Bone metastases - One Disease with Many Signs

Learning points:
The distribution of metastases is determined by the locations of stem-cell niches and BM stromal cells including regulated fat cells
The balance between osteoblastic and osteolytic mechanisms determines the nature of the metastases observed on x-ray methods
Combining appearances on MRI with CT enables an expanded classification of bone metastases according to their underlying cellularity & matrix appearance
The BM cell signalling status of bone metastases can be inferred from MRI/CT/bone scan appearances

[@rogerembry4777]

I don’t understand any of this

[@anwarpadhani]

Look at the playlist on metastases where I break it down into 3 sections. That should help you

[@cocoann7681]

Thank you i have agressive breast cancer and my knees and shin bones hurt so bad it makes me cry

[@EmranAskari]

Very thought-provoking classification. 👏
Had to see the video twice!
One Question: 🤔
If cancer cells first manipulate the osteoclasts and the progenitors of fibroblasts are the same as osteoblasts, is it correct to say that the early phase of marrow involvement for metastatic prostate cancer would be like this:
PSMA-PET: +
Bone scan: -
FDG-PET: + (osteoclastic phase, if agressive phenotype and high GG)
FAPI-PET: - (my main question)
WB-MRI: -/+ (not hypercellular yet, similar to osteoclastic-only activity in the fat-predominant phenotype)
CT: mildly hypodense, yet not lytic

[@NicoleNatour]

GREAT TALK!!!! thank you very much

[@testos2701]

WOW, great information, there is so much knowledge out there is incredible!

[@anwarpadhani]

Glad it was helpful!

[@bookbeing]

If a ct scan reveals osteolytic and osteoblastic lesions along vertebral areas, is this a indicating mets?

[@anwarpadhani]

Yes. If there's a history of Cancer

[@shardapurohit5225]

❤