Forgot to say! I don’t work/cooperate/affiliated with any supplement company. ⭕Imagine having access to ALL the BEST supplement routines for longevity in 30 seconds... it’s possible-> WellnessMessiah.com/Longevity
Hi I said, collagen powder is what I give my parents - I don't recommend anything to anyone. Dose - needs to be customized to the situation and protein intake of the person, exercise routine, etc.@@consumer1073
@@WellnessMessiah The NOW brand Super Antioxidants supplement appears not to even be sold on Amazon or other online markets. Even the NOW website shows it as backordered. From my own experience, this usually means it’s being discontinued or reformulated.🙏 Any other suggestions perhaps?
🎯 Key Takeaways for quick navigation: 00:00 🌱 *Taurine shows strong potential in protecting against aging, with suggested doses increasing with age, but its effects on neurotransmitters warrant caution and individualized approaches.* 04:33 💊 *Niacin (B3) and NAD boosters like NMN and NR have potential in age-related health, with NMN showing promise in muscle health and exercise performance in older individuals.* 09:30 🌿 *Ashwagandha may help regulate cortisol levels, aiding stress management, particularly during periods of chronic stress or intense physical activity.* 11:50 💪 *ALCAR (Acetyl-L-Carnitine) supports muscle health by aiding fat metabolism and reducing reliance on glucose, potentially preserving muscle function with age.* 14:49 ☀️ *Vitamin D supplementation needs to be tailored based on individual conversion rates and genetic factors, with a recommended starting dose of 4,000 to 5,000 units per day.* 17:24 💊 *B vitamins can enhance energy and reduce anxiety but should be taken cautiously to avoid excess, with a preference for obtaining them from food sources or low-dose supplementation during fasting.* 19:27 🦴 *Glucosamine and chondroitin may support joint health and longevity, although further research is needed to fully understand their impact and optimal dosages.* 20:51 💊 *Glucosamine and chondroitin supplementation may be associated with reduced total mortality risk, particularly in higher doses, according to research findings.* 22:00 🎯 *Individuals over the age of 65 may benefit from tailored supplement regimens to mitigate the risk of accelerated aging, including hormonal support, antioxidant defense, and enhanced protein intake.* 23:09 🔄 *Cycling DHEA cream usage and integrating antioxidants like quercetin may help support hormonal balance and protect against oxidative damage, particularly in individuals over 65.* 26:18 🍖 *Increased protein intake, particularly in powdered or collagen form, may be beneficial for individuals over 65 to compensate for reduced protein absorption and support soft tissue health.* Made with HARPA AI
Worthwhile to mention that D3 should always be taken with K2 and that they are both fat soluble (a ratio of 5000 IU D3 to 150-180 mcg K2 is commonly advocated, I cannot confirm if it is appropriate) not a bad idea to take small amounts of magnesium, zinc, calcium, copper and boron at the same time as this combo works for bone health (K2 is the superstar in this). Taurine is not a bad thing to take with NAC and Glycine as a thrice weekly detox as they tend to work well together (take at a different time to morning vitamins, I take at night), the actual amounts used should be 600mg to 1000mg each, if you are using more than that you may be putting yourself out of balance. The trio's effectiveness can be slightly boosted by taking with a very small amount of vitamin C and E, and a very weak B group supplement (mainly for the small B6 content) as these can help the effectiveness of the NAC, but B6 amount needed by the NAC would be less than 5mg (very dangerous to take too much B6 overall, do not rely on vitamin manufacturers to know safe dose as they make a lot of money off ALA sold to detox it).
Thanks for addressing those over 65. I have changed up my supplement routine since I hit retirement to target those aging issues. It has clearly made a difference.
many people know the longevity effect of taurine but they do not understand the mechanism. here it is: in the mitochondria there are two primary types of fuels to be burned: glucose and fatty acids. and there is a difference in ROS production between burning fat or glucose. if burning glucose, ROS production is going up. if you understand ROS then you understand, that it is very very damaging. sometimes the body needs it as a defense mechanism against a virus of bacteria or a cancer cell that is gone rouge. but of course ROS is damaging also organelles, cell walls etc. so, if ROS is not needed, it should be avoided. staying in fat burning mode is key for that. one factor - besides many other factors - is making sure that fat burning is running smoothly and fast enough. if it is too slow to produce enough ATP, the mitochondria is switching to glucose burning mode. what is making sure that fatty acids are oxidized ( =burned) fast enough? ==> the speed of the enzymes that are involved in that (krebs cycle etc.) is depending on the pH level of the surrounding. if the pH level is going down ( lower pH = more acidic ) then the fat burning enzymes are slowing down. this is a usual effect from a chemical reaction. the speed looks like an S-curve, or mathematically like a sigmiod-function. it this case this sigmoid function describes how fast the chemical reaction is. AN THIS IS WHERE TAURINE IS COMING IN: taurine is a pH buffer. that means it keeps the acidity from changing fast. and there is a chain of pH buffers from taurine in the mitochondria to carnosine in the cell to bicarbonate in the blood. in legal sports doping where the body should stay in fat burning in long endurance sport (cycling, running over many hours etc.) they supplement with sodium bicarbonate, beta-alanine (to make carnosine) and taurine to have enough of these pH buffers. so, now the anti aging mechanism should be clear. in one sentence, taurine optimizes fat burning which lowers ROS which is one cause of aging.
@@nikola_korneta Reactive Oxygen Species. it you eat a huge carb meal, the excess carbs get partially converted into fat. and then burned also as fat. it is not black and white. i don't care what you do, and i don't tell you what you have to do. i just explained the mechanism in the mitochondria. and people also eat fatty pork belly and eggs for thousands of years. so usually they didn't eat carbs only.
I agree with everything, the damage of glucose like you said, and I add and taurine does other things as well beside PH buffer against aging. It's quite remarkable...basically a "don't die" supplement.
🎯 Key Takeaways for quick navigation: 00:00 🌟 *Cutting-edge longevity updates:* - Taurine, NMN, ashwagandha, and stress customization impact aging defense. - Personal insights on dosage and effects of various supplements. - Focus on optimizing aging defense protocols for individuals over 65. 01:23 💡 *Taurine benefits and dosage:* - Taurine shows strong potential in protecting against aging. - Dosage recommendation: around 1 gram per decade of age. - Individual responses vary; experimentation and cautious approach advised. 04:48 🔄 *NMN insights and dosing:* - Limited data on NMN's lifespan extension effects in humans. - Focus on muscle benefits and exercise performance over 60. - Recommended dose: 1 gram daily; individual response and quality of life improvements matter. 09:45 🌿 *Ashwagandha's role in stress management:* - Ashwagandha's potential to reduce cortisol levels during high-stress periods. - Importance of balanced cortisol levels for longevity. - Personal experimentation and cautious approach recommended. 11:50 💪 *ALCAR for muscle health:* - ALCAR aids in burning fat and reducing dependence on sugar for energy. - Personal experience suggests preservation of muscle vitality and youthfulness. - Dosing adjustment to 500 milligrams twice a day for a conservative approach. 14:49 ☀️ *Vitamin D supplementation:* - Importance of understanding vitamin D activation and conversion in the body. - Recommendations for dosage based on individual testing and genetic factors. - Addressing concerns about vitamin D toxicity and optimizing blood levels for health benefits. 17:24 🅱️ *B vitamins and aging:* - Adequate B vitamin levels linked to increased longevity and vitality. - Caution against excessive B vitamin intake, which may increase mortality. - Timing of supplementation during fasting and dosage adjustments for optimal results. 19:27 🦴 *Glucosamine for joint health:* - Glucosamine and chondroitin as building blocks for joint and ligament repair. - Potential benefits for preventing joint damage and promoting longevity. - Limited data on mortality reduction associated with glucosamine and chondroitin use. 20:51 ⚕️ *Glucosamine and chondroitin intake linked to 70% lower mortality risk according to a study.* 22:00 🦴 *Modification of supplements for individuals over 65 aims to counteract "runaway aging" by customizing longevity protocols.* 23:09 🧴 *Hormonal support recommended for individuals over 65, including DHEA cream for hormone production.* 24:05 🧠 *Antioxidant support becomes more crucial after age 65 to protect brain, eyes, and ears from oxidative damage.* 26:18 🍖 *Protein absorption decreases with age, particularly after 65, leading to a recommendation for extra collagen intake to support soft tissues and antioxidant defense system.* Made with HARPA AI
I took ashwaganda for a long time, 3..4 days per week. I liked the effect on psychology and regulation of sex drive. However, and that's a big one: It caused inflammation of the liver, AST got as high as 40. When I took it off, all other things roughly the same, AST returned to 28 after 8 months. So, if you start taking it, observe your liver enzymes. In order to support the healing i ramped up the vitamin A, by food and by supplement
Thanks, good feedback. TBH I'm still researching it! Definitely has some anti-cortisol anti anxiety. It seems so far as "use to cover a hole" as needed supplement. I suspect it will reduce the side effects you mentioned. But - I'm not yet the expert on it quite yet. My current obsession is taurine...
@@airy252 I slipped into a quasi-chronic intake. Pills were around 400 mg powder. First I used it very occasionally, sh like every 2..3 weeks for 1..2 days. The suppression of cortisol allows the sex hormones to be produced. Better sleep, as its latin name particle suggest, was just another argument. Feeling then more balanced... Until i did a lab test for sth completely different. which exposed some intense stress for the liver. Some 15 years ago i tried another so-called adaptogen, rhodiola, but that quickly turned out to be very bad for deeper levels of psychology. At that time i made research grade cognitive tests (N=1), and i saw it did work and amazingly enhanced short term memory.
I've tried several brands of ashwa, and very large doses, and I have to say it's another typical "witch doctor" herb of the hundreds we've seen in the last fifty years.
Love your content Rimon! Can you comment on the latest data on Niacin's metabolites (4PY) being linked to heart risk and inflammation? Does this also impact NMN/NR users? A video on this would be very helpful! Thank you for all you do
Yes. In short - I wouldn't be worried about it if you're healthy - not having history of cardiovascular disease. and yes, it affect NMN and NR much more than niacin. You will have to give up all benefits of NAD boosting. Long: 1. The study explored metabolic associations linked to outcomes, specifically focusing on correlations with individuals with a history of heart disease, not healthy subjects. It characterized these individuals as "stable patients" who had experienced a heart attack or a cerebrovascular event more than three years prior. 2. A key finding was the identification of a genetic variation in a segment of the population that hinders the processing of a niacin byproduct. This genetic anomaly could potentially be a contributing factor to their initial development of vascular diseases. The research pinpointed a genetic variant (rs10496731) significantly associated with altered levels of certain metabolites, suggesting a link to niacin metabolism. 3. However, there's a critical oversight regarding niacin. The metabolite 4PY, implicated in the study, results from niacinamide, not niacin. Niacin must be converted to NAD, which then becomes niacinamide. Notably, NMN and NR, precursors to NAD, produce significantly more niacinamide (and consequently 4PY) than niacin does. This suggests that for individuals with the mentioned genetic variant, niacin might be preferable over NMN and NR. 4. The preliminary conclusion indicates a subset of the population may experience adverse effects from NAD boosting, unable to efficiently eliminate certain byproducts, thus paying a "price" for increased NAD levels. 5. Additionally, the research underscores the potential benefits of TMG supplementation. TMG might not only mitigate heart disease risk by lowering homocysteine levels but also by reducing other harmful metabolites produced from niacinamide, which can be toxic in large quantities. 6. While the general use of niacin doesn't raise concerns, it's crucial to investigate the specific byproducts of NAD+ enhancement further. Are there methods to minimize these byproducts? Do certain individuals with genetic predispositions benefit less from NAD+ boosting compared to the broader population? These questions highlight the need for more nuanced studies and precise language in research findings, rather than attributing outcomes to niacin indiscriminately. Moreover, the study hints at potential kidney function implications, as methyl-niacinamide is typically expelled through the kidneys, not converted into 2PY and 4PY. This complexity is characteristic of metabolic studies, where determining causality can be challenging. It's possible that underlying detoxification issues could contribute to secondary cardiac events.
@WellnessMessiah Thank you! Very interesting answer. I do take TMG so that is reassuring. Leave it to you to find an oversight with respect to Niacin perhaps being preferred to NMN/NR! Great stuff. I will keep watching your videos for more as this issue develops!
Some evidence that b6, b9 and b12 can build up in unexpected places, if it remained in the blood, absolutely yes it would be excreted but that doesn't always seem to be the case depending on amounts and the body's demand for them. Also very important to take the natural versions rather than the synthetic ie B6 version s/be P5P, and the methyl versions of B9 and B12 s/be taken so you are not dependant on your internal organs to convert them into the useable forms. B vitamins tend to need each other so taking a high amount of 1 without the others may have unpredictable affects... B6 is one to watch out for as amounts in supplements are often dangerous when taken long term (25-50 mg P5P is possibly the bodies tolerable upper limit from supplements, might be as little as 12-15mg if taking the synthetic form pyridoxine hydrochloride, however frankly this depends on many factors such as body weight and what other vitamins and minerals you take as supplements / diet more generally / medical conditions)
I think it depends on the type of B12, you should never ever high dose (or take at all) cyanocobalmine as it contains cyanide. Despite the amount is considered very safe, its not when you megadose as cyanide is very tough to get out of your body system. In other words, you give yourself a very slow cyanide poisoning if you high dose this type of B12. And you may know that cyanide is also barely tracable until you turn blue or get the typical almond like smell. But before that happens you probably died already. It can cause all kinds of weird health issues no one can explain before that. I take B12 as methylcobalmine as mouth spray, it has like 25000% RDA, but I only take 1 spray instead of the 4 recommended as daily dose. It doesnt feel right for me to dose this high, injections go up to even 125000% rda, but they say your body poorly absorbs B12 and you need these high doses to combat deficiency in order to absorb what you need to fix it in a fast rate. Those highdosed supplements aim for garanteed 100% absorbed RDA.
Opinion: Yes, protein absorption may drop a bit with age, but exercising is best way to prevent muscle loss aside from many other benefits as we age. Get a scale which measures lean muscle mass and body fat and start tracking. If you start loosing lean mass on a good diet and exercise then consider a little more protein in the form of higher protein real food, Things like nuts and beans. Avoid the powders.
Congratulations, Rimon. I haven't been here for a while and on watching this, I observed with joy, the astronomical growth in your number of subscribers. I used to feel bad when your numbers were still low because I never quite understood why such an informative channel would be under subscribed. The only way is up for you now. I hope your wife continues to make a good recovery. Best wishes.
Hey. Thanks again for the outstanding content. 😊 I've probably missed this somewhere but do you have any thoughts on a reputable glucosamine/chondroitin brand? Prayers for your wife's ongoing recovery (and the continued success of your channel 😉) 😊
Re: Taurine. Recommend getting an amino acid profile which includes taurine. Then module diet, exercise and supplementation over time to get to high end of reference range. Makes no sense to just gobble many grams a day without testing. I'm 69 yo and have levels of a 30 to 40 yo according to data in studies and I only use 500 mg/d which I've taken for about 10 years for other reasons (vascular). Now taking 1 gram a day and will retest again soon. Same idea with Vitamin D (I take 5000 IU /d), Omega 3 index, test and modulate diet and supplementation and as needed. My D3 level is in 40 to 50 ng/ml range. Omega 3 index 7.8%, almost ideal ( i take about 600 mg of EPA and DHA, eat flaxseed and nuts and a little fish). Test when testing is available.
@@PedroGonzalez-me1qb Taurine is an amino acid so you can get level as part of an amino acid blood test. Life Extension has a comprehensive profile for around $130. But you can google for other options.
Good video! Thanks for dividing supplement analysis into age groups (65). This is important for some supplements. I'm surprised you didn't do that for NMN, though. NMN is mostly used by older people to restore NAD levels to closer to youthful levels. I don't know if niacin can do as good of a job in older people. It is a good example of a supplement that doesn't make sense to use when younger, especially since it's expensive, but can be justified in older people.
C'est peut être utile pour des gens qui ont traversés de grosses périodes difficile où ils se sont abîmés avant l'heure non ? Une cure pour essayer de se régénérer Les niveaux de NAD dans ces cas là pour se réparer un peu, une bonne idée ou pas ??
@@michaelcaeyman9927from Southern Colorado Rockies USA I'd say great Idea who determines adequate damage ,no one but ourselves,the Dr. Here seems as though he's experimented on him self and parents and found a great base for us to build from Peace
Good stuff...appreciate the info on taking care of our older parents. My mother so far has been fairly receptive to my suggestions. She's on medications so I don't want to overload her with supplements so suggestions such as bone brother are helpful. Being 65 myself..this stuff is important to me as well. Your work is appreciated.
Nice meeting you here. I have passion for 65+, it doesn't work well with youtube. I speak some about it in my updated supplement routine, what I do with my parents: wellnessmessiah.com/app
Couple of things, Taurine taken on the empty stomach in the morning will stimulate your gllbladder and improve bile flow. This will help to prevent stones from forming also a good easy way to jump start your day. Second, vitamin E should be in tocotrienol form - this is important. I also add CaAKG and some other amino acids before workout, and creatine. Creatine not just gor musvle growth but for stress and mental health actually which was surprising to me…different doses for men and women because of the way it’s processed, gender specific things…also a quick note on micro-dosing melatonin after 40. A few more things I had really good success with if it’s interesting, I can write later! 😊👍
Interesting. Can you let me know the study/ paper that suggests taurine benefit for gall bladder benefit? Just name would be enough, since YT poofs most comments with links
I take magnesium citrate in the morning and take magnesium taurate just before bed. Taurate is the salt of taurine, so the magnesium/taurine combo is great for many reasons, including healthy sleep. I also munch on some pumpkin seeds sometimes before bed because those are a good source of magnesium.
I too divide my magnesium need in different types of magnesium. I take magnesium taurate in the morning to also aid my morning intake of vit D (3000IU) and magtein (magnesium threonate) in the evening with my 2000IU vit D. During the day I take magnesium in my electrolyte tab due to me being chef I sweat a lot and need to replenish in plenty. I think this magnesium is glycinate, only the other two I buy specific. I like to spread doses even if it says I only need to take once a day, if possible I take half or try twice or three times a day. Shouldnt need to overdose unless known deficiency like I have for vit D, magnesium and probably B12.
@@AnnaMaria-zm8cv I take capsules daily of either wild caught cod liver oil or salmon oil for vitamin D, besides the sunshine. I get my omega 3s that way, too. Pumpkin seeds are also very high in magnesium. A handful before bed can help with sleep.
Thank you for providing all this good information Simon. I’m interested in exploring taurine for its heart and vascular positive effects. More specifically for mom who is 90 and other than for AFIB and arthritis she is pretty healthy, the biggest issue I find is that whenever I bring the supplements topic up to her doctors they say not to take them. She has AFIB, takes blood thinners and, deuretics, and BP medications, how could she safely start introducing taurine with testing to verify that we are getting all the full Benefits wo getting into trouble?
Lifted weights till now, ( 50 years ,l 1 gram nmn has helped rotator cuff pain shoulder pain and the lack of pain has helped reverse gradually loss of strength
Interested to find out if you’ve heard Chris Masterjohn’s warning of NMN supplementation leading to excessive filling of the niacin pool and epethial damage to vascularature. I need to try and read his post again because he’s incredibly technical. But he cautions against high dose NMN.
I read about the B 12 problem. I have a question though. Did they they make a distinction between those who supplemented methylcobalamine and those who supplemented with cyanocobalamine? It's my bet there is a difference.
I took 10,000 IU’s of quality Vit D throughout the pandemic. Never got sick BUT the skin on my hands and feet literally started peeling off because of Vit D toxicity. Taking powder form as opposed to natural sunlight will obviously be Absorbed differently. Like he said starting at 4000 IU’s should be fine.
I live in Hawaii and we all live in our bathing suits getting lots of sunlight on our skin. It’s almost impossible to get vitamin d levels higher than 50 naturally from the sun. Only supplements can cause it to go higher.
It's interesting. It could be that supplemental vitamin D circumnavigate some skin regulation . On the other side, in the video I spoke about 70,000 years ago - people going with no clothes all day long. Large areas are back, chest.. these are still hidden vs the past.
HI Rimon: i take niacin, first few days I got the flush but soon developed tolerance to it no longer have any flush with it, I suggest start with a low dose for a week and gradually increase , I take anywhere from 500 to 1500 mg Niacin flush per day, both for Mitochondria health and lipid profile.
I need metholated B Vitamins. Other wise on deficiency. I have a metholated issue. The same with NAC I'm low on glutathione. So I have to take liposomal Glutathione
I have been taking Taurine for several years and do notice when I go a few days off of it. Like you I am not sold on the NMN. Ashwaganda is a no-no for me it makes me feel very weird. The supplements my body clearly “misses” when not taking them are: Taurine, Magnesium and Creatine.
Huge Thank-you ! All Great Info. ! One Full Body/Brain , Natural Supplement that You Did Not Mention, I take Daily as well as My Mother in her Late 80's Is Creatine Monohydrate ! Your body produces Naturally but as We Age it is Imperative for Good Health and Longevity ! Cheers !
Yep, I'm 75 and take 5 grams a day along with my whey protein powder. I also take 3 grams hmb to ward off muscle wasting. He also didn't mention NAC and glycine.
Thanks for this. You’ve convinced me to start taking Taurine for the first time. I didn’t fully understand when you take it and why and how to stop it interfering with sleep
The comment about exercise and joints is valid. However not all exercise is equal on our joints. I swim & often use training aids like paddles and flippers. Increasing the load on my muscles but not joints. Win win
There's a lot of hype towards NMN and NR. Probably it's due to commercial interests. Niacin has been on the market for a long time and isn't a good business for labs
I can not easily mix Taurine with water. It floats on the top, makes a cork, very light, doesn't want to dissolve or mix in any way. I take capsules therefore.
For CVD prevention, I’m taking 100mg of Niacin along with bergamot. I used to wash my supplements down with a protein smoothie that included banana, but I replaced the banana with apple because there’s a compound in banana that blocks the benefits of polyphenols found in berries and bergamot.
Great information, thank you! I was researching into the NOW brand super antioxidants, and it seems that the bottle used to be $17, then the price was increased to almost $40, which does not really matter because it is not currently available; so I am thinking I may try to get quercetin on its own, and less you have a different suggestion.
Hi yeah $40 is too much. if you find 50mg quercetin that will do it... it's super strong be careful with extra doses. I explain more on quercetin doses and uses in this report: www.wellnessmessiah.com/gift
Are you at all concerned about the recent study showing cardiovascular inflammation from excess niacin intake? The metabolite of concern will likely be impacted by NMN as well. What are your thoughts? Thanks!
No, I looked into the study, I wouldn't worry about it. Here's why: 1. The study was metabolic association with outcome. That is, an association with sick people. A double weakness. Not a cause, but an association. Not healthy people, but people with a history of heart disease. But a heart attack or a cerebral event more than 3 years ago. Therefore, "stable patients". 2. They found that there is a genetic defect in part of the population that does not resolve from a byproduct of niacin. In fact, it is very possible that this genetic defect is the reason they initially developed vascular disease. "suggested that niacin metabolism was associated. Phenome-wide association analysis of the genetic variant rs10496731, which was significantly associated with both 2PY and 4PY levels,” 3. And here's the highlight. The researchers linked this to niacin. In my opinion, this is a serious mistake. The byproduct 4PY comes as a result of niacinamide. Not from niacin at all. That is, niacin needs to be converted to NAD which will turn into niacinamide. It's important to emphasize, NMN and NR produce much more niacinamide and therefore 4PY than niacin. This is actually a case for niacin and less for NR and NMN for people with this genetic defect. 4. The main conclusion currently is that there may be a certain group in the population paying a "price" for NAD boosting. They will get more NAD, but some will not be able to properly get rid of its byproducts. 5. And the second conclusion is that this strengthens the case for taking TMG. That is, it's very possible that TMG protects from heart diseases not only because it lowers homocysteine, but reduces other toxic metabolites we're not aware of from niacinamide (which is known to be toxic in high amounts... I mentioned that in my videos) 6. I wouldn't worry about niacin in general, but I would thoroughly examine the certain byproducts of NAD+ boosting. Maybe there are things we can do to reduce them? Maybe there are people with a genetic tendency who don't derive the value from them that the rest of the population does? These are important questions. But we need association studies and the use of precise terminology and not to lay the blame on "niacin". It could be that these metabolites also indicate kidney insufficiency. methyl-niacinamide would normally be excreted via the kidney. Not becoming 2PY and 4PY. That's what happens with metabolic studies, you never know what caused what... I wouldn't rule out difunctional detoxification underlying secondary cardiac event here
Wow, this is incredible research. I know many in our community are asking the question that I did. However, I don't think anyone has answered it as well as you did. I know it's tough to find the time, but you may want to do a short video on this as it's gold. Such important information and so well-researched. Thanks for all that you do!! And God Bless you and your wife. Wishing her a good recovery.@@WellnessMessiah
I am not sure where the idea that B vitamins are in highest concentrations in vegetables. I always thought that highest concentration and dosages of b vitamins you get from liver and other organs and meat.
Thank you for sharing your insights, informative and much appreciated. I may be wrong, but you may want to double check the units Vit D (40-70 nmol/L ?). I think you meant ng/mL (?)
Hi Rimon, Happy to see you again. Very informative another podcast. Most appreciated. But lately after eating my first b/ fast my blood pressure is dropping. Normally I was on OMAD. But I’m afraid so much from low pressure so divided my meal into two, one is B/ fast am & dinner is latest 3 pm. If I eat protein I'm ok if not it drops to 80 / 59 or 85/59 Because of carbs, rare but & 102/ 56 or 90/59 mostly. something to do with my cortisol levels, they are low But is there a relationship with the molecules, I don't know🤷♀️ Once I went to a private clinic but couldn't find time to talk with the doctor, I had a flight to catch so wanted doc to give me the results on the phone but she refused it😢This was years ago. Also Next week they will monitor my BP 😛. Lack of protein caused some of these problems but now started to eat Turkey meat etc♥️ also began to take 500 of metamorfine. ( bought from abroad) Listen to our valuable Scientist Prof David Sinclair🙏 Thank you, Rimon most trustful and helpful videos., I keep on praying for your lovely wife🙏🌹♥️ God Bless you & your wife🙏🙏
@@babyreps365 I don't know. Over 100 dollars, maybe over 200 dollars.To be 75 years old and feel like 30 is worth it. Here's a tip. If you want to increase muscle strength and size (without exercise as I am a lazy bum) take BCAA and HMB. Branch Chain amino acids are anabolic for muscle while HMB, a metabolite normally produced from BCAA but in insufficient quantity is an anti-catabolite for muscle. For a specific muscle contract it at least 75 percent maximum and keep it that way for at least 30 seconds (I got that out of a physiology textbook many years ago.) And of course you must eat protein. Other supplements help too.
@@evarkf I really should update my list. I don't think my doctor ever heard of most of them. I asked her about Honokiol and she never heard of it. It comes from Magnolia bark. I'll soon be ordering Urolithin A and PQQ. You couldn't possible get enough of the things I take in your diet every day. BTW the best source of PQQ is dark chocolate, 90 percent cocoa. I learn something new every day. I have many interests and extending my lifespan and healthspan is just one of them. To be honest some of them do scare me and some of them have resulted in blood tests out of the normal range and had to be terminated.
Thank you so much for the Great content, I trust you more than any one ,could you please share which brand of vitamin b3 ( niacin) and collagen do you use ?! Are you recommending whey protein for people over 55 or 60 it has all the amino acids especially for those who don't eat red meat alot maybe once a week?! Greatly appreciated 🙏❤😊
@@WellnessMessiah please clarify-- have read that you should not take taurine and glycine at the same time because they compete with each other for absorption
Makes little sense on the surface... animals with low rate live much longer, centenarians have low body temp (affects metabolic rate), etc. Never looked into Ray work
I have never heard any expert suggest that NMN prevents cancer. I have experienced numerous benefits from NMN which I have been taking for five years and feel 10-20 years younger than my 70+ years.
Hi as I said - what matters is the end result. If NMN makes you happy, gives you what you want - nothing could be that.. not even the best studies. Results always win. Lots of love
Maybe it's the afternoon when you want to exercise, and not take a nap. I have taken taurine straight. But I had to take it separate from meals. Currently I take Magnesium Taurate with meals, twice a day.
Are you aware that tocotrienol is 50 times more protective of fat oxidation than tocopherol? I learned this from an hour long interview on Modern HealthSpan about six months ago. I apologize for not knowing the doctor's name, but he spend most of his life studying tocotrienol. He also said that tocopherol diminishes the effect of tocotrienol, so they should not be taken together. For those who have had radiation treatment, I use tocotrienol together with pentoxyfilline to reduce fibrosis from radiation (see the papers of Dr. Sylvie Delanian for dosages.) This combination, although I used tocopherol until recently, has kept my throat open for decades. It is common for fibrosis to keep growing and fill the throat so that a feeding tube is required. Many ENT doctors know about this cocktail now, but not about tocotrienol.
Also, for fat soluble vitamins like D, K, E, and A, it's best absorbed in the presence of fat from food. Maybe eat a bit first, then take them. For myself, it made the difference in absorption .
Question. Although as older individuals we absorb less of the protein we eat- it will still all count as calories? So we have to eat more calories to get the same amount of protein as when we were young?
Is Taurine the same as L-Taurine? Some Internet sites say there’s a distinct difference. I read something about Taurine having a different chiral configuration from L-Taurine, which makes all the difference in the world as to if and how the body uses it properly. I have not seen L-Taurine at stores lately. I have Taurine at home now wonder if I’m wasting my time taking it?
Hi technically, I have already created such a video. These 3 supplements super important for young people: ua-cam.com/video/Xz9yJq5SPvA/v-deo.htmlsi=TMJTSWC2Fh6c_ohy
Thank you so much Rimon for this video. I am a 70 yrs. old African American female in GOOD general health but do not feel the energy I used to since turning 70. I am on bio-Identical hormone replacement cream (16 yrs. now)--not due to any disease. It was elective for me as a way to manage aging. Is it OK for me to add DHEA cream? Also do I understand correctly that I can try either Niacin OR NMN? I don't need both? Thank you.
Hi I think it's fine. But timing matters a lot. I would take e.g. 500 mg NMN in the morning and after 8 hour 50mg niacin and again after 7-8 hours. Feeding NAD enzymes all day long. It's probably would be my future routine :)
yes, I drink both coffee and green tea - all kinds. The best is - no sugar, no milk, both green tea and coffee (away from sleep) are good - not personal recommendation ) e.g people who have high BP should be careful, etc - just what I do.
NMN has incredibly improved my eczema on my hands which I have year round. I started NMN last week. Also, I was having crazy inflammation in my body which led to incredible hair loss and NMN has helped my hair to stop falling out. I take it with TMG. So far it’s a miracle supplement. PS I’m 31 years old.
surprised on the Vitamin D info. I've been taking 5k iu of K2 & D3 (cholocalciferal) and I get my Vitamin D measured since I've got osteoporosis. My last measure showed an increase in my bone density! I take a lot of supplements, but I thought it would have been due to the Vitamin D or NMN(?).
I also avoid all prescriptions if I can. I even turned down statins and I'm using nattokinase instead. Some study actually found it far more effective at removal of plaque. I don't care for nmn too pricey and I didn't notice any benefits personally.
![These Molecules Reversed Aging by... YEARS! [TRIIM Study Explained - Study 216]](http://i.ytimg.com/vi/rVoxfABoHh4/mqdefault.jpg)
Forgot to say! I don’t work/cooperate/affiliated with any supplement company.
⭕Imagine having access to ALL the BEST supplement routines for longevity in 30 seconds...
it’s possible-> WellnessMessiah.com/Longevity
you have a pencilneck
what protein do you recommend for 65+ parents and in what dose?
Hi I said, collagen powder is what I give my parents - I don't recommend anything to anyone. Dose - needs to be customized to the situation and protein intake of the person, exercise routine, etc.@@consumer1073
Is there any specific place/lab you recommend for getting NAD levels checked? Thanks
@@WellnessMessiah The NOW brand Super Antioxidants supplement appears not to even be sold on Amazon or other online markets. Even the NOW website shows it as backordered. From my own experience, this usually means it’s being discontinued or reformulated.🙏
Any other suggestions perhaps?
🎯 Key Takeaways for quick navigation:
00:00 🌱 *Taurine shows strong potential in protecting against aging, with suggested doses increasing with age, but its effects on neurotransmitters warrant caution and individualized approaches.*
04:33 💊 *Niacin (B3) and NAD boosters like NMN and NR have potential in age-related health, with NMN showing promise in muscle health and exercise performance in older individuals.*
09:30 🌿 *Ashwagandha may help regulate cortisol levels, aiding stress management, particularly during periods of chronic stress or intense physical activity.*
11:50 💪 *ALCAR (Acetyl-L-Carnitine) supports muscle health by aiding fat metabolism and reducing reliance on glucose, potentially preserving muscle function with age.*
14:49 ☀️ *Vitamin D supplementation needs to be tailored based on individual conversion rates and genetic factors, with a recommended starting dose of 4,000 to 5,000 units per day.*
17:24 💊 *B vitamins can enhance energy and reduce anxiety but should be taken cautiously to avoid excess, with a preference for obtaining them from food sources or low-dose supplementation during fasting.*
19:27 🦴 *Glucosamine and chondroitin may support joint health and longevity, although further research is needed to fully understand their impact and optimal dosages.*
20:51 💊 *Glucosamine and chondroitin supplementation may be associated with reduced total mortality risk, particularly in higher doses, according to research findings.*
22:00 🎯 *Individuals over the age of 65 may benefit from tailored supplement regimens to mitigate the risk of accelerated aging, including hormonal support, antioxidant defense, and enhanced protein intake.*
23:09 🔄 *Cycling DHEA cream usage and integrating antioxidants like quercetin may help support hormonal balance and protect against oxidative damage, particularly in individuals over 65.*
26:18 🍖 *Increased protein intake, particularly in powdered or collagen form, may be beneficial for individuals over 65 to compensate for reduced protein absorption and support soft tissue health.*
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Thank you.
Worthwhile to mention that D3 should always be taken with K2 and that they are both fat soluble (a ratio of 5000 IU D3 to 150-180 mcg K2 is commonly advocated, I cannot confirm if it is appropriate) not a bad idea to take small amounts of magnesium, zinc, calcium, copper and boron at the same time as this combo works for bone health (K2 is the superstar in this). Taurine is not a bad thing to take with NAC and Glycine as a thrice weekly detox as they tend to work well together (take at a different time to morning vitamins, I take at night), the actual amounts used should be 600mg to 1000mg each, if you are using more than that you may be putting yourself out of balance. The trio's effectiveness can be slightly boosted by taking with a very small amount of vitamin C and E, and a very weak B group supplement (mainly for the small B6 content) as these can help the effectiveness of the NAC, but B6 amount needed by the NAC would be less than 5mg (very dangerous to take too much B6 overall, do not rely on vitamin manufacturers to know safe dose as they make a lot of money off ALA sold to detox it).
Thank you for all you do🙏🏻
Thank you ❤
Thank you for the extra knowledge and summary.
I'm 92 with no medical problems or prescriptions, but my vitamins are getting out of hand. So many to take!
I’d marry you 😅
Blessing sir ❤
I’m with you! I take about 50 supplements a day in 3 divided doses: in the morning, with dinner and before bedtime.
😂 I'd take more but bang for the buck and no finances
@ChuckStaley There are reputable companies that can do testing to know exactly what and how much of each supplement your individual body needs.
You are joking of course. Good one
Thanks for addressing those over 65. I have changed up my supplement routine since I hit retirement to target those aging issues. It has clearly made a difference.
Will review it and see, almost 63
Thank you for thinking of our age people.
Great help.
Many Thanks.
Wish you & your wife a Healthy Happy New Year🙏🌹🙏
many people know the longevity effect of taurine but they do not understand the mechanism.
here it is:
in the mitochondria there are two primary types of fuels to be burned: glucose and fatty acids.
and there is a difference in ROS production between burning fat or glucose. if burning glucose, ROS production is going up. if you understand ROS then you understand, that it is very very damaging. sometimes the body needs it as a defense mechanism against a virus of bacteria or a cancer cell that is gone rouge.
but of course ROS is damaging also organelles, cell walls etc.
so, if ROS is not needed, it should be avoided. staying in fat burning mode is key for that.
one factor - besides many other factors - is making sure that fat burning is running smoothly and fast enough. if it is too slow to produce enough ATP, the mitochondria is switching to glucose burning mode.
what is making sure that fatty acids are oxidized ( =burned) fast enough?
==> the speed of the enzymes that are involved in that (krebs cycle etc.) is depending on the pH level of the surrounding. if the pH level is going down ( lower pH = more acidic ) then the fat burning enzymes are slowing down. this is a usual effect from a chemical reaction. the speed looks like an S-curve, or mathematically like a sigmiod-function.
it this case this sigmoid function describes how fast the chemical reaction is.
AN THIS IS WHERE TAURINE IS COMING IN:
taurine is a pH buffer. that means it keeps the acidity from changing fast. and there is a chain of pH buffers from taurine in the mitochondria to carnosine in the cell to bicarbonate in the blood.
in legal sports doping where the body should stay in fat burning in long endurance sport (cycling, running over many hours etc.) they supplement with sodium bicarbonate, beta-alanine (to make carnosine) and taurine to have enough of these pH buffers.
so, now the anti aging mechanism should be clear. in one sentence, taurine optimizes fat burning which lowers ROS which is one cause of aging.
What's ROS? And what, to live longer we need to eat keto? Will never believe that. People lived on carbs for thousands of years.
@@nikola_korneta Reactive Oxygen Species. it you eat a huge carb meal, the excess carbs get partially converted into fat. and then burned also as fat. it is not black and white. i don't care what you do, and i don't tell you what you have to do. i just explained the mechanism in the mitochondria. and people also eat fatty pork belly and eggs for thousands of years. so usually they didn't eat carbs only.
I agree with everything, the damage of glucose like you said, and I add and taurine does other things as well beside PH buffer against aging. It's quite remarkable...basically a "don't die" supplement.
Yes but I not think we need between 33-60g as he says?
@@nikola_kornetano people have not lived on carbs for thousands of years! What a ridiculous comment !
Vit D3 with K2
I find your comments some of the best on the web. You deliver things directly.
🎯 Key Takeaways for quick navigation:
00:00 🌟 *Cutting-edge longevity updates:*
- Taurine, NMN, ashwagandha, and stress customization impact aging defense.
- Personal insights on dosage and effects of various supplements.
- Focus on optimizing aging defense protocols for individuals over 65.
01:23 💡 *Taurine benefits and dosage:*
- Taurine shows strong potential in protecting against aging.
- Dosage recommendation: around 1 gram per decade of age.
- Individual responses vary; experimentation and cautious approach advised.
04:48 🔄 *NMN insights and dosing:*
- Limited data on NMN's lifespan extension effects in humans.
- Focus on muscle benefits and exercise performance over 60.
- Recommended dose: 1 gram daily; individual response and quality of life improvements matter.
09:45 🌿 *Ashwagandha's role in stress management:*
- Ashwagandha's potential to reduce cortisol levels during high-stress periods.
- Importance of balanced cortisol levels for longevity.
- Personal experimentation and cautious approach recommended.
11:50 💪 *ALCAR for muscle health:*
- ALCAR aids in burning fat and reducing dependence on sugar for energy.
- Personal experience suggests preservation of muscle vitality and youthfulness.
- Dosing adjustment to 500 milligrams twice a day for a conservative approach.
14:49 ☀️ *Vitamin D supplementation:*
- Importance of understanding vitamin D activation and conversion in the body.
- Recommendations for dosage based on individual testing and genetic factors.
- Addressing concerns about vitamin D toxicity and optimizing blood levels for health benefits.
17:24 🅱️ *B vitamins and aging:*
- Adequate B vitamin levels linked to increased longevity and vitality.
- Caution against excessive B vitamin intake, which may increase mortality.
- Timing of supplementation during fasting and dosage adjustments for optimal results.
19:27 🦴 *Glucosamine for joint health:*
- Glucosamine and chondroitin as building blocks for joint and ligament repair.
- Potential benefits for preventing joint damage and promoting longevity.
- Limited data on mortality reduction associated with glucosamine and chondroitin use.
20:51 ⚕️ *Glucosamine and chondroitin intake linked to 70% lower mortality risk according to a study.*
22:00 🦴 *Modification of supplements for individuals over 65 aims to counteract "runaway aging" by customizing longevity protocols.*
23:09 🧴 *Hormonal support recommended for individuals over 65, including DHEA cream for hormone production.*
24:05 🧠 *Antioxidant support becomes more crucial after age 65 to protect brain, eyes, and ears from oxidative damage.*
26:18 🍖 *Protein absorption decreases with age, particularly after 65, leading to a recommendation for extra collagen intake to support soft tissues and antioxidant defense system.*
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I took ashwaganda for a long time, 3..4 days per week. I liked the effect on psychology and regulation of sex drive. However, and that's a big one: It caused inflammation of the liver, AST got as high as 40. When I took it off, all other things roughly the same, AST returned to 28 after 8 months. So, if you start taking it, observe your liver enzymes.
In order to support the healing i ramped up the vitamin A, by food and by supplement
How much dose did u take?
@gaston. Liver enzymes, also it messes with thyroid. I suggest being very careful with plant extracts
Thanks, good feedback.
TBH I'm still researching it! Definitely has some anti-cortisol anti anxiety.
It seems so far as "use to cover a hole" as needed supplement. I suspect it will reduce the side effects you mentioned. But - I'm not yet the expert on it quite yet. My current obsession is taurine...
@@airy252 I slipped into a quasi-chronic intake. Pills were around 400 mg powder. First I used it very occasionally, sh like every 2..3 weeks for 1..2 days.
The suppression of cortisol allows the sex hormones to be produced. Better sleep, as its latin name particle suggest, was just another argument. Feeling then more balanced...
Until i did a lab test for sth completely different. which exposed some intense stress for the liver.
Some 15 years ago i tried another so-called adaptogen, rhodiola, but that quickly turned out to be very bad for deeper levels of psychology. At that time i made research grade cognitive tests (N=1), and i saw it did work and amazingly enhanced short term memory.
I've tried several brands of ashwa, and very large doses, and I have to say it's another typical "witch doctor" herb of the hundreds we've seen in the last fifty years.
תודה!
תודה רבה
Love your content Rimon! Can you comment on the latest data on Niacin's metabolites (4PY) being linked to heart risk and inflammation? Does this also impact NMN/NR users? A video on this would be very helpful! Thank you for all you do
Yes. In short - I wouldn't be worried about it if you're healthy - not having history of cardiovascular disease. and yes, it affect NMN and NR much more than niacin. You will have to give up all benefits of NAD boosting.
Long:
1. The study explored metabolic associations linked to outcomes, specifically focusing on correlations with individuals with a history of heart disease, not healthy subjects. It characterized these individuals as "stable patients" who had experienced a heart attack or a cerebrovascular event more than three years prior.
2. A key finding was the identification of a genetic variation in a segment of the population that hinders the processing of a niacin byproduct. This genetic anomaly could potentially be a contributing factor to their initial development of vascular diseases. The research pinpointed a genetic variant (rs10496731) significantly associated with altered levels of certain metabolites, suggesting a link to niacin metabolism.
3. However, there's a critical oversight regarding niacin. The metabolite 4PY, implicated in the study, results from niacinamide, not niacin. Niacin must be converted to NAD, which then becomes niacinamide. Notably, NMN and NR, precursors to NAD, produce significantly more niacinamide (and consequently 4PY) than niacin does. This suggests that for individuals with the mentioned genetic variant, niacin might be preferable over NMN and NR.
4. The preliminary conclusion indicates a subset of the population may experience adverse effects from NAD boosting, unable to efficiently eliminate certain byproducts, thus paying a "price" for increased NAD levels.
5. Additionally, the research underscores the potential benefits of TMG supplementation. TMG might not only mitigate heart disease risk by lowering homocysteine levels but also by reducing other harmful metabolites produced from niacinamide, which can be toxic in large quantities.
6. While the general use of niacin doesn't raise concerns, it's crucial to investigate the specific byproducts of NAD+ enhancement further. Are there methods to minimize these byproducts? Do certain individuals with genetic predispositions benefit less from NAD+ boosting compared to the broader population?
These questions highlight the need for more nuanced studies and precise language in research findings, rather than attributing outcomes to niacin indiscriminately. Moreover, the study hints at potential kidney function implications, as methyl-niacinamide is typically expelled through the kidneys, not converted into 2PY and 4PY. This complexity is characteristic of metabolic studies, where determining causality can be challenging. It's possible that underlying detoxification issues could contribute to secondary cardiac events.
@WellnessMessiah Thank you! Very interesting answer. I do take TMG so that is reassuring. Leave it to you to find an oversight with respect to Niacin perhaps being preferred to NMN/NR! Great stuff. I will keep watching your videos for more as this issue develops!
Thanks for your opinions and research on all of that. I hope that your wife continues to improve.
I thought B12, like other B vitamins, was water soluble. Therefore, any excess would be harmlessly excreted. Is that not so?
no so simple !
I thought that too. What's the harm? I was surprised like you
Some evidence that b6, b9 and b12 can build up in unexpected places, if it remained in the blood, absolutely yes it would be excreted but that doesn't always seem to be the case depending on amounts and the body's demand for them. Also very important to take the natural versions rather than the synthetic ie B6 version s/be P5P, and the methyl versions of B9 and B12 s/be taken so you are not dependant on your internal organs to convert them into the useable forms. B vitamins tend to need each other so taking a high amount of 1 without the others may have unpredictable affects... B6 is one to watch out for as amounts in supplements are often dangerous when taken long term (25-50 mg P5P is possibly the bodies tolerable upper limit from supplements, might be as little as 12-15mg if taking the synthetic form pyridoxine hydrochloride, however frankly this depends on many factors such as body weight and what other vitamins and minerals you take as supplements / diet more generally / medical conditions)
I think it depends on the type of B12, you should never ever high dose (or take at all) cyanocobalmine as it contains cyanide. Despite the amount is considered very safe, its not when you megadose as cyanide is very tough to get out of your body system. In other words, you give yourself a very slow cyanide poisoning if you high dose this type of B12. And you may know that cyanide is also barely tracable until you turn blue or get the typical almond like smell. But before that happens you probably died already. It can cause all kinds of weird health issues no one can explain before that. I take B12 as methylcobalmine as mouth spray, it has like 25000% RDA, but I only take 1 spray instead of the 4 recommended as daily dose. It doesnt feel right for me to dose this high, injections go up to even 125000% rda, but they say your body poorly absorbs B12 and you need these high doses to combat deficiency in order to absorb what you need to fix it in a fast rate. Those highdosed supplements aim for garanteed 100% absorbed RDA.
Great advice Rimon and very much appreciated here in China. Thank you
Great to meet your here, lot of love
On the next show would you please talk about Graviola and Ginko Thank You 💖
Hi Julie ask in our group:
www.skool.com/longevity-hackers
appreciate the caution on B12. Started increasing last week after seeing it isn't really possible to take too much of it
Opinion: Yes, protein absorption may drop a bit with age, but exercising is best way to prevent muscle loss aside from many other benefits as we age. Get a scale which measures lean muscle mass and body fat and start tracking. If you start loosing lean mass on a good diet and exercise then consider a little more protein in the form of higher protein real food, Things like nuts and beans. Avoid the powders.
Congratulations, Rimon. I haven't been here for a while and on watching this, I observed with joy, the astronomical growth in your number of subscribers. I used to feel bad when your numbers were still low because I never quite understood why such an informative channel would be under subscribed. The only way is up for you now. I hope your wife continues to make a good recovery. Best wishes.
Thanks a lot!
Collagen doesn’t have a complete amino acid profile. It doesn’t count towards your protein for the day.
I’m surprised that you didn’t add GlyNac to your 65+ supplement routine. It’s better than exogenous antioxidants.
It causes ED in middle-aged males
Agreed research shows it greatly increases Glutathione a master protective antioxidant especially in the Liver
Hi It's impossbile to cover all 65+ here. I take NAC, therse are only the changes and updates... In patreon I published complete reports and brands
Hey. Thanks again for the outstanding content. 😊 I've probably missed this somewhere but do you have any thoughts on a reputable glucosamine/chondroitin brand?
Prayers for your wife's ongoing recovery (and the continued success of your channel 😉) 😊
Re: Taurine. Recommend getting an amino acid profile which includes taurine. Then module diet, exercise and supplementation over time to get to high end of reference range. Makes no sense to just gobble many grams a day without testing. I'm 69 yo and have levels of a 30 to 40 yo according to data in studies and I only use 500 mg/d which I've taken for about 10 years for other reasons (vascular). Now taking 1 gram a day and will retest again soon. Same idea with Vitamin D (I take 5000 IU /d), Omega 3 index, test and modulate diet and supplementation and as needed. My D3 level is in 40 to 50 ng/ml range. Omega 3 index 7.8%, almost ideal ( i take about 600 mg of EPA and DHA, eat flaxseed and nuts and a little fish). Test when testing is available.
You take Taurine daily the past ten years? Do you ever take a break for a month before proceeding to prevent toxicity?
Most rcommend k2 with the d3.
How do you test the taurine levels ? In blood ? What’s the name of the test ?
@@PedroGonzalez-me1qb Taurine is an amino acid so you can get level as part of an amino acid blood test. Life Extension has a comprehensive profile for around $130. But you can google for other options.
Good video! Thanks for dividing supplement analysis into age groups (65). This is important for some supplements. I'm surprised you didn't do that for NMN, though. NMN is mostly used by older people to restore NAD levels to closer to youthful levels. I don't know if niacin can do as good of a job in older people. It is a good example of a supplement that doesn't make sense to use when younger, especially since it's expensive, but can be justified in older people.
Thank you I think I did say it's very good for 60+
C'est peut être utile pour des gens qui ont traversés de grosses périodes difficile où ils se sont abîmés avant l'heure non ? Une cure pour essayer de se régénérer Les niveaux de NAD dans ces cas là pour se réparer un peu, une bonne idée ou pas ??
@@michaelcaeyman9927from Southern Colorado Rockies USA I'd say great Idea who determines adequate damage ,no one but ourselves,the Dr. Here seems as though he's experimented on him self and parents and found a great base for us to build from Peace
You should look over Tulsi - holy basil. It’s so wonderful against stress and more.
I appreciate your efforts and valuable informations,thanks a lot
We appreciate your sharing your thoughts on these supplements!! Thank you 👍🙄
10:50
iirc l-ornithine does reduce cortisol as well
Very good advices, very good and wise, thank you
Oddly enough, English doesn't use an s after advice to make it plural. It's always 'advice' in both singular and plural cases. 🤔
@@User0resU-1 thank you! I will keep it in mid next time!
Good stuff...appreciate the info on taking care of our older parents. My mother so far has been fairly receptive to my suggestions. She's on medications so I don't want to overload her with supplements so suggestions such as bone brother are helpful. Being 65 myself..this stuff is important to me as well. Your work is appreciated.
Nice meeting you here. I have passion for 65+, it doesn't work well with youtube. I speak some about it in my updated supplement routine, what I do with my parents: wellnessmessiah.com/app
Couple of things, Taurine taken on the empty stomach in the morning will stimulate your gllbladder and improve bile flow. This will help to prevent stones from forming also a good easy way to jump start your day. Second, vitamin E should be in tocotrienol form - this is important. I also add CaAKG and some other amino acids before workout, and creatine. Creatine not just gor musvle growth but for stress and mental health actually which was surprising to me…different doses for men and women because of the way it’s processed, gender specific things…also a quick note on micro-dosing melatonin after 40. A few more things I had really good success with if it’s interesting, I can write later! 😊👍
Thank you AT! intelligent as usual
Women should take lower or higher doses of creatin compared to men?
@@danielstraka17 Women have lower creatine stores than men so yes, they should take less. 3g is probably enough
Interesting. Can you let me know the study/ paper that suggests taurine benefit for gall bladder benefit? Just name would be enough, since YT poofs most comments with links
@@akhileshp6419 just google taurine and gallbladder function
I take magnesium citrate in the morning and take magnesium taurate just before bed. Taurate is the salt of taurine, so the magnesium/taurine combo is great for many reasons, including healthy sleep. I also munch on some pumpkin seeds sometimes before bed because those are a good source of magnesium.
Sounds good protocol! well done
I too divide my magnesium need in different types of magnesium. I take magnesium taurate in the morning to also aid my morning intake of vit D (3000IU) and magtein (magnesium threonate) in the evening with my 2000IU vit D. During the day I take magnesium in my electrolyte tab due to me being chef I sweat a lot and need to replenish in plenty. I think this magnesium is glycinate, only the other two I buy specific. I like to spread doses even if it says I only need to take once a day, if possible I take half or try twice or three times a day. Shouldnt need to overdose unless known deficiency like I have for vit D, magnesium and probably B12.
@@AnnaMaria-zm8cv I take capsules daily of either wild caught cod liver oil or salmon oil for vitamin D, besides the sunshine. I get my omega 3s that way, too. Pumpkin seeds are also very high in magnesium. A handful before bed can help with sleep.
Thank you for providing all this good information Simon. I’m interested in exploring taurine for its heart and vascular positive effects. More specifically for mom who is 90 and other than for AFIB and arthritis she is pretty healthy, the biggest issue I find is that whenever I bring the supplements topic up to her doctors they say not to take them. She has AFIB, takes blood thinners and, deuretics, and BP medications, how could she safely start introducing taurine with testing to verify that we are getting all the full Benefits wo getting into trouble?
It's hard to tell Pedro because of potential drug interaction
Anyone have any recs for a good DHEA cream? I’m on the capsules but need to switch. Or do folks get an rx & have it compounded? Thanks!
I’d love to know too
Thank you you and Dr Gregor. Have him on your show
Lifted weights till now, ( 50 years ,l 1 gram nmn has helped rotator cuff pain shoulder pain and the lack of pain has helped reverse gradually loss of strength
im 84 .Loved this.
Lot of love, stay healthy!
Awesome content... awesome knowledge! I take over 50 Supplements. NMN is by far my favorite. It really makes a difference with me. THX
Nice meeting you alexander, NMN is powerful, yet the lack of data still make it difficult to know exactly how and when
Interested to find out if you’ve heard Chris Masterjohn’s warning of NMN supplementation leading to excessive filling of the niacin pool and epethial damage to vascularature. I need to try and read his post again because he’s incredibly technical. But he cautions against high dose NMN.
I read about the B 12 problem. I have a question though. Did they they make a distinction between those who supplemented methylcobalamine and those who supplemented with cyanocobalamine? It's my bet there is a difference.
No. It's a good distinction like you said... BUT I remember they measured blood B12. I need to check this
I took 10,000 IU’s of quality Vit D throughout the pandemic. Never got sick BUT the skin on my hands and feet literally started peeling off because of Vit D toxicity.
Taking powder form as opposed to natural sunlight will obviously be
Absorbed differently.
Like he said starting at 4000 IU’s should be fine.
mb u used tons of antibacterial sops ,etc???
Was hoping resveratrol , apigenin, astraxanthin and tumerec would also be covered
Only the changes and updates... In patreon I published complete reports and brands
Yooo you gotta do intracellular NAD+ (powered form) water soluble and raised me levels from 27 to 50 in a week
HI, What lab do you use to get NAD levels checked? thx!
I live in Hawaii and we all live in our bathing suits getting lots of sunlight on our skin. It’s almost impossible to get vitamin d levels higher than 50 naturally from the sun. Only supplements can cause it to go higher.
Sperti vitamin d lamp
It's interesting. It could be that supplemental vitamin D circumnavigate some skin regulation . On the other side, in the video I spoke about 70,000 years ago - people going with no clothes all day long. Large areas are back, chest.. these are still hidden vs the past.
HI Rimon: i take niacin, first few days I got the flush but soon developed tolerance to it no longer have any flush with it, I suggest start with a low dose for a week and gradually increase , I take anywhere from 500 to 1500 mg Niacin flush per day, both for Mitochondria health and lipid profile.
Keep an eye on your liver enzymes. Niacin at 1000- 1500 mg can damage the liver.
Take Niacin with Vitamin c amla
Milk thistle
Glycin
Dextrose
There is no flush
I need metholated B Vitamins. Other wise on deficiency. I have a metholated issue. The same with NAC I'm low on glutathione. So I have to take liposomal Glutathione
Great info. If worried about TMAO, take about 500mg of a garlic extract with your food. It will lower TMAO.
Didn't know that. Thank you!
I have been taking Taurine for several years and do notice when I go a few days off of it. Like you I am not sold on the NMN. Ashwaganda is a no-no for me it makes me feel very weird. The supplements my body clearly “misses” when not taking them are: Taurine, Magnesium and Creatine.
Huge Thank-you ! All Great Info. ! One Full Body/Brain , Natural Supplement that You Did Not Mention, I take Daily as well as My Mother in her Late 80's Is Creatine Monohydrate ! Your body produces Naturally but as We Age it is Imperative for Good Health and Longevity ! Cheers !
Yep, I'm 75 and take 5 grams a day along with my whey protein powder. I also take 3 grams hmb to ward off muscle wasting. He also didn't mention NAC and glycine.
Hi Johnny there are only the changes and updates... In patreon I published complete reports and brands
@@WellnessMessiah Title of Video ...Longvevity Supplements ! ! Creatine Monohydrate Should Be In The Top TWO ! And Was Omited ? ? ?
Nmn is absorbed better with tmg also take it with glycine and I take quercintin with it to activate mtor
Great info as always!!🙏 What brand of fisetin do you recommend.
Thanks for this. You’ve convinced me to start taking Taurine for the first time. I didn’t fully understand when you take it and why and how to stop it interfering with sleep
The comment about exercise and joints is valid. However not all exercise is equal on our joints. I swim & often use training aids like paddles and flippers. Increasing the load on my muscles but not joints. Win win
Yes of course. The video is too long to get into subtle influence of exercise on joints...
There's a lot of hype towards NMN and NR. Probably it's due to commercial interests. Niacin has been on the market for a long time and isn't a good business for labs
I eat yeast spread once-twice a week therefore I don't have to bother with niacin or b-Complex supplements, nonetheless overpriced NMN...
@@danielstraka17 how does yeast raise your NAD levels. What does it have?
Carnatine - 1 to 1.5g, not 1g to 1.5mg. Just a mistake, of course. But worth pointing out, so nobody gets confused.
Yes correct thank you
I can not easily mix Taurine with water. It floats on the top, makes a cork, very light, doesn't want to dissolve or mix in any way. I take capsules therefore.
Since your video I have tried to find NOW super antioxidants and think they do not make them anymore. Do you have an alternative suggestion? Thank you
For CVD prevention, I’m taking 100mg of Niacin along with bergamot. I used to wash my supplements down with a protein smoothie that included banana, but I replaced the banana with apple because there’s a compound in banana that blocks the benefits of polyphenols found in berries and bergamot.
Wonderful presentation and presenter , comments out of this world, kicks ss, Peace
Hey Ramon Love your channel.❤ What is best to mix the taurine powder with? The taste is pretty bad. I cannot swallow capsules either. Thank you
It should be tasteless... I would try magensium glycinate or glycine powder - it has a natural sweet taste
Great information, thank you! I was researching into the NOW brand super antioxidants, and it seems that the bottle used to be $17, then the price was increased to almost $40, which does not really matter because it is not currently available; so I am thinking I may try to get quercetin on its own, and less you have a different suggestion.
Hi yeah $40 is too much. if you find 50mg quercetin that will do it... it's super strong be careful with extra doses. I explain more on quercetin doses and uses in this report:
www.wellnessmessiah.com/gift
Listen to this guy to slow your aging to a halt.
Like your channel very much ❤
Thank you for your incredible work!
Are you at all concerned about the recent study showing cardiovascular inflammation from excess niacin intake? The metabolite of concern will likely be impacted by NMN as well. What are your thoughts? Thanks!
No, I looked into the study, I wouldn't worry about it. Here's why:
1. The study was metabolic association with outcome.
That is, an association with sick people. A double weakness. Not a cause, but an association. Not healthy people, but people with a history of heart disease. But a heart attack or a cerebral event more than 3 years ago. Therefore, "stable patients".
2. They found that there is a genetic defect in part of the population that does not resolve from a byproduct of niacin. In fact, it is very possible that this genetic defect is the reason they initially developed vascular disease.
"suggested that niacin metabolism was associated. Phenome-wide association analysis of the genetic variant rs10496731, which was significantly associated with both 2PY and 4PY levels,”
3. And here's the highlight. The researchers linked this to niacin. In my opinion, this is a serious mistake. The byproduct 4PY comes as a result of niacinamide. Not from niacin at all. That is, niacin needs to be converted to NAD which will turn into niacinamide.
It's important to emphasize, NMN and NR produce much more niacinamide and therefore 4PY than niacin. This is actually a case for niacin and less for NR and NMN for people with this genetic defect.
4. The main conclusion currently is that there may be a certain group in the population paying a "price" for NAD boosting. They will get more NAD, but some will not be able to properly get rid of its byproducts.
5. And the second conclusion is that this strengthens the case for taking TMG. That is, it's very possible that TMG protects from heart diseases not only because it lowers homocysteine, but reduces other toxic metabolites we're not aware of from niacinamide (which is known to be toxic in high amounts... I mentioned that in my videos)
6. I wouldn't worry about niacin in general, but I would thoroughly examine the certain byproducts of NAD+ boosting. Maybe there are things we can do to reduce them? Maybe there are people with a genetic tendency who don't derive the value from them that the rest of the population does?
These are important questions.
But we need association studies and the use of precise terminology and not to lay the blame on "niacin".
It could be that these metabolites also indicate kidney insufficiency.
methyl-niacinamide would normally be excreted via the kidney. Not becoming 2PY and 4PY.
That's what happens with metabolic studies, you never know what caused what... I wouldn't rule out difunctional detoxification underlying secondary cardiac event here
Wow, this is incredible research. I know many in our community are asking the question that I did. However, I don't think anyone has answered it as well as you did. I know it's tough to find the time, but you may want to do a short video on this as it's gold. Such important information and so well-researched. Thanks for all that you do!! And God Bless you and your wife. Wishing her a good recovery.@@WellnessMessiah
Thank you very much for you proposals, which I apricate a lot
I am not sure where the idea that B vitamins are in highest concentrations in vegetables. I always thought that highest concentration and dosages of b vitamins you get from liver and other organs and meat.
Thanks for the thorough review.
Thank you for sharing your insights, informative and much appreciated. I may be wrong, but you may want to double check the units Vit D (40-70 nmol/L ?). I think you meant ng/mL (?)
Yes you're correct it's a mistake
Hi Rimon, Happy to see you again. Very informative another podcast.
Most appreciated.
But lately after eating my first b/ fast my blood pressure is dropping. Normally I was on OMAD.
But I’m afraid so much from low pressure so divided my meal into two, one is B/ fast am & dinner is latest 3 pm.
If I eat protein I'm ok if not it drops to 80 / 59 or 85/59 Because of carbs,
rare but
& 102/ 56 or 90/59 mostly. something to do with my cortisol levels, they are low
But is there a relationship with the molecules, I don't know🤷♀️
Once I went to a private clinic but couldn't find time to talk with the doctor, I had a flight to catch so wanted doc to give me the results on the phone but she refused it😢This was years ago.
Also Next week they will monitor my BP 😛.
Lack of protein caused some of these problems but now started to eat Turkey meat etc♥️ also began to take 500 of metamorfine. ( bought from abroad) Listen to our valuable Scientist Prof David Sinclair🙏
Thank you, Rimon most trustful and helpful videos.,
I keep on praying for your lovely wife🙏🌹♥️
God Bless you & your wife🙏🙏
I've been taking all of these and many more, over 100 different supplements every day.
How much do you spend on supplements per day, week, month?
Over 100??
@@babyreps365 I don't know. Over 100 dollars, maybe over 200 dollars.To be 75 years old and feel like 30 is worth it. Here's a tip. If you want to increase muscle strength and size (without exercise as I am a lazy bum) take BCAA and HMB. Branch Chain amino acids are anabolic for muscle while HMB, a metabolite normally produced from BCAA but in insufficient quantity is an anti-catabolite for muscle. For a specific muscle contract it at least 75 percent maximum and keep it that way for at least 30 seconds (I got that out of a physiology textbook many years ago.) And of course you must eat protein. Other supplements help too.
@@evarkf I really should update my list. I don't think my doctor ever heard of most of them. I asked her about Honokiol and she never heard of it. It comes from Magnolia bark. I'll soon be ordering Urolithin A and PQQ. You couldn't possible get enough of the things I take in your diet every day. BTW the best source of PQQ is dark chocolate, 90 percent cocoa. I learn something new every day. I have many interests and extending my lifespan and healthspan is just one of them. To be honest some of them do scare me and some of them have resulted in blood tests out of the normal range and had to be terminated.
Only 100? You're left behind mark!
Thank you so much for the Great content, I trust you more than any one ,could you please share which brand of vitamin b3 ( niacin) and collagen do you use ?! Are you recommending whey protein for people over 55 or 60 it has all the amino acids especially for those who don't eat red meat alot maybe once a week?! Greatly appreciated 🙏❤😊
Hi Monir, trust yourself more than me. This is what I do. The brands, I share with my mid-level patreons www.patreon.com/WellnessMessiah
Are you measuring your epigenetic biomarkers?
What do you put that 5g of taurine into, Rimon? I've been taking capsules but will probably switch to the powder. 💠
Hi into my collagen powder, with magnesium glycinate which adds taste- naturaly sweet :)
@@WellnessMessiah please clarify-- have read that you should not take taurine and glycine at the same time because they compete with each other for absorption
Hey Rimon - could you take a look at Moldavian Dragonhead extract? Allegedly it’s a ‘natural NMN’…
Hi ask in our group:
www.skool.com/longevity-hackers
Rimon, what do you think of Ray Peat's approach that advises to keep metabolic rate high including to prolong life?.
Makes little sense on the surface... animals with low rate live much longer, centenarians have low body temp (affects metabolic rate), etc. Never looked into Ray work
@@WellnessMessiah Maybe you could chat about it with some of his proponents such as Georgi Dinkov, Mike Fave.
@@WellnessMessiah ua-cam.com/video/3cI9xCbtq1U/v-deo.htmlsi=w0X17ITlqlTnH3Ed
What are your thoughts on MCT. Oil?
what form/sources of collagen do you suggest?
I have never heard any expert suggest that NMN prevents cancer. I have experienced numerous benefits from NMN which I have been taking for five years and feel 10-20 years younger than my 70+ years.
My comment, of course, relates to the ITP results which show no life extension in mice taking NR.
Hi as I said - what matters is the end result. If NMN makes you happy, gives you what you want - nothing could be that.. not even the best studies. Results always win. Lots of love
Error in your vitamin D blood test target: I think you mean 40-70 ng/mL, not nmol/L, because 40-70 nmol/L is only 16-28 ng/mL.
yes, you're right!
Maybe it's the afternoon when you want to exercise, and not take a nap. I have taken taurine straight. But I had to take it separate from meals. Currently I take Magnesium Taurate with meals, twice a day.
Are you aware that tocotrienol is 50 times more protective of fat oxidation than tocopherol? I learned this from an hour long interview on Modern HealthSpan about six months ago. I apologize for not knowing the doctor's name, but he spend most of his life studying tocotrienol. He also said that tocopherol diminishes the effect of tocotrienol, so they should not be taken together.
For those who have had radiation treatment, I use tocotrienol together with pentoxyfilline to reduce fibrosis from radiation (see the papers of Dr. Sylvie Delanian for dosages.) This combination, although I used tocopherol until recently, has kept my throat open for decades. It is common for fibrosis to keep growing and fill the throat so that a feeding tube is required. Many ENT doctors know about this cocktail now, but not about tocotrienol.
Also, for fat soluble vitamins like D, K, E, and A, it's best absorbed in the presence of fat from food. Maybe eat a bit first, then take them. For myself, it made the difference in absorption .
That was great and thank you very much ❤
Nice meeting you here
Question. Although as older individuals we absorb less of the protein we eat- it will still all count as calories? So we have to eat more calories to get the same amount of protein as when we were young?
Hi Margaret ask in our group:
www.skool.com/longevity-hackers
Is Taurine the same as L-Taurine? Some Internet sites say there’s a distinct difference. I read something about Taurine having a different chiral configuration from L-Taurine, which makes all the difference in the world as to if and how the body uses it properly. I have not seen L-Taurine at stores lately. I have Taurine at home now wonder if I’m wasting my time taking it?
Hi ask in our group:
www.skool.com/longevity-hackers
Can you do video for young people, like what supplements they should start taking?
Hi technically, I have already created such a video. These 3 supplements super important for young people:
ua-cam.com/video/Xz9yJq5SPvA/v-deo.htmlsi=TMJTSWC2Fh6c_ohy
@@WellnessMessiah Thank you!
Is there a fish oil u recommend?❤
Use algae based DEA omega 3. Fish oil has too much chance of being rancid which has opposite effect
From reputable brands with 3rd party certification either USP or IFOS5
Thank you so much Rimon for this video. I am a 70 yrs. old African American female in GOOD general health but do not feel the energy I used to since turning 70. I am on bio-Identical hormone replacement cream (16 yrs. now)--not due to any disease. It was elective for me as a way to manage aging. Is it OK for me to add DHEA cream? Also do I understand correctly that I can try either Niacin OR NMN? I don't need both? Thank you.
DHEA can and mostlikely will cause hair lost. Becareful dont go over 50mg and watch your hair closely.
You said we need to take a gram of MNM a day. But how about taking Niacin (I take 500 mg of sustained release) + 500 mg of NMN?
Hi I think it's fine. But timing matters a lot. I would take e.g. 500 mg NMN in the morning and after 8 hour 50mg niacin and again after 7-8 hours. Feeding NAD enzymes all day long. It's probably would be my future routine :)
Beautiful research thanks for Sharing
Hi Rimon, do you still drink coffee or matcha? what do you think is best if I ever to choose only one?
yes, I drink both coffee and green tea - all kinds. The best is - no sugar, no milk, both green tea and coffee (away from sleep) are good - not personal recommendation ) e.g people who have high BP should be careful, etc - just what I do.
Good info, hard to understand sometimes though. So you only take 50mg of niacine per day or 50mg a few times per day?
separated, so I take 100-150 mg per day. Usually every 8 hours - the time to consume the average NAD molecule.
NMN has incredibly improved my eczema on my hands which I have year round. I started NMN last week. Also, I was having crazy inflammation in my body which led to incredible hair loss and NMN has helped my hair to stop falling out. I take it with TMG. So far it’s a miracle supplement. PS I’m 31 years old.
What is your dose of nmn?
surprised on the Vitamin D info. I've been taking 5k iu of K2 & D3 (cholocalciferal) and I get my Vitamin D measured since I've got osteoporosis. My last measure showed an increase in my bone density! I take a lot of supplements, but I thought it would have been due to the Vitamin D or NMN(?).
Hi it sounds like you body convert vitamin D well :)
Great content!
600 mg Ashwagandha @ 8 pm to 9 pm only seems to work best! Try to coordinate with time of day when cortisol is lowest minus Tmax for oral Ashwagandha.
I also avoid all prescriptions if I can. I even turned down statins and I'm using nattokinase instead. Some study actually found it far more effective at removal of plaque. I don't care for nmn too pricey and I didn't notice any benefits personally.
What is your nattokinase dosage per day?
So you were able to completely replace the statins by nattokainase ? How can you test in the blood that it is as effective?
I found Turine worked best on an irregular schedule and in combination with 5-HTP and Melatonin
Thanks for this video. What is the meaning of runaway ageing? Thanks
I would assume it means an exponential increase in the markers of aging.
What gerontodon said - exponential increase
Don't forget about your creatine monohydrate.