Renue By Science NMN 10% discount: tinyurl.com/3wr8pr3t For Subscriptions, use code SUBMHS DoNotAge NM 10% discount code MODERNHEALTHSPAN tinyurl.com/5bh5s9an/ NOVOS Core & NOVOS Boost $5 with code MODERNnow5 novoslabs.com/?ref=3957 ProHealth 10% discount code MODERN : prohealth.pxf.io/c/3176409/1541296/17976 InsideTracker 20% discount: insidetracker.sjv.io/DVmqkn with code HEALTHSPAN20 Bulletproof 15% discount code HEALTHSPAN15 tinyurl.com/24hrxt72 If you would like to support our channel, we’d love a coffee ☕…thank you! www.buymeacoffee.com/mhealthspan Prof Micheal Zemel Playlist: tinyurl.com/4d7nw842
Whatever the studies show on NMN, I'm speaking from my own real-world experience. I've been taking 1 gram per day for over 9 months, and it's been a game-changer for me. The list of improvements is long and continues to grow on a regular basis. I can only imagine how things will be 9 months from now. Exciting! I take 1 gram of NMN, 2 grams of TMG, and intermittently 1 gram of apigenin. I've been on a carnivore diet for over 3 years and before that, low carb for about 2 years. I'm 64. I will be starting on leucine and resveratrol today. I have lost over 40 pounds in the past 4 years and since starting NMN I've lost an additional 12 with no change in diet.
@@ModernHealthspan you are most welcome. I do have a question that I would like clarification on, taking resveratrol at 100 grams lets say, because lucein will be inhibited by other amino acids, is that independent of its effects on resveratrol? So would resveratrol also be affected by taking a protein with amino acids? Or is this conversation just about lucien assisting resveratrol at different levels dependent on the amino acids surrounding lucein?
Just some show notes for people. 5:30 luceine must be 500 micromolar to do anything to stimulate fatty acid oxidation fat burning. It's a Sirt1 activater at the right concentrations. 8:30 Luceine taken by it's self in a fasted state actives Sirt1 without activating Mtor. It's hard to get enough Resveratrol into people. Add in Luceine to potentiate Resveratrol at lower doses. 14:02 Doses. Prediabetics 1 gram twice a day with 100mg Resveratrol reduction in insulin resistence, and reduction in insulin circulation and better response to oral glucose. 20:50 Luceine reduces the quanity of NMN needed to reach Sirt1 activation. Both NR and NMN have an affect on NAD.
Hey Jazen, 5:30 and again at 6:25 and again at 8:18 shows 0.5 Micromolar as measured in the plasma, not 500 Micromolar. Perhaps you caught the Host misquote 0.5 Millimolar at 9:11
This is fascinating. First of all, 100mg of resveratrol, while low with consideration to generating physiological effects, is still more than 100x as much as you would get from a single glass of red wine. Second of all, that the effects of leucine are attenuated with the addition of other amino acids means that to achieve this synergy it must not be taken with other food, as opposed to Sinclair taking his high dose resveratrol with fatty yogurt. Third of all, it's important to remember that leucine even in small amounts inhibits autophagy, so this strategy must be undertaken when not attempting to boost autophagy, ie not during a fast. Finally I thought nr and nam were found to be protective in the event of a stroke -although perhaps it's the inhibitory effects that are helping there, I don't quite remember. Absolutely finally, when in nature is there leucine and resveratrol but not isoleucine and valine? I wonder if this relationship is something that would ever occur in nature.
Thanks for sharing these points. I had not thought about the last point, but I would think the answer to the last one is "never". In nature leucine comes as part protein which would always have other amino acids with it.
Perhaps we could still have pure fats with the resveratrol. Proteins would be out though maybe a small amount in comparison to the leucine wouldn't have much of an effect, so something like a bit of heavy cream or creme fraiche to keep it closeish to the yogurt method. Carbs should also likely be avoided as they activate mtor.
@zer0nix Thanks for your Response. I have similar concerns. However, after all, it is just Theory or Speculation. Because although they achieved certain Results there may be more to this than just their supposed conjecture. As you know, Aminos work Mysteriously Together (Stnergy)😊 I recently began using 2 grams of Leucine per day with 1 gram of L-Carnitinen 1gram of Taurine & 5 grams of Creatine. The results to my organism is Incredible. I don't know if I'm getting younger, but my skin is much better & I have more Energy. But this is taken with other Supplements & Vitamins (Curcumin Olive Oil Walnuts etc) with an Organic Diet However, I would like to add Resveratrol to this combo, but not certain of the dosage. Thanks Again ...
Shouldnt you be able to absorb these molecules of reservatrol for it to work? Prompting your stomach with yoghurt to start digesting process is valid, and if not then why?
You asked all the right questions! Leucine needs to be on its own (not in whey). 1g Leucine, 250mg of 40% ginseng, 500mg NMN, 100mg of trans-resveratrol.
Great episode Richard. You did a great job drilling down on the details for us. Prof Zemel has so much knowledge that he might take for granted the simple stuff that your audience is interested in or needs clarification on.
I just read the paper from Prof Zemel from 2011 entitled "Effects of dairy consumption on SIRT1 and mitochondrial biogenesis in adipocytes and muscle cells". He says that dairy activates sirt1, contrary to soy. He also says that calcium activates sirt1. Whey has been shown to activate sirt1, perhaps the calcium it contains plays a role to achieve it, and that compensates for the fact that the leucine is mixed with other amino acids. I wonder if the video you made recently about whey's effect on reducing senescence in the heart works through SIRT1. This being said, I saw this study that says that a high protein diet, like those used for weight loss, may overactivate mTOR, which may lead to atherosclerosis: "High-protein diets increase cardiovascular risk by activating macrophage mTOR to suppress mitophagy". So relatively low dose whey is likely to be good for longevity, but too much maybe not.. Too much would also add to the methionine content.
One can easily get 1g + of leucine (per his study), BCAA, EEA, etc using whey, + resveratrol and I'd want to see a whey vs leucine alone + resveratrol study. There's also data suggesting whey improves glucose metabolism. He does mention that in the vid, not aware of direct comparative data however. It it true taking whole proteins can mitigate the effects an isolated AA.
Thank you Richard. Very informative, that said. My 2 cents observation. Dr Gabrielle Lyons stated that to get the Leucine type benefits, you need to consume 30 grams plus of quality proteins which creates a bolus blood spike. I had gotten various sources that said BCAAs were worthless, that said. Perhaps if these BCAAs were taken by themselves or with low dose protein, the blood bolus protein spikes may not have been happening. Seems to me that if one would eat a quality/quantity protein meal, say 45-60 grams worth, add a leucine supplement plus your NAD supplement, that may be a path to go. Getting seasoned myself(age63), might be worth taking Quercetin and Apigenin to reduce CD38 which could help with NAD levels. Quercetin and Apigenin have other benefits, at this point for me I will have to do follow up blood work in 6 months to see if they are real for me. The more I learn, the more ignorant I find I am. Of course for me I’m not chasing perfection, instead I’m going for excellence. I can always raise my bar.
Hi Niall thanks for sharing. I have also heard that for muscle building BCAA's separately do not add value, above and beyond having sufficient protein. The thing is I think there are two separate threads, one is that lower dose leucine on it own with NMN makes the NMN more effective, the other is protein requirements for muscle growth, that do require leucine but in combination with other amino acids and calories to activate mTOR.
I know he's said that high-protein meals don't raise blood leucine levels high enough for the SIRT1 effect. But what about essential amino acid supplements? Does the presence of other amino acids interfere with the effect? And on that note, is it necessary to take leucine on an empty stomach?
I'm an old school bodybuilder and one of our old hacks to get into a ketogenic state was to include leucine while fasting. I think this had to do with leucine causing a monophase release of insulin, ostensibly driving any circulating sugar into storage. This seems as though it would have the effect of driving up AMPk. It would seem, therefore, that leucine only works it's mTOR affects in the presence of other aminos/insulin. Please let me know if I'm barking up the wrong tree ( ;^D>
Hi Steve, thanks for sharing. Leucine is one of the main activators of mTOR and so it would certainly make sense to take it after a workout, though as Dr Zemel discussed, you may need other ingredients as well.
I just came back to Lipo NMN + Resveratrol so naturally keen to know what percentage of improvement. Robust improvement is nice to know but I was expecting something more clinical TBH
Glad you brought up liposomes. I went on this mix, myself because of the success I have seen with liposomal vitamin C. Why do so many researchers omit mention of liposomal formulas?
@@vladislavroytapel2830 My choice only comes from my good experience with liposomal vitamin C. I am not a biochemist. Do your own research. I got my NMN from Austin Nootropics.
Proline in the tau protein plays a protective role against tau aggregation, which is a key factor in neurodegenerative diseases like Alzheimer's. However, when proline is replaced by leucine (as seen in the P301L mutation), this protective effect is lost, and tau protein is more prone to aggregation
Why would we want to separate m-tor and sirtuine activation? Arent we interested in both loosing fat and stimulating anabolism. Am i missing something?
I've been using leucine with my NMN since I became aware of this but unfortunately for me, and others, leucine can cause digestive upsets. I need to figure out the circumstances where I can take leucine & at what dosage and support my NMN supplementation.
@@trevormallett750 I appreciate your suggestion. I see that . . . "HMB is a metabolite derived from the essential amino acid leucine. Some studies have suggested that HMB is an anabolic compound that increases muscle building after resistance exercise training and improves lean body mass. There are also claims that it decreases fat mass alongside the increase in muscle mass." so it makes sense for me to try that option.
I would like to see some studies using microcurrent therapy devices to achieve an electroporation effect to enhance the bioavailability of these supplements then taking leucine and resveratrol/NMN to see how much more we can turbo charge these supplements.
I recently fell and broke the stem between my pelvis and Greater Trochanter they decided to do a anterior replacement. Now I have had only positional pain hopefully get back to step racing 10 miles and sprints 9 min . Healthy 80 year old female athlete. Need to find out if osteopenia No arthritis. I have leucine do 2X/ day? Tan outside a lot 93 D3 level.
I wonder if glycine and (beta) alanine, both of which I take for building & maintaining muscle mass, have similar properties to leucine? For some reason, leucine wasn't even on my radar (in terms of using it as a gym supplement).
Hi Thanks for you question. Dr Zemel did not discuss glycine and alanine specifically but he did say that leucine was unique in its behaviour with SIRT1.
Hey! Would someone out there kindly translate for all us non-sciencey people who have ADHD brains and whose eyes glaze over when it comes to bio chemistry? I just want the Cliffs Notes version. What is the complete, proper protocol? Anyone? 😝 It would be greatly appreciated. 😊
"Dear Professor, thank you for your interesting presentation on longevity. However, I am a bit confused as I noticed that despite being 65 years old, you look much older. I have read that a healthy lifestyle can help slow down aging and improve appearance. Can you please explain how your concept of longevity relates to a healthy lifestyle?" This way, you express your skepticism without being rude or disrespectful. Instead, you give the professor an opportunity to explain his position and engage in a discussion.
IIf this is correct that means we can save money if we take less amounts of resveretrol and nmn compound with a gram of leucine I'm aware of the benefits of leucine but the one I'm taking includes isoleucine and valise I may have to change to pure leucine
Yep..But it means take all of them on the empty stomach.. so no fat necessary to get better absorption for NMN and resveratrol ? what if take 1200 first on the empty stomach and after take oil { olive oil} yogurt} with NMN and resveratrol ?
Fascinating interview Richard, again. One question I've been trying to learn about regarding the mtor conundrum is the relationship of insulin with Lucy and mtor. Considering the professor's discussion about plasma leucine levels I'm wondering where insulin levels fit in the equation. I listen to a podcast a couple of years ago about mtor and insulin on the HVMN podcast that discussed this and it suggested that insulin had a significant role combined with leucine and other factors.
@danielfinnhult7890 Am thinking that the olive oil would break your fasted state. unless your question was, what would be the result of introducing this mix *while already being in* a fasted state. Any discoveries since you posted this 3 months ago?
Has anybody quantified how much leucine can be taken orally by average as stand alone to still be considered to not activate mTor?. I see that some manufacturers produce a powder form but one flat spoon is equal to 5000mg of Leucine.
Hi! Is there a super high quality Leucine prof Zemel recommends taking? Have you started taking Leucine with your NMN and transresveratrol to amplify the effects and even save money? If yes, how is it going? Have you tested your NAD and bio markers to see if it has worked for you? What Leucine do you recommend there super good quality and a reputable company/brand?
Isn’t fat oxidation bad? Oxidative stress? I wonder how much leucine would be the human equivalent to reverse atherosclerosis in humans with an NAD booster!
Hi thanks for the question. Fat oxidation is the process of burning fat (as opposed to glucose) and is a "good thing" if you want to reduce your fat %. Whether you burn glucose or fat, Reactive Oxygen Species will be generated but in healthy cells with healthy mitochondria they will be neutralized. That is a good question, and the Professor has not done that test yet. If we take the resveratrol number as a gage it would be 1 or 2 grams.
Hi Scott, thanks for your comment. As I recall that was for NAD precursors. I thought he was very clear what he had as clinical data and what he had seen in pre-clinical models. He was sharing the results of his studies, what you do with that information is up to you.
Hi thanks for your question. So I am guessing a bit here but, the reduction was in atherosclerotic plaque, which builds up in the arteries and causes heart disease. The mice were LDL receptor mice, which have the LDL-C knocked out and so can be used as a model for metabolic disease in humans. So a potential positive effect on metabolic syndrome.
Hi thanks for the question. He has only done clinical trials with resveratrol and there the dose was 1.1 g twice per day. I don't think he specified the mouse dose, though he said they published a paper so you may be able to find it.
Disappointing (very) that Leucine from Whey protein powder (with accompanying other Amino Acids) won't get the job done as far as the "activation" in concert with NMN & Resveratrol. I take all three. Not looking to add something else (Leucine) to my already copious supplement stack. I did recently did add Carnosine to it based on information from a recent Greg Fahy video.
That is true because he could well be biased to his own company. One can never trust the proprietor only word without third party testing or others like Dr Brad Stanfield etc getting on board (doing their testing and evaluating papers). It makes sense because we are all here because we don't invest our health or trust Big Pharma cos they are only stimulating the surface I helping the masses whilst ensuring we are beholden and need them yet never getting betting but they certainly getting richer. Now I'm sure many that have more money than sense have started buying from his company because they can and won't hurt their pocket or health and won't know if doing any good getting their money's worth either. I'm going to see what others like Stanfield, Huberman etc have to say on Lucien paired with other aminos like NMN and resverstrol. Also to note, resverstrol paired with NMN does more harm than good yet these popular companies like DoNotAge, Renue By Science etc are still selling it as if beneficial and it's not (those two ingredients are detrimental together) see Brad Stanfield's video backed with science data broken down etc and not just by him. So, I too get a little concerned when the author looks old yet pushes something that could help him and yet he looks like he doesn't take it when he certainly looks like he needs to! It's interesting but need to do more research than just accepting this video. We need to be careful when we listen to these academics that we don't take their word as gospel like we've done in the past with doctors. We must take what they say and do one's own reconnaissance on the matter when it comes to our health. Because some are relying on our ignorance to just want to believe and ching ching in their pockets and more fool for us. I take some of these products but have done my research and will be with Lucein!😮
Yes Lutein and Leucine are very different, Leucine is an amino acid (used in utilization of protein), Lutein is carotenoid. They can be easily searched on Wikipedia for more details.
When the author looks old and looks like they need to take what they have researched and selling. Mmm need to one's own reconnaissance than just take this video's word. Need to see what Stanfield and Huberman etc have to say on the matter and I'm sure they will or soon will have their take on the matter. 😮
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Whatever the studies show on NMN, I'm speaking from my own real-world experience.
I've been taking 1 gram per day for over 9 months, and it's been a game-changer for me.
The list of improvements is long and continues to grow on a regular basis.
I can only imagine how things will be 9 months from now.
Exciting!
I take 1 gram of NMN, 2 grams of TMG, and intermittently 1 gram of apigenin. I've been on a carnivore diet for over 3 years and before that, low carb for about 2 years. I'm 64.
I will be starting on leucine and resveratrol today. I have lost over 40 pounds in the past 4 years and since starting NMN I've lost an additional 12 with no change in diet.
GREAT!!!! Tell me please where do get grass feed meat? and where do you buy apigenin. ?
I dont know how you do it, but you always have the most interesting videos in this space. Keep going!
Hi Bran, thank you for your kind comments!
@@ModernHealthspan you are most welcome. I do have a question that I would like clarification on, taking resveratrol at 100 grams lets say, because lucein will be inhibited by other amino acids, is that independent of its effects on resveratrol? So would resveratrol also be affected by taking a protein with amino acids? Or is this conversation just about lucien assisting resveratrol at different levels dependent on the amino acids surrounding lucein?
21:45
Just some show notes for people. 5:30 luceine must be 500 micromolar to do anything to stimulate fatty acid oxidation fat burning. It's a Sirt1 activater at the right concentrations. 8:30 Luceine taken by it's self in a fasted state actives Sirt1 without activating Mtor. It's hard to get enough Resveratrol into people. Add in Luceine to potentiate Resveratrol at lower doses. 14:02 Doses. Prediabetics 1 gram twice a day with 100mg Resveratrol reduction in insulin resistence, and reduction in insulin circulation and better response to oral glucose. 20:50 Luceine reduces the quanity of NMN needed to reach Sirt1 activation. Both NR and NMN have an affect on NAD.
Hey Jazen, 5:30 and again at 6:25 and again at 8:18 shows 0.5 Micromolar as measured in the plasma, not 500 Micromolar. Perhaps you caught the Host misquote 0.5 Millimolar at 9:11
This is fascinating.
First of all, 100mg of resveratrol, while low with consideration to generating physiological effects, is still more than 100x as much as you would get from a single glass of red wine.
Second of all, that the effects of leucine are attenuated with the addition of other amino acids means that to achieve this synergy it must not be taken with other food, as opposed to Sinclair taking his high dose resveratrol with fatty yogurt.
Third of all, it's important to remember that leucine even in small amounts inhibits autophagy, so this strategy must be undertaken when not attempting to boost autophagy, ie not during a fast.
Finally I thought nr and nam were found to be protective in the event of a stroke -although perhaps it's the inhibitory effects that are helping there, I don't quite remember.
Absolutely finally, when in nature is there leucine and resveratrol but not isoleucine and valine? I wonder if this relationship is something that would ever occur in nature.
Thanks for sharing these points. I had not thought about the last point, but I would think the answer to the last one is "never". In nature leucine comes as part protein which would always have other amino acids with it.
Why not to boost autophagy during a fast?
Perhaps we could still have pure fats with the resveratrol. Proteins would be out though maybe a small amount in comparison to the leucine wouldn't have much of an effect, so something like a bit of heavy cream or creme fraiche to keep it closeish to the yogurt method. Carbs should also likely be avoided as they activate mtor.
@zer0nix Thanks for your Response. I have similar concerns. However, after all, it is just Theory or Speculation. Because although they achieved certain Results there may be more to this than just their supposed conjecture. As you know, Aminos work Mysteriously Together (Stnergy)😊
I recently began using 2 grams of Leucine per day with 1 gram of L-Carnitinen 1gram of Taurine & 5 grams of Creatine. The results to my organism is Incredible.
I don't know if I'm getting younger, but my skin is much better & I have more Energy.
But this is taken with other Supplements & Vitamins (Curcumin Olive Oil Walnuts etc) with an Organic Diet
However, I would like to add Resveratrol to this combo, but not certain of the dosage.
Thanks Again ...
Shouldnt you be able to absorb these molecules of reservatrol for it to work? Prompting your stomach with yoghurt to start digesting process is valid, and if not then why?
You asked all the right questions! Leucine needs to be on its own (not in whey). 1g Leucine, 250mg of 40% ginseng, 500mg NMN, 100mg of trans-resveratrol.
What does nmn abreviation stand for
@@OleDiaBole Nicotinamide mononucleotide
Hey Doc Zemel. Get Busy and figure this out! We don't have forever.
Thanks for an excellent and very responsible podcast.
An important question is when to take the combination leucine with NMN or revesratrol? maybe in a fasting state?
Hi J, thanks that is a good question. I would need to check in the paper to see what they did but we did not get into it in the interview.
Great episode Richard. You did a great job drilling down on the details for us. Prof Zemel has so much knowledge that he might take for granted the simple stuff that your audience is interested in or needs clarification on.
Hi Armando, thanks for your kind comment. And something I need to keep working on for future interviews.
I am not surprised by the effect of Leucine because I use it on my muscles every day and I can feel it revitalizing!!!
Hi Napcsi, thanks for sharing. Great to hear that it works for you.
Dear Sir ...
How to take leucine and what dose
Minute 18 is very edifying for me. Thank you so much!!
I just read the paper from Prof Zemel from 2011 entitled "Effects of dairy consumption on SIRT1 and mitochondrial biogenesis in adipocytes and muscle cells". He says that dairy activates sirt1, contrary to soy. He also says that calcium activates sirt1. Whey has been shown to activate sirt1, perhaps the calcium it contains plays a role to achieve it, and that compensates for the fact that the leucine is mixed with other amino acids.
I wonder if the video you made recently about whey's effect on reducing senescence in the heart works through SIRT1.
This being said, I saw this study that says that a high protein diet, like those used for weight loss, may overactivate mTOR, which may lead to atherosclerosis:
"High-protein diets increase cardiovascular risk by activating macrophage mTOR to suppress mitophagy".
So relatively low dose whey is likely to be good for longevity, but too much maybe not.. Too much would also add to the methionine content.
The Calcium might be part of the Ca-Akg question as well. Thanks for bringing this up.
Richard please download the complete interview as one whole episode when you create the podcasts if possible
Another fascinating interview series, Prof Zemel is so knowledgeable, so much to learn from this episode, thank you you both!
Hey Ray, thanks for your comments and I hope that you find the series helpful.
David Sinclair said amino acids such as Leucine activate mTOR, which you don't want.
yes leucine is a very strong activator of mtor however 1 gram may not be enough to do this
One can easily get 1g + of leucine (per his study), BCAA, EEA, etc using whey, + resveratrol and I'd want to see a whey vs leucine alone + resveratrol study. There's also data suggesting whey improves glucose metabolism. He does mention that in the vid, not aware of direct comparative data however. It it true taking whole proteins can mitigate the effects an isolated AA.
Thank you Richard.
Very informative, that said.
My 2 cents observation.
Dr Gabrielle Lyons stated that to get the Leucine type benefits, you need to consume 30 grams plus of quality proteins which creates a bolus blood spike.
I had gotten various sources that said BCAAs were worthless, that said.
Perhaps if these BCAAs were taken by themselves or with low dose protein, the blood bolus protein spikes may not have been happening.
Seems to me that if one would eat a quality/quantity protein meal, say 45-60 grams worth, add a leucine supplement plus your NAD supplement, that may be a path to go.
Getting seasoned myself(age63), might be worth taking Quercetin and Apigenin to reduce CD38 which could help with NAD levels.
Quercetin and Apigenin have other benefits, at this point for me I will have to do follow up blood work in 6 months to see if they are real for me.
The more I learn, the more ignorant I find I am.
Of course for me I’m not chasing perfection, instead I’m going for excellence.
I can always raise my bar.
Hi Niall thanks for sharing. I have also heard that for muscle building BCAA's separately do not add value, above and beyond having sufficient protein. The thing is I think there are two separate threads, one is that lower dose leucine on it own with NMN makes the NMN more effective, the other is protein requirements for muscle growth, that do require leucine but in combination with other amino acids and calories to activate mTOR.
Gee, that was a fascinating interview!
Much thanks Prof. Zemel.
I know he's said that high-protein meals don't raise blood leucine levels high enough for the SIRT1 effect. But what about essential amino acid supplements? Does the presence of other amino acids interfere with the effect? And on that note, is it necessary to take leucine on an empty stomach?
I'm an old school bodybuilder and one of our old hacks to get into a ketogenic state was to include leucine while fasting. I think this had to do with leucine causing a monophase release of insulin, ostensibly driving any circulating sugar into storage. This seems as though it would have the effect of driving up AMPk. It would seem, therefore, that leucine only works it's mTOR affects in the presence of other aminos/insulin. Please let me know if I'm barking up the wrong tree ( ;^D>
Very interesting and informative video. I read that it is recommended to take leucine after a workout to improve the benefits of mTOR.
Hi Steve, thanks for sharing. Leucine is one of the main activators of mTOR and so it would certainly make sense to take it after a workout, though as Dr Zemel discussed, you may need other ingredients as well.
I just came back to Lipo NMN + Resveratrol so naturally keen to know what percentage of improvement. Robust improvement is nice to know but I was expecting something more clinical TBH
Glad you brought up liposomes. I went on this mix, myself because of the success I have seen with liposomal vitamin C. Why do so many researchers omit mention of liposomal formulas?
Do you believe that works better? Where do you buy it?
@@vladislavroytapel2830 My choice only comes from my good experience with liposomal vitamin C. I am not a biochemist. Do your own research. I got my NMN from Austin Nootropics.
Wow- what an interesting discussion. Thank you gentlemen.
Did anyone figure out exactly how much he recommended taking, when, how often and under what kind of fasted condition???
When would this pathway be activated in the wild? Like when would so much leucine be available without the other amino-acids also there?
Proline in the tau protein plays a protective role against tau aggregation, which is a key factor in neurodegenerative diseases like Alzheimer's. However, when proline is replaced by leucine (as seen in the P301L mutation), this protective effect is lost, and tau protein is more prone to aggregation
Hi thanks for sharing.
Why would we want to separate m-tor and sirtuine activation?
Arent we interested in both loosing fat and stimulating anabolism. Am i missing something?
Very interesting channel great video thanks!
Please link to the other episodes. Digging through your vids to watch the next one is too much work
I've been using leucine with my NMN since I became aware of this but unfortunately for me, and others, leucine can cause digestive upsets. I need to figure out the circumstances where I can take leucine & at what dosage and support my NMN supplementation.
Hi Thanks for sharing.
I wonder if you swapped leucine for hmb?
@@trevormallett750 I appreciate your suggestion. I see that . . . "HMB is a metabolite derived from the essential amino acid leucine. Some studies have suggested that HMB is an anabolic compound that increases muscle building after resistance exercise training and improves lean body mass. There are also claims that it decreases fat mass alongside the increase in muscle mass." so it makes sense for me to try that option.
I would like to see some studies using microcurrent therapy devices to achieve an electroporation effect to enhance the bioavailability of these supplements then taking leucine and resveratrol/NMN to see how much more we can turbo charge these supplements.
Thanks Richard.
Hi Ron, good to see you, thanks!
I recently fell and broke the stem between my pelvis and Greater Trochanter they decided to do a anterior replacement. Now I have had only positional pain hopefully get back to step racing 10 miles and sprints 9 min . Healthy 80 year old female athlete. Need to find out if osteopenia No arthritis. I have leucine do 2X/ day? Tan outside a lot 93 D3 level.
I wonder if glycine and (beta) alanine, both of which I take for building & maintaining muscle mass, have similar properties to leucine? For some reason, leucine wasn't even on my radar (in terms of using it as a gym supplement).
Hi Thanks for you question. Dr Zemel did not discuss glycine and alanine specifically but he did say that leucine was unique in its behaviour with SIRT1.
Prof. Zermel says in the interview that similar branched amino acids don't have the same effect.
Most supplements are for the isomer L-Leucine and not for the amino acid Leucine. Do you expect the two forms to have the same action?
Good job, Richard!
Hi David, thanks!
Hey! Would someone out there kindly translate for all us non-sciencey people who have ADHD brains and whose eyes glaze over when it comes to bio chemistry?
I just want the Cliffs Notes version. What is the complete, proper protocol?
Anyone? 😝
It would be greatly appreciated. 😊
1G of leucene + resveratrol , nmn, and other anti aging supplements. Leucene is supposed to supercharge them
Awesome video
Sounds like it is useful only for those who are pre diabetic
That is probably 50%, at least, of US adult population.
"Dear Professor, thank you for your interesting presentation on longevity. However, I am a bit confused as I noticed that despite being 65 years old, you look much older. I have read that a healthy lifestyle can help slow down aging and improve appearance. Can you please explain how your concept of longevity relates to a healthy lifestyle?"
This way, you express your skepticism without being rude or disrespectful. Instead, you give the professor an opportunity to explain his position and engage in a discussion.
Actually he looks like a A Jewish hasid and could be anywhere from 35 to 85..
Also this is frankly a foolish comment . Just because you study anti aging does not mean you have to look like Apollo.
@@joecarducci9627 it's not only about studying. It's about selling!
IIf this is correct that means we can save money if we take less amounts of resveretrol and nmn compound with a gram of leucine I'm aware of the benefits of leucine but the one I'm taking includes isoleucine and valise I may have to change to pure leucine
What's a good dose of lucine?
Lovely combination!
This is exciting news 😊
Yep..But it means take all of them on the empty stomach.. so no fat necessary to get better absorption for NMN and resveratrol ? what if take 1200 first on the empty stomach and after take oil { olive oil} yogurt} with NMN and resveratrol ?
Will Pterostibene and Leucine have the same afect ?
Fascinating interview Richard, again. One question I've been trying to learn about regarding the mtor conundrum is the relationship of insulin with Lucy and mtor. Considering the professor's discussion about plasma leucine levels I'm wondering where insulin levels fit in the equation. I listen to a podcast a couple of years ago about mtor and insulin on the HVMN podcast that discussed this and it suggested that insulin had a significant role combined with leucine and other factors.
I will feel somewhat more convinced if the guest speaking about longevity doesn't look at old as Santa Claus 😅
Yeah true, but maybe he was already very old when he discovered the effect of Leucine+NMN+resveratrol. And he didn't pretend it reverses aging.
He spoke about healthspan ....
Maybe he's 150 years old ?
I was thinking the same thing hope he is 110 years old
So pop a few caps of lucine with my NMN first thing in the morning and dont eat till noon
Would 1g L-Leucine, 1g NMN and 0,5g of Quercitin slurried in some olive oil) make a good mix at fasting conditions in the morning? Doses okay?
@danielfinnhult7890 Am thinking that the olive oil would break your fasted state. unless your question was, what would be the result of introducing this mix *while already being in* a fasted state. Any discoveries since you posted this 3 months ago?
Can i add to that mix NAC/Glycine/ taurine/A.L A
Very interesting.
What is the best brand of pure leucine? Anyone?
Thanks
Has anybody quantified how much leucine can be taken orally by average as stand alone to still be considered to not activate mTor?. I see that some manufacturers produce a powder form but one flat spoon is equal to 5000mg of Leucine.
Wait until you discover Di-Leucine.
Hi thanks for sharing. That looks really interesting. I had not heard of di-leucine before.
Yeah, this is all very interesting, but people are busy and this is nearly 50 minutes of techno-babble that calls out for 5-minute summary.
It's actually 20 min 😂
Isn't the French paradox centered around wine & cheese?
Checked me local vendors in this country and nobody appears to be selling leucine. Yay
What about HMB?
Good job dragging cogency from that professor
Hi! Is there a super high quality Leucine prof Zemel recommends taking? Have you started taking Leucine with your NMN and transresveratrol to amplify the effects and even save money? If yes, how is it going? Have you tested your NAD and bio markers to see if it has worked for you? What Leucine do you recommend there super good quality and a reputable company/brand?
Isn’t fat oxidation bad? Oxidative stress?
I wonder how much leucine would be the human equivalent to reverse atherosclerosis in humans with an NAD booster!
Hi thanks for the question. Fat oxidation is the process of burning fat (as opposed to glucose) and is a "good thing" if you want to reduce your fat %. Whether you burn glucose or fat, Reactive Oxygen Species will be generated but in healthy cells with healthy mitochondria they will be neutralized.
That is a good question, and the Professor has not done that test yet. If we take the resveratrol number as a gage it would be 1 or 2 grams.
Reversal of plaque? Zero clinical data. You better start generating some data!
Gonna need to listen to this one again. It was difficult to exactly understand what he was suggesting.
@@ScottSummerill He was hard to understand .
Hi Scott, thanks for your comment. As I recall that was for NAD precursors. I thought he was very clear what he had as clinical data and what he had seen in pre-clinical models. He was sharing the results of his studies, what you do with that information is up to you.
Reversal of plaque? You need to simplify that. That was caused by ????
Hi thanks for your question. So I am guessing a bit here but, the reduction was in atherosclerotic plaque, which builds up in the arteries and causes heart disease. The mice were LDL receptor mice, which have the LDL-C knocked out and so can be used as a model for metabolic disease in humans. So a potential positive effect on metabolic syndrome.
I'm a bit confused on what the recommended dosage is for humans. Didn't he say they gave 1 gram x2/day for mice?
Hi thanks for the question. He has only done clinical trials with resveratrol and there the dose was 1.1 g twice per day. I don't think he specified the mouse dose, though he said they published a paper so you may be able to find it.
Disappointing (very) that Leucine from Whey protein powder (with accompanying other Amino Acids) won't get the job done as far as the "activation" in concert with NMN & Resveratrol. I take all three. Not looking to add something else (Leucine) to my already copious supplement stack. I did recently did add Carnosine to it based on information from a recent Greg Fahy video.
Be skeptical of taking nutritional advice from anyone that doesn't look fit & healthy.
That is true because he could well be biased to his own company. One can never trust the proprietor only word without third party testing or others like Dr Brad Stanfield etc getting on board (doing their testing and evaluating papers). It makes sense because we are all here because we don't invest our health or trust Big Pharma cos they are only stimulating the surface I helping the masses whilst ensuring we are beholden and need them yet never getting betting but they certainly getting richer. Now I'm sure many that have more money than sense have started buying from his company because they can and won't hurt their pocket or health and won't know if doing any good getting their money's worth either. I'm going to see what others like Stanfield, Huberman etc have to say on Lucien paired with other aminos like NMN and resverstrol. Also to note, resverstrol paired with NMN does more harm than good yet these popular companies like DoNotAge, Renue By Science etc are still selling it as if beneficial and it's not (those two ingredients are detrimental together) see Brad Stanfield's video backed with science data broken down etc and not just by him. So, I too get a little concerned when the author looks old yet pushes something that could help him and yet he looks like he doesn't take it when he certainly looks like he needs to! It's interesting but need to do more research than just accepting this video. We need to be careful when we listen to these academics that we don't take their word as gospel like we've done in the past with doctors. We must take what they say and do one's own reconnaissance on the matter when it comes to our health. Because some are relying on our ignorance to just want to believe and ching ching in their pockets and more fool for us. I take some of these products but have done my research and will be with Lucein!😮
Physician heal thyself!
Is he trying to emulate Aubrey de greys beard lol
Is there a difference between lutein (which is in the Preservision supplement I take) and leucine?
Yes Lutein and Leucine are very different, Leucine is an amino acid (used in utilization of protein), Lutein is carotenoid. They can be easily searched on Wikipedia for more details.
When the author looks old and looks like they need to take what they have researched and selling. Mmm need to one's own reconnaissance than just take this video's word. Need to see what Stanfield and Huberman etc have to say on the matter and I'm sure they will or soon will have their take on the matter. 😮
aktienrente wäre top, damit endlich diese schrott riester rürup müll und schrott lebensversicherungen weg sind