METFORMIN or BERBERINE? The Same? 1 HUGE Difference! [2021]
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- Опубліковано 28 чер 2024
- THE RED PILL OR THE BLUE? METFORMIN OR BERBERINE? Which should you take? There's 1 huge difference between them that could rock your decision.
Metformin & berberine, they've both been used for treating diabetes. And now they're both being considered by the longevity community. But there's one HUGE difference between them that could make all the difference in choosing between them.
In today's video, I'll be discussing both metformin and berberine, how much they're alike, how they both have the potential to extend lifespans, the drawbacks for each, and dosing. And I'll be going into depth about the massive difference between them.
Chapters & Timestamps:
00:00 Intro
01:20 What Are Metformin & Berberine?
03:09 How Do Metformin & Berberine Impact The Aging Process?
07:52 Drawbacks To Metformin & Berberine
12:16 Dosing With Metformin & Berberine
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Link to the previous video on metformin:
• ANTI-AGING EFFECTS OF ...
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Links to studies mentioned in this video:
Metformin & Exercise: www.ncbi.nlm.nih.gov/pmc/arti...
Effects of Berberine & Exercise on Humans: ijhs.shmu.ac.ir/index.php/ijhs...
Effects of Berberine & Exercise on Rats: www.researchgate.net/publicat...
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![WHY I STOPPED TAKING METFORMIN! And Switched To Berberine [2023]](http://i.ytimg.com/vi/q2ym7yUUQoM/mqdefault.jpg)
![WHY I STOPPED TAKING METFORMIN! And Switched To Berberine [2023]](/img/tr.png)
For all you you guys asking whether you can take both, when I was in Costa Rica with David Sinclair, he told me that he recommended both to several of his patients. I've also read several studies where they administered both and reported no ill effects, beyond those common to one or the other.
Sinclair is not a medical doctor so he shouldn't have patients
@@spartaleonidas540 you should never listen to an MD ! They make money from keeping people sick !!!
@@spartaleonidas540 Thank God he is Not an MD who Only give Big Pharm poisons. Good like to you Big Pharm Shill!
@@spartaleonidas540 -- He doesn't need to be a medical dr to have patients, obviously. -- He could be a paid health advisor at worst, or a Naturopathic Dr at best aside from an MD.
Anything D.Sinclair says... you can be sure it is useless and/or quackery. Guy has been all over the internet on his NMN and previously resveratrol. His scientific achievements are astonishingly weak and vague.
I was 65 and was put on Metformin. I did research and found out it inhibited brain clarity plus allot of other things - and I was studying for a 3 hr university exam, so I threw it out post haste. My research uncovered Berberine which did not induce brain fog + other benefits with exercise, which I was also doing. My blood sugar was 14.4 (I passed my exam btw) after 3 months I was down to 7.2 and then 6.2 a month later. My endocrinologist said whatever you are doing keep doing it. Berberine 500mg morning and 500mg evening. Works like a dream, for me at least.
Glad to hear that.
Ty..im not happy dr may ask me to take metformin..I exercise alot and daily I have 40 pounds to loose..I've gained weight which increased my aic..but I'm exercising alot n watching my diet...I can not tolerate the gi stuff since I have acid reflux n hiatel hernia..think it's berberine
Just started Berberine+Milk Thistle for better absorption. Trying Berberine because Cinnamon requires too much of a dose.
@@sandikillian4855 you’re doing something wrong if you’re 40 pounds overweight
What is the supplier of berberine?
Anecdotally I can say Berberine did far more for me than Metformin. Berberine does far more than just lower blood sugar. It has contractility effects on the heart, increases neurotransmitters dopamine, serotonin and norepinephrine. It reduces inflammatory cytokines, is an Id01 inhibitor. It's far more multidimensional than Metformin. Berberine also allowed me to exercise harder...and it felt like I was getting fitter.
Do you remember how long it was before you started noticing a difference?
@@YorkieUniverse1 within one week to two weeks... notable effects
I found that I feel more like exercising now that I have switched to Berberine, but of course, I can't "prove" it was the berberine, but I bet it was.
This drbeen guy showed studies Berberine also cleaned out the arteries, worked better than statins.
@@HarryJensen-kr4qzThat’s because statins don’t do anything FOR you, only sell statins the Pharmaceutical companies make.
I rejected my doctor's prescription for metformin 15 years ago, the doctor is not responsible for my health, I am! I don't take prescription drugs and I am almost 60 years old, my doctor also prescribed blood pressure lowering medications, I did one month only, never got it refilled. I take care of my own health, if I need a big pharma sales representative or a butcher, then I might visit a doctor, meanwhile I will continue to find alternatives, to avoid them altogether.
EXCELLENT CHOICES😊
My oncologist put me on metformin based on the properties it has to inhibit tumor growth
I was diagnosed with Type two Diabetes at age 56 and immediately went on Metformin, at age 63 I started having stomach and digestive issues because the dosage of Metformin was now too much. I switched to three 500 mg Berberine per day and three Tumeric capsules per day, Blood sugar has remained controlled with a A1c under 7, with no digestive or stomach issues. I also walk 20,000 steps a day.
I think you’ll find better absorption of BERBERINE taken in conjunction with Cinnamon
Great! BTW, did you lose weight? Have you seen the work of Roy Taylor?
You're content with poor results?
7 is diabetic. If you eliminate carbs and sugar your numbers will likely be normal.
@@Jack-hy1zq I’m 6’2” 175, I don’t eat sugars, rice, potatoes, pasta or bread, and my A1c is still 7
I'm a huge fitness and exercise freak. Recently I've been diagnosed with type 2 diabetes. I was put on 1000mg of Metformin and my workouts went to crap. Fast forward a few months, and I have suggested Berberine, I split my meds in two, morning Berberine and evening Metformin. My exercise is back to optimal.
Fit bu Type 2 D ? Get a realy good checkup ! There is somthing hidden underneath !
Wow that’s bad luck that a fit person would get that bad, were you a sugarholic?
Took Metformin and it put me into the bathroom, for hours. Switched to Berberine and it dropped my bs numbers by 50 points. Been taking it 3 years, I exercise regulary, no side effects. Tis an easy call for me. Good video. I am 75.
@Jay Dee Brand I use is produced by Amazing Formulas, dose is 1,000 mg, take it right after lunch and before I go to bed. Taken it over 3 years, continuously and it is still working. Also do keto, IF and one and a halh meals every day. so one pill each time or two pills per day.. Good luck.
There is a growing amount of Published studies on Berberine's Oncological / Anti - cancerous affects alongside it's well established use with treating Diabetes. Worth looking into. Oncologists in the US and China who have used protocols including Berberine have reduced the use of Chemo compounds by up to 16x when used in conjunction with Berberine. Dramatically reducing the risks of Chemo
What brand of berberine is the best?
I used metformin for 9 years and I had to live with what I thought was fibromyalgia. One year ago, money was short and didn't take metformin for 10 days. My pain was gone. Restarted it and it came back. Stopped it and it was gone again.
I stopped it once and for all. After researching I discovered berberine and I have been using it since May last year. I am up for my health check up and I will see its effect over my insulin (also reduced carb consumption).
Besides, no need for prescription.
Great example of listening to your own body. Glad that berberine is working out for you. Let me know how your labs turn out.
I am glad I read your statement, Willowy 13
I will be avoiding metformin as I do not need more issues.
Berberine works great without sides. Also used for hundreds of years. We can learn a lot from Chinese herbs. Especially on a diet. No cravings or feeling weak. Metformine has sides and is a med.
@@pamscarr8696 try Berberine. I'm very pleased with it. 😉
Willowy13 - Would you mind sharing how much berberine you took? I assume it was in tablet form? Whatever form, can you be specific? I want to give it a try. Do you have diabetes or prediabetes? (I have prediabetes just edging over the line into diabetes and I don't want to start metformin unless I have to.) Thanks and best wishes.
As you get older, by the time you figure out all this, you've likely already done a lot of damage to yourself. This vid is the best and most elaborate and effective out there.
The reason why there’s a lack of studies/research on Berberine is because it cannot be patented therefore pharmaceutical companies cannot make a dime from it. End of Story
I believe you :)
6 years ago I was put into ICU due to dehydration. I got so thirsty that I drank TOO MUCH water, depleting enzymes and electrolytes faster than I could assimilate them. BP went to 60/40. Lost 24 lb just from water loss. Doctor told me that metformin was a contribution factor to dehydration. I stopped metformin and reverted to "normal" water consumption. Took 3 days to regain BP and weight. My theory: If you eat a healthy diet devoid of inflammatory oils and excessive carbs you don't need any of these chemicals. I stopped taking ALL meds when I got out of the hospital and my health couldn't be better at age 75.
Been there!!
A very interesting discussion. I've recently started taking berberine for Type II diabetes. Anecdotally, it seems to have some benefits. I agree that a lot more research has to be done. But you provide a very good perspective. Keep it up. I'm a 70's senior and interested in factors that seem to have an impact on both diabetes and aging.
Removes plaque too. ^^ Healthier heart.
Big Pharma will NEVER pay to research an herb it cannot bottle up and call a drug, which it cannot sell for a huge amount of money.
For someone who is "not a doctor, a researcher, or scientist" he seems to know what he is talking about. Also refreshing is discussing the downsides as well as the upsides, and talking about dosages and absorbtion issues. Well done!
Read Pub Med (from NIH) is free to the public whereas the other line journals have a pay wall and you have to go to a university that subscribes to them to get access. Pub Med is on the Internet with no pay wall. I say anyone who is really interested can read the abstracts from the various papers and learn a lot from them.
I am a triathlete 67 who had some past issues with insulin resistance due to diet but on keto now for 3 years. I’m going to try berberine.
It’s important to note that the way you take berberine in traditional Chinese medicine is by grinding it into a powder and rubbing it on your tongue, chewing, and swallowing it. Western medicine has this fascination with taking pills but the bitter taste is important in how it is absorbed and utilized in the body.
Good to know, thanks.
you don't actually link taste and absorption though , do you ? rather "putting up with the bitter taste is requisite to ingest Berb transdermally, in the traditional fashion ? " . I don't mean to nitpick I'm just curious if anyone suggests taste is linked to efficacy.
It's not the "taste" that is helping, it's the simple fact that activating it in the mouth can begin absorption in the mouth slightly instead of only ingesting it. Some things absorb in the mouth, and the saliva may also begin the breakdown process different from just stomach acids.
There are some drugs you can take by rubbing them into your gums as well.
I've heard that nmn is best taken liposomal
The same thing applies to most Indian ayurvedic herbs. That they work better when you actually taste them, the bitterness etc. Versus taking in a capsule. However I have taken many in capsule form over the years (taste of many of these powders is just horrible) and they were still very effective.
My personal anecdote is as follows: I was bordering on metabolic syndrome so my naturopath put me on metformin. I took it for about a year, and it brought down my A1C from 7.2 to 5.6, but did nothing for my fasting blood glucose which averaged 105 across the entire year. The other negative was that I lost significant endurance during exercise ( hiking, mountain biking ) and would top out way earlier than ever before. It was like metformin made my entire body weaker, my muscles would stop working long before prior times on the same hikes/routes I had been doing for many years. So, to say metformin makes more glucose go into the muscles? I cannot imagine how that could be the case, it certainly made my performance worse and made me more tired overall.
I’ve been experimenting with a very small dose of metformin for anti-aging purposes. I didn’t realize it caused muscle weakness but I have been noticing that I’ve been feeling much weaker than usual at Pilates and I had to take more breaks. Glad I saw your comment or I may not have made the connection. Thank you.
I have heard of a couple of studies that associate Berberine with Liver toxicity with long term use ? Any information will be appreciated.. thanks
I read that metformin speeds up muscle loss!
Your naturopath put you on a statin?? 🤔
Metformin lowers your natural testosterone by 50%. So if you’re not on TRT it will make you weak as shit. And tired and depressed. So take testosterone with it and your fine.
I stopped several years metformin because it was giving me stomach issues. I been taking BERBERINE and I feel fantastic 😍😊
I've been on a keto diet since January and I have lost weight, but my fasting blood glucose was still too high, between 100 to 115mg/dl. 10 days ago I started taking berberine 500mg twice a day. My blood glucose readings improved noticeably after a couple of days. I've not changed my amount of physical activity, but now my typical fasting BG is 85 to 95 mg/dl. That's a big difference. Berberine seems to work. I'll increase my exercise routine and see how it does.
May I know what’s the brand name for berberine u are taking? Tq
May I know which brand of berberine u are taking? Tq
@@dannylai288 just take the nutrivein brand
Berberine works fantastic.
Maybe a mix of both would be wise
One side-effect about Metformin that scares me is that it blocks nutrients from entering the muscles, particularly Vitamin B12. To block nutrients from entering muscles will lead to muscle deterioration, and to think of it, our heart is 100 percent muscles; so here, we can connect the dots. My wife's aunt took Metformin for many years, and at the tail end of her life she was physically disabled. No doubt her muscles were being slowly/totally ruined over time.
I really enjoyed this. You put things in laymen’s terms and explained it well. Thank you. I’ll have to check out your other discussions. Thank you Lance!
Berberine, I took it years ago as a drink from a herbalist as she used the root of wild barberry. She used it to treat acne and seemingly worked very well., not for me for that. For years afterwards when we met she would say I was her second failure to treat acne over her years of using it. I didn't mind : It did improve my overall health and immune system incredibly at the time.
Excellent evidence-based video, very thorough and accurate on molecular detail (my lab studies diabetes). I would also like to see SGLT2 inhibitors studied in aging. Nobody should start on metformin without first having a basic metabolic panel to assess kidney function.
Great pace and presentation. Easy to digest. Thanks for making the video.
Thanks
I’ve been taking Berber ice for about 18 months just before bed. The strategy is to drop sugar levels for better sleep, kick start autophagy and finally reduce inflammation.
I don’t have any adverse side effects and it seems to help me sleep better.
Great video.
FWIW should you really drop glucose in your sleep, for some, it triggers fight or flight and you may get a adrenaline spike 2-3am keeping you awake. Thus the eating a small amount of complex carb before bed to prevent hypoglycemia in the night. FWIW I take 500Mg berberine too at bedtime, 1k in the morning. I'm just not able to add more dosings during the day per this fellows advice. ;(. Just mentioning for others that popping awake at 2am maybe hypoglycemia.. Best to all.
Good info Curt. Thank you. I used to wake up every night at 2 or three am and could not go beck to sleep without getting up and having a piece of toast. I got to 260#. Then I started IF and made it a lifestyle dropped 70# and have kept it off. I sleep through the night fine now with no food after 7 pm. Next day I won’t eat until 3 pm. Berberine is,part of my longevity strategy now.
How much do you take?
1200 mg. A supplement purchased on line.
@@KindergentlerMr.Softbelly sounds like a lot. When do you take if? I can’t have a problem sleeping! Help! 😂
I agree, more studies on both are needed
I take berberine to keep my candida in check. Works like a charm. 2- 3 grams a day with Oregon grape extract
I don't take either but have been doing my homework and what I'm finding is about what you are saying... The top anti aging researchers like Sinclair are just taking metformin on days they don't workout or do any exercise.. so they may only take it 1 to 3 times per week.. I say take berberine on workout days and metformin on days off... that's the study I want to see
Sinclair takes Berberine as well.
I think taking berberine after your workout or before bed would not impact gains but im sure that taking it before your workout would make your workout harder since inhibition of mtor pathway
@@god-zilla4233 ive been taking before workout and i swear im getting better pumps and stronger?
@@trentriver Not since he is on Metformin, based on an interview he gave. Did not mention why he switched to Metformin.
Metformin causes me severe gastric disturbances. I started researching berberine and decided to start taking it. I don't experience the gastric upset as with Metformin, so the question of M vs. B as it relates to exercise is a moot point for me, but glad to know that exercise will count. Thanks
Same here.
Bad gastric disturbance as well on metformin
I reduced carbs to under 150 a day and gastric disturbance stopped. Sugars set it off.
Its under appreciated that metformin blocks the B vitamine absorbsion, not just b-12. There's newer videos giving many many good benefits of B1/thiamine + variants on many low energy (etc) applications. Just mentioning for those taking metformin to test test test your B's and supliment.
Get the B1 and use Bragg nutritional yeast! Works beautifully!
Thanks!
I also take Benfotamine or B1 Thiamine (check Dr Berg)
Benfotamine should be taken by every diabetic
I supplement with nutritional yeast in bone broth to make sure I have enough B vitamins. I take 500 mg 2x a day of metformin and follow keto/low carb. I have zero problems with metformin. Labs, cholesterol and blood sugar are all stellar. I was pre diabetic when I asked my doctor for metformin and a glucose meter. I've also lost 60+ pounds in the last 2 years. IMHO, I think metformin causes digestive issues when carbs and sugar are still a big part of the diet. I had never really heard of berberine until recently tho. It's good to know we have options.
Very interesting content. I have taken Berberine for just under 2 years. I was diagnosed with T2D just over 4 years ago and put on Metformin. After a couple of months, I was on the the full 2000mg a day dosage. Well, I just couldn't get on with it. Terrible stomach cramps, flatulence and loose bowels in general.
I just stopped taking the Metformin, and, to be perfectly honest, I didn't notice any difference in my blood sugar control.
I'd already switched to a low carb way of eating,, along with intermittent fasting - aka late breakfast - and found that if I went for a short walk after my evening meal, I was just fine.
I discovered berberine later and thought I'd give it a go. I exercise regularly - resistance training and HIIT -and can't say I've noticed it having any detrimental effect on my fitness.
Studies are interesting, but the best study is N=1. My blood sugars are almost always normal, and have been since I changed my lifestyle and diet.
If you are keen on fighting the effects of aging, well, sarcopenia is definitely one aspect of aging that is best postponed as long as possible.
Thank you for sharing!
What is your dosage on Berberine?
@@GDixon-ch3ylHi, I take one 500mg capsule a day. I might up that to two, and take one at night, but so far, in combination with low carb, intermittent fasting, and regular exercise it keeps my A1c at non diabetic levels. Best of luck!
@@whomadethatsaltysoup thanks. Last July my A1C was 8.3 and I got so angry that it never improved. I knew it had to be food and somebody not telling me the truth, and it lead me to Ketogenic, Low carb and intermittent fasting and in one year I went to 5.9 and it's getting lower. I just want to get off metformin. Ugh.
You hit bullseye. Compared to overall lifestyle, taking herbs or medicine are no more than hacks.
@@faisal-ca Absolutely! The question: what is making us sick? Once we arrive at the correct answer, be it stress, sugar, alcohol or nuts, well, the answer is to eliminate the cause - not take pills, powders or potions to cover up the symptoms!
I don't need a prescription for berberine so I take that instead. Simple as that for me
Excellent
It’s expensive! I take both Metformin BB and
“StrictionD”. 3 months now.
Minimal effects…
There ya go.
@@badkarma6181 Berberine is great when on calorie restriction. No cravings or feeling weak. Metformine has sides and you need prescription. And Berberine has been used for hundreds of years.
@@Magic0165
I’d love to get off of ALL my scripts and go natural! But I’m in pretty bad health for being 65. I’m on powerful pain meds
Oxycodone, Meloxicam.
Pill for BP.
Pills for cholesterol and triglycerides (off scale).
Spine pain, hip pain.
Left arm and shoulder are worthless due to 2 neck surgeries. Nerve pain from neck and lower back. On and on and on.
I just wanted to retire and do a little traveling with my wifey and play some golf. Now I’m just lucky if I can get some sleep!
So much I can’t do as far as exercise goes. Which I need to help with the other health issues that plague me.
OK, enough poor me…
Thank you for caring and taking the time for that info. I will ask my PA about this next visit.
God bless you snd take good care of your spine, and family!
Happy Independence Day too!
Another banger!
Great stuff. Also I like the time queues between sections for finding information.
Glad you enjoyed!
Last night my glucose level was 266, after a meal. Took 3 capsules of Turmeric and 2 capsules of Berberine and drank a cup of black tea (of course, I didn't take them all in one shot). About 4 or 5 hrs. later my glucose level dropped to 130!! I stopped taking metformin a couple of years ago due to the nasty side effects of bloating, stomach discomfort and diarrhea. So yes, Berberine is the one for me, but I hope they do further studies on Berberine :)
Please, can you give me the specific brand of berberine you've taken?
Glucose should be measured just bf meal or 2 hrs after. 4-5 hrs after a meal 130-150 seem pretty standard. Cinnamon capsules have great affects of lowering Glucose levels.
@@ollady7968 I agree of course the glucose would go down after 4 or 5 hours ha have to laugh,.
Lol only 4-5 hours after ? That’s normal if you take nothing
hello there. if your sugar is that high 266 after a meal too high cut the carbs go KETO way of eating.. wow... I was only 130 so and it goes to 100 after three hours, yes, I checked at 1 n 2 n3n 4 hours that is normal drop, now I have been of medication for 7 yrs. sugar is normal, please do more get off all fake sugars and process foods. and any medication that covers the real problem food is and food can reverse it. good luck. look at dr robert lustig videos.
I am a long-time type two diabetic. I found Berberine about 5 or 6 years ago and started taking it (Swanson Berberine Complex with cinnamon, gymena, and fenugreek). I’ve been taking metformin for years and finally had to add insulin in 2016. It wasn’t til I added the Berberine that I started having better blood sugar control. (Most mornings my fasting glucose readings are between 70s and 120 compared to before Berberine-200s to 300s or more. I had to deal with stomach problems ever since taking metformin and didn’t know it was the problem. I take 2 1000 mg a day of metformin. I am going to wean myself from it and add regular exercise as well. I am told that I look younger than my age. Possible it’s a Berberine side effect. Also, my cholesterol has normalized due to taking psyllium husk (Amazon). Thank you for the video.
I completely reversed my type 2 with change in diet, getting into the gym and taking Berberine and Alpha Lipoic Acid. The ALA was primarily to reverse the nerve damage to my right foot (took 2 years but I got all of the feeling back) but ALA is also Insulin mimicking so it can help take some of the burden off of your Pancreas.
@@nosirrahx This gives me hope! Can you clarify what your change in diet entailed? What did you decrease? What did you cut out? Did you go with more protein? Less protein? Did you go Keto or Whole Food Plant Based? Please expound as I’m desperate to find out what to do.
@@bkfrance2 I got super into vegetables, I actually love them now. High protein is also the cornerstone to getting into shape. Lifting weights on a calorie deficit without going high protein will give you pretty terrible results.
I also got super into walking. I do cardio 7 days a week now and when I am really pushing it I go for 10 or more miles in a day. Usually its 1 to 3 though but it is 7 days a week.
Short term Keto is fantastic to reset insulin sensitivity and to break sugar cravings but I found that after a few months it becomes counterproductive. Currently I am low carb but absolutely do eat carbs pre and post gym, it really makes a difference for gym performance and recovery.
Intermittent fasting was also a great tool for me in the beginning because I was never more than 24 hours away from a very satisfying meal. Eventually though I needed to eat protein a lot more often to keep up with the gym but when I started it was a fantastic tool.
Add low carb, does work, that's your prob you eat carbs before and after training not good, protein after training does wonders,
Swanson has good stuff no doubt and their products seems to work. Though I tried Berberine and Fenugreek seed and has the same glucose after several months though. I wonder why it didn't lower. Otherwise their other products seems to work better for me. I just found the Berberine dosage and cost expensive with them and prefer Amazon (Unfortunately) But otherwise Swanson has many products you cant get elsewhere and is hence a must. They got stuff that you can only get from them in whole Europe.
As Jim Fixx once said, we are all an experiment of one. I think your discussion of Berberine is enough for me to launch a little experiment and see what I notice in my own body.
Good comprehensive presentation about metformin and berberine. I cannot take metformine as prescriptions that contain significant amounts of sulfur trigger an allergy. Berberine provides less of a inflammation risk. We desperately need more research into berberine as it is enormously promising.
Thanks.
Eggs have a lot of nutrition. I eat one scrambled egg with 1 tbsp of peanut butter 3 times a day alternating with a low carb vegetable dish and also 2 yogurt and cottage cheese and 1/2 fiber cookie.
I have tried berberine and it definitely lowers my blood sugar I don’t exercise a lot I do some but not much I don’t know about Met Forman but I can tell you that berberine definitely lowers sugar.
The company EuroMedica has a new product called Berberine Ultra Absorb that requires smaller dosages, better delivery etc. They also have plain Berberine, which seems obsolete now. Thanks for all you do.
thanks for the info
Thanks for the info!
So plain peregrine is not good
Excellent video! Thanks for the practical summary, definitely alleviated some of my concerns re. Berberine and exercise!
Dear Lance,
I really appreciate all your effort and scientific explanation about health in general, I'm a big fan! God bless you!
Thanks, I appreciate that.
Just found this video/channel. Such valuable information, and excellent organization and follow through of information. A+. 🙏🏻
Welcome aboard! Glad you found us.
my head hurts after focusing on your explanation here . Thank you!
I appreciate your well-balanced and engaging and informed video.
Thanks
Thank you for making this video. I've been pondering those very questions! I stopped taking metformin and berberine because of the possible negative effect of either on the benefits of exercise. I'm 75 but everyone comments that I look much younger. Exercise is largely why, plus good genes. Maybe nmn and other things have something to do with it, but I believe exercise is critical to slowing physical and mental deterioration. I thought maybe I shouldn't take metformin or berberine, then, and losing out on the positive things about them with respect to anti-aging. Your discussion answers my questions perfectly.
could you tell me where you get your nmn?
@@JoJo-oc8oq I was getting it from Renue By Science but just to see what I ordered 100 grams each from two Chinese sources. Took long time to get them, over a month, but lab tests found over 90% nmn for both. Much cheaper.
Within a week of increased dosage of metformin I experienced severe pain in my kidneys and now hover between 3a and 3b. Two years of Berberine and my A1C is at an ideal level.
Whoa! Thanks, this is incredible information for those of us interested in the anticancer effects of both exercise and metformin. Gonna talk to my doc!
Great video, I follow all of this, from my research, this dude is spot on.
Much appreciated
I can only speak of my own experience, but I have been taking metformin for over 25 years. I have found that, when I am exercising, regularly, my A1C numbers are always lower than when I have stopped going to the gym.
Best anti-aging channel by far, congratulation!
Check out David Sinclair Harvard professor
Thanks.
@@mobeykanobi5278 David Sinclair and Brad Stanfield. 👍👍
This is amazing content. Keep up the great work.
Thanks, so much.
Nicely done Lance. Quality. One thing on the Met study and exercise: this was aerobic exercise only. Walking and weight training have little negative effects on met or the other.
Thanks for sharing!
Thank you for this info. For people who suffer from exercise intolerance (ME/CFS) who need to avoid the aerobic state as much as possible, this is good news, that metformin is okay with the very light walking and weight training some of us can tolerate.
Confused - are you talking aerobic or anaerobic exercise? Walking is definitely aerobic
I was classic metabolic syndrome despite losing a lot of weight. Berberine has stabilised my fasting blood sugars so I'm very excited about it
Another amazing video. Thanks!
Glad you enjoyed it!
I do think you'd be a great doctor! The way you explain yourself is excellent! Thank you!
You're always great Lance
Thanks
I started taking Lipo Berberine 6 weeks ago. As a side note my limp and stiffness from my osteoarthritis went away! I actually had to Google the two to read some promising papers on Berberine efficacy in osteoarthritis. I take only one 150mg Lipo Berberine/day- Renue By Science. I’m thinking this Liposomal delivery system is more bioavailable. I just know I can walk normally again.
Ian sane , ive just been diagnosed with osteoarthritis im glad i saw your post and will ask my dr about this .
Oh I need joint relief! Will try!
uau !!
@@sandrah6321 I would be very surprised if your doctor knows anything about it. If he does he's a rare one- most of the MDs are just not trained in the nutrition/ natural practices.
YEAH YOU!!! GREAT TO FEEL GREAT!!! I AM 73 AND ROCKING IT! I went for whole food plant based to carnivore next day! Wowza! 16 ozs. of meat, sardines, eggs/butter a day c with one "guest" vegeatble. I will nerver willingly go back to vegan again. I knew upon first bite when I actually felt my body respond to the nutrients missing from my diet so long (only respond to whole food scorced...not to supplementation) 180° change from one day to next apparently triggered an xenobiotic obsenegen dumping from lipids I call the GREAT RENEDERING akin to what happens to bacon. Wiyhing less then 6 days I went from a 22 pant size to a 2-4...like stepping out of a sumo wrestlers fat suit costume...w/in days I stepped out tiny me! Wilder still by day 3 all my inner organs were compression bruised by sooo sudden viseral fat shrinkage. Beyond bizzare. I have been flouritoxic from birth I now know. It's highest electonegativity has squirred with lots of stuff since flouride is the #1 chemical antigonest to the body's master antioxidant...GLUTHIONE. Lordy! It is a YEAH ME for me too. Decade's journey. Whew! Am I blessed to have recovered my cognition/wit & wherewithal and/recouped my abilities. I am Rockin it now!
I take metformin and berberine. My doctor recommended it because I don't want to take a statin for cholesterol. I'm having some stomach problems. However, I see that this berberine is working and I would rather take it than metformin.
Hi Lola. Do you mind sharing your LDL numbers before and after Berberine supplementation?
Great job on the video.
This was very helpful. Thank you!
You're welcome.
Lance...
I am so impressed with this presentation
Naturopathic doctor here... et al
thumbs up - shared and Hit that Bell!!
I will be following you...
Thank you
Love In The Light of God!
I definitely thought berberine had similar effects on exercise similar to metformin thank you for clearing that up.
I don't think it's necessarily a done deal, that's just the best info I could find.
Berberine above metformine in my case. But I'm not diabetic. Don't take Berberine on training days.
Thanks for endless and for ever for you and your lovely video London
So imformative-Thank You 🙏
You're most welcome.
Absolutely fascinating! I have been taking Berberine for about a year. The prescription drugs for type 2 diabetes made me feel awful and I had been taking them for years, when it reached the point where insulin was mentioned, for me it was a step too far. I decided to try Berberine and I now feel so much better. I am not sure that Berberine works as quickly as prescription meds and I have no one to consult with regarding dosage, long term etc. But I feel so much better! A word of warning though, I desperately need a new hip, have been told they won't operate if I am taking Berberine, I will have to stop taking it for at least a week prior to the operation and I know my blood sugar will rise to a point where they won't operate anyway. I am 68 and live in the UK.
Keto
Reason why it makes you feel better is because prescription medication has chemicals added to them
Good anecdotal experience, thank you
What was the issue about berberine and surgery?
Should only take BERBERINE long term for 6-8wks anyway then need to give it a nice long break or may affect liver.
BERBERINE supposedly helps the Hba1c which supports weight loss. Whilst Metformin doesn’t affect the Hba1c. Just do the NO CARBS (no sugar, pasta, rice, potatoes, bread) for that week. I had to go off Hormone Theraphy (HRT) before a hysterectomy. To control my sugar they gave me a shot of insulin in hospital one or two times before surgery if memory serves me right. My sugar level was approx 10 when I had the surgery but that’s maybe an Australian number.
As berberine can elevate insulin sensibility it also means that it could elevate creatine assimilation, which is also a bonus on fitness and longevity status.
There you go.
you think? There are so many women out there still eating meat because they cannot metabolize carotene
Don't use Berberine on workout days.
@@Magic0165 Why ?
@@Magic0165 Why not after the workout, it should not impact it since it has a half life of 4 hours
Really practical insights. Thank you
You're welcome.
Great information. Thank you.
Thank you for the great video! You're very smart and make it easy to understand!
Glad it was helpful!
@@LanceHitchings Thank you Lance! Life saving! You're a genius! I'm so grateful I found you. I'll follow ever video you post. I own a dietary supplement company and would like to partner with you on some things if you are interested in the future.
@@perfection4all Absolutely! I'm thinking of all kinds of ways to expand my business. This is all a ways off, but definitely something to think about. I collaborate all the time.
I've taken Metformin for five years. The ER was recalled due to causing cancer. I got cancer from this. I'm in the process of litigation as we speak. I was taking 1500 mgs per day.
Very sorry to hear that. If I may ask, what type of cancer ? Are you now taking the regular Metformin. Best wishes.
@@ibberman REGULAR Metformin! Get off that shit
@@michaeljackson2838 Oh, OK then.
Some batches of _contaminated_ metformin were recalled. Metformin itself is not carcinogenic. Very sorry you got cancer, and good luck to you.
@@KM-pm6qe Apparently back in 2020, it appears it has happened again in 2022. All from India, same contaminant NDMA.
Thank you for the excellent info and analysis.
You're more than welcome.
Thank you Lance,great infos.
You're welcome
Another well done vid....thanks for all your hard work putting this stuff together.
Glad you enjoyed it
Definitely a good summary of the information. Expressed clearly.
Thanks
Brillant share! Thank you.
Metformin on rest days as far from exercise timewise (24h at least), and Berberine on training days. Berberine is, unfortunately, very expensive compared to metformin (10 times more), over here, so taking only berberine is not viable for me right now.
To reduce side effects from Metformin, you should supplement with B12, folate and NAC. As for the stomach problems, by not taking it daily, switching it out with berberine, your gut gets time to recover. Also prebiotics and *soluble* fiber (oatfiber for example) supplements will help.
That's a great idea for those of us on a budget. Thanks for the tip.
Thanks for the tip. I am going to start on Berberine capsule 500g on empty stomach in the morning and exercise and wait to have late breakfast.
@@mariammathew7435 Nausea is said to be more likely if you take berberine on an empty stomach. But (according to my N.D.) taking it on an empty stomach is usually for the antibacterial benefits, so if you don’t need that feature, you may not need to take it on an empty stomach. Good luck!
I'm going to try this! Thanks
@@michaelblodgett4704 This is an old post. I only take Berberine nowadays. It has more benefits than Metformine does.
I want to hear more about the longevity side of this
I prefer to take something that's been around for 3000+ years and doesn't require a precscription. Thanks for the info! Got my berberine today :-)
What you said is interesting my husband and I were just randomly Dr Google searching the Internet for information about furthering - he’s recently been diagnosed as a diabetic and is taking Metformin - we have recently both started going to the gym about two months ago - my games at the gym is significantly more than what his are - and he was complaining why he was not seeing any results at all even though he is training quite hard - significantly no significant change in his weight - that’s why we were looking at berberine - thank you for this information and we may just do our own little experiment where we go on blabbering see if myResults improve and see if he has any improvements in his body weight and blood sugar. - Thank you for the information keep doing great work.
wowwwwwe finally i found what i asked before noboday can explain like you thank you❤
Has there been any studies taken both METFORMIN and BERBERINE at the same time? That would be interesting to see what the studies show.
Amazing video. Wish it was a written article so I could have my highlighter and notepad. Very informative. Keep up the great work. And Thank You!
Very good run-down!
thanks
Lance Hitchings - Great, very clear, understandable video. Thank you. Question on another topic: Do you do blood flow resistance training, by any chance, and if so how long did it take to achieve results? I am considering it. You look very fit.
I'm not familiar with blood flow resistance training, I'll have to look it up. I just do regular resistance training.
BFRT seems to have evidence behind it. I was looking for a physical therapy clinic and saw that Athletico offers PT sessions that use them. I just want someone to show me how the bands are placed & a video won't help b/c no feedback.
I started Berberine 500 mgs. for neuro-Lyme, since it is reputed to be able to kill the pathogen. It dropped my pulse to 40 bpm, and though I stopped taking it right away, it took me 3 days to recover, during which time I could barely walk from one room to another. On the off chance that it was a freak occurrence, I waited 3 weeks and tried it again, with the same result. Like you say, it has great promise, but be careful since we don't know that much about it.
Thank you for getting this info out there! While I’m a Nurse, I prefer anything more homeopathic in nature, not a fan of big Pharma. While some prescription meds are a necessity esp if the are life saving for immediate use.
I''m with you. Not a big fan of taking a lot of drugs as a lifestyle, but agree. Sometimes they're necessary for life saving.
You sure you meant homeopathy? Or naturopathic?
Is there any medicine for T2D in homeopathic??
That thumbnail image was gold.
Yeah, I wish I could come up with thumbnails as good as that one for all my other videos. 😀
Well done presentation. Thanks!
You're welcome.
I've been taking berberine and chromium and it is doing fantastic but I also do woe which is eating basically only real food you know what our earth provides and I'm feeling so much better
Seeing I can't get a prescription for Metformin, I take berberine.
The thumbnail is everything
Thanks! I probably spent more time on that thumbnail than any other, and it's far and away my best performing video. The thumbnail or the content?
Many thanks for your brilliant efforts. My question is: can one consider taking a little bit of both berberine and metformin?
Great video Lance, as you say, still more questions than answers :-(
Thanks, Vince. Yeah, we definitely need a lot more research.
Lance,
You're an excellent speaker. I really liked this video my friend, excellent work.
Here's my opinion. I feel "almost" everyone above the age of 40 should consider taking Metformin and NOT berberine. Note: I've been taking Metformin for about a year now however, I took berberine for about six months prior to taking Metformin. It's important to note, I'm not a diabetic.
1. Berberine didn't change my blood work much.
2. Berberine didn't change my appetite much.
3. I didn't lose any weight taking berberine.
4. I found it difficult and "chore like" to take berberine because you have to take it 3-4 times per day (not easy to do).
Metformin:
1. My blood work definitely improved significantly especially my triglycerides.
2. My appetite went down. You almost have to remember to eat sometimes.
3. I lost weight (pretty quickly). Went from 270 to 235 within about four months. Note: 235 is a really good weight for me. I went from getting no female attention to having to triage who I wanted to date. Guys, if you're having difficulty getting women, your weight is likely the culprit.
4. I did get loose stools for a few weeks after i began taking Metformin however, it shrank my bloated belly so it wasn't a bad thing. It goes away after a while.
5. It's easier to take (less chore-like). Dose is usually once or twice per day.
Here's a list of the known benefits of taking Metformin. There's probably more so please chime in to this list if I missed something....
1. Lowers bad cholesterol.
2. Lowers triglycerides.
3. Makes the insulin your pancreas produces more effective.
4. Anti-cancer properties.
5. Prevents type II diabetes.
6. Lowers blood pressure (over time).
7. Improves constipation.
8. Reduces your chances of having a stroke or heart attack.
9. Weight loss (less fat storage with more effective insulin, maintaining normal blood glucose levels and lower appetite).
10. Anti-aging properties with AMPK stimulation (still unclear on this particular benefit).
11. Lower cholesterol and triglycerides will likely improve sexual health. Less likely to experience impotence and will definitely allow your ED medication to work better. Triglycerides and Viagra do not mix well. Also, weight loss will help as well. Note: Metformin can reduce testosterone levels so be aware of that.
12. Lower cholesterol and triglycerides can improve eye sight and slow deterioration.
13. Lower blood pressure equals less stress on your kidneys.
14. Decreased depression and anxiety (studies proved this).
15. Improved cognitive function and decreases chances of developing dementia.
16. Improves liver health. Can treat and reverse fatty liver disease via improved lipids.
17. Keeping blood glucose in a normal range and staving off diabetes could prevent gum disease.
Why aren't we all taking Metformin??
That's great to hear, Seth. However, please remember that everyone's different, with different biochemistry. What works for you might work differently on someone else. That's why I feel it's so important for everyone to figure out what works for them, rather than just jumping on board because everyone else is. Glad to hear that metformin work so well for you. Keep up the great work!
@@LanceHitchings
I'm definitely not saying not to take berberine, I'm just pointing out that if you're looking for the benefits of Metformin, you're probably better off taking Metformin and not a weaker substitute. The first two weeks were kind of rough on me. I had borderline diarrhea the entire time which as a field paramedic, it was challenging. But those symptoms subsided fortunately. Some people consider that a side effect however considering most of us are chronically constipated (and don't even know it) I actually consider it another benefit. I mentioned Metformin to my sister who is 47 (chunky, not fat) and she went on it to see if she could reap some of the benefits I've gotten and it's been a miracle for her. Her blood work was always pretty good so she got on Metformin primarily to lose weight and diabetes prevention. She started at 200 lbs and she just told me she's down to 190. Her optimal high school weight is 150. She says her appetite has significantly changed and doesn't crave sweets like she used to. There's just so many benefits with very few side effects/risks. And it's very affordable.
Keep the videos going Lance. You're excellent...
Because using a drug, instead of making diet & lifestyle changes isnt a solution, it's a crutch and long term use of Metformin is linked to depression, and dementia.
I believe long term use of metformin has been linked to dementia. Interesting that the opposite indication is also out there.
Thanks for the great information.
Glad it was helpful!
The real issue is making a decision as to WHY you are taking each medication. If the goal is enhancing autophagy, then perhaps adding Met/Berb ONLY during a 3+ day fast is the key. Since the 'current understanding' of autophagy is that:
1. Autophagy is engaged at a higher level during extended fasting,
2. Senescent cells tend to 'gather over time'
3. Intermittent fasting's goal is to 'clear' the senescent cells
Perhaps, normal exercise without met/Berb is the key, and adding in a fasting 'week' (3+ days) during which adding Met to enhance the autophagy effect during that time. We will be able to 'clear the senescent cells' without overly obstructing the effects of exercise during the rest of the non-fasting time.
I'm really thinking about implementing a 5-7 day fast the last week of every month, during which I add back Met at 1.5g/day during that time only. And remove it from my daily regimen. Theoretically, I'd gain the benefit to autophagy from both actions. The question I then have is should I do the same with Fisetin/Quercetin.
wouldn't extended fasting and using Met drop your blood sugar too low? seems extreme?
Wow isn't a year a long time! Since I commented below, I found myself with a diabetic foot ulcer and was in a bit of trouble. My issue was that even though my numbers seemed OK, the damage was done. Now on Berberine and dealing with the ulcer with the help of a hospital podiatry clinic. MRI for infection testing, blood tests (3) all come back good though. Plenty to consider but importantly now on Berberine and it seems to be keeping things under control. Diet and exercise alone as it would seem need a helping hand if you get it late! Thanks to the Australian government for the free health care as well.
Which brand and level of dose are you on as BERBERINE doesn’t really do anything for me?
@@tigressnsnow It's called Berb-Evail. It is available in Australia in health stores, but you need a prescription. Really works for me. BTW foot completely healed
@@michaeljackson2838
Glad to hear and thank you.
@@tigressnsnow BTW 2 capsules 3 times a day.
@@michaeljackson2838
I’m seeing my doctor tomorrow. Seems he has to register with Designs for Health Australia first. Don’t know how keen he will be to do that? He had me taking Ozempic but had no idea of side effects or how it worked. He didn’t believe me when I told him it holds onto waste matter to give you a full feeling and I have an umbilical hernia so a really bad idea. I did a simple Google search on Ozempic and found how it works. That was just one thing it does. It also restricts the oesophagus. It’s quite evil. It basically wants people to stop eating.
Solid video. I’ve been looking into Berberine and a glucose disposal agent in conjunction with calorie restriction. Like the sound of the short half life as well as potential athletic enhancements.
🐀 stay tuned
Just out of curiosity, is that glucose disposal agent acarbose? I'm doing a video on that soon.
@@LanceHitchings I used GlycoHD by muscle tech. I noticed some headaches while on this supplement regime so I discontinued; however, there’s an abundance of ingredients so really hard to put the finger on a culprit.
I’m going to try light exercise after my morning breakfast to manually regulate faster glucose to muscle uptake, probably the healthier option anyways. Also “The Glucose Goddess” trick to put clothes on carbs worked well for me, so that’s another interesting finding. Although post HIIT I will take carbs laden in fructose and sucrose for immediate muscle absorption, but in healthy moderation.
This is one of the most comprehensive assessments of these two products. I am an extremely insulin resistant diabetic who eats about 20-30 g carbs daily and exercise 6 times a week. I pretty much eat green leafy veggies and organic meat with a hand full of berries. My blood sugar is very hard to control and I can not get my A1C under 6.6. I have lost 50 pounds over the last year and working on my next 50. Is there anyone else out there like me?
Hi, yes, I am not nearly as disciplined as you and have never got my numbers down, however, (and beside the fact that your 6.6 doesn’t sound too bad to me), I have heard from sensible and knowledgeable people, that the numbers (regarding health) are just a guideline and no one truly knows which numbers are exactly right, and numbers once considered healthy years ago have us all freaking out. One health guru said regarding blood sugar levels that even if they appear to be a bit high, it is more important that they do not have rollercoaster ups and downs. I noticed that the only time my levels get to “normal” is after I have had a dessert, so it is a false indicator.
It seems to me that you are doing a great job with your health, and exercise is a major factor. I am happy if I feel well, and don’t have the awful developments of T2D, and I have researched enough about nutrients in food (intermittent fasting) and supplements to keep my brain function (as far as I know, others might disagree). I am still studying about drugs. They don’t put a label on them to say what is in them, so we have to depend on this type of information, for which I am grateful!
I rely majorly on my Faith, and look forward to having a brand new body in the next reality, as this one is getting pretty worn out. If that don’t sell the Gospel, what will?! Blessings from Canada 🇨🇦
@@kathyjames9250 💗. Here is to great health! We can do this.
I pull my hair out with these studies ! 😀