Does retinol in skincare even work?

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  • Опубліковано 12 чер 2024
  • Does the best skincare ingredient even work? Some scientists and dermatologists say there's no trustworthy scientific evidence to back up retinol. Let's look at the evidence for retinol, and why skincare science might look a bit sketchy.
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    0:00 The case against retinol
    1:04 What is retinol?
    2:35 The dang government
    4:33 Why isn't retinol a drug?
    5:34 Cash Rules Everything Around Me
    10:24 The evidence for retinol
    15:11 What about other ingredients?
    How to start on retinoids: • How to Start on Retino...
    Ultimate vitamin C guide: • Ultimate Vitamin C Ski...
    My skincare eBook: labmuffin.com/skin
    Article with more info and full reference list: labmuffin.com/does-retinol-wo...
    🙋🏻 I'm Michelle, a chemistry PhD, cosmetic chemist and science educator, here to explain how beauty products work, debunk myths, and help you make smarter decisions about your skincare, hair and makeup!
    Blog labmuffin.com
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    📺 RELATED POSTS AND VIDEOS
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    Article with more info and full references: labmuffin.com/does-retinol-wo...
    📖 Key references
    www.mdedge.com/podcasts/derma...
    doi.org/10.1177/1740774515625964
    doi.org/10.1016/s0190-9622(98...
    doi.org/10.1111/j.1600-0625.1...
    doi.org/10.1016/S0021-9258(20...
    Full reference list: labmuffin.com/does-retinol-wo...
    🧴 SKINCARE GUIDE 🧴 Find out more: labmuffin.com/skin
  • Навчання та стиль

КОМЕНТАРІ • 903

  • @GlamorousGamine
    @GlamorousGamine 7 місяців тому +1889

    Loved the statement that “only ingredients with robust clinical evidence work” is bad science. I’ll always remember the joke that there’ve been no peer reviewed clinical trials that parachutes decrease your risk of death while sky diving.

    • @LabMuffinBeautyScience
      @LabMuffinBeautyScience  7 місяців тому +164

      Yes exactly! There's even an article in BMJ on it 😂 www.bmj.com/content/363/bmj.k5094

    • @mushy470
      @mushy470 7 місяців тому +15

      this was so funny loll@@LabMuffinBeautyScience

    • @arianathough2070
      @arianathough2070 7 місяців тому +71

      Yes! Not to mention the conflict of interest about the companies often being the ones who fund their studies in the first place

    • @AnUrbanGypsy
      @AnUrbanGypsy 7 місяців тому +10

      @@arianathough2070We always have to follow the money.

    • @missknight9
      @missknight9 7 місяців тому +57

      “Parachute use did not reduce death or major traumatic injury when jumping from aircraft in the first randomized evaluation of this intervention. However, the trial was only able to enroll participants on small stationary aircraft on the ground, suggesting cautious extrapolation to high altitude jumps. When beliefs regarding the effectiveness of an intervention exist in the community, randomized trials might selectively enroll individuals with a lower perceived likelihood of benefit, thus diminishing the applicability of the results to clinical practice.” 😅👍

  • @DaniL-hr9xo
    @DaniL-hr9xo 7 місяців тому +2018

    From a fellow scientist, it's so cool to see a video like this where you don't always talk about the main topic (retinol), but you also explain how scientific studies and publications work!! ❤🙏🏻

    • @LabMuffinBeautyScience
      @LabMuffinBeautyScience  7 місяців тому +89

      Glad you liked it! I really enjoyed making it 😁

    • @mantolinez
      @mantolinez 7 місяців тому +36

      As a a person who finished a PhD thesis im Materials science a few hours ago, I agree😊

    • @leptonsoup337
      @leptonsoup337 7 місяців тому

      Wow. I wish I had a phd fesis.@@mantolinez

    • @myselfme7945
      @myselfme7945 7 місяців тому +5

      As a student of social sciences I absolutely agree!

    • @adjaniaguilar
      @adjaniaguilar 7 місяців тому +2

      Publish or perish 😅

  • @Neiyk00
    @Neiyk00 6 місяців тому +425

    Retinol worked so well for me. My skin was a disaster before using it. Now, after 2 years I literally get compliments about my skin. However, it’s a long term solution and definitely requires consistency to work.

    • @tabithahamby4693
      @tabithahamby4693 6 місяців тому +6

      So cool to hear! What form/brand worked for you? 😊

    • @elenamiasnikova5574
      @elenamiasnikova5574 6 місяців тому +23

      Right, I use one of the probably cheapest solutions with low % of retinol and love the results. After I finish this one surely will buy something with higher %

    • @GodlessCog
      @GodlessCog 6 місяців тому +44

      It was retinol and lactic acid for me. I am too young to tell whether or not it has prevented signs of aging but regardless of that, my skin is brighter and the texture is much smoother, and I hardly suffer significant breakouts anymore!
      It did also come with several lifestyle changes for me, though. Making sure I am hydrated, paying better attention to my diet, making sure I change my bedsheets more often, actually having a proper skincare routine where I previously did not have one... etc.

    • @youroverlordruler
      @youroverlordruler 6 місяців тому +10

      ​@@GodlessCogI can swear by lactic acid lotion (using amlactin). I'm already getting great lightening results and still improving four months using. I had done a chemical peel gone slightly wrong on my underarms three years ago, which left it dark brown (ironically, I was trying to lighten my black underarms). But my skin was too sensitive. I started this year with niacinamide cream but it kinda stopped working two months in using. But lactic acid is still steadily lightening the area!

    • @tsuyuasui7297
      @tsuyuasui7297 5 місяців тому +1

      ​@@GodlessCog what type of lactic acid are you using?

  • @wallycola5653
    @wallycola5653 7 місяців тому +1015

    Well done! Simultaneously informative, funny, and unhinged. Person having a manic episode in front of a cork board is a really good look for you

    • @hannahshark8080
      @hannahshark8080 7 місяців тому +50

      I mean, she's not wrong on the subtle conspiracy aspect

    • @thousandsofstories
      @thousandsofstories 7 місяців тому +55

      GUBERMINT was *chef's kiss*

    • @LabMuffinBeautyScience
      @LabMuffinBeautyScience  7 місяців тому +197

      Thank you! I was worried I didn't look unhinged enough, my hair products were working too well on filming day 😅

    • @jenniferd264
      @jenniferd264 7 місяців тому +3

      @@thousandsofstoriesI spit my coffee laughing at that 😂😂❤

    • @betchbetchington6019
      @betchbetchington6019 6 місяців тому +1

      Facts.

  • @_oaktree_
    @_oaktree_ 7 місяців тому +653

    Oh my god, as a librarian your section on how to search for and understand a study gave me life! I've taught these research methodologies and evaluation techniques to so many undergrads and it just gives me such pleasure to see this out in the wild, as it were :) And in the interest of helping consumers make scientifically-informed decisions!

    • @LabMuffinBeautyScience
      @LabMuffinBeautyScience  7 місяців тому +50

      Librarians are unsung heroes! ❤

    • @jessss27
      @jessss27 4 місяці тому +9

      I'm excited at the prospect that skincare/beauty might spur young people learning how to research critically

  • @miriam8376
    @miriam8376 7 місяців тому +335

    I’m a rhetoric teacher and I ADORE seeing you address all the important elements in finding reliable research and how that is crucial to drawing sound, evidence-based conclusions. I’m going to show my students this video as an example of what ethical and reliable UA-cam essays should aim for.

  • @noa-ix9pe
    @noa-ix9pe 7 місяців тому +397

    I never thought this much information could be crammed into my brain in such a short amount if time in such a fun way, mind blown, my bio teacher could never😶

    • @rubysresource
      @rubysresource 7 місяців тому +13

      I play most educational videos, lectures, and podcasts at 3× speed, but Lab Muffin videos deliver information at an equivalent pace on 1× 🤣

    • @LabMuffinBeautyScience
      @LabMuffinBeautyScience  7 місяців тому +56

      @rubysresource It's the ADHD 😂 Sometimes at my teaching job when a teacher is running behind, they get me to cover a lesson to help them catch up 😅

  • @prismological
    @prismological 7 місяців тому +125

    More Corkboard Michelle please. It’s fantastic energy

  • @who-is-eva
    @who-is-eva 7 місяців тому +139

    As a baby dermatologist (just started my first job last month yay) and a skincare nerd (who used to have terrible acne), your channel is such a well of knowledge for me, i think i love you

    • @mthalter
      @mthalter 7 місяців тому +26

      Baby dermatologist had me confused for a second lol 😂

    • @jenniferd264
      @jenniferd264 7 місяців тому +8

      Congratulations ❤😊 Best Wishes for a long and Happy Career!

    • @jenniferd264
      @jenniferd264 7 місяців тому +12

      @@mthalteromgosh….. it never occurred to me they could’ve meant Dermatologist for Infants 😂 till your post 😂😂😂 That’s Hilarious 😂😂❤

    • @PequenaNoobAmaPudim
      @PequenaNoobAmaPudim 7 місяців тому +2

      ​@@jenniferd264i legit thought that was the case lmao

    • @chiccavaquita
      @chiccavaquita 6 місяців тому +7

      @@mthalterI thought she meant she’s still in dermatology residency. A baby in her career 😂

  • @khadinewarrick
    @khadinewarrick 7 місяців тому +174

    This is the sort of content I hope for when some UA-camrs preface their videos by saying they've done "research" into a certain topic, specifically those that tout their content as "educational". Really an excellent video! It was super informative while also being easy to follow and entertaining. Thank you! I learned a lot!

  • @pedrokass2973
    @pedrokass2973 7 місяців тому +107

    you deserve an award for your effort teaching science with common sense and creativity. Confession: I sent a message to youtube to tell them how extraordinary your videos are. Dr. Wong you're an excellent chemistry youtuber/teacher and not bad actress, brava! Claps in form of likes please.

  • @blackrosenuk
    @blackrosenuk 7 місяців тому +101

    We need more cork board Michelle!
    Seriously, thank you! You have a talent to make things educational, informative, interesting, and funny. Your smarts and hard work really shine in this video :)

  • @gailkrumenacker2089
    @gailkrumenacker2089 7 місяців тому +168

    Excellent video!! So educational but still fun and not dry or too long! Wish more of my professors had been like you!

    • @LabMuffinBeautyScience
      @LabMuffinBeautyScience  7 місяців тому +3

      Thank you! 😊

    • @BU272
      @BU272 7 місяців тому +5

      I'm a professor and also wish I was more like her!

    • @Merim.
      @Merim. 7 місяців тому

      @@BU272
      ضًًة❤ص❤صضًضًًّّ❤❤❤صصككككككككككككككككككككككككككككككككككككككككككككككككككككككككص
      ص

    • @alexterieur8813
      @alexterieur8813 4 місяці тому

      @@BU272im sure you have your own qualities that she could learn from you!

  • @SchlichteToven
    @SchlichteToven 7 місяців тому +101

    I think a lot of people think being skeptical or going against the mainstream automatically makes them scientific. It's cool to doubt. I listened to an episode of a podcast that was all about debunking everything, and the host interviewed a dermatologist who'd written a book on how retinoids basically do almost nothing (I had a lot of moments where I really wish I could have directly posed some questions to the dermatologist because she didn't seem to be taking everything into account), and at the end, the interviewer smugly asks the dermatologist if she personally uses retinoids, obviously expecting she'd say "hell no!" But the dermatologist said she does use them, because they work a little!

    • @LabMuffinBeautyScience
      @LabMuffinBeautyScience  7 місяців тому +61

      I think that might be the podcast I referenced at the start 😅 Agree, there's a huge trend of edgy contrarian doctors at the moment ignoring all evidence beside clinical trial evidence, a few of the Science-Based Medicine writers have dubbed it "methodolatry" and it's a really interesting topic!

    • @SchlichteToven
      @SchlichteToven 7 місяців тому +12

      @@LabMuffinBeautyScience Oh, it reminded me of that podcast, but I wasn't sure! That was the first and only episode I listened to because the interviewer seemed like she wanted retinoids to be a scam because certain other skincare ingredients have been shown to be ineffective, so that must be applicable to all popular skincare ingredients. Methodolatry's a good term for it! People seem to like stuff to be disproven more than to actually do the work to figure out what's true.

    • @Hhbb.9
      @Hhbb.9 8 днів тому

      @@SchlichteTovenwhat is the podcast called?

  • @skinny0ne
    @skinny0ne 7 місяців тому +8

    wow your studies/trials explanation was amazing. I’ve never heard anyone explain it this well and with passion!

  • @StephanieLeighG
    @StephanieLeighG 7 місяців тому +83

    Since I know some people will only watch the first few minutes of the video and end up thinking she’s saying the exact opposite of what she’s actually saying, here’s the summary: 14:30

  • @sunmoon42
    @sunmoon42 7 місяців тому +103

    So much work went into this video! Both informative and fun

    • @LabMuffinBeautyScience
      @LabMuffinBeautyScience  7 місяців тому +9

      I'm glad you enjoyed it! Yes it was a ridiculous amount of work but I think it was worth it, I felt like the topic deserved a thorough treatment.

  • @evan-vd4fu
    @evan-vd4fu 6 місяців тому +12

    you are such a fantastic science communicator! such an underrated and important skill when research is constantly being twisted and misrepresented in media.

  • @themaverickofbeauty
    @themaverickofbeauty 7 місяців тому +12

    One of the best videos in the UA-cam skincare game! I loved watching this and learning about the practicalities of research. Thank you!!!!

  • @farahdibasonda6708
    @farahdibasonda6708 7 місяців тому +30

    This video is pure GOLD! As expected from the queen! Looking forward to more videos like this on other ingredients. Lots of love 🥰

  • @jozefwoo8079
    @jozefwoo8079 7 місяців тому +16

    I've never been interested in cosmetics but this is such a thorough and interesting insight into it. I'm always delighted to be shown the hidden complexities behind a topic. This is the kind of quality most information should be! Congrats!

  • @Sigurjon543
    @Sigurjon543 6 місяців тому +8

    Michelle your scientific communication skills are incredible and some of the best I’ve ever seen!

  • @CandeeseNotCandiss
    @CandeeseNotCandiss 7 місяців тому +3

    You've done it again Doc - one of your best to-date!
    thanks for the time, effort, drawings and humour you put into edumucating us!

  • @markzeddo6033
    @markzeddo6033 7 місяців тому +32

    It was so great to get so much context about the usage of retinol: about the publishing ecosystem in both academia and industry, as well as how to interpret the studies that there are, even though there aren't clinical trials. Also, the use of the corkboard was perfect!

  • @agiles6483
    @agiles6483 7 місяців тому +7

    Girl, you rock! This was your best video, it was clear and the addition of humor was genius. I have wondered about the lack of well designed, double blinded skincare studies, especially on more than a handful of people. I knew it was about research funding, but I understand now that it’s more than just the money.

  • @fsantos199
    @fsantos199 7 місяців тому +6

    Your content is so so so amazing! Never get tired of watching your videos!

  • @Kilicka123
    @Kilicka123 7 місяців тому +2

    Yay! I was so hoping you'd cover the Sci VS. pod. This was a great video

  • @LanaBana2931
    @LanaBana2931 4 місяці тому +1

    You’re my new favorite UA-camr. Just discovered your channel, and now I must binge-watch all your content. You’re amazing! 🙌🏾

  • @soozempen814
    @soozempen814 7 місяців тому +7

    Can't even imagine the amount of time and effort you put into this, so thank you!! My skin still isn't sure yet if it likes retinoids in any form, but this helps clarify (as much as it can!) why it seems some OTC products seem stronger/more effective than others. Much to think about.

  • @schibbolethsquad44
    @schibbolethsquad44 7 місяців тому +69

    Thank you so much for this video! It not only explains if, why and how retinol works but why and how science works. Clinical trials aren't the end all be all.

  • @terrigross1339
    @terrigross1339 7 місяців тому +2

    Thanks! This is so amazing to hear. You’re the only person I trust when it comes to skin care!

  • @dumatin
    @dumatin 7 місяців тому +1

    This was an excellent video! So well explained. Thank you for all the work you put into this.

  • @latifaayad3803
    @latifaayad3803 4 місяці тому +3

    Your board of crazy cracked me up---the messy hair, the smudged eyeliner---amazing. As academia-adjacent (creative writing PhD student) I LOVE hearing about how you've appraised the research. THANK YOU!

  • @whatreallyisart5898
    @whatreallyisart5898 7 місяців тому +3

    really good break down of why there isn't much high quality research into retinol and that things still can work without perfect evidence for it!! entertaining and informative

  • @YukiSatagawa
    @YukiSatagawa 3 місяці тому +1

    Michelle ur explanation and method to showing and presentation has improved over the years!! ☺️ It feels so easy to understand and know what’s going on around

  • @maziarjamshidi4505
    @maziarjamshidi4505 4 місяці тому +2

    This channel is what I've been looking for for so long... Accurate scientific facts instead of fancy doctors with paid products. Good job!

  • @anaverran3040
    @anaverran3040 7 місяців тому +4

    So interesting and informative. Thank you for teaching us.

  • @MrThatGuyYouForgot
    @MrThatGuyYouForgot 7 місяців тому +6

    Thank you so much for such informative videos!

  • @klosettchen
    @klosettchen 7 місяців тому +2

    Amazing video! Loved the information combined with the comedy. You have helped me so much in the past to get a deeper understanding of academia and chemistry! ❤

  • @BakamonNO
    @BakamonNO 7 місяців тому

    The work put into this video was awesome! Keep up the good work fam! 😄

  • @catleaf
    @catleaf 7 місяців тому +42

    this was such a good and refreshing video. the effort and passion you put into these really shows. thank you!

  • @kalindivictoria2771
    @kalindivictoria2771 7 місяців тому +14

    This video was awesome! As a psych student I loved the deep dive into research in the industry (or lack thereof)

  • @razielvalentine4076
    @razielvalentine4076 7 місяців тому +2

    What I like about you is that you’re not doing the typical “it works, trust me, bro” video. You actually encourage people to do their own research.
    Thank you!!

  • @taray8102
    @taray8102 7 місяців тому

    This is such an excellent video! Thank you for breaking the topic down.

  • @lonelyboyxo
    @lonelyboyxo 7 місяців тому +40

    I've been using retinol for almost 2 years now and my skin is FLAWLESS. Started at 23 (now 25) with Selfless by Hyram's retinol (0.2 + tranexamic acid + rainbow alge) for almost 1 year and half and now with Kiehl's retinol (0.3) x 3 times a week and i absooooooolutely don't regret it. Get yourself a Retinol, a moisturizer with Niacinamide and Ceramides to put on top, a Niacinamide, a Salicylic acid and a AHA serum for the rest of the week and BOOM! Bye-bye breakout, bye-bye lines, hello glass skin!

    • @birdlover7776
      @birdlover7776 6 місяців тому +1

      This sounds like a good regimen 👍

    • @betito5192
      @betito5192 5 місяців тому +7

      That sounds being 25🤷🏻‍♀️

    • @thehouseofnivara5710
      @thehouseofnivara5710 5 місяців тому +5

      ​@@betito5192 😂😂😂😂 come back to us after 10 years and kids

    • @y3sy3day
      @y3sy3day 5 місяців тому

      genuinely dont know what you are talking about, are you trying to say that all young people have glass skin?@@betito5192

    • @margodphd
      @margodphd 3 місяці тому +1

      Tbh when I was that age I could have used everclear and vaseline and I wouldn't have lines... because, you know,of the age 😅 That being said, starting sun protection and good habits early is super important... especially the sun protection part. A lot of skin condition is still genetic and metabolic, and perfect routine might still not give perfect results to people with different baseline. Enjoy the effects, just don't overdo it.

  • @happysponge0680
    @happysponge0680 7 місяців тому +11

    Loved this video! Especially the cork board 😂 can’t wait to see more about retinoids 👀

  • @ViktorDi
    @ViktorDi 7 місяців тому +2

    Great video! I definitely learned some new things about the industry and retinol itself! Thank you for your work as always.

  • @alansanjuliosutanto4240
    @alansanjuliosutanto4240 7 місяців тому +2

    Love this!! You could make a whole scientific article just to talk about this and publish it

  • @pb_and_nutella
    @pb_and_nutella 7 місяців тому +14

    Would love to see a video breaking down what you actually do and don’t need to do in terms of skincare, it feels like so much is a very expensive scam, and you’re kind of left to figure it out. Would love a “these are basics that do in fact work and everyone should do” and “these are the additional steps that can address specific common issues” video, for the skincare fed-up people of the world!

    • @EmyN
      @EmyN 7 місяців тому

      She has an e-book I have seen

  • @lauraemilyaustria4116
    @lauraemilyaustria4116 7 місяців тому +5

    this was so funny and suuuperr informative!!! i appreciate your insight in breaking down the science for ppl (especially as someone that didn't do so hot in chemistry class!) + giving us the deal on the research and studies aspect (and the government!!) 10/10 on the production, the graphics are so nice to look at, too 😂looking forward to the next video ❤👌

  • @devanshikotak4171
    @devanshikotak4171 7 місяців тому

    took me back to those chem classes oh my god MISSED THIS Michelle :( the way you communicate AMAZING.

  • @lindsay4111
    @lindsay4111 7 місяців тому

    Thank you for this video Michelle, I’ve always wondered about this topic ❤

  • @sophiarose8127
    @sophiarose8127 7 місяців тому +10

    “….as someone who owns skin…” priceless!

  • @nolankvn
    @nolankvn 7 місяців тому +59

    There was something on the skincare subreddits recently about the retinol in Paula's Choice and The Ordinary products being unstable or rapidly degrading. So, even if retinol does work, that's another thing I don't want to worry about. Also worth noting that prescription retinoids typically come in airtight metal tubes instead of airless pumps or dropper bottles.

    • @LabMuffinBeautyScience
      @LabMuffinBeautyScience  7 місяців тому +55

      Yep, I'll be discussing those points and more in the next video! 😁

    • @roses00000
      @roses00000 7 місяців тому

      how dare they

    • @mona0monik
      @mona0monik 7 місяців тому +2

      What's wrong with airless pumps?

    • @_oaktree_
      @_oaktree_ 7 місяців тому

      I have a prescription retinoid in an pump bottle. www.aklief.com/content/images/product-packaging-desktop.jpg

    • @ninaxu541
      @ninaxu541 7 місяців тому +1

      can i see that reddit thread

  • @pamylasworld
    @pamylasworld 7 місяців тому +1

    Another fantastic video, thank you for sharing your knowledge!

  • @victoriaachkasova8534
    @victoriaachkasova8534 7 місяців тому +1

    This video is fantastic! High quality scientific communication 👏

  • @amarug
    @amarug 7 місяців тому +39

    Very interesting video, instant subscribe! My experience: I have been using Adapalene for over a year now daily before bed and I can say my skin looks so visibly different, it's evident without the need for scientific imaging for quantification and also discounting for some amount of "self-percention-distortion-via-placebo-effect". I never tried "typical cosmetic" Retinol, I went straight for the more druggy-variant. 😅

    • @manojipereira9169
      @manojipereira9169 7 місяців тому +3

      Yep I just started adapalene and had retinization, so I guess that's my sign that it's working

    • @d.on.in.a
      @d.on.in.a 7 місяців тому

      ​@@manojipereira9169what is retinization?

    • @juliacastro8505
      @juliacastro8505 6 місяців тому

      yeah it took me a year, but my acne never came back

    • @user-bc5mz9bx5n
      @user-bc5mz9bx5n 4 місяці тому

      I did too. Why would I pay so much money for something less effective?

  • @benjaminsamaha4687
    @benjaminsamaha4687 7 місяців тому +10

    It breaks my heart how few viewers you have 😭
    I want you to get that ad revenue so you can make more videos and I can put them on while I do chores and errands

    • @LabMuffinBeautyScience
      @LabMuffinBeautyScience  7 місяців тому +4

      Thank you so much! The biggest bottleneck is the research part, the dream would be to hire someone to help with that... in the mean time, if you aren't already aware of it, I did 2 seasons of a podcast called Skincare School with Adore Beauty!

  • @EH012
    @EH012 7 місяців тому +1

    What a little masterpiece of a video. SO GOOD.

  • @Alice_Walker
    @Alice_Walker 7 місяців тому

    This video is awesome. Thank you for your service to science and beauty and common sense in general 👑

  • @azharel
    @azharel 7 місяців тому +7

    As a self-proclaimed student learning about skincare and having the benefits using Tretinoin your channel has been significant about getting what is useful and what is wasteful in skincare. Thanks!

  • @DancingThroughLifexoxo
    @DancingThroughLifexoxo 7 місяців тому +4

    Definitely does, nothing else helped my acne for years until I started trying various retinol. I didn't love tretinoin from gp as my skin was so dry if I smiled I felt it split. But I got one for very dry skin from paula's choice and it's slower to work but is healing my skin so well

  • @angelinebiswas7611
    @angelinebiswas7611 7 місяців тому

    FANTASTIC EXPLANATIONS! Very well done!👍

  • @tomlangford4078
    @tomlangford4078 7 місяців тому

    This was excellent, would love to see a labmuffin update on innovations in skincare research

  • @vicc19
    @vicc19 7 місяців тому +3

    Super interesting video, I've learned a lot, thank you! I didn't know, for example, that retinoids had two different categories. I, personally, prefer adapalene over retinol. I've tried both and adapalene had less side effects on me and provided the same results.

  • @MovieTvDrama
    @MovieTvDrama 7 місяців тому +4

    I spoiled myself when I scanned through the comments before getting to the evidence board segments, but I was still not prepared for the perfection that it is, communicating both the facts and the feeling. "That's not how companies think, they don't have skin." (6:48) encapsulates so much in this context and can be applicable in other circumstances as well.

  • @Pattii248
    @Pattii248 4 місяці тому

    That is the content i love. Thank you so much for your effort!

  • @juliabinford6500
    @juliabinford6500 7 місяців тому

    Loved the entertainment combined with accurate info about science!

  • @ky8519
    @ky8519 7 місяців тому +4

    Loved the crazy scientist vibe.you're my only trusted source of all things skin❤

  • @xXNekou
    @xXNekou 7 місяців тому +12

    I noticed some wrinkles on my forehead forming a couple of months ago and immediately I started using retinol serum every night on my forehead and I see a big improvement. So for me it works 🤗🤗

    • @SueRosalie
      @SueRosalie 7 місяців тому +2

      you're likely just getting the benefits of moisturisation and paying attention to a regular routine

    • @xXNekou
      @xXNekou 7 місяців тому +8

      @@SueRosalie nope, I always moisturized and had a routine before using retinol :) retinol serum is the only thing that changed and after using it for 6-7 months I see a difference

    • @raidexe
      @raidexe 7 місяців тому

      I break out sometimes if I use too much, but it’s helping my forehead as well

  • @e.dani.f
    @e.dani.f 7 місяців тому

    Thank you, thank you, thank you for your wonderful videos! The time you must invest in making them, and sharing your expertise at no cost, you are amazing! Every time I watch, I know I’m getting real, objective information from a credible source. Love it!

  • @JanineFalcon
    @JanineFalcon 6 місяців тому +2

    I am only part way through this video and I’m enjoying it even more than I thought I would. Your creative and teaching skills are ⭐️⭐️⭐️⭐️⭐️

  • @xx-yd5mm
    @xx-yd5mm 7 місяців тому +59

    In Japan, there is a quasi drug class that a lot of skincare is in where it's not like a medicine, but it is acknowledged to be something with a strong effect such as a vitamin C product. What do you think about this?

  • @onionluigi6795
    @onionluigi6795 7 місяців тому +13

    Great video but I have one follow up question. While I dont doubt retinol works in (relatively) short term improvement of skin but shouldnt it by speeding up the cell cycle actually make skin age faster? I mean cells having more or less fixed number of times they can divide and all that. I was searching for some papers about this but didnt find anything except a few dermatologists saying "no its ok".
    If anyone got sth please comment link

    • @VitalyGG
      @VitalyGG 5 місяців тому +4

      The Hayflick limit does not apply to skin cells because they are constantly being replenished by stem cells. A typical skin cell lives for about 27 days, but it is constantly being replaced by new cells from the stem cell population. This means that a typical human will go through many more than 50 layers of skin cells in their lifetime.

  • @cindysmallwood2695
    @cindysmallwood2695 7 місяців тому

    Bravo!!! SO entertaining and SO informative! Love it

  • @boka5290
    @boka5290 Місяць тому

    THANK YOU SO MUCH GOR THIS VERY EDUCATIVE VIDEO! I ENJOYED EVERY BIT OF IT! ❤❤❤

  • @MsLinoi
    @MsLinoi 7 місяців тому +5

    As someone in their 20s with acne prone skin, I believe that adapalene is superior to retinol. But that shouldn't be surprising☺️ I just wished it was available over the counter in the EU...
    It's difficult enough to find dermatologists without a long waiting list...

  • @traepalmer
    @traepalmer 7 місяців тому +36

    Great video. This echoes my experience with retinol, retinaldehyde, and tretinoin, as well: I've used all three, and they all produce the same result on my skin. Tretinoin just works a bit faster but is also more finicky to use in terms of dosing. And while any retinoid can make me ruddy-looking if I overuse it, tret can sometimes have this effect overnight from one use, so I still keep retinaldehyde on hand to swap in for tretinoin if I have an important event the next day and don't want to risk looking sunburned.

    • @MacielAnaLuiza
      @MacielAnaLuiza 7 місяців тому +4

      Yes, I have the exactly same experience as you.
      Retinoids works really well for me. I can feel the difference in my skin (really quickly) when I stop using.

    • @nado5918
      @nado5918 7 місяців тому +11

      Wow, it’s good to know that all forms of retinoids provide the same results in the long term. I have sensitive skin so I can only tolerate retinol, but I’ve been feeling like I’m missing out for not using tretinoin. Your comment gives me the reassurance that retinol is just as good as long as I stay consistent.

    • @traepalmer
      @traepalmer 7 місяців тому +1

      @@nado5918 there's variation between individuals due to enzyme polymorphism (thanks to @moskinlab for that terminology 😁), so my skin may just be unusually good at metabolizing retinol and retinaldehyde. I'm also only using retinoids for preventative antiaging and not to treat a medical condition or severe photodamage.
      But yes, on my skin, they all get to the same endpoint, the difference is just speed. I also have sensitive skin (DSNW in the Baumann system), and I think a lot of people who make pronouncements like "tret daily or bust" don't realize they have resistant skin and won't understand our skintype.
      Especially if you've tried tret and weren't able to tolerate it at any strength or frequency of application, I think it's fine to stick with nondrug retinoids like retinaldehyde or retinol. The alternative of leaving your skin in a perpetually irritated state just so you can say you're using tret isn't really sustainable long-term: you'll wind up with an even more impaired skin barrier which can paridoxically make your skin look worse or even "older" until it's healed.

    • @n.m.3995
      @n.m.3995 5 місяців тому +2

      I need Help. I use the inkey list retinol serum.
      It Hurts on my skin. Why?

    • @traepalmer
      @traepalmer 5 місяців тому +1

      @@n.m.3995 you may be unusually sensitive to one of the retinoids in the product or to something in the vehicle. Have you experienced such a reaction with other retinoid products?

  • @Shinobu553
    @Shinobu553 5 місяців тому +1

    Your videos are alwasy a pleasure to watch ⭐✨

  • @Koralgolster
    @Koralgolster 6 місяців тому

    Thank you! I like both your videos and Science Vs. podcast and was a bit disappointed when I listened to that episode.
    I needed your video

  • @Ima_meangirl
    @Ima_meangirl 7 місяців тому +3

    I think it works. I use it and it makes my skin look great.

  • @hooray4pie145
    @hooray4pie145 7 місяців тому +89

    Great video! As a life altering sufferer of many underfunded, undereaserched and critically poorly treated diseases, I honestly couldn't give two shits about whether anti aging skin care has been rigorously tested. 😅 Just food for thought.

    • @LabMuffinBeautyScience
      @LabMuffinBeautyScience  7 місяців тому +42

      Completely agree! It's so frustrating to see the chronic underfunding of research for particular diseases.

    • @foxwaffles
      @foxwaffles 7 місяців тому +14

      I feel you on the underfunded diseases. It's infuriating. I had doctors tell me adenomyosis is impossible unless you've given birth , yet when I finally found a surgeon specialist not only did I have endometriosis as we suspected but yep, I had nasty adenomyosis!

    • @LabMuffinBeautyScience
      @LabMuffinBeautyScience  7 місяців тому +31

      @@foxwaffles Ugh that's ridiculous - my excision surgeon told me adenomyosis and endometriosis go hand in hand, it's basically impossible to have moderate endo and not have some adenomyosis, and that he'll see me in 10 years to yeeterus. But yay for specialists who know their stuff!

    • @foxwaffles
      @foxwaffles 7 місяців тому +15

      @@LabMuffinBeautyScience omg no way!!! Thanks for sharing 😮 I had to travel out of state to see an endo specialist but it was ultimately the best decision for me. I wanted a hysterectomy and let him know during the pre-op consultation and he didn't argue or say no, he said generally speaking we have thought about it a lot already and he trusts his patients know what they want. Post op he was like you made a good call on that 😅

    • @hollykane6204
      @hollykane6204 7 місяців тому +20

      YEETERUS 😂🙏

  • @andiej7163
    @andiej7163 7 місяців тому +2

    Thanks for another great video 😊

  • @interruptivecow
    @interruptivecow 4 місяці тому

    You are doing gods honest work explaining to lay people how to evaluate scientific papers

  • @Dory_D
    @Dory_D 7 місяців тому +29

    Thank you! 😀 Please also do a similar video about if vitamin C (and all it's 1 000 000 different forms) actually work.

    • @TosyaChan
      @TosyaChan 7 місяців тому +3

      She's done it before

    • @LabMuffinBeautyScience
      @LabMuffinBeautyScience  7 місяців тому +22

      I did one on LAA but the one on derivatives is taking a while, partly because of the stuff I explained here - a lot of the data is supplier data and it's a mess to sort through! 😭 It'll happen

    • @Chewy635
      @Chewy635 7 місяців тому +1

      @@LabMuffinBeautyScienceI’m excited for this! I actually rewatched your LAA video a couple of weeks ago and looked for the followup on derivatives, and thought you’d maybe just moved on from it- I’m excited that it’s coming!

  • @risxra
    @risxra 6 місяців тому +24

    Haven’t finished the video yet but the cutaway to the conspiracy board + “as a person who owns skin” sent me😂 Also love how thorough your explanations are of how clinical trials and studies work!

  • @Cosmohealthclinic
    @Cosmohealthclinic 7 місяців тому

    Loved your creativity and efforts 👏 ❤

  • @user-jv9xb5wz5c
    @user-jv9xb5wz5c 5 місяців тому

    I am Impressed youre one of the few who actually Critisize Studies and not blindly use them.
    Thnak you so mich its a instant sub

  • @froufroudeluxe
    @froufroudeluxe 7 місяців тому +4

    This should be interesting!

  • @alicegaiba
    @alicegaiba 7 місяців тому +10

    Thanks to this video I now know that my skin is made of lasagne. As an Italian it was a vital information for me to have. Can't wait to find out if my hair is made of spaghetti

    • @LabMuffinBeautyScience
      @LabMuffinBeautyScience  7 місяців тому +1

      I did actually use a "hair is spaghetti" explanation in this video 😅 ua-cam.com/video/-_3P3OGVzSA/v-deo.html

    • @alicegaiba
      @alicegaiba 7 місяців тому

      @@LabMuffinBeautyScience omg I had even watched that video but forgot about the spaghetti metaphor 😅

    • @LabMuffinBeautyScience
      @LabMuffinBeautyScience  7 місяців тому +1

      Lab Muffin Subconscious Science 👀

  • @islandsbamboo5160
    @islandsbamboo5160 5 місяців тому

    thank you! thank you thank you!
    appreciate your honesty!

  • @nostromofidanza1502
    @nostromofidanza1502 7 місяців тому

    Really great video. I'm a sucker for cosmetics being examined scientifically. Looking forward to the next video!

  • @nero1747
    @nero1747 7 місяців тому +8

    From my own experience, a month after adding retinol to my routine, I've had people I know notice and ask me what I had done to my skin, without me saying anything.
    Do with it what you want

  • @elizabethcheatham2727
    @elizabethcheatham2727 6 місяців тому +4

    Overall, I personally think retinol works to improve your skin. I don’t think it’s a miracle ingredient, but I think once you get over the adjustment period, your skin looks better overall.

  • @MRa-lh2nw
    @MRa-lh2nw 7 місяців тому

    awesooome! waiting for part 2 ❤

  • @skleroosis
    @skleroosis 7 місяців тому +1

    What an excellent science communication video! Well done! (Also from a fellow scientist)

  • @mushy470
    @mushy470 7 місяців тому +3

    9:18 btw this is what lisa eldridge did, she tested using her cleanser against nothing and then showed hydration levels. It could entirely be down to the water and not her cleanser and that is not mentioned but the "clinical trial results" are mentioned so many times in her marketing

  • @nova_beam
    @nova_beam 7 місяців тому +9

    I’m really interested about learning more about retinol and how it works in this easy to understand format. I’m not a scientist or chemist so I really value information like this. I can’t wait for the retinol video and must go back and rewatch the other video about choosing one. Recently I’ve been using Naturim’s Retinaldehyde cream serum and wondered if their clams that retinal is a more broken down version of retinol that absorbs better into the skin is true. I hope I can learn the science behind things like this so I can make more informed choices.

    • @traepalmer
      @traepalmer 7 місяців тому

      ​@@jehorigby8778prescription retinoids aren't universally cheaper: I pay $70 a tube for tret, and a lot of retinol and retinaldehyde formulas come in way under that.
      In fact, really the only way to get prescription retinoids much cheaper is to get them prescribed for a medical condition (e.g., acne) and to have health insurance that will cover that usage. Almost no private insurers will pay for retinoids prescribed for cosmetic use, and not all doctors are comfortable with falsifying a medical condition in a prescription in order to have it covered by a patient's insurance.
      There is also the option of importing them from overseas without a prescription, which risks safety issues with the product or confiscation by customs. They can also be purchased physically if one visits a country that sells them OTC (e.g., Mexico, some Southern European countries) in person, but there's still a risk, albeit minor, of them not being allowed past customs.
      Adapalene 0.1% is really the only drug retinoid that's on-par pricewise with nondrug retinoids like retinol and retinaldehyde, and it's now inexpensive because it's OTC, but it's only really been studied at the 0.3 % strength for antiaging, and that strength is still prescription-only, so would suffer the same pricing and access issues.
      So unless someone is using a particularly expensive retinol or retinaldehyde formula or has a doctor willing to write a prescription for a retinoid for a medical condition and this is covered by their insurance, getting a prescription retinoid is often going to be the more expensive choice.

    • @nova_beam
      @nova_beam 7 місяців тому

      @@jehorigby8778 i understand a lot of the basics but I just want to know the difference between retinol and retinal. They appear to be similar, even in name, and I just wondered if one absorbed better than the other. The Naturium product was interesting to me because it uses retinaldehyde instead of retinol. Some “research” has suggested this is a better treatment than retinol. I don’t really consider the $30 dollar cream expensive, but a trip to a doctor to get something prescribed is definitely out of my price range.

  • @flexibezt
    @flexibezt 7 місяців тому +1

    Love the creativity ❤❤❤

  •  5 місяців тому

    Wow. Amazing video, seriously, you put a lot of work into that. And thank you. I heard that podcast and it confused me! Thanks for clearing it up. Consider me a new subscriber!