Should you even use tretinoin? A scientific breakdown
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- Опубліковано 12 чер 2024
- Drug retinoids are some of the most powerful ingredients in skincare. So why would anyone use cosmetic retinoids? And are compounded drug retinoids the perfect middle ground between them? (No.)
I break down drug, cosmetic, and compounded drug retinoids, which one you should use, and bust a whole bunch of retinoid myths along the way.
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0:00 What are retinoids?
1:53 Benefits of drugs
8:23 Benefits of cosmetics
12:24 Which one should you go for?
14:14 Compounded drug retinoids
Does retinol in skincare even work? • Does retinol in skinca...
Blog post with more info and full references here: labmuffin.com/drug-cosmetic-c...
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🙋🏻 I'm Michelle, a chemistry PhD, cosmetic chemist and science educator, here to explain how beauty products work, debunk myths, and help you make smarter decisions about your skincare, hair and makeup!
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I have been using 0.25% tretinoin since my early 20’s. Originally it was for PCOS-caused acne. It sorted out the lesions and clogging pretty damn quick and I stuck with it - AND sunscreen of course. I’m in my 50’s now and apart from my pregnancies, I have used it every day. My complexion is much firmer and clearer than most women my age and basically, they’re going to have to tear it from my cold, dead claws when I’m dead.
😂
Do you get compliments for your skin?
I love this comment so much 😂
🎉🎉 Do you mean .025 or .25?
Did you notice a difference in wrinkles?
Michelle: "Guys, *STOP* bullying hyaluronic acid 😡😡😡 they are a *good* little active ingredient and they're trying their best and I am *proud* of them 😡😡😡😡"
Justice for Hyaluronic Acid! 😡😡😡
On the subject of hyaluronic acid, it would be very useful to know if, in a dry climate, it takes moisture from your skin. Would you be able to advise on that?
😂😂
Please I have the same question aboit glycerin @@leannepllpplplpbenn363
My skin doesn’t like it
I live in a place where 0.025% tret is over-the-counter and my skin is very tolerant to It... Using Tretinoin this past year has been great for the appearance and health of my skin. Never dealt with problems related to irritation... And my acne is 99% gone 😺
Ah, yes. How does it feel to be God’s favorite?
And which country is that?
@@noimnotakpoppfpsheacy2526most Latin American countries
Can it help dry skin?
Oh my gah I wish the US would allow that!
This has nothing to do with skincare, but your crochet top is just.... *chef's kiss*
Thank you!
Ma’am I’ve been SCOURING Reddit for this information - specifically around the compound formulas. This video is everything and more thank you SO much
Any good brands you've found since this video? I don't have my computer with me on my current contract so looking up the papers she mentioned is hard
Buena chama!
@@Nurse_Lucy sorry just saw this! I was just using dermaticas compound formula which I actually loved for the enhanced azelaic acid but I was curious if the tret was doing anything since (1 the treatments expired within like 2 months and (2 I was able to use quite a bit without dryness / flakiness (even tho my skin is super dry normally and esp dry with generic tret). I’ve since switched to generic tret and I feel like my skins making use of it better than it did w dermatica (tho that could definitely just be in my head).
@@SamFerro Hi, thank you for sharing this! I have started the Skin + Me compounded formula, and I feel like the added azelaic acid and niacinamide could be irritating my skin + making the tret less effective. I'm thinking to switch to pure tret, where did you get yours from? And what strength are you using? Thanks!
@melissatranfield4054 I have nothing to do with this comment, but I found it interesting. I get mine from nurx it's about the same amount of money but straight from the pharmacy.
you are one of my favorite creators. translating this scientific information into easily understood content is no small feat and you seem to do it effortlessly.
Thank you! I've worked really hard at it 😊
@@LabMuffinBeautySciencethat is why I love watching your content as well. Having been in the field, Micro and Genetics background, I know full well that knowing content and delivering it in a digestible way, to those without the same background (people are often so specialized that going even a step outside of their field can feel like foreign language acquisition) while delivering a conclusion that appeals to common sense, rather than manipulation and fear mongering, is rarer than anyone realizes. Plus, the hilarious cutaways, I watch for the hilarious cutaways too!😂
Yesss. Nt a big nerd bt I love anything & everything skincare esp tret n ss so having all these digestible info is sooo helpful ❤
@@LabMuffinBeautySciencewe love u!!! 🥰🥰
I started with tretinoin at the age of 16 due to acne. After 5 years I took a break but then returned to tretinoin until I was about 30 when I used oral isotretinoin for 10 months. After my acne was done I had read so much about retinoids that I chose to use them as anti aging. I tried different types of retinoids but went back to using prescription tretinoin five times a week, just a pea size and I moisturise to high heaven. You are absolutely right, the package is extremely important, I store them in the right temperature and follow the instructions on the package. I am 49 and I look like a porcelain doll. Of course SPS 50+ at least 2-3 daily.
I am no doctor but i have been reading about retinoids for 30 years and I know you are giving the best and most relevant information. Michelle you are an SPF angel sent to us. Thank you.
I’ve been storing my prescription tretinoin in the fridge. Is that ok???
I switched from a compounded tretinoin from Curology to a generic prescription tretinoin cream. There definitely is a difference. My dark spots are fading quicker with the generic tretinoin cream, even without the added tranexamic acid and niacinamide that was contained in the compounded formula from Curology.
The Curology formula wrecked my face. Things are much better with just plain tretinoin from the pharmacy.
I use a similar service from Australia called Software. I used compounded 20% azelaic acid, and another formula with 0.0185% tretinoin. Both products contained niacinamide in a hyaluronic acid base. I’ve seen moved on to generic brands (OTC 20% AA and prescription 0.05% tret) and there’s a lot less redness, warming of the skin, and irritation. My tret is 0.05 now which is almost 3x the concentration of my compounding formula and there’s no irritation for me.
@@ALT-vz3jn same I thought I was the only one. Used it for about two months and I could not stop purging. Purging should only last a couple of weeks
Same. Curology wrecked my face. Gave me PIE and after just stopping 1 day my skin is MUCH better. Never again will I use curology.
I’ve had the same experience with Curology vs generic tretinoin, since switching to the generic tretinoin my skin is so much calmer and I’ve actually been able to increase the concentration of tret with no irritation. My skin was constantly irritated and sensitive while using curology.
"It's a bit like hazing, but for molecules."
Genuinely laughed out loud at that one. Love your work Michelle.
😂😂 I had the same response and posted the exact same comment as you! Since you beat me by 22 hours, I deleted my post and gave your comment a thumbs up.
I just found her and love her video with poor Kenny and the fire!🔥 😂🤣. Then the hazy statement! Creative! Love it
Crazy good video Michelle. I often "feel" like medical professionals and researchers aren't always on the same page, and this was an excellent explanation without going into "doctors don't know what they're talking about" territory.
i seriously can’t get over how amazingly informative and helpful your videos are. They are so thorough yet easy to understand.
really informative without being confusing! being able to simplify info like this without dumbing it down is the mark of a great teacher.
Well, this video gave some clarity for my experience with Tret for a year. I tried all the tricks recommended to ease in and prevent irritation. For months, my skin was just very inflamed, irritated and dry. My skin never got used to Tret. I felt like a wasted a whole year. I have carefully tried the Cerave retinol and so far so good. I do have East Asian skin and often have reactions to things I try in addition to that. Tret is just too harsh for me no matter what I try.
omg someone else!! Every time I’ve tried tret my skin flips out no matter how long I try it
That was me w/ Adapalene... I'm considering trying it again, since I started Testosterone & my skin is more oily/congested than it was before. But it's definitely a gamble.
@@ZijnShayatanicaI've failed at rx retinoids a bunch of times. Using the ordinary pink serum as part of my routine has kept me going on
Brilliant mention of the “buffering” process around 12min. Super important distinction!
I used Curology's "custom" formula for about 6 months and then switched to the regular tube of tretinion. My Curology formula had 0.035% tretinion, and the regular tube was only 0.025%. I have to say that my experience made me feel that the tretinoin on its own was more powerful despite being a lower percentage, because I was getting the initial purge and sensitivity all over again when I made the switch! This does explain it, thanks.
Curology also presents a 25g container as a "2 month supply", when my doctor prescribes me a 20g tube of tretinoin as a one month supply...no wonder I always ran out of the Curology formula weeks before I was supposed to despite using the amount recommended! They do this on purpose, surely, because you can request your shipment early. More money for them.
what are you doing to use 20g in 1 month?! my prescription is a 25g tube and it lasts me almost a year
@@miss_jessTretinoin typically comes in either a 20g or 45g tube. I'm willing to bet that yours is 45g. If yours really is 25g I'd be wondering how on earth you could stretch that to a year. I can't imagine it being enough to be effective or applied evenly. I use a 20g one in about 6 weeks, but it's the amount I'm "allowed" to get per month. I have it in a low-ish percentage that I tolerate well and I put it on my neck as well as my face. Not a huge amount, but not the "pea sized" amount recommended for beginners.
Your videos are always super helpful, and this one has to be one of the most helpful ones you've made. THANK YOU.
You are amazing, tysm for the thoroughness and honesty here 🙏 I used tret for 4 years and it ended up leading to an outbreak of perioral dermatitis. Now my skin is so sensitive and reactive that almost any product can trigger the PD again (as well as other conditions now too) and it's SO hard to manage and treat, even with antibiotics. I wish people were better informed about the pros and cons of different actives, there's so much mystification in this industry.
I sympathise with you. I didn't use tret for as long as you but I tried it (0.05% once a week for 4 weeks) and I now have rosacea and the skin on my face is extremely sensitive. I regret it so much. My poor skin barrier 😔
@@sheridanbeverley9173I’m so sorry you went through that :( but yeah 0.05 is pretty strong as a starter
@@sheridanbeverley9173you are going through that***
@@sheridanbeverley9173Tretinoin obliterated and aged tf out of my skin, I even got a dry/raw patch that left a terrible scar. This all went away slowly once I stopped using it. If you live in a super dry climate and don’t have great water quality, please do not use tret. If you can’t provide the hydration that your skin needs, tret will make your lines and wrinkles WORSE.
Hi im sorry for you, did your skin healed?@@sheridanbeverley9173
hype! literally been on a lab muffin binge watch this week as a new sub
I have really sensitive skin, so it was hard to find an acne solution that worked for me. Tretinoin was surprisingly much more tolerable and effective for me than Duac and BHAs.
Another great video. Looking forward to the next two follow up videos. Especially the cosmetic retinoids. Always watch you !!
This was SO good!! The bioequivalence regulation explanation was fascinating 💡
This is my new favorite channel!!
this channel is a gem for dermatologists. thanks for scientific approach! i've subscribed.
Love your videos! I always learn a ton and come away from it feeling empowered to make better skin care choices!
I am Scandinavian and very pale. I always thought I had a bit sensitive skin but when I started with retinol and then switched to adapalene a few months later, I never felt any irritation, nor got any redness. I didn't really read much about "and I more or less slapped it on like moisturizer" (avoiding eyes) and then added another layer of moisturizer cocktails from hadalabo and cerva (two of my favourite brands) and at the end sealed it all in with a good layer of vaseline to make it penetrate deeply and went to bed. Still no irritation ever and my skin became 10 years younger within a year. I have now dialed down on the adapalene, mainly because it seems a bit of a waste to use that much, but honestly never had as much as an itch or a red spot.
Adapalene is so good! My skin reacted badly to tretinoin then I tried Differin (I had acne so I needed something). Differin changed the game! 3 months later, not much acne anymore, no irritation or redness and glowy skin!! I once couldn't believe my skin texture after I had washed it and hadn't applied my moisturiser yet. I looked at it and it seemed to have a "shiny" film and I was so weirded out because I thought I hadn't washed my face well. It turned out that was the texture of my skin LOL, very smooth and glowy even without products on. It's wild. I don't ever plan on giving up Differin especially since it's easily available here in the UK through a pharmacist.
I get zero irritation from tretinoin either, but I did with over the counter retinol. So odd haha
I started with tretinoin, but had too much irritation. Used adapalene for about two years with no irritation. Simple skincare routine. Switched to tretinoin about two months ago with zero irritation too minimal irritation and purging. The greatest part about adapalene - you can pick it up at any drug store.
@@Alex-dj9qjwhat brand do you use?
I think we only have Differin brand adapalene in the UK. At least, that's what I see everywhere. @LivMeadowvalley
Thank you Michelle for all the information, your hard work and time! 🧡🧡🧡
I just finished my MSc in biochemistry and I have always loved all things makeup & skincare… your channel is a mix of my two favorite things to geek out about! 💕
I love your comment and your profile picture, so that means I adore you! Same here!
You are such a blessing to this community! Thank you for your hard work! ❤
Thank you so much!
Thank you to yourself and all experts who helped. I'm going to try starting on Retinols this year and I have dry skin so I figure I need to go in easy! Meanwhile my Derm just rx me a prescription Trentinoin cream from a compounding pharmacy that's like $60 a month - so I'm glad I saw this video first!
Thanks for the breakdown Michelle! Great video as always❤
Really great, understandable video with a high scientific standard. Tank you so much ❤. We really need more of those type of vids wehen it comes to skincare.
Wow. This is by far the most informative retinol video I have ever seen. Thank you!
I personally will go with the prescription route 9 times out of 10. Cosmetics have the chance of working and you’re purchasing a product in good faith that it’s doing something, but you’ll never really know if it is because you’re not going to get skin biopsies after using a cosmetic. Prescription medication is a guarantee that this has been tested and approved for this reason so you’re not throwing your money and hoping for results.
Which ones exactly? The generic ones you get from the dermatologist?
Prescription tretinoin completely changed my skin within weeks. I have spent decades struggling with acne and texture. I spent so much money and time on otc retinols. They just don't compare.
Your video quality has improved so much! 🎉❤
Incredible video as always ❤
I really appreciate the work that you put into producing this insightful video. I was on the verge of trying out a compounded retinoid.. now I will just stick to the OTC brand name retinols I currently use 🙂. You just saved me a bunch of money and aggravation!
Thank you SO much Michelle - this is the MOST useful video on choosing retinoids I've seen yet! I also live in Australia and previously used Stieva 0.025% tretinoin. Is it now discontinued? I used Retrieve 0.05% which was too strong. What other brands are available in Australia? (It's very difficult to find any definitive information online.)
That was really interesting about the custom formulas! I've been wanting to try them to reduce my skincare routine, but it makes sense that it might not be as effective
This whole video is why I rely on experts like you 💜 also - sweater is SWEATERING 💜
It is isn’t it!❤
Thank you for you hard work on for sharing and explaining the information and your knowledge. I’m grateful for all your videos. Especially this one because we can see here and there everyone praising tret but almost nobody really discuss all the details and difference between the drug, the coumpounded drug and the cosmetic.
That explains perfectly why my Saint Derm (healed my acne with isotretinoine and supervised the long scar removal process) is so strict when it comes to the treti brand. It' s OTC in my country so he always insists: "IT MUST BE FERRER LABS. MUST MEANS MUST, I KNOW WHAT I' M TALKING ABOUT". I' m gonna share your vid with him so he can nod in peace for 17 mins😉. Thank you for your hard work. Happy Whateveryoucelebrate🧛🏻♀️🖤
Third!!! Love you, Michelle! You're irreplaceable.
yes, physicians often don't even know what pharmaceutical technology and biopharmacy are.
pharmacists are the people that learn every little detail about it over years at the university.
this was a great breakdown (and fascinating!)
I'm so glad that I am your follower from a long time. Thank you for your efforts!
Thank you so much for explaining all these things in depth!
Michelle, I *love* your crocheted top! Such a vintage look. It reminds me of a similar top that my grand mom hand crocheted for me which I wore in the 1970’s.
Omgosh!! SO much great information! Thank you!! ❤❤❤(And I LOVVVVVE your crocheted top! 🥰🥰🥰)
I really love curology because they educated me and informed me to use sunscreen (I know, I know). I started using over the counter products used from the formula they gave me and my skin has already improved sooo much.! My texture and hyperpigmentation improved…. But I ditched them for Dermatica. Curology’s face wash they gave me seems to have the shards or crystals mentioned, and I wanted tret so I made the switch. When I feel comfortable I’ll change to just tret and not the formula. Nice video and thank you for the information 🤗
how am I supposed to focus on the topic of video with this georgous crochet work fighting for my attention, it's just too good
I’ve been using all types of retinol for over 10 years. I started with pharmacy brands then moved very slowly through all the Australian retail products getting stronger and more expensive. I’ve used retrieve trentinoin 0.05% for every second day for two years, it’s aud $65 for 9-10 months supply.
I was looking for anti aging (negligible improvement) but for me the skin smoothing, reduced pigmentation, less single pimples and reduced sensitivity to lots of other things keeps me using it. ( I had very reactive skin, now I don’t, something I hadn’t heard about in retinol journeys)
I never buffer, I apply every second day and used tiny tiny amounts until I was used to a product but still can’t retinol everyday without a light flake.
I used Paula’s choice 1% retinol happily for a long time until they reformulated with dimethicone which blocked my pores gradually causing pimples.
I should have gone to trentinoin sooner, it has saved me a lot of money.
$65 for a 9-10 month supply seems like a very reasonable price
I started the same way as you 9 years ago, and second to the experience that my skin is far less reactive now and just generally happier. Actually, it IS talked about - quite a few specialists say that tret or any retinol really is making your skin over time thicker so-to-say, and this results with much less problematic skin. Thats why also tret is suggested for rosacea, but of course only introduces slowly over time from light concentration to stronger. I started with 0.3 over the counter retinol, now using 0.05% tret every 3rd day and retinal in between.
Does Retrieve also come in a 0.025% strength?
I have just started on Retrieve 0.5% . Am now using three times a week and so far, no issues. Really anticipating the journey. Costs me a lot less than the retinaldehyde serum I was using, too!
Would you be able to recommend a good sunscreen for Australian sun
Excellent video. Really informative. 👏🏻👏🏻👏🏻
Pretty and smart and honest and funny helped redeem my skin. Thank you for all you do! ❤
Amazing! So clear 😊
Michelle posts, I stop whatever I'm doing and get to learnin'!
Thank you for this scientific deep dive. I use a prescription service (Agency}. I have used prescription tretinoin for years and constantly battled irritation. My formula has Tretinoin, Niacinimide, tranexamic acid and Panthenol. If there are formulas out there that are separate for the $30 a month I payI would love to hear about it. Also I got so tired of layering all these different products on every night and many times would quit before completing the seven steps needed. With the Agency I use a moisturizer and their formula and it simplifies things. Love your scientific take on everything
omg this is just what I needed! Using 0,05% tretinoin rn but it‘s just waay too irritating. I can‘t find 0,025% either here in Germany but I wasn‘t too sure about the cosmetic retinoid. Can you maybe make a compilation of which cosmetic products (actual product) you find effective? thankyou!
Geek & gorgeous has a retinal and they do ship to Germany
You can buffer with a thin layer of moisturiser before, then use a tiny amount of tret with the dotting method
@@louk6848Michelle mentioned in a different comment that she personally mixes hers with moisturiser so that is definitely an option
Paula’s choice is good.
Have you tried tret micro?
Awesome video ❤ I always wondered if this custom formulas are actually tested for efficacy as a whole, or if they just assume it is, based in the tretinoin percentage.
I am using now a custom one just because is easier for the adaptation period. I can use it every day with small percentage and increase it gradually, and I don't need to measure the ideal amount.
But, my idea is to switch to prescription once I have reached a percentage that is available as a drug (I think minimum is 0.025).
On this topic, I would love to see next a guide on how to choose the best retinoid prescription 😊 There are so many options and brands, not sure yet what is best for me.
Thanks ❤
This video opened my eyes. Thank you!
Love this channel. Thank you!
Excited for cosmetic video!! X
This was so informative, thank you!
I'm intrigued by the science behind skincare. I appreciate how you make it palatable and easier to understand! I've been using OTC Adaplane for over a year now with no pronounced irritation. I considered trying out a compound formula from Dermatica or Apostrophe since cosmetic derms are sparse in my area, but now I'm reconsidering. Adapalene has been working for me and I have enjoyed the results, though my acne isn't completely gone. Maybe I should just stick to Adapalene while I search for a cosmetic dermatologist who can advise if trying a stronger, prescription-strength Adaplene or a low percentage of Tret would be the best next step for me.
Thank you for sharing your knowledge and hard work with us!
I'd say stick to what works, I was on tret before and it wrecked my skin. Adapalene gave me glowy and smooth skin after, something that tret never could. Plus no irritation 🤷🏻♀️ I don't want to discourage you but if something works for you, stick with it long-term unless it's damaging your skin in some way obviously. You can try and trial some tretinoin to see for a few months maybe
Hi Michelle, have you ever looked into any of the data/research around the question of tretinoin and/or retinol being harmful to meibomium gland cells in the eyelid? I realize you are not an eye doctor but your ability to understand research and translate it to the general public is so appreciated. ❤
I understand MB glands do wither with age on their own, and theres a body of thought that only oral isotretinoin has been shown to damage MB glands, but theres still the question/uncertainty around the possibility of topical reintoids doing the same, even if not directly applied to the eye area, and theres one video ive seen on yt from an eye doc that advises extreme caution and some eye docs recommend not applying to the face at all. A review of what literature we do have on the topic would be an epic video if you ask me! Especially since retinoids are becoming soo popular .
Thank you so much for including compounded skincare,
You are doing WORK. I completely agree with your observation vis-a-vis formula flexibility. I've tried prescription azelaic acid, hydroquinone, and tretinoin and ALL of them were in a white cream base that refused to absorb well (i.e., to my liking) and didn't layer nicely with anything else I use. So I dropped them. Life's too short for that mess.
I use a gel tretinoin, it's been great!
I should've also mentioned, I personally mix a too-high conc of tretinoin with excess moisturiser - I don't mind the reduced efficacy because my skin is so retinoid sensitive. You can also use it like a mask, and wash it off after 10 minutes (short contact therapy). Just in case you wanted to give it another try!
I have horrible cystic acne on my chin and use tretinoin but it’s not enough so my doctor prescribed me with azelic acid cream Lanette. Can you also use azelic acid cream 20% as a mask? I live in the Netherlands and azelic acid is only available in a Lanette cream, I’m afraid it will clog my pores, or do you think Lanette creme is save to use?
@@manoninamsterdam The Ordinary and Paula's Choice do sell 10% azelaic acid in the Netherlands. Is your acne hormonal by the way? I used to have the same issue, but it was purely hormonal for me, and taking probiotics (platinum by vitaminesperpost specifically) somehow solved my issue.
@@LabMuffinBeautyScience I did this once by accident and was surprised by how great my skin looked😂
Lab muffin is the best.
As a pharmacist who worked next to a dermatology clinic, I really love your videos! And you're 100% right. Pharmacists here have the right to choose and adjust the base and vehicles. Unfortunately since parabens fell out of favor and most bases (other than very hydrophilic ones) don't have them, the microbial stability is very limited to 3-4 months like you've said. We used an unguator for compounding, but even then you have to manually homogenize the powders and there is no chance you can get them to a fine enough particle size by hand for the best effect, especially with ingredients that require it (most formulations here are suspensions). A few times we've had salicylic acid creams where the crystals didn't dissolve properly and it was a nightmare to deal with.
good lordie you're ACE. Thanks - I 've tried explaining the difference betwixt the OTC and prescription , to my friends and 9 times outta 10 - just give up. Hence forth this vid shall be my go to. Cheers
Duch helpful information!🥇
Thank you for this video, I’ve been using tretinoin for 3 years now, a very low percentage didn’t help with my problems of acne, so my curology doctor prescribed me a more stronger one, my skin has never stopped peeling and is very dry to the point that I need very occlusive creams, but the heavy oils in them make my skin break out even more, I have stopped tretinoin for 4 days, the peeling has stopped, but I’m getting back the redness and little bumps that I had before using tretinoin, I’m just a mess, thinking on using adapalene to see if that works better. Thank you for your videos as they are very educative!!
Thank you so much for the amazing work! I love your channel and all the information you share.
I have acne and I tried out tretinoin for the first time in november. Before that, I had been using adapalene for the last 8 months and my skin was really better (I had an awful breakout at the beginning of the year).
I followed the steps from your tutorial video.
My skin started to breakout since the first application, I kept using it for 4 weeks, but it didn't got any better, only worse. So I stopped using it and I'm treating my acne with benzoyl peroxide.
Wondering if I should go back to adapalene and just stick to it. I wanted to try tretinoin because of the evidence in anti-aging effectiveness, but after this breakout, I don't know if I should try again :/
hahaha we did it, Joe! Thank you, excellent work, Michelle!
I have dry eyes and feel scared of worsening my meibomian gland shrinkage with retinols. You should do a video about the best bang for your buck skincare that isn’t retinol based! Thank you!!!
I’d like to know more about this dry eye thing you mentioned! -a fellow dry eyer
also had worsening dry eyes from using retinoids! Now I use tretinoin as short contact therapy (basically put it on for an hour in the evening then wash off with cleanser, do regular skincare after). that way I don't risk it getting anywhere near my eyes when sleeping. My dry eye hasn't been triggered since!
Me too. Too much meds going into my eyes now..
I used differin about a month ago. My eyes were so dry and hurting so bad it triggered a migraine. F*** retinol and tret..🤣
Unrelated to the video, but the color of your top looks so good on you!!
wonderful video! my coworker and i were just talking about wanting to figure out a good starting place for retinoids!
Perfect timing!!! I was considering whether or not to try to get a tretinoin prescription since using OTC adapalene daily hasn’t helped enough (been using it for over a year)
What about trifarotene?
@@lilivd4359what’s the upside?
Following you in all platforms
Thank you. Always had a feeling the compound formulas were much less effective than the generics. Used a subscription service for a couple of years and it just gave me irritated skin. The generic just worked as intended, and with no side effects.
I loved this video! I was using Agency and after learning all formulas have 4% niacinamide, with no option to remove it I realized it was not truly a custom formula. I told my provider I can’t use niacinamide she told me good luck and to go elsewhere.
Sooo good. TY Michelle 🤍
Tretinion and similar drug products are so hard to come by where I'm from. I have been struggling with acne my whole life and never once was this even suggested to me. I wish it was easier to get,since it would greatly help my skin for all the numerous conditions listed in your video.
I love your videos! It is so nice to hear information from the credible source and not the influencers who got their education from google! Could you please make a video explaining if you can layer other active ingredients with tretinoin. I love putting L’Oréal hyaluronic acid first or putting 10% glycolic acid first. My skin torelates it really good. But i am so afraid that if I layer other product on my face before or after tretinoin I will destabilize tretinoin formula rendering it being less effective. I could not find this information anywhere.
When I started treating my melasma, the doctor prescribed a drug containing tretinoin at 0.05, hydroquinone and fluocinolone acetonide. My skin didn't like it very much, but I could handle it by reducing the frequency (to a 3 day interval) and using a good moisturizer for sensitive skin. Now I use only tretinoin at 0.025 every day and my skin tolerates it really well. I still use the same moisturizer tho, which might help a bit.
Sorry just started the video but i cannot get over how cute your top is omg
Instant subscribed! Love your content. It’s sad Stieva has been discontinued, and Retrieve just does not agree with my skin. I had tretinoin compounded and it burnt my face as I believe they messed up the strength as they changed it from 100g to 50g and 1 repeat and probably didn’t change the concentration
Love your top!
Michelle is doing the lord’s work
Now need a video on how to do the layering!
I've been using Her's compounded tretinoin for about a year and half and my skin has never looked better. I used an over the counter retinal for about ten years before that and it helped, but I love tret! I'd switch to a non-compounded tret, but my insurance won't cover it (and won't cover a dermatologist for anything cosmetic) so I'm going to stick with Her's for now. I just turned 46 and have just a few fine lines around my eyes, it's all retinal.
Great video very interesting
Great video, thank you so much for all the effort you put into it. I used skin&me tretinoin/azeleic/niacinamide for about a year and the irritation never settled. I finally switched to Geek and Gorgeous retinAl and my skin has never been better
On an unrelated matter- I adore your top!
Thank you!!
Off topic, but I love your top! 😍
Love your sweater!! Maybe I can make one in my spare time?
I LOVE hyaluronic acid, and I say this as someone in my late 30s with acne-prone, oily skin who is VERY picky with my moisturizers because everything seems to either make me greasy or break me out. I also LOVE Tretinoin. Both are a must in my very basic skincare routine. In the evening, I cleanse my face with a gentle 2% AHA face wash, then I apply pure Hyaluronic acid serum on damp skin (even around my eyes ), and after that, I apply Tretinoin 0.05% cream (obviously not around my eyes). That’s it. I don’t even use eye cream because I’m prone to milia. If I need extra moisture around my eyes, around my mouth or anywhere else, I use Cetaphil’s lightweight face and body moisturizer for sensitive skin, as the last step, it’s the only budget-friendly yet effective moisturizer that’s worked for me since I was in college. In the morning, I wash my face with water, and the only product I apply is a broad-spectrum SPF30 oil-control sunscreen (Cetaphil or Differin brand). I rarely use make up other than lipstick and pencil eyeliner…full face make-up with concealer, foundation, eyeshadow, mascara and blush are reserved for special occasions, and I make sure to take them off with micellar water before cleansing. It’s been that way for almost a year now and my skin looks fantastic, I rarely break out unless it’s PMS time, and I have even skin tone, my pores look tight, no blackheads, no whiteheads, no fine lines. I only use Tretinoin every other night now. My skin doesn’t tolerate vitamin C, so I make sure to just get plenty of it through my diet. Side-note: cleaning up my diet, daily exercise, drinking enough water, eating plenty of fruits, veges, enough protein and healthy fats, along with completely cutting out sugar and processed fats like vegetable oil has worked wonders as well, both inside and out.
Such a good explanation! I’m glad you’re going to delve further into cosmetic retinols. I use prescription tretanoin, but I have to moisturize my face first or it’s too irritating.
I found a person on UA-cam who explained a dotting technique that helped me, you squeeze out a tiny amount (1/10 of a pea maybe even smaller) onto your fingers then dot it onto your finger tips then dot it around your face, it feels like nothing is even on your fingers but I saw results without irritation, then built qty up over time. Still only every second night as my skin flakes if used every night.
Wow, thank you for this informative video! i appreciated the section on compounded drug retinoids. Differin is so much cheaper and accessible than a tret prescription. How effective do you think Differin is for fighting wrinkles? I know Differin has research for fighting acne and less research for fighting wrinkles, while there's a lot of research for tret for fighting wrinkles. But Differin and tret are similar, so how much overlap is there for Differin to be anti-wrinkle? Thanks for your help and educational videos!
That's actually going to be the next video, tretinoin vs adapalene vs tazarotene vs trifarotene!
@@LabMuffinBeautySciencecan't wait!
I was handling .025 tret just fine for 3 years but my skin looked noticeably better as soon as I stopped using it.
Curology did wonders for my skin when I first started. After a year or so, the dermatologist increased the tret in the formula and I seriously damaged my skin. I tried all the tricks like the sandwiching, using once a week, we lowered the tret % twice, cutting out all other actives and exfoliation completely. It’s taken a year to get my skin barrier repaired and now I’m trying to slowly incorporate a retinol product. I’m scared to try tret ever again.