Jonas thank you for your clear and thorough explanations. I understand that some folks consider that your presentations are too long but I very much appreciate the thorough descriptions of biochemical mechanism involved and scientific publication references.
@@JonasKuehneMD It does help in my understanding that I have a medical science background with particular interest in biochemistry and microbiology. My main interest is to help my partner who is in remission from breast cancer and my friend and former colleague who is stage 4 breast cancer in the lungs and about to restart treatment. I came across Dr Seyfried in my research but even though I understood what he was saying, it wasn’t convincing enough to share with folks without much basic background knowledge. By contrast your presentations are distilled and much easier to follow. Thank you!
@@lucdelhaize4029 Consider looking into diindolylmethane, curcumin phytosomes, Artemisinin, some BC patients are taking 2 to 3 thousand mg melatonin/day, investigate Brio Medical for their protocols.
Thank you for your kind words. It is still worrisome to me that many oncologists refuse to explore the abundant research on this topic. My explanation is that they are trained well by the medical establishment and pharmaceutical industry not to venture off into areas that are less lucrative.
@@JonasKuehneMD it seems that most oncologists are resigned to the idea that most of their patients will be dead within a few years and their job is to keep them busy with ineffective cancer treatments until they pass away, to keep their minds off their impending doom until they are very near death.
@@JonasKuehneMD Exactly ! Keep in consideration that , in Europe, doctors MUST follow Protocols officially approved . And, actually , those Protocols do not target Metabolism dysfunctions (Mitocondria). Very sad...
Thank you for your information. I couldn’t agree more as my husband is “dealing with” prostate cancer and following the metabolic protocol. The only thought I’d add is, “Good luck finding an oncologist who believes in any of this mumbo jumbo!” I just walked out of our oncologist’s office a couple of weeks ago because of his mocking, knowing it all attitude. I will never return. Dr Seyfried is a hero and I pray that the medical world will wake up one day…but I doubt it.
I’m very sorry to hear that. This reaction of your physician is the reflection of the pharma industry. Oncologist should know that cutting out sugars and decreasing glutamine can be immensely helpful. I have a had patient that had done metabolic therapy in combination with high dose intravenous vitamin C weekly. He only required very low doses of chemo and for a short time only.
Prostate cancer is very pernicious, the urologists are butchers, they use a meat cleaver when they should be using a scalpel. Prevention is key gotta drive insulin to baseline by going 0 carb, the continual insulin spikes over a long period of time are extremely dangerous and our urologists need to stress this but the will not because they benefit from our misery.
@@JonasKuehneMD btw I just noticed you are from Los Angeles. I have a friend who has recently been diagnosed with leukemia last month and is now currently doing chemo and it's pretty brutal. Are there an doctors in Los Angeles area that you know of that specialize in treatment that doesn't involve chemo and instead targets diet and less harsh medications? She's only 43, but I feel like there are better options than doing just chemo. Thanks in advance
And Mebendazole supposedly easier to cross the brain barrier for those with brain tumours, and how to protect our livers when taking these supplements.
Dr. Thank you so much. VERY good comprehensive video on EGCG. To be clear, does EGCG prevent glutamine uptake into ONLY cancer cells? Or both normal & cancer cells? How would this effect recovery from exercise? TYIA
Suzanne Somers wrote books on Cancer. She had breast cancer. But cancer finally did kill her. So many studies are done and what works for some doesn't always work for others
That is very true. I think it’s important to attack the disease from different angles. Therefore, metabolic therapy, mixed with supplements like green tea or berberine is a good start.
I believe Suzanne summers lived 20 years with breast cancer. It's possible she would have died much sooner without her nutrition and natural remedies. I know several people who did not do chemo and other mainstream treatments and did alternate treatments. All have died but lived MUCH longer than the doctors said they would with regular treatments. My wife's grandmother was given maybe a year if she did surgery and chemo. She did natural stuff and nutrition and lived 7 years
@@kennygee2715 Suzanne sommers had done chemotherapy. There is no one shoe fits all. I know many people who done chemo and are living today a normal life, and others I know that died. Don't look one way when you cross the street you will certainly get hit by a car. All bodies need the right foods, exercise on a daily basis. Fruits vegetables, nuts and some fish and some meat limited. Science plays a very large role in our lives and so does nutrition. If it were not for the advancement of medicine we would not be living as long. I only look at facts not fiction
@JonasKuehneMD hey what all comes under metabolic therapy. My mother is phyllodes breast tumor.. I'm giving her mebendazol ivermectin, vitamin D3 K2 magnesium citrate, curcumin, berberine, neem , apricot seeds, dandelion tea, green tea, apple, banana, alkaline water daily. Is there anything else which I can do for her.....
Once my mum had stage III Cancer - nothing could stop it - the antioxidants in green tea by itself didn't stop it - Cancer growth depends on high glucose blood levels and the general way to suppress cancer growth is to decrease the blood glucose/glutamine. The body has to be tricked to lower the glutamine levels. Reducing blood glucose level can be done by diet. When you grow old the Thymus glands shrinks and thus weakens the immune system which is why the immune system is not able to stop cancer growth.
Yes, green tea is one of the strategies that is helpful in the prevention and treatment of cancer. It should be combined with metabolic therapy as you described, as well as high dose intravenous vitamin C if tolerated. This is of course, not medical advice. Every treatment needs to be run by the training physician. The above treatments can of course also be combined with traditional treatments like chemotherapy or radiation therapy.
Yes, the Thymus gland does shrink with age which is where our T-cells come from. You can support this gland with grass fed thymus glandular desiccated pills. Dr. Berg recently talked about the thymus gland in his channel.
From the international journal of molecular science: Recently, in vitro experiments suggested that EGCG and its metabolites could reach the brain parenchyma through the blood-brain barrier and induce neuritogenesis. These results suggest that metabolites of EGCG may play an important role, alongside the beneficial activities of EGCG, in reducing neurodegenerative diseases.
@Dr Kuehne could you tell me how much EGCG I should take. I'm at the very beginning of my journey and havent even seen the oncology team yet. And should I take it intermittently?
I have not seen studies discussing the specific dose. Most manufacturers of green tea extract recommend 1800 mg daily, with 45% EGCG. This is not medical advice, of course and you should always ask your physician first. In general, though this is a dose that can be taken daily.
I’m so glad I found your channel today and without hesitation subscribed. 😉 I look forward to perusing your many videos. Curious if the Bigelow green tea is organic?
Is it important that it says ECGC or just green tea? And how much coffee is allowed, I found capsules from maybe two manufacturers, so I'm wondering how important it is to look at. Greeting💝
What is the ideal amount of green tea per day? I drink 2 cups of organic oolong greent tea a day. Should i drink more. Cancer survivor, serious about preventing recurrences.
In Japanese studies, they found that drinking 10 or more Japanese sized cups per day Showed a significant decrease in cancer rates. You could also consider supplementing with EGCG at the dose recommended by the manufacturer.
A common recommendation by the manufacturers for EGCG is 1800 mg of green tea extract daily which has 45% EGCG. There is not much research on appropriate dosing, but in general, the manufacturers will push for the highest dose within safety margins to sell as much of the product as possible.
White tea is an excellent choice. Very high in antioxidants. As for green tea, the Japanese studies generally showed people drinking upwards of 10 small cups daily.
Good morning, Dr. Kuehne, and greetings from Taipei, Taiwan! About green tea and prostate cancer: do you know of any scientific (or even anecdotal) evidence of green tea consumption either reducing a PSA number or stopping it from increasing? Thank you!
Hello to Taipei! Thank you for your comment. I have not seen literature specifically looking at a decrease in PSA from consuming green tea or its active ingredient EGCG. The supplements that help specifically for this are Saw Palmetto and Pygeum. Green tea can be however helpful in decreasing the risk of a variety of cancers.
@@danielvillarreal6610 "Anti-Cancer Effects of Green Tea Polyphenols Against Prostate Cancer" "3.1.,Therefore, first, we introduce the relationship between EGCG and tumor growth in PC. By using in vitro studies, many investigators have shown that EGCG suppressed tumor growth of androgen-sensitive (LNCaP and CWR22Rv1) and androgen-independent PC cells (DU-145 and PC-3 cells) in a dose-dependent manner [30,31,32,33,34,35]. In addition, another study showed that EGCG suppressed cell proliferation of androgen-sensitive LNCaP 104-S, androgen-independent LNCaP 104-R1, and androgen-adapted LNCaP R1Ad cells in both the presence and absence of androgen [36]. Furthermore, EGCG inhibited the growth of hormone-refractory C4-2 cells that were able to grow in hormone-free medium [35]. Data on the relationship between cell proliferation and EGC, ECG, or EC in PC in vitro are limited. However, EGCG, ECG, and EGC, but not EC, have been reported to have significant inhibitory effects on cell proliferation in DU145 cells [34]. Interestingly, the same study also showed that the suppressive effect was in the order ECG > EGCG > EGC [34]. Thus, a general agreement is that EGCG can inhibit the growth of PC cells regardless of androgen-dependency in vitro. More detailed studies are necessary to determine the anti-proliferative effect of other components of GTPs."
Thank you kindly! This is not an official recommendation, but I am using 600 to 1200 mg green tea extract standardized to 45% EGCG 5 days per week. I also have one to 2 cups of. Brewed green tea per day. If you take in too much, EGCG, it can become toxic to liver.
@@JonasKuehneMD your answers mean so much since I am trying to fight my prostate C holistically after going to MSK and they say that dietary intake has nothing to do with it nor can it affect it which is insane!
I am undergoing cancer therapy. Be careful people. If your undergoing cancer treatments, antioxidants protect all cells and do not discriminate, they will protect cancer cells as well, otherwise antioxidants are great for “prevention.”
@@JonasKuehneMD i noticed the picture of the supplement in three video says 1800 mg. The kind i got says take 1 but it’s only 400 mg that’s why I’m wondering if there’s certain amount that’s beneficial
It’s difficult to find exact doses in the literature. The study from Japan shows that 10 Japanese sized cups daily or more significantly lower risk of cancer. As it comes to EGCG supplements, most manufacturers recommend 1200-1800mg of green tea extract with 45% EGCG.
The EGCG supplement will be more concentrated. Some caution is advised because if you take too much it could cause liver damage. Green tea will have less, but it’s also safer.
One of the issues is weight loss without adequate calories. It certainly can be done, but would need to be at least discussed with a treating physician. If soft foods and purees are OK, there are certainly some possibilities. Also, protein shakes with heavy whipping cream will be calorically very dense.
@@stanleyyu2079 I hope your recovering brother, I too am fighting the shit , it isn't easy I know, many days I just fast as it is no food for cancer, but when I eat only low low carb to feed my body from getting too weak , protein and healthy fat select green super foods ,
My oncologist won't hear of anything about glutamine blocking. he said don't waste your time. I am changing doctors. I am stuck taking prednisone and want to fast but he thinks I will do immunotherapy again so he is giving prednisone to manage the immune induced hepatitis. it isn't working. help I want to start a but take egcg again. I am trying to find a doctor on my plan that will allow this. Perhaps just drinking a few cups of green tea per day will help?
I’m sorry to hear about your experience.In my opinion EGCG and berberine, a ketogenic diet, as well as weekly high dose vitamin c iv therapy (if G6PD is normal) can work complementary with low dose chemotherapy. of course you need to discuss any diet, supplements, or other modalities with your treating oncologist to make sure it is safe for you.
Hello Jonas, why is my comment cancelled? The man who suffered kidney failure because of excessive green tea consumption actually drank a lot. In Reuters it is reported as Ice tea neuphropathy due to excessive oxalate in the tea. I notice many below asking approximate dosage per day to be effective. Please at least give us this information as you describe the physiological part so well.
@@gotyoutriggered.8644 how so? Btw she's taking it for her phyllodes breast tumor. And drinking green tea would not suffice the cause...I don't want to stop them as they have anti-cancer properties. Is there any way to reduce the harm which you are talking about. Should I ask her to take it on alternate days...?..
@iconic1758 Almost all the issues with green tea and toxicity come from the pills. They are so high in consideration that they cause liver,kidney damage, and even death to a lot of people. She needs to needs to be getting liver and kidney checks every couple of months to make sure it's not affecting her negatively. I personally just drink multiple cups of loose leaf green tea. Loose leaf tea also lasts more than one brew. It's much safer, and you can easily cut back on consumption as needed after blood work or toxicity.
I was doubting if I must give protein powder with glutamine to my mother because she has stomach cancer. I don't know how to act because maybe she needs to improve her digestive tissue with glutamine or maybe she needs to fight cancerous cells with green tea. Some advices?
Cancer cells can only ferment glucose and glutamine. Glutamine is a non-essential amino acids that our own body produces. There are some supplements that decrease the uptake of glutamine. That couples with a ketogenic diet is essentially metabolic therapy and something that you could explore together with your treating physician. I did a video about this that you can find in my video library. Adding glutamine as a supplement may therefore not be advisable as again it is one of the only two substrates that cancer cells can use. One further treatment that is often used together with traditional treatments like chemotherapy is high dose, intravenous vitamin C it can kill cancer cells via production of hydrogen peroxide that cancer cells cannot break down. Studies have also shown that intravenous vitamin C can increase the effectiveness of chemotherapy and decrease its side effects. Again, any of these modalities should be discussed with the treating physician.
Toxico- and pharmacokinetic evidence further suggests internal dose of catechins is a key determinant in the occurrence and severity of hepatotoxicity. A safe intake level of 338 mg EGCG/day for adults was derived from toxicological and human safety data for tea preparations ingested as a solid bolus dose. An Observed Safe Level (OSL) of 704 mg EGCG/day might be considered for tea preparations in beverage form based on human AE data.
I would suggest you to try fenbendazole, ivermectin, curcumin, berberine, few apricot seeds, egcg supplement, dandelion tea.... And lots of exercise..... Try this for 10-15 days if it doesn't work then go for chemotherapy immediately
Your treating physician should work with you on several modalities that can improve your cancer. Many times this is a mix of traditional treatments, like chemotherapy and/or radiation therapy, together with nutritional therapy like metabolic therapy (ketogenic diet and glutamine lowering supplements) and additionally high dose vitamin C IV’s can be used as they can selectively kill cancer cells, but also decrease the side effects and increase the effectiveness of chemotherapy.
“Studies suggest that decaffeination can lead to a minor reduction in the levels of catechins and other antioxidants compared to regular green tea. While this decrease exists, decaf green tea still contains notable amounts of polyphenols and antioxidants, which contribute to its health-promoting properties.”
From NIH: In addition, EGCG has been shown to inhibit the expression of matrix metalloproteinases (MMPs) such as MMP9, which play a role in angiogenesis by degrading the extracellular matrix [24].
Radiation is usually targeted at deeper tissues where the tumors are present. The tissues that are passed on the way, and to get radiated benefit greatly from antioxidants. I’m not aware of contraindications here.
Plantains and beans are rich in carbs. It depends on what your dietary goals are. If you want to be on a ketogenic diet, then these two foods would not be good.
@JonasKuehneMD Thank you for your response. I am trying to get rid of bladder cancer that's why I asked. I don't know what else to eat since I have given up all other simple carbs. Fish and meat are expensive in my country and avocado isn't yet in season.
From the Web: Epigallocatechin gallate (EGCG), a flavonoid found in green tea, can inhibit glutamine metabolism and uptake, which can help prevent the growth and survival of cancer cells: Glutamine metabolism EGCG can inhibit glutaminase, an enzyme that plays a role in glutamine metabolism. EGCG can also inhibit glutamate dehydrogenase 1, which promotes the metabolism of glutamine and glutamate to generate ATP. Glutamine uptake EGCG can inhibit glutamine uptake, which can disrupt glutamine utilization. Tumor growth EGCG can inhibit the proliferation of cancer cells, such as MCF-7, LnCaP, and MDA-MB-231.
As far as I understood in several explanations, green tea blocks uptake of glutamine in most of all the cells, but, the cells can usually overcome that, it only has a very destructive effect on cancer cells because they are limited in their energy production capacity. Some suggest that this tea should not be used every day of the week. Therefore the expression press/pulse. Press glucose and pulse the glutamine to avoid harming other body functions.
Not necessarily. Your own body makes glutamine as it is a non-essential amino acid. For leaky gut I would suggest a gluten-free diet and glucosamine supplement
I have been taking it for year but I would say it not totally diminished there's still some risk imo. So you should cycle like 3-4 day on 400mg then 200mg for 3-4 day and occasionally one day off. And take some liver support like magnesium, NAC(this one need cycle otherwise you will get anhedonia), milk thistle, lycopene, cholorogenic acid.
@rupertbear9116 they combine very pleasantly. The better quality green tees don't have that bitter taste, in my taste- testing. I had a box of earl grey I wasn't fond of, mixed with a green tea bag it's quite good. I don't advise using 3 green tea bags at once to get your 3 for a day in. The tannins are too strong & it made me sick. If you use 2 tea bags, also make sure to use 2 big cups of water!
Glucose and glutamine are the main fuels. Cutting out glucose via a ketogenic diet and decreasing the uptake of glutamine through supplements or medication is essentially metabolic therapy. It is one of the modes that can be used to together with others to have a more successful outcome. It can, of course, be combined with chemotherapy and or high dose vitamin C infusions. It is important to discuss any of these modalities with your treating physician.
If inflammation is the product of the body's immune system attacking an infection, why should we be concerned about suppressing inflammation ... knowing that if the immune system is successful the inflammation will decrease naturally as the infection is mitigated ???
Short term inflammation after a workout or during an infection is helpful. Chronic prolonged inflammation is problematic and can cause disease initiation and progression.
@@JonasKuehneMD yes of course it’s multi factorial. But the title and video just clickbate adoes not provide that disclaimer but is misleading. Much of the research on the virtues of green tea is from China.
I love it BUT can we please start adding the fact that cancer cells can also survive on a ketogenic diet/ without glucose consumption? They can adapt their metabolism to fit even ketones (I guess this is not true for all cancers, but still). I always hear the basic point of "cancer eats glucose" but it's not that simple! Still keto has many benefits.
You are correct, it is not that simple. The two main fuels of cancer cells are glucose and glutamine. The theory that cancer can evolve to feed on ketones has not been proven as far as I’m aware. This is because the mitochondria are defective in cancer cells. Fermentation seems to be the only way to generate energy.
@@nikesonmyfeet1234I worded it wrong but the point still stands. Cancer can survive on a keto diet. If it wouldn’t, everyone on keto would survive indefinitely which they don’t. It’s not my duty to present papers for you. The fact I stated stands and that’s all I’m gonna say. If you can’t work with that it’s your problem
Interesting topic. Fenbendazole and ivermectin have sparked scientific research due to their anti-cancer properties. UA-cam is currently strictly regulating this space.
FYI This is a very good research paper detailing fenbendazole anticancer properties including inhibition of glucose uptake, tumor suppressor p53 activation, cell arrest, and apoptosis. Don't take Tylenol while on fenbendazole. "Fenbendazole acts as a moderate microtubule destabilizing agent and causes cancer cell death by modulating multiple cellular pathways" ...Simultaneously, it caused mitochondrial translocation of p53 and effectively inhibited glucose uptake, expression of GLUT transporters as well as hexokinase (HK II) - a key glycolytic enzyme that most cancer cells thrive on... ...In this study, we show that fenbendazole (FZ) exhibits a moderate microtubule depolymerizing activity towards human cancer cells, but possesses a potent antitumor effect as evident from in vitro and in vivo experiments. Our results indicate that FZ exerts its antitumor effect through the disruption of microtubule dynamics, p53 activation and the modulation of genes involved in multiple cellular pathways. FZ treatment also resulted in reduced glucose uptake in cancer cells due to down regulation of GLUT transporters and key glycolytic enzymes.
Thank you for the feedback. I agree, sometimes they get a bit longer. I usually opt for around 10 minutes but if it’s an exciting topic with a lot of information, I might run a bit longer.
@@saganspirit I can watch a lot of videos in 20 minutes and the vast majority of people on UA-cam and on social media in general skip videos who are more than 10 minutes long
@@JonasKuehneMD That does not mean it's a scientific fact, you as MD must know this. You can probably fool alot of people, but you cant fool the ones who know how science works.
At least he started on the dot no rumbling or intros so you should highlight that. Some audiences actually have problems with short videos, they like longer videos. Jonas this was excellent ❤😊
Jonas thank you for your clear and thorough explanations. I understand that some folks consider that your presentations are too long but I very much appreciate the thorough descriptions of biochemical mechanism involved and scientific publication references.
Thank you so much! I always try to make the scientific background of a topic more digestible and present it in a way that makes sense to me as well.
@@JonasKuehneMD It does help in my understanding that I have a medical science background with particular interest in biochemistry and microbiology. My main interest is to help my partner who is in remission from breast cancer and my friend and former colleague who is stage 4 breast cancer in the lungs and about to restart treatment. I came across Dr Seyfried in my research but even though I understood what he was saying, it wasn’t convincing enough to share with folks without much basic background knowledge. By contrast your presentations are distilled and much easier to follow. Thank you!
@lucdelhaize4029 Please share your wife protocol to stay cancer free. I'm also breast cancer
@@JonasKuehneMDsk8jsi4ig9jesdjgy8f8djudy08girjgyyhgy7dyfeo99jeses5segg55
@@lucdelhaize4029 Consider looking into diindolylmethane, curcumin phytosomes, Artemisinin, some BC patients are taking 2 to 3 thousand mg melatonin/day, investigate Brio Medical for their protocols.
It’s fantastic to hear an MD embrace metabolic/mitochondrial dysfunction as the cause of CA rather than genetics/environment.
Thank you for your kind words. It is still worrisome to me that many oncologists refuse to explore the abundant research on this topic. My explanation is that they are trained well by the medical establishment and pharmaceutical industry not to venture off into areas that are less lucrative.
@@JonasKuehneMD it seems that most oncologists are resigned to the idea that most of their patients will be dead within a few years and their job is to keep them busy with ineffective cancer treatments until they pass away, to keep their minds off their impending doom until they are very near death.
@@JonasKuehneMD Exactly ! Keep in consideration that , in Europe, doctors MUST follow Protocols officially approved . And, actually , those Protocols do not target Metabolism dysfunctions (Mitocondria). Very sad...
@@JonasKuehneMD I've read green tea extract can destroy ur liver and kill u
Another reason to enjoy my daily cup of matcha!
Yes!!
Thank you for your information. I couldn’t agree more as my husband is “dealing with” prostate cancer and following the metabolic protocol. The only thought I’d add is, “Good luck finding an oncologist who believes in any of this mumbo jumbo!” I just walked out of our oncologist’s office a couple of weeks ago because of his mocking, knowing it all attitude. I will never return. Dr Seyfried is a hero and I pray that the medical world will wake up one day…but I doubt it.
I’m very sorry to hear that. This reaction of your physician is the reflection of the pharma industry. Oncologist should know that cutting out sugars and decreasing glutamine can be immensely helpful. I have a had patient that had done metabolic therapy in combination with high dose intravenous vitamin C weekly. He only required very low doses of chemo and for a short time only.
@@JonasKuehneMDWhere can someone get this treatment, metabolic therapy? Germany?
p.s. Can someone get vitamins C without glucose, fructose etc?
Great question.
Prostate cancer is very pernicious, the urologists are butchers, they use a meat cleaver when they should be using a scalpel. Prevention is key gotta drive insulin to baseline by going 0 carb, the continual insulin spikes over a long period of time are extremely dangerous and our urologists need to stress this but the will not because they benefit from our misery.
@@JonasKuehneMD2:51
Known this for 30 years. Dink six tea bags daily. I am 60 and look 40. A friend of mine killed his prostrate cancer with 10 cops per day.
👍
Would help with blood cancers ?
It helps with all cancers.@@Desiree-Rojas
Thank you for this essential information. I appreciate your thorough explanation. I did not think it was too long. 💞
Thank you!
Excellent video, i like your approach. i look forward to more of your videos.
Awesome, thank you!
@@JonasKuehneMD btw I just noticed you are from Los Angeles. I have a friend who has recently been diagnosed with leukemia last month and is now currently doing chemo and it's pretty brutal. Are there an doctors in Los Angeles area that you know of that specialize in treatment that doesn't involve chemo and instead targets diet and less harsh medications? She's only 43, but I feel like there are better options than doing just chemo. Thanks in advance
Just had the thought that he reminds me of Arnold. He's the cancer terminator.
Could you make a video about Berberine and one about Fenbendazole?
I'll show you in 1️⃣ what Burbon did for me 🤮
What..?@@rhombifer566
And Mebendazole supposedly easier to cross the brain barrier for those with brain tumours, and how to protect our livers when taking these supplements.
@@GillyMountford milk thistle but not for hormone positive breast cancer...
EGCG and Curcumin synergize against Leukemia.
And Resveratrol and Quercetin synergize against Leukemia, Trans Resveratrol stabilized and Quercetin Phytosomes are possibly more effective.
Thank you so much for posting reliable references to support your points. It is much appreciated.
Glad it was helpful!
Thanks. Excellent information to consider.
11:32 green tea blocking glutamine In combination RSO/FSO cannabis oil treatment and prevention spreads or reoccurrence?
Could you rephrase that ?
Dr. Thank you so much. VERY good comprehensive video on EGCG.
To be clear, does EGCG prevent glutamine uptake into ONLY cancer cells? Or both normal & cancer cells? How would this effect recovery from exercise?
TYIA
EGCG decrease uptake by all cells. Healthy cells are not negatively affected by this, however cancer cell depending on glutamine fermentation are.
@@JonasKuehneMD okay TY!
Suzanne Somers wrote books on Cancer. She had breast cancer. But cancer finally did kill her. So many studies are done and what works for some doesn't always work for others
That is very true. I think it’s important to attack the disease from different angles. Therefore, metabolic therapy, mixed with supplements like green tea or berberine is a good start.
I believe Suzanne summers lived 20 years with breast cancer. It's possible she would have died much sooner without her nutrition and natural remedies. I know several people who did not do chemo and other mainstream treatments and did alternate treatments. All have died but lived MUCH longer than the doctors said they would with regular treatments. My wife's grandmother was given maybe a year if she did surgery and chemo. She did natural stuff and nutrition and lived 7 years
@@kennygee2715 Suzanne sommers had done chemotherapy. There is no one shoe fits all. I know many people who done chemo and are living today a normal life, and others I know that died. Don't look one way when you cross the street you will certainly get hit by a car. All bodies need the right foods, exercise on a daily basis. Fruits vegetables, nuts and some fish and some meat limited. Science plays a very large role in our lives and so does nutrition. If it were not for the advancement of medicine we would not be living as long. I only look at facts not fiction
@JonasKuehneMD hey what all comes under metabolic therapy. My mother is phyllodes breast tumor.. I'm giving her mebendazol ivermectin, vitamin D3 K2 magnesium citrate, curcumin, berberine, neem , apricot seeds, dandelion tea, green tea, apple, banana, alkaline water daily. Is there anything else which I can do for her.....
@@JonasKuehneMDhey what all comes under metabolic therapy. My mother is having phyllodes breast tumor...with p53 mutant gene
Outstanding presentation!
Thank you kindly!
Once my mum had stage III Cancer - nothing could stop it - the antioxidants in green tea by itself didn't stop it - Cancer growth depends on high glucose blood levels and the general way to suppress cancer growth is to decrease the blood glucose/glutamine. The body has to be tricked to lower the glutamine levels. Reducing blood glucose level can be done by diet. When you grow old the Thymus glands shrinks and thus weakens the immune system which is why the immune system is not able to stop cancer growth.
Yes, green tea is one of the strategies that is helpful in the prevention and treatment of cancer. It should be combined with metabolic therapy as you described, as well as high dose intravenous vitamin C if tolerated. This is of course, not medical advice. Every treatment needs to be run by the training physician.
The above treatments can of course also be combined with traditional treatments like chemotherapy or radiation therapy.
Yes, the Thymus gland does shrink with age which is where our T-cells come from. You can support this gland with grass fed thymus glandular desiccated pills. Dr. Berg recently talked about the thymus gland in his channel.
What type of green tea is better? Macha green tea, or Jasmine tea (green tea) & any green tea leaves?
Matcha appears to have a higher EGCG content, but also higher caffeine content
Thank you! ❤
@@JonasKuehneMDso which one to choose, please suggest one for lung cancer stage 4
@@Dataenginnermatcha or an organic green, take a variety
Many thanks for your explanation which can be understood
🙏❤️
8:28 does it pass the blood brain barrier to kill brain tumors and meningioma tumors??
From the international journal of molecular science:
Recently, in vitro experiments suggested that EGCG and its metabolites could reach the brain parenchyma through the blood-brain barrier and induce neuritogenesis. These results suggest that metabolites of EGCG may play an important role, alongside the beneficial activities of EGCG, in reducing neurodegenerative diseases.
Hi can you recommend a which green tea to buy
@Dr Kuehne could you tell me how much EGCG I should take. I'm at the very beginning of my journey and havent even seen the oncology team yet. And should I take it intermittently?
I have not seen studies discussing the specific dose. Most manufacturers of green tea extract recommend 1800 mg daily, with 45% EGCG.
This is not medical advice, of course and you should always ask your physician first. In general, though this is a dose that can be taken daily.
Search cancer care by Paul Marik, he lists the best dosage. His paper is 227 pages, a lot of good information.
Hey how much egcg supplement is safe on a regular basis?..
THANKS FROM AUSTRALIA
You are very welcome. Thank you for joining the channel from down under.
Thank you Dr great explanation.
Glad it was helpful!
@@JonasKuehneMD I’ve been drinking green tea ever since I watched your advice Dr Jonas… thank you very much.
I’m so glad I found your channel today and without hesitation subscribed. 😉 I look forward to perusing your many videos. Curious if the Bigelow green tea is organic?
Thank you so much! Bigelow has an organic green tea, but it needs to state so on the package. They also have commercial non-organic green tea.
@@JonasKuehneMD Shouldn’t teas be organic due to pesticide contamination?
@@JonasKuehneMD
What do you think about Metformin to decrease glutamine levels. I drink green and I also take extract.
Yes, metformin can help to lower glutamine uptake.
Thanks very much for the eccellent information.
Glad it was helpful!
Is it important that it says ECGC or just green tea? And how much coffee is allowed, I found capsules from maybe two manufacturers, so I'm wondering how important it is to look at. Greeting💝
*coffein in capsules
*EGCG😂
It should say EGCG as this is the active ingredient in green tea. 2-3 cups of coffee per day should be OK.
@@JonasKuehneMD thank you!💝
@6:25 Green tea makes the cell commit "Hari Carri". I guess Matcha (Japanese green tea) would work better 😂.
great info .... thank you
🙏❤️
Matcha😊
What is the ideal amount of green tea per day? I drink 2 cups of organic oolong greent tea a day. Should i drink more. Cancer survivor, serious about preventing recurrences.
In Japanese studies, they found that drinking 10 or more Japanese sized cups per day Showed a significant decrease in cancer rates. You could also consider supplementing with EGCG at the dose recommended by the manufacturer.
🍵🤔
How about the recommended dosages when you want to fight active cancer? I mean, at what dosages we are speaking about actively fighting cancer?
A common recommendation by the manufacturers for EGCG is 1800 mg of green tea extract daily which has 45% EGCG.
There is not much research on appropriate dosing, but in general, the manufacturers will push for the highest dose within safety margins to sell as much of the product as possible.
Dr. William Li has done a lot of testing on green teas, & all others. Watch his videos.
I wonder if a little is good, is more better? I drink white tea which is the white leaves of the green tea plant.
White tea is an excellent choice. Very high in antioxidants. As for green tea, the Japanese studies generally showed people drinking upwards of 10 small cups daily.
@@JonasKuehneMD wow I’d never get to sleep! lol maybe will look into supplementing with EGCG. Great channel!
Japanese use very small tea cups.
Dr. William Li tested many teas. Combining green & black tea together doubles their potency.
Good morning, Dr. Kuehne, and greetings from Taipei, Taiwan! About green tea and prostate cancer: do you know of any scientific (or even anecdotal) evidence of green tea consumption either reducing a PSA number or stopping it from increasing? Thank you!
Hello to Taipei! Thank you for your comment. I have not seen literature specifically looking at a decrease in PSA from consuming green tea or its active ingredient EGCG. The supplements that help specifically for this are Saw Palmetto and Pygeum. Green tea can be however helpful in decreasing the risk of a variety of cancers.
@@JonasKuehneMD Thank you!
@@danielvillarreal6610
"Anti-Cancer Effects of Green Tea Polyphenols Against Prostate Cancer"
"3.1.,Therefore, first, we introduce the relationship between EGCG and tumor growth in PC. By using in vitro studies, many investigators have shown that EGCG suppressed tumor growth of androgen-sensitive (LNCaP and CWR22Rv1) and androgen-independent PC cells (DU-145 and PC-3 cells) in a dose-dependent manner [30,31,32,33,34,35]. In addition, another study showed that EGCG suppressed cell proliferation of androgen-sensitive LNCaP 104-S, androgen-independent LNCaP 104-R1, and androgen-adapted LNCaP R1Ad cells in both the presence and absence of androgen [36]. Furthermore, EGCG inhibited the growth of hormone-refractory C4-2 cells that were able to grow in hormone-free medium [35].
Data on the relationship between cell proliferation and EGC, ECG, or EC in PC in vitro are limited. However, EGCG, ECG, and EGC, but not EC, have been reported to have significant inhibitory effects on cell proliferation in DU145 cells [34]. Interestingly, the same study also showed that the suppressive effect was in the order ECG > EGCG > EGC [34]. Thus, a general agreement is that EGCG can inhibit the growth of PC cells regardless of androgen-dependency in vitro. More detailed studies are necessary to determine the anti-proliferative effect of other components of GTPs."
Awesome channel! Recommended daily dose?
Thank you kindly! This is not an official recommendation, but I am using 600 to 1200 mg green tea extract standardized to 45% EGCG 5 days per week. I also have one to 2 cups of. Brewed green tea per day. If you take in too much, EGCG, it can become toxic to liver.
@@JonasKuehneMD your answers mean so much since I am trying to fight my prostate C holistically after going to MSK and they say that dietary intake has nothing to do with it nor can it affect it which is insane!
1 green tea in the morning, one in the evening?
How much ECGC? When?
How much Berberine?
What do you think about Fenbendazol?
I cannot drink green tea in the evening due to the caffeine. I will have two green teas in the earlier part of the day.
@@JonasKuehneMDgreen tea contain caffeine? I thought it doesn't......
@@iconic1758 Get organic decaffeinated Sencha green tea. I buy this in loose form from Fraser Tea.
@@iconic1758all tea does...
Do you just take the suggested serving size on the bottle for EGCG?
That’s what I would go with. Usually their recommendation is pretty good.
I am undergoing cancer therapy. Be careful people. If your undergoing cancer treatments, antioxidants protect all cells and do not discriminate, they will protect cancer cells as well, otherwise antioxidants are great for “prevention.”
Thank you for your comment. Are you adding metabolic therapy to your treatment regiment?
How many mgs should you take of ECGC?
I would follow the manufacturers recommendation. In higher amounts, it can be damaging to the liver.
@@JonasKuehneMD i noticed the picture of the supplement in three video says 1800 mg. The kind i got says take 1 but it’s only 400 mg that’s why I’m wondering if there’s certain amount that’s beneficial
How much green tea do you need for it to become effective ?
It’s difficult to find exact doses in the literature. The study from Japan shows that 10 Japanese sized cups daily or more significantly lower risk of cancer. As it comes to EGCG supplements, most manufacturers recommend 1200-1800mg of green tea extract with 45% EGCG.
Thank you. I drink a lot of green tea already but that's probably a bit much. I think some form of supplement on top of this woukd probably help then
Dr. Kuehne, is it true that when we eat carbohydrates, our need for vitamin B1 goes up?
Thiamine is needed in carbohydrate metabolism, so a certain daily amount is required.
@@JonasKuehneMD OK, thank you.
is drinking Matcha daily the best form if ingesting this? or is via pill extract a better way to get more potent dosage?
The EGCG supplement will be more concentrated. Some caution is advised because if you take too much it could cause liver damage. Green tea will have less, but it’s also safer.
For someone with oral cancer with no solid foods, is it hard to go on keto diet?
One of the issues is weight loss without adequate calories. It certainly can be done, but would need to be at least discussed with a treating physician. If soft foods and purees are OK, there are certainly some possibilities. Also, protein shakes with heavy whipping cream will be calorically very dense.
Thank you for your quick response and sharing your knowledge.
Scramble eggs ground beef,canned fish all sort I eat daily no teeth, if your unable at all many creams, oils could be drank
@@daleval2182 Thanks for sharing.
@@stanleyyu2079 I hope your recovering brother, I too am fighting the shit , it isn't easy I know, many days I just fast as it is no food for cancer, but when I eat only low low carb to feed my body from getting too weak , protein and healthy fat select green super foods ,
My oncologist won't hear of anything about glutamine blocking. he said don't waste your time. I am changing doctors. I am stuck taking prednisone and want to fast but he thinks I will do immunotherapy again so he is giving prednisone to manage the immune induced hepatitis. it isn't working. help I want to start a but take egcg again. I am trying to find a doctor on my plan that will allow this. Perhaps just drinking a few cups of green tea per day will help?
I’m sorry to hear about your experience.In my opinion EGCG and berberine, a ketogenic diet, as well as weekly high dose vitamin c iv therapy (if G6PD is normal) can work complementary with low dose chemotherapy. of course you need to discuss any diet, supplements, or other modalities with your treating oncologist to make sure it is safe for you.
@@JonasKuehneMD Thank you for that. Chemo means immunotherapy too yes?
Stop telling your Dr & drink what you Want: green tea all day!
You don't need a doctor's permission to take green tea, EGCG or anything else that you want to.
Hello Jonas, why is my comment cancelled? The man who suffered kidney failure because of excessive green tea consumption actually drank a lot. In Reuters it is reported as Ice tea neuphropathy due to excessive oxalate in the tea. I notice many below asking approximate dosage per day to be effective. Please at least give us this information as you describe the physiological part so well.
My mom is taking egcg capsules on a daily basis. Is this harmful? Will it lead to stones or renal failure??
@iconic1758 Taking capsules can be dangerous. You have a way lower risk of drinking the tea.
@@gotyoutriggered.8644 how so? Btw she's taking it for her phyllodes breast tumor. And drinking green tea would not suffice the cause...I don't want to stop them as they have anti-cancer properties. Is there any way to reduce the harm which you are talking about. Should I ask her to take it on alternate days...?..
@iconic1758 Almost all the issues with green tea and toxicity come from the pills. They are so high in consideration that they cause liver,kidney damage, and even death to a lot of people. She needs to needs to be getting liver and kidney checks every couple of months to make sure it's not affecting her negatively. I personally just drink multiple cups of loose leaf green tea. Loose leaf tea also lasts more than one brew. It's much safer, and you can easily cut back on consumption as needed after blood work or toxicity.
I was doubting if I must give protein powder with glutamine to my mother because she has stomach cancer. I don't know how to act because maybe she needs to improve her digestive tissue with glutamine or maybe she needs to fight cancerous cells with green tea. Some advices?
Cancer cells can only ferment glucose and glutamine. Glutamine is a non-essential amino acids that our own body produces. There are some supplements that decrease the uptake of glutamine. That couples with a ketogenic diet is essentially metabolic therapy and something that you could explore together with your treating physician. I did a video about this that you can find in my video library. Adding glutamine as a supplement may therefore not be advisable as again it is one of the only two substrates that cancer cells can use. One further treatment that is often used together with traditional treatments like chemotherapy is high dose, intravenous vitamin C it can kill cancer cells via production of hydrogen peroxide that cancer cells cannot break down. Studies have also shown that intravenous vitamin C can increase the effectiveness of chemotherapy and decrease its side effects. Again, any of these modalities should be discussed with the treating physician.
@@JonasKuehneMD thank you very much for your detailed answer. I'll see also the video you mention.
Can dialysis patients take this supplement with active cancer?
In my opinion yes, but you should discuss any supplements with your oncologist first.
What dosage is needed please?
Most manufacturers recommend between 1200 and 1800 mg of 75% EGCG. This is not medical advice. There are some liver issues at high amounts.
@@JonasKuehneMD Thank you.
Toxico- and pharmacokinetic evidence further suggests internal dose of catechins is a key determinant in the occurrence and severity of hepatotoxicity. A safe intake level of 338 mg EGCG/day for adults was derived from toxicological and human safety data for tea preparations ingested as a solid bolus dose. An Observed Safe Level (OSL) of 704 mg EGCG/day might be considered for tea preparations in beverage form based on human AE data.
@@stanleyyu2079 Thank you vey much, Very helpful.
@@deborahcollard4560 You are very welcome!
How to cure my uterine cancer? 😢
I would suggest you to try fenbendazole, ivermectin, curcumin, berberine, few apricot seeds, egcg supplement, dandelion tea.... And lots of exercise..... Try this for 10-15 days if it doesn't work then go for chemotherapy immediately
Your treating physician should work with you on several modalities that can improve your cancer. Many times this is a mix of traditional treatments, like chemotherapy and/or radiation therapy, together with nutritional therapy like metabolic therapy (ketogenic diet and glutamine lowering supplements) and additionally high dose vitamin C IV’s can be used as they can selectively kill cancer cells, but also decrease the side effects and increase the effectiveness of chemotherapy.
Can you just put the dry tea in a smoothie?
It probably would not taste very good.
@@JonasKuehneMD I do it all the time and it is tasteless but is it as effective?
Empty stomach the best.
See summary in Figure 2.
"Epigallocatechin-3-gallate (EGCG) for Clinical Trials: More Pitfalls than Promises?"
Is decaf green tea good
“Studies suggest that decaffeination can lead to a minor reduction in the levels of catechins and other antioxidants compared to regular green tea. While this decrease exists, decaf green tea still contains notable amounts of polyphenols and antioxidants, which contribute to its health-promoting properties.”
How does EGCG block angiogenesis?
From NIH:
In addition, EGCG has been shown to inhibit the expression of matrix metalloproteinases (MMPs) such as MMP9, which play a role in angiogenesis by degrading the extracellular matrix [24].
@@JonasKuehneMD Danke, Herr Doktor
Why didn’t Dr Sefried try Pet scan with glutamine??
He was able to establish that glutamine was used as a substrate for fermentation. I am not sure how he designed his research protocols.
Why would you give radioactive ☢️ glucose to a cancer patient ? Okay any that like giving a mega dose of food to the cancer ?
Does matcha tea have EGCG
Yes, it does. EGCG is in all green teas.
Do you recommend green tea with radiation?? Since green tea is an anti oxidant
Radiation is usually targeted at deeper tissues where the tumors are present. The tissues that are passed on the way, and to get radiated benefit greatly from antioxidants. I’m not aware of contraindications here.
I will be getting some green tea but can I keep eating unripe plantain and beans? I have already cut out carbs and I fast 16:8 daily.
Plantains and beans are rich in carbs. It depends on what your dietary goals are. If you want to be on a ketogenic diet, then these two foods would not be good.
@JonasKuehneMD Thank you for your response. I am trying to get rid of bladder cancer that's why I asked. I don't know what else to eat since I have given up all other simple carbs. Fish and meat are expensive in my country and avocado isn't yet in season.
@@Bloomfushion how about eggs?
@@BloomfushionMetabolic therapy requires calorie restricted high fat ketogenic diet with gki of 1 or below to be effective.
@@stanleyyu2079 OK, I will add eggs. Anything else please?The only nuts available in my country are peanuts and cashew nuts.
Healthy but what about all the fluoride in EGCG?!
The amount of fluoride and green tea may be slightly higher than in black tea, but still very low, and in my opinion does not post a significant risk.
EGCG “blocks the uptake of glutamine “. In just cancer cells…… or ALL cells?
From the Web:
Epigallocatechin gallate (EGCG), a flavonoid found in green tea, can inhibit glutamine metabolism and uptake, which can help prevent the growth and survival of cancer cells:
Glutamine metabolism
EGCG can inhibit glutaminase, an enzyme that plays a role in glutamine metabolism. EGCG can also inhibit glutamate dehydrogenase 1, which promotes the metabolism of glutamine and glutamate to generate ATP.
Glutamine uptake
EGCG can inhibit glutamine uptake, which can disrupt glutamine utilization.
Tumor growth
EGCG can inhibit the proliferation of cancer cells, such as MCF-7, LnCaP, and MDA-MB-231.
As far as I understood in several explanations, green tea blocks uptake of glutamine in most of all the cells, but, the cells can usually overcome that, it only has a very destructive effect on cancer cells because they are limited in their energy production capacity.
Some suggest that this tea should not be used every day of the week. Therefore the expression press/pulse.
Press glucose and pulse the glutamine to avoid harming other body functions.
Does EGCG cause liver damage?
At high amounts, it can cause elevated liver enzymes.
So glutamine supplement , for leaky gut, isnt a good idea, i take it.
Not necessarily. Your own body makes glutamine as it is a non-essential amino acid.
For leaky gut I would suggest a gluten-free diet and glucosamine supplement
I took it extensively ended up with colon cancer
White tea?
Also great choice, but I am not sure about the concentration of EGCG here.
If I take 200mg-400mg per day, are my risk of liver issues are diminished?
I cannot give any medical advice on this platform. In my experience that is a reasonable dose
Hey how much are you taking now? My mom is taking 250 mg egcg ....in a supplement.
I have been taking it for year but I would say it not totally diminished there's still some risk imo. So you should cycle like 3-4 day on 400mg then 200mg for 3-4 day and occasionally one day off. And take some liver support like magnesium, NAC(this one need cycle otherwise you will get anhedonia), milk thistle, lycopene, cholorogenic acid.
Watch out for liver pain, jaundice and eye color change.
But if you take it with food then you can take 400mg daily because food significantly decrease egcg absorption.
i don't like green tea, but i love black tea.
Also a good choice, but green tea has more EGCG
@@JonasKuehneMD can you do a follow-up video on any research on the anti-cancer effects (if any) of black tea?
Dr. William Li says to combine the 2 & they're more than twice Effective!!
@@liberty8424 thanks. but will the black tea mask the foul taste of the green tea?
@rupertbear9116 they combine very pleasantly. The better quality green tees don't have that bitter taste, in my taste- testing. I had a box of earl grey I wasn't fond of, mixed with a green tea bag it's quite good. I don't advise using 3 green tea bags at once to get your 3 for a day in. The tannins are too strong & it made me sick.
If you use 2 tea bags, also make sure to use 2 big cups of water!
I don’t have my spleen, so I have that going against me.
Large amounts of green tea or EGCG can be difficult for the liver. A few cups of green tea or a moderate dose of a supplement should still be OK.
This is not all correct.
Cancer also uses iron.
Everything we eat actually turns into glucose, and our body produces glutathione naturally.
Glucose and glutamine are the main fuels. Cutting out glucose via a ketogenic diet and decreasing the uptake of glutamine through supplements or medication is essentially metabolic therapy. It is one of the modes that can be used to together with others to have a more successful outcome. It can, of course, be combined with chemotherapy and or high dose vitamin C infusions. It is important to discuss any of these modalities with your treating physician.
If inflammation is the product of the body's immune system attacking an infection, why should we be concerned about suppressing inflammation ... knowing that if the immune system is successful the inflammation will decrease naturally as the infection is mitigated ???
Short term inflammation after a workout or during an infection is helpful. Chronic prolonged inflammation is problematic and can cause disease initiation and progression.
Essiac tea
Well China and South Korea has very high rates of cancer. And both countries consume a lot of green tea. So green tea is not a panacea for cancer
There may of course, be other factors that increase the rate of cancer in these countries disproportionately
@@JonasKuehneMD yes of course it’s multi factorial. But the title and video just clickbate adoes not provide that disclaimer but is misleading. Much of the research on the virtues of green tea is from China.
@@JonasKuehneMDtons of reasons!!! It’s China!😮
Just don't take your Iron with it--- made that mistake tonight!!
Good tip
I love it BUT can we please start adding the fact that cancer cells can also survive on a ketogenic diet/ without glucose consumption?
They can adapt their metabolism to fit even ketones (I guess this is not true for all cancers, but still).
I always hear the basic point of "cancer eats glucose" but it's not that simple!
Still keto has many benefits.
You are correct, it is not that simple. The two main fuels of cancer cells are glucose and glutamine. The theory that cancer can evolve to feed on ketones has not been proven as far as I’m aware. This is because the mitochondria are defective in cancer cells. Fermentation seems to be the only way to generate energy.
NO Cancer can feed on ketones man wrong, it can't ferment it, not possible
Cite your research paper showing cancer uses ketones
@@nikesonmyfeet1234I worded it wrong but the point still stands. Cancer can survive on a keto diet. If it wouldn’t, everyone on keto would survive indefinitely which they don’t.
It’s not my duty to present papers for you. The fact I stated stands and that’s all I’m gonna say.
If you can’t work with that it’s your problem
@@LorettaBangBang Except for the fact that it’s not a fact.
Hernandez Dorothy Walker Sandra Taylor Helen
Buy Matcha from Japan, NOT CHINA!!!
And NOT in a bag, but Eco powder!
And organic.
Can you talk about
🚩FENBENDAZOLE🚩
Interesting topic. Fenbendazole and ivermectin have sparked scientific research due to their anti-cancer properties. UA-cam is currently strictly regulating this space.
Joe Tippens fenbendazole QA session,
ua-cam.com/video/Z6_UISKdrto/v-deo.html
FYI
This is a very good research paper detailing fenbendazole anticancer properties including inhibition of glucose uptake, tumor suppressor p53 activation, cell arrest, and apoptosis.
Don't take Tylenol while on fenbendazole.
"Fenbendazole acts as a moderate microtubule destabilizing agent and causes cancer cell death by modulating multiple cellular pathways"
...Simultaneously, it caused mitochondrial translocation of p53 and effectively inhibited glucose uptake, expression of GLUT transporters as well as hexokinase (HK II) - a key glycolytic enzyme that most cancer cells thrive on...
...In this study, we show that fenbendazole (FZ) exhibits a moderate microtubule depolymerizing activity towards human cancer cells, but possesses a potent antitumor effect as evident from in vitro and in vivo experiments. Our results indicate that FZ exerts its antitumor effect through the disruption of microtubule dynamics, p53 activation and the modulation of genes involved in multiple cellular pathways. FZ treatment also resulted in reduced glucose uptake in cancer cells due to down regulation of GLUT transporters and key glycolytic enzymes.
You will get more views if you make your videos shorter. Good content
Thank you for the feedback. I agree, sometimes they get a bit longer. I usually opt for around 10 minutes but if it’s an exciting topic with a lot of information, I might run a bit longer.
It's only 20 minutes
@@saganspirit I can watch a lot of videos in 20 minutes and the vast majority of people on UA-cam and on social media in general skip videos who are more than 10 minutes long
@@قناةلنشرالخير-ص3ل Hard to believe that people used to spend hours reading books...........
@@قناةلنشرالخير-ص3ل Hard to believe people used to spend an hour+ reading books.........
There is not enough evidence for this, stop spreading misinformation, for views!
All the studies are attached in the description.
@@JonasKuehneMD That does not mean it's a scientific fact, you as MD must know this. You can probably fool alot of people, but you cant fool the ones who know how science works.
You weren’t listening
@@davidreleplenty of evidence, what nonsense are you spouting here
@@jchneo26 Where are the research papers, that show consistency and reproducibility of these results. I'll wait.
Thanks for the information, but please shorten your video to 10 minutes or less. No disrespect.
Appreciate the input!
At least he started on the dot no rumbling or intros so you should highlight that. Some audiences actually have problems with short videos, they like longer videos. Jonas this was excellent ❤😊
Perfect video in my opinion. 🙌 you just can't get the right information in tictok bites. 🤷🏼♀️
Very good input
Very informative foe people who are new to this! ❤