Regulation of Receptors (Downregulation & Upregulation) Pharmacodynamics Part 14 | Dr. Shikha Parmar
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- Опубліковано 14 жов 2024
- Regulation of Receptors (Downregulation & Upregulation) Pharmacodynamics Part 14 by Dr. Shikha Parmar
Pharmacology is all about the study of drug and their effect on the body along with the body responsible for the drug taken. The drug gives its action mainly through the receptor.
Receptors are the macromolecule or binding site located at the surface or inside the cell. They are used to recognize the signal or drug molecule and initiate the biological response. The biological response is generally given by any drug using any of these mechanisms- (1) Enzyme (2) Ion channels (3) Transport (4) Receptor. In biochemistry and pharmacology, a receptor is a protein molecule that receives chemical signals from outside a cell. When such chemical signals bind to a receptor, they cause some form of cellular/tissue response, e.g. a change in the electrical activity of a cell. A receptor is a protein which binds to a specific molecule. The molecule it binds is known as the ligand. A ligand may be any molecule, from inorganic minerals to organism-created proteins, hormones, and neurotransmitters. The ligand binds to the ligand-binding site on the receptor protein. When this binding happens, the receptor undergoes a conformational change. This change shapes slightly alters the protein’s function. From this, a number of things can happen. The conformational change in the receptor can cause the receptor to become an enzyme and actively combine or separate certain molecules.
Description Source: Wikipedia
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Essentials in Medical Pharmacology by KD Tripathi
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Lekin Hindi me bhi agr thoda explain krti to best hota