The Story of Sceletium

The plant medicine that packs a major punch to feeling good!
Sceletium is a nootropic - a supplement that is ingested primarily for its effects on the brain - due to having high affinity as a serotonin transporter. Modern research now supports the efficacy of this traditionally employed compound for enhancing positive mood and cognitive function, reducing stress, and inducing calm without sedative effects, and, very importantly, without inducing dependency.
Two main mechanisms underlie sceletium’s effects. First, it acts as a natural selective serotonin reuptake inhibitor (SSRI). Sceletium binds to serotonin transporters, inhibiting reuptake of this neurotransmitter from the synapse of serotonergic neurons, resulting in an increased serotonin concentration in the synaptic cleft, in the same fashion as prescription SSRIs.
Sceletium’s second mechanism of action is in inhibiting phosphodiesterase-4 (PDE4). PDE4 is an enzyme that hydrolyzes cyclic AMP (cAMP) and is highly expressed in brain regions involved in memory, anxiety and depression, including the amygdala, nucleus accumbens and hippocampus. Animal models suggest PDE4 inhibitors can reverse depression, improve cognition and alleviate anxiety. SSRIs treat depression by increasing levels of serotonin in the brain. Serotonin is one of the chemical messengers (neurotransmitters) that carry signals between brain nerve cells (neurons). SSRIs block the reabsorption (reuptake) of serotonin into neurons.
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One of my absolute favourite plants

[@lindseywagner3841]

Brilliant!!!