1.Pharmacogenetic conditions: Introduction - General Pharmacology Lectures

𝐒𝐮𝐛𝐬𝐜𝐫𝐢𝐛𝐞 𝗙𝐨𝐫 𝗠𝐨𝐫𝐞 𝗜𝐧𝐟𝐨𝐫𝐦𝐚𝐭𝐢𝐨𝐧 𝐨𝐧 𝗛𝐞𝐚𝐥𝐭𝐡 👩‍⚕‍ 𝐚𝐧𝐝 𝗠𝐞𝐝𝐢𝐜𝐢𝐧𝐞💉🩺💊
📌𝗜𝗻𝘀𝘁𝗮𝗴𝗿𝗮𝗺 : / clinical.learning
Pharmacogenetic Conditions: Bridging Genetics and Drug Therapy 🧬💊✨
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Pharmacogenetic conditions lie at the intersection of genetics and pharmacology, where an individual’s genetic makeup directly impacts their response to medications. 🌐🔬 These conditions arise due to genetic variations (polymorphisms) in drug-metabolizing enzymes, drug transporters, or molecular targets, leading to altered efficacy or adverse drug reactions (ADRs). For example, a genetic variation in the CYP450 enzyme system can cause a person to metabolize certain drugs too quickly (resulting in no therapeutic effect) or too slowly (causing toxicity). ⚙️🩺
These genetic influences are not just theoretical; they have real-world implications. Disorders like G6PD deficiency predispose patients to hemolysis when exposed to drugs like antimalarials or certain antibiotics, while polymorphisms in genes like CYP2C9 and VKORC1 affect the dosing of critical drugs like warfarin. 💉📊 The field of pharmacogenetics highlights the importance of personalized medicine, tailoring drug therapy to each individual's genetic blueprint for safer and more effective treatment. 🌟🌍
By understanding pharmacogenetic conditions, healthcare professionals can predict drug responses, minimize risks, and optimize therapeutic outcomes, moving closer to a future of precision medicine. 💡✨
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[@amolkelkar7231]

Nice video

[@medschoolsimplified007]

Thanks