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One of the best explanations I could find. I was really confused about the pumps and refractory periods but now I understand what my text book is trying to explain.
As an engineer I couldn't find a satisfactory edplanation on depolarization; thanks to this video It now makes much more sense. Thank you and keep up the good work!
0:18 ACTION POTENTIAL: A brief reversal of electric polarity across the cell membrane. 0:44 RESTING MEMBRANE POTENCIAL RMP (neuron): -70 mV (cell is more negative in the inside.) 1:23 A neuron is typically stimulated at dendrites and the signals spread through the soma. 1:28 DEPOLARIZATION: Excitatory signals at dendrites open ligand-gated sodium channels and allow sodium to flow into the cell -> makes membrane voltage less negative. 1:49 Influx of sodium produce a current that travels towars the axon hillock. 1:49 If the summation of all input signals is excitatory and strong enough when it reaches the axon hillock -> action potencial is generated (travels to the nerve terminal). 2:08 Axon hillock: "trigger zone" (where action potential usually starts -> voltage-gated ion channels concentrated). 2:27 Voltage-gated ion channels open at some values of the membrane potential and close at others. 2:45 THRESHOLD: -55 mV -> Minimun required to open voltage-gated ion channels -> action potential generated. (Na+ channels open quickly / K+ channels open slowly) 3:07 As sodium rush into the cell, the inside becomes more positive (depolarization). 3:18 The increasing voltage in turn causes even more sodium channels to open (positive feedback) -> Rising phase of the action potential (polarity reversed). 3:37 As the action potential nears its peak, Na+ channels begin to close -> K+ channels are fully open. 3:47 K+ rush out of the cell -> voltage returns to its original resting value (falling phase of the AP). Na+ and K+ have switched places across membrane. 4:08 HIPERPOLARIZATION: Negative overshoot (K+ gates close slowly -> K+ continues to leave the cell a little longer). 4:15 RMP is restored thanks to diffusion and Na+/K+ pump. 4:34 REFRACTORY PERIOD: During and after shortly and AP is generated, it is impossible or very difficult to stimulate that part of the membrane to fire again. 4:40 ABSOLUTE REFRACTORY PERIOD: from the start of an AP to the resting membrane value. -> Na+ channels are open and then inactivated -> unable to respond to any new stimulation. 5:00 RELATIVE REFRACTORY PERIOD: Lasts until the end of hyperpolarization (K+ channels still open) -> difficult to membrane to depolarize. 5:38 El potencial de acción se propaga solo en una dirección (debido a las propiedades refractarias de los canales iónicos). 5:41 Solo la zona no activada del axón puede responder con un PA; la parte recién activada no responde hasta que el PA esté fuera de su alcance. 5:53 An action potential generated at the axon hillock usually travels down the axon and not back to the cell body.
Absolutely relieving! Great explanation that was clear and unlike every other explanation, not too many extremely complex words were used in one sentence which is the giving up point for most people. Thank you
Thank you for your comment. In fact many universities and colleges use our videos for lectures and on their online learning portal. You can certainly suggest to your teachers :)
I have been struggling for weeks and in just a few minutes you have eased my understanding of this specific process. You have given me hope to pass my test. I 100% appreciate this awesome video. Thank you! Thank you ! Thank you!
Thanks! My notes were confusing. Couldn't figure out what was happening with K and when it was leaving the cell. 2 hours of reading and struggle solved in 6 minutes. Sheesh! Thanks again!
Zoology is often confusing as we cant do any experiments in human body but you people explained it in such a precise manner that words cant reach to appreciate it. I suscribed your channel One suggestion please pronounce certain words in such a manner so that Indians can also understand.
After watching lots of videos about action potential really when I exhausted that time I decided to watch this last video really this video helps me lot and ur explanation and video just amazing thanks !!!!
This video is really great..I was suffering from a problem with neuralgia, but this video solved it all with all the important information about it, and also in only six minutes..Thank you very much for this 🤍
This lesson was one of the most difficult lessons in school. I did not know anything about it. After watching this video, I became able to solve all the questions on it, even those that are not in my approach. Thank you for this useful video. 🤍💫
@@prateekfaujdar5847 4:06 if the timestamp. Basically, potassium channels are slow to open and close. Right after the falling phase, the potassium channels remain open for a while longer due to which more potassium ions leave the cell. This results in a the cell becoming slightly more negative than what it was in it's resting phase. This is called hyperpolarization. Tell me if it cleared your doubt... 🙂
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For student: www.alilaacademy.com/courses/anatomy-and-physiology-for-students
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NEW: Now you can also get access to our courses with our UA-cam channel membership (Academy Access levels)
remember the word
NOKIA
Na Out K In via Atpase
3 ➡ 2 ➡1
3 sodium out 2 pottasium in with 1 use of atp
Always remember the word 'INK',
I : Inside the Cell.
N : Negative Charge.
K : Potassium.
❤️
👍👍
Ty
Thank you for this so so helpful and easy to remember 🧡
Ok ola hu uber
Yes bish
Literally saved our lives! Explained in minutes what was confusing us for hours. Thank you so much and keep up the great work!
Riddhi Patel u mean mentally
I agree
😬
facts
Actually..!
I just learned a whole week of lecture in 6 minutes. Thank you!
Yup....Mee 2
More like 5 mins of lecture ...
i half fall asleep and half contemplate jumping out the window during class lectures lol
Are you alive
One of the best explanations I could find. I was really confused about the pumps and refractory periods but now I understand what my text book is trying to explain.
😂
As an engineer I couldn't find a satisfactory edplanation on depolarization; thanks to this video It now makes much more sense. Thank you and keep up the good work!
0:18 ACTION POTENTIAL: A brief reversal of electric polarity across the cell membrane.
0:44 RESTING MEMBRANE POTENCIAL RMP (neuron): -70 mV (cell is more negative in the inside.)
1:23 A neuron is typically stimulated at dendrites and the signals spread through the soma.
1:28 DEPOLARIZATION: Excitatory signals at dendrites open ligand-gated sodium channels and allow sodium to flow into the cell -> makes membrane voltage less negative.
1:49 Influx of sodium produce a current that travels towars the axon hillock.
1:49 If the summation of all input signals is excitatory and strong enough when it reaches the axon hillock -> action potencial is generated (travels to the nerve terminal).
2:08 Axon hillock: "trigger zone" (where action potential usually starts -> voltage-gated ion channels concentrated).
2:27 Voltage-gated ion channels open at some values of the membrane potential and close at others.
2:45 THRESHOLD: -55 mV -> Minimun required to open voltage-gated ion channels -> action potential generated. (Na+ channels open quickly / K+ channels open slowly)
3:07 As sodium rush into the cell, the inside becomes more positive (depolarization).
3:18 The increasing voltage in turn causes even more sodium channels to open (positive feedback) -> Rising phase of the action potential (polarity reversed).
3:37 As the action potential nears its peak, Na+ channels begin to close -> K+ channels are fully open.
3:47 K+ rush out of the cell -> voltage returns to its original resting value (falling phase of the AP). Na+ and K+ have switched places across membrane.
4:08 HIPERPOLARIZATION: Negative overshoot (K+ gates close slowly -> K+ continues to leave the cell a little longer).
4:15 RMP is restored thanks to diffusion and Na+/K+ pump.
4:34 REFRACTORY PERIOD: During and after shortly and AP is generated, it is impossible or very difficult to stimulate that part of the membrane to fire again.
4:40 ABSOLUTE REFRACTORY PERIOD: from the start of an AP to the resting membrane value. -> Na+ channels are open and then inactivated -> unable to respond to any new stimulation.
5:00 RELATIVE REFRACTORY PERIOD: Lasts until the end of hyperpolarization (K+ channels still open) -> difficult to membrane to depolarize.
5:38 El potencial de acción se propaga solo en una dirección (debido a las propiedades refractarias de los canales iónicos).
5:41 Solo la zona no activada del axón puede responder con un PA; la parte recién activada no responde hasta que el PA esté fuera de su alcance.
5:53 An action potential generated at the axon hillock usually travels down the axon and not back to the cell body.
Really thanks for this summary ❤
Thanks
@@Unknown-zc2nvits not him who made it its in the description haha
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I shed a real tear watching this video... 10/10 excellent job
this is undoubtedly the best explanation of the action potential!!
Aur bhai aagye yakeen walo...🤣🤣chalo like kardo to +4 pakke
Samapti ma'am kesa samjhati hai?
@@GulsonAraBegum itna ki ye dekhne ki zarurat nai padegi..🤌🔥
This is the most accurate explanation of Action Potential in Neurons .... compared to the other videoeS! thank you!
THANK YOU THANK YOU THANK YOU!!!!! When my professor explained this in class I was so confused but this helped me actually understand it!
A video made years ago just saved me☺️☺️. Alila the best
this is the only video that clearly explains about the action potential. thank u so much💖
Absolutely relieving! Great explanation that was clear and unlike every other explanation, not too many extremely complex words were used in one sentence which is the giving up point for most people.
Thank you
Super explanation....💥Arjuna here ♥️..
The most accurate video I've seen. I wish it talked about sodium's inactivation gate though.
Thank you, we will keep that in mind for future updates.
Michelle Kristen *Hmmm*
THANK YOU SO MUCH! i wish they'd just use these animations for lectures as well, would make our lives so much easier.
Thank you for your comment. In fact many universities and colleges use our videos for lectures and on their online learning portal. You can certainly suggest to your teachers :)
@@Alilamedicalmedia yes!
Our physiology teacher use and recommend us too to watch your videos
Thank you a lot for this animation .It help us to understand neuron work easily@@Alilamedicalmedia
I have a huge Anatomy final tomorrow and this video was just what I needed. Excellent job. Can't wait for your future videos.
why do you lean this in anatomy this is physıology
I have been struggling for weeks and in just a few minutes you have eased my understanding of this specific process. You have given me hope to pass my test. I 100% appreciate this awesome video. Thank you! Thank you ! Thank you!
Glad we could help :) Good luck with your test!
This video is sent from heaven😂
Thank you for this amazing explanation
Best video on UA-cam regarding this topic
Balle balle🕺🕺 samjh aa gya oye😍😍😌😌😌😌😀
One of the best animated mechanism I saw of AP
Well done
Most helpful video I have seen so far. Thank you!
Aagye arjunaaas... 🫠
The best animated explanation ever👍🙏...This short video made my work lighter
Thanks! My notes were confusing. Couldn't figure out what was happening with K and when it was leaving the cell. 2 hours of reading and struggle solved in 6 minutes. Sheesh! Thanks again!
An hour intense class covered in 5min with good animation! Good job..
The topic which took me two weeks to understand is now understanded in just a few minutes.
Ah yes the good ol' Axon ʰⁱˡˡᵒᶜᵏ
Lol
I was looking for this comment, thank you.. I can rest easy now.
Lol
🤣
Amezing animation❤❤
hey u got a new subscriber.....keep up the good work and thanks alot for such an informative vid 🖤
Very well explained with supportive visual animation. Simplified and brilliant. Had to subscribe :-)
I wish I would have watched this video two days ago it would have saved me a lot of headache! AMAZING explanation! Thank you so much :D!!!
wow best video on UA-cam till now 👍👍👍👍👍
This is SO WELL EXPLAINED thank uu
Thank you so much. This is the best video that I have found so far for my class.
شكراااا هواي چنت كلش محتاجة للشرح 😭♥️♥️♥️♥️♥️
Clear all the concepts...thank you very much...🙏🙏🙏
Best explanation ever one can get 👍👍👍
Zoology is often confusing as we cant do any experiments in human body but you people explained it in such a precise manner that words cant reach to appreciate it. I suscribed your channel
One suggestion please pronounce certain words in such a manner so that Indians can also understand.
Besttt video ever😭😭thankk uuuu soooooo muchhh❤️😭😭
Thanq...sooo much...u made it very clear to understand in just few mins...🤗🤗🤗✌️✌️
Samapti Mam op 💗
The best learning channel
Thank you from the bottom of my heart
Awesome work thank you 😃😃😃
Great work! Cleared my concepts finally.
After watching lots of videos about action potential really when I exhausted that time I decided to watch this last video really this video helps me lot and ur explanation and video just amazing thanks !!!!
It's easy to understand due to animation..... thank you so much 👍👍👍
You’re video was a life saver because I have my exam soon and this section always confused me.
Great explanation
Thanks a hell lot of times! This will save me tomorrow
Thank you sooooooo much.you saved my life .please continue to makd videos like this.
Sir, u r a blessing for us students
Omgg..this helped meee i have been studying since 3 hrs...lovelyy..u deserve my subscription:)
You've officially earned a subscriber! Thank you soo much for a great video!
Thanks for watching!
This is what I call a good job!
SAPOLA ARMY ATTENDANCE 💗💗💗
Koi hai jo Sampati ma'am se padhke aaya edhar yakeen 2.0 se 😅😅😅😅
Arjuna
so amazing animation🔥🔥🔥🔥
UA-cam is much better than school undoubtedly
It was so much helpful.... Easy to understand that.... Keep it up champion
You are a real legend like OMG. This literally taught me what i was struggling with.
Thank you
Thanks :)
One of the best explaination i found .....
Nice and useful videos for our class. Thanks!
How hyperpolarisation prevent neuron from another stimulus
This is so clear!Thank you
Very well explained!! 👍👍👍
I finally understand now. Thank you for this.
This video is really great..I was suffering from a problem with neuralgia, but this video solved it all with all the important information about it, and also in only six minutes..Thank you very much for this 🤍
This taught me so much regarding conduction of action potential thnq u so much for sharing 🙏
Thanx for posting this video.It helped me a lot
Best lecture ever
You are blessed inthe name of jesus ameeen❤❤
Wonderfully explained thank you
This lesson was one of the most difficult lessons in school. I did not know anything about it. After watching this video, I became able to solve all the questions on it, even those that are not in my approach. Thank you for this useful video. 🤍💫
Anyone from yakeen 2.0 😂✌️ samapti ma'am ke sapole
Yaah 😅
One more sapola
Hnn g😅
Does she teach well?
It was phenomenal 👌
After my lecture r confusing me i land on this😢😮thx
its really good. Easily understandable. Thank you.
Thank you for watching!
Thank you so much for this. I will forever remember this favour
Please tell how hyperpolarisation works
@@prateekfaujdar5847 4:06 if the timestamp. Basically, potassium channels are slow to open and close. Right after the falling phase, the potassium channels remain open for a while longer due to which more potassium ions leave the cell. This results in a the cell becoming slightly more negative than what it was in it's resting phase. This is called hyperpolarization. Tell me if it cleared your doubt... 🙂
this video was very good to watch
Well explained.Thanks for sharing😍
Thanks for sharing such a Great video dear..... I was very confused but this animation really help me to understand the concept... 👍💕
Excellent explanation, great work!
Many thanks!
Thanku Samapti Mam ❤
this is what we needed.☺
Very nice...perfect for federal student's
This is the way to teach
Thanks dear sir
Anyone doing medical physiology in 2024??🙂
Me 😭
So comprehensive and fluid!! Thank you.
remember the word
NOKIA
Na Out K In via Atpase
3 ➡ 2 ➡1
3 sodium out 2 pottasium in with 1 use of atp
It helped a lot ... Thanks bro...
Best vdo to clr action potential .. thank you..
It is really very very helpful.
Thank you
Excellent! Thank you so much for this Amazing Video!
You are right i like this video perfect understanding
This is sooo helpful. Thank you thank you
Great explanation!! Thanks!