lol
I take Astaxanthin for some time now to recover from multiple tendon issues and it works great for me. However as soon as the tendon issues have fully healed I want to phase it out.
Thank you for this interesting video and your thorough research, as always! 😊
I'm under 60, but I would like to know if makes sense to take oral astaxantin for UV protection.
I use sunscreen every day, even in winter (central Europe). However, I thought since UV radiation in my region is not so strong in winter, I thought it might be better for the skin to avoid too much creaming, let it regulate its moisture itself and take oral sun protection instead. (In summer, I always use sunscreen.)
What's your opinion on this?
Thanks in advance!
I'm over 60 and have decided to take astaxanthin intermittently, like one month on, and one month off, or perhaps two or three months off. The idea being to get some repair work done without being constantly soaked in antioxidants, for the reasons Dr. Stanfield explains.
This is about protein, Mische PHD (youtuber) went over a recent meta-analysis of protein use in older people that found no statistically significant difference between people who got low to RDA recommended protein and elderly people who got significantly more protein. It seems that in real world testing, protein may not be very helpful for the elderly. Exercise is far more important. Trying to cram in so much protein can also lower important hormones like testosterone. With that in mind, I'll be sticking to around RDA levels of protein. Thanks for all your work, I have learned a lot from your videos!
Yeah, more than ~50g of protein a day for people 65 and older shows a high risk for developing cancer or diabetes.
protein is good to develop muscle more quickly. Exercise is both necessary to develop that muscle and good for health. You can skip the first one if you aren't in a hurry
your skin looks nicer today!
Dude awesome video! Your title definitely got my attention big time.
Geat video. Do glynac activate NRF2, or just increase the glutathione level?
It’s really good in krill oil.
Uric acid medicine has been taken by the world's oldest living man and his diet is customized to reduce uric acid in his body. Allopurinol is a popular medicine to reduce uric acid and has been shown to extend life. What do you think about allopurinol and medicine to reduce uric acid?
i take 8mg daily. it helps eyes and skin and heart and everything. why i should not take...
Hello Brad ,
Do you know the dose used in the studies ?
When talking about anti-oxidants, a key point is whether they actually reach the mitochondria where a lot of the oxidative stress starts. There might be more, but I am only aware of two - Glutathione, and Ergothioneine. I hadn't heard of Astaxanthin reaching these locations (and I am 99% sure Beta-carotin and vitamin E don't), but I was under the impression that it crosses the blood-brain barrier.
I personally think that everybody should add supplements for ergothioneine twice a month. But don't buy a pill - get a carton of mushrooms.
Astaxanthin is a xanthophyll carotenoid that has been shown to have antioxidant properties and may prevent mitochondrial dysfunction by permeating the cell membrane and co-localizing within mitochondria. It has been suggested that astaxanthin can neutralize free radicals in mitochondrial membranes, resulting in an increase in cellular energy production. Astaxanthin has also been shown to maintain mitochondrial integrity and prevent oxidative stress. Therefore, it is possible that astaxanthin reaches the mitochondria and has a positive effect on mitochondrial function.
(check Bing AI to see the full excerpt with links)
Hydrogen Rich Water is shown to reach mitochondria and specifically target the toxic oxidative stress but not the oxidative stress required for basic functions.
Sugar reaches mitochondria easily
what kind of mushrooms?
@@scottishfoldmocha5875Oyster mushrooms are probably the best source commonly available.
Do we have any biomarker that we can order with our blood panel to check this oxidant/anti balance? I heard the GSH/GSSG. Any thoughts?
Another step closer to mice inmortality 🐀
Isn't glycine the gluthatione rate limiting factor? Would adding NAC be a good idea for someone relatively young, say, in the 30's ?
I have a feeling that our western style of isolating factors are limiting the effectiveness of these molecules due to their synthetic applications.
If you don’t isolate then how will you know which item caused the effect?
Thank you for you recommend . I love Astaxanthin.
I eat blueberries daily for the last 5 years with polish kefir and walnuts / almonds and olive oil
Exercise daily
Eat collagen peptides daily for the last 4 years
and Haluronic Acid
as funny as this might sound but I barely have any wrinkles (I'm 41)
Jaki Polski jogurt? Gdzie mieszkasz?
I'm 40, smoked from 13 years of age to 39, been drinking lots of alcohol, eating poor food, bad sleep, no exercising, and I spend a lot of time in the sun during summer.. and, I have no wrinkles.
40 year olds don't have wrinkles, wait till you're 60, that's when it starts.
Which brand of hyaluronic acid capsules do you take, please? Cheers ^_^
Great video thanks. I have a question. I learned from you seems that I shall not take antioxidant supplements before or during weightlifting training. But how about right after training? Can I or how long I have to wait before taking antioxidant supplements? Thanks
Do you have any theory why betacarotene in blood is one of the biggest predictors of longevity (even in a dose dependant correlation 10.1093/ajcn/nqy097) but betacarotene supplementation is not?
Is it possible that eating the plant instead of the supplement is helping us somehow?
💎Astaxanthin is a potent 5-Alpha-Reductase Inhibitor (Like Finesteride), and as such, can cause symptoms similar to the side effects seen with Finesteride: This condition, termed post-finasteride syndrome (PFS) is characterized by sexual side effects (i.e., low libido, erectile dysfunction, decreased arousal and difficulty in achieving orgasm), depression, anxiety and cognitive complaints that are still present despite drug withdrawal 🔴🔴🔴 (Diviccaro et al., 2020).
The dose makes the poison. I am aware of no quality data in humans at the doses in OTC meds. Having said that, to your point, no quality evidence (or any for that matter) on lifespan in humans though some small condition-specific trials.
So you don't recommend it?
I'm currently on Finasteride and I would appreciate your response here.
Can I take Astaxanthin as well?
I'm highly interested because of the research I have done so far sounds very attractive.
However I am a little confused
Some research talk about increase in sperm and testosterone levels.
Whilst some others talk about erectile dysfunction and lower libido and breast growth in men.
Thanks for taking the time to get back if possible.😊
Dang. I took it and got nothing. Still was debating 😢
NAC has a mood flattening effect I was feeling depressed stopped taking it and the depression went away.
Take it at night
My head is spinning.
Is the 12% figure for the whole population or for the male mice only? Because if it's for the whole population and female mice weren't affected, then it's like a 24% increase in lifespan in male mice and this is huge. Those of us who are male mice would like to know!
12% for male mice :-)
Dr Brad I really like your videos. But i want to point out that I remember there was a study saying that taking beta carotene in supplement form as opposed to getting in food was harmful, not when you get it in foods that have other natural vitamins and things along with beta carotene that work together in a beneficial way. I also remember a study correlating high carotenoid levels with health and longevity. I have been taking 8 to 12 mg of astaxanthin for 90% of the time since 2009 and I am 60 now and I believe it has slowed down the aging process. How do you know for sure the 2 supplements you recomended are safer when there are so many possible effects on other things in the body. Since astaxanthin is found in nature would it not be less likely to have some bad unknown side effects.
I took this and after 2 weeks I was totally impotent. Returned to normal after stopping after few days.
What brand?
I use 16mg a day for a more natural skin-tone (anything but white). Pleasantly surprised by its health benefits.
Yooo it's been a while, back to mitochondria
This is good. I ate loads of sockeye salmon today.
Your title is EXTREMELY misleading
It's a bit strange that you reject Astaxanthin because it's an anti-oxidant like Beta-Carotene and Vitamin E, but at the same time endorse NAC, which also is an anti-oxidant and comes with many quite risky side-effects, including cancer. NAC hasn't been shown to increase lifespan, GlyNac only in inbred "black 6" mice with short-lived controls, whereas Astaxanthin did extend life by 12% in three separate cohorts of genetically diverse mice.
I tried NAC and i felt like i was dying lol i couldnt even work properly had to go home and recover
Because they dont want you better ,they want you sick ,NAC is horrible
He has a thing against antioxidants because oxidants are released during exercise, so he believes they are not that bad. As astaxanthin is one of the most powerful antioxidants in nature, supporting it would mean he is fundamentally wrong. If he is capable of changing his mind he will, but nevertheless he didn't reject it, he only wants more reassurance. You are absolutely right about this being better, and it's present in foods already
great video, thank you. can you please make a video on olive oil. the olive oil is the most debated issue of our days. many experts now are saying no olive oil. only a few Dr. are saying yes to olive oil.. Dr. Greger is against olive oil. a video on PS phosphatylserine willbe great too. i am a 47 year old . i have been a pharmacist for 16 years. PS is the only supplement that has made a difference when it comes to memory and retention of information. i have tried every single. product for 16 years, including the best fish oil ( perque ) nothing come closed to PS for memory. Rhodiola was great, but i got pain in my kidneys. you are taking crestor 5 mg. i was thinking to add it to my regime, but i am afraid of side effect, Diabetes and joint pain. I have eating your perfect meal for over 10 years and my LDL is at 120. it does not want to come down.
Krill oil has astaxanthin, sufficient enough i hope. I try to alternate or mix it with cod liver oil.
Combine astaxanthin with tocotrienole and Omega 3 (yet not from fish oil but rather Krill oil or Algae oil) that’s a great triple
Can vitamin B9(folate/L-5-MTHF), B3, B12, ZINC, vit A, vit C, vit D, Quercetin Which of these supplements be taken in conditions like too much urination and UTI? @DrbradStanfield
Take Cordyceps.
Hello, Dr. Stanfield. Is there anything helpful to blunt the purported anhedonic effects from NAC? Also, thank you for your perspective and insight into astaxanthin.
I assure you that your question will NOT be answered.
Dr. B. Now I came across a different form of NAC. What is your opinion about Augmented NAC. Its expensive $$$. The makers & their studies praise that it neutralizes COVID spike. I may try it for Fibro/Chronic Fatigue Syndrome of 20+ yrs & worsening that may have been induced by EBV? A.K.A. "The Original Long Covid"!
Why do we listen to this man any longer? The videos are titled to lure viewers in but his recommendation are always "we need more studies." If there isn't a Chochrane review that Dr. Standfield can hide behind he'll never have the courage to recommend any supplement in fear of professional consequences at home. There are far better non-doctored experts on nutrition and supplements to be found on UA-cam worthy of ones time who delve far deeper in to the details of medical literature than simply summarizing meta-analyses.
Well said! Additionally, I strongly suspect he is working for Big Pharma to discourage people from taking supplements, so they remain dependent on prescription drugs.
When will we get readouts from the Mayo clinic coordinated fisetin trials?
Thank you🤩👁️💊💯💙
antioxidants only mop up a small amount of the many oxidants in our body, so there is no fear that it will neutralise all of them
You are outstanding.
At first it sounded like astaxanthin did not have the potential drawbacks of other antioxidants, but then...
Are you aware that antioxidants in food have positive outcomes in studies as opposed to the typical supplemented ones? I think there's gotta be a way to maximize that benefit from supplementation with the right stuff. I don't want to start delaying aging only at 60.
Does astaxanthin only provide the body with additional antioxidant capacity exactly where needed or can it also help to eliminate/reduce the effects of eccess antioxidants, which might arise from conumnption of vitamin A, vitamine E or curcumin?
well i have some astaxanthin in the cupboard somewhere so i will give it a go
Does an excess of antioxidants cause a decrease in the immune system, so a greater risk of cancer and infections?
Nice to see a doctor making a video to not recommend a supplement and provide education on it
Sound like you got this from Pete Attia's Drive podcast. Rather exciting if it works for humans.
AFAIK I was the first to post the actual published manuscript on Twitter (When Rich Miller was on Peter Attia's podcast it was just a preprint twinkle in Rich Miller's eye!).
Appreciate Brad making the info more widely available, moreover science communication to general audiences.
TY Brad.
Thank you for another great presentation. I'm 61 in three months. I do experience inflammation bouts (I eat heathy, primarily carnivore after years of eating healthy foods which contained too many carbs!). Life catches up to the body, after many years in the military and that lifestyle. What would you think (just opinion as I know you are young still and not in my body) would be a good strategy to use an antioxidant, after exercising? Wait several hours for the positive effects of inflammation first, and perhaps then the antioxidant before bed perhaps to gain some adequate rest and get cortisol down?
Also, have you done a video on Ean natto Tocotrienols-Vitamin E? I have heard it surpasses the standard, and isn't a risk for cancer etc.
Thank again Dr. Brad-you rock!
thank you Brad.
Have you ever played WoW and it seemed you're just chasing the 'flavor of the month' class? Almost as if Blizzard themselves are making specific classes over-powered on purpose in cycles so folks will re-roll other classes and keep them subscribed. I feel like the supplement industry is doing this with these 'lifespan increasing' 'super-duper awesome' supplements.
Both are money making machines for sure…
Thats why you will always be a dog chasing its tail unless you develop the ability to find and authenticate clinical trials yourself
Eh IDK about this review. You stated "there are substantial risks" but didn't state those risks in any documentation, you also skipped over the Oxidative stress study which specifically points to significant reductions in MDA etc. Likewise I feel like you focused too much on the "antioxidant" label here rather than the other interesting things Astaxanthin does, specifically around p38 inhibition, MAPK signaling/protein regulation etc. etc. etc.
I’ve heard a concerning side effect in men that Astaxanthin can cause hormonal changes in men who develop Gynecomastia. Could you please comment on this as I am currently taking Astaxanthin but definitely do not want moobs! Thanks!
I wonder if astaxanthin being taken from algae has a noticeable side effect on people sensitive to seafood or algae itself.
And the stack list gets longer 😏
Does glycine n NAC come in one supplement? And what dosage should I take? I’m healthy and active.
I take 2000 mg nac
6000 mg glycine
Per day
you look great
Astaxanthin?
You could easily do better just by increasing your VO2 max, and all that costs is your time.
So many of the longevity supplements that get so much attention seem to fall into the category of anti oxidants. By taking multiple anti oxidants are we being redundant? For example, could we just take Gly-Nac to allow the body to increase glutathione and let that do all of the anti oxidizing? Or, do different anti oxidants neutralize different kinds of oxidants? Also could astaxanthin be a good "hit and run" treatment? (Say high dose, two days of the month)
You missed the most important point: astaxanthin helps eye health.
There is more better data for other carotenoids but it is being studied.( eg lutein and zeaxanthin for macular degeneration)
Do young people need antioxidants then or do they produce enough themselves?
I have also heard that the japanese believe in astaxanthin... and they see 100 years easy. I would always say .... get a gooooooood source of astaxanthin.... like valasta or astareal. . Not those cheapy cheapy ones you find in walmart.
Great video! I've been taking Taurine recently, but I just wonder if its really destroying positive effects of exercise.
I haven't heard anything about that.
What do you mean? Care to explicate?
Talking about Astaxanthin... I have been wondering why all longevity experts talk about taking fish oil, but nobody mentions krill oil. When I compare the two, krill oil would seem superior to me as it has what fish oil has plus Astaxanthin. A Capsule has much less of it than one of the studies you presented mentions, so it should not hopefully cause the issues you worry about. Just curious what your take on krill oil is...
From what I've seen, the doses of Omega-3 in krill oil supplements are miniscule and the price is high. Although, Rhonda Patrick thinks it may be of use for Alzheimer's patients, as its chemical form is more bioavailable for people with a compromised blood-brain barrier.
I think is safe to use 4mg of astaxanthin every day, because many of sea foods have more in 100 grams like shrimps, who have 13mg. Tuna 6mg. Eathing shrimps or tuna every day is not safe, because they have too much powerful antioxidant astaxanthin? I don't think so.
Eating tuna everyday might result in unhealthy mercury levels in the body. I eat it at most once per week.
@@adamscottv My comment not about tuna
Great point! Just read this,
"Among the wild salmonids, the maximum astaxanthin content in wild Oncorhynchus species was reported in the range of 26 - 38 mg/kg flesh in sockeye salmon"
So, using those figures, a 200 g serving of sockeye salmon may contain approximately 5.2 mg - 7.6 mg of astaxanthin
Astaxanthin activates FOXO3.
I think taking to many supplements that may increase lifespan is a risky strategy. Because you may find that instead of increasing lifespan you may do the opposite. Taking one or two that has proof of not interacting is a good is idea but taking a cocktail of supplents may not help