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The itp study used young mice. Young animals carry low senolytic loads and are unlikely to see effects from antisenolytics. Why not use older mice? Useless study, raises suspicions
Apples are the fruit that is the most associated with lower all cause mortality. People who eat a lot of apples have been shown to have 25% less all cause mortality, which apparently is much better than fruits in general, which lower mortality by than 10%.
Hi thanks for the question. I know that the opinions given in the three segments differ. I think that is just where the study is at the moment. Dr Green is a practicing doctor and said what he used. 100 mg of dasatinib, 1g quercetin 2 days in a row every two weeks or 1.2g fisetin 5 days in a row once a month. (though please listen to his section). In the clinical trials I think the dose was 20mg/kg for fisetin for 2 days in a row (NCT ID: NCT03675724)
Metformin lowers glucose, insulin and inflammation. This alone is life extending. Also, those were all mice studies. Metformin benefits increase after years of taking it.
Hi Bailey, thanks for your comment. It would be great to have some way of measuring the systemic senescent cell burden so that you could titrate the dose to the correct level.
Quercetin has been known to cause kidney damage in doses of 1000mg. Makes me wonder if it is safe to take at any dose. I am taking up to 250mg, but it does make me worry..
Hi thanks for your comment. At lower doses quercetin appears to be protecting the kidneys ("Protective effect of quercetin on kidney diseases: From chemistry to herbal medicines"). But I do see Mount Sinai web site says that there may be issues with 1g/day. One of the key points that all three interviewees made was that the dosing as a senolytic was intermittent. So taking quercetin at 1g perhaps 2 days a month (depending on the exact protocol)
Fisetin was never shown to have life extending benefits. In fact, the Intervention Testing Program showed it had no effect. Same goes for resveratrol and metformin,
@ModernHealthspan I saw that negative result for Fisetin by the Intervention Testing Program. It does not extend lifespan and does not affect senescent cells!
James Kirkland is not keen on selling anything. He's running a dozen trials in a network centered at the Mayo Clinic in humans. I'm waiting on these HUMAN TRIALS results before I pass judgement.
Hi thanks for your comment. But not sure of the meaning. In what way are senolytics not valid? We don't have excess senescent cells? Removing senescent cells doesn't help? senolytics don't remove them? The preclinical data is robust that removing senescent cells is beneficial in cases of diseases of aging.
@@ModernHealthspan Please speak with a cell biologist who studies the MANY TYPES of senescent cells and their beneficial or deleterious function, or Dr. Richard Miller who lives and breathes in vivo and doesn't have much patience for the highly questionable vitro sleight of hand researchers you are often platforming here as an adjunct to their research raise and product sale efforts. If its not repeated and its not vivo, its not real. And if it can’t be adequately targeted, an apoptotic substance is just a tissue poison with unknowable side effects.
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☕If you would like to support our channel, we’d love a coffee…thank you! www.buymeacoffee.com/mhealthspan
I don't know why they keep using the term "drug" for these supplements
I'm confused what's the dosage?
I could not understand the names of the drugs used and the transcript spelled them incorrectly, came away with more questions than answers.
When was this recorded? I heard that Judith Campisi has just passed away. :( Anyone got any news on what happened?
She passed away on 19 January from breast cancer.
It would be nice to know that approximate date of recording.
It says it unless you are that bad at reading @@Krunch2020
The itp study used young mice. Young animals carry low senolytic loads and are unlikely to see effects from antisenolytics. Why not use older mice? Useless study, raises suspicions
20 months old. Middle age.
Very interesting. Need to upgrade my consumption of apple skins.
Hi Elliott, thanks. Or strawberries (for fisetin) are good too.
Apples are the fruit that is the most associated with lower all cause mortality. People who eat a lot of apples have been shown to have 25% less all cause mortality, which apparently is much better than fruits in general, which lower mortality by than 10%.
So what is the time interval and dosage for human?
Hi thanks for the question. I know that the opinions given in the three segments differ. I think that is just where the study is at the moment. Dr Green is a practicing doctor and said what he used. 100 mg of dasatinib, 1g quercetin 2 days in a row every two weeks or 1.2g fisetin 5 days in a row once a month. (though please listen to his section). In the clinical trials I think the dose was 20mg/kg for fisetin for 2 days in a row (NCT ID: NCT03675724)
Metformin lowers glucose, insulin and inflammation. This alone is life extending. Also, those were all mice studies. Metformin benefits increase after years of taking it.
So does berberine and it's not a drug.
If use that seldomnly I would think the doses would need to be extremely high for such a few days.
Hi Bailey, thanks for your comment. It would be great to have some way of measuring the systemic senescent cell burden so that you could titrate the dose to the correct level.
Serious volume variation
Prof Kirkland and Prof Campisi are geniuses
Hi thanks!
Thanks Richard.
Hi Ron, thanks!
Quercetin has been known to cause kidney damage in doses of 1000mg. Makes me wonder if it is safe to take at any dose. I am taking up to 250mg, but it does make me worry..
Hi thanks for your comment. At lower doses quercetin appears to be protecting the kidneys ("Protective effect of quercetin on kidney diseases: From chemistry to herbal medicines"). But I do see Mount Sinai web site says that there may be issues with 1g/day. One of the key points that all three interviewees made was that the dosing as a senolytic was intermittent. So taking quercetin at 1g perhaps 2 days a month (depending on the exact protocol)
How about natural sources instead of supplements
My Dr has me on 500mg 3x per day of quercetin, I have had no adverse reaction
in this study quercetin was administered up to 5g a day without sideffects: pubmed.ncbi.nlm.nih.gov/26621580/@@ModernHealthspan
Hi, yes fyi i have been taking 1g and it has made one of my kidneys hurt.
Fisetin was never shown to have life extending benefits. In fact, the Intervention Testing Program showed it had no effect. Same goes for resveratrol and metformin,
@ModernHealthspan I saw that negative result for Fisetin by the Intervention Testing Program. It does not extend lifespan and does not affect senescent cells!
I've come to realize he's keener on selling supplements than presenting an accurate and balanced scientific view of the latest research.
James Kirkland is not keen on selling anything. He's running a dozen trials in a network centered at the Mayo Clinic in humans.
I'm waiting on these HUMAN TRIALS results before I pass judgement.
Nothing extends life other than fasting...a reduction of calories and perhaps exercise. The rest is disinformation
@@contro-ventohe’s not selling anything, it’s this site that has links.
Senolytics are a boondoggle.
Hi thanks for your comment. But not sure of the meaning. In what way are senolytics not valid? We don't have excess senescent cells? Removing senescent cells doesn't help? senolytics don't remove them? The preclinical data is robust that removing senescent cells is beneficial in cases of diseases of aging.
@@ModernHealthspan Please speak with a cell biologist who studies the MANY TYPES of senescent cells and their beneficial or deleterious function, or Dr. Richard Miller who lives and breathes in vivo and doesn't have much patience for the highly questionable vitro sleight of hand researchers you are often platforming here as an adjunct to their research raise and product sale efforts. If its not repeated and its not vivo, its not real. And if it can’t be adequately targeted, an apoptotic substance is just a tissue poison with unknowable side effects.
The real "boondoggle" is not doing any actual investigation into senolytics and then acting like you know something about it lol
@@ModernHealthspan We know in mice.
@@Corteum ua-cam.com/video/sZ-krUa6VH0/v-deo.htmlsi=SopQYz-YdzN9UJch&t=8321