Should you even use tretinoin? A scientific breakdown

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  • Опубліковано 17 чер 2024
  • Drug retinoids are some of the most powerful ingredients in skincare. So why would anyone use cosmetic retinoids? And are compounded drug retinoids the perfect middle ground between them? (No.)
    I break down drug, cosmetic, and compounded drug retinoids, which one you should use, and bust a whole bunch of retinoid myths along the way.
    Subscribe for videos every fortnight: bit.ly/labmuffinyt
    0:00 What are retinoids?
    1:53 Benefits of drugs
    8:23 Benefits of cosmetics
    12:24 Which one should you go for?
    14:14 Compounded drug retinoids
    Does retinol in skincare even work? • Does retinol in skinca...
    Blog post with more info and full references here: labmuffin.com/drug-cosmetic-c...
    Powered By Chemicals Mugs: labmuffin.com/shop/
    🙋🏻 I'm Michelle, a chemistry PhD, cosmetic chemist and science educator, here to explain how beauty products work, debunk myths, and help you make smarter decisions about your skincare, hair and makeup!
    Blog labmuffin.com
    Instagram / labmuffinbeautyscience
    Threads www.threads.net/@labmuffinbea...
    TikTok / labmuffinbeautyscience
    ✨ Want smooth, glowing skin? Grab a copy of my FREE Essential Guide to Exfoliation! labmuffin.com/exfol
    📺 RELATED POSTS AND VIDEOS
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    Blog post for this video with more info: labmuffin.com/drug-cosmetic-c...
    🧴 SKINCARE GUIDE 🧴 Find out more: labmuffin.com/skin
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КОМЕНТАРІ • 809

  • @justilou1
    @justilou1 5 місяців тому +1502

    I have been using 0.25% tretinoin since my early 20’s. Originally it was for PCOS-caused acne. It sorted out the lesions and clogging pretty damn quick and I stuck with it - AND sunscreen of course. I’m in my 50’s now and apart from my pregnancies, I have used it every day. My complexion is much firmer and clearer than most women my age and basically, they’re going to have to tear it from my cold, dead claws when I’m dead.

    • @jenA9026
      @jenA9026 5 місяців тому +38

      😂

    • @rics1883
      @rics1883 5 місяців тому +4

      Do you get compliments for your skin?

    • @sarakim1070
      @sarakim1070 5 місяців тому +30

      I love this comment so much 😂

    • @katieprice8076
      @katieprice8076 5 місяців тому +23

      🎉🎉 Do you mean .025 or .25?

    • @childoftheocean_
      @childoftheocean_ 5 місяців тому +2

      Did you notice a difference in wrinkles?

  • @seanvalentinus
    @seanvalentinus 5 місяців тому +1313

    Michelle: "Guys, *STOP* bullying hyaluronic acid 😡😡😡 they are a *good* little active ingredient and they're trying their best and I am *proud* of them 😡😡😡😡"

    • @LabMuffinBeautyScience
      @LabMuffinBeautyScience  5 місяців тому +407

      Justice for Hyaluronic Acid! 😡😡😡

    • @leannepllpplplpbenn363
      @leannepllpplplpbenn363 5 місяців тому +63

      On the subject of hyaluronic acid, it would be very useful to know if, in a dry climate, it takes moisture from your skin. Would you be able to advise on that?

    • @Monica_706undercvr
      @Monica_706undercvr 5 місяців тому +3

      😂😂

    • @sarahpaesfrare4776
      @sarahpaesfrare4776 5 місяців тому

      Please I have the same question aboit glycerin ​@@leannepllpplplpbenn363

    • @burtnation1357
      @burtnation1357 5 місяців тому +30

      My skin doesn’t like it

  • @shmachable
    @shmachable 5 місяців тому +146

    This has nothing to do with skincare, but your crochet top is just.... *chef's kiss*

  • @SamFerro
    @SamFerro 5 місяців тому +484

    Ma’am I’ve been SCOURING Reddit for this information - specifically around the compound formulas. This video is everything and more thank you SO much

    • @Nurse_Lucy
      @Nurse_Lucy 5 місяців тому +2

      Any good brands you've found since this video? I don't have my computer with me on my current contract so looking up the papers she mentioned is hard

    • @Giancarlo-wv3lv
      @Giancarlo-wv3lv 4 місяці тому

      Buena chama!

    • @SamFerro
      @SamFerro 3 місяці тому +2

      @@Nurse_Lucy sorry just saw this! I was just using dermaticas compound formula which I actually loved for the enhanced azelaic acid but I was curious if the tret was doing anything since (1 the treatments expired within like 2 months and (2 I was able to use quite a bit without dryness / flakiness (even tho my skin is super dry normally and esp dry with generic tret). I’ve since switched to generic tret and I feel like my skins making use of it better than it did w dermatica (tho that could definitely just be in my head).

    • @melissatranfield4054
      @melissatranfield4054 2 місяці тому

      @@SamFerro Hi, thank you for sharing this! I have started the Skin + Me compounded formula, and I feel like the added azelaic acid and niacinamide could be irritating my skin + making the tret less effective. I'm thinking to switch to pure tret, where did you get yours from? And what strength are you using? Thanks!

    • @tommyjohnson2279
      @tommyjohnson2279 16 днів тому

      ​@melissatranfield4054 I have nothing to do with this comment, but I found it interesting. I get mine from nurx it's about the same amount of money but straight from the pharmacy.

  • @emilyymarie90
    @emilyymarie90 5 місяців тому +502

    you are one of my favorite creators. translating this scientific information into easily understood content is no small feat and you seem to do it effortlessly.

    • @LabMuffinBeautyScience
      @LabMuffinBeautyScience  5 місяців тому +65

      Thank you! I've worked really hard at it 😊

    • @TheBaumcm
      @TheBaumcm 5 місяців тому +23

      @@LabMuffinBeautySciencethat is why I love watching your content as well. Having been in the field, Micro and Genetics background, I know full well that knowing content and delivering it in a digestible way, to those without the same background (people are often so specialized that going even a step outside of their field can feel like foreign language acquisition) while delivering a conclusion that appeals to common sense, rather than manipulation and fear mongering, is rarer than anyone realizes. Plus, the hilarious cutaways, I watch for the hilarious cutaways too!😂

    • @plaster.art.ho3
      @plaster.art.ho3 5 місяців тому +2

      Yesss. Nt a big nerd bt I love anything & everything skincare esp tret n ss so having all these digestible info is sooo helpful ❤

    • @plaster.art.ho3
      @plaster.art.ho3 5 місяців тому +2

      ​@@LabMuffinBeautySciencewe love u!!! 🥰🥰

  • @MatheusFerreira-mu6lu
    @MatheusFerreira-mu6lu 5 місяців тому +477

    I live in a place where 0.025% tret is over-the-counter and my skin is very tolerant to It... Using Tretinoin this past year has been great for the appearance and health of my skin. Never dealt with problems related to irritation... And my acne is 99% gone 😺

    • @SamMKKK
      @SamMKKK 5 місяців тому +89

      Ah, yes. How does it feel to be God’s favorite?

    • @noimnotakpoppfpsheacy2526
      @noimnotakpoppfpsheacy2526 5 місяців тому +23

      And which country is that?

    • @Bodoque-yt3px
      @Bodoque-yt3px 5 місяців тому

      @@noimnotakpoppfpsheacy2526most Latin American countries

    • @lauriannajones
      @lauriannajones 5 місяців тому

      Can it help dry skin?

    • @kathrynclark1585
      @kathrynclark1585 5 місяців тому +21

      Oh my gah I wish the US would allow that!

  • @seanvalentinus
    @seanvalentinus 5 місяців тому +220

    "It's a bit like hazing, but for molecules."
    Genuinely laughed out loud at that one. Love your work Michelle.

    • @sandragee2864
      @sandragee2864 5 місяців тому +3

      😂😂 I had the same response and posted the exact same comment as you! Since you beat me by 22 hours, I deleted my post and gave your comment a thumbs up.

    • @Portia620
      @Portia620 4 місяці тому +2

      I just found her and love her video with poor Kenny and the fire!🔥 😂🤣. Then the hazy statement! Creative! Love it

  • @mollycook1847
    @mollycook1847 5 місяців тому +106

    Crazy good video Michelle. I often "feel" like medical professionals and researchers aren't always on the same page, and this was an excellent explanation without going into "doctors don't know what they're talking about" territory.

  • @fatimahernandez302
    @fatimahernandez302 5 місяців тому +52

    i seriously can’t get over how amazingly informative and helpful your videos are. They are so thorough yet easy to understand.

  • @PinkieSugar
    @PinkieSugar 5 місяців тому +21

    really informative without being confusing! being able to simplify info like this without dumbing it down is the mark of a great teacher.

  • @jenxsj3902
    @jenxsj3902 5 місяців тому +126

    I started with tretinoin at the age of 16 due to acne. After 5 years I took a break but then returned to tretinoin until I was about 30 when I used oral isotretinoin for 10 months. After my acne was done I had read so much about retinoids that I chose to use them as anti aging. I tried different types of retinoids but went back to using prescription tretinoin five times a week, just a pea size and I moisturise to high heaven. You are absolutely right, the package is extremely important, I store them in the right temperature and follow the instructions on the package. I am 49 and I look like a porcelain doll. Of course SPS 50+ at least 2-3 daily.
    I am no doctor but i have been reading about retinoids for 30 years and I know you are giving the best and most relevant information. Michelle you are an SPF angel sent to us. Thank you.

    • @katkatkat5
      @katkatkat5 4 місяці тому +3

      I’ve been storing my prescription tretinoin in the fridge. Is that ok???

  • @murdermittensnyc
    @murdermittensnyc 5 місяців тому +20

    Brilliant mention of the “buffering” process around 12min. Super important distinction!

  • @listeningatwork8719
    @listeningatwork8719 5 місяців тому +207

    I switched from a compounded tretinoin from Curology to a generic prescription tretinoin cream. There definitely is a difference. My dark spots are fading quicker with the generic tretinoin cream, even without the added tranexamic acid and niacinamide that was contained in the compounded formula from Curology.

    • @ALT-vz3jn
      @ALT-vz3jn 5 місяців тому +17

      The Curology formula wrecked my face. Things are much better with just plain tretinoin from the pharmacy.

    • @chisoey2986
      @chisoey2986 5 місяців тому +6

      I use a similar service from Australia called Software. I used compounded 20% azelaic acid, and another formula with 0.0185% tretinoin. Both products contained niacinamide in a hyaluronic acid base. I’ve seen moved on to generic brands (OTC 20% AA and prescription 0.05% tret) and there’s a lot less redness, warming of the skin, and irritation. My tret is 0.05 now which is almost 3x the concentration of my compounding formula and there’s no irritation for me.

    • @alexmccullough2317
      @alexmccullough2317 5 місяців тому +3

      @@ALT-vz3jn same I thought I was the only one. Used it for about two months and I could not stop purging. Purging should only last a couple of weeks

    • @BlakeGober-mo6sq
      @BlakeGober-mo6sq 5 місяців тому +2

      Same. Curology wrecked my face. Gave me PIE and after just stopping 1 day my skin is MUCH better. Never again will I use curology.

    • @shannonm8512
      @shannonm8512 5 місяців тому +7

      I’ve had the same experience with Curology vs generic tretinoin, since switching to the generic tretinoin my skin is so much calmer and I’ve actually been able to increase the concentration of tret with no irritation. My skin was constantly irritated and sensitive while using curology.

  • @ketrakrelek2347
    @ketrakrelek2347 5 місяців тому +11

    hype! literally been on a lab muffin binge watch this week as a new sub

  • @WiseFamin
    @WiseFamin 5 місяців тому +8

    Your videos are always super helpful, and this one has to be one of the most helpful ones you've made. THANK YOU.

  • @halinameson2946
    @halinameson2946 5 місяців тому +3

    Another great video. Looking forward to the next two follow up videos. Especially the cosmetic retinoids. Always watch you !!

  • @cdn7120
    @cdn7120 5 місяців тому +9

    This was SO good!! The bioequivalence regulation explanation was fascinating 💡

  • @ana_samana
    @ana_samana 3 місяці тому

    this channel is a gem for dermatologists. thanks for scientific approach! i've subscribed.

  • @safa1012
    @safa1012 3 місяці тому +2

    This is my new favorite channel!!

  • @pull_up_the_roots
    @pull_up_the_roots 5 місяців тому +6

    Love your videos! I always learn a ton and come away from it feeling empowered to make better skin care choices!

  • @biochemlady
    @biochemlady 5 місяців тому +32

    I just finished my MSc in biochemistry and I have always loved all things makeup & skincare… your channel is a mix of my two favorite things to geek out about! 💕

    • @christine_notchristina
      @christine_notchristina 5 місяців тому

      I love your comment and your profile picture, so that means I adore you! Same here!

  • @ecested
    @ecested 2 місяці тому

    Wow. This is by far the most informative retinol video I have ever seen. Thank you!

  • @a-sf8hi
    @a-sf8hi 5 місяців тому +3

    Thank you Michelle for all the information, your hard work and time! 🧡🧡🧡

  • @ennsa3
    @ennsa3 3 місяці тому

    Thanks for the breakdown Michelle! Great video as always❤

  • @BriseisMusic
    @BriseisMusic 5 місяців тому +10

    That was really interesting about the custom formulas! I've been wanting to try them to reduce my skincare routine, but it makes sense that it might not be as effective

  • @lemontree1481
    @lemontree1481 5 місяців тому +3

    Really great, understandable video with a high scientific standard. Tank you so much ❤. We really need more of those type of vids wehen it comes to skincare.

  • @ThereAre4Lights
    @ThereAre4Lights 5 місяців тому +4

    Incredible video as always ❤

  • @apresmoa
    @apresmoa 5 місяців тому +6

    Thank you to yourself and all experts who helped. I'm going to try starting on Retinols this year and I have dry skin so I figure I need to go in easy! Meanwhile my Derm just rx me a prescription Trentinoin cream from a compounding pharmacy that's like $60 a month - so I'm glad I saw this video first!

  • @freethetomatoes
    @freethetomatoes 5 місяців тому +50

    You are such a blessing to this community! Thank you for your hard work! ❤

  • @umilele
    @umilele 5 місяців тому

    Your video quality has improved so much! 🎉❤

  • @leileleileleile
    @leileleileleile 5 місяців тому +2

    this was a great breakdown (and fascinating!)

  • @deepdabbler
    @deepdabbler 5 місяців тому +4

    I really appreciate the work that you put into producing this insightful video. I was on the verge of trying out a compounded retinoid.. now I will just stick to the OTC brand name retinols I currently use 🙂. You just saved me a bunch of money and aggravation!

  • @ChristaEvelyn
    @ChristaEvelyn 5 місяців тому +26

    This whole video is why I rely on experts like you 💜 also - sweater is SWEATERING 💜

    • @mrsbinkbonk
      @mrsbinkbonk 5 місяців тому +2

      It is isn’t it!❤

  • @sandragee2864
    @sandragee2864 5 місяців тому +2

    Michelle, I *love* your crocheted top! Such a vintage look. It reminds me of a similar top that my grand mom hand crocheted for me which I wore in the 1970’s.

  • @arianathough2070
    @arianathough2070 5 місяців тому +114

    You are amazing, tysm for the thoroughness and honesty here 🙏 I used tret for 4 years and it ended up leading to an outbreak of perioral dermatitis. Now my skin is so sensitive and reactive that almost any product can trigger the PD again (as well as other conditions now too) and it's SO hard to manage and treat, even with antibiotics. I wish people were better informed about the pros and cons of different actives, there's so much mystification in this industry.

    • @sheridanbeverley9173
      @sheridanbeverley9173 5 місяців тому +17

      I sympathise with you. I didn't use tret for as long as you but I tried it (0.05% once a week for 4 weeks) and I now have rosacea and the skin on my face is extremely sensitive. I regret it so much. My poor skin barrier 😔

    • @tortadepimenton
      @tortadepimenton 5 місяців тому

      @@sheridanbeverley9173I’m so sorry you went through that :( but yeah 0.05 is pretty strong as a starter

    • @tortadepimenton
      @tortadepimenton 5 місяців тому

      @@sheridanbeverley9173you are going through that***

    • @CrystalRose1111
      @CrystalRose1111 3 місяці тому +1

      @@sheridanbeverley9173Tretinoin obliterated and aged tf out of my skin, I even got a dry/raw patch that left a terrible scar. This all went away slowly once I stopped using it. If you live in a super dry climate and don’t have great water quality, please do not use tret. If you can’t provide the hydration that your skin needs, tret will make your lines and wrinkles WORSE.

    • @NarminSultanova-ds5yt
      @NarminSultanova-ds5yt 2 місяці тому

      Hi im sorry for you, did your skin healed?​@@sheridanbeverley9173

  • @Stitchin_is_the_Besst
    @Stitchin_is_the_Besst 4 місяці тому

    Omgosh!! SO much great information! Thank you!! ❤❤❤(And I LOVVVVVE your crocheted top! 🥰🥰🥰)

  • @keepitmoving1119
    @keepitmoving1119 5 місяців тому

    Thank you for you hard work on for sharing and explaining the information and your knowledge. I’m grateful for all your videos. Especially this one because we can see here and there everyone praising tret but almost nobody really discuss all the details and difference between the drug, the coumpounded drug and the cosmetic.

  • @knowledgehunter_
    @knowledgehunter_ 5 місяців тому

    I'm so glad that I am your follower from a long time. Thank you for your efforts!

  • @trefleacinqfeuilles7193
    @trefleacinqfeuilles7193 5 місяців тому +4

    how am I supposed to focus on the topic of video with this georgous crochet work fighting for my attention, it's just too good

  • @jenessastrickland1555
    @jenessastrickland1555 5 місяців тому

    Thank you so much for explaining all these things in depth!

  • @JillKnapp
    @JillKnapp 5 місяців тому +2

    Michelle posts, I stop whatever I'm doing and get to learnin'!

  • @saul.fernandes
    @saul.fernandes 5 місяців тому +1

    Amazing! So clear 😊

  • @tabithahamby4693
    @tabithahamby4693 5 місяців тому

    Pretty and smart and honest and funny helped redeem my skin. Thank you for all you do! ❤

  • @juliemoses1909
    @juliemoses1909 5 місяців тому

    Excellent video. Really informative. 👏🏻👏🏻👏🏻

  • @avigailomichael
    @avigailomichael 5 місяців тому +3

    Third!!! Love you, Michelle! You're irreplaceable.

  • @davidsotir4318
    @davidsotir4318 5 місяців тому +11

    Thank you SO much Michelle - this is the MOST useful video on choosing retinoids I've seen yet! I also live in Australia and previously used Stieva 0.025% tretinoin. Is it now discontinued? I used Retrieve 0.05% which was too strong. What other brands are available in Australia? (It's very difficult to find any definitive information online.)

  • @2009thera
    @2009thera 5 місяців тому

    This was so informative, thank you!

  • @findingwhimsy
    @findingwhimsy 5 місяців тому +61

    Well, this video gave some clarity for my experience with Tret for a year. I tried all the tricks recommended to ease in and prevent irritation. For months, my skin was just very inflamed, irritated and dry. My skin never got used to Tret. I felt like a wasted a whole year. I have carefully tried the Cerave retinol and so far so good. I do have East Asian skin and often have reactions to things I try in addition to that. Tret is just too harsh for me no matter what I try.

    • @roguecodes
      @roguecodes 5 місяців тому +19

      omg someone else!! Every time I’ve tried tret my skin flips out no matter how long I try it

    • @ZijnShayatanica
      @ZijnShayatanica 5 місяців тому +3

      That was me w/ Adapalene... I'm considering trying it again, since I started Testosterone & my skin is more oily/congested than it was before. But it's definitely a gamble.

    • @lelalu101
      @lelalu101 5 місяців тому +7

      ​@@ZijnShayatanicaI've failed at rx retinoids a bunch of times. Using the ordinary pink serum as part of my routine has kept me going on

  • @maddie8415
    @maddie8415 5 місяців тому +42

    I used Curology's "custom" formula for about 6 months and then switched to the regular tube of tretinion. My Curology formula had 0.035% tretinion, and the regular tube was only 0.025%. I have to say that my experience made me feel that the tretinoin on its own was more powerful despite being a lower percentage, because I was getting the initial purge and sensitivity all over again when I made the switch! This does explain it, thanks.
    Curology also presents a 25g container as a "2 month supply", when my doctor prescribes me a 20g tube of tretinoin as a one month supply...no wonder I always ran out of the Curology formula weeks before I was supposed to despite using the amount recommended! They do this on purpose, surely, because you can request your shipment early. More money for them.

    • @miss_jess
      @miss_jess 4 місяці тому +2

      what are you doing to use 20g in 1 month?! my prescription is a 25g tube and it lasts me almost a year

    • @maddie8415
      @maddie8415 3 місяці тому

      @@miss_jessTretinoin typically comes in either a 20g or 45g tube. I'm willing to bet that yours is 45g. If yours really is 25g I'd be wondering how on earth you could stretch that to a year. I can't imagine it being enough to be effective or applied evenly. I use a 20g one in about 6 weeks, but it's the amount I'm "allowed" to get per month. I have it in a low-ish percentage that I tolerate well and I put it on my neck as well as my face. Not a huge amount, but not the "pea sized" amount recommended for beginners.

  • @LNHRM
    @LNHRM 5 місяців тому

    This video opened my eyes. Thank you!

  • @onipot9639
    @onipot9639 5 місяців тому

    Excited for cosmetic video!! X

  • @MrLclm18choir
    @MrLclm18choir 5 місяців тому +2

    Love this channel. Thank you!

  • @jojoba11
    @jojoba11 5 місяців тому

    hahaha we did it, Joe! Thank you, excellent work, Michelle!

  • @leeshaolivier9298
    @leeshaolivier9298 5 місяців тому

    Duch helpful information!🥇

  • @sebumpostmortem
    @sebumpostmortem 5 місяців тому +17

    That explains perfectly why my Saint Derm (healed my acne with isotretinoine and supervised the long scar removal process) is so strict when it comes to the treti brand. It' s OTC in my country so he always insists: "IT MUST BE FERRER LABS. MUST MEANS MUST, I KNOW WHAT I' M TALKING ABOUT". I' m gonna share your vid with him so he can nod in peace for 17 mins😉. Thank you for your hard work. Happy Whateveryoucelebrate🧛🏻‍♀️🖤

  • @mimmy0193
    @mimmy0193 5 місяців тому

    Thank you so much for including compounded skincare,

  • @ttdur8102
    @ttdur8102 5 місяців тому +4

    I really love curology because they educated me and informed me to use sunscreen (I know, I know). I started using over the counter products used from the formula they gave me and my skin has already improved sooo much.! My texture and hyperpigmentation improved…. But I ditched them for Dermatica. Curology’s face wash they gave me seems to have the shards or crystals mentioned, and I wanted tret so I made the switch. When I feel comfortable I’ll change to just tret and not the formula. Nice video and thank you for the information 🤗

  • @kereti71
    @kereti71 5 місяців тому +7

    good lordie you're ACE. Thanks - I 've tried explaining the difference betwixt the OTC and prescription , to my friends and 9 times outta 10 - just give up. Hence forth this vid shall be my go to. Cheers

  • @buggydust
    @buggydust 5 місяців тому

    wonderful video! my coworker and i were just talking about wanting to figure out a good starting place for retinoids!

  • @reneetostengard7212
    @reneetostengard7212 3 місяці тому

    Unrelated to the video, but the color of your top looks so good on you!!

  • @4chao1999
    @4chao1999 5 місяців тому +72

    I have really sensitive skin, so it was hard to find an acne solution that worked for me. Tretinoin was surprisingly much more tolerable and effective for me than Duac and BHAs.

  • @janmcmahon7358
    @janmcmahon7358 5 місяців тому +8

    Thank you for this scientific deep dive. I use a prescription service (Agency}. I have used prescription tretinoin for years and constantly battled irritation. My formula has Tretinoin, Niacinimide, tranexamic acid and Panthenol. If there are formulas out there that are separate for the $30 a month I payI would love to hear about it. Also I got so tired of layering all these different products on every night and many times would quit before completing the seven steps needed. With the Agency I use a moisturizer and their formula and it simplifies things. Love your scientific take on everything

  • @mikay8962
    @mikay8962 5 місяців тому +3

    Thank you so much for the amazing work! I love your channel and all the information you share.
    I have acne and I tried out tretinoin for the first time in november. Before that, I had been using adapalene for the last 8 months and my skin was really better (I had an awful breakout at the beginning of the year).
    I followed the steps from your tutorial video.
    My skin started to breakout since the first application, I kept using it for 4 weeks, but it didn't got any better, only worse. So I stopped using it and I'm treating my acne with benzoyl peroxide.
    Wondering if I should go back to adapalene and just stick to it. I wanted to try tretinoin because of the evidence in anti-aging effectiveness, but after this breakout, I don't know if I should try again :/

  • @lindseycassini1560
    @lindseycassini1560 5 місяців тому +3

    Awesome video ❤ I always wondered if this custom formulas are actually tested for efficacy as a whole, or if they just assume it is, based in the tretinoin percentage.
    I am using now a custom one just because is easier for the adaptation period. I can use it every day with small percentage and increase it gradually, and I don't need to measure the ideal amount.
    But, my idea is to switch to prescription once I have reached a percentage that is available as a drug (I think minimum is 0.025).
    On this topic, I would love to see next a guide on how to choose the best retinoid prescription 😊 There are so many options and brands, not sure yet what is best for me.
    Thanks ❤

  • @Undefinedinc
    @Undefinedinc Місяць тому

    Sooo good. TY Michelle 🤍

  • @UnpurrfectRobyn
    @UnpurrfectRobyn 5 місяців тому +3

    I'm intrigued by the science behind skincare. I appreciate how you make it palatable and easier to understand! I've been using OTC Adaplane for over a year now with no pronounced irritation. I considered trying out a compound formula from Dermatica or Apostrophe since cosmetic derms are sparse in my area, but now I'm reconsidering. Adapalene has been working for me and I have enjoyed the results, though my acne isn't completely gone. Maybe I should just stick to Adapalene while I search for a cosmetic dermatologist who can advise if trying a stronger, prescription-strength Adaplene or a low percentage of Tret would be the best next step for me.
    Thank you for sharing your knowledge and hard work with us!

    • @Alex-dj9qj
      @Alex-dj9qj 5 місяців тому +2

      I'd say stick to what works, I was on tret before and it wrecked my skin. Adapalene gave me glowy and smooth skin after, something that tret never could. Plus no irritation 🤷🏻‍♀️ I don't want to discourage you but if something works for you, stick with it long-term unless it's damaging your skin in some way obviously. You can try and trial some tretinoin to see for a few months maybe

  • @Trinh_lucia
    @Trinh_lucia Місяць тому

    Following you in all platforms

  • @msmakeupjunkie96
    @msmakeupjunkie96 5 місяців тому

    Love your top!

  • @BlahBlahPoop617
    @BlahBlahPoop617 5 місяців тому +4

    Lab muffin is the best.

  • @amarug
    @amarug 5 місяців тому +61

    I am Scandinavian and very pale. I always thought I had a bit sensitive skin but when I started with retinol and then switched to adapalene a few months later, I never felt any irritation, nor got any redness. I didn't really read much about "and I more or less slapped it on like moisturizer" (avoiding eyes) and then added another layer of moisturizer cocktails from hadalabo and cerva (two of my favourite brands) and at the end sealed it all in with a good layer of vaseline to make it penetrate deeply and went to bed. Still no irritation ever and my skin became 10 years younger within a year. I have now dialed down on the adapalene, mainly because it seems a bit of a waste to use that much, but honestly never had as much as an itch or a red spot.

    • @Alex-dj9qj
      @Alex-dj9qj 5 місяців тому +11

      Adapalene is so good! My skin reacted badly to tretinoin then I tried Differin (I had acne so I needed something). Differin changed the game! 3 months later, not much acne anymore, no irritation or redness and glowy skin!! I once couldn't believe my skin texture after I had washed it and hadn't applied my moisturiser yet. I looked at it and it seemed to have a "shiny" film and I was so weirded out because I thought I hadn't washed my face well. It turned out that was the texture of my skin LOL, very smooth and glowy even without products on. It's wild. I don't ever plan on giving up Differin especially since it's easily available here in the UK through a pharmacist.

    • @Lexmorningstarnz
      @Lexmorningstarnz 5 місяців тому +2

      I get zero irritation from tretinoin either, but I did with over the counter retinol. So odd haha

    • @myown2101
      @myown2101 3 місяці тому

      I started with tretinoin, but had too much irritation. Used adapalene for about two years with no irritation. Simple skincare routine. Switched to tretinoin about two months ago with zero irritation too minimal irritation and purging. The greatest part about adapalene - you can pick it up at any drug store.

    • @LivMeadowvalley
      @LivMeadowvalley 3 місяці тому +1

      @@Alex-dj9qjwhat brand do you use?

    • @English.Nazmeen
      @English.Nazmeen Місяць тому

      I think we only have Differin brand adapalene in the UK. At least, that's what I see everywhere. ​@LivMeadowvalley

  • @mailelement1100
    @mailelement1100 2 місяці тому

    Love your sweater!! Maybe I can make one in my spare time?

  • @jenmu7870
    @jenmu7870 5 місяців тому +6

    yes, physicians often don't even know what pharmaceutical technology and biopharmacy are.
    pharmacists are the people that learn every little detail about it over years at the university.

  • @stephanied6711
    @stephanied6711 5 місяців тому

    Great video very interesting

  • @starchan2036
    @starchan2036 5 місяців тому

    Sorry just started the video but i cannot get over how cute your top is omg

  • @user-kc3lv3vx6g
    @user-kc3lv3vx6g 5 місяців тому +3

    Thank you for this video, I’ve been using tretinoin for 3 years now, a very low percentage didn’t help with my problems of acne, so my curology doctor prescribed me a more stronger one, my skin has never stopped peeling and is very dry to the point that I need very occlusive creams, but the heavy oils in them make my skin break out even more, I have stopped tretinoin for 4 days, the peeling has stopped, but I’m getting back the redness and little bumps that I had before using tretinoin, I’m just a mess, thinking on using adapalene to see if that works better. Thank you for your videos as they are very educative!!

  • @DesArtandInk
    @DesArtandInk 3 місяці тому +2

    Hi Michelle, have you ever looked into any of the data/research around the question of tretinoin and/or retinol being harmful to meibomium gland cells in the eyelid? I realize you are not an eye doctor but your ability to understand research and translate it to the general public is so appreciated. ❤
    I understand MB glands do wither with age on their own, and theres a body of thought that only oral isotretinoin has been shown to damage MB glands, but theres still the question/uncertainty around the possibility of topical reintoids doing the same, even if not directly applied to the eye area, and theres one video ive seen on yt from an eye doc that advises extreme caution and some eye docs recommend not applying to the face at all. A review of what literature we do have on the topic would be an epic video if you ask me! Especially since retinoids are becoming soo popular .

  • @daneroartworks
    @daneroartworks Місяць тому

    As a pharmacist who worked next to a dermatology clinic, I really love your videos! And you're 100% right. Pharmacists here have the right to choose and adjust the base and vehicles. Unfortunately since parabens fell out of favor and most bases (other than very hydrophilic ones) don't have them, the microbial stability is very limited to 3-4 months like you've said. We used an unguator for compounding, but even then you have to manually homogenize the powders and there is no chance you can get them to a fine enough particle size by hand for the best effect, especially with ingredients that require it (most formulations here are suspensions). A few times we've had salicylic acid creams where the crystals didn't dissolve properly and it was a nightmare to deal with.

  • @bethdahl3741
    @bethdahl3741 5 місяців тому +1

    Off topic, but I love your top! 😍

  • @spongebracket
    @spongebracket 4 місяці тому

    Super off topic, Michelle, your bangs are BANGINNN 😆 It's not budging, what did you use to set it 😅🤔

  • @cheezarose
    @cheezarose 5 місяців тому +1

    Tretinion and similar drug products are so hard to come by where I'm from. I have been struggling with acne my whole life and never once was this even suggested to me. I wish it was easier to get,since it would greatly help my skin for all the numerous conditions listed in your video.

  • @angelaayala2208
    @angelaayala2208 5 місяців тому

    I love your videos! It is so nice to hear information from the credible source and not the influencers who got their education from google! Could you please make a video explaining if you can layer other active ingredients with tretinoin. I love putting L’Oréal hyaluronic acid first or putting 10% glycolic acid first. My skin torelates it really good. But i am so afraid that if I layer other product on my face before or after tretinoin I will destabilize tretinoin formula rendering it being less effective. I could not find this information anywhere.

  • @Joerpg84
    @Joerpg84 5 місяців тому

    Instant subscribed! Love your content. It’s sad Stieva has been discontinued, and Retrieve just does not agree with my skin. I had tretinoin compounded and it burnt my face as I believe they messed up the strength as they changed it from 100g to 50g and 1 repeat and probably didn’t change the concentration

  • @A_sad_vegetable
    @A_sad_vegetable 5 місяців тому +7

    Perfect timing!!! I was considering whether or not to try to get a tretinoin prescription since using OTC adapalene daily hasn’t helped enough (been using it for over a year)

  • @sagebeauty
    @sagebeauty 5 місяців тому +6

    On an unrelated matter- I adore your top!

  • @LeanneP111
    @LeanneP111 4 місяці тому

    Now need a video on how to do the layering!

  • @Luna-1028
    @Luna-1028 5 місяців тому +1

    Love and thank you for all the research you do. With all your thorough information, my skin looks better than ever. Could you please do a video on how to fade scars from surgery. I have a scar on my nose from having skin cancer. Im self-conscious and it's very hard for me to go out without makeup. Thank you in advance, love your channel ❤❤

    • @mouse2390
      @mouse2390 5 місяців тому

      Silicone according to my plastic surgeon. I use silicone scar sheets on clean dry skin in the morning and silicone scar gel massaged in at night. You can also use vaseline but silicone is the only thing medically proven to minimize scars. Also never, never skip sunscreen...5 minutes of sun will turn that scar a red that you might never get rid of. I had a cyst removed from my cheek 6 months ago and my doc said full healing could take a year...it's doing great so far and I'm much less self-conscious about a piece of flesh-colored tape on my face than I was about that cyst. Nobody looks at you as harshly as you look at yourself--plus you've gone through skin cancer!--be proud of your scar.🏆♥

  • @chefbnguyen
    @chefbnguyen 3 місяці тому

    this top is unbelievably cute!! did you make it yourself?

  • @808mate
    @808mate 5 місяців тому +4

    Thank you. Always had a feeling the compound formulas were much less effective than the generics. Used a subscription service for a couple of years and it just gave me irritated skin. The generic just worked as intended, and with no side effects.

  • @deborah972
    @deborah972 5 місяців тому

    Hi love all your videos skincare routine have a wonderful christmas 🎉 😊 xx

  • @ntheobsn
    @ntheobsn 5 місяців тому +3

    I loved this video! I was using Agency and after learning all formulas have 4% niacinamide, with no option to remove it I realized it was not truly a custom formula. I told my provider I can’t use niacinamide she told me good luck and to go elsewhere.

  • @jedge7079
    @jedge7079 5 місяців тому

    Great video, thank you so much for all the effort you put into it. I used skin&me tretinoin/azeleic/niacinamide for about a year and the irritation never settled. I finally switched to Geek and Gorgeous retinAl and my skin has never been better

  • @TalitaCGO
    @TalitaCGO 5 місяців тому +4

    When I started treating my melasma, the doctor prescribed a drug containing tretinoin at 0.05, hydroquinone and fluocinolone acetonide. My skin didn't like it very much, but I could handle it by reducing the frequency (to a 3 day interval) and using a good moisturizer for sensitive skin. Now I use only tretinoin at 0.025 every day and my skin tolerates it really well. I still use the same moisturizer tho, which might help a bit.

  • @MyLoVeLyMaN
    @MyLoVeLyMaN 4 місяці тому

    I just discovered you randomly and have loved the knowledge you shows in this video. I know quite a bit about retinoids and all make sense and was wuite a satisfying video to watch! Last time I was in Greece I picked up tazarotene 0.1 over the counter by a cosmetic brand. Only used since a short time but it seems pretty intense - it is in a very moisturising formula but still getting the uglies of a strong retinoid (using a tiny amount over moisturiser only twice a week) I might try and get a prescription formula if I carry on with usage since I feel better about prescription. (and in the Uk are also muh cheaper than OTC/online derm service, as GP can often prescribe them)

  • @foxwaffles
    @foxwaffles 5 місяців тому +4

    Its just such a hassle to try and get a script. So I don't think I'll ever have access to it. Looking forward to your future videos in retinoids 😊

    • @samnicol9388
      @samnicol9388 5 місяців тому +1

      I just asked my regular Doctor, worth a try.

    • @oryxs
      @oryxs 5 місяців тому +1

      iherb has 0.1% differin adapalene gel.. I haven't ordered it myself yet but I'm planning to.

  • @nikki__west
    @nikki__west 5 місяців тому +7

    Michelle is doing the lord’s work

  • @ruthobrien4765
    @ruthobrien4765 5 місяців тому

    Love your videos as I'm a science nerd as well. But I am in the comments section to ask about your top which is totally amazing. Please let me know the band/creator ❤

  • @PilatesbyGina
    @PilatesbyGina 5 місяців тому

    Whoa. I get my compounded Tret thru Agency and my formula has those crystals twice now. When I asked they said it was fine and not a sign of issues. Chaps my ass. It has been the easiest way for me to get my Tret here in the US and I have loved my results. I am going to look into a different company to get it from. Ugh. Thank you Michelle for your excellent content!!❤

  • @floweringtulsi
    @floweringtulsi 5 місяців тому +1

    I would LOVE if you could make a video like this about hydroquinone

  • @user-je2se1yc4u
    @user-je2se1yc4u 4 місяці тому +1

    Thank you for your video

  • @noneofurbusiness5223
    @noneofurbusiness5223 5 місяців тому

    Wow, ur getting close to 1/2 million