T Cell Receptor Activation

Now that we know about T and B-cell development, let's learn about T cell receptor activation. Only certain T cells are allowed to differentiate into mature T cells, whether CD4+ or CD8+. How does this work? Let's find out!
Script by Niyati Vachharajani
Select images provided by BioRender.com
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[@shreyvarad]

best sci-comm channel. no argument.

[@tempname8263]

I've read that as sitcom... which actually fits as well

[@shreyvarad]

@@tempname8263
honestly, with how much he shits on anti-science spewing charlatans, it might as well be...

[@wernwin]

@@shreyvaradwant some bread with that hot dog

[@tempname8263]

@@wernwin *laugh-track*

[@hardoise667]

You're one of the few with whom I can allow myself to tell people "No guys, there's good on youtube"

[@donchristie420]

Good job on the script,Niyati😊

[@mangogo21]

Hey Professor Dave. I was just wondering at 4:31, your diagram had MHCI binding to CD4 T cells, and MHCII binding to CD8 Tcells. Shouldn't it be the other way around?

[@universeusa]

Thanks 🙏
Awesome UA-cam channel
We learn a lot 👌👍

[@kacemmekni]

good job

[@nicholasgardiner9601]

Thanks Professor Dave, great elocution.🎉❤

[@Tyler_Durden987]

Thank you Niyati Vachharajani

[@RiyadhSaleh-g4o]

4:29 MHC II binds with CD4+
MHC I binds with CD8+

[@brian5663]

Dear Dave, thank you for your excellent way of educating the public. I do get a great deal of help from your video and enjoy this kind of learning. I am a new member (study buddy) here. I wonder if I am qualified for early access to the hidden videos in Immunology. I am going to take an exam in a few days...

[@DylanMc329]

Is it possible you could do a video on hiv medicines out there and explain how they work and their effecacy? Symtuza is a brand im interested in learning about.

[@TheCrossroads312]

FYI the schematic @4:36 has CD4 and CD8 flipped

[@FrogUniverse]

4:35 The image on the left should show a T cell labeled as CD8, not CD4. CD8 is the co-receptor that interacts with MHC class I molecules, which are presented by nucleated cells. CD4, on the other hand, interacts with MHC class II molecules, which are presented by antigen-presenting cells (APCs). It looks like there was a labeling error in the diagram. 4:42 there is a labeling error in this image as well. The diagram shows CD4 pointing to MHC I and CD8 pointing to MHC II, which is incorrect. The correct associations are:
CD4 should be pointing to MHC II.
CD8 should be pointing to MHC I.
This is because CD4+ T cells (helper T cells) interact with MHC class II molecules, while CD8+ T cells (cytotoxic T cells) interact with MHC class I molecules. 5:00 As you can see here the top diagram contradicts the bottom. labeling in the bottom image is correct. Here’s a brief overview:
CD4+ T-cell interacts with the MHC II complex on a macrophage.
CD8+ T-cell interacts with the MHC I complex on an infected cell or cancer cell.

[@Huebert-zp8uq]

Do you think you could do a video on positive and negative selection in detail? We covered it in courses but it was one of the more confusing topics. Going through things like the antigen presented during positive and negative selection, AIRE etc. I think it’s a high yield topic that also lets you explain autoimmune a little and how the system can go wrong

[@0xoRial]

good timing for my immunology exam

[@shelbyg6342]

This is what I study for my job! My company creates CAR T Cell therapies for cancer treatment.

[@pramodsingh7569]

Thanks

[@jamiegallier2106]

Thanks Dave!

[@keegan6388]

hey professor farina, are you ever going to cover nuclear + radiation physics? i feel like a general explanation of radiation science in your style would help to dispel a lot of the anti-nuclear rhetoric in north america and europe

[@donchristie420]

Things going well,Wael
(Been trying to find the time to learn more about Lebanon)

[@NuNugirl]

Dave can you please explain the effects on B cells after splenectomy, because I have ITP. Thanks.

[@josemadrid2913]

So can the more knowledge about T-cells are able to help in the fight against cancer?

[@sbindoctor6414]

Please do a video on Dr. Fatima's videos and/or the Dark Matter doesn't exist conspiracies

[@noblewatcher5732]

Nice , I'm early.

[@defiant4759]

T Cell therapy is being tested to help with Autoimmune diseases like Lupus.

[@Hungary_0987]

Who thinks about how cool it woulf be being a T-cell?

[@scorcher64]

It would be.
On the other hand, I also imagine being a helper T-cell running for my life as I'm being hunted down by HIV wanting to latch onto me 🤣.

[@alexmeredith6923]

good video, by the way have you heard of a creationist called dr jeff tomkins

[@petelewis7313]

Please can you do a video on the "science" transcendental meditation presents to support the argument they can stop crime and levitate amounts other things . I am trying to help my friend who is planning on leaving his family and giving them thousands of pounds

[@desmond3828]

When will you talk about the individual cells?

[@BK201DarkerThanBlack]

I thought this was a video about Tyrant Cells from Resident Evil at first. Given they are called T-cells in the game. Actual science is pretty enjoyable too. So I stayed anyway.

[@strasdove6214]

3'57: CD4 interact with MHC-II and CD8 interact with MHC-i !!!!!!!!!

[@yeetskeet5924]

3k views in 15 hours? Bro is unappreciated 😢

[@sasvideres2065]

My myositis loves this 😅

[@goldenquaarter]

Is that real?

[@ProfessorDaveExplains]

yes

[@anonimusgamingnation1979]

how i get acces to full series i am gonna have an exam on imunobiolgy and you help me a loot with your videos and i am stuck at adapative imunity and i know you have recorded all the videos just curios how to acces them if i become a membre i have acces to them ?

[@ProfessorDaveExplains]

i release them on a schedule, you'll get them all

[@skim4264]

Biorender?

[@ProfessorDaveExplains]

yeah it's dope

[@briwood6328]

Unrelated, but what do you think of that US military official saying there are non-human entities on earth he sounds crazy to me, just wondering what you think of him

[@zaconeil3709]

Why didn't they say 'aliens' if that's what they meant, as there are billions of 'non-human' entities on Earth. 'Entity' doesn't mean 'intelligent, thinking agent'

[@briwood6328]

@zaconeil3709 I know, but it was just odd how he was saying it

[@eliasmindreau1637]

Please free the new videos to all 😅

[@livingcodex9878]

おはようございます

[@donchristie420]

Good morning to you,as well

[@waelfadlallah8939]

​@@donchristie420classic duo

[@MBicknell]

Can ya do a vid on how i can stop going bald

[@briannunya2838]

Way to read a textbook

[@ProfessorDaveExplains]

It's a script written by an immunologist. Why so salty?

[@lyndonstachoski3897]

Nothing says "I'm deeply indoctrinated", than reading from a text book.

[@ProfessorDaveExplains]

Nothing says "I'm allergic to learning" like pretending textbook knowledge must be wrong because you say so.

[@ponponpatapon9670]

we should all read your text book-the Bible, or maybe Quran-instead, right?

[@galileog8945]

All of you conspiracy theorists seem unable to write a coherent sentence.

[@lyndonstachoski3897]

Do expermental injections ( mRNA ) increase/improve Immunity response?

[@ProfessorDaveExplains]

They're not experimental, and yes they prime the immune system for antibody generation, which is what vaccines do. Anything else, sweetie?

[@Nxck2440]

first

[@waelfadlallah8939]

Yes you are

[@donchristie420]

First to respond to first

[@WensleydaleBrown-wo5rg]

Oh boo, you did so many videos without me. 🫤 well what gives man, where's the Cornucopia?!?!