HALLMARKS OF AGING: Beat Stem Cell Exhaustion (YOU CAN!!!) & Live Long [2021]
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- Опубліковано 28 чер 2024
- STEM CELL EXHAUSTION: The Hallmarks of Aging. It's been over a year, and we're finally at the last hallmark! It may be last, but it's by no means last in importance. Learn why this hallmark may have the most actual impact on aging.
In this video, we explore why stem cells are so vitally important, what they are and why we start to run out of them. After examining the consequences of that, we'll tackle some strategies to restore our stem cell populations.
02:17 What Is Stem Cell Exhaustion?
06:08 How Does Stem Cell Exhaustion Occur?
11:40 How Does Stem Cell Exhaustion Impact Aging?
12:30 Can Stem Cell Exhaustion Be Alleviated?
LINKS TO STUDIES REFERENCED FOR THIS VIDEO:
Stem Cell Aging... www.ncbi.nlm.nih.gov/pmc/arti...
Cell Proliferation... www.ncbi.nlm.nih.gov/books/NB...
Effect of Aging on Stem Cells... www.ncbi.nlm.nih.gov/pmc/arti...
Quiescent Hematopoietic Stem Cells... www.ncbi.nlm.nih.gov/pmc/arti...
Autophagy & Stem Cells... www.ncbi.nlm.nih.gov/pmc/arti...
Quiescent Hematopoietic Stem Cells Accumulate DNA Damage... pubmed.ncbi.nlm.nih.gov/24813...
Telomeres & Stem Cells... www.ncbi.nlm.nih.gov/pmc/arti...
Stem Cell Aging/Lifespan & Disease... pubmed.ncbi.nlm.nih.gov/32053...
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I'm a Biochemist and really appreciate that you don't "dumbdown" the information like most channels do. Makes it more succinct and gets more information out,
What about reactivating our so called "junk DNA"? it is not junk is just simply deactivated. We used to have that DNA activated many years ago and we were able to use 100% of our brain and never aged.
I agree, because that's something that bothers me a lot from many other videos out there, even sometimes videos with a very good content anyway but addressing the audience in a very condescending, snobbish or very elitist kind of way, so to speak.
Thanks, glad that you appreciate it. I've thought long and hard about how much info to include.
Thank you Lance. So informative and thought provoking. can't wait to see your future videos.
You're welcome.
I especially love the transcript of the video as the language & spelling is so good that it can be read by itself with or without listening to the podcast. Very much better than some of those more famous podcast from the famous scientist etc.
So I was a stem cell donor for a leukemia patient at age 64. I was led to believe my stem cells would replicate quickly as though I was donating blood. I am constantly tired since then. Big change in the appearance of my skin. Stem cell donors are not usually actively recruited over the age of 40 as stem cell production slows with aging from that point. I feel I was mislead, lied to and screwed!
Wow, good to know, and sorry to hear that. Hopefully, a therapy to increase stem cells will come along in time.
you should do stemcell therapy if you can afford it
So glad you're back on UA-cam after your absence. 👍 Looking forward to more new content.
Thanks
can we appreciate how coherent he was presenting this topic. Great presentation chief!
please
Thanks.
Well done! This is one video that I think I can get my wife to take the time to watch. She's very committed to her health but usually leaves the science reviews to me to then pass along to her. Getting her to hear my sources is so much better, of course. 👍👍
Hope she enjoyed it as much as you did.
😀
So happy I found this!!
Great, glad to have you on board.
Great job. You just received another subscriber!
Thanks. Welcome aboard.
As always an excellent presentation. Looking forward to your video on GDF11. Do you have any thoughts on the effects of long term fasting of 20 to 30 days on stem cells or curtailing aging in general.
I found a lot of contradicting data on GDF11. Still want the video?
your diction is excellent - every word is clear
Appreciate it
Hi Lance,how do you feel about the compound, AC-11 and it's benefits?Thoughts?
Haven't heard of AC-11, I'll have to check it out.
thanks Lance. Could be NMN instead of Rapamacyn ??
Hi Lance, your videos are very interesting. Since I like to know where the information comes from when people show me scientific topics, could I ask you what your data source is? Do you get information from scientific literature (with impact factor), PubMed, or similar? Also, may I ask you what your background is? Are you a scientist (PhD or MD), a scientific writer, a scientific journalist?
Sorry for all these questions. I like to know about people that talk about science.
I list all of my sources in the description. No, I'm not a scientist or a doctor, although I do use a couple of medical researchers. I'm just a layperson who's passionate about longevity science and have found that I apparently have a knack for making complicated concepts more simple...for other laypeople. I think of myself as a synthesizer.
Great video. Thoughts on Berberine as a MTOR inhibitor as opposed to spermidine? Completely different, complementary or an alternative?
There are studies out there that state the berberine can inhibit mTOR. I'd say complementary, but that's just a guess.
Lance. Any thoughts on this DNA methylation diet that Modern Healthspan is covering via Dr Kara Fitzgerald interview series? BTW - your channel is dangerous to my job security in that I'm more interested in your content than work.
Haven't watched that video yet, but diet is just one of the things that can improve methylation patterns. Sorry about being to interesting, I'll try to make it more boring.
Thx Lance. Impressed by your knowledge!
Glad you enjoyed it!
What about tests to determine what effects these substances taken in are causing? The tests, done periodically should help us determine whether to continue or change our regimens. For starters, conventional blood tests, also homocysteine, CRP, methylation. There is an extra blood test to check for the effects of K2 as MK7.
I believe that interventions should be done with precision, and I just posted a video about different tests and monitoring devices that will provide personal data that will deliver that precision.
That was cool
Thanks
Yamanaka factors was discovered way before 2016?
helpful content
Thanks.
What about embryonic stem cells and combined with a super strong treatment of senolytics before initiation ?
Personally, I think that stem cell replacement is too new to try it as an intervention. It could easily cause cancer. As far as senolytics go, not sure about "super strong". There seems to be a notion that if a little bit is good, more is better. I'd avoid that kind of thinking.
@@LanceHitchings well your perspective has changed over the past year!
But if stresses exhaust them does that include hormetics as well ?
Great question. i think that stresses like toxins or stresses from worry is what I'm taking about. Stresses from working out tends to be beneficial, which falls under the broad definition of hormesis.
I would be interested to know your opinion on epitalon
To be honest, I'm a little skeptical. It's really expensive, I've only heard of one company that produces it, and it claims to reset the biological age of your cells to zero. Sound like snake oil to me, but I could be wrong. Needs more investigation.
Did you ever make that GDF11 video?
Have you developed your online course yet? I would love to do it if its available!
Working on it. It's slow going, because I'm doing so many other things...like stem cell therapy in Costa Rica.
@@LanceHitchings I would love to have you come to Cabo San Lucas. We have access to many new regenerative medical technologies here also.
I didn’t talk about how they would be improved that much
HI LANCE, WILL STEM CELS HELP WIITH IMPROVING GLUTATHIONE LEVELS IN THE BODY? ALSO WILL MEDICARE OR MEDICADE PAY FOR PATIENTS TO GET STEM CELLS?
I would doubt it!!
Don't know about glutathione, but I doubt the either will pay for stem cells. It's too new.
I didn't hear you mention *telomeres.* Did I miss it? Or are they irrelevant after all?
For telomeres, check out my video on Telomere Attrition. ua-cam.com/video/FyW560oNsmo/v-deo.html
There must be some other factor, we completly got no idea yet, getting old is like hardcoded effect. Of course we can take care of ourselves and living 110 healthy is worth making this effort, but this age seems like uncrossable barrier for bilions of people
The science is new and we're simply not there yet. But living to 110 might get us there.
Great info Lance, have you ever looked at Dr Valer Longo's book on longevity he has a FMD (fast mimicking diet) which when you do it has 3 month of stem cell regeneration everything you complete, I do it twice a year and feel a great, thanks for keeping us updated with the new data
Joint damage?
Yep, I follow Dr. Longo.
Go to 12:33 for answer
👍
Good video!
Glad you enjoyed it
I always look at the appearence of people who give these talks.
Lol I am 72...
Appearance is misleading, it’s how you feel and perform...
@Syd Barger people think that I am under 65.
@@christopherellis2663 that's wooow! What is your secret sir?
Love the world of stem cells
👍
EMBRYONIC AND BONE MARROW ARE THE TWO BEST STEM CELLS
Is autism be treated with stem cell therapy?
How old is Lance?
28
I turn 72 in 3 weeks.
I'm from BHUBANESWAR (INDIA)
I WANT TO KNOW ABOUT STEM CELL THERAPY CAN IMPROVE
KIDNEY CELLS .STAGE -V WITH MHD
Unfortunately, I have no idea. Good Luck.
🖤🖤🖤😎
Sugar and fruit and seed oils and refined carbohydrates along with lots of alcohol all have the power to --> rapidly age your body
We have a winner!
Spirulina
Pt 141 didn't work for me just made me darker very disappointed felt absolutely nothing
Reinfused into
First of all, to push forward anti aging biologically as well as other forms of technology, join the US Transhumanist Party. Accepting everyone from everywhere as long as you agree with the wonderful goals and it is free.
_"Party",_ as in a political party running for office?
Already a member.
Kudos! Great info!Reckon Humans hv 23 pairs of Chromosomes!
Thanks
converting testosterone powder into cream
23 pairs of chromosomes not 26
Sitt on floor in a jogga position, get upp again without using Yr arms.. Then you know your age
utter nonsense
Everyone's entitle to their own opinion. Personally, I'll listen to the science.