I think there may have been an error with conversion of Folic acid > DHF >THF. You mentioned they require Vitamin C. As far as I can find, the cofactor for these conversions is not vitamin C but NADPH. Vitamin C is mainly for certain hydroxylation reactions involving a metalloenzyme, like Dopamine > Norepinephrine. DHF to THF is just a reduction reaction, not a hydroxylation. The only relationship I can find between Vit C and Folate is that Vit C helps prevent oxidation of Folate/THF helping it stay reduced.
I'm by God's healthy 65yrsold and been dignoisnode in march with parkinson I. Recently been taking folate because of a article saying its a cure for parkinson iv noticed a decrease in my inflamationcan you tell me anything new on it please and thank you for this video
Awesome description doctor . Thank you so much. My mother has aplastic anemia from 2014. From few works ago, she got a muscular pain and also warming muscles.. What i need to know is, these symptoms are of hyperdynamic cirulatory?? I so that the anemia may cause to hyperdynamic circulatory. Thank you
@@Kimmy1412 it's ok you're not intruding. MTHFR is a problem with converting folate and folic acid to be used by the body do to a mutation. It can range from 20% to 80% reduction. In my case im homozygous with the mutation getting the gene from both my parents because of that im 75% reduced in my ability to absorb B9. I know the simple summary of it, but not the deeply technical parts of it.
@@MedicosisPerfectionalis im normally well, i usually have to take a supplement called L-Methylfolate. Before I was prescribed the medication, the doctors noticed my extremely high homocysteine levels and low blood count and told me that the supplement skips the part that is damaged. And ive always wondered about how the methlation process which you already talked about in this video, but what about foods you should or should not avoid, does it matter? And what happens to the unconverted B9 in my body? Does it hurt my kidneys or liver?
Hey Medicosis Perfectionalis, I know it's two years late... But I'm very interested in "fermentation residue factor". Do you know where that name might have come from? Thanks for the video!
Sir I'm confused with folic acid .. Is folic acid vitamin B9 or vitamin B11??? Please answer..... Some books have name vitamin B11 and some have B9 witch is correct one ... Please answer...
If there's b-12 deficiency, b-9 can't donate its methyl to b-12. This way, which one should be treated first? I feel b-12. But i need your answer. Thanks for this wonderful video. I have recently been diagnosed with B-9 deficiency (serum 0.44 ng) and B-12 insufficiency (251 ng).
Theoretically, maybe. Practically, I don’t know. There may be different routes of administration, potency issues, and more side effects if you give the active metabolite directly, so I don’t know 🤷♂️
Sir my son age is 3.10 years old and having normal B12 and Folic acid levels but homocysteine high 17.8( normal less than 15) Please help 🙏 Is this because of anti folate antibodies, or functional folate deficiency. Please suggest remidies.
@@MedicosisPerfectionalis USA passed laws to add B9 to all flour products but not other b vitamins causing more problems... ua-cam.com/video/OvMxJ6GRBNQ/v-deo.html
💊 Antibiotics Course: www.medicosisperfectionalis.com/
This is my first time being entertained while learning biochemistry
Wow 🤩
Thank you 😊
This dude is underrated
Thank you 😊
5:34 Conjugase enzyme
9:54 Benefits of Vitamin B9
13:40 Follate deficiency
pregnant woman, been taking Folate for a long time, due to recommendation online. Thank you for actually explaining WHY I needed it.
That was the best Jordan Peterson impression I've ever heard lmao!
I'm amazed by the way you teach
You have responded to all the questionsI have about this lecture thank you so much for this amazing creative concept
My pleasure 😇
I bow to the huge knowledge, but after 15 minutes of explanation I had to put my head into the freezer ;) thanks and best regards!
Haha 😂
I am not that knowledgeable!
I appreciate you so much!
I thank you very much for your great effort to simplify these scientific info to us. You are the great deal to me
Thank you so much 😊
😍 thank youu .. we missed you doctor
Thank you so much 😊
I can’t imagine learning ever being this fun. 😂 “fu, no fu”
:)
Seriously. You get me every time 🤣. “Fool me once... Fool me twice...” lol Thank you for your videos. They are so well made, clear, and concise.
Thank you so much, Rebecca!
I appreciate you!
i love the way u teach, thank u so much for this content 😭💜
Thank you so much!
Great job bro
Thank you 🙏
Came to drop my like💗
Thank you so much 😊
Criminally under-subscribed! I will spread the good word of Medicosis in Kyiv
Thank you so much 😊
Greatly insightful! Vielen dank!
Thank you sob
2:25 💀🤣 that is so accurate
Tq doctor very much
My pleasure 😇
Thank you sooo much ❤
You're welcome 😊
u r the best
Thank you 🙏
Thank you, I could not stop laughing hysterically. I have never been so entertained while learning. I'll keep coming back to your videos.
I appreciate you so much!
Would you please help me by sharing?
@@MedicosisPerfectionalisno
First comment from Egypt 💜💜💜💜
Thank you so much, dear 😊😊
I like your video,content
This makes me understand in really easy way
Thank you 🙏
Thanks again!
I think there may have been an error with conversion of Folic acid > DHF >THF. You mentioned they require Vitamin C. As far as I can find, the cofactor for these conversions is not vitamin C but NADPH. Vitamin C is mainly for certain hydroxylation reactions involving a metalloenzyme, like Dopamine > Norepinephrine. DHF to THF is just a reduction reaction, not a hydroxylation. The only relationship I can find between Vit C and Folate is that Vit C helps prevent oxidation of Folate/THF helping it stay reduced.
Excellent!!!
Thank you so much 😊
The way teach bro!!!!!! Killing it!!!
Thank you 😊
Thank you!
My pleasure 😇
Sir when will you start Endocrinology playlist???
And thankyou for your lectures!!!
It starts in December 2020.
그림이 너무 귀엽고 글씨도 좋아요
Great lecture 🎉lots of love from 🇦🇫🇦🇫
This is cool :) Thanks for the video.
My pleasure 😇
I'm by God's healthy 65yrsold and been dignoisnode in march with parkinson I. Recently been taking folate because of a article saying its a cure for parkinson iv noticed a decrease in my inflamationcan you tell me anything new on it please and thank you for this video
Awesome description doctor . Thank you so much. My mother has aplastic anemia from 2014. From few works ago, she got a muscular pain and also warming muscles.. What i need to know is, these symptoms are of hyperdynamic cirulatory?? I so that the anemia may cause to hyperdynamic circulatory.
Thank you
Any advice on what to take for thalassemia minor?
Can you do a video on MTHFR polymorphisms? Id like to know more about this subject because I have it.
That’s a good idea. Thank you so much!
How is your health today?
Sorry to intrude, but is that the one where you have problems processing sulfur?
@@Kimmy1412 it's ok you're not intruding. MTHFR is a problem with converting folate and folic acid to be used by the body do to a mutation. It can range from 20% to 80% reduction. In my case im homozygous with the mutation getting the gene from both my parents because of that im 75% reduced in my ability to absorb B9. I know the simple summary of it, but not the deeply technical parts of it.
@@MedicosisPerfectionalis im normally well, i usually have to take a supplement called L-Methylfolate. Before I was prescribed the medication, the doctors noticed my extremely high homocysteine levels and low blood count and told me that the supplement skips the part that is damaged. And ive always wondered about how the methlation process which you already talked about in this video, but what about foods you should or should not avoid, does it matter? And what happens to the unconverted B9 in my body? Does it hurt my kidneys or liver?
@MachineGunSally Thanks for reply. I think I'm confusing the MTHF with the CBS mutation. Thanks for clarifying & hope you find your answers.
Amazing way 🥰😍😍
Thank you 🙏
11:05 Me with a MTHFR polymorphism: "Well im screwed"
I am sorry 😐
Thanks ! That was helpful .
could you please provide me with a link to professor ames full record ?
Great video, as usual. Question. Is mesalamine also a folate antagonist? or. sulfasalazine is but mesalamine isn't? thank you.
Doctor genius 😂😂😂😂😂😂😂😂😂😂😂
Thanks medicosis❤😍, i woke up this morning and i got headache just by reading the folate cycle 😂😂😂 no need for folate deficiency 😅
Haha 😂
I am sorry 😭
Started watching out of curiosity about folate but stayed for comedy.😂
I am honored, Daniel!
Thank you so much 😊
Would you please help me by sharing?
I don't need to know this much, but how entertaining.
Thank you ☺️
Greaaaaaaaaat man
Thank you so much 😊
please activate english notifications on parameters
I am afraid I don’t understand.
Can you elaborate, please?
You make learning FUN lol
Hey Medicosis Perfectionalis, I know it's two years late... But I'm very interested in "fermentation residue factor". Do you know where that name might have come from? Thanks for the video!
Do you provide your notes?
Yes, on my website: www.medicosisperfectionalis.com/
Sir I'm confused with folic acid ..
Is folic acid vitamin B9 or vitamin B11???
Please answer.....
Some books have name vitamin B11 and some have B9 witch is correct one ...
Please answer...
B9
Nice
Thank you 🙏
7:48
is that pyrimidine synthesis .....>DNA-->RNA Synthesis? or
If you're a true EGYian the FIGLU test will remind you with some thing...🤣
Grat job you're the best 💚
Haha 😂
Thank you
Can you please complete the other vitamins
Vitamin C and fat soluble vitamins 🤍
I will
If there's b-12 deficiency, b-9 can't donate its methyl to b-12.
This way, which one should be treated first?
I feel b-12. But i need your answer.
Thanks for this wonderful video.
I have recently been diagnosed with B-9 deficiency (serum 0.44 ng) and B-12 insufficiency (251 ng).
could i take vitamin b9 before getting pregnant since its folate? can i take it during pregnancy
Hmmm... you're like the combination of Dr. Cox and JD from Scrubs. Great lecture btw
Haha 🤣
Wooww!!!!!! ✨✨✨✨
Thank you 😊
15:46 But red blood cells do not have a nucleus, do they?
They do not.
Omg, The Jordan Peterson dig! XD
Haha 😂
I need the pdf
On my website: www.medicosisperfectionalis.com/
Are 5-FU and 5-FC the same thing? One is indicated for cancer and one is indicated as an antifungal?
One is a metabolite of the other.
They are in the same pathway, much like azathioprine and 6-mercaptopurine.
@@MedicosisPerfectionalis Does this mean I could use 5-FU to treat fungal infections and vice versa?
Theoretically, maybe.
Practically, I don’t know. There may be different routes of administration, potency issues, and more side effects if you give the active metabolite directly, so I don’t know 🤷♂️
FAMM 😍😍😍😍FROM 🇵🇰
Thank you 😊
Please ,OCPs meaning???
Oral contraceptives 👌🏾
@@murtazahameed3833 thank you
Oral Contraceptive Pills 💊
@@MedicosisPerfectionalis thank you 🙂
hhahahha FU you make me laugh Mr MedicoPerfectionalist :D
Haha 😂
Laughter is a cheap medicine!
Thank you so much for watching!
Sir my son age is 3.10 years old and having normal B12 and Folic acid levels but homocysteine high 17.8( normal less than 15)
Please help 🙏
Is this because of anti folate antibodies, or functional folate deficiency.
Please suggest remidies.
Seed and nut contain it.
Came here for the folate, stayed for the lols
People with MTHFR care! Which is 40% of the population…
1:04 😂😂😂😂😂
There is problem when taking too much b9 with too little b12.
Folate will mask the hematological symptoms of B12 deficiency.
@@MedicosisPerfectionalis
USA passed laws to add B9 to all flour products but not other b vitamins causing more problems...
ua-cam.com/video/OvMxJ6GRBNQ/v-deo.html
❤️❤️
Thank you so much 😊
Ok… for once, someone taught me the true meaning of being conjugated
F U back" 😂🤣
💔muhh
🍌 🥬 Nutrition playlist: ua-cam.com/play/PLYcLrRDaR8_ejLKk85pAr8txLCVmNAVMq.html&si=o9goLcceJIcxDSBR
I've saved it
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🍌 Metabolism Playlist: ua-cam.com/play/PLYcLrRDaR8_f99ZucuCvQ6ecD3KzTVCi0.html
Why do I hate Biochemistry :((((?????
I don't know 🤷♂️
Try to understand its relevance and it will be way easier!
kiss my calcaneus loll 😂