I'm confused about. Where did RNAp come from. Since it is an enzyme that means it's been through all the stages of forming the protein but we can't form a protein unless we have RNAp
Khaled Abdelghany the 2+ positive charges on the mg can stabilize the negative charges on two of the oxygens of the pyrophosphate, allowing it to be pulled out and the nucleoside monophosphate be attached to the elongating sequence
This guy is legend
thank you teacher
great video, thanks man
Wow this guy is awesome!!!!
RNA polymerase actually has the ability of proofreading. Great video anyway!
that might depend. RNA Polymerase II doesn't have this ability.
RNA polymerase does NOT proofread DURING transcription. That's why there's post-transcriptional modifications
Beautiful ! Ty
Thank u sir for teaching us
Hi there- In which lecture do you discuss the three types of RNA polymerase?
he's high on science , I swear
His accent makes me happy. "IT NEEDS DA BUILDING BLOCKS"
Ur genius sir
Thank
DNA poly has an exonuclease activity not an endonuclease domain !
I'm confused about. Where did RNAp come from. Since it is an enzyme that means it's been through all the stages of forming the protein but we can't form a protein unless we have RNAp
Too complex for me right now. Will have to re-visit after I advance a little more in molecular biology. LOL.
Thumbs upp👏🏻👏🏻
subcribed ;)
dude you're honestly my role model. can i just be you? lol.
xD
Cool video, but it wil be better if you talked about RNA pol subunits IMHO
definitely agree
DNA polymerase has exonuclease activity though not endonuclease.
Why is the reason that they need Mg 2+? Was there something related to evolution related to that?
Khaled Abdelghany the 2+ positive charges on the mg can stabilize the negative charges on two of the oxygens of the pyrophosphate, allowing it to be pulled out and the nucleoside monophosphate be attached to the elongating sequence
@@rajdoshi5956 thank you
I also think the Mg2+ makes the OH group of the 3' carbon a good nucleophile to attack the phosphate
I want to ask something that you didn't mention.Rna polymerase slower than Dna polymerase and why????
At 9:16 - it's 'exonuclease' activity, not 'endonuclease'
It will be endonuclease. It's correct
@@purnimasaxena7617 DNA Polymerase I possesses a 3´→5´ exonuclease activity or "proofreading" function
A warm little pond accomplished this how?
Ribonucleoside triphosphate or ribonucleotide?
+Pixy Wing whatever nucleoside, nucleoside mono, di or triphosphate is a nucleotide. there is no nucleotide triphosphate, but nucleoside triphosphate
+Medicina Terni a nucleoside monophosphate is a nucleotide
Both are same.
deja vu ?......XD
Great video except RNA polymerases can backtrack and proofread incorrect mRNA
No it can't. Only DNA Pol can proofread.
no it can't
No, it cannot. It does not have 3' to 5' exonuclease activity.
I don't understand your language