It's actually oxidizing (rusting/burning) your organs whenever you take a breath. If you don't eat, your stomach acid can kill you by dissolving itself.
AwsoGlitch lmao this is why I always have CC on, sometimes they have one person assigned to a certain channel like markiplier they always put jokes and comments in () and are so good at subbing him 😂
JoKing I think what they're implying is that they can isolate those certain proteins and block them off. Antibodies for pathogens are made complimentary so blocking off one specific receptor won't be necessarily harmful to the body. Plus I don't think they'd be making a big deal out of this if what they had found out turned out to be worse for your body.
That's why more research is needed, but on it's own this new found bond will help matching organs properly, it's as huge as blood types are to blood transfers imo.
+JoKing - that is actually already the situation. Transplant recipients have to take strong immunosuppressants to help fight their body's attempts to attack the new organ, causing rejection. These drugs also make them very susceptible to other illnesses, that is one of the unfortunate trade-offs. This new information though could lead to more targeted and precise prophylaxis, like something that could prevent the T-cells from getting the message to attack these particular cells, but not messages about other legitimately dangerous bodies. As mentioned in the video, it can also help better match up donors and recipients to reduce the rates of rejection.
As they already said,that's why more research is needed. Plus if you can actually find a match betwen your system and new organ you shouldn't need it since it wont detect it as a foreigner unknown thing
IAMdeathblade Just think about how there's someone out there that couldn't even get a transplant and died. I would gladly take the medicine if it let me breathe another day.
Ayman008 I know what you mean bro am extremely grateful I take care of myself by working out eating good and soon going to be a police officer! Obviously it's better not to ever have to worry about rejection but in the future everything will change for the better!
Ayman008 I don't have words to express how thankful I am for my lungs + heart, but it's okay to express frustration on all the heavy drugs you're on from here on out. These drugs can have big effects. Like diabetes, for example. I wouldn't be alive without my transplant and I owe everything to my donor and their , but that doesn't mean some days are still rough.
My mother just got a new kidney, and the surgeon and doctors is extremely surprised how well her body accepted it. Perhaps it has something to do with that she accidentally matched so well with the snitching cells? I would like to believe so. Also, it would be nice if you also mention the lack of donors all over the world. People are dying while waiting for a new organ..
If your body won't reject the new organ due to adaptive immune system receptor blockage, how is that new organ going to fend off infections or diseases without it?
I liked the video except that dang obnoxious ringing in the background audio. Nothing helps me pay attention to a video more than the repeated ringing of a seemingly far away telephone.
The major problem is that patients stop taking their immunosuppressive medication as required. Even though it is fully paid for by public social insurances in most countries (as is the surgery itself).
Still need more organ donors. Maybe make it universal that person have to declare that they DON'T want be organ donors, assumption being that everyone is willing donor (presumed consent, opt-out). Like the opposite to present situation. Finland and Austria has had this system for many years and i bet there are many more. Instead of having "donor card" in wallet, one would have "Not a donor"-card. Would greatly help with patients waiting organs, sometimes years. Would not solve the issue but alleviate it.
+Ayman008 Hah, that would fun to see :D Any one person, at any time, can and could make it known with simple credit card sized card that says that person does not want to be organ donor. Wording does not matter, as long as it's clear to read during emergency. Even verbal opting out is possible, letting relatives know what person wants if worst happens so they can let hospital staff know how to proceed. It really is simple, it's just a matter of will. And again, anyone can and could say no. Organ doning should never be mandatory. Person should have the last say on what happens to his body. Problem now days is that there are so many people who have not thought of this and when the tragedy happens, no one can say what to do. And because organ doning is a process where there is little time to waste, many people who could have helped, have no chance to help. In my country there was earlier a opt-in system in place so i made an organ donor card when i turned 18. I still carry it in my wallet despite the fact that we changed into opt-out system. It's not needed (perhaps) but it clarifies and removes the hesitation where medical personel has try to find out if person had objection to organ doning. But that's me and this is one suggestion.
+mimi // True, but that sounds like too far into the future. I like Alaric Balthi's idea. I don't know the situation with waiting for organs, but I can easily imagine that a lot of people are neutral to the whole thing and don't particularly care about keeping/losing their organs. It's just that signing up never seems to cross their mind, which this kind of system would address.
Doesn't perfusion decellularization solve organ rejection? remove the cells from the donor organ such that a scaffold that is fully intact remains. Then recellularise with the recipients cells before transplant.
That's still in developement, and with neural links we'll be faster at research, like cancer cures by tomorrow fast. Can't wait until it's made (by 1 or 2 years.)
+pyromancer I doubt we'll see any synthetic organs in the near future. I don't now how advanced the industry is, but organs are complex machines themselves. I think we'd be hard-pressed to synthetically recreate something so elegantly designed.
I thought I was about to learn a new pathophysiological mechanism, but I new this already. Only thing this video taught me was that they were able to narrow it down to the specific Sir alpha antigen
Everybody, please speak up and don't rattle your voice at the end of sentences, called "vocal fry." I am only a little bit hard of hearing , but it makes it harder to understand and isn't good for your vocal cords, either. For example, on the word "cell" in "...another type of immune cell" @ 1:57. Thank you.
As a heart transplant patient that has gone through rejection there is a reason they give you anti rejection meds. They lower your bodies t cell count so that your organ doesnt get rejected, also another reason the organs only last up to 15 years is that they were dead at one point and started to decompose
As far as I know, transplant recipients only need to take anti-rejection medication for a number of years and then they're fine without them. I used to think that the recipient's body eventually accepts the transplanted organ as its own. Is this what really happens?
I mean I think I get what you're saying but why does it take years before it starts getting rejected? Surely as soon as its in the body these cells would be seeking identification from the new cells on the organ?
I like how short these videos are. There are plenty of videos now a days that are just way too long. Like 20 mins average. Usually on subjects like this that can be done in under 5 mins.
1:53 is the other way around, SIRP-alpha is expressed in myeloid lines (monocyte) and CD47 in the donor's cells that conform the organ tissue that was grafted.
What if the immune system and brain was connected in a way like if we understood that the organ coming is not toxic, we could signal to the immune system not to attack. If we could figure out something like that, we could do much more than just preventing organ rejections such as inhibiting allergies
I understand what you are on about.... I thought that if you send the body organs to a mode where they respond but not to their full defense line, would the new musical that is needed be excepted more? A bit like making the white blood cells a bit merry, so when they come round back to their job, they would know their way round the new transplant excepting it as a part of your body?
I forgot to include that by making a brain that repairs its self we need to look down the fruit part of things... bananas are the best fruit to do such a job, they deal with the brain alot more than other fruit... now to make them even stronger they need coating in coconut oil, what makes the banana have backup to help it do its repairing... but if a patient has cancer of any type just let the banana gain a few brown marks on its skin before peeling it ( you can still add the coconut oil if wanted) but with the marks that the banana has gained on the skin it will help cure cancer, and by eating the bruised marks on a banana it's power of recovery is maid even stronger
Fascinating, however, I can't imagine that it would make matching organs to patients easier at all and it may just make the whole process that much more difficult!!
yeah but what side effects would blocking sirp-alpha, it is probably an important protein in the combat of cancer cells, and its not like they would be able to isolate only the organ with the treatment.
Hi I have a question. Living in polluted cities nowadays can you exactly show what would happen if we inhale the smoke coming from automobiles and it's effect in our body too.
This kind of reminds me of how about a century ago blood donations killed people since at the time we didn't know about blood types. I have a feeling that in the (hopefully near) future that this will be resolved and we'll look back at it similarly.
I have an important question: if we get able to make monocytes never interact with the cells of a transplated organ, wouldnt that mean that if the patient gets a virus disease, his organism cant do anything to defend the organ?
I don't know where to ask questions but this is the most recent of your videos (that I could find based on my notifications) so I'll just ask my question here in the comments: Why do the shadows become 'monsters' late at night just as I'm trying to sleep? I've just turned out the light, I'm relaxed and ready for sleep, it's midnight and then I get the feeling I'm being watched, so I look around and can't help but imagine the shadows twisting and rendering themselves into 'monsters' that my paranoia-flooded mind draws in, enlarges and develops. Why does this happen?
if you block the receptor that helps identify foreign bodies then wouldn't that also prevent it from also identifying ACTUAL harmful foreign bodies? or am i missing something?
I wonder if they take the connection between the 2 cells away, it'll result in the immune system not working properly in identifying bacteria, viruses, etc.
I feel like this video doesn't emphasis enough on some fundamental aspects of the paper. After skimming over the actual paper, there's an emphasis on recognition of self vs. non-self in the absence of adaptive immunity. While the focus is indeed on innate immunity, I think it would have been helpful to mention that this whole SIRP-alpha and CD47 interaction functions independently from the more well known MHC complexes.
This sounds awesome, but i have a big question, How much time does it take for this discovery to be made into something every Hospital uses (In case it's not something really expenseive that only top clinics can afford)?
I suspect that if they inhibit the protein from your body's immune system from binding to the transplanted organs cells this would cause that cell to be ineffective at its job in other parts of the body as well.
The more we understand, the more it helps. Knowledge is power and all that. I was under the impression we were moving towards artificially growing organs from stem cells but there's no reason to not pursue both in case one path takes longer than the other.
Yea, blocking it isn't dangerous at all.... like causing issues with your immune system or anything that will cause it to function improperly or anything...
I'm not a doctor but wouldn't that also weaken the immune defense of the new organ if you block the system from "linking up" with new organ. Would make sense. Anyways interesting video.
basicly its a password system for the body. say you have a fort that you are guarding and the only way to who is on your side is by a set of passwords. if someone new shows up and they dont have the password you block them out and send out the hounds to attack. what we need to get by this is find the master password for the body. unlike the basic passwords we have been useing same blood tipe and the same kind of bone marrow and so and so forth. the issue is each body can have its own master password like how each corp has its own backup break in password if the need pops up .
When your body is your biggest enemy...
Ikr i just hate it sometimes
Hmmmm, strange. I can't see any profile picture or name on this comment.
John Cena just stab it for good measure
Damn it, time to do something about.
*Jumps off cliff*
It's actually oxidizing (rusting/burning) your organs whenever you take a breath. If you don't eat, your stomach acid can kill you by dissolving itself.
0:11 _Heartbreaking right?_ Was this the greatest accidental pun of all time? Or planned genius.
60 Second Success You cheeky dog
Oh. We all write together. It was planned. ;)
Lol I was about to post that
Troll Face, wow.. that was halfhearted
The human body is adaptive
Scientists are just liars to keep there operating system ignorant intentionally all done intentionally evil
Why do the subtitles say SHIT IS GETTIN' REAL
demonetized
lol
PreheatedCandy for real?
Yea lmao @1:18
PreheatedCandy OMG 😂😂
I got kidney transplant 11 years ago a week ago. I have to take immunosuppression medicines but now i dont that many infection as before
In short my body is trying to kill me.
If you have an auto-immune disease then yes, that roughly sums it up.
DON'T LOOK AT MY PROFILE PICTURE Actually it's trying to save you.
DON'T LOOK AT MY PROFILE PICTURE in short it always was.
Immune system : Lets reject that weird vital organ!
**Rejected organ**
Immune system : Done!
**The person died**
Immune system : Whoops
Rafie_ArsyadYT XD
At 1:18 the english subs say SHIT IS GETTIN' REAL
OH MY GOD X'D
AwsoGlitch lmao this is why I always have CC on, sometimes they have one person assigned to a certain channel like markiplier they always put jokes and comments in () and are so good at subbing him 😂
It protec but it also attac
theFallenAce xD
theFallenAce dank memes mate.
But Most importantly...
abby x but most impertantly is give heart attac
heart attacacacacacac....you ought to know by now.
we have known this for many many years
i've known ur mother for many many years
i was looking for this comment
This background music made me think a phone is ringing.
Lol
1:16 turn on English subtitle.
hahah ;)
Adil Mughal shits gettin real 🤣🤣🤣
how did that get in? 0__0
What is it
ShowerThoughts SHIT IS GETTIN' REAL.
Patients would need to be careful about diseases then, since it pretty much turns off the body's ability to attack foreign objects aka pathogens.
JoKing I think what they're implying is that they can isolate those certain proteins and block them off. Antibodies for pathogens are made complimentary so blocking off one specific receptor won't be necessarily harmful to the body. Plus I don't think they'd be making a big deal out of this if what they had found out turned out to be worse for your body.
That's why more research is needed, but on it's own this new found bond will help matching organs properly, it's as huge as blood types are to blood transfers imo.
+JoKing - that is actually already the situation. Transplant recipients have to take strong immunosuppressants to help fight their body's attempts to attack the new organ, causing rejection. These drugs also make them very susceptible to other illnesses, that is one of the unfortunate trade-offs. This new information though could lead to more targeted and precise prophylaxis, like something that could prevent the T-cells from getting the message to attack these particular cells, but not messages about other legitimately dangerous bodies. As mentioned in the video, it can also help better match up donors and recipients to reduce the rates of rejection.
That already happens with immunosuppressants, bruh.
As they already said,that's why more research is needed.
Plus if you can actually find a match betwen your system and new organ you shouldn't need it since it wont detect it as a foreigner unknown thing
I hope in the future we can print organs, I had a kidney transplant and it sucks taking medicine because my
Stupid body will reject it!
IAMdeathblade Just think about how there's someone out there that couldn't even get a transplant and died. I would gladly take the medicine if it let me breathe another day.
Ayman008 I know what you mean bro am extremely grateful I take care of myself by working out eating good and soon going to be a police officer! Obviously it's better not to ever have to worry about rejection but in the future everything will change for the better!
Ayman008 I don't have words to express how thankful I am for my lungs + heart, but it's okay to express frustration on all the heavy drugs you're on from here on out. These drugs can have big effects. Like diabetes, for example. I wouldn't be alive without my transplant and I owe everything to my donor and their , but that doesn't mean some days are still rough.
*their family
IAMdeathblade wat happen to ur original kidney?
Our bodies are assholes lmao
If I take this literally u must be a big, black hole.....
It's actually your most valuable homeboy, working behind the scenes, never asking for anything.
theycamefrombehind mine is always asking for food sooo
well everyone's gotta eat
theycamefrombehind I just take care of the food and physical upkeep lol
Anyone else find that ringing SFX in the background music REALLY annoying?
Elan her voice was the annoying part. Frrrrrrrrry; she must have really practiced hard to get that.
My mother just got a new kidney, and the surgeon and doctors is extremely surprised how well her body accepted it. Perhaps it has something to do with that she accidentally matched so well with the snitching cells? I would like to believe so. Also, it would be nice if you also mention the lack of donors all over the world. People are dying while waiting for a new organ..
It's great to see humanity progress. Especially in vital things like this.
Tristan Veerbeek
This is not progress
Every episode she's in is awesome, love her!
So?
Just in case if you dont know, she has her own yt channel called: Vintage Space 👊
I subscribed to it and that is why I said "so?"
Nice video, but bad choice in background music. The "phone ringing" was too loud at times and very distracting.
This break through has made the People's Republic of China very happy and the Falun Gong practitioners very sad. 😞😞😞😞😞😞😞
John Doe why
+Am Mon
Falun Gong practitioners are persecuted by the Chinese government and get their organs harvested by corrupt government officials
I-It's not like I like you or anything B-b-baka oh my god... that's beyond horrific
This is probably fake. The Falun Gong are wierd cultists and the only evidence of this happening comes directly from them.
If your body won't reject the new organ due to adaptive immune system receptor blockage, how is that new organ going to fend off infections or diseases without it?
Yes Amy, you can just simply match the SIRP molecules, because that's how science works
yeah but once they figure it out the real question is how much will they charge for it..
Jason Thiner well i was charged 2000$ for 2 stitches in my pinky so..... 90 trillion dollars or so
"SHIT IS GETTING' REAL" CC on 1:17 lol
FRANKy what
FRANKy p
1:18 English Captions "SHIT IS GETTIN' REAL"
So has this always been know because I always knew it was because of the immune system or ??
She wont reject my organ...
FooledbyRandomness2 ( ͡° ͜ʖ ͡°)
LMAO LOLOLOLOLOL HHAHAHAHAHHAH
JK
Vaginas can't be transplanted, you perverted lesbian!
Well, it's hard to reject something that is too small to feel being inside.
*RO-RO-ROASTED!*
Hope they don't reject my testicles
This has to be the coolest and most educational episode in a while. I only wish they had more for this episode!
Heh, my body only attacks new orgasms and not new organs.
Jan Sanono Heyooooooooooooo
whoa.
really?
I thought if it was going to reject it did it early. I guess you learn something new everyday
So for short imagine a new roommate lives in your dorm and it's a 50/50 if teir good or not and if their bad you murder them
I had a kidney transplant in May 2013. so far I'm doing good taking my medicine like I'm suppose to
Snitches get stitches
So it's like keeping two rowdy kids away from each other so one doesn't get suspended
I liked the video except that dang obnoxious ringing in the background audio. Nothing helps me pay attention to a video more than the repeated ringing of a seemingly far away telephone.
The major problem is that patients stop taking their immunosuppressive medication as required. Even though it is fully paid for by public social insurances in most countries (as is the surgery itself).
Still need more organ donors. Maybe make it universal that person have to declare that they DON'T want be organ donors, assumption being that everyone is willing donor (presumed consent, opt-out). Like the opposite to present situation. Finland and Austria has had this system for many years and i bet there are many more. Instead of having "donor card" in wallet, one would have "Not a donor"-card. Would greatly help with patients waiting organs, sometimes years. Would not solve the issue but alleviate it.
Alaric Balthi So when you're born, make sure you uncheck the box that says "organ donor".
+Ayman008 Hah, that would fun to see :D
Any one person, at any time, can and could make it known with simple credit card sized card that says that person does not want to be organ donor. Wording does not matter, as long as it's clear to read during emergency. Even verbal opting out is possible, letting relatives know what person wants if worst happens so they can let hospital staff know how to proceed. It really is simple, it's just a matter of will. And again, anyone can and could say no. Organ doning should never be mandatory. Person should have the last say on what happens to his body. Problem now days is that there are so many people who have not thought of this and when the tragedy happens, no one can say what to do. And because organ doning is a process where there is little time to waste, many people who could have helped, have no chance to help. In my country there was earlier a opt-in system in place so i made an organ donor card when i turned 18. I still carry it in my wallet despite the fact that we changed into opt-out system. It's not needed (perhaps) but it clarifies and removes the hesitation where medical personel has try to find out if person had objection to organ doning. But that's me and this is one suggestion.
+mimi // True, but that sounds like too far into the future. I like Alaric Balthi's idea. I don't know the situation with waiting for organs, but I can easily imagine that a lot of people are neutral to the whole thing and don't particularly care about keeping/losing their organs. It's just that signing up never seems to cross their mind, which this kind of system would address.
Alaric Balthi
That takes away freedom, America is about freedom dumbass
Wolfy The Wolf America isn't the only country with freedom dumbass. Get your patriot ass some brain cells.
Lol, it's highschool biology immunity module all over again
he protec, he attac but he also rejec
Carrot made my day 😂
Doesn't perfusion decellularization solve organ rejection? remove the cells from the donor organ such that a scaffold that is fully intact remains. Then recellularise with the recipients cells before transplant.
still amazed we havent made synthetic organs whether grown from the patient's own cells or bio-mechanical in nature
That's still in developement, and with neural links we'll be faster at research, like cancer cures by tomorrow fast. Can't wait until it's made (by 1 or 2 years.)
+pyromancer I doubt we'll see any synthetic organs in the near future. I don't now how advanced the industry is, but organs are complex machines themselves. I think we'd be hard-pressed to synthetically recreate something so elegantly designed.
pyroromancer you say this like it's a simple task
Jacob Henderson
That's because he probably doesn't really understand what he's talking about.
So. With the head transplant coming up. What part would be rejected? Would the head reject the body... or would the body reject the head?
turn on captions at 1:14
ITS GETTING REAL 😂
This is very informative. I never knew our bodies rejected organs that are transplanted. Thank you.
Will someone answer that DAMN phone!!! I couldn't even watch the video!!
I thought I was about to learn a new pathophysiological mechanism, but I new this already. Only thing this video taught me was that they were able to narrow it down to the specific Sir alpha antigen
Everybody, please speak up and don't rattle your voice at the end of sentences, called "vocal fry." I am only a little bit hard of hearing , but it makes it harder to understand and isn't good for your vocal cords, either. For example, on the word "cell" in "...another type of immune cell" @ 1:57. Thank you.
But if there are more things that need to match for a transplant then you'll have to wait longer for a matching transplant, right?
put on CC and go to 1:16
Nodge shit is getting real, i was gonna comment first
As a heart transplant patient that has gone through rejection there is a reason they give you anti rejection meds. They lower your bodies t cell count so that your organ doesnt get rejected, also another reason the organs only last up to 15 years is that they were dead at one point and started to decompose
basically we know this thing for many many many many years from now
not a hater
As far as I know, transplant recipients only need to take anti-rejection medication for a number of years and then they're fine without them. I used to think that the recipient's body eventually accepts the transplanted organ as its own. Is this what really happens?
Lol, didn't expect to see Amy here.
I mean I think I get what you're saying but why does it take years before it starts getting rejected? Surely as soon as its in the body these cells would be seeking identification from the new cells on the organ?
your barber needs his organs to be rejected
I like how short these videos are. There are plenty of videos now a days that are just way too long. Like 20 mins average. Usually on subjects like this that can be done in under 5 mins.
Damn....the immune system dumb smh
The immune system is not sentient, therefore it cannot be dumb.
pranked
or.....
hmhm.
Aditya Sam House anyone?
Its the reason your alive lol
1:53 is the other way around, SIRP-alpha is expressed in myeloid lines (monocyte) and CD47 in the donor's cells that conform the organ tissue that was grafted.
Its something funny written here .Now you will like this.
Blocking it could cause rampant cancer growth witch is usually in line with transplant patients
🅱️ o n e l e s s 🅱️ i z z a
🅱oneless 🅱ones
Gungame 2016 🅱o🅱 the 🅱uilder
0:11 - "heart breaking, right?" A pun joke! You never cease to amaze, seeker.
First
Woah
Thanks for the frrrrrrry voice: it really helps in understanding your presentation.
What if the immune system and brain was connected in a way like if we understood that the organ coming is not toxic, we could signal to the immune system not to attack. If we could figure out something like that, we could do much more than just preventing organ rejections such as inhibiting allergies
I have a question. Couldn't this new found information be used in Lupus patients too?
sounds interesting, but just a simple question: what happens if a virus or bacteria that infects the modified organ and gains this ability as well?
I understand what you are on about.... I thought that if you send the body organs to a mode where they respond but not to their full defense line, would the new musical that is needed be excepted more? A bit like making the white blood cells a bit merry, so when they come round back to their job, they would know their way round the new transplant excepting it as a part of your body?
I forgot to include that by making a brain that repairs its self we need to look down the fruit part of things... bananas are the best fruit to do such a job, they deal with the brain alot more than other fruit... now to make them even stronger they need coating in coconut oil, what makes the banana have backup to help it do its repairing... but if a patient has cancer of any type just let the banana gain a few brown marks on its skin before peeling it ( you can still add the coconut oil if wanted) but with the marks that the banana has gained on the skin it will help cure cancer, and by eating the bruised marks on a banana it's power of recovery is maid even stronger
What do you call a cyclist, who doesn't wear a helmet? An organ donor.
I have had two failed transplant an have to get another done this coming week it's a nightmare
wouldn't it be more beneficial to somehow change the receptor on the donor organ rather than block the signal altogether?
Fascinating, however, I can't
imagine that it would make
matching organs to patients
easier at all and it may just
make the whole process that
much more difficult!!
yeah but what side effects would blocking sirp-alpha, it is probably an important protein in the combat of cancer cells, and its not like they would be able to isolate only the organ with the treatment.
But wouldn't blocking the SIRP-α docking mechanism cause complications detecting actual threats to the body?
Hi I have a question. Living in polluted cities nowadays can you exactly show what would happen if we inhale the smoke coming from automobiles and it's effect in our body too.
Wait, but if you bind this SIRP-Alpha from attacking, won't it also stop attacking actual threats like bacteria and viruses?
If they stop those interactions won't the body be vulnerable to any other disease while that is going on?
This kind of reminds me of how about a century ago blood donations killed people since at the time we didn't know about blood types. I have a feeling that in the (hopefully near) future that this will be resolved and we'll look back at it similarly.
0:22
Doctor be like "this is what I have to do, right?"
"...What the hell am I doing with my life"
You are absolutely awesome Amy! I LOVE you
Wouldn't cutting off the "alarm" for T cells to attack mean a higher risk of normal infection?
I have an important question: if we get able to make monocytes never interact with the cells of a transplated organ, wouldnt that mean that if the patient gets a virus disease, his organism cant do anything to defend the organ?
sounds like dangerous side effects of that not attaching in other future cases
This is huge. Hopefully it will actually be able to work
I don't know where to ask questions but this is the most recent of your videos (that I could find based on my notifications) so I'll just ask my question here in the comments: Why do the shadows become 'monsters' late at night just as I'm trying to sleep? I've just turned out the light, I'm relaxed and ready for sleep, it's midnight and then I get the feeling I'm being watched, so I look around and can't help but imagine the shadows twisting and rendering themselves into 'monsters' that my paranoia-flooded mind draws in, enlarges and develops. Why does this happen?
if you block the receptor that helps identify foreign bodies then wouldn't that also prevent it from also identifying ACTUAL harmful foreign bodies? or am i missing something?
I wonder if they take the connection between the 2 cells away, it'll result in the immune system not working properly in identifying bacteria, viruses, etc.
I'm giving my mother a kidney and I'm terrified her body will reject it. What happens after rejection? Can you live with out a working kidney?
I feel like this video doesn't emphasis enough on some fundamental aspects of the paper.
After skimming over the actual paper, there's an emphasis on recognition of self vs. non-self in the absence of adaptive immunity. While the focus is indeed on innate immunity, I think it would have been helpful to mention that this whole SIRP-alpha and CD47 interaction functions independently from the more well known MHC complexes.
This sounds awesome, but i have a big question, How much time does it take for this discovery to be made into something every Hospital uses (In case it's not something really expenseive that only top clinics can afford)?
You guys always make good videos, subscribed ages ago.
I suspect that if they inhibit the protein from your body's immune system from binding to the transplanted organs cells this would cause that cell to be ineffective at its job in other parts of the body as well.
This is somewhat similar to people who are Rh negative and cannot receive blood from Rh positives
Damn ! If we can reach near 100% that would be awesome news !!
The more we understand, the more it helps. Knowledge is power and all that. I was under the impression we were moving towards artificially growing organs from stem cells but there's no reason to not pursue both in case one path takes longer than the other.
uhh.... if they cut that reaction, wouldnt that screw up theyre immune system because changes in the transplanted organ would not be accurately read?
Not just a breakthrough for Transplant patient's this could help with a host of Autoimmune disorders, More Research is Needed.
Yea, blocking it isn't dangerous at all.... like causing issues with your immune system or anything that will cause it to function improperly or anything...
I'm not a doctor but wouldn't that also weaken the immune defense of the new organ if you block the system from "linking up" with new organ. Would make sense. Anyways interesting video.
basicly its a password system for the body. say you have a fort that you are guarding and the only way to who is on your side is by a set of passwords. if someone new shows up and they dont have the password you block them out and send out the hounds to attack. what we need to get by this is find the master password for the body. unlike the basic passwords we have been useing same blood tipe and the same kind of bone marrow and so and so forth. the issue is each body can have its own master password like how each corp has its own backup break in password if the need pops up .