RAPAMYCIN: How Easter Island Led To The Discovery of the mTOR Pathway [2021]
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- Опубліковано 28 чер 2024
- Reading medical studies and boning up on longevity makes for some dry reading. Not so with the discovery story of rapamycin and the mTOR pathway.
Today's video is a 2-parter. The first part is the history of rapamycin and it's a tale with exotic locales and not one resurrection, but two; one from the last place you'd think. The second part of this video takes a good look at several studies of rapamycin, both past and present. And we'll examine rapamycin's role in the age-related decline in immunity and loss of muscle mass.
I'll admit it. I've never been a big fan of taking rapamycin to inhibit the mTOR pathway and possibly extend lifespans. But these studies have reset my thinking, and I may be changing my mind.
Chapters & Timestamps:
00:00 Intro
00:50 The Story of Rapamycin
05:30 Rapamycin Studies
10:21 Rapamycin & Immunosuppression
11:55 Rapamycin & Sarcopenia
14:52 Conclusions
Links to studies referred to in this video:
Rapamycin extends lifespans in mice: www.nature.com/articles/natur...
Opinion article on Rapamycin: www.ncbi.nlm.nih.gov/pmc/arti...
Rapamycin and the quest to slow aging through drug discovery: pubmed.ncbi.nlm.nih.gov/32467...
Rapalogs and COVID-19: pubmed.ncbi.nlm.nih.gov/33665...
Rapamycin, sarcopenia and aging muscle: pubmed.ncbi.nlm.nih.gov/31454...
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Sounds like you added a syllable to Rapamycin. Seems like you're saying.. Rap a my "ah" cin.
Like "al-lu-mini-um" :)
Rapamycin seems to be working for me - I've been on it for over two years now, minimal side effects (small skin rash, once a canker sore), but feel like I'm 15 years younger (in fact, my Levine phenotypic age is now 15 years lower right now - but i did not do the calculation pre rapamycin - so my generally healthy diet / active lifestyle may be the key factor). Stiffness and pains have largely gone away. Lost and kept off weight (for the first time in 20 years) - back to highschool weight and waist measurement, active as I was when I was 20 years younger.
Which reputable company can you purchase rapa from ? Thx
@@jimdres7000Pfizer - Rapamune
Rapamycin is available from compounding pharmacies at a huge cost savings vs CVS or other chain pharmacies.
There seem to be bioavailability issues with the compounding pharmacy product. Generic rapamycin / sirolimus seems to be best option.
Dr Peter Atelia In a recent podcast said that some of the compounding pharmacies do not include factors that make rapamycin more biologically available. Some people are buying from Indian Mart For less than two dollars per milligram shipped, This is not Recommendation
209 what is the name of bacteria?
Thanks for a great video on rapamycin. Much appreciated!
Glad it was helpful!
your videos are wonderful. please send more frequently.
Thank you for your videos, they are of great interest to me and others. Please do a little overview of sirt6 and its possible activators.
I'm working on a video on SIRT6 as we speak.
Great video. I’ll have to watch it twice for sure.
Thanks.
Like you I regarded rapamycin as an immunosuppressant, as such I didn’t want to suppress my aging immune system for an intangible benefit. Thanks for bringing these papers to my attention. Maybe I will change my mind as well.
Glad it helped.
Great information and presentation
Glad it was helpful!
Always great information. I'm curious if you looked at the studies done with topical Rapamycin for skin aging? The two I saw showed significant improvement in tone, texture, elasticity, reduced wrinkles and increased collagen of the areas applied. Really interesting.
I made an ointment myself. Aquaphor 99gr mixed with 40 mg sirolimus. I haven't seen much progress after a month until now.
Yes, I did see the studies on rapamycin for skin aging. But I didn't want to do a 20 or 30 minute video.
@@LanceHitchings perhaps as a piece of a video on skin rejuvenation -- maybe as a follow up on the one you did on skin care last year.
@@Harosie any more progress on the skin?
love your video and just subscribed. Excellent clarity and sharing and honesty. Im currently in Mexico and I plan to go shopping soon for some. Will research it thoroughly. If you require any please let me know as I found metformin at local pharmacy easy enough but I believe I have to go to a bigger hospital to find Rapamicin.
Las consigues en Farmacias Especializadas, sin receta
Good explanation, thank you!
Glad you enjoyed it!
Very interesting update on this key player in the longevity movement. I will travel to multiple Asian countries when they open from covid and will keep you updated on availability and costs.
Thanks, Jason. Always good to hear from you.
Rapamycin (sirolimus) is easily available, prescriptions are easily available. No need to travel to asian countries.
All day chemist mail order.
Great video!! Always looking fir more info on rapamycin! Wanting it for whole body inflammation due to arthritis, especially in hips n back.
Also what does anyone think of life extension products??
I’ve taken many supplementsn the brand seems a bit weak to me
I take Rapamycin in form of Sirolimus ever 6 days 5mg. I can hardly wait until the 6 days are over and I can take the next intermittent dose of 5mg. I didn't feel any side effects. I order my semi-annual ration in India so it costs me 1mg $ 1 including shipping. In addition to other medications, I also take 1.5 grams of metformin daily in the evening.
@harosie Could you share which provider you use?
Thanks in advance.
@@iblisthemage If there are any more questions it's ok and if the email link should not work please tell it and i try to look in my account.
@@Harosie Hi @Harosie, I am afraid I didn’t understand, did you post an email adress? I can’t see it… :-)
@@iblisthemage I replied you in a long text but that message is maybe deleted. Maybe that's against some Rules. I don't know how I can give you your information
@@Harosie That was very kind of you!
I have the email address iblisthemage@gmail.com, perhaps you would try that?
Thank you so much for your time :-)
Great video Lance, really valuable information and your concerns echo my own about the potential for mTOR inhibitors to prevent building muscle. I’ve stopped taking metformin daily for the same reason and am struggling to get the information to guide the best regimen to cycle mTOR activation (to build muscle) and inhibition (for longevity benefits). Keep bringing videos on these topics and hopefully they can get out to more people.
Thanks for the feedback, keep watching. I might have some additional info about rapalogs in the future, I'm participating in the PEARL trial.
Hello lance, im following you closley, any ideas what to do about rashes from nmn, and where to get rsosmycin?
Very good information. Thank you. I have question: How old is too old to fast for longevity?
I've heard that mice do not have as much benefit after the mouse equivalent of 65 years for people. But that's mice. I have noticed that as a middle aged woman I don't feel as well after about 3 days of fasting as I used to, but the main thing is it affects my sleeping. I have also read that the stress of fasting causes one to put out more cortisol, which would explain the insomnia. I have started taking hydrocortisone, about 10 mg (I have a prescription) and that completely takes care of it. I'm guessing it's an individual thing. The only problem I could really think of with age is a slight loss of muscle mass, like maybe a pound of muscle after a month of fasting. The loss of weight is almost all from fat and the autophagy of senescent cells. By the way, the body does replace lost tissue with brand new tissue quickly. These new replacement cells are tantamount to neonatal cells.
Absolutely loved this man! Can you put subtitles in English too😅 ? Pls.
Super duper interesting video
Thank you so much 🙂
Lance, you should consider writing a book, you are really impressive.
I'm actually putting together an online course. Should be up in 2-3 months.
Thank you from Russia!
You're welcome.
I think you are putting an extra letter in the word when you pronounce it. It sounds like you are saying Rapamyacin instead of Rapamycin.
He is saying it wrong and it bugs me!
Can anybody suggest a good source for nmn resevetrol tmg. I am from India.
doesnt metformin also inhibit the Mtor pathway? which do you yhink is more effective and can they be combined?
I don't know about metformin.
Dr. Eric Berg on his youtube videos says that Growth Harmons can grow muscles even your mtor is slowed down due to atophogy (via long fast.)
How about the side effects of it? Do they relate to the mTor inhibition?
Not to my knowledge.
@@LanceHitchings Thank you, Lance. I always think of trying it!
How do I get a RX for it?
From you doctor? I've also heard of people getting it overseas.
RestrIction of certain aminoacids in diet may prevent AKT-independent actvation of mTOR...
Is there a recipe where you could grow cultures yourself? And are the people of Easter Island getting any financial compensation for its usage from drug companies? Is anyone on the island producing any themselves? Are the islanders aware they could sue for provenance?
Was mtor unnamed before the discovery of rapa?
Currently taking 15mg every 17 days
Sure....but why did they change from Mammalian to Mechanistic?
Not sure, but I think it was first discovered in yeast. So, mammalian refers to the same complex in mammals.
if rapamycin has such a large half life then why take it more than oce a week? shouldn't it inhibit mtor as long as it is in your system?
Great question, there a study going on right now, called the PEARL trial, to determine that. They'll be studying a few different doses. I'll be doing a video on the PEARL trial in the future.
seems very difficult to get a prescription
Purchase from overseas.
Not really - just search on "doctors that prescribe rapamycin" and you'll find lists of them.
Interview with Dr. Kaufmann on Health span saying Rapamycin studies pointing to shrinking hippocampus and Sarcopenia. She wouldn't ever recommend it to her patients.
Interesting. I haven't heard about the hippocampus, but I heard that it's supposed to help prevent sarcopenia...and this is backed up in a couple of studies.
Aha 634 take when fasting
What are the best supplements for alzheimer?
I'm not really up-to-speed on Alzheimer's.
Seems to me lowering carbohydrates to 20 gms per day or lower.
Cost to much and not enough long term studies for me.
ditto
I asked one scientist, who works with rapamycin, whether he would recommend taking it for anti-aging. His reply follows: "Blocking mTORC1 by rapamycin could have both beneficial and harmful events. mTORC1 is a major cellular hub and influencing its activity in various tissues can lead to many adverse effects. In my personal opinion, I wouldn't recommend taking rapamycin."
Unfortunately, you didn't name the scientist and the harmful side effects.
The story of rapamycin was very unfortunate and its real benefits were misunderstood. If used properly, rapamycin is not much more dangerous than ordinary aspirin or metformin. Both are also anti aging drugs and harmful but the benefits predominate by far. Especially in a cocktail of Medicine including a PDE5-Inhibitor ( I take Tadalafil 5mg). I'm 71 years old and i can't wait until there is a ready alternative, it would be certainly to late. Side effects of rapamycin are known and reversible. And my favorite scientists are Dr. Green and Mikhail Blagosklonny. He said " "Not taking rapamycin may be as dangerous as smoking","The time is now unless it’s too late"
@@Harosie His name is Yossi Tam. You can google his name & rapamycin. He did not mention the harmful side effects, but I rely on his opinion. I am 77 years old and do not want to experiment with anything with potential harmful side effects. As far as I know, rapamycin is not part of the daily regimen of David Sinclair, which says something.
I just viewed a youtube video, ua-cam.com/video/JEt6Vxw35JY/v-deo.html, which indicates what supplements David Sinclair uses, and he states that he does not recommend taking rapamycin.
I respect the science of David Sinclair and I read his book. But science is not black and white. He takes NMN and even Lance Hitchings at least questions that ua-cam.com/video/HiKTaCQaP78/v-deo.html. His recommendation of resveratrol is not confirmed in known studies, and even considered harmful in some studies. ua-cam.com/video/cVXTVb-0KkQ/v-deo.html. Nevertheless, I continue to take both supplements (in addition to others such as niacin, apeginin, TMG) even if there are still few statements from studies on people, precisely because I'm 71 and can't wait years. By the way my daily expenses for my supplements are about $ 4 to 5, less than a packet of cigarettes and $ 150 a month. Including my two most expensive medicin Dasatinib und Rapamycin. Regards from a German migrated in the Philippines.
@@shy-guy5544 David Sinclair says he takes the things he sells. He uses botox but doesn't disclose it.
I switched my VPN to Vietnam, got onto Baidu, and found a Chinese chemical manufacturer who sells rapamycin for $70 per kilogram. That will last you forever.
Just weigh the risk of not taking it. Shorter life! The latter being a certainty.
Lance, you're probably following this scientist already, but if not, I highly recommend you this profile (it's on rapamycin): twitter.com/Blagosklonny
I'm out of Rapamycin but I can tell you where I get my coke and roids from, lol.
It’s rapa mison
Not rapa my a sin
I'd take it,. 6mg once a week. Doctor is like, some idiot wants to take some random drug for no reason.
Do you get your doctor to prescribe it off-label, or do you get it somewhere else?
@@LanceHitchings Too hard to acquire so I gave up on the idea.
@@tangan6228
Healthspan medical in California
Online no video chat at
130 bucks and it’s shipped to you monthly
@@dr.reviewsfrompersonalexpe7603 I am tracking on healthspan but they want $360 a month. Can you provide a url?