Neuromuscular Junction, Animation

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  • Опубліковано 26 лис 2024

КОМЕНТАРІ • 147

  • @Alilamedicalmedia
    @Alilamedicalmedia  Рік тому +11

    Love this video? Check out our course “Anatomy and Physiology” made entirely with videos like this (without watermark): www.alilaacademy.com/courses/anatomy-and-physiology-for-teachers

  • @syedwaqasalishah1652
    @syedwaqasalishah1652 7 місяців тому +14

    Watching Alila's leactures since class 9th but Understanding it now in mbbs 1st year 😅

  • @Fearlessforthecross
    @Fearlessforthecross Рік тому +325

    Watching this 10 mins before my Physiology exam, wish me luck

  • @shelbywalcott502
    @shelbywalcott502 3 роки тому +40

    This video amazing! As a medical student studying for an upcoming test, this video saved me plenty of time on the whiteboard. I've never seen an explanation as comprehensive as this one, thank you so much.

  • @SOSO7539
    @SOSO7539 4 роки тому +70

    Alila videos are honestly the most understandable, best explained and well animated medical videos on youtube. Always my go to source for clarification. Im still a student so I dont make a lot of $$ but I will support u guys on patreon because this content is why i consider youtube to have some pretty great content (among all the useless timewasting shit that I indulge in as well from time to time :D)

  • @danielacastillo8982
    @danielacastillo8982 4 роки тому +31

    amazing, exactly what I was looking for. Other videos don't explain it like this so thank you!

  • @jeevanandhams3198
    @jeevanandhams3198 4 роки тому +15

    Wonderful explaination thank you

  • @DM-ek2sk
    @DM-ek2sk 4 роки тому +3

    This channel is AMAZING

  • @IKRAMIKRAM-d9h
    @IKRAMIKRAM-d9h 10 місяців тому +2

    Thank you, you explained it perfectly🎉

  • @pharmacysupreme5629
    @pharmacysupreme5629 4 роки тому +7

    Incredible ! Thanks a lot for making this video.

  • @w0rtexn128
    @w0rtexn128 2 роки тому

    first year med student here thanks a lot this helped me aspecialy when all the clases are online

  • @Rian-fg6bf
    @Rian-fg6bf 4 роки тому +2

    Otot rangka berkontraksi hanya jika dirangsang oleh impuls saraf dari neuron motorik.
    Akson dari neuron motorik biasanya menghasilkan banyak cabang, memasok banyak serat otot. Serat ini merupakan unit motorik. Unit motorik kecil ditemukan di otot yang memerlukan kontrol lebih baik, misalnya otot yang bertanggung jawab atas gerakan halus mata. Unit motorik besar terdapat pada otot yang lebih besar yang membutuhkan kekuatan, seperti otot lengan dan kaki.
    Kekuatan kontraksi otot ditentukan oleh banyaknya unit motorik yang diaktifkan pada satu waktu. Bahkan saat istirahat, sebagian besar otot berada dalam keadaan kontraksi parsial, yang disebut tonus otot, yang dipertahankan dengan aktivasi sejumlah kecil unit motorik secara bergantian.
    Hubungan antara neuron motorik dan serat otot disebut sambungan neuromuskuler, yang pada dasarnya adalah sinapsis kimiawi antara terminal saraf dan area khusus membran sel otot yang disebut pelat ujung motorik. Ketika potensial aksi mencapai terminal saraf, itu menyebabkan pelepasan neurotransmitter asetilkolin ke ruang sinaptik. Asetilkolin kemudian mengikat reseptor nikotinik pada pelat ujung. Reseptor nikotinik adalah saluran ion berpagar ligan. Setelah mengikat asetilkolin, mereka terbuka untuk memungkinkan natrium memasuki sel, mendepolarisasi membran sel, menghasilkan apa yang disebut potensi pelat-ujung.
    Potensial aksi dihasilkan dalam sel otot hanya ketika potensial pelat-ujung mencapai ambang yang diperlukan untuk mengaktifkan saluran natrium berpagar tegangan yang terletak di luar pelat-ujung, di membran tetangga. Ketika diaktifkan, saluran ini memungkinkan masuknya natrium lebih cepat, depolarisasi lebih lanjut dan akhirnya membalikkan polaritas membran sel. Pada titik ini, saluran kalium dengan gerbang tegangan terbuka untuk memindahkan kalium keluar, dengan cepat mengembalikan tegangan membran ke nilai istirahat aslinya.
    Setelah dihasilkan, potensial aksi menyebar seperti gelombang berkat saluran ion berpagar tegangan serupa yang terletak di seluruh serat otot. Potensi aksi juga mengalir jauh ke dalam serat melalui tubulus-T, untuk mencapai retikulum sarkoplasma. Di sini, ia mengaktifkan saluran kalsium dengan gerbang tegangan, melepaskan kalsium dari retikulum sarkoplasma ke dalam sitosol sel otot. Kalsium kemudian memicu kontraksi otot dengan "mekanisme filamen geser". Mekanisme ini dijelaskan di video lain.
    Komponen penting lain dari sambungan neuromuskuler adalah enzim asetilkolinesterase. Enzim ini menghilangkan semua molekul asetilkolin yang tidak segera mengikat dengan reseptor dan yang dilakukan mengaktifkan reseptor. Tindakan enzim pada dasarnya menghentikan aktivasi sinaptik, memberi waktu otot untuk rileks, dan dengan demikian mencegah kontraksi terus menerus yang akan mengakibatkan kejang otot.
    Zat yang menyebabkan kelemahan otot atau kelumpuhan melakukannya dengan mengganggu fungsi sambungan neuromuskuler:
    - Toksin botulinum mencegah pelepasan asetilkolin dari sisi sambungan presinaptik.
    - Beberapa racun lain menempel pada reseptor nikotinik, menghalangi pengikatan asetilkolin, tetapi tidak membuka saluran ion.
    - Obat-obatan tertentu masuk ke saluran reseptor nikotinik, menghalangi jalannya natrium.
    Semua zat ini mencegah aktivasi sel otot dan menyebabkan kelumpuhan lembek.
    Di sisi lain, beberapa pestisida menghambat asetilkolinesterase, mencegah degradasi asetilkolin, menyebabkan aktivasi otot secara terus menerus. Begitulah cara mereka menyebabkan kejang otot dan menyebabkan kelumpuhan kejang.

  • @hctam.98
    @hctam.98 4 роки тому +10

    Hope to see next videos from you. Very helpful and easy to understand!

  • @Dr-Hafsa12345
    @Dr-Hafsa12345 Рік тому +1

    love the video and lots of appreciation to your efforts keep doing

  • @potato4033
    @potato4033 7 місяців тому

    This is super well explained! Thank you!

  • @elizabethnashed
    @elizabethnashed 2 роки тому +1

    I have been looking for a good video that shows the main idea and thankfully I ran into this video. Thanks sooo much!!!

  • @RoyalDrawer-i4g
    @RoyalDrawer-i4g Місяць тому +1

    why was number three blurred when it was describing the Neuromuscular Toxins? 4:26

  • @the_farhad91
    @the_farhad91 4 роки тому +4

    We love ua videos.....help us a lot....thnkxxx

  • @emantamer5624
    @emantamer5624 Рік тому

    The best animation and explanation I’ve ever seen ❤

  • @sherlockholmes2167
    @sherlockholmes2167 4 роки тому +83

    I did not like this, I BASICALLY FELL IN LOVE! What can i say? THANKS SO MUCH!!!

  • @WhoDat1345
    @WhoDat1345 Місяць тому +1

    I wonder if emfs can work like a beta blocker for a muscle relaxer

  • @esraaalnaqeeb4811
    @esraaalnaqeeb4811 3 роки тому +7

    This is exactly what i needed !!!!!

  • @jasperk5562
    @jasperk5562 Рік тому +1

    Beautiful explanation, thank you

  • @Zarianimation-u2r
    @Zarianimation-u2r 3 місяці тому

    Great and very clear explanation , a thousand thank you

  • @sauravkadam5560
    @sauravkadam5560 Рік тому

    More than perfect. Nicely explained🔥

  • @whatitmeanstobeJENNIFER
    @whatitmeanstobeJENNIFER 3 роки тому +4

    I had hard time learning this but this 5min video I watched before my exam was it thank you so much
    It really helps

  • @RCHDproductions-db7eh
    @RCHDproductions-db7eh 3 місяці тому

    ❤❤ for the video, 🎉🎉 for the channel owner.

  • @emmanuelsson7941
    @emmanuelsson7941 Рік тому +2

    This was super useful thank you so much for all the help! I was having a hard time understanding the process.

  • @myface4599
    @myface4599 3 роки тому +1

    Thank you. This video is really helpful.

  • @everydaystoriesanimated2318
    @everydaystoriesanimated2318 4 роки тому +3

    *Love Your Video keep doing this 👍🙏🙏🙏😎*

  • @sanaabuomar2939
    @sanaabuomar2939 3 роки тому +2

    This video is really useful for me, thank you

  • @ObertyMwiinde
    @ObertyMwiinde 13 днів тому

    Now I can proudly say I understand and ready to explain when asked

  • @grol477
    @grol477 Місяць тому

    This is super useful thanks

  • @chanppang
    @chanppang Місяць тому

    thank you for saving me!!!

  • @edis9493
    @edis9493 4 роки тому +3

    Well explained. Thank you kindly.

  • @seanbedel7694
    @seanbedel7694 Рік тому

    This is my favorite video

  • @asadurrahman1563
    @asadurrahman1563 4 роки тому +2

    Beautiful presentation. Many many thanks for this wonderful video...

  • @choykage26
    @choykage26 2 роки тому +1

    whoa! that a lot of information ins uch short video. thanks

  • @MaitribaJadeja-wg4fp
    @MaitribaJadeja-wg4fp 2 місяці тому

    Thank youuuu sooo muchhhhh it was very much helpful your videos helped me understand it

  • @Habe111
    @Habe111 4 роки тому +5

    very informative, thank yo so much

  • @mdabusufiansarker6916
    @mdabusufiansarker6916 3 роки тому +1

    Many many thanks....

  • @Dr_Asma_physio
    @Dr_Asma_physio 4 роки тому +1

    Exactly what I was looking for.. thanks alot..helped too much

  • @marissalowder3140
    @marissalowder3140 2 роки тому +1

    Greatly explained

  • @Onesimo_Mahlaba
    @Onesimo_Mahlaba 3 роки тому +1

    Thank you so much❤

  • @OLATOSIN-fv4hu
    @OLATOSIN-fv4hu 3 місяці тому

    Exam in few days thank God I come across this channel before my exam

  • @sabeensikandar4778
    @sabeensikandar4778 3 роки тому +2

    It was really helpful 👍

  • @raghad7131
    @raghad7131 4 роки тому +1

    Thank you so much

  • @thestar9563
    @thestar9563 4 роки тому +2

    Excellent !!!!

  • @مؤملمحمد-ن3ض
    @مؤملمحمد-ن3ض 3 місяці тому

    Wow that was amazing 😮😮

  • @physiciansmind
    @physiciansmind 4 роки тому +1

    Awesome video!!

  • @kayceegemaol8727
    @kayceegemaol8727 Рік тому

    Perfect explanation! Thank you :)

  • @refapramadhika8720
    @refapramadhika8720 4 роки тому +1

    OMG thank you very much

  • @Farhan-co9he
    @Farhan-co9he 4 роки тому +2

    very nice

  • @hazel8537
    @hazel8537 Рік тому +1

    Where the potassium ions located

  • @Milousra8376
    @Milousra8376 2 роки тому

    Thank you so much ❤️❤️❤️

  • @Candra-me7fu
    @Candra-me7fu 2 роки тому

    thank you for this video

  • @rensarea
    @rensarea Рік тому

    Thanks a lot!

  • @urielmelnakila5829
    @urielmelnakila5829 Рік тому

    very reliable very insightful says my friend

  • @KARMlCd3bt
    @KARMlCd3bt 2 роки тому +2

    AMAZING

  • @shehnazmalik8809
    @shehnazmalik8809 Рік тому +1

    Amazing

  • @mahfouzmiftah
    @mahfouzmiftah 3 роки тому +4

    1:31 neuromuscular junction

  • @jcdenton9386
    @jcdenton9386 7 місяців тому

    There seems to be a mistake during 2:36, when talking about bringing the voltage back to its resting potential, truth is, no hyperpolarization should occur. The voltage doesnt go below -95V.
    Otherwise great vid Alila, hopefully people didnt fail based on that mishap.

  • @MouayadGhrewi
    @MouayadGhrewi 11 місяців тому

    Amaaaaaazing

  • @DrSaja-ym6lj
    @DrSaja-ym6lj 3 роки тому +1

    thank u very much 🌼🌼

  • @aidanmccauley3776
    @aidanmccauley3776 Рік тому

    perfect for my AP bio

  • @duaaeltayeb8652
    @duaaeltayeb8652 2 роки тому

    That was very useful, thank u 💜💜💜

  • @mohanoorislam7696
    @mohanoorislam7696 3 роки тому +1

    Very helpful for me ,,done

  • @medicallifewithjohn
    @medicallifewithjohn 4 роки тому +2

    Thanks

  • @Nick-nv1mk
    @Nick-nv1mk 6 місяців тому +1

    What is #3 at 4:10?

  • @joshuasaetern8069
    @joshuasaetern8069 2 роки тому

    Beautiful.

  • @rambles2727
    @rambles2727 Рік тому +1

    What was the 3rd toxin

  • @onyxoxo
    @onyxoxo 8 місяців тому +1

    im so fucking fumb bc the comments are saying this is so well explained and i dont understand SHIT

  • @karaiver1663
    @karaiver1663 3 роки тому +3

    why is the no 3 censored?

    • @Alilamedicalmedia
      @Alilamedicalmedia  3 роки тому +1

      A mistake.

    • @maxdolphin984
      @maxdolphin984 2 роки тому

      @@Alilamedicalmedia Could you kindly add some examples of those drugs (inhibitors / blockers) of sodium channels in postsynaptic receptors? Thank you.

  • @safaa4809
    @safaa4809 Рік тому

    Amazing!!

  • @user-ts3cn8sk7r
    @user-ts3cn8sk7r 2 місяці тому +1

    مافهمت وش ترطن إذا عندكم مقطع بالعربي هيلب

  • @Keepdreaminnggg
    @Keepdreaminnggg 2 роки тому

    this was so helpful whoa :)

  • @Lisdaisie
    @Lisdaisie 4 роки тому +1

    Please create video about biochemistry

  • @fauzananugrah1721
    @fauzananugrah1721 3 роки тому +1

    you save me thanks a lot

  • @mehreenn
    @mehreenn 10 місяців тому

    4:24 what is the blurred one?

  • @muhammadahmed7976
    @muhammadahmed7976 3 роки тому +1

    Thanks a lottttttttttt🥰🥰🥰🥰

  • @SuccessMindset2180
    @SuccessMindset2180 2 місяці тому

    When there is action potential there is muscle contraction

  • @Dr.Waleed
    @Dr.Waleed 2 роки тому

    greaaaattttttttt video thank you

  • @النسرالجارح-ب6و
    @النسرالجارح-ب6و 2 роки тому

    Great✨
    Thx

  • @coconut7339
    @coconut7339 8 місяців тому +1

    Watching this vid tonight because we have a quiz tomorrow 😭

  • @ashaevangeline2316
    @ashaevangeline2316 2 роки тому

    Best vedio ♥️

  • @cute_girl5508
    @cute_girl5508 3 роки тому +1

    What is mean by cytoplasmic

    • @hazel8537
      @hazel8537 Рік тому

      Mucous membrane btw the cells

  • @FatimaAlawadi-ib2tw
    @FatimaAlawadi-ib2tw 6 місяців тому

    شكرا لك ياحلوتي❤

  • @s.harishs.harish8791
    @s.harishs.harish8791 2 роки тому

    The information is very well please improve conversation voice to be understand for all person... Because of everyone watching this from several countries will areas like I am from India Chennai Tamil person but I can understand English but it could be more specific way of talking is more space please try to explain for my kind of persons in formal English this is my own request thank you

  • @elisse9396
    @elisse9396 3 роки тому

    EDIWOW MAAM KATARAKA

  • @KuyaRenztv-r3e
    @KuyaRenztv-r3e Рік тому

    Stelleton to love

  • @draconicproductionsinactiv5717
    @draconicproductionsinactiv5717 4 роки тому +1

    I found lag in 3:01

  • @prathamacharya8902
    @prathamacharya8902 Рік тому +4

    Save me from physiology exm

  • @ARMY_Bangtan247
    @ARMY_Bangtan247 8 місяців тому

    Studying for Bioelectricity, only 1 day left before the exam

    • @ProCircle-s8m
      @ProCircle-s8m 3 місяці тому

      Do Yu understand this bro

    • @ARMY_Bangtan247
      @ARMY_Bangtan247 3 місяці тому

      @@ProCircle-s8m Ya now I do. The video has described it in the easiest way

  • @ondrejhorsky2737
    @ondrejhorsky2737 2 роки тому

    Hi

  • @the.shree_21
    @the.shree_21 3 роки тому +2

    👌👍

  • @codrut913
    @codrut913 2 роки тому

  • @turkersoykan5695
    @turkersoykan5695 4 роки тому +2

    🙏🏽❤️

  • @عبدالحميدلحنالحياة

    What do you think we work together?
    I work with Arabic voiceover
    There are many Arab followers, and this facilitates the transfer of information, communication, and increasing the channel's followers

  • @anthonyphoenix393
    @anthonyphoenix393 7 місяців тому

    English pls

  • @kahlesoon9653
    @kahlesoon9653 3 роки тому

    1:30