Musculoskeletal System | Neuromuscular Junction | Neuromuscular Transmission: Part 1
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- Опубліковано 2 чер 2024
- Official Ninja Nerd Website: ninjanerd.org
Ninja Nerds!
In this lecture Professor Zach Murphy will be teaching you about the neuromuscular junction, and the neuromuscular transmission. During part 1 of this series we will be discussing the action potentials carried by the alpha motor neuron, and the factors that play a role in the release of ACh, and the synaptoproteins involved with this process. We hope you enjoy this lecture and be sure to support us below!
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![ПОЛНАЯ ИСТОРИЯ ЭКЗОРЦИЗМА [Топ Сикрет]](http://i.ytimg.com/vi/qBySr6Bt0B8/mqdefault.jpg)
As a PhD student in muscle physiology studying and reviewing this stuff in preparation for my PhD defense oral exam, I can say that this information is expertly prepared and presented. Magnificent job here! Really looking forward to the second part.
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Nnn.
I think I will release some Ach into the synaptic cleft to open my ligand gated ion channels to allow Na+ to enter my fiber cells and cause my Ryanodine receptor to open my sarcoplasmic reticulum allowing Ca+ to release and bind to my Troponin- C which changes the shape of Troponin- T causing my tropomyosin to move away from the active site of my actin allowing my myosin to bind to my actin which pulls my thin filaments using power stroke to finally get over one another
Which allows my palm and forearm muscles to contract in a way that moves my finger towards the like button and clicks it...
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Hehe
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you are the only reason i have not felt completely hopeless in properly understanding physiology yet. thank you so much
A struggling medical student here! Your videos are really a big help for students like me. Thank you very much and more power to you!
I’m with you sis! First year medical student and I am so grateful for ninja nerd lectures. I find myself recalling concepts he covered during class or exams. The way he explains is so much easier to grasp than my lectures
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Thank you. I've learned more in the first 7 minutes than in the 1 hour I spent reading my textbook.
As a med student, thank you for these videos. Very in-depth and not "dumbed" down, which I needed, especially regarding the specific proteins!
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Love from India😃🇮🇳
You actually taught me all the material in half an hour while my own prof couldn’t teach them in 12 hours.))) u rock!
Ninja Nerd You are really a Science Talented individual. You helped me to prepare my Neurophysiology exam and I hope this knowledge from you will contribute much towards my future career. Thank you so much for your time and hard work.
A. Godfrey It is EXACTLY taken from Dr. Najeeb Lectures...
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You are incredibly gifted! There are a few people who are natural-born teachers and you are on that list. Thank you very much for your videos- I once despised physio but I find myself so glued, actually enjoying the lecture, and making several connections in my head. You are AMAZING!!!!
I can't thank you enough for these videos! They are such a great reinforcement to my professors lectures and my own readings. It helps me understand the material so much more and I am able to repeat it and teach it back to someone else. Absoutely love this channel as I am a pre-Nursing student going back for my ABSN at age 40!
Me too, but I'm 41! Nice job!! Love this guy...he's so great! 🙂
I've studied this subject for a long time. But it never was as clear in my mind as it is now, after watching this video. Thank you!!!
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I'm here after watching the first two videos on muscle physiology on your channel, but actually, I came here for anatomy of the muscle but I can say this first two video has really helped me more and I understand it more. thanks so much ninja nerd president.
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Starting Advanced Skeletal Muscle Physiology tomorrow morning - and this is a GREAT help! Thanks! :) You are a FANTASTIC teacher!
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Sir you make my concept crystal clear
Hey ! I really love your videos, you're doing an amazing job and I hope you continue to make more stuff. One thing referring to the video: Isn't Syntaptotagmin binding the Calcium and in this way getting free of the Complexin-Protein which usually blocks the bindig of the other proteins? (Synaptobrevin , SNAP 25 and so on ) ? Correct me if I'm wrong :)
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such a good explanation, thank you!
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Take a bow sir. Fabulous explanation.
I'm MPhil student and this subject is my minor subject. I always find this difficult but by these lectures I feel topics easy
This is an awesome help with understanding the physiology of the muscle. Thanks a lot!
Meanwhile everything is happening at the same time. Acetylcholine synthesis is happing while calcium ions come inside the synaptic bulbs. And also acetylcholine is being released by calcium and snare proteins. So everything is happening simultaneously. You explained it really nicely. Appreciate your efforts and hard work for those who don’t get enough medical knowledge from actual school. Hats off 🥳
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Great video, I know understand what the issue was, when I recently had to suddenly call an ambulance for my flatmate, and then in the hospital it turned out he had a lack of potassium, which made his muscles not be able to tense up properly
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Great overview, but what about Calcium-calmodulin and activation of CAMK II which phosphorylates synapsin?
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Tbh I thought this chapter was going to destroy the A I have in A&P but this makes so much sense and is more detail than our textbook
Thank you so much, this was really amazing
great vid, thanks.
which vid has the details of action-potentials, please ?
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Good luck on the exam! - TG
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Hi, I have a doubt. Doesn't the protons move outside the vesicles down it's concentration gradient in the Vesicular Acetylcholine Transporter to allow the Acetylcholine to move in to the vesicles?
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Very detailed and well taught. Preparing for Frcophth part 1
Another great video! When the Na comes in, does the K come out as in the 3/1 ratio, still creating the + charge inside, or in this case is just Na? Also, what inhibits these ion protein channels as we know genetically, such as in CF when the Cl channels do not work, so these are acquired channelopathies. So my 2nd question is, can heavy metals such as Al, Hg, Pb, Cd, and chemicals block or inhibit these ion channels...
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Hoping I'll pass my class : D
Thank you, I finally get it!!! lol
Are alpha motor neurons the only neurons that stimulate muscle cells? In my lecture notes my professor categorizes them as lower motor neurons. Is there anything we should know about other motor neurons such as upper motor neurons as pertaining to muscle stimulation?
+Diana Ferrigno Great question! There are many upper motor neurons that stimulate lower motor neurons. To name a few there is what's called the corticospinal tract, the vestibulospinal tract, reticulospinal tract, and the rubrospinal tract. We plan on making a video on these tracts which are descending pathways. With regards to the lower motor neurons. The alpha motor neuron is the main motor neuron that supplies what's called the extra fusal muscle fibers. There is another type of motor neuron called the gamma motor neuron which stimulates what's called muscle spindles or also known as intrafusal muscle fibers which are important for what's called proprioception which is basically one's understanding of their position in space.I hope that answers your question if there's any confusion just let me know! Best of luck in your studies.
Awesome! Thanks so much for your clarification I look forward to seeing those next videos :)
Genius! keep it up bro!
Near the end of the video, as you were discussing potassium efflux for repolarization, would this relate to how a depolarizing NMBA like succinylcholine work?
PERFECT!
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