Targeting Senescent Cells? Dose and Timing Matters - with Dr. Greg Kelly

Get ready for a deep dive into the world of cellular senescence and its implications for aging. Dr. Greg Kelly joins me on New Frontiers to explain the science behind targeting this Hallmark of Aging and share natural compounds and activities that target cellular senescence. I am particularly excited for you to hear his thoughts around dosing and cyclical timing of exposure to senolytic compounds, such as fisetin, luteolin, quercetin, and piperlongumine, and why that may make the difference between having the effect you want... or not. Don't miss his advice on smart exercise tweaks for aging and the caution that overdoing it with exercise in our later years is much more harmful than it was in our twenties. Lots to unpack here. Enjoy! - DrKF
Head over to www.drkarafitz... for all the full transcription and all relevant links and resources.
Guest information
Dr. Greg Kelly is Senior Director of Product Development at Neurohacker Collective, naturopathic physician (N.D.), and author of the book Shape Shift. Dr. Kelly was the editor of the journal Alternative Medicine Review and has published hundreds of articles on natural medicine and nutrition, contributed three chapters to the Textbook of Natural Medicine, and has more than 30 journal articles indexed on Pubmed.
[e-mail]
/ neurohackercollective
/ neurohacker
/ gregory-kelly-98b96b138
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If you’re in your late 20’s or older, adding Qualia Senolytic to your diet can play a CRUCIAL role in combating negative aging symptoms. Go to tinyurl.com/4m... for up to 50% off Qualia Senolytic and as a listener of New Frontiers podcast use code KARA at checkout for an extra 15% off your first purchase.
Show Notes
Dr. Gregory Kelly: neurohacker.co...
Neurohacker Collective: tinyurl.com/3z...
Shape Shift: tinyurl.com/3z...
Alternative Medicine Review: tinyurl.com/56...
Textbook of Natural Medicine: tinyurl.com/56...
Qualia Studies: neurohacker.co...
Inulin-Type Probiotics - A Review (Part 1 and 2): altmedrev.com/...
James Schmachtenberger: tinyurl.com/yj...
Daniel Schmachtenberger: tinyurl.com/yz...
Quercefit: tinyurl.com/46...
Study: The Hallmarks of Aging: tinyurl.com/5c...
Study: Hallmarks of aging: An expanding universe: tinyurl.com/2y...
The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs: tinyurl.com/3k...
The Clinical Potential of Senolytic Drugs: tinyurl.com/5x...
Epigenetic clock analyses of cellular senescence and ageing: tinyurl.com/4v...
The relationship between epigenetic age and the hallmarks of aging in human cells: tinyurl.com/34...
Qualia Mind: tinyurl.com/23...
Vittorio Sebastiano: tinyurl.com/4m...
DrKF Resources
FxMed Blog: The 12 biological hallmarks of aging viewed through a functional medicine and functional longevity lens: tinyurl.com/5n...
Decoding Aging: The Science Of Cellular Rejuvenation With Dr. Vittorio Sebastiano: tinyurl.com/2z...
DrKF Clinic: Patient consults with DrKF physicians including Younger You Concierge: www.drkarafitz...
Bio Age Lab Test: youngeryouprog...
Bio Age Self Assessment Quiz: youngeryouprog...
Younger You Group Program: www.drkarafitz...
Younger You book: youngeryouprog...
Better Broths and Healing Tonics book: youngeryouprog...
Dr. Fitzgerald is actively engaged in award-winning clinical research on epigenetics and longevity using a diet and lifestyle intervention developed in her research and practice. She has published two clinical studies on the potential bioage-reversing effects of an 8-week DNA methylation-supportive diet and lifestyle in middle-aged men and women and is the author of the bestselling book Younger You: How to Reduce Your Bio Age and Live Longer, Better.
Dr. Fitzgerald is on faculty at the Institute for Functional Medicine and lectures globally on functional medicine, longevity, and epigenetics to practitioners and consumers. She maintains an award-nominated podcast series, New Frontiers in Functional Medicine, that has amassed 2 million listens, and an active stream of forward-thinking content on her website, www.drkarafitzgerald.com. Her clinical practice, the New Frontiers Functional Medicine & Nutrition Clinic, is located in Newtown, Connecticut.
Senolytic, Qualia, Senescent Cells, Qualia Senolytic

[@sam19698487]

I fell for this one (Qualia Senolytic) and subscribed after I watched this video, but then cancelled subscription after I read their "Double-blind, placebo-controlled clinical trial of Qualia Senolytic". The study is actually based on a questionnaire of people who took the supplement and said they felt better. Very subjective, no measured data, no scientific method that can be re-produced by others. Also, the ingredients are typical anti-aging that can be found in other products, although you may need to combine 2 or 3 different brands. Qualia's cost $69/month for two days supply in concentrated form (12 tablets, 6/day per two days). Overall, my personal opinion is that the product is a bit gimmicky, greedy, and they lost my confidence with their claim of "Double-blind, placebo-controlled clinical trial". I prefer to see a real scientific, re-producible study backed by third-party researchers. It is a typical product from a company founded by business people, "entrepreneur", as opposed to scientists (... yes, yes, they all later on board Doctors to give their companies legitimacy... a proven formula). Also, heavily promoted by celebrity influencers like Dave Asprey (ughhh:( I like Dr. Kara's channel and her method of interviewing scientists, and will continue to follow her work. Just not happy with this particular video because it legitimized a product with no proven record (like so many other supplements out there).