Evo-Devo (Despacito Biology Parody) | A Capella Science
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- Опубліковано 22 вер 2017
- This is how we go from single cells to people.
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EVO-DEVO
Huxley
B. Mac.
Oh Carroll, Carroll
Gould, Stephen Jay yeah
D-D-D-D-Davidson and Peter
See
One cell divide and decide on a thousand fates
Did you ever figure how they know?
B. Mac.
We
Are built of modules combined in a planned out way
Each new piece must be told where to go
Oh
Now there's a science helping us to understand
How our cells encode this architectural plan
Signalling each other with genetic tools oh
Oh yeah
Wow
Phenotype the interface for mouse and man
Genotype the files and the subprograms
What then are the switches, circuit boards and boot code?
Evo-Devo
Looking at the logic in the ways that we grow
Every gene directed by a signal key code
Proteins that can activate, enhance or veto
Evo-Devo
Signals are controlled by other genes that signal
Calculating in a network labyrinthal
Where the heart and liver and the hands and feet go
Signal mapping tells each region what it ought to be yo
With circuits so deeply built upon
They're older than the Paleo
The Paleozoic Era baby
In a crucial pathway changes tend to get torpedoed
Where they go calamity goes
As this cyclopic sheep knows..
See down they cascade like a domino
Like you and I drosophila
The path that makes us optical
Was laid a long long time ago
Back before we blew up the cambrian like a bomb bomb
Now my eye protein can make you see out of your bom bom
And Hedgehog and its relatives like Indian and Sonic
Set up set up in a gradient on segments embryonic
Split forebrains and asymmetric parts depend upon it
Flipping on genetic switches and logic
From devo to evo
Adult and embryo
Mostly don't evolve in the genes of the genome
Safer the mutation aimed at regulation
Keep the building blocks and swap their activation
From devo to evo
Parts have alter egos
Homologs evolved from repeats in the schema
Switch a couple bases in the proper places
You'll be watching flies grow legs out of their faces oh yeah
Evo-Devo
Stick around for Modern Synthesis the sequel
Only by combining can a new theory grow
Evolution and development amigos
Evo-Devo
Signals trigger patterns of complexity so
Switching up the switches of a signalling node
Gives a modular and simple way to evolve
Look at how our spinal segments generate a neat row
Built on a molecular clock
One cycle, one vertebra
One vertebra one vertebra baby
Speeding up its rate is snakes' developmental cheat code
That and where a lizard's feet grow
They turn off distal aminos
Evo-Devo
This is how we go from single cells to people
Every generation and in life primeval
Life in variations endless and beautiful
Badaboom
From devo to evo
Larva to mosquito
Patterns are resolved as the signals proceed yo
Map out a gene with a glow tag
Kill it with a morpholino
Short oligo morpholino baby
From devo to evo
Voyage of the Beagle
Body plans evolve when proteins steer the genome
In this manner life's beauty grows
Aesthetica in vivo
Evo-Devo - Наука та технологія
At first, I was thinking, "There's no way he can make that song work." I was, clearly, wrong.
Trygve Plaustrum he's a fricking genius
Yep. He deserves 1b views
Only three reply's? Wtf
I already love the song so anything that sounds like it I can enjoy, but this takes it to another league
Why did i read this in Captain Holt‘s Voice 😂
This is literally an entire semester of a 400-level Evolutionary Developmental Biology course, summed up in a 5 minute song. Fucking legendary.
I, now, shall torture myself by researching every meaning of every phrase of this song. In the next 24 hours. Oh man.
@@j.s.ospina9861 You'll learn so much researching these subjects that are presented in this video :)
@@j.s.ospina9861 already on that 😂😂😉
@@j.s.ospina9861 That's a good thing to do but you should never go above what your learning as it will be useless for you at the moment and you will thought about it or deselect the stuff that you should be learning (stuff that is less complex but necessary for your grades) But depends what year your in and what level in science most likely Lv3 BTEC+.
Yeahhh ahahah
Biology aside, someone has to mention how absolutely INSANE this acapella is musically. He is not using any external instruments apart from his damn mouth. Absolutely incredible.
I don't think a better science song will ever be produced. This is the peak.
@@taka4059 Says someone who hasn’t seen the _rest_ of his channel. This isn’t even his best work.
I didn't even notice until you pointed it out
are you sure that ALL sounds are produced by mouth? because some background sounds really don't sound like that
@@Ultrasemen they are, just modified by program but all came from his mouth
I STILL get shivvers from how good this is. 3 years later.
I'm still so impressed that the words rhyme, are similar or even the same as the words from the original song yet still put into a parody that makes sense. it's truly a masterpiece
It is actually really good isn't it , this shit need to go down in history
Same, I can't control it. The song is so good. And I love biology.
Same
Try 6 years
Finally! Someone translated despacito to English. I'm pretty sure the translation is very accurate.
Miguel Martínez lol
Oh hell no😂
Ahh yes, I sing this in public and everyone looks at them in shook. I think they are shocked by my knowledge about biology, BIG BRAAAIINNN!
@@nicolaswolf3873 yeah, this Is big brain time.
Yeah the song is really deep and educational but the english speaker has been losing all it XD
Friends : What type of music do you like to hear ?
Me : It's complicated
@Aadishree Chaurasiya ohh i am 22year guy and i could hardly understand props to u.
LITERALLY
I find it simple to answer, I usually just say mostly educational parodies and Weird Al Yankovich, which isn't always educational though :)
See once cell divide and divid-
well guess what... i sent this and all his other songs to almost everyone I know :)) but sadly a lot of them don't care which makes me sad :(
This is a masterpiece and must be protected for future generations
250+ likes, and no ones noticing in the comments that a DOCTOR said that. I'm happy to agree with you
Agreed. We must put this on the next Golden Disc.
Someone call Capitol Records
Future generations won't even understand what he's talking about 😂
This is so incredible. The fact that he can put all these talents into one. The singing, the acappella, the scientific knowledge, the brilliantly clever song writing. Literally amazing
u forgot video production
Yeah, the animation is way too good!
When I get demotivated studying biology, I comeback to this and get hyped to study bio again.
Same ^^
THIS^^
Same :)
☀️☀️☀️🔥♥️💙💜🧡💛🖤💚🎶❤️
Just found this and I am totally come back to this when i need motibation
Hey Tim, are you aware that a guy called Luis Fonsi made a parody of this song called "Despacito"?
Yup, that too in Spanish
Yeah, weird right?
surprised there are not any wooshes! maybe people ae FINNALY get smarter
aRe YoU sTuPid oR sOmeThiNg? thIs iS tHe paRoDy oF dEsPaciTo? u R sUcH a fOoL. lOl XD
No Despacito 2 came first. Then this came and later that Despacito.
I watched this video four years ago, and since I was interested I bought and read one of the books he talks about in the end (Endless forms most beautiful, I think, I read it in Italian so the title was different but still).
Anyhow that is how I got into evo-devo. Four years later and I am currently enrolled in a master's degree in Evolutionary Biology after completing my Bachelor's. Finally about to get those detailed classes :)
Keep doing this kind of work, it can really capture the attention of young scientists!
That's amazing. Good luck with your studies.
Good luck. I am also a biology master but done. immunology though and his evodevo song deeply impressed me. Evo was alway one of my guilty other pleasures in bio. ❤😊
Is it just me, or does anyone else get all teary-eyed towards the end when he sings "in this manner life's beauty grows..." Man, I love evolutionary biology
Right there with you, man
"Aesthetica in Vivo" is just the title of a textbook but now makes me weepy purely by association with that line, yes
for me it's "Life in variations endless and beautiful", but the sentiment is the same
@@hannajung7512for some reasons when he says “voyage of the beagle” that just like hits so hard for me, and the “BADABOOM!”
This deserves as many views as the actual song.
And more.
Many, many, many more.
Sebastian Elytron exactly this song turns a good beat with fairly bad lyrics and turned it into an amazing song teaching people the importance and power of evo devo
This thing is really ridiculously fantastic and I liked it so so much
You spelled "more" wrong.
When your Mother wants u to be a Musician but ur Father want u to be a scientist...
RightPurpose And you end up being a UA-camr.
When ur asian mother makes you pick up an instrument and become doctor
@@crowridley8245 This doesn't use instruments
@@pointed.sphere anything is an instrument to complete anything XD
@@pointed.sphere the voice is an instrument, check mate
When u find out u are 1% Latina but
*99% Laboratory technician*
"Back before we blew up the Cambrian like a bomb, bomb"
Shout-out to the Precambrian explosion!
This is genius. As a molecular biology grad (whose favourite class was evo devo, cause I'm a nerd like that)...this hit the exact right chords hahaha
More like the exact right NOTOchords! *badum tsh*
Not sure evo-devo is any nerdier than the other subjects lol
Oof i ruined the 556 likes by adding one. (5.56 mm anyone?)
I like this song🤘🤘🤘
@@clockworkoconnor2748 Uh hmm. Touche'.
The fact that I can listen to this over countless times and each time find a deeper reference, meaning or beauty to it is reminiscent of the field of biology itself.
Your understanding of the lyrics is evolving and developing over time.
"What genre of music do you like?"
*"Science."*
Science, Acapella Science.
I really love the line at 2:24 where it goes „switch a couple bases in the proper places you‘ll be watching flies grow feet out of their faces“ 😹
I sometimes feel sorry for the flies that we did these experiments on. Replacing their antennas with feet, making them grow eyeballs on their posterior...
@@bemusedalligator If you were born with legs on your face. and everybody you ever saw also had legs on their face... would you feel sorry for yourself?
@@thomasneal9291maybe. I question a lot of things about the hateful corpus I currently inhabit, but it looks pretty much like everybody else's ¯\_(ツ)_/¯
So you made a well-constructed parody song about biology, with matching lyrics and metrics that also serves as an accurate educational summary of genetics.That requires... a strange combination of skills.
.
A True Renaissance Man, a polymath!
*an awesome set of skills, you mean.
"A very particular set of skills..."
An incredible rare recombination of genetics and environmental circumstances? :P
Anyone prefer this to the original Despacito? :)
sqrt(-1)
dont think anyone prefs the og one over this, this is so amazing, and sciency! :D
Yeah, cause I can understand this.....lol
Considering that I usually listen to Despacito for the melody, this is definitely more fun xD
Oh nah how could you prefer the original over this one? This probably took way more effort and is way more better
I am not a biology major, so I ended up googling each term in order to understand it. This song is fascinating.
This is taught in high-school 3 dif times
@@katza831a basic overview is taught. Evo devo is a whole university level course
This song is Fuckin Legendary! It's been 4 years and I still can't get it to stop playing in my mind. At totally random times, I sometimes shout 'Signal signal!' or hum random parts of the song while reading. This song is like the Genetic code itself, tightly packed with the entire summary of Evolutionary and developmental biology in a few minutes. I was starting out with Embryology when this song came out and this made me understand the genetic regulation part so well. Still waiting for some more amazing songs like this one. This is still my favorite though. It was my ringtone for a year.
The only problem I had with Despacito was it's lyrics, thanks for fixing it.
I think it's the only problem everyone has with the song
The lyrics are GARBAGE but it's catchy af
Great
Original version- Sounds good but means shit.
Biological version- Sounds good and is a meaningful song.
Since when is it meaningless to make people feel good? :)
Watch the english version and you will know.
Its by itsdvd
Actually Despacito is a simple Spanish romantic song that doesn't mean much. It's the video that is shit.
Well it's not as much romantic as it is sensual. Which is not a bad thing, as far as those go, it is a good one. People just hate it because it was overplayed by far.
"Aesthetica in vivo" gives me chills every single time. Amazing work.
1:56 i still can't get over the fact that Sonic Hedgehog is the actual name of a real protein and the gene(s) that make(s) it
Normal person* cant understand despacito*
Science geek*forcefully puts science into it and everyone loves it*
(Including me)
*_Hello fellow weeb_*
@@slolilols hello there fella
Finally someone who matches my intallet....
@@kamadotanjirou9093 Indian otakus are hard to find anyways lol
@@slolilols yeah ppl here r weird they r living without waifus
I did not knew it was physically possible
Well most of them call anime cartoon, so they r not living anyways
@@kamadotanjirou9093 *_exactly, they don't understand the greatness_*
It's nice in some way because the original Despacito is about how he wants to do that process of making a new human with her, and the emotions involved, while this is about the actual biological process that occurs when this happens :P
i know right? "wait!! come back! i'll get you hooked on my kisses and make it so you never want to leave!! "
Hahahahaha love it!!! Good job, keep posting videos like this.
How far have these kinds of videos come. In high school they had some videos like these for classes but they made me cringe out of my skin to the point I couldn't even watch them. Meanwhile, I'm in my mid-20's and watching this on repeat because the animations and lyrics are addictive.
I come back and watch The Molecular Shape of You and this video back to back every year or so. They flow together so well. Two of my absolute favorite videos on UA-cam of all time.
I need "Switch a couple bases in the proper places, you'll be watching flies grow legs out of their faces" on a T-shirt. ASAP
Second this
I need an "Evolution and Development Amigos" t-shirt which has the diagram at 2:40 in it!
....I third this?
I fourth this
I'd buy it.
when u realise the beaats were coming out of his mouth..
Holy fucking shit, you're right O__O
Yeah, that's the meaning of acapella :v
Oh lord... Yes. I noticed only after reading your comments. True Artist.!!!
That's the whole purpose of the channel, actually... This shouldn't exist in a normal world, but I'm glad it does.
This was my first exposure to Acapella Science (I was on a mission to find as many covers of Despacito as I could). What an absolutely brilliant piece of work. I spent days after going down internet rabbit holes trying to learn as much about evolutionary development as I could.
These videos make me cry because of the beauty of the universe
This song was playing when we lost our cat, Prim. It sounds trite, but I loved that cat. Let's defeat Entropy. For Prim.
I study biology and I play this song 8 times a day in my exam's period ("take exams" too). Actually I was listening to it today before my develop biology exam to motivate myself and guess what??? Drosophila's develop was question 3😂
This should get more views than despacito.😂
physicist j I hear you bro!
Yes !
but it wont.. this says enough about homo sapiens..
I understand this better than that too
physicist j I doubt it. 3.8B is a bit of a stretch to say the least
Still listening, added 100 more plays. My favorite line starts at 3:13. “Molecules-to-man evolution” (and similar alliterations) is a favorite phrase used by Creationists to describe the apparent foolishness of thinking that humans could've evolved from single-celled organisms. I get chills every time I listen to you sing that part because of the joyful freedom of escaping those shackles. I have so much catching up to do, but people like you inspire me to seek out more knowledge everyday.
I love your comments. I see the beauty and emotions you describe and share them with you. All my life I have never found deeper meaning, greater truth or more joy than in scientific discovery.
If you haven't read Endless Forms Most Beautiful yet... it's one of my favourite books of all time.
@@davidpape1160 I have read half of it so far, but it's a little over my head. I'm trying. 😅
I grew up believing in a literal creationist mindset, yet God showed me the beauty in His creation and the structure of it. Science, as far as I have seen, is merely showcasing how God made everything. The structure, the design. It's all clearly divinely inspired and ordered.
There's a book out there called "I don't have enough faith to be an atheist"
I watch this at least once every 6 months and am blown away every time.
You really should make a video where you explain all the science behind every line. Even if it was an hour long I know that I and many other people would watch the whole thing. If you don't then someone needs to because it feels like a waste for all this amazing science to go over the heads of so many people
agreed
Adam Wilkinson I took classes in this field, believe me 1 hour would not cover it. Maybe 8 hours.
The vast amount of science that these videos cover is like entire semesters worth of info. For example, I took a class called biological development and it didn't cover all the details in this song (most but not all) and it was an advanced level elective mainly for graduate/senior students.... Then, consider that to get to that class, I took many other prereqs to build up my baseline knowledge.
Adam Wilkinson I half agree but also folks can just google for the science behind every line. eg the TED talk on the cyclops sheep
Adam Wilkinson isn't that what a college application is for?
Some fool: Evolution is a myth!
Me, an intellectual: This is so sad. Alexa, play Evo-devo.
At 30 seconds: "We Are built of modules combined in a planned out way. Each new piece must be told where to go."
That fool you mention is going to claim that's evidence for Intelligent Design.
Mike Public while not listening to the rst of the song...
Evolution is a joke.
Change my mind.
Evolutionary Programming is a class of Artificial Intelligence algorithms based on evolutionary principles, so in a way, we were intelligently designed.
Alejandro Ibarra evolution is a great theory
Changed my mind
I maintain, and will forever, that this video is perfect. Your performance is flawless, the song is incredible, and it's literally a college level bio lesson in lyric form. Incredible! Please keep doing what you've been doing
This Made Me Fall In Love With Biology And Inspired Me To Become A Doctor
This was published 3 yrs ago.
You are a doctor now
Plz tell me you did everything in 3 yrs
Or did you see this in the middle of your education?
@@muhammadbinyaqub16 LOL I Am A Pre Medical Student I Meant This Video Inspired Me To Take Biology As A Further Subject Of Study
Hi pain
@@pratik01. :)
That was awesome! Thanks for the shoutout to this fascinating field of evolutionary biology!
Strange Stuff and Funky Things Interesting how your comment has 1000 likes yet am first comment.
Duude! Ikr
Just a thought, I mean this is just going way out there, probably not relevant, but the dude has 12k followers, maybe a few of his followers enjoyed his comment enough to like it? (Also, likes on youtube are like fools gold, they're shiny but not really worth anything)
Strange Stuff and Funky Things hahahaha
Evolution is a stupid theory with no evidence
This genuinely sounds better than the original, even disregarding the cool science stuff.
41 rhymes on Despacito
I was studying evolution and suddenly I remember this masterpiece exists.
I listened to this a few years ago for the first time, being an innocent high schooler. After studying genetic biology from 1 year , this is a masterpiece. This song is filled with creativity and knowledge and it is entertaining. I am definitely showing this to my teachers.
The first Despacito version that you can actually listen to!
"I wear Speedos" is not bad for the purpose of parody.
It's pretty terrible, just looking at the quality of writing - the creator rhymed "speedo" with "speedo" way too many times.
Check out Malinda Kathleen Reese
Ivysaurman your'e focusing on one word? Lol
TheVarxo
The best part is the word "speedo" isn't even in the video...
I'm a biology student........and OMFG each and every word is so damn true👌👌👌👌👌👌better than spanish despacito😂😂😂🤣🤣🤣
I bet it's gotta feel so rewarding to understand everything from the first listen, can't even imagine.
Siddharth Jain I honestly only knew a gene and dna could create living things, but now I know how they manage to pull off organizing many cells into massive creatures in such order.
So relatable
I was a professional degree qualified British biologist (now in an engineering career). It's a false message. Data and code never, ever appear from chance events. Don't believe this. The message SHOULD Be: Design does not come from chance events, which is what evolution proposes.
Surfer7901 you’re absolutely right
An instrumental version of "Despacito" is playing in the Starbucks and all I can think about are the lyrics to this song.
Seeing biological ideas combine so flawlessly in this video is so fascinating, I don't know how to explain the feeling this video gave but the complexity and the connections are displayed in such a magnificent way, far better than my textbook, that I feel reinvigorated to learn biology once again with ferver
Ya ,u are right 💫
WHY IS THIS SO DAMN GOOD?!
I don’t know
Mac Dege because science
because science!!!!!!
Seriously, this video made me laugh while also making me almost cry in happiness. I feel like this is the purpose of the internet. Watching this video made me order a book on Evo-Devo.
Mac Dege
I D O N T K N O W B U T I T IS AAAAAAAAAAAAAAAAAAAAAA-
If radios play this guy’s songs, kids these days would be a lot smarter.
Woot Tada your dp though😂😂
i really like it
Holy... every line gave me severe chills. This was the coolest song I ever listened to o-o
Haha, same!
This video introduced me to Evolutionary Developmental Biology, and the field has really changed how I see life and really help set my life forward in a direction I'm happy with. So, thank you A Capella Science.
Damn, boy. As every song comes out I think - "There's no way he can ever top THAT one" . . . and then you do. Utterly amazing.
People already look at me weirdly when I sing "ligo feels the space is rippling through...", I'd love to see their faces the next time I hear despacito and I start singing evo-devo hahah
My 2-year-old (Tim's niece) sings Aladdin songs about "shining, shimmering planets." I am ok with this.
Mary-Jane Blais hahaha that's cute :) make way for Pegasi!
+Mary-Jane Blais She's gonna be weird.. but good weird 😃
acapellascience hey Tim. I spent 2 years at the university of Cambridge doing research on solar fuels (Reisner lab). Let me know if you ever want to do a song about it! :) I can also sing :P
I feel you... I sing 'when orbitals take the shape they do...' to myself so often I've forgotten the words to the original song.
I come back to this song every once in a while to reset my love for genetics
My professor actually showed us this video in his Evo-Devo lecture
I love how the animations at the end of Molecular shape of you and the beginning of this song line up seamlessly
man im not a bio person but this shit is lit
6 years later, still a banger.
How many times have you watched this?
Me: *Yes*
Only legends noticed that this started from where molecular shape of you ended ;D
nice observation
After I read your comment I've noticed. I think I'm a legend now. Thank You!
Woo 95 likes thank you so much guys!
not to brag but I spotted it straight away lol
Zenanov Hi, i made an amazing science rap battle. you wud love to hear. Plz check it on my channel. Do give your valuable feedback.
As a biologist I'm drinking a Stella, working on some bioinformatics stuff, with this in the background. It's midnight. Oh boy...
I'm a post-doctoral researcher working in bioinformatics and systems biology. I love this! I can't stop listening to it!! It's like everything I'm passionate about turned into music! 😍
You're so cool ! Like some kickass marvel character !
Brett Chapman this one and the Ed Sheeran parody by him are so good!!
Brett Chapman haha thanks! :)
Thanks for your work, y'all~
F**KING AMAZING
Your ability to turn scientific understanding into something anyone can enjoy is a gift to the world
2:07 epic...
WAY BETTER than Despacito, I don't care what my friends say 👍
better visuals....
Laix Takes because it's science
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acapellascience As always, way better than other parody out there. But it really sucks to see such low amount of subscribers in your channel!
It's because not everyone's a huge nerd about science, I guess.
acapellascience Oh excellent ! 😍
and luis fonsi..
Dude, your my favourite channel, you take the songs I hate (despacito, shape of you, Mr sandman, pumped up kicks) and make them awesome!
I understand none of this and somehow still enjoy it more than the original
The way he can sing these fat words so fast is mind-blowing. Respect
Your covers of these popular songs have become my all time favorite songs! They never get boring like normal songs do. I've been singing along with you using the description once everyday and I feel happy everytime. Singing science based lyrics also makes me feel better about studies that they don't have to be hard and tough always. Thank you so much for these masterpieces! When I'll get into college, I'll certainly ask them to invite you on the first event/fest right away!
BIOLOGY STUDENTS?
Here
CREEPY CRIES Here
Do biomedical sciences count?
@@okada1103 Yes! Same here
hi, here as well
I have actually never heard the original version of this song (since I avoid pop music as a rule and have not listened to it on the radio as a matter of principle for most of three years) and, judging from the translation I looked up, I'm glad I haven't. That said, this is brilliant! My passion is physics, but I often feel that I don't spend enough time thinking about the other sciences. This excursion into the world of biology is refreshing and fascinating. Thank you so much Tim Blais for the wonderful work you do.
(On a different note, the spelling of "sequel" at 2:33 is bugging me more than it probably should.)
+Eliza Dagnabbit there's always the one typo 😐 But thanks! Happy to bring bio to a fellow physicist--and bangin' pop tunes to a new audience!
If you want more conceptually digestible biology, I highly recommend Inès Dawson's Draw Curiosity channel.
I can't fathom how you've managed to avoid pop music in public spaces.
I wonder on what basis or principles you decided to avoid pop music,I mean not having interest is understandable but just outright avoiding it purposefully seems like something a hipster would do to make him/herself feel special.
shouldnt have seen that typo damn it..ignorance is bliss
well if youre against the values of those songs which sometimes are argueable it seems reasonable altough it doesnt do much
Goated video. My prof has this as an intro video to her cell biology course. Was skeptical going in, but will probably watch this a couple hundred times.
This somehow makes me really proud of humanity
Finally, a version of Despacito that enhances your brain, rather than melts it.
Planetesimal Brilliant 😂
Yes
Thinking the exact same thjg
Hum, I prefer to think that it stimulates a different area
Actually, learning another language improves cognitive skills and overall brain function. Looks like you should try it sometime.
As a biologists, I love this song
What part of biology do you study?
wanderingazn molecular genetic
Sweet! Biologists represent!
😃
Even myself love this song even I am not a biologist.
I've listened to this probably 30 times recently. As a recently recovered Young Earth Creationist who wasted the best 15 years of his life absorbed in that crap, finding actual science and seeing it so eloquently put together gives me immense joy. Thank you for all you do.
Bravo to you for opening your mind! That's not easy to do and takes great courage so I applaud you for doing it.
@@wallacememberships Thank you! It's been so exciting seeing the world through new eyes. I'm like a child all over again. Life is so much freer leaving religion.
@@imagomonkei It’s not necessarily religion that’s the problem. The problem lies in excessive literalism and rejection of facts that run counter to deeply held beliefs. It’s entirely possible, and even healthy, to embrace both science and religion; case in point, Gregor Mendel and Georges Lemaître.
But I’m not here to proselytize. I just wanted to throw in my two cents as a churchgoing astrophysicist. Glad you were able to recover and find this wonderful community. Cheers, mate!
I find it hilarious that this long after we realized we could use human eye proteins to make a fly grow a FLY eyeball in the wrong place because of a shared gene switch from the paleozoic, there are still creationists.
This field is exactly the response I give to creationists who insist that we mathematically couldn't program our DNA in several billion years from a coding perspective. If you stuck with machine code, you couldn't mathematically program any version of Microsoft Office or any code made in the past 20 years with the combined knowledge of every human who's ever lived all working at once. However, use machine code to create Assembly to create C and C++ to create Java and other higher level languages to create program-specific languages and the job becomes exponentially easier. Same with evolution, as long as genes can turn other genes on and off like pointers, the impossibly complex human genome of practically infinite individual nucleotides becomes a series of extremely plausible genetic sequences directing and organizing the intercellular structure into what we see today.
I LOVE the complexity of the video, sounds, images, voices, frames..., keep doing them like that
Lyrics, your welcome! :
EVO-DEVO
Huxley
B. Mac
Oh Carroll, Carroll
Gould, Stephen Jay yeah
D-D-D-D-Davidson and Peter
See
One cell divide and decide on a thousand fates
Did you ever figure how they know?
B. Mac
We
Are built of modules combined in a planned out way
Each new piece must be told where to go
Oh
Now there's a science helping us to understand
How our cells encode this architectural plan
Signalling each other with genetic tools oh
Oh yeah
Wow
Phenotype the interface for mouse and man
Genotype the files and the subprograms
What then are the switches, circuit boards and boot code?
Evo-Devo
Looking at the logic in the ways that we grow
Every gene directed by a signal key code
Proteins that can activate, enhance or veto
Evo-Devo
Signals are controlled by other genes that signal
Calculating in a network labyrinthal
Where the heart and liver and the hands and feet go
Signal mapping tells each region what it ought to be yo
With circuits so deeply built upon
They're older than the Paleo
The Paleozoic Era baby
In a crucial pathway changes tend to get torpedoed
Where they go calamity goes
As this cyclopic sheep knows..
See down they cascade like a domino
Like you and I drosophila
The path that makes us optical
Was laid a long long time ago
Back before we blew up the cambrian like a bomb bomb
Now my eye protein can make you see out of your bom bom
And Hedgehog and its relatives like Indian and Sonic
Set up set up in a gradient on segments embryonic
Split forebrains and asymmetric parts depend upon it
Flipping on genetic switches and logic
From devo to evo
Adult and embryo
Mostly don't evolve in the genes of the genome
Safer the mutation aimed at regulation
Keep the building blocks and swap their activation
From devo to evo
Parts have alter egos
Homologs evolved from repeats in the schema
Switch a couple bases in the proper places
You'll be watching flies grow legs out of their faces oh yeah
Evo-Devo
Stick around for Modern Synthesis the sequel
Only by combining can a new theory grow
Evolution and development amigos
Evo-Devo
Signals trigger patterns of complexity so
Switching up the switches of a signalling node
Gives a modular and simple way to evolve
Look at how our spinal segments generate a neat row
Built on a molecular clock
One cycle, one vertebra
One vertebra one vertebra baby
Speeding up its rate is snakes' developmental cheat code
That and where a lizard's feet grow
They turn off distal aminos
Evo-Devo
This is how we go from single cells to people
Every generation and in life primeval
Life in variations endless and beautiful
Badaboom
From devo to evo
Larva to mosquito
Patterns are resolved as the signals proceed yo
Map out a gene with a glow tag
Kill it with a morpholino
Short oligo morpholino baby
From devo to evo
Voyage of the Beagle
Body plans evolve when proteins steer the genome
In this manner life's beauty grows
Aesthetica in vivo
Evo-Devo
Hey, you just copied it from description.!
Ever heard of captions?
Absolutely Fantastic, How do you do it, you are Mozart with the mind of Einstein.
Perfectly stated...a fantastic Einstein, involving brilliant patrons.
Just saw him perform this live at a science fest and it took me back to my undergrad days when I was obsessed with his content. He was too good on stage! Loved his live performance
Oh my, I never comment on UA-cam but man, this is beyond art, this is beyond imagination, this is beyond any other form of music. The production quality of this song video is nuts, and the idea and execution are pure genius. Thanks for giving this masterpiece to humanity. I hope it will live forever, and be preserved by all means possible for future generations.
Syncronized the audio with Despacito. Fits perfectly
Because you said it, I had to try it. Not all the syllables mesh perfectly (as one would expect with different languages), but I am flabbergasted by the otherwise perfect synchronization! That was one heck of an experience once I did get it synced! Thank you for enlightening my afternoon!
You are very much welcome my friend. You should try this test with any parody with its original
I also checked, and I confirm: The best video on youtube have been found.
As a developmental biologist, I cannot like this enough! If there are any questions, please reply here and I'll try to answer when I have time!!
So, I only know the basics of the eukaryote's gene regulation and the song is already hard to get in it's entirety as English isn't my native tongue and the vocabulary used is quite specific.
Did I get it right that, taken from the pic at 1:20, signals from enhancers and silencers work somewhat similar (yet way more complex and with translation-products) to summation in neurophysiology?
It seems a pretty complex and fragile system to me, how doesn't it collapse instantly when a part of it suffers a mutation that isn't detected by respective proteins?
I'm sorry if those questions might seem a bit confusing, I haven't had genetics in a while, but I'd be happy if you found time to answer them.
Great questions! (1) Regarding the complexity, there are even greater levels of control in gene interaction networks beyond enhancers and silencers to activate/repress genes that are collectively called the epigenome. Part of the control of gene expression is regulating whether or not the DNA is accessible and can recruit the enhancers/silencers in the first place. Let me know if you'd like more info on this!
(2) Regarding the collapse of these networks due to mutations: I think you're basing your assumption on two points: (a) a mutation happens in a specific site and (b) that site does not tolerate any ambiguity or change. First, the mutation rate in human somatic cells is estimated to be one to two mutations per division. Seems like a high rate right? But when you consider the human genome is approximately 3 billion base pairs in its entirety, the chance of a mutation striking a key regulatory element is astronomically small (especially when you're looking for something to happen to a progenitor cell during development). Second, many of the DNA binding proteins that activate/repress/enhance/silence genes can tolerate varying degrees of ambiguity in the sequence they bind to.
I'm a botanist with a solid molecular biology background so a lot of this makes sense to me. I've been fascinated with evolutionary processes for some time also. I am wondering what kinds of classes should be teaching evo-devo in detail. Also it does strike me as a little weird that the urbilaterian would be both relatively complex and old, but maybe I'm just underestimating the complexity of little things. :)
wanderingazn please is the darwinien theory of evolution true and give me some simple proof im just a high school student
Veryde, I can’t seem to see your reply for more info on Epigenetics. Do you still want to hear more?
Listened to this on loop before my AP Bio presentation as a hype song. Got an A. I put that grade all down to this song.
3 years later and this song still slaps
I was wondering when a Despacito parody was coming. Incredible as always!
trebledawson Hi, i made an amazing science rap battle. you wud love to hear. Plz check it on my channel. Do give your valuable feedback.
How did I only now notice, that the beginning of this video is a continuation of 'Molecular Shape of You'?
In the words of Carl the Llama, you win the prize: I didn't even notice that one. =D
Easter egg! Good spotting.
anyone kind enough to upload them back to back in a single video?
Ask Tim.
This. THIS magnificent piece is why we have Fair Use. I think I like this better than the original it's parodying?? Also this is probably the most directly educational parody I've ever heard!
And just think of how many other people over the course of thousands of years working hard and observing and turning over ideas it took just to get the BASIS of this song, either scientifically or musically. A billion years of evolution and a few thousand of examining our own world with curiosity in depth... to create this beautiful, melodic, lyrical piece using ONLY human voice...
Frickin. Humanity!!! We're kinda neat 💖
They should show this in High School bio classes. I learned a crazy amount by just rewatching this & getting it stuck in my head.
I love well you give your lyrics the same rhythm as the original ones, many parodies fail to do that and end up worse for it!
Listening to this song brings me tears of pure joy. Aesthetica in vivo.
My eyes water up everytime I listen to this :)) it's so beautiful!
I couldn't agree more with you two ! ! !
YEP!
3:13 "This is how we go from single cells to people / every generation and in life primeval / life in variations endless and beautiful". This moment always gives me goose bumps. It's made me cry before. Beautifully written.
This man needs to be protected at all costs, he just told us the structure of life in a couple minutes
Why can I only like this once? You are a freaking genius! Your musicality is phenomenal and your scientific explanation is perfect!
Guys I think UA-cam is broken...It says that this video has 367k views but I'm pretty sure I've seen it more times than it!!!
same!
4:45 per view, and you say 367k views. that makes 3.31448634 years, according to google. i will take off one month from the publishing time, making 60 days into 29 days. 3.31448634 years / 29 days is 41.716810831(ish). so even if 41 people had been watching it constantly since it came out, that would only just make 367K views.
Dont post bad comments on a clever people channel
949k
Matthew Shaw It was a joke my man
Chill😂😂
Matthew Shaw yo wtf, calm down 😂😂😂
I was introduced to this song in Gen Bio in 2019. Five years later I am a third year Biomedical Sciences PhD Candidate and still watch it every few months. It helps me remember why I fell in love with Biology and want to spend my life in research, when that's not always easy to remember in the midst of failed experiments. Thank you for this gift that keeps on giving!
My evolution professor at uni played this in class before our evolutionary development lecture. I absolutely love how you conceptualize the amazing process that is evolution. Knowing the specifics of gene regulation and development just makes it so much better