The Complement System: Classical, Lectin, and Alternative Pathways

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  • Опубліковано 16 січ 2025

КОМЕНТАРІ • 223

  • @Liberperlo
    @Liberperlo 2 роки тому +344

    This is the best video on complement I have seen. I'm not an immunologist or even a student. Just a librarian who is fascinated by the immune system. Thanks!

    • @Fidel5555
      @Fidel5555 2 роки тому +42

      Wow! You've inspired me...I'm a medical student and find this stuff boring yet you're not even a student but study immunology voluntarily, congrats

    • @spvillano
      @spvillano 2 роки тому +6

      @@Fidel5555 I've always said, I'll stop learning maybe, just maybe three days after I'm dead. ;)
      No reason to not study various things, as knowledge is power.
      Back when I was in the Army (retired in 2010), I ran into not one, but two cases of pheochromocytoma. One was recognized late, the soldier was to begin treatment after field training, but expired from a ruptured AAA. The other, I pieced together what was going on, asked doctor to do me a favor and run a couple extra tests and there it was, he had pheochromocytoma. His problem was quickly addressed and he returned to duty. So, that trivia can and does save lives. Diagnosing things, just Boolean flow really.
      I do Boolean algebra and regular expressions in my head as part of my job. :)
      Annoyingly, basic math tends to give me trouble, but that's what calculators or if I had to, fall back to a slide rule is for.

    • @Dannalasapa
      @Dannalasapa 2 роки тому +1

      @@Fidel5555 same this is the class I’m hating the most so far but I think it’s mostly bc my prof is absolutely awful

    • @bjrnaaron
      @bjrnaaron Рік тому

      Beautiful ❤

    • @IPlayAces
      @IPlayAces Рік тому +1

      couldn't agree more- coming from a physician/scientist who's heard many (attempted) explanations of complement systems. this is pure gold. never heard such a clear cut explanation

  • @alemantewassie6695
    @alemantewassie6695 9 місяців тому +5

    This was the best video I have ever watched about Complement system. Only someone who have left a few minutes left to cover this topic knows how fantastic this work is. Thank you Prof Dave.

  • @emdoubleyew3788
    @emdoubleyew3788 3 роки тому +86

    This makes re-reading my immunology textbook nearly painless. Lovely stuff you have.

    • @spvillano
      @spvillano 2 роки тому

      This and similar courses makes things a lot easier to recognize hydrophobic parts and lipophilic parts of some carbon chains. That helps me understand some odd points in the pharmacology of some medications.

  • @sumeet9367
    @sumeet9367 2 роки тому +98

    Professor Dave, I am an MS1(first year medical student) and my first block includes immunology. I wanted to say your videos including this complement protein video are more concise than the lectures from my immunology professor. Thank you!

    • @its_not_lux
      @its_not_lux 8 місяців тому +2

      nibba you didn't have to say anything other than 'first year med'. MS1😵‍💫

    • @anoud6059
      @anoud6059 4 місяці тому

      Same

  • @Hannah-yz7gj
    @Hannah-yz7gj 2 роки тому +11

    you don't know how much you helped me understand this topic. i was on the verge of crying going through our readings but this video really clarified a lot of things (for some reason it seemed like our lecturers were also speaking a whole different language while teaching this). thank you so much!

  • @MissD333
    @MissD333 Рік тому +7

    This is really excellent. Also the speed at which you speak is perfect for people who are trying to understand something, other videos I have to pause and re listen because they’re talking too fast, but this is perfect!

  • @Sydney-gk8gh
    @Sydney-gk8gh 5 годин тому

    This is by far the most clear yet comprehensive breakdown of these pathways that I have seen. Thank you so much, you just tied together so many loose ends from days of studying!

  • @almaalcala3887
    @almaalcala3887 2 роки тому

    Thanks!

  • @dmskarunaratne80
    @dmskarunaratne80 2 роки тому +3

    no words. simplistic way to teach complex theory with best illustrations. thank you. Best video on this topic.

  • @bethuelmutiti2089
    @bethuelmutiti2089 2 роки тому +17

    I really don't know how my Med School would be without you sir 😭🙏❤️🔥. A Big thanks to you for making my life easy

  • @whbclaire
    @whbclaire Рік тому +2

    Thank you so much for this. In my role as a medical writer, I have been doing some programs on paroxysmal nocturnal hematoglobinuria, which is a disease of the complement cascade. This clearly explained a lot of the things I was confused about.

  • @shaqthedoc4376
    @shaqthedoc4376 3 роки тому +4

    dude you just cleared the evolutionary aspect of the complement system, great job👍🏻

  • @zhaomengna4800
    @zhaomengna4800 2 роки тому +5

    Very detailed and direct illustration and description. Learn more from these lectures. Thanks a lot.

  • @immune01
    @immune01 8 місяців тому +1

    Very comprehensive with just enough detail for competence but not too overwhelming!

  • @ValeriaSteiger
    @ValeriaSteiger Місяць тому

    Thank you soooo much, seriously! After studying medicine for 4 yrs i did not just learn it by heart, but understood it

  • @madelinegreene8031
    @madelinegreene8031 2 роки тому

    I have an immunology test next week for my first year of grad school--this has been SO much more helpful than anything my professor has said!

  • @sagacious_Codyt
    @sagacious_Codyt 2 роки тому +1

    This has been really helpful. I've been struggling to understand the complement cascade but with how you've laid everything out, I'm subliming..
    .. Thank you so much

  • @AlvinturesTV
    @AlvinturesTV 3 роки тому +10

    Just on time for my quiz on this topic!

  • @GolgiGuy102
    @GolgiGuy102 Рік тому +3

    I really appreciate the evolutionary context. Really outs things into better perspective!

  • @birukgossaye2187
    @birukgossaye2187 3 роки тому +7

    Hey Professor, I understand almost everything you explain so please start makin videos about music theory and all. You're the best teacher ever.

    • @samgas1219
      @samgas1219 3 роки тому

      He knows alot about the SCIENCE stuff, unfortunately music theory is not a science.

  • @pamtarlow
    @pamtarlow Рік тому

    Great video. I am a pharmacist trying to help my patients with Long Covid and appreciate the excellent education here.

  • @Paraselene_Tao
    @Paraselene_Tao 3 роки тому +53

    I'm so glad that you're making these lectures. I considered months ago that the US population (from high school and up) needs to learn how the immune system works. If we know how the immune system works then we will all understand and agree on something like a vaccine. Thank you for spreading this information.

    • @spvillano
      @spvillano 2 роки тому

      Indeed, the problems with COVID seems to be that leukocytes are being infected, interfering with their response, while innate responses are also being blunted. By the time the immune system notices that the infection was unaddressed, it went into scorched earth mode (to oversimplify it by a lot) and that's the cytokine storm of COVID-19 and the Spanish Flu.

    • @whbclaire
      @whbclaire Рік тому

      You are so spot on! If more people understood immunology, we would haver far fewer ridiculous conspiracy lies circulating about vaccines!

  • @ferhanslamang370
    @ferhanslamang370 2 місяці тому

    I had no idea where all these complement proteins came from, but you simplified it really well for me.

  • @adamhartz5483
    @adamhartz5483 3 роки тому +3

    Professor Dave.... This video is great. It helped me understand the video much better.

  • @genero2008
    @genero2008 26 днів тому

    Easy but comprehensive lecture. the best of the best to me.

  • @marinahovakimyan9387
    @marinahovakimyan9387 2 роки тому +4

    Thank you so so so much! Amazing explanation and illustration! Thank you for your effort.

  • @wassyjalal8447
    @wassyjalal8447 Місяць тому +1

    I used to watch your videos way back in high school for AP bio and your videos are still carrying me as a first year medical student lmaooo. Could not have made it where I am today without you

    • @ProfessorDaveExplains
      @ProfessorDaveExplains  Місяць тому +1

      email me a video summarizing this in 10-20 seconds for my upcoming 10th anniversary video!

  • @kedarnathlivedarshanbhakti9715

    Saw so many videos.. But finally got clarity in this one

  • @studyvlogcute
    @studyvlogcute 2 місяці тому

    it was great. thank you, i really had a problem undrestanding complement system but you made it so easy to undrestand.

  • @basiabarbara3365
    @basiabarbara3365 3 роки тому +6

    Your videos are so helpful to me, thank you🙏🏻

  • @ClashergodClashergod
    @ClashergodClashergod 10 місяців тому +1

    great video

  • @nouf1406
    @nouf1406 Рік тому +19

    How am I supposed to memorize all of this?

    • @Abderrahmane-zq3bw
      @Abderrahmane-zq3bw 3 місяці тому +2

      it’s FAR better than those long azz med school lectures… mine is literally 100 slides

  • @palantir135
    @palantir135 3 роки тому +2

    I had to learn all this a long time ago. Thanks for the update.

  • @robjoemama2466
    @robjoemama2466 11 місяців тому

    Excellent video!! I have a better understanding of the Complement system now. I'll recommend this to my classmates to watch. 👏👏👏👏👏👏👏👏👏👏

  • @reeveeakt7250
    @reeveeakt7250 3 роки тому +3

    Animal immune system are really well made... Amazing presentation!

  • @samreenkomal3837
    @samreenkomal3837 Рік тому

    I've been a subscriber since 2016. It's amazing how easy you make things seem easy for us❤❤❤ Lots of love Professor!!❤️

  • @allofme835
    @allofme835 2 роки тому +2

    Love your teaching skills to visual learners. You make studying easier 🥳🥳

  • @abigailwatson3330
    @abigailwatson3330 2 роки тому

    Thank you thank you thank you, was not understanding this from textbooks or my lecturers! your videos are the best!

  • @beaniebaby_rei
    @beaniebaby_rei 3 роки тому +1

    You're a God send

  • @TikoPiko
    @TikoPiko 3 роки тому +4

    @Professor Dave Explains, I have come to purchase your book through my enjoyment of your UA-cam content. I must say that I find it very insightful, succint and a refreshing read overall. I look forward to more from you, as you definitely posess great talent.
    P.S.: on page 18 there is a helium atom representation with the subtext implying that it is in colour, when in fact at least my edition is grayscale. Just a (hopefully) helpful note.

  • @nuriatnamatovu
    @nuriatnamatovu Рік тому

    Just the best I heard about the compliment system , long live

  • @jessicalv6442
    @jessicalv6442 Рік тому +1

    Save my life!!! Thank you!!!

  • @josephntowannobil4571
    @josephntowannobil4571 11 місяців тому

    Superb explanation on Complement System. I love this video

  • @PRAGNAGOLDER-d9x
    @PRAGNAGOLDER-d9x 27 днів тому

    Nicely explained! May God bless you.

  • @zarghunarakheel3829
    @zarghunarakheel3829 4 місяці тому +1

    It's strange how Years of crazy cramming could be resolved one simple vedio.. you did a great job here.

  • @StoutShako
    @StoutShako 3 роки тому +1

    WOOOO YEAAAH, BABY THAT'S WHAT I'VE BEEN WAITING FOOOOR WOOOO!

  • @santicruz4012
    @santicruz4012 3 роки тому +3

    Thanks professor Dave!

  • @djmaamis3167
    @djmaamis3167 Місяць тому

    I'm m1( first year medical student)
    Sir you are helped me alot in my immunology module ❤🎉

  • @karina3133
    @karina3133 Рік тому

    Extremely good video about Complement, saved me. Thank you!

  • @moon_loverr
    @moon_loverr 2 роки тому +1

    Your videos are amazing, makes immunology easier, making my day😊 Thanks Professor wish u all success.

  • @equalizerz3107
    @equalizerz3107 Місяць тому

    Great job professor !! so beneficial

  • @balamicroworld7
    @balamicroworld7 Місяць тому

    Thank you so much 🙏🏻.You explain so well.

  • @AndzileDlamini-ju4yw
    @AndzileDlamini-ju4yw 5 місяців тому

    I just paused the video to tell you that you a legend Professor Dave🤝🙏🐐

  • @Sabrinaaa_97
    @Sabrinaaa_97 19 днів тому

    شكراً جزيلاً ❤❤❤

  • @XtinaThaiFan
    @XtinaThaiFan 3 роки тому +3

    This is amazing. Thank youuuu 😍❤❤

  • @1rrrrrrrrrrr544f
    @1rrrrrrrrrrr544f 6 місяців тому

    Can't be explained better ❤❤❤❤

  • @umanamicheal8089
    @umanamicheal8089 9 місяців тому

    Oodles of thanks, Professor Dave.

  • @Lulla3sl
    @Lulla3sl Рік тому

    BEST EXPLANATION EVER!!

  • @shria__7870
    @shria__7870 Рік тому +1

    really made such an intimidating topic so easy to understand! thank you Professor Dave :))

  • @ahmedeldimllawi5092
    @ahmedeldimllawi5092 Рік тому

    ur awesome and this is the best video on complement i have seen

  • @user-cj8bu7qq4o
    @user-cj8bu7qq4o 2 роки тому

    Great presentation on complement pathway!

  • @danjbro
    @danjbro 3 роки тому +2

    Well done Dave! 👏🏽

  • @datimbangnorminah1956
    @datimbangnorminah1956 2 роки тому

    Thank you for helping me learn our lesson in Serology

  • @zahrap906
    @zahrap906 Місяць тому

    really excellent video,thanks so much❤

  • @theadorablea7469
    @theadorablea7469 2 місяці тому

    there is no video in german, which explains it so well, thanks!!

  • @BokangMofomme
    @BokangMofomme Рік тому

    This amazing! and easily to follow, thank you prof Dave

  • @lexthevi
    @lexthevi Рік тому

    Damn
    Man just explained the gibberish in my Professor's slide perfectly.
    Ready for this exam now.

  • @craigcooper5060
    @craigcooper5060 2 роки тому

    Really good review of the complement system...
    Thanks for posting!

  • @synasanchouli8511
    @synasanchouli8511 3 роки тому +1

    Your videoes better than faradars immunology course

  • @umanamicheal8089
    @umanamicheal8089 9 місяців тому

    Very explicit and comprehensive.✌️👍👍

  • @israelojo6875
    @israelojo6875 Рік тому

    Excellent sir. You are doing extremely well. This is really great and highly explanatory, infact completely.

  • @il3354
    @il3354 2 роки тому +1

    Very well explained. Thank you!

  • @nadernayo
    @nadernayo 3 роки тому +1

    Thanks...Great knowledge..

  • @codeyds6769
    @codeyds6769 Місяць тому

    As a first year medical student, thank you.

  • @chihchengh
    @chihchengh 3 роки тому +3

    Really good!

  • @mayar9078
    @mayar9078 3 роки тому +1

    Great explanation , thanks 💕

  • @zahramashhadi4288
    @zahramashhadi4288 2 роки тому +1

    It is very helpful. thank you so much

  • @drmadhavmehta
    @drmadhavmehta 9 місяців тому

    Great video Professor!

  • @santanudebnath9617
    @santanudebnath9617 10 місяців тому

    You're doing really good. Best wishes

  • @sarahmsoh5482
    @sarahmsoh5482 2 роки тому

    How can one fail to subscribe. Best video on Complement

  • @minashin1562
    @minashin1562 Рік тому

    My man has the best intro ever 👍

  • @janeszz
    @janeszz 3 роки тому +3

    Hey, really like your videos, especially the ones where you debunk conspiracy theories. I recently saw something about Tesla's radiance energy curcuit. It is suggestet that this would be able to supply everybody with free energy but companies dont want us to know about it because we should pay for their energy. Maybe that could be a video idea. Keep on the great work!

  • @PahlaChenjerai
    @PahlaChenjerai Рік тому

    this vid is superb, it's best for understanding

  • @mahkishouma314
    @mahkishouma314 2 місяці тому

    thanks a lot! i watched it twice

  • @Sciencstudent
    @Sciencstudent 10 днів тому

    Thank you sir so much, this video was vary helpful

  • @ubaidullah1611
    @ubaidullah1611 2 роки тому +1

    Wow loved it

  • @dohagouyd3997
    @dohagouyd3997 2 роки тому

    I would like to give you a huge thank for this video! you saved me fr

  • @sonasunil1748
    @sonasunil1748 5 місяців тому

    Hey one teeny tiny mistake that caught my eyes :- C3 convertase = C4b2a ryt? It shows 2b ( 4:37). Great video. Keep posting!!❤❤

  • @sandaruariyawansa6765
    @sandaruariyawansa6765 2 роки тому +1

    Thank you so much for the explanation!

  • @arunshankar814
    @arunshankar814 6 місяців тому

    Awesome video 👌

  • @akubasco
    @akubasco 2 роки тому

    thanks for making this video.Very helpful.

  • @saswatipatra
    @saswatipatra 8 місяців тому

    Can't thank you enough..🙏🏼

  • @fatimayasir9115
    @fatimayasir9115 2 роки тому +1

    Really great job, thanks a lot!

  • @teresajadia3291
    @teresajadia3291 2 роки тому +2

    I am a licensed medical technologist and I'm studying for my second license this coming October. Complement system always ALWAYS aggravate the shit out of me. This lecture gave me atleast an idea what to remember 😅

  • @SaeedaKuvadia
    @SaeedaKuvadia Рік тому

    better than my uni lectures!!

  • @زهراءالدليمي-ي8ح

    Thank you very much❤❤

  • @relinamohamed5090
    @relinamohamed5090 3 місяці тому

    Thank you so much!

  • @heathercollazo5203
    @heathercollazo5203 2 роки тому

    Professor Dave for President 😸

  • @RfR442
    @RfR442 Рік тому

    Prof for a reason

  • @sishabell8474
    @sishabell8474 2 роки тому

    Thank you professor ✅👍🏻