Hi folks! Let me know your thoughts on the video, or anything else 😀 Do you think that intensive fasting is something that you would try? If you have done it, have you noticed any improvements in chronic illnesses?
I’ve practiced intermittent and extended fasting from March 2022 to the present (2023) and no longer have shoulder, knees or other joint pain or stiffness. I usually fast 20 hours and occasionally extend my fast to 36 , 48 and 72 hours. My longest fast was 113 hours .
Prolonged fasting isn't just for short periods. I was doing research when a dear friend was diagnosed with lung cancer and I found quite a few cases of people 'curing' their cancer by doing extended periods of liquid fasting, up to 20 days or more, along side chemo treatments. In one case, a 70 year old man with stage 4 metastatic lung cancer went into total remission after just 5 months of extended fasting, alternating with periods of eating a healthy keto diet. I personally practice intermittent fasting 18 hrs per day, with a 48 hr fast about once per month. That along with a low sugar/low carb diet and a few high quality supplements has completely transformed my life. I have cured ALL of my health problems (high blood pressure, high cholesterol, high blood sugar, 60 pounds over weight, etc). I am now 53 and in the best health of my life, and I still don't eat a perfect diet, although it's much better than it use to be. Fasting works!
Could an up regulation of immune activity, not also be interpreted as a downstream response to perhaps increased viral activity? As in how do we know that the fast isnt perhaps allowing previously kept incheck viruses to proliferate, due to maybe metabolic suppression or similar, and therefore generating a immune response? I have no formal training in this, and no reason to suspect this is the case. I am just offering it as a hypothetical so I can understand the epistemological reasons that we know this immune is entirely for desirable reasons. ...if that makes sense?
It is definitely an interesting question to consider! From what I know of fasting, it does not degrade the immune response, it only makes it run more efficiently. Latent viruses usually activate when the immune system is weakened and not working optimally. Furthermore, in the volunteer population some of the screening criteria used usually excludes people with chronic infections or general disease.
Very interesting, as usual! So they discovered that fasting increases neutrophil presence and enhances their function while decreasing lymphocyte presence and cellular apoptosis. What effect does this have on the host? Is it beneficial for immunity? If so, wouldn't the host just use these mechanisms all the time? Or maybe these are just energy-saving mechanisms and have a neutral or even negative effect on combating microbes? Just generally enhancing neutrophil activity, not in response to infection, is not necessarily beneficial if the enhanced inflammatory activity is occurring in a sensitive location (gut or heart) or if it could cause chronic inflammation or even autoimmunity? Am interested to hear your thoughts! :)
As far as the data presents itself, there are no major negative consequences for the host (besides having hunger and likely lethargy). This is likely in part because you cannot do intensive fasting forever, you need to resume a diet. Even so, there are numerous benefits from an intermittent fasting schedule maintained for months or even years which include reducing chronic inflammation and autoimmune symptoms. All sources that I have seen indicate that fasting is beneficial for immunity. This state needs a specific lack of other nutrients to kick itself into overdrive, so by eating normally your body cannot jump-start this process to the same degree. Neutrophils are more activated, but not every process in the neutrophils are being activated (only degranulation). It is possible that some functions could be deleterious in certain locations, but I do not think that it is that much of an issue because the healthy cells also get more resilient in the face of scarce resources because they NEED to.
@@InvestigateExploreDiscover Thank you; interesting reply! I just found your channel from the immunology subreddit and have been watching your videos! :)
Great question! I do not think it has been tested yet, but It is definitely something that I would like to see tested. Since there is evidence that HPV downregulates autophagy, It would be fascinating to see if up-regulating autophagy through fasting would help to get rid of hpv in cells!
I got hpv. When i get cancer Will it benefit me to fast for autophagy or Will it kill me? Since hpv take over autophagy? Or can i kill the cancer with fasting then?
I do not think that it will be detrimental for you to fast regardless if you have hpv. However, for specific personal health related questions you should consult with your doctor.
Mate I love your videos but unless your target audience are scientists when you talk about 'neutrolphil degranulation signatures' you may as well be speaking Swahili, lol.
![Fasting & Inflammation: A Story of Autophagy? [Science Explained]](/img/n.gif)
Hi folks! Let me know your thoughts on the video, or anything else 😀
Do you think that intensive fasting is something that you would try? If you have done it, have you noticed any improvements in chronic illnesses?
I’ve practiced intermittent and extended fasting from March 2022 to the present (2023) and no longer have shoulder, knees or other joint pain or stiffness.
I usually fast 20 hours and occasionally extend my fast to 36 , 48 and 72 hours. My longest fast was 113 hours .
Prolonged fasting isn't just for short periods. I was doing research when a dear friend was diagnosed with lung cancer and I found quite a few cases of people 'curing' their cancer by doing extended periods of liquid fasting, up to 20 days or more, along side chemo treatments. In one case, a 70 year old man with stage 4 metastatic lung cancer went into total remission after just 5 months of extended fasting, alternating with periods of eating a healthy keto diet.
I personally practice intermittent fasting 18 hrs per day, with a 48 hr fast about once per month. That along with a low sugar/low carb diet and a few high quality supplements has completely transformed my life. I have cured ALL of my health problems (high blood pressure, high cholesterol, high blood sugar, 60 pounds over weight, etc). I am now 53 and in the best health of my life, and I still don't eat a perfect diet, although it's much better than it use to be. Fasting works!
I try to fast on weekends, I have ulcerative colitis, and started reading the Bible, fasting is significant in prayer as well
On day 5 of 40 days for healing enlarged necrotic lymph node from SCC
Great information brother. Thank you 🙏
Greetings, great video, today is my 28th day of no good on a lemon regimen, lemon and maple syrup, I'm still feeling great
Greetings, great video, today is my 28th day of no FOOD on a lemon regimen, lemon and maple syrup, I'm feeling great !!!
Could an up regulation of immune activity, not also be interpreted as a downstream response to perhaps increased viral activity?
As in how do we know that the fast isnt perhaps allowing previously kept incheck viruses to proliferate, due to maybe metabolic suppression or similar, and therefore generating a immune response?
I have no formal training in this, and no reason to suspect this is the case.
I am just offering it as a hypothetical so I can understand the epistemological reasons that we know this immune is entirely for desirable reasons.
...if that makes sense?
It is definitely an interesting question to consider!
From what I know of fasting, it does not degrade the immune response, it only makes it run more efficiently. Latent viruses usually activate when the immune system is weakened and not working optimally. Furthermore, in the volunteer population some of the screening criteria used usually excludes people with chronic infections or general disease.
Iam thinking the same since Hpv hijack autophagy. Will it kill me to fast
Very interesting, as usual!
So they discovered that fasting increases neutrophil presence and enhances their function while decreasing lymphocyte presence and cellular apoptosis. What effect does this have on the host? Is it beneficial for immunity? If so, wouldn't the host just use these mechanisms all the time? Or maybe these are just energy-saving mechanisms and have a neutral or even negative effect on combating microbes? Just generally enhancing neutrophil activity, not in response to infection, is not necessarily beneficial if the enhanced inflammatory activity is occurring in a sensitive location (gut or heart) or if it could cause chronic inflammation or even autoimmunity?
Am interested to hear your thoughts! :)
As far as the data presents itself, there are no major negative consequences for the host (besides having hunger and likely lethargy). This is likely in part because you cannot do intensive fasting forever, you need to resume a diet. Even so, there are numerous benefits from an intermittent fasting schedule maintained for months or even years which include reducing chronic inflammation and autoimmune symptoms.
All sources that I have seen indicate that fasting is beneficial for immunity. This state needs a specific lack of other nutrients to kick itself into overdrive, so by eating normally your body cannot jump-start this process to the same degree.
Neutrophils are more activated, but not every process in the neutrophils are being activated (only degranulation). It is possible that some functions could be deleterious in certain locations, but I do not think that it is that much of an issue because the healthy cells also get more resilient in the face of scarce resources because they NEED to.
@@InvestigateExploreDiscover Thank you; interesting reply!
I just found your channel from the immunology subreddit and have been watching your videos! :)
Would this benefit to get rid of hpv?
Great question!
I do not think it has been tested yet, but It is definitely something that I would like to see tested.
Since there is evidence that HPV downregulates autophagy, It would be fascinating to see if up-regulating autophagy through fasting would help to get rid of hpv in cells!
Thats what i was thinking aswell. + Fasting boosts immunsystem.
I got hpv. When i get cancer Will it benefit me to fast for autophagy or Will it kill me? Since hpv take over autophagy? Or can i kill the cancer with fasting then?
I do not think that it will be detrimental for you to fast regardless if you have hpv. However, for specific personal health related questions you should consult with your doctor.
Mate I love your videos but unless your target audience are scientists when you talk about 'neutrolphil degranulation signatures' you may as well be speaking Swahili, lol.