Rapamycin study donation link: bit.ly/3QwugRx Join me over on Twitter: twitter.com/BradStanfieldMD Patreon: www.patreon.com/bradstanfieldmd www.donotage.org/products | Use code CheckWithYourDrFirst for 10% off
This reminds me of when you said you wouldn’t take curcumin. Apparently, curcumin helps the body to maintain it’s natural glutathione production as opposed to many other antioxidants which caused the body to down regulate production of glutathione and super oxide dismutase. I’ve seen that study in several videos by others so I was confused when you said you thought there was no point in taking it.
Hi Dr Stanfield. Do you have anything to combat gray hair? Mine occasionally reverse themselves (have hairs that are gray at the end and black at the bottom) but I'd love to know if there's something i could do to influence it
@@thev3432 Right, so he doesn't need it yet. But i was just wondering if there were any supplements that have been shown to help. Someone below seems to think the NAC is helping reverse their graying
My Doctor is a Professor of Neuroscience at a large University in America. He was impressed with this study, I suffer Long Covid from Delta last October. He put me on 1,800MG of NAC in split doses daily, and 3000-4000MG of Glycine to be taken with the NAC same time. Alot of my Back, Joint, Muscle pain is gone now. The Glycine he said at 3000-8000MG really calms the Brain, he was right, I can feel the calmness. Dr Stanfield Thank You for your tireless efforts to find ways to help the sick get well and the well stay well.
Been taking NAC for 6 months. I was 50 years old but since starting NAC I've lost years, feeling and looking younger. Unfortunately I'm now 8 years old and can no longer drive....thanks🤷🏼♂️
I’m 78 years old, female and tried the liposomal glutathione which you mention was not really the right product. I would like very very much to get your recommendations for the brand of NAC and glycine.
I have been talking it since the pandemic started. I had horrible uncontrollable asthma and was taking super strong steroids. I started 1000 mg 3x a day NAC and in months I did not need an inhaler or steroids. I stopped Nac and each time I felt my lungs weaken and need inhaler. Now I'm back on it breathing beautifully by the grace of God
Is 3000mg the dose that only works for you? Have you tried lower doses? I have asthma also, I'm taking 700mg of NAC + 600mg of glycine. I've only been taking them for a week and have noticed improvement, I'm wondering if i should up my dosage?
@@INTJ82 I started taking 600 mg 3 times a day since I ran out ans have not been able to find the 1000 mg pills and I have noticed a HUGE decline in my lungs and breathing. So definitely the 1000mg 3 times a day was the sweet spot for me. It's day and night difference. There's probably maintenance at low dosage and healing at higher doses. I would definitely up the dose at least for 1 month and see how you do. I did not have any side effects except happiness from not having to struggle breathing all day. Let me know how it goes!!
I would suggest combining NAC with glutathione already since at your age you really have low glutathione in your body already which precursors like NAC maybe have a problem converting enough for you already
I had irregular heart beat and was put on 50mg Metoprolol per day. Even so, some days my pulse would still beat irregular. It was frightening actually. Forget how and why, but I started taking NAC 1000mg supplement only once a day. 2 months later I notice my pulse is always regular, so I reduced Metoprolol by half, and for 6 months my pulse never miss a beat. The dose recommend on the NAC bottle is 3 times what I take. Thinking now I will stop Metoprolol completely. Maybe my heart just comes good on its own or maybe the NAC... cant be sure. I am thinking the NAC reduce my blood pressure which in turn helps my heart beat. I am 72 and always worked hard as a Plumber and drank a lot of booze in the old days. Now a reformed drinker and smoker and have a healthy respect for God.
@@trollking99 Interesting. Its possible I suppose as it was never fully tested and rushed onto the scene as it was. As a latter stage COPD victim of asbestos, my doctor never pressured me to get the vax as there was a chance the small amount of virus injected could make my case worse. So I never ever had it and never will. The weird part is, my sister and husband had all 5 vax doses, and he got Covid twice and she once. Go figure. I think the best way to avoid it is less contact with others = less chance to get it.
@@trollking99 I also developed heart issues after my second vaccination. I started having inner vibrations as well and continue to deal with them daily. As I type this I’m wearing a heart monitor and hope to get answers soon. I was active and very healthy before. Now my quality of life is 0 and I’m still fairly young.
Been on 600 mg. NAC and 500mg. Glycine daily at night for two weeks. Lost 10 pounds. WAKE up hungry. Double my energy and concentration. A home run as far as I am concerned. Maybe a new fountain of youth? You are what exactly the medical profession needs. Unbiased information for your patients. God Bless you 🙏
@@douglascyr7627 Hi Douglas. I bought nsc from eBay. When I took 700 mg, 1 capsule, I feeling somewhat confused, just a bit and anxious... What do you think, is it usual thing? 2) do you still having that NAC?
I agree, and I'm still in my 30's but due to some health problems have become invested in looking at the most recent research. I'm not necessarily looking for aging related assistance yet but having the information is useful.
I started taking NAC during 2020. A doctor from Med Cram, Dr Sheult, pondered the health of taking NAC, so if you got covid, you could fight it. Along with vitamin D. I have been taking it ever since, I am 60. I have lost 35 pounds. With potty training my dog, walked a lot. Also started putting a squeezed lemon in my large water bottle. All the above caused me to lose that much weight. I am 60, post menopausal, on Hormone replacement therapy. Go figure, you can lose weight after MENOPAUSE.
Nac was shown to cause cancer in mice. The mechanism is that nac prevents the death of cells due to ROS, however these cells that "should" have died go on to become cancerous. Get a checkup.
Hello Jean, I just added NAC to my supplements. I’m 63 and post menopausal also. Losing weight after menopause- you are an inspiration! I was wondering what dosage of NAC you are taking? I started at 600 mg but wonder if that is enough. Thanks!
I lost 25 lbs at 63, low carb with intermittent fasting. It wasn’t even hard and I’m not on hormones. I think the difficulty of losing weight as you age is exaggerated.
Dear Jean: nac has reduced my pain level more than taking 1000mg of vicodin. I am in my second week of taking nac and am moving to the point of not needing pain medication. My wife is also taking nac. She is taking 1200mg daily. Her weight is 154 and hopefully she can soon reduce her pain medication. Just not yet. I half the time will double the dose of nac to 2400mg. Am also taking vitamin k2 + d and am removing atorvastatin as blood fats improve with the k2. Do not immediately take a double dose of k2 right away as I had a trip to the emergency room. Doubling up nac has no immediate effect. Don't do as I do in any case. Am below 200lbs for the first time in 30 years but not because of nac but because I am moving away from carbs to a keytonic diet. Am 75.
After seeing your video I started taking 1 gram each of NAC and glycine 3x per day. It has caused a major improvement in my brain fog symptoms that I've been struggling with for years. THANK YOU!!!
Age? I'm 75 and trying to equate age with NAC/Glycine daily dosages. I had triple bypass surgery last October and am doing great . I've been taking 600mg NAC twice daily but not Glycine. After seeing this vid I'll add Glycine with the NAC. Cheers, Bob
Brad, super good news on research studies this week using NAC with results that were quite impressive. The studies will soon be Peer Reviewed and likely be reported in both Lancet and NEJM. Your video on NAC and Glycine is yet another big positive in the medical world this week. Keep up the good work Chap.
I took NAC when I had the delta strain covid about 10 months ago. It is a supplement on the “ Americas Front Line Drs. Protocol. 💐🙏🏽😍 My health care provider said, “take NAC 3 times per day. I’m 68.
mmm, thanks for the understanding around why we shouldn't mess directly with glutathione regulation and instead focus on providing the building blocks. I had never thought of Reductive stress, but makes a lot of sense.
Thank you Dr. Stanfield for opting for a community funded research and therefore having that amazing freedom to be unbiased, and to not have to walk on eggs as it were, around what large biomedical companies dictated to be "the science". Scientific research needs to be unaffected by politics, and systems of regulation and funding which are poorly set up resulting in incentivizing managing the symptoms and not treating the molecular causes of conditions. The work you do on proper informing of people on molecular biology and gerontology is commendable in itself, too. Wishing you all the best, and to hit that mark for funding of your own research.
Welp, I just turned 45 and have been taking NAC and have done several extended water fasts, my record has been 60 days straight. I will be adding Glycine until I hear otherwise, thanks very much!
I'm 47 and GlyNAC is life changing. I feel like a different person, and weirdly enough, I stopped snoring. It feels like my throat is more opened or something.
NAC is a reducing agent that lowers the viscosity of mucus in the throat, It's widely used as a drug to release slimes in your nose and sinuses if you have a cold, flew or so. So what you feel makes perfect sense.
Dear Brad, I've watched a few of your videos now and really like the clear way you describe this science. Its obviously entirely science based and you consider all the evidence and admit when the science is not clear. Can i just say that, perhaps because im older, i find your delivery a bit fast for me to readily take in all the information that you are imparting. I dont want to criticise because you are doing an incredible job and i've learnt so much. Just a suggestuon for you to consider. PS i dont know if theres any research on this, but from watching a lot of young people, I feel that these days you are speaking faster. But this may just be that i am slowing down generally and its a relative thing. I dont know. 😊 Take care, all the best and as a fellow Kiwi, am very proud of your valuable contribution
Something that helps is to tap the settings icon on the upper right of the video. When the box pops up, tap "Playback Speed." Then you can pick the speed you want the video to play. You can speed it up or slow it down.
I use "Video Speed Controller" add-on in Firefox and Chrome. It works well for slowing down fast-talkers and is also great for speeding up slow videos.
Great research and maybe explains why in my experience a lot of health conditions emerged after I turned 55. After Dr Sam Baileys recommendations a while back I started taking NAC and feel a lot of positive benefits alongside a low carb diet I now feel a lot better at 63 than I did at 55.
Hi, can you please give me the dosage of glycin and Nac. I have ordered this 2 and vit C . Im 42 and starting to get wrinkles so i decided to give it a try! Anyone can give me dosage recommendation and how many times per day! Appreciate your answer!
I'm only 32 but have started supplementing with NAC and Gly and it's been the most positive experience from any supplement I've ever taken. It started day one! I also have chronic sinus pressure and issues that not even precipitation sprays would help and this combo has me breathing clearer than I can remember last. I'm sleeping through the entire night now too and I attribute that to better breathing.
We need more info as you can see by the comments. I also suffer from severe allergies and sinus issues. Dosage and other supported info would be helpful
Hi, can you please give me the dosage of glycin and Nac. I have ordered this 2 and vit C . Im 42 and starting to get wrinkles so i decided to give it a try! Anyone can give me dosage recommendation and how many times per day! Appreciate your answer!
After reading the study, I found the reduction in Triglycerides to be over the top statistically. Even though this study excluded those with triglyceride problems, this is an improvement equal to or more than the statin market. No wonder the FDA wanted to make NAC illegal, so that it could be monitized.
🎯 Key Takeaways for quick navigation: 00:00 🧬 *Introduction to NAC and Glycine Study* - Understanding the shift in thinking about oxidants and antioxidants. - Oxidants as stress-induced survival signals. - The role of glutathione in oxidative stress and aging. 01:51 🧪 *Glycine and NAC as Building Blocks for Glutathione* - Glycine and NAC as building blocks for glutathione. - How aging leads to glutathione deficiency and elevated oxidants. - The potential of glycine and NAC supplements to restore glutathione levels. 03:00 📋 *Study Design and Participants* - Overview of the study design, including duration and goals. - Inclusion criteria for older adults in the study. - Red flags regarding the study's exclusivity. 03:55 🧪 *Study Dosage and Primary Outcome* - High dosage of glycine and NAC supplements. - Primary outcome: Glutathione concentration in muscle. - Comparison of glutathione levels before and after the 16-week study. 04:51 🏃 *Effects on Mitochondrial Function and Physical Function* - Improvement in mitochondrial function due to supplements. - Increased gait speed as a measure of physical function. - Positive effects on aging-related physical decline. 06:00 ⚖️ *Balancing Oxidants and Antioxidants* - The importance of maintaining a balance between oxidants and antioxidants. - Concerns about direct glutathione supplementation. - How glycine and NAC supplements avoid reductive stress. 06:56 🧪 *Study Limitations and Future Research* - Acknowledging the limitations of the study, including its size and criteria. - The need for longer-term, larger-scale studies. - The potential for age-adjusted dosage of glycine and NAC supplements. Made with HARPA AI
Im a chemist and was really sick with joint pain, headaches infections and anxiety for 4 years… Long term fasts / nac / garlic / kefir and curcumin were the strongest things that helped me. Another thing was removing caffeine and dairy consumption. Nowadays Im quite healthy. 🙈 Just add garlic often and take some nac once in a while.
@@supernice_auto most likely autoimmune issues (i have same)I do some of what this chick does/did and they work especially Long fasts (i.e. 4-5 days per month, or couple days biweekly) NAC also really good, Glycine probably good (especially for mood, in my case anyway) and garlic/unions are also good. BTW curcumin is the most overrated supplement out there, together with Chia seeds. In my case they were both bad (not horrible, but bad) and I'm sure they are not any good for anyone, but people use other supplements with them and think that benefits they are getting are coming from those two (Both Chia seeds and Curcumin were inflammation inducing for me, which exactly what you do not need lol). Flax seeds are really good and have anti-inflammatory and anti-cancer properties as long as you use them with yogurt or A2 milk, not the garbage milk from grocery stores.
@@supernice_auto it was autoimmune stuff due to bad sleep, jaw clenching because of my breathing issues ( broken nose years ago) and gluten causing inflammation ( nasal turbinates were swollen too ) not breathing and thick mucus caused so many issues which NAC is great for, I had headaches after each meal. One year after this comment Im even better. Lowered gluten, still take nac not daily but few times a week. And I take vitamin b, magnesium and fast every few months for few days. I feel great.
If you take protein powder and collagen daily be sure to check the ingredients. I ordered a bunch of Glycine and NAC pills only to find out the protein powder and Collagen I take contain a combined 3,500mgs of glycine.
Beyond ensuring that we have a balanced healthy diet, I wonder if obsessing about the next wonder supplement wastes more precious life than we might gain. Supplement manufacturers and UA-cam bloggers probably have much more to gain from this than we do.
Glycine and glutamine in a 2:1 ratio help the body to creat glutathione in the cells. Taking it orally or through iv is bad because glutathione also mobilises mercury into cells when taken orally, making a person sicker over time.
I take this everyday , among other supplements and been on clean keto and IF Im down 80 lbs since last oct of 2021 and I feel so good I sleep so good and I'm just so healthy it's crazy
Congratulations! Was there something about this combination of supplements that enabled you to do IF and keto and lose the weight? More energy? Feeling of well being, stress resistance?
Dr Stanfield - great video and thank you for the summary of the research. In my opinion, as a researcher myself, I prefer the exclusion criteria they applied. They excluded individuals with health risks that could skew or interfere with understanding the impact of the substance on an aged adult with a "normal" metabolism. So in fact, I do think it is applicable to the general aged population. As a Dr., you are probably more focused on individuals who are ill or in a diseased state, and I respect that perspective. But first things first, lets find out what it does without the disease state.
Maybe NAC fuels cancer too? It could be, right? We do not know in fact and we do not know what NAC does in ill people, illness which have the most of people in der midages. Would you share my perpective?
I have intuitively taken NAC and glycine (as a sweetener for tea) for over a year now. I'm still young but, as a scientist myself, I see the potential of these two supplements. Great video!
Great video Brad! I was already taking NAC and now I’m going to add the Glycine. It’s always great to add supplements to my stack that are actually CHEAP! Win win! 😊
@@snowyowl6892 It generally comes in a large container with a scoop. The common recommendation is one scoop, about 5 grams per day. It dissolves pretty well and doesn't have much taste.
IMPORTANT NOTE the most effective way to clear oxidative stress and have a cellular cleanse is from prolonged fasting.. that’s the first line of attack we should ALWAYS take before taking anything
Fastibg results will be more optimal if one enters that state with a high level of glutathione. And high B vits and mineral status. Am of the opinion that chronic vegans probably should not fast as they are likely too depleted already Have seem them try and have terrible outcomes.
I have long covid and fasting causes big problems. It didn't before but something in the immune system gets messed up with long covid and fasting makes it worse. Be careful and listen to your body.
Interesting! I have been giving my husband NAC for several months now as it was recommended by Stephen Buhner in his protocol for Lyme Co Infections. Specifically for Mycoplasmas in the Red Blood cells that we reckon was causing my husbands Anaemia of Chronic disease. He was diagnosed with RA nearly seven years ago and is in remission following the Antibiotic Protocol and Buhners recommendations. So Buhner recommends NAC, Bidens Pilosa, Sida Acuta. Also Cryptolepsis for Haemoplasmas and Mycoplasmas that are intracellularly sequestered in the red blood cells. His Blood work is gradually improving. Also takes Lactoferrin. So good to see another Kiwi taking the alternate route. And good to see the research to back it up. We had little to go by but have succeeded in reversing his health issues. He was also taking Curcumin but I found it interferes with Iron absorption. So he takes it away from Iron. He is 76. And so we shall look at the additional suggestions and keep him well. Always appreciate new information. The Drs had no suggestions for his treatment of the Anaemia of Chronic disease except steroids!!!
Ingredients of protandim. A patented blend of turmeric, green tea, bacon, milk thistle and ashwagandha. The exact tiny amounts contained in each tablet have been studied by independent universities funded by them and also by the government.
I know people with RA that are almost symtom free after taking 4 tespoones of Moringa power per day. There are some scientific studies on Moringa/RA, showing it's anti inflammatory effect, too. There are studies showing that Moringa reduces anemia and increase hB levels as well. Make your own research and talk to your MD/Practitioner before trying it, though! Sorry about my bad "tourist-english" - not my first language... 😊 Hope you can understand it anyway... 😊
OMG - what have I come across - this has relieved me of symptoms from the covid vaccine giving me so many problems. This has with so few tablets removed the vaccines effect on me - it's the only thing I have had left to try and very happy to share my experience if wanted. It worked for me and I feel very close to my old self - see if I get even better over next few weeks. Thankyou so much for posting as doctors around here have no idea. I also used Tumeric 2000mg per day for 2 weeks to thin my blood and this helped my heart as I suspected miocarditis before the media came out with this. Turmeric- fantastic too.
Thanks for this critical information. Your notes regarding Liposomal Glutathione are important. Glutathione is not the only healthgivity supplement using the liposomal delivery process, including others that may cross the blood-brain barrier unchecked. I do believe people "overdose" on too many overlapping anti-oxidants causing reductive stress, leading to potential cancer issues? A future discussion.
I do take in the morning 1,5gr of L-Serin with 1,5gr NAC. Before going to Bed, I take 6gr Glycine with 1,5gr NAC. At 2pm I take 20gr Collagen with 5gr Creatine and 700mg Hyaluronic Acid and a pinch of Vitamin C. I am 53 Years old and very Athletic and Bodyfat around 12%. I do take some more Supplements. Thanks as always Dr Brad.
@@JosePerez-pn3ke It is hard to judge for me because I have been a very fit Person nearly all of my Life. I did start to take supplements around two years ago and with L-Serin, Glycine and NAC, I started four months ago. I do feel great but I do many things besides as well. If you are interested I will write it down for you. I think it helps, especially for a person which is not so active and fit all his life. Everybody gots their Bioindividuality to be aware of and important also are sports, sleep, circadian Rhythms, positive life and food restrictions. We always point with one finger to something but we got ten of them. I mean we focus on one thing but it is many more factors. I never had any side effects taking L-Serine, Glycine and NAC. Just try it out for at least three months.
Taking it as a younger person who has struggled with sports injuries, inflammation, allergies, and sinusitis has seemingly been a game changer- the only bad thing has seemingly been the awful smell of the supplement itself, so if you’re new to it I’d advise taking it with a small snack of some sort, not on an empty stomach completely.
The whole principle of allowing the balance of the body to maintain itself by feeding it precursors is quite thought-provoking when focusing on other ailments.
You can just do Wim Hoff method with the same effect to turn on balancing of oxidative stuff. Breathing is oxidative enough and we know that running makes your body to solve oxidative stress much better.
It would be interesting to see this done in younger individuals who have prediabetes/ diabetes. I am a podiatry resident in the US. Many of our patients suffer from uncontrolled diabetes. It seems there are little negative consequences with this and is affordable.
I'm a type 1 diabetic of 35 years now. Tempted to try glycine but I'm reading conflicting information that it may actually cause a release of glucagon. Think I'm going to order a bottle and try small doses and see if it affects BS #s, since the upside if it is indeed as beneficial as I'm hearing seems worth it. And if it does increase BS then I'll just have to not take it.
@@thecandyman9308 Hi , my son is 36 and he is Type1 too. Did NAC help you with regulating Blood sugar? Any other supplements you might recommend ? Many thanks in advance!
Could sombody please address the study’s that point to NAC supercharging cancer growth. I love the idea of taking NAC and I have taken it but it only takes a google search to see the cancer studies
that was from a study which used huge amounts of NAC, equivalent to about 15-20grams of NAC for 60-70kg weight person. Clearly such overdose will do harm, almost all substances would do taken in such extreme excess. You must carefully read the parameters of studies because media and pharma manipulate with these.
There are also studies that concluded NAC actually shortens lifespan. NOVOS Labs advise against taking it. There never seems to be consensus on anything.
@@santanacaipirinha9536I'm not saying you should or shouldn't take anything, but we live in a world of deliberate misinformation for profit. In other words, the more effective a drug is at prolonging your life or at treating an illness not provided by pharma, the more likely there will be conflicting information on it. Same way ivermectin was ridiculed for COVID and fenben for cancer
Excellent concise clarity, thanks for this explanation, I'll watch it again. I'm 70 yo, 79 Kgs. I've been taking 1 gm of NAC daily and it has worked wonders, recently added 3 gms of Lycine but I haven't been taking them together. I have to say my gait has probably doubleld - I'm back to the fast walk I had up till around 45 yo which is interesting. I'll increase NAC to 2 gm and take it with Lycine twice a day. TBH I've held back because the amount of improvement and its speed was a little too much !
Hi Dr Brad per your previous recommendation I have been using NAC and L-Serine - I am 70 and have found this combination greatly effective physically but also surprisingly restored memory functions is using l serine still your recommendation? Thank you
Hi Bob, it's still a toss up for me between glycine and L-serine. L-Serine gets converted to glycine, and this study looked specifically at glycine with respect to aging. So at this stage I'm going to switch to glycine, but it really is a coin toss
I used NAC when I had covid and the results were amazing. I thought it would help me to take the capsules intermittently thereafter, as I have lupus following chemotherapy. However, it gives me awful heartburn and gastritis. Which I can't afford to have as it was a gastric lymphoma that resulted in chemo. I'm tiny, so a small dose has beneficial effects, but even with milk or yoghurt, I get the burning pain. Also, check the medical data: NAC interrupts normal programmed cell death/apoptosis, so perhaps should not be taken continuously
I turned 45 this year and started taking 1.6 g NAC plus several grams of glycin daily. I use glycin simply as a sweetener for different beverages and foods, because I'm on a low carb diet. I haven't checked my glutathione levels yet though.
Doc, yet another excellent video. This augmented my knowledge of supplements and will help me in the future. I do have a question about your omission of alanine. I read the study you referenced and it said this “Glycine and N-acetylcysteine and alanine were purchased commercially, and quality verified via certificates of analyses. These supplements are filled into capsules by a pharmacist, and provided monthly to study participants at doses of 100 mg/kg/d each of glycine and NAC, and 200 mg/kg/d of alanine.” Is alanine important? I’m assuming not because you did not bring it up but I just wanted to clarify it. Thank you very much and continue your great work
@@serbulentozturk8610 I will try to review the video again, and assuming that is the case, you did great by catching it. Thank you for replying and offering me this info. Have a great day.
It's continually strange to hear what I guess is the Aussie pronunciation "knack." In the U.S. we spell it out and say "En Ay See." Just throws me every time 😝 NAC is usually safe in lower doses, but if you have even slightly impaired sulfur pathways, here's what can happen: the cysteine "backfires" into the bloodstream, it damages the hemoglobin, and you feel like your lungs are filled with thousands of sharp needles. The hemoglobin regenerates every 90-120 days, and when you reach a "critical mass" point during that window, the majority of the symptoms will usually resolve, the rest lingering and tapering off over the next few weeks. But it makes for an extremely unpleasant 3-4 months. What impairs the sulfur pathways and makes one susceptible to this phenomenon? Mercury, for one thing, perhaps other heavy metals and certain industrial toxins, which binds to cytochrome enzymes and disables them, impairing those sulfur pathways. Don't ask me how I know this, and I know a few other mercury-poisoned people to whom it also happened. No such issues with glutathione IVs in my experience and as far as I know. But if you suspect you are mercury sensitive or are known to have genetic polymorphism of cytochrome systems, you should probably proceed with caution. I currently take about 600mg every couple of days, alternating with alpha-lipoic acid. When the "backfire" occurred (it was about 20 years ago by now) I was fresh from having had my mercury amalgams removed (whereby all long-standing pollen/dust/dander/grass etc. allergies simply disappeared), and I was taking 4 to 6 grams a day (along with vit C and E which help "recycle" glutathione, and milk thistle) to try to boost my GSH. I had a follow up with the dentist at that time, and the novacaine wasn't working - he had to pump in like 4-5x the normal amount to get it to act. The NAC-fueled detox systems were just eating it alive! So a little can go a long way, and safe is always better than sorry! GL to all.
@@stephanieilluzzi7355 You're welcome. My experiences are decidedly outside the norm as a person who had metabolic damage from chemical exposure and mercury, but it very conceivably could happen even at moderately high doses to people who are more susceptible because of genetic expression of CP450, or have sulfur sensitivities etc. in general. So caution and "starting low, ramping slow" is always the best policy, IMHO. All the best
I'm 56 and DID NOT take anything you said as medical advice. That being said, it was highly useful to hear the dosages you'd take at me age. Thank you.
I take NAC and TMG once a day. I am 71. I may start taking it twice a day as I have noticed a general well being, and less inflammation (from arthritis, though I do take a handful of other supplements and vitamins, all considered safe -- no MNM, nor resveritrol or NR). NAC and Glycine are both considered generally safe supplements. I appreciate this video and information!
Been using Nac and L Glutathione since, my failed TKR in 2017 that, brought on severe Arthrofibrosis and Complex Regional Pain Syndrome. I don't use opiates I researched and found out that these two supplements help with my Central Nervous System that is constantly over firing nerve damage. Im not cured but, I can say they helped with my symptoms of atrophy and chronic pain.
Very much appreciate that you show the results of the studies in numbers and explain them. That is much more valid than generalized claims "xy" helps wit "z".
Hey, Sir hope you're doing fine, I just wanted to clarify that There Is a study Showing NAC Suplimentation Does Increases The Risk Of " Adenocarcinoma Of Lungs on A Mice Stuy". JCI Insight 2019 Published On October 3rd In NIH Hope that you can Also make a video about Supliment Including " NAC+ TAURINE".
Question for Dr. Brad (or anyone) please. In Medcram video #70, 10 seconds before the 3 minute mark, Dr. Seheult shows graphically a glutathione molecule, which is composed of 3 amino acids: 1) glutamate, 2) cysteine and 3) glycine. According to the the Medcram video, NAC is composed of cysteine and glycine. So my question is why supplement with glycine if you are taking NAC, since the NAC molecule is already composed partly of glycine? In the Medcram video, NAC alone (without supplemental glycine) was believed to raise glutathione. Thanks.
Thank you for the valuable video AND for sharing what dosage you would use. I’m 53 and a great fan of bio hacking. I healed myself with nutrition and targeted minerals (based on a HTMA with regular retests), which turned my health around completely. However, I was diagnosed with melanoma in situ. While all is well now, it made me look for an approach to heal my mitochondria, as studies have proven that the diseased mitochondria is the first step in the cancer process, not the cell itself. I found a bulk powder form of both glycine and NAC and will give it a whirl. Thank you 🙏
@@thecandyman9308 So far so good. Two more biopsies - both negative! I also recently went to a mitochondrial and metabolic specialist and ordered a Genova test to check 150 biomarkers. I'll be reviewing the results on 11/17.
Interesting to learn about the cellulary mechanism and imbalance. However, what also increases the glutathione production in our body is the exercise itself. Supply all the amino acids in a balanced diet and exercise. No extra supplements needed. You are welcome.
@@alexanderohanlon8825 drug companies would never want to admit this...who wants to stop a regular revenue stream. We have to be proactive on our health...it is our right and responsibility
After watching the video and reading through the comments, I wonder if this would also help with skin elasticity. As you age you lose collagen production AND your skin becomes thinner. I'd love to see if this would make a difference there as well. I know L-lysine (essential amino acid) plays an important role in the formation of collagen.
There could be. Interestingly redheads can synthesise amino acids like glutathione better, there was a recent study that showed redheads look younger on average of 2-3 years.. they didn’t mention the reasons behind this being NAC but it’s good for thought
It is well known in the bodybuilding and powerlifting community that NAC is effective in protecting your liver while on gear. Look into TUDCA as well. A thousand times better than milk thistle.
Hey Dr Brad, great video but I wanted to comment. Not everyone should use creatine (generalization). Especially those with kidney damage. That can send you into kidney failure quite quick if your body can't clear creatinine. Thank you again for the video.
Get checked out hot shot, been using Nac and vit c combo nearly a decade (fight colds,hangovers,covid) works wonderful everytime also am 220 jacked weight lift zero nose bleeds, SEE A DOCTOR could be a brain tumor.
Your 3g per day post-55 still seems quite a lot as most NAC supplement suppliers recommend a dosage of 600mg-1200mg per day. Do you think that lower amount could still work, together with good diet & exercise? And does the body build up stores of glutathione such that taking GlyNac for a longer period than 16 weeks could result in higher levels of glutathione in the body?
Fact to know: NAC turns off the gene NRF2 which, when activated, turns on over 500 cellular detox pathways. I usually rec my patients rotate between NAC/Glycine and supplements/foods that upregulate NRF2 (such as curcumin and broccoli sprouts/sulphorophane)
@scrow7752 the body is always changing :) its good to take breaks/rotations. Look into superoxide dismutase (SOD) - another really good one to throw into the rotation. Or butyrate
Ah, you beat me to this video. I've been following the study protocol for just over two weeks, and all I can say is "WOW". Since about six days into the regimen, my energy levels have skyrocketed. I used to lament being tired all the time, needing to take nap(s) every day, yet never feeling rested. Moreover, my mood suffered as a result. Additionally, my physical capacity for exercise has eclipsed what I was able to do before, especially in grappling and bike riding in high-heat conditions, two activities that used to kick my ass. So, I'm continuing this with great expectations. I will do blood tests after another two months, but obviously cannot access the detail level testing the study participants describe. I won't be surprised if further studies along the line of this researcher are somehow buried or otherwise quashed with new appeals to the FDA to restrict sales of NAC, which worries me greatly. Never under estimate the power of pharmaceutical agencies. However selective the criteria were, it is understandable they were done that way. Just imagine the cost of running such a study with the extensive testing and detailed tracking of so many parameters. Had they opened up the parameters too greatly, the number of weaknesses pointed out due to lack of standardization would increase greatly. Naturally, the study authors themselves are excited and have repeatedly asked to increase the number of studies and diversity of studied cohorts. The lead researcher may well deserve the Nobel Prize.
@@TheReminderChannnel yes, 100 mg/kg, and I'm 59. I look forward to doing some extensive blood tests in 2 months, but in the meantime my productivity has skyrocketed more than I thought it was possible. I'm not exaggerating when I say this has changed my life, and I don't know if it's just the supplement and power of suggestion, however I've taken so many supplements and spent literally thousands of dollars a year on top level supplements for many years and never noticed such a result. If this is indeed some sort of placebo effect well, as I always say, if the placebo works it's no longer a placebo. PS: unlike a lot of supplements these go down easy and don't cause upset stomach, yet because of the number of capsules I do split them in three doses throughout the day for sheer convenience.
@@worldsokayestmedic4568 wow! I’m so happy for you! This is amazing! Are you taking them with food or on an empty stomach? Are you taking any other supplements too? Thank you again 🙏
@@TheReminderChannnel these go down really easily. Both my wife, who is very sensitive to supplements, and I can take these on an empty stomach without feeling any queasiness or anything else.
I do 1.5g of NAC 1.5g Glycine in the morning & before bed, always on an empty stomach. Don't forget 100mg of P5P on empty stomach 3 times while awake (B6, 33.5mg 3 times) for amino acid metabolism.
I am 75 and I took NAC, GLY, NMN, Resveratrol etc for three months. I lost weight and height. My hair turned black. Now my friends think that I should join a preschool.
@@texastexas4541 Have you watched his video on resveratrol? The positive results of resveratrol were found to be a lab error and couldn't be replicated: ua-cam.com/video/JAFnD27ffqE/v-deo.html
Yeah.... careful with the glycine though. It will cause an iron deficiency in a very short time. Not sure why, but glycine eats up free iron like there is no tomorrow. Restless Leg Syndrome is a dead giveaway that you need more iron. Cramps are a hint that you are getting too much iron. Be careful and stay aware. It's not as simple as "just take glycine". There are side-effects that need to be handled properly. Good luck!
I love the channel, it's very interesting. I have a question, I am a 32-year-old girl, and I am worried about the large amount of gray hair that I have. Apparently it's something hereditary, but I don't think I can't do anything. I know that glutathione decreases after 45, but in another channel they explained that it is possible to have a genetic alteration that decreases levels or training, can that be true? I should go ahead and take it, is it possible to overdose? I don't know whether to check my blood levels, but I don't think it's very easy to ask my doctor, and I don't know if it's necessary. Yes, they have requested an analysis with "sex" and thyroid hormones and iron. And I take vitamin D, which used to be deficient, although I am also worried about an overdose. Thank you for the information you are sharing!.
Hello Dr Brad, I see Glycine comes in both powdered and capsule forms. Which do you recommend? Also your supplement list for the ones you will take later on in life you doesn't give a brand recommendation. For those of us already in that age bracket we would love to see that. Thanks so much for the great work.
@@richardprice9730 I never used it as a sweetener. Can it cause a sugar spike? My wife is a T2 diabetic. I ordered capsules just now for myself and will probably consider powder form after your comment. Cheers, Bob
Wow! Great results so far. I am also in my 70's and wonder if my Glycine and NAC powders could be combined in distilled water that i sip throughout the day? Would I get unwanted chemical mixture that undermins my intent?
Yes a really important unaddressed question is what the minimum dosage is to get the same increase in glutathione. No data so far it seems. Could such high doses cause kidney damage?
Hi Dr Stanfield, thanks for your videos, they're very informative and easy to follow! I'm wondering if you could do a video about the study done in mice that shows NAC promoted tumor growth? I'm currently on NAC for biofilm treatment - this supplement has had other unexpected benefits on my muscles and energy [I have SMA Type 2]. Would really appreciate your analysis of that study. Thank you!
Rapamycin study donation link: bit.ly/3QwugRx
Join me over on Twitter: twitter.com/BradStanfieldMD
Patreon: www.patreon.com/bradstanfieldmd
www.donotage.org/products | Use code CheckWithYourDrFirst for 10% off
This reminds me of when you said you wouldn’t take curcumin. Apparently, curcumin helps the body to maintain it’s natural glutathione production as opposed to many other antioxidants which caused the body to down regulate production of glutathione and super oxide dismutase. I’ve seen that study in several videos by others so I was confused when you said you thought there was no point in taking it.
There is loads of glycine in foods, so why supplement?
Hi Dr Stanfield. Do you have anything to combat gray hair? Mine occasionally reverse themselves (have hairs that are gray at the end and black at the bottom) but I'd love to know if there's something i could do to influence it
@@garthb4131 He’s only 29.
@@thev3432 Right, so he doesn't need it yet. But i was just wondering if there were any supplements that have been shown to help. Someone below seems to think the NAC is helping reverse their graying
My Doctor is a Professor of Neuroscience at a large University in America. He was impressed with this study, I suffer Long Covid from Delta last October. He put me on 1,800MG of NAC in split doses daily, and 3000-4000MG of Glycine to be taken with the NAC same time. Alot of my Back, Joint, Muscle pain is gone now. The Glycine he said at 3000-8000MG really calms the Brain, he was right, I can feel the calmness. Dr Stanfield Thank You for your tireless efforts to find ways to help the sick get well and the well stay well.
That sounds great. How fast did you feel the improvements? Long covid is terrible.
I would add ALA to that mix ?
CALEB, LIAR
how long have you being lingering with long covid?
@@leelunk8235 liar ?
Been taking NAC for 6 months.
I was 50 years old but since starting NAC I've lost years, feeling and looking younger.
Unfortunately I'm now 8 years old and can no longer drive....thanks🤷🏼♂️
😂
I’m 78 years old, female and tried the liposomal glutathione which you mention was not really the right product. I would like very very much to get your recommendations for the brand of NAC and glycine.
@@sheilasteele5887 i take one from "NOW" and i think it works well
lower your dosage or you may unborn yourself
I bet you're a Wiz at climbing trees though.
I was taking NAC and Glycine for 3 months,now i am typing this from a womb
LMAO 😂😂
🤣😂im dyin....give me some....🤣😂
Oh, how’s the view? 😂
😂😂👌
I better look like a zygote then
I have been talking it since the pandemic started. I had horrible uncontrollable asthma and was taking super strong steroids. I started 1000 mg 3x a day NAC and in months I did not need an inhaler or steroids. I stopped Nac and each time I felt my lungs weaken and need inhaler. Now I'm back on it breathing beautifully by the grace of God
Is 3000mg the dose that only works for you? Have you tried lower doses? I have asthma also, I'm taking 700mg of NAC + 600mg of glycine. I've only been taking them for a week and have noticed improvement, I'm wondering if i should up my dosage?
@@INTJ82 I started taking 600 mg 3 times a day since I ran out ans have not been able to find the 1000 mg pills and I have noticed a HUGE decline in my lungs and breathing. So definitely the 1000mg 3 times a day was the sweet spot for me. It's day and night difference. There's probably maintenance at low dosage and healing at higher doses. I would definitely up the dose at least for 1 month and see how you do. I did not have any side effects except happiness from not having to struggle breathing all day. Let me know how it goes!!
Vitamin D3 50ng/ml blood level + cysteine 600 mg makes glutathione by glutamyl-cysteine ligase
I would suggest combining NAC with glutathione already since at your age you really have low glutathione in your body already which precursors like NAC maybe have a problem converting enough for you already
Eat raw organic garlic as well it got rid mine and it reduces the air wave inflammation and cleans and detox all your organs and arteries.
I had irregular heart beat and was put on 50mg Metoprolol per day. Even so, some days my pulse would still beat irregular. It was frightening actually. Forget how and why, but I started taking NAC 1000mg supplement only once a day. 2 months later I notice my pulse is always regular, so I reduced Metoprolol by half, and for 6 months my pulse never miss a beat. The dose recommend on the NAC bottle is 3 times what I take. Thinking now I will stop Metoprolol completely. Maybe my heart just comes good on its own or maybe the NAC... cant be sure. I am thinking the NAC reduce my blood pressure which in turn helps my heart beat. I am 72 and always worked hard as a Plumber and drank a lot of booze in the old days. Now a reformed drinker and smoker and have a healthy respect for God.
My heartbeat started becoming irregular after my second dose of the vaxx. Take that as you will.
@@trollking99 Interesting. Its possible I suppose as it was never fully tested and rushed onto the scene as it was. As a latter stage COPD victim of asbestos, my doctor never pressured me to get the vax as there was a chance the small amount of virus injected could make my case worse. So I never ever had it and never will. The weird part is, my sister and husband had all 5 vax doses, and he got Covid twice and she once. Go figure. I think the best way to avoid it is less contact with others = less chance to get it.
God is my all.
(Born in 51)
@@ByDesign333 Me too. Born in 50
@@trollking99 I also developed heart issues after my second vaccination. I started having inner vibrations as well and continue to deal with them daily. As I type this I’m wearing a heart monitor and hope to get answers soon.
I was active and very healthy before. Now my quality of life is 0 and I’m still fairly young.
Been on 600 mg. NAC and 500mg. Glycine daily at night for two weeks. Lost 10 pounds. WAKE up hungry. Double my energy and concentration. A home run as far as I am concerned. Maybe a new fountain of youth? You are what exactly the medical profession needs. Unbiased information for your patients. God Bless you 🙏
can you share which pills you are taking and where you ordered them from? thanks
@@peakflow1169 Life Extension - N-Acetyl-L-Cysteine 600 mg. / Source Naturals - Glycine 500 mg. I buy them from Swanson Vitamins.
Starting this stack today
@@gz625 🤣 why I’m not taking it everyday
@@douglascyr7627 Hi Douglas. I bought nsc from eBay. When I took 700 mg, 1 capsule, I feeling somewhat confused, just a bit and anxious...
What do you think, is it usual thing?
2) do you still having that NAC?
Speaking as a layperson, I'm amazed at the progress that researchers in aging have made in just the last few years.
Yes, but im also kind of confused at this point.. Would be great with a 2022 recap of what maybe works, and not
@@mortenvinther8940 Yes, an annual recap would be great
I agree, and I'm still in my 30's but due to some health problems have become invested in looking at the most recent research. I'm not necessarily looking for aging related assistance yet but having the information is useful.
I think it is so surreal
@@estefencosta1835 fasting is many more times effective
I started taking NAC during 2020. A doctor from Med Cram, Dr Sheult, pondered the health of taking NAC, so if you got covid, you could fight it. Along with vitamin D. I have been taking it ever since, I am 60. I have lost 35 pounds. With potty training my dog, walked a lot. Also started putting a squeezed lemon in my large water bottle. All the above caused me to lose that much weight. I am 60, post menopausal, on Hormone replacement therapy. Go figure, you can lose weight after MENOPAUSE.
How much do you take?
Nac was shown to cause cancer in mice. The mechanism is that nac prevents the death of cells due to ROS, however these cells that "should" have died go on to become cancerous. Get a checkup.
Hello Jean, I just added NAC to my supplements. I’m 63 and post menopausal also. Losing weight after menopause- you are an inspiration!
I was wondering what dosage of NAC you are taking? I started at 600 mg but wonder if that is enough. Thanks!
I lost 25 lbs at 63, low carb with intermittent fasting. It wasn’t even hard and I’m not on hormones. I think the difficulty of losing weight as you age is exaggerated.
Dear Jean: nac has reduced my pain level more than taking 1000mg of vicodin. I am in my second week of taking nac and am moving to the point of not needing pain medication. My wife is also taking nac. She is taking 1200mg daily. Her weight is 154 and hopefully she can soon reduce her pain medication. Just not yet. I half the time will double the dose of nac to 2400mg. Am also taking vitamin k2 + d and am removing atorvastatin as blood fats improve with the k2. Do not immediately take a double dose of k2 right away as I had a trip to the emergency room. Doubling up nac has no immediate effect. Don't do as I do in any case. Am below 200lbs for the first time in 30 years but not because of nac but because I am moving away from carbs to a keytonic diet. Am 75.
I’ve been taking a high dosage for over a year and I am in my 50s and I’ve noticed a big difference in my appearance, energy levels, and endurance
What dosage do you take? Is it nac only or nac plusnglycine?
Should a person take it at night or I’m guessing maybe it’s better to take it in the morning, does anyone know?
@@thirstonhowellthebird I've heard taking NAC at night is good cause antioxidants work well as you sleep.
Any suggestions on nac and glycine brands?
@@garybarrettapex Just get it from a brand you trust.. there is a lot of NAC out there..
After seeing your video I started taking 1 gram each of NAC and glycine 3x per day. It has caused a major improvement in my brain fog symptoms that I've been struggling with for years. THANK YOU!!!
Hi just checking, are you a real person or Bot ?
@@darren6831 real person
Try a gluten free diet, this may help!
look up Lumbrokinase. Could be very useful for brain fog.
Age? I'm 75 and trying to equate age with NAC/Glycine daily dosages. I had triple bypass surgery last October and am doing great . I've been taking 600mg NAC twice daily but not Glycine. After seeing this vid I'll add Glycine with the NAC. Cheers, Bob
Brad, super good news on research studies this week using NAC with results that were quite impressive. The studies will soon be Peer Reviewed and likely be reported in both Lancet and NEJM. Your video on NAC and Glycine is yet another big positive in the medical world this week. Keep up the good work Chap.
Results won’t translate to the general population. Did you even watch the video?
@@Krunch2020 mean response.
Don't forget the increase in heart attack and stroke…
@@JoelDubayis that actually a thing with taking this cocktail?
I took NAC when I had the delta strain covid about 10 months ago. It is a supplement on the “ Americas Front Line Drs. Protocol. 💐🙏🏽😍
My health care provider said, “take NAC 3 times per day. I’m 68.
is NAC and b3 are same?
nac 600mg three times a day?
@@wasimahmed1570 D3 and NAC are different. Please look it up on line. Dr. Eric Berg has good information.👍
@@1111111111202 yes 600mg 3times per day.👍
@@wasimahmed1570 No, b3 is Niacin. NAC is totally different. Look up NOW brand. Great stuff.
mmm, thanks for the understanding around why we shouldn't mess directly with glutathione regulation and instead focus on providing the building blocks. I had never thought of Reductive stress, but makes a lot of sense.
Thank you Dr. Stanfield for opting for a community funded research and therefore having that amazing freedom to be unbiased, and to not have to walk on eggs as it were, around what large biomedical companies dictated to be "the science". Scientific research needs to be unaffected by politics, and systems of regulation and funding which are poorly set up resulting in incentivizing managing the symptoms and not treating the molecular causes of conditions.
The work you do on proper informing of people on molecular biology and gerontology is commendable in itself, too.
Wishing you all the best, and to hit that mark for funding of your own research.
100%
@@philipmaxim7804 68.5%
Welp, I just turned 45 and have been taking NAC and have done several extended water fasts, my record has been 60 days straight. I will be adding Glycine until I hear otherwise, thanks very much!
Why would you want to fast for that long?
60 days? Are you training for Monkdom?
@@tgm2754 Lichdom
🤣🤣🤣🤢🤢
@@tgm2754 Lich-dom
I'm 47 and GlyNAC is life changing. I feel like a different person, and weirdly enough, I stopped snoring. It feels like my throat is more opened or something.
doubt it has anything to do with GlyNAC
NAC is a reducing agent that lowers the viscosity of mucus in the throat, It's widely used as a drug to release slimes in your nose and sinuses if you have a cold, flew or so. So what you feel makes perfect sense.
What dose of both are you taking?
I felt the same, it does help easier to breath
Dear Brad, I've watched a few of your videos now and really like the clear way you describe this science. Its obviously entirely science based and you consider all the evidence and admit when the science is not clear.
Can i just say that, perhaps because im older, i find your delivery a bit fast for me to readily take in all the information that you are imparting. I dont want to criticise because you are doing an incredible job and i've learnt so much. Just a suggestuon for you to consider.
PS i dont know if theres any research on this, but from watching a lot of young people, I feel that these days you are speaking faster. But this may just be that i am slowing down generally and its a relative thing. I dont know. 😊
Take care, all the best and as a fellow Kiwi, am very proud of your valuable contribution
Something that helps is to tap the settings icon on the upper right of the video. When the box pops up, tap "Playback Speed." Then you can pick the speed you want the video to play. You can speed it up or slow it down.
I use "Video Speed Controller" add-on in Firefox and Chrome. It works well for slowing down fast-talkers and is also great for speeding up slow videos.
Great research and maybe explains why in my experience a lot of health conditions emerged after I turned 55. After Dr Sam Baileys recommendations a while back I started taking NAC and feel a lot of positive benefits alongside a low carb diet I now feel a lot better at 63 than I did at 55.
Hi, can you please give me the dosage of glycin and Nac. I have ordered this 2 and vit C . Im 42 and starting to get wrinkles so i decided to give it a try! Anyone can give me dosage recommendation and how many times per day! Appreciate your answer!
@@Jharieltravel Hyaluronic acid internally and retin A topically also.
great combo for better health:)
I'm only 32 but have started supplementing with NAC and Gly and it's been the most positive experience from any supplement I've ever taken. It started day one! I also have chronic sinus pressure and issues that not even precipitation sprays would help and this combo has me breathing clearer than I can remember last. I'm sleeping through the entire night now too and I attribute that to better breathing.
Are the supplements prescribed?
@@cesarlopez8073 no
What dosages please?
We need more info as you can see by the comments. I also suffer from severe allergies and sinus issues. Dosage and other supported info would be helpful
Hi, can you please give me the dosage of glycin and Nac. I have ordered this 2 and vit C . Im 42 and starting to get wrinkles so i decided to give it a try! Anyone can give me dosage recommendation and how many times per day! Appreciate your answer!
very informative, short videos , straight to the point and no bs , finally a channel i can watch without skipping half of it , subscribed
Wow !
After reading the study, I found the reduction in Triglycerides to be over the top statistically. Even though this study excluded those with triglyceride problems, this is an improvement equal to or more than the statin market. No wonder the FDA wanted to make NAC illegal, so that it could be monitized.
🎯 Key Takeaways for quick navigation:
00:00 🧬 *Introduction to NAC and Glycine Study*
- Understanding the shift in thinking about oxidants and antioxidants.
- Oxidants as stress-induced survival signals.
- The role of glutathione in oxidative stress and aging.
01:51 🧪 *Glycine and NAC as Building Blocks for Glutathione*
- Glycine and NAC as building blocks for glutathione.
- How aging leads to glutathione deficiency and elevated oxidants.
- The potential of glycine and NAC supplements to restore glutathione levels.
03:00 📋 *Study Design and Participants*
- Overview of the study design, including duration and goals.
- Inclusion criteria for older adults in the study.
- Red flags regarding the study's exclusivity.
03:55 🧪 *Study Dosage and Primary Outcome*
- High dosage of glycine and NAC supplements.
- Primary outcome: Glutathione concentration in muscle.
- Comparison of glutathione levels before and after the 16-week study.
04:51 🏃 *Effects on Mitochondrial Function and Physical Function*
- Improvement in mitochondrial function due to supplements.
- Increased gait speed as a measure of physical function.
- Positive effects on aging-related physical decline.
06:00 ⚖️ *Balancing Oxidants and Antioxidants*
- The importance of maintaining a balance between oxidants and antioxidants.
- Concerns about direct glutathione supplementation.
- How glycine and NAC supplements avoid reductive stress.
06:56 🧪 *Study Limitations and Future Research*
- Acknowledging the limitations of the study, including its size and criteria.
- The need for longer-term, larger-scale studies.
- The potential for age-adjusted dosage of glycine and NAC supplements.
Made with HARPA AI
Thanks!
Thank you
Thank you
Thank you!
Im a chemist and was really sick with joint pain, headaches infections and anxiety for 4 years… Long term fasts / nac / garlic / kefir and curcumin were the strongest things that helped me. Another thing was removing caffeine and dairy consumption. Nowadays Im quite healthy. 🙈 Just add garlic often and take some nac once in a while.
what was causing all of that in the first place?
@@supernice_auto most likely autoimmune issues (i have same)I do some of what this chick does/did and they work especially Long fasts (i.e. 4-5 days per month, or couple days biweekly) NAC also really good, Glycine probably good (especially for mood, in my case anyway) and garlic/unions are also good. BTW curcumin is the most overrated supplement out there, together with Chia seeds. In my case they were both bad (not horrible, but bad) and I'm sure they are not any good for anyone, but people use other supplements with them and think that benefits they are getting are coming from those two (Both Chia seeds and Curcumin were inflammation inducing for me, which exactly what you do not need lol). Flax seeds are really good and have anti-inflammatory and anti-cancer properties as long as you use them with yogurt or A2 milk, not the garbage milk from grocery stores.
@@otherone1234 I appreciate the insight sir- I've been looking into NAC as well but have not yet committed to actually trying it
@@supernice_auto it was autoimmune stuff due to bad sleep, jaw clenching because of my breathing issues ( broken nose years ago) and gluten causing inflammation ( nasal turbinates were swollen too ) not breathing and thick mucus caused so many issues which NAC is great for, I had headaches after each meal. One year after this comment Im even better. Lowered gluten, still take nac not daily but few times a week. And I take vitamin b, magnesium and fast every few months for few days. I feel great.
thanks for the reply here- i'm glad you're doing much better!@@thegalhorowitz
If you take protein powder and collagen daily be sure to check the ingredients. I ordered a bunch of Glycine and NAC pills only to find out the protein powder and Collagen I take contain a combined 3,500mgs of glycine.
Beyond ensuring that we have a balanced healthy diet, I wonder if obsessing about the next wonder supplement wastes more precious life than we might gain. Supplement manufacturers and UA-cam bloggers probably have much more to gain from this than we do.
You are doing great work with this channel.
As a 57 year old, I'll be upping my 1200mg of NAC a day to 3000mg and adding 3000mg daily of Glycine. Thank you Dr!
Now here’s a BS comment (AI)., to top them all
@@Yet333huh?
Glycine and glutamine in a 2:1 ratio help the body to creat glutathione in the cells. Taking it orally or through iv is bad because glutathione also mobilises mercury into cells when taken orally, making a person sicker over time.
I take this everyday , among other supplements and been on clean keto and IF Im down 80 lbs since last oct of 2021 and I feel so good I sleep so good and I'm just so healthy it's crazy
Congratulations! Was there something about this combination of supplements that enabled you to do IF and keto and lose the weight? More energy? Feeling of well being, stress resistance?
Dr Stanfield - great video and thank you for the summary of the research. In my opinion, as a researcher myself, I prefer the exclusion criteria they applied. They excluded individuals with health risks that could skew or interfere with understanding the impact of the substance on an aged adult with a "normal" metabolism. So in fact, I do think it is applicable to the general aged population. As a Dr., you are probably more focused on individuals who are ill or in a diseased state, and I respect that perspective. But first things first, lets find out what it does without the disease state.
NAC just wrecks my stomach.
Maybe NAC fuels cancer too? It could be, right? We do not know in fact and we do not know what NAC does in ill people, illness which have the most of people in der midages. Would you share my perpective?
I have intuitively taken NAC and glycine (as a sweetener for tea) for over a year now. I'm still young but, as a scientist myself, I see the potential of these two supplements.
Great video!
What form of glycine do you take?? Is the glycine in magnesium glycinate effective?
Is it the glycine that works as a sweetener (say, in tea). or the NAC … ?
@@33333Tarun é um segredo... ela não tem empatia e nunca irá dizer.
@@snowyowl6892glycine
@@33333Tarunl-glycine, mag glycinate probably doesn’t contain enough
Great video Brad! I was already taking NAC and now I’m going to add the Glycine. It’s always great to add supplements to my stack that are actually CHEAP! Win win! 😊
One of the few things that detoxes glyphosate aka round up
whats your experience with it
@@AldousHuxley7 NAC, glycine or both together? Which detoxes glyphosate? Thanks
@@johnlibonati7807 Both taken seperately. Also humic/fulvic acid.
@@AldousHuxley7 thanks!
For me it just shows we need more amino's as we grow older. Not just for glutathione, but also to keep muscle mass.
Creatine is one of the best supplements we can take for life to improve muscle mass maintenance, specially when we get older!!! ❤
@@juniaprocopio
Is Creatine a powder (or capsules) and does it occur in any particular foods?
Presume it is generally safe…
I am elderly…
@@snowyowl6892 It generally comes in a large container with a scoop. The common recommendation is one scoop, about 5 grams per day. It dissolves pretty well and doesn't have much taste.
IMPORTANT NOTE the most effective way to clear oxidative stress and have a cellular cleanse is from prolonged fasting.. that’s the first line of attack we should ALWAYS take before taking anything
Fastibg results will be more optimal if one enters that state with a high level of glutathione. And high B vits and mineral status. Am of the opinion that chronic vegans probably should not fast as they are likely too depleted already Have seem them try and have terrible outcomes.
I have long covid and fasting causes big problems. It didn't before but something in the immune system gets messed up with long covid and fasting makes it worse. Be careful and listen to your body.
Prolonged fasting is more pseudoscience crap pushed by wackadoos.
Interesting! I have been giving my husband NAC for several months now as it was recommended by Stephen Buhner in his protocol for Lyme Co Infections. Specifically for Mycoplasmas in the Red Blood cells that we reckon was causing my husbands Anaemia of Chronic disease. He was diagnosed with RA nearly seven years ago and is in remission following the Antibiotic Protocol and Buhners recommendations. So Buhner recommends NAC, Bidens Pilosa, Sida Acuta. Also Cryptolepsis for Haemoplasmas and Mycoplasmas that are intracellularly sequestered in the red blood cells. His Blood work is gradually improving. Also takes Lactoferrin. So good to see another Kiwi taking the alternate route. And good to see the research to back it up. We had little to go by but have succeeded in reversing his health issues. He was also taking Curcumin but I found it interferes with Iron absorption. So he takes it away from Iron. He is 76. And so we shall look at the additional suggestions and keep him well. Always appreciate new information. The Drs had no suggestions for his treatment of the Anaemia of Chronic disease except steroids!!!
Ingredients of protandim. A patented blend of turmeric, green tea, bacon, milk thistle and ashwagandha. The exact tiny amounts contained in each tablet have been studied by independent universities funded by them and also by the government.
O
What effect goes NAC have in RBC or hemoglobin if any?
I know people with RA that are almost symtom free after taking 4 tespoones of Moringa power per day.
There are some scientific studies on Moringa/RA, showing it's anti inflammatory effect, too.
There are studies showing that Moringa reduces anemia and increase hB levels as well.
Make your own research and talk to your MD/Practitioner before trying it, though!
Sorry about my bad "tourist-english" - not my first language... 😊 Hope you can understand it anyway... 😊
Chlorophyll for anemia
OMG - what have I come across - this has relieved me of symptoms from the covid vaccine giving me so many problems. This has with so few tablets removed the vaccines effect on me - it's the only thing I have had left to try and very happy to share my experience if wanted. It worked for me and I feel very close to my old self - see if I get even better over next few weeks. Thankyou so much for posting as doctors around here have no idea. I also used Tumeric 2000mg per day for 2 weeks to thin my blood and this helped my heart as I suspected miocarditis before the media came out with this. Turmeric- fantastic too.
Thanks for this critical information. Your notes regarding Liposomal Glutathione are important. Glutathione is not the only healthgivity supplement using the liposomal delivery process, including others that may cross the blood-brain barrier unchecked. I do believe people "overdose" on too many overlapping anti-oxidants causing reductive stress, leading to potential cancer issues? A future discussion.
FFS, first they say cancer is caused by oxidative stress but now it's something else.
What’s too many?
Whatever I've deduced is pretty correct
I do take in the morning 1,5gr of L-Serin with 1,5gr NAC. Before going to Bed, I take 6gr Glycine with 1,5gr NAC. At 2pm I take 20gr Collagen with 5gr Creatine and 700mg Hyaluronic Acid and a pinch of Vitamin C. I am 53 Years old and very Athletic and Bodyfat around 12%. I do take some more Supplements. Thanks as always Dr Brad.
Thanks for sharing! Can you really feel the difference using the L-Serin, Glycine, and NAC??
@@JosePerez-pn3ke It is hard to judge for me because I have been a very fit Person nearly all of my Life. I did start to take supplements around two years ago and with L-Serin, Glycine and NAC, I started four months ago. I do feel great but I do many things besides as well. If you are interested I will write it down for you. I think it helps, especially for a person which is not so active and fit all his life. Everybody gots their Bioindividuality to be aware of and important also are sports, sleep, circadian Rhythms, positive life and food restrictions. We always point with one finger to something but we got ten of them. I mean we focus on one thing but it is many more factors. I never had any side effects taking L-Serine, Glycine and NAC. Just try it out for at least three months.
Thank you, took lipsomal glutathione with NAC. Will stop (thankfully only took for a short time, hope it has not done too much damage!).
@ParanoidBishop Can I take liposomal glutathione and liposomal vitamin c with NAC&GLYCINE
Hi Doctor Brad, do you recommend younger adults (say 35-45) take NAC/glycine?
65yo: plasma Glutathione (no supplements) 04/2022: 238ug/mL
07/2023:started supplementing with 1g NAC + 1g glycine BID
09/2023: 271ug/mL
Labcorp range ug/mL 176-323.
Ya?? So?!
Taking it as a younger person who has struggled with sports injuries, inflammation, allergies, and sinusitis has seemingly been a game changer- the only bad thing has seemingly been the awful smell of the supplement itself, so if you’re new to it I’d advise taking it with a small snack of some sort, not on an empty stomach completely.
Just started taking myself and I hve the same issues as you- really hope it helps me!
What is your dosage, may I ask?
What smell?
Chemical smell and is sour like lemon juice
Smell? Never noticed that in NAC.
The whole principle of allowing the balance of the body to maintain itself by feeding it precursors is quite thought-provoking when focusing on other ailments.
You can just do Wim Hoff method with the same effect to turn on balancing of oxidative stuff. Breathing is oxidative enough and we know that running makes your body to solve oxidative stress much better.
'Age related abnormalities' ....brilliant!
It would be interesting to see this done in younger individuals who have prediabetes/ diabetes. I am a podiatry resident in the US. Many of our patients suffer from uncontrolled diabetes. It seems there are little negative consequences with this and is affordable.
You should look into berberine
I'm a type 1 diabetic of 35 years now. Tempted to try glycine but I'm reading conflicting information that it may actually cause a release of glucagon. Think I'm going to order a bottle and try small doses and see if it affects BS #s, since the upside if it is indeed as beneficial as I'm hearing seems worth it. And if it does increase BS then I'll just have to not take it.
@@thecandyman9308please keep updating your experience. Thx
@@thecandyman9308Any updates on how the low doses are going?
@@thecandyman9308
Hi , my son is 36 and he is Type1 too.
Did NAC help you with regulating Blood sugar? Any other supplements you might recommend ?
Many thanks in advance!
Who the hell would want to live longer? The way things are going that seems more akin to a punishment
My idea 😂😂😂
Started drinking again to avoid adding more years.
Woah maybe thats why japanese culture is full of heavy drinking haha. They are known for living very long.
Don't be scared
Life is hard, harder when you’re stupid!😂😂😂😂
You won’t necessarily live longer, but your quality of life will be better while you are alive.
Could sombody please address the study’s that point to NAC supercharging cancer growth. I love the idea of taking NAC and I have taken it but it only takes a google search to see the cancer studies
that was from a study which used huge amounts of NAC, equivalent to about 15-20grams of NAC for 60-70kg weight person. Clearly such overdose will do harm, almost all substances would do taken in such extreme excess. You must carefully read the parameters of studies because media and pharma manipulate with these.
Thank you
There are also studies that concluded NAC actually shortens lifespan. NOVOS Labs advise against taking it. There never seems to be consensus on anything.
@@santanacaipirinha9536I'm not saying you should or shouldn't take anything, but we live in a world of deliberate misinformation for profit. In other words, the more effective a drug is at prolonging your life or at treating an illness not provided by pharma, the more likely there will be conflicting information on it. Same way ivermectin was ridiculed for COVID and fenben for cancer
Excellent concise clarity, thanks for this explanation, I'll watch it again. I'm 70 yo, 79 Kgs. I've been taking 1 gm of NAC daily and it has worked wonders, recently added 3 gms of Lycine but I haven't been taking them together. I have to say my gait has probably doubleld - I'm back to the fast walk I had up till around 45 yo which is interesting. I'll increase NAC to 2 gm and take it with Lycine twice a day. TBH I've held back because the amount of improvement and its speed was a little too much !
This video raised my level of understanding about the role of oxidative stress.
I took NAC after a covid infection and my cough and reactive asthma cleared up faster than inhalers.
that's why they tried to ban it.
Thx for the upload!
Can you make a video about seed oil in the future?
Hi Dr Brad per your previous recommendation I have been using NAC and L-Serine - I am 70 and have found this combination greatly effective physically but also surprisingly restored memory functions is using l serine still your recommendation? Thank you
Hi Bob, it's still a toss up for me between glycine and L-serine. L-Serine gets converted to glycine, and this study looked specifically at glycine with respect to aging. So at this stage I'm going to switch to glycine, but it really is a coin toss
@@DrBradStanfield Thank you for your response. Is there harm to taking both L-Serine and glycine with NAD?
@@DrBradStanfield also interested in Serine over Glycine given Folate processing. Do you prefer L-Serine or Phosphatidyl Serine?
what is your dosage? thanks
@@bobcrandall2776 might be preferable a bit of both I suspect given one carbon (folate) cycle so the body can regulate it properly.
I used NAC when I had covid and the results were amazing. I thought it would help me to take the capsules intermittently thereafter, as I have lupus following chemotherapy. However, it gives me awful heartburn and gastritis. Which I can't afford to have as it was a gastric lymphoma that resulted in chemo. I'm tiny, so a small dose has beneficial effects, but even with milk or yoghurt, I get the burning pain.
Also, check the medical data: NAC interrupts normal programmed cell death/apoptosis, so perhaps should not be taken continuously
NAC in capsule form caused heartburn for me. I now take the loose powder mixed with water, no problems.
@@philhoges5141 I'll try that, thank you very much 😊
If if stops apoptosis, than it definitely can't be good to take regularly; so I wonder what would be a good cycling schedule
@@philhoges5141
I wonder why the capsules themselves would cause an issue? What is the "flavor/taste" of the NAC in water?
@@philhoges5141 hi which powder form do you take please and how much
Does this not give you hearrburm
I turned 45 this year and started taking 1.6 g NAC plus several grams of glycin daily. I use glycin simply as a sweetener for different beverages and foods, because I'm on a low carb diet. I haven't checked my glutathione levels yet though.
Hello!! Could you recommend the brandz you use please?
@@christophdenner8878 thanks pal, appreciate the reply.
I'm wondering if the heat of beverages would negate or lower the efficacy of glycine?
@@rhydyard That is a very intelligent question
@@rhydyard Glycin powder is sweet It is 1/3 as sweet as sugar. Add it into beverage to replace the sweet function of sugar.
Doc, yet another excellent video. This augmented my knowledge of supplements and will help me in the future. I do have a question about your omission of alanine. I read the study you referenced and it said this “Glycine and N-acetylcysteine and alanine were purchased commercially, and quality verified via certificates of analyses. These supplements are filled into capsules by a pharmacist, and provided monthly to study participants at doses of 100 mg/kg/d each of glycine and NAC, and 200 mg/kg/d of alanine.” Is alanine important? I’m assuming not because you did not bring it up but I just wanted to clarify it. Thank you very much and continue your great work
very important question. please answer
In the study be referenced, alanine is used as placebo for the control group so it is not part of the protocol.
@@serbulentozturk8610 I will try to review the video again, and assuming that is the case, you did great by catching it. Thank you for replying and offering me this info. Have a great day.
It's continually strange to hear what I guess is the Aussie pronunciation "knack." In the U.S. we spell it out and say "En Ay See." Just throws me every time 😝
NAC is usually safe in lower doses, but if you have even slightly impaired sulfur pathways, here's what can happen: the cysteine "backfires" into the bloodstream, it damages the hemoglobin, and you feel like your lungs are filled with thousands of sharp needles. The hemoglobin regenerates every 90-120 days, and when you reach a "critical mass" point during that window, the majority of the symptoms will usually resolve, the rest lingering and tapering off over the next few weeks. But it makes for an extremely unpleasant 3-4 months.
What impairs the sulfur pathways and makes one susceptible to this phenomenon? Mercury, for one thing, perhaps other heavy metals and certain industrial toxins, which binds to cytochrome enzymes and disables them, impairing those sulfur pathways.
Don't ask me how I know this, and I know a few other mercury-poisoned people to whom it also happened. No such issues with glutathione IVs in my experience and as far as I know. But if you suspect you are mercury sensitive or are known to have genetic polymorphism of cytochrome systems, you should probably proceed with caution.
I currently take about 600mg every couple of days, alternating with alpha-lipoic acid. When the "backfire" occurred (it was about 20 years ago by now) I was fresh from having had my mercury amalgams removed (whereby all long-standing pollen/dust/dander/grass etc. allergies simply disappeared), and I was taking 4 to 6 grams a day (along with vit C and E which help "recycle" glutathione, and milk thistle) to try to boost my GSH. I had a follow up with the dentist at that time, and the novacaine wasn't working - he had to pump in like 4-5x the normal amount to get it to act. The NAC-fueled detox systems were just eating it alive! So a little can go a long way, and safe is always better than sorry! GL to all.
WOW! Thanks for such detailed info. I’m not sure how much of it I absorbed beyond “proceed with caution,” so I definitely shall! 😅😉
@@stephanieilluzzi7355 You're welcome. My experiences are decidedly outside the norm as a person who had metabolic damage from chemical exposure and mercury, but it very conceivably could happen even at moderately high doses to people who are more susceptible because of genetic expression of CP450, or have sulfur sensitivities etc. in general. So caution and "starting low, ramping slow" is always the best policy, IMHO. All the best
i bet the pronunciation is changing with TIME, PLACE, AND PEOPLE
I took 2700mg of NAC for months. I now have many health issues including histamine intolerance. I wonder if this is why?
I'm 56 and DID NOT take anything you said as medical advice. That being said, it was highly useful to hear the dosages you'd take at me age. Thank you.
I take NAC and TMG once a day. I am 71. I may start taking it twice a day as I have noticed a general well being, and less inflammation (from arthritis, though I do take a handful of other supplements and vitamins, all considered safe -- no MNM, nor resveritrol or NR). NAC and Glycine are both considered generally safe supplements. I appreciate this video and information!
Love your videos! Thank you for making sense of all the information and making it accessible for us! 🙏🏼
wish he did this much research into affectiveness of lockdowns and vaccines on covid and every other cause of death.
Been using Nac and L Glutathione since, my failed TKR in 2017 that, brought on severe Arthrofibrosis and Complex Regional Pain Syndrome. I don't use opiates I researched and found out that these two supplements help with my Central Nervous System that is constantly over firing nerve damage. Im not cured but, I can say they helped with my symptoms of atrophy and chronic pain.
Very much appreciate that you show the results of the studies in numbers and explain them. That is much more valid than generalized claims "xy" helps wit "z".
Hey, Sir hope you're doing fine, I just wanted to clarify that There Is a study Showing NAC Suplimentation Does Increases The Risk Of " Adenocarcinoma Of Lungs on A Mice Stuy". JCI Insight 2019 Published On October 3rd In NIH
Hope that you can Also make a video about Supliment Including " NAC+ TAURINE".
Update please on tmg vs glycine with the nac ???
Question for Dr. Brad (or anyone) please. In Medcram video #70, 10 seconds before the 3 minute mark, Dr. Seheult shows graphically a glutathione molecule, which is composed of 3 amino acids: 1) glutamate, 2) cysteine and 3) glycine. According to the the Medcram video, NAC is composed of cysteine and glycine. So my question is why supplement with glycine if you are taking NAC, since the NAC molecule is already composed partly of glycine? In the Medcram video, NAC alone (without supplemental glycine) was believed to raise glutathione. Thanks.
ua-cam.com/video/owmE9lJf-hQ/v-deo.html
Thank you for the valuable video AND for sharing what dosage you would use. I’m 53 and a great fan of bio hacking. I healed myself with nutrition and targeted minerals (based on a HTMA with regular retests), which turned my health around completely. However, I was diagnosed with melanoma in situ. While all is well now, it made me look for an approach to heal my mitochondria, as studies have proven that the diseased mitochondria is the first step in the cancer process, not the cell itself. I found a bulk powder form of both glycine and NAC and will give it a whirl. Thank you 🙏
What brand names?
How's it working out for you?
@@thecandyman9308 So far so good. Two more biopsies - both negative! I also recently went to a mitochondrial and metabolic specialist and ordered a Genova test to check 150 biomarkers. I'll be reviewing the results on 11/17.
Interesting to learn about the cellulary mechanism and imbalance. However, what also increases the glutathione production in our body is the exercise itself. Supply all the amino acids in a balanced diet and exercise. No extra supplements needed. You are welcome.
I am so glad that you got to say "datah" at least once in this video.
I have been using low dose NAC for years. It works best in month on month off
Why?
@@alexanderohanlon8825 your body gets used to it. Cycling seems to help keep it more efficient at using it.
@@kenwin5845 thanks for the reply, t me I feel the same but I've found no studies on it showing this... But again it makes sense to me.
@@alexanderohanlon8825 drug companies would never want to admit this...who wants to stop a regular revenue stream. We have to be proactive on our health...it is our right and responsibility
@@kenwin5845 true.
After watching the video and reading through the comments, I wonder if this would also help with skin elasticity. As you age you lose collagen production AND your skin becomes thinner. I'd love to see if this would make a difference there as well. I know L-lysine (essential amino acid) plays an important role in the formation of collagen.
Believer - I take NAC every day. I'm in my 60's and it definitely improves the appearance of my skin.
Thank you so much@@linda5628! I appreciate that!
There could be. Interestingly redheads can synthesise amino acids like glutathione better, there was a recent study that showed redheads look younger on average of 2-3 years.. they didn’t mention the reasons behind this being NAC but it’s good for thought
Thank you @@eldictator1! I appreciate your answer! It gives me hope as I ordered some NAC. Anything that helps me feel better I'll give a shot.
@@linda5628 I am a female in my 60s also. How much do you take? Any side effects I should be aware of?
It is well known in the bodybuilding and powerlifting community that NAC is effective in protecting your liver while on gear. Look into TUDCA as well. A thousand times better than milk thistle.
Thanks for the review of this paper.
Excelent teatching! Thank you sr. Downloaded the article to make the homework latter on. While this, will start ASAP my supplementation.
FYI, Pure encapsulations makes a NAC + Glycine powder. 1800mg of each is the dose. I have occasionally belched a sulfur taste.
I just bought this for my supplementation stack . I’m also adding a bit of serine just in case
Have you experienced positive changes?
@@cmckee021 Nothing really. But, not expecting anything dramatic.
Another great Walk-through. Thanks a lot Brad 🙏
NAC can cause anhedonia and histamine intolerance. TMG is stimulating and not sure if long term it could cause downregulation of certain receptors.
Very well presented and articulated. Thank you for this information
wow - what a video! Thanks!
Hey Dr Brad, great video but I wanted to comment. Not everyone should use creatine (generalization). Especially those with kidney damage. That can send you into kidney failure quite quick if your body can't clear creatinine. Thank you again for the video.
Water retention in general is very underestimated in its risks, and can literally just stop your heart
Are you a doctor?
Curious to know your thoughts on the long term regular use of NAC drying out mucus membranes and causing nose bleeds.
Get checked out hot shot, been using Nac and vit c combo nearly a decade (fight colds,hangovers,covid) works wonderful everytime also am 220 jacked weight lift zero nose bleeds, SEE A DOCTOR could be a brain tumor.
Your 3g per day post-55 still seems quite a lot as most NAC supplement suppliers recommend a dosage of 600mg-1200mg per day. Do you think that lower amount could still work, together with good diet & exercise?
And does the body build up stores of glutathione such that taking GlyNac for a longer period than 16 weeks could result in higher levels of glutathione in the body?
Fact to know: NAC turns off the gene NRF2 which, when activated, turns on over 500 cellular detox pathways. I usually rec my patients rotate between NAC/Glycine and supplements/foods that upregulate NRF2 (such as curcumin and broccoli sprouts/sulphorophane)
Thanks, as someone who has taken NAC daily for a long time... i never knew this 😬
I guess i should take a break.
@scrow7752 the body is always changing :) its good to take breaks/rotations.
Look into superoxide dismutase (SOD) - another really good one to throw into the rotation. Or butyrate
ILL GET MINE ON THE BLACK MARKET THEN. WILL NEVER STOP TAKING IT
Ah, you beat me to this video. I've been following the study protocol for just over two weeks, and all I can say is "WOW". Since about six days into the regimen, my energy levels have skyrocketed. I used to lament being tired all the time, needing to take nap(s) every day, yet never feeling rested. Moreover, my mood suffered as a result. Additionally, my physical capacity for exercise has eclipsed what I was able to do before, especially in grappling and bike riding in high-heat conditions, two activities that used to kick my ass. So, I'm continuing this with great expectations. I will do blood tests after another two months, but obviously cannot access the detail level testing the study participants describe. I won't be surprised if further studies along the line of this researcher are somehow buried or otherwise quashed with new appeals to the FDA to restrict sales of NAC, which worries me greatly. Never under estimate the power of pharmaceutical agencies. However selective the criteria were, it is understandable they were done that way. Just imagine the cost of running such a study with the extensive testing and detailed tracking of so many parameters. Had they opened up the parameters too greatly, the number of weaknesses pointed out due to lack of standardization would increase greatly. Naturally, the study authors themselves are excited and have repeatedly asked to increase the number of studies and diversity of studied cohorts. The lead researcher may well deserve the Nobel Prize.
Wow! Amazing! Thank you for this detailed explanation of your experience.
How much NAC and glycine do you take? The same as the study?
@@TheReminderChannnel yes, 100 mg/kg, and I'm 59. I look forward to doing some extensive blood tests in 2 months, but in the meantime my productivity has skyrocketed more than I thought it was possible. I'm not exaggerating when I say this has changed my life, and I don't know if it's just the supplement and power of suggestion, however I've taken so many supplements and spent literally thousands of dollars a year on top level supplements for many years and never noticed such a result. If this is indeed some sort of placebo effect well, as I always say, if the placebo works it's no longer a placebo. PS: unlike a lot of supplements these go down easy and don't cause upset stomach, yet because of the number of capsules I do split them in three doses throughout the day for sheer convenience.
@@worldsokayestmedic4568 wow! I’m so happy for you! This is amazing! Are you taking them with food or on an empty stomach?
Are you taking any other supplements too?
Thank you again 🙏
So you take 100 mg of glycine and 100 mg of nac per kg? So if you weigh 70 kg you take 7 grams of glycine and 7 grams of nac?
@@TheReminderChannnel these go down really easily. Both my wife, who is very sensitive to supplements, and I can take these on an empty stomach without feeling any queasiness or anything else.
I do 1.5g of NAC 1.5g Glycine in the morning & before bed, always on an empty stomach. Don't forget 100mg of P5P on empty stomach 3 times while awake (B6, 33.5mg 3 times) for amino acid metabolism.
Do you take this capsule form? It’s SO many capsules ! If you’re in the US, where do you buy them?
I am 75 and I took NAC, GLY, NMN, Resveratrol etc for three months. I lost weight and height. My hair turned black. Now my friends think that I should join a preschool.
Amazing and awesome stuff! Congratulations 💥
Height? Just curious how?
@@dollytanwar4918 Age reversal literally.
@@texastexas4541 Have you watched his video on resveratrol? The positive results of resveratrol were found to be a lab error and couldn't be replicated:
ua-cam.com/video/JAFnD27ffqE/v-deo.html
may I know your full protocol and dosage?
Brad, your skin is looking shiny!
Another great video! I’m curious, I’ve noticed sulforaphane has not come up in your videos as of late. Has your view on this changed?
Yeah.... careful with the glycine though. It will cause an iron deficiency in a very short time. Not sure why, but glycine eats up free iron like there is no tomorrow. Restless Leg Syndrome is a dead giveaway that you need more iron. Cramps are a hint that you are getting too much iron. Be careful and stay aware. It's not as simple as "just take glycine". There are side-effects that need to be handled properly. Good luck!
In vitro or in vivo??
I love the channel, it's very interesting. I have a question, I am a 32-year-old girl, and I am worried about the large amount of gray hair that I have. Apparently it's something hereditary, but I don't think I can't do anything. I know that glutathione decreases after 45, but in another channel they explained that it is possible to have a genetic alteration that decreases levels or training, can that be true? I should go ahead and take it, is it possible to overdose? I don't know whether to check my blood levels, but I don't think it's very easy to ask my doctor, and I don't know if it's necessary.
Yes, they have requested an analysis with "sex" and thyroid hormones and iron. And I take vitamin D, which used to be deficient, although I am also worried about an overdose.
Thank you for the information you are sharing!.
Have you heard about copper I heard it reverses grey hair .
Hello Dr Brad, I see Glycine comes in both powdered and capsule forms. Which do you recommend? Also your supplement list for the ones you will take later on in life you doesn't give a brand recommendation. For those of us already in that age bracket we would love to see that. Thanks so much for the great work.
Avoid anything from communist red china!
Powder it's sweet 😋
NAC and Glycine
Vitamin D3+K2
DHEA
☝️these are all worth looking into.
I take the MY DETOXIFY brand that has no fillers 100% NAC for convie ience
@@richardprice9730 I never used it as a sweetener. Can it cause a sugar spike? My wife is a T2 diabetic. I ordered capsules just now for myself and will probably consider powder form after your comment. Cheers, Bob
Hi Brad, Have you thought of reviewing Boswellia ? I notice that Panadol now has natural pain medication option with Boswellia.
Hi, your videos are always appreciated! Could you do a video on glutathione strategies for people with MTHFR mutation? Or is it the same? Thank you!
Wow! Great results so far. I am also in my 70's and wonder if my Glycine and NAC powders could be combined in distilled water that i sip throughout the day? Would I get unwanted chemical mixture that undermins my intent?
Yes a really important unaddressed question is what the minimum dosage is to get the same increase in glutathione. No data so far it seems. Could such high doses cause kidney damage?
Hi Dr Stanfield, thanks for your videos, they're very informative and easy to follow! I'm wondering if you could do a video about the study done in mice that shows NAC promoted tumor growth? I'm currently on NAC for biofilm treatment - this supplement has had other unexpected benefits on my muscles and energy [I have SMA Type 2]. Would really appreciate your analysis of that study. Thank you!
NAC works for breaking down Biofilm?? I haven't heard that!
@@jamiesouza It's pretty cool yes, it's a lifesaver for resistant infections.
Also prescribed to my family after living in toxic mold
Clears lungs of congestion/mucous, which is bacteria on a slimy surface constantly moist, or biofilm.
i love your content, thanks for existing