What does your CCP test mean?

Curious about the anti-CCP test and its significance for your health? We’ve got you covered! Learn how this simple blood test revolutionized early detection of rheumatoid arthritis and opened the door for game changing treatment approaches. Also hear about new insights we are STILL learning about this blood test and what it could mean for you.
💡Video Key Takeaways
1. The anti-CCP antibody test is a common auto-antibody test used in the evaluation of rheumatoid arthritis (RA).
2. It detects antibodies against cyclic citrullinated peptides, which are proteins with citrulline amino acids.
3. The presence of anti-CCP antibodies is highly specific for RA, aiding in early diagnosis and treatment initiation.
4. Positive results indicate a high risk of developing RA or experiencing severe symptoms, prompting proactive management strategies.
5. Recent research has uncovered that certain types of anti-citrullinated protein antibodies may actually provide protection against developing rheumatoid arthritis (RA), adding a new layer of complexity to our understanding of autoantibodies in the disease process.
⏱️Time Stamps:
0:00 Intro
0:28 What is the anti-CCP antibody? (quick Biology class!)
3:50 What does the anti-CCP test mean?
5:22 A +CCP test may mean high risk for RA
6:36 anti-CCP antibody test in the real world
8:31 Convo Starters (Qs for you to ponder and discuss with your doc)
🔗 Links:
Your Appointment Home Run Handbook - Rheumatoid Arthritis edition! - connectedrheumatology.com/app...
Everything you need to tell your doc your story and find out if you have RA once and for all!
🎥 watch more:
Top 10 Facts about Rheumatoid Arthritis- Part 1: • Top 10 Facts about Rhe...
Top 10 Facts about Rheumatoid Arthritis- Part2: • Top 10 Facts About Rhe...
5 things you need to know about your +Rheumatoid Factor: • 5 Things you need to k...
📖 References:
1. loan-Facsinay, A. et al, Anti-cyclic citrullinated peptide antibodies are a collection of anti-citrullinated protein antibodies and contain overlapping and non-overlapping reactivities. Ann Rheum Dis. 2011;70:188-193.
2. Demoruelle, K. The Changing Paradigm of Anti-citrullinated protein antibodies in Rheumatoid Arthritis. Arthritis & Rheumatology. Feb 2024; 76(2): 178-180.
3. Avouac, J. et al, Diagnostic and predictive value of anti-cyclic citrullinated protein antibodies in rheumatoid arthritis: A systematic literature review. Ann Rheum Dis. 2006;65:845-851.
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👩🏻‍⚕️ About me:
Hello! I am Dr. Elizabeth Ortiz and I’m so happy you are here. I am a double board certified Rheumatologist with over 15 years experience practicing Rheumatology and am passionate about teaching & empowering patients to partner with their doctor.
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* The information in this video is not intended nor implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained in this video is for general information purposes only and does not replace a consultation with your own doctor/health professional. Any comments and/or recommendations made in the comment section by anyone other than Connected Rheumatology does not reflect the opinion or recommendation of Connected Rheumatology.*

[@arimaharaj4268]

This was very informative on so many levels. Thanks much.

[@ericapoe]

Dr. Ortiz could you discuss drug induced lupus? I was diagnosed with it after using Humira.

[@pattyherman6707]

So clear and helpful! Thank you

[@molanaroomi7431]

Keep smiling ❤

[@barefootbythecreek4859]

Can you do a video about histone testing what it means? And drug induced lupus and more about Crohn’s ibd from rheumatology standpoint point.

[@brandymoddison2055]

When you talk about symptoms lasting "3 months or longer" do you mean 24/7 for 3 months, or coming and going for at least 3 months?
Also, what are your thoughts on the idea that the various antibodies that we test should really be zero for the most part, and that being "within range" per the lab's thresholds doesn't necessary mean the result is completely negative? Some consider this "mildly" positive.

[@pearlkally8325]

Hi Doc, Would you please talk about Chillblain? My husband has this on his toes and we have no idea how it comes about and what to do? Thank you very much!

[@barefootbythecreek4859]

Can you do a video on crohns I watch your videos but feel out of place lol because I see a rheumatologist due to extra intestinal manifestations with Crohn’s disease.