NAD+ in Aging: Role of Nicotinamide Riboside and Nicotinamide Mononucleotide
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- Опубліковано 26 кві 2024
- In this episode, Rhonda explains what NAD+ is and why it declines with age. She discusses some of the popular NAD+ boosters like nicotinamide riboside and nicotinamide mononucleotide, what animal and human data says and some concluding thoughts.
NAD+ is crucial for our survival. Small amounts of it can be obtained in the diet, but the body recycles it to get most of what it needs. Unfortunately, day to day living plus normal aging can cause NAD+ levels to drop. This causes metabolic and mitochondrial dysfunction, as well as many of the other problems and conditions associated with aging like elevated DNA damage. NAD+ levels can go up when we exercise or fast, but NAD+ precursors like nicotinamide riboside and nicotinamide mononucleotide can also increase NAD+ levels in a dose-dependent manner. However, most of the data on NAD+ boosters comes from animal studies. Whether these boosters are effective - and safe - long-term in humans is still a big question.
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Chapters
00:00:00 - Introduction
00:01:01 - Aging
00:02:47 - Overview
00:07:35 - Depletion
00:09:19 - Supplementation
00:11:26 - Animal studies
00:13:47 - Cancer
00:15:57 - Dosage
00:25:44 - Human data
00:28:25 - Storage
00:29:00 - Recap
▶︎ Detailed overview of NAD+
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▶︎ Detailed overview of nicotinamide riboside
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▶︎ Detailed overview of nicotinamide mononucleotide
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www.foundmyfitness.com/geneti... - Наука та технологія
*00:00:00* - Intro.
*00:00:48* - Nicotinamide riboside supplementation in humans has been shown to raise NAD+ levels in white blood cells.
*00:02:47* - Overview of NAD+
*00:05:12* - NAD+ plays an important role in mitigating DNA damage.
*00:05:30* - Excessive DNA damage can decrease NAD+ levels by 20-30%.
*00:05:42* - Lymphoblastoid cells from centenarians show increased PARP-1 activity.
*00:05:55* - Between different species of mammals, higher PARP-1 activity is strongly associated with a longer lifespan.
*00:06:36* - *Lower organism evidence:* A second copy of SIR2, a yeast sirtuin, gave rise to a 30% extension of lifespan.
*00:06:43* - NAD+ is required for the activation of sirtuins, which epigenetically regulate a variety of stress response-related processes.
*00:07:03* - Energy stress, such as from fasting, exercise, or caloric restriction, increase the NAD+:NADH ratio.
*00:07:37* - NAD+ becomes depleted in the brain, heart, and skeletal muscle as we age.
*00:08:13* - Decline in NAD+ levels have been associated with many broad categories of clinical disease such as neurodegenerative, cardiovascular, infectious, musculoskeletal.
*00:08:48* - NAD+ supplementation has been shown to increase lifespan in models of aging in yeast, worms, and rodents.
*00:09:48* - In contrast to de novo synthesis, the predominant source of NAD+ in the body is via the salvage pathway, which is subject to feedback inhibition by nicotinamide.
*00:11:56* - Animal studies have shown nicotinamide riboside supplementation is able to increase insulin sensitivity, increase endurance and strength, reverse mitochondrial damage, increase mitochondrial biogenesis, and reverse muscular atrophy.
*00:12:30* - Nicotinamide riboside has shown positive effects on the brain in animal, such as increased neurogenesis, decreased cognitive deterioration, decreased amyloid-beta production, and increased synaptic plasticity.
*00:12:50* - Nicotinamide mononucleotide has been shown in animals to counter an obesogenic diet, improve markers of metabolic health, improve heart function, and improve cognition and memory.
*00:13:10* - A 12-month dietary study of nicotinamide mononucleotide suppressed age-associated body weight gain, enhanced energy metabolism, promoted physical activity, improved insulin sensitivity and plasma lipid profile, and ameliorated eye function and other pathophysiologies in mice.
*00:13:47* - NMN has been shown to increase cancer progression in a specialized senescent cell-dependent pancreatic cancer model in mice.
*00:15:57* - Plausibility of dosing: comparing animal and human doses.
*00:18:05* - Tissue-specific metabolism and bioavailability of NR and NMN.
*00:24:32* - Oral administration of NAD produces NR and NMN in the intestine.
*00:24:19* - Intravenous administration of NAD, rather than its precursors, shows interesting results: an increase of NAD content and sirtuin expression in the hypothalamic region of the brain.
*00:26:15* - *Human study #1:* 250mg of NR + 50 mg pterostilbene increased blood NAD+ levels by 40%, while a double dose (500 mg NR + 100 mg pterostilbene) increased blood NAD+ levels by 90%. Additionally, there was a decrease in blood pressure, and ALT (a marker for liver health).
*00:27:12* - *Human study #2:* 500mg NR twice daily for six weeks increased NAD+ levels in white blood cells by 60%.
*00:29:08* - Concluding thoughts and recap.
00:13:47 - NMN has been shown to increase cancer progression in a specialized senescent cell-dependent pancreatic cancer model in mice.
Yikes..that's scary
Such research developments, give all of us hope, for more youthful longevity on the horizon. I hope scientists like you and others who are similarly dedicating their lives to the study of anti-aging medicine, will discover the Human immortality reality holy grail within the next decade or two. I don’t wanna leave this plane of existence, just yet. With all my heart I would love to live beyond 120 years, not as a crusty old fart, but as someone Trapped in their 30s. Time is running out for all of us who are long past half a century in age. Our hopes and dreams are in you, and your colleagues. We wait in great anticipation for your latest developments and understandings in these regards.
Scary for mice, yes.
Suzanne Ito scary for humans too. We use mice to help predict outcomes or give insight into medical research possibilities for humans. We share sixty percent of our genetics with mice.
Not raining on anyone's parade here. Let's stop for a second and think. They have been searching for a single molecule in a pill that could extend life for going on 60+ years now. Nothing has been found to be effective yet. NOTHING. What makes us think the next 60 years will be different? The only think that works is plain hard work and sacrifice - eating healthy, sleep more, exercise, fasting (still debatable), and caloric restriction (prohibitively hard for most people). Where is the pill in that. Do you see one? I don't. I am above average optimistic person precisely for the reason that life has a definite start and endpoint.
Congratulations Rhonda you have smashed the record for total mentions of "Nicotinamide and Nicotinamide Mononucleotide" without stuttering, giggling or entering a comatose state. Kudos!
Chuck A or saying NR or NMN. I don’t think she’s abbreviated once. The more you say it out loud the easier it becomes. I’m certain it helps with warding off cognitive decline also.
I have a stutter issue sometimes... hope its from anxiety
@@amperage8032 Yes, the video would have been about 15 minutes shorter with some abbreviation. Ribo and Mono would work for me...great info though.
Did you mean qudos?
Kudos was a snack bar in the 90s.
@@amperage8032 🤣🤣
Concise, comprehensive, and articulate. I don't even need to speed it up to get through the information. Well done.
pablopolski cuz she’s one of few on YT that speaks pretty quickly which I appreciate
David Lloyd-Jones spoiler alert.
You probably divorced more than twice and you never let anyone else talk.
I’m joking
@@KaneCiticani Nope.
David Lloyd-Jones Yep
David Lloyd-Jones Cause it’s a joke, you can’t say nope 🤪🤪
How Lucky we are to have Dr. Patrick in our lives. She is amazing. Knowledge just oozes out of her..
I'm 66 years old. I started taking 1g a day of Apigenin a few months ago. Apigenin is one of the ways to raise NAD+. It is amazing how much energy I have now. It feels like the energy that I remember having in my 30s. In addition, in conversation with my neighbors, they have commented that I seem to look younger every year, instead of older. I also take Metformin, even though I do not have diabetes. I also do a lot of intermittent, 3 day water fasts. I'm planning to start on 1g of Fisetin a day for 5 straight days every month in the next few weeks.
My diet is free of meat. I do eat sardines, salmon and flounder. Lots of nuts (Walnuts, Cashews), seeds (Flax, Hemp, Chia). Dark Chocolate (80% cocoa). I do drink lots of coffee. I don't drink cow milk but almond milk instead. I don't drink alcohol.
Live Long Enough to Live Foreever.
@Peter Davila I take Metformin, too. Cleared liver enzyme and liver glucose issues almost immediately. Lost a few pounds too. I'm on a "low dose" of 500 mg. I'll look into the Aligenin. And the Fisetin. Thanks.
Not to "sharp-shoot" your comment, but the best nuts (common) are pecans and almonds. Lowest in polyunsaturated fat, more like animal fat. Cashews are legumes, not nuts, I think. Walnuts have value in other ways. Thanks again.
@@ownpetard8379 Pretty cool. Good luck.
I just ordered CaAKG. I start taking that as well next week.
I still take Metformin, Apigenin and Fisetin. I just turned 67 and I feel great.
@@peterdavila3045 I'll look into that CaAKG. If I take a typical calcium supplement, it makes me feel relaxed, but it also shuts down my bowels. Whatever else it does, if it avoids the shutdown, it would be a plus.
@@ownpetard8379 Almonds are [I think]. the only alkaline nut. Good thing.
@@ownpetard8379 Cashews are not legumes. Either called nuts or seeds! They form at the bottom of the cashew fruit. Have to Google it because it's a strange process to end up with the edible cashew.
What a herculean effort and a testament to your ability to grind it out for hours on end. You’re incredible Rhonda.
few notifications on youtube get me as excited as a video from Dr. Rhonda Patrick.
5 months later and I'm still coming back to relisten to this video. Very informative and so well put together.
This is the most comprehensive video I have seen on this topic. You are a gem. Thank you.
Great video Rhonda, thank you for all you're doing and the quality information with such strong scientific detail.
Great presentation, thank you so much. I take NAD with R-Lipoic acid, D-Ribose and Resveratrol for a pre workout. I work out 3-4 times a week and feel as good as when i was 40, now 60.
What brand of each are you liking ?
ua-cam.com/video/TViYsaUM8uk/v-deo.html
How many mg Nad do you take?
@@lifeisforlivinghereandnow877 I'm about
I simply love your style of presenting with the latest facts. You speak fast, which I like! The data you provide and the research you do prior to presenting makes you one of the best health span advocates on UA-cam. Thank you Rhonda! ♥️
This is definitely the best most informative and comprehensive piece of information so far delivered on this topic as far as I am concerned thank you for this video
Excellent lecture, well put together, a good balance of pros and cons, useful diagrams and a clear summary at the end. Perfect presentation technique.
Perfect presentation
@@sleepsmartsmashstress740 I coq10
@@sleepsmartsmashstress740⁰
I've been taking 1g of NR daily for 2 years. I find that I don't get jet lag or hangovers anymore. My contribution to this fascinating science.
Jason Humm What Brand are you taking?? I’m using TruNiagen by Chromadex.. but only 300mg a day.
3x that would get kinda expensive, no??
@@drewp1974 I have a triple subscription to TruNiagen. Can't put a price on life extension 😎
Have you noticed other benefits? Changes to endurance, recovery, overall health?
@@swimbait1 I was already healthy but joint pains after heavy workouts have stopped.
So great to have the micro cellular pathways broken down this way. Also, the analysis of both animal and human studies. Thank you so much for the effortless way you explain potentially mind boggling processes. Helps so much in the decision making process.
Been looking into this a bit recently. Thanks for the new upload, Rhonda! 👍
I learn so much here by your presentation and documentation. Thank you Rhonda for taking, what must be a lot of time to put all of this documentation together!
Best video I’ve seen on the subject.
Thank you!!
I could look and listen to her all day.
Thank you . Please do not stop helping people the way you do.
I really appreciate the chemical reaction explained to me along with the reaction diagrams. So rare to find anything this thorough
Not so rare Dr. Gary Null was teaching us this material for over a decade on WBAI and now on PRN.fm, not to mention the many books he has written, the AIDS patients he cured including one famous basketball star and the diabetics he cured. You can look up old episodes of the Tony Brown Journal for some documentation.
Dr. Rhonda this is the best explanation I've heard on this topic. So thorough and well thought out. Thank you❤
Yep ! Nobel prize candidate !!
Just found your channel/videos. Your presentations are "spot-on," as the modern expression has it. Loaded with information. Love your vids. I shall be watching them all. PLEASE keep up the good work !
Best unbiased recap of NAD+, NR and NMN. Thank you! Suscribed!
A very professional very well presented lecture . English is my 4th. language and I did not have any real problem to understand it and learn from it. Doc, I really appreciate your effort to create this video. Thank you.
So glad you covered this. Been listening to lifespan on audio book and he's one of the leading scientists on this research.
You remind me of my favorite med school professor- one of my favorite instructors of all time
Thanks for the clear and concise video!
Holy crap, this was amazing. This 30 minute video took me 2 hours to get through. Had to pause and read and then pause and research. Thank you!!!
Exemplary summary. I love how dense with information your videos are. Quite a rarity on youtube! Keep up the good work and thank you for your high quality content!
Dr. Rhonda, the people's champion! 😁
This is just about the most thorough and intelligent PP presentation I've ever seen. She is one smart lady! Wow.
Congratulations!
Firstly for the , pleasant, patient presentation, with amazing revelations of test results of NAD, decline with age, using boosters of NAD, & Alternate pathways which work usually but with exceptions!!!
Extremely A Great MASTERLY STUDY/ & presentation of all pros- cons of all eventualities .
With a final recap!!
Thanks for this useful educative share! Many regards!
DOC!!!! your the best! I wish there were more docs like you.
Superb presentation!Thank you for making a potentially difficult discussion very manageable.
Because of you, I started loving myself with broccoli sprouts. ❤️ I grow them too. Sulforaphane for the win! Thank you 🥦
Why? Is their benefits?
Thank you so much for the thorough long-form video, all of this information is very important.
The best all-in-one-video on UA-cam that explains NAD+
Rarely do we find in the study of nutrition, detail like presented in this video, yet at the same time Rhonda is able to get to her final conclusion without leaving everyone in the weeds. Extremely well done. Combined with Dr. Nicholas Pericone and Dr. Jason Fung, we are starting to get a handle on what is necessary to make critical changes in our life for optimal health...
It is a fascinating topic and I love how scientific Dr. Patrick approaches it!
She's the most articulate legitimate research scientist I've ever come across. I filled a pool full of NAD+ boosters and I take 10 laps every morning, sipping as I swim.
@@JunoBeach1944 I am finishing my PhD soon. Maybe she is looking for young PostDocs in her lab :D
Love your channel man, good to see you here :)
@@KekeeBlack Always very happy to hear that. Thanks :)
Dr. Patrick is just a great source of information!
@Zeek Banistor Nice to meet you, George.
Best presentation on the NAD/NMN potential and current status I have seen anywhere.
Stellar presentation as always, thank you Dr. Patrick!
Thank you so much for bringing us this information Doctor. Using your great intelligence for altruistic purposes is both rare and wonderful.
You are amazing!!! This material is so useful!
Thank you Dr Patrick this is above and beyond anything that is out there.
I like to watch informational videos like this while doing my hour of piano warm ups. Nope....can't do it on this one. Need to give this video my 100% attention. Thanks Dr. Patrick.
What a masterpiece! Thank you!
Great video. I am 70 and a health fanatic, and still in perfect health. I have a massive coordinated program that did not include this. Now I will be going out today and buying Niacin. I am going to start immediately. Have a wonderful day. ☺😎🐰
It appears that Dr Rhonda does a lot of preparation and compilation of subject matter for making each video. Her tone and presentation skills are excellent. She seems to be interested in sharing her in depth knowledge for the good of the people. God Bless Dr Rhonda Patrick 🙏
Thank you, Dr. Rhonda Patrick! Great information!
Damn. I need an IV of this channel straight into my brain. Oh, and that other stuff you were talking about, as well.
i think they do niacin on a IV and the results are pretty good! they do a quick iv push that takes like 5 mins but its pretty uncomfortable on the subject. However the results again are very good
@@robertjopling9217 Is this above the sorts of levels you would find in a healthy diet?
Piñata Oblongata totally much higher , it’s not cheap either , for a regular b12 Iv it’s about £600 not sure on the 5 minute push Iv ?
@@robertjopling9217 So what evidence supports such doses? How long does last in the system? What are the effects?
Me too😂💯
Excellent lecture.
Thank you for this presentation Dr.
Cheers
@Zeek Banistor can we both agree that her title allows her to be addressed as "Doctor" ? LoL
Cheers
Thank you Dr. Patrick I appreciate the honest review as someone who was just looking into this I really appreciate the data and information you've brought forward. Please continue to be an Amazing Doctor! ❤
This is a wonderful video. We will probably be sending our patients this video when they ask about NAD+ from now on!
NAD+ is a miracle drug and no mistake. The hype is real. It has had a profound effect on my mental and physical health at the age of 41, after many years of drug abuse, persistent old injuries, and the general exhaustion brought on by 25 years of OCD and sky-high anxiety.
How.many mg do you take?
@@lifeisforlivinghereandnow877 I actually get it intravenously, at a clinic, 3 times a year to keep my blood levels high. In between I take it nasally, 15 mg at a time, twice a day, so 30 mg total, $120 for a three-month supply.
Intravenous NAD is ~$700-$1,000 a session, 5-8 hours a day (the higher cost is for treating serious disorders, for longer), but if you can afford it, it is WAY more powerful than if taken orally, sublingually or nasally. WAY more powerful. They should be doing studies on IV NAD, not oral, because it is there that they will find the effect.
@squamish4244 where do you get the nasal spray?
Here for the nasal spray! I had my first 200mg NAD IV. Was one of the worst 60 minutes of my life 😂😂😂 But the benefits by far outweigh the risk!!! I also love the 200mg shots. Want to start the injections myself to save some $$$
Thank you for such an educational clip . Please keep it up
Good work! You certainly did the research and can explain it with great accuracy. Thank you.
Wow amazing job and the best, most concise source of information I've ever seen for NAD oh, great job!
I'd like to see you do a video on the role of Niacin (Nicotinic acid) on supplying the molecules for the manufacture of NAD+
Amazing video. Thank you for the brilliantly explained content.🇿🇦😎🙏
What a great video doc.
I saw you in person once but did not want to bother (Fashion Valley). I would consider you to be one of my hero’s in the health field… I’ve been greatly inspired by you and Dr.Sinclair to understand health from a scientific basis in hopes that I can pass this knowledge onto my mother who has MS and the rest of my loved ones.
Thank you for what you do.
Superb. So much information explained so efficiently in 30mins. I feel very well informed now, thank you!
The year is 2063, Dr Rhonda Patric still looks 23 and now posseses levitation has awakened her 3rd eye.
I would love to awaken her 3rd eye ;)
My buddy and I always make similar jokes
Do you her real age is 73?
Your crazy
😂
You’re so smart it’s scary!!!!!
Excellent and brilliant work. Thank you very much indeed. The literature reviewers are amazingly detailed and strikes the key points of the findings from the researches.
I think you can't make more concise and comprehensible than this
I'm exactly 180lb, thank you for this vid!
Dr. talks to us like we could really get it....I do!!!
Thank you for being honest and thorough. You are the best
Exciting developments. Great to know scientists are working so hard on our behalf in this crazy world. In the meantime I'll continue my exercise, sauna, and clean diet. Thanks!
I’ve been taking 750mg of NMN + 500mg resveratrol for 6 months. I’m 61 and in good, but far from great shape. My muscle stamina and overall energy are way higher than when I began. I also have noticeable reduction in inflammation in my leg that was damaged in an accident and where it had been chronic for many years. The reduction in inflammation alone keeps me on it, but feeling a lot better is great too.
If you don't have acsess to NMN or NR, is it still a good idea to supplement directly with NADH?
It says it should be taken on an empty stomack in the morning, and perhaps I can fast as well for a few hours after consuming it.. And then break fast with a little meal, and add reservatrol and quercetin etc. to enhance the effects? Will that still be good? (Using NAD supplement, instead of NMN or NR, is basically what im asking). And if so, how can I best enhance the effects?
@@Shaylas please be careful. Even the highest dose study was barely absorbed...there is no long term clinical data. Even in IV form data is very limited ...almost all good news was fr animal studies
@@sirt1353 I would say make an appointment with a naturopathic doctor. Self medicating with supplements can provide good symptoms, but may have insidious effects. in the video at the end, she mentioned she is not ready to jump the gun on the efficacy of NAD boosters
Tom y Melon thanks for the advice. I have direct, personal evidence of its benefits and effectiveness. I’ve lost 15% of my body mass and had pretty severe inflammation related to a leg and ankle injury that is gone since starting the regimen. I haven’t felt this healthy in 15 years, so I’m going to keep going thank you very much...
Which brand do you take? Thank you
She’s awesome
Great concise presentation as always. Thank you.
So helpful + informative for learning about aging. Thank you for this video!
I weigh exactly 180 pounds... this is great.
Not if you're 4' 11"
That's funny. Are you taking NR or resveratrol?
@@justinajones3000 Both.
@@MrJamesdryable Thank you.
@@MrJamesdryable Well, you're you auditing this course, then. 😄
I've been taking a low doseage of NMN for a couple of weeks now. I started with 100mg in the morning and 50mg at night on the first day, then 50mg the next morning. I hadn't been expecting any results for at least a week or so. About 2 hours after taking that second morning dose I went out shopping and was astonished to find my legs wanting to walk faster and faster, as if under their own volition. I've not walked like that in almost 7 years.
I've had a number of strokes and suffer numerous symptoms, manly to do with inhibitted activity levels.
My mind is foggy most of the time and the NMN has not done anything for that, but I certainly feel the difference in energy levels, it's really amazing.
I also found that after a few days I had to stop the NMN for a couple of days as it seemed to be making me feel more groggy, so I now take it 2 days on, 2 days off.
The brand I'm using is an American Brand called RevGenetics, and it's called Advanced NMN, in capsule form. I know it's also available in powder form too. It's quite expensive even in capsule form and would cost the earth to take it regularly at the doseages recommended in this video, but I can assure anyone that the effects at the doseage I am on are truly amazing.
I also started NAD plus at night .. bad idea I had too much energy 😂 I’m very sensitive so I find out pretty quick.. let’s hope 🙏
WOW! I'm so happy for you. Life can turn out okay. Yay! from Oz
THANK YOU SO MUCH!!!! I AM LOOKING FORWARD TO VIEWING OTHER VIDEOS FROM YOU!!
Amazing content as always Rhonda.
Yessss, feed me knowledge
So I can apply knowledge to my feed.
Very nutritious xD
I just hope she appreciates me keeping this comment classy.
-Thank You, Rogan again soon?
its bonkers to conceive that this is free. ty Dr Patrick
Thank you so much for giving this teaching on this topic. Valuable information!🥰
Valuable information How ?
Great video Rhonda!
I was wondering if it makes sense to take a NR/NMN supplement while also ingesting carbs/protein/fat.
As you also explain in the video, the NAD/NADH ratio in the cell increases when fasting/CR/exercising.
Then such a NAD boosting supplement would need to be taken in a fasted state wouldn't it?
Or is the pathway of either NR/NMN supplement somehow separated from the metabolic pathway when a cell is in a fasted state?
I personally get NAD IVs@24:30 and use them with my patients and notice an increase in energy and improved cognition.
Weren't those banned by the fda?
Do you know if it helps with depersonalization/derealization....or is it being sold as snake oil for that?
@@viorelg9499 has it been banned?
Can you supplement with NADH directly? If so, how much mg is considered safe and effective?
@@sirt1353 NADH Birkmayer is an expert he is from Austria and i know it works! Check him on UA-cam for normal health 40mg is ok. For Alzheimer up to 80mg a day mostly take in the day. It helps with alertness and jetlag too
Love the videos! Still want to see more Dr. Ames!
Congratulations 🎊 - It's pretty rare to be able to see such good quality presentation for so complex topic and compressed in so condensed time
Thank you for the video. I have been taking Tru Nigen (NR) for about two months at 350 mgs. What I have noticed is a slight increase in energy, and focus. I feel like I have also lost some body fat. However, I stay in Ketosis and use intermittent fasting 4 days a week. However, I plan to stop taking it once my bottle runs out because of the information presented in this video. I don't see the benefits outweighing the potential downsides. Thanks again.
Sometimes the damage to your body takes longer to repair.
Please Rhonda, the Floxing community needs you to make a video about Fluoroquinolone Toxicity!
FYI : Mercola has some good articles on that topic.
His most recent one >> articles.mercola.com/sites/articles/archive/2019/01/09/antibiotics-trigger-heart-disease.aspx
and those listed in a search >> search.mercola.com/results.aspx?q=Fluoroquinolone#stq=Fluoroquinolone
I keep waiting for a major public figure to come out with floxing and bring this major public health issue to light but it never happens. I'm 8 years out and now at 41 years old I have no more friends, and family just look at me like I have simply been a weak unambitious whiney loser all my life whereas I used to be strong, athletic, passionate about many subjects, a polyglot, a musician, a dancer, a traveler... You just learn that our existence is insignificant and we should never expect people to care about anything but their own problems. It's extremely humbling but hey we gain a perspective on life most people never get until maybe their last breath.
@@davlmt i feel you :( I can relate to a degree. All the best❤✊🏻
That was a very thorough explanation Dr. Patrick. Thank you.
Your knowledge of physiology and biochemistry is quite striking.😁
Very helpful - comprehensive - much appreciated!
For very different reasons, NAD+ has also attracted a wave of attention from cancer researchers. Recent studies suggest that cancer cells of many types depend on NAD+ to sustain their rapid growth and that cutting off the NAD+ supply could be an effective strategy for killing certain cancers. The data from these studies paint a more complicated picture of NAD+ and raise new questions about the diverse ways taking an NAD+-boosting supplement might influence health. “It might still slow down the aging part, but it might fuel the cancer part,” says Versha Banerji, a clinician-scientist at the University of Manitoba. “We just need to figure out more about the biology of both of those processes, to figure out how we can make people age well and also not get cancer.” This is just a fellow up to my previous post. Interesting that most sites are ignoring the possibilities of its effects on cancer.
I decided to add some links for support into the need of discussion about NAD and certain Cancers.
After yen years cancer free, I was diagnosed with Lymphoma. Just finishing my six months of Chemo. The Cancer reappeared
just after 5 month of NAD. Brand was TRU NIAGEN.. THEY HAVE FAILED TO RETURN MY CALLS.. ANYWAY,
HERE ARE THE LINKS I WISH I HAD READ BEFORE STARTING NAD
www.scientificamerican.com/article/cancer-research-points-to-key-unknowns-about-popular-antiaging-supplements/
www.frontiersin.org/articles/10.3389/fonc.2018.00622/full
www.ncbi.nlm.nih.gov/pmc/articles/PMC6315198/
www.mayo.edu/research/centers-programs/cancer-research/research-programs/gastrointestinal-cancer-program/mayo-clinic-pancreatic-cancer-spore/research-projects/targeting-nad-catabolism-pancreatic-cancer-cells
My only wish is that they put into the selling of their products, " the possibility of Cancer.
Very interesting episode. Fantastic work!
One question comes to mind:
We know that resveratrol is a SIRT-1 activator but are there identified compounds that increase PARP-1 activation (for us with non-supercentenarian genes)?
I supplement with NR and resvetral. If there's a PARP-1 specific activator compound, it might be an interesting addition to the mix.
Loved your interview with Dr. Daivid Sinclair! The meeting of two great doctors! Hope you have another with him! Maybe get a pre-copy of his new book to come out soon for an interview?!
Thank you! This is wonderfully insightful.
** Due to a serious case of mold poisoning I have been on NAD+ IV's for 6 months... they literally saved my life.. I have never had oral NMN or NR. However I would highly recommend anyone with a health issue try NAD+ IV's. There are numerous accounts of people turning their life around due to NAD IV's not precursors. Best wishes to each of you!
Thank you Rhonda I will watch this again you explain NAD+, NR and NMN excellent easy to follow. I will come back to this video on referencing one of the best out there. God Bless you.
Awesome, best NAD video so far, you saved days of research in such information dense video, awesome work
Hello! Would love to know your thoughts on methyl group depletion as it relates to Niacinamide supplementation. I have been taking it at 500mg/day, with no ill effects. However, I am cautious about the long term affects of supplementation.
Thanks! And love your content!
Seems Fasting, calorie restriction and exercising is about the only thing that works for the moment. No magic pill. Great information 👍
Also NR and NMN
Chris Brown how much to take of each of those together per pound of human weight? And I got the impression iv was more effective than pill form.
@@vinster9165 But oral is still effective enough to make an impact
Diet and fitness are important, but it won't increase NAD. We need to take NR or NMN to raise NAD.
@@dmana3172 No evidence that taking precursors to raise NAD will do anything that you think it will.
Thank-you Rhonda!
This is an excellent summary of the literature. Thankyou