The ‘TRUTH’ About Dopamine - The Neuroscience Behind Your Brain's Reward System
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- Опубліковано 15 вер 2024
- In this video, Dr. Sanil Rege, a consultant psychiatrist, sets the record straight on dopamine. You've seen the buzzwords: dopamine hacking, stacking, fasting. But what do they really mean? And why do they often miss the mark?
Dr. Rege breaks down the complexities of dopamine and its role as a crucial neurotransmitter. Forget the oversimplifications; he dives deep into:
1. The Evolution of Dopamine
2. The Discovery of Dopamine's Role in Medicine
3. Common Misunderstandings and the True Role of Dopamine
4. The Risks of Focusing Too Much on Dopamine Optimization
5. How to Improve Well-being Through a Scientific Understanding of Dopamine
6. A Sneak Peek into Narcissism and Dopamine Levels
If you think dopamine is just the "feel-good" button, you're in for a surprise. Dr. Rege explains how this neurotransmitter shapes our behavior, cognition, and activity. He explores the evolutionary journey of dopamine, from motility in ancient organisms to its critical functions in the human brain.
You will also learn about the intricate balance required for optimal dopamine function and why simple hacks don't work. Plus, find out whether individuals with narcissism have low or high dopamine levels.
Join Dr. Rege as he unravels the science behind dopamine, its impact on mental health, and practical ways to enhance your well-being. Don't forget to like, comment, and subscribe to "Psychiatry Simplified" for more insights into the fascinating world of psychiatry and neuroscience.
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#PsychiatrySimplified, #DrSanilRege, #Dopamine, #Neuroscience, #Neurotransmitter, #DopamineOptimization, #RewardPredictionErrors, #EvolutionaryBiology, #BasalGanglia, #PrefrontalCortex, #DopamineReceptors, #Psychopharmacology, #ADHD, #Serotonin, #Glutamate, #GABA, #Noradrenaline, #Cognition, #Activity, #Emotion, #Perception, #Sleep, #DopamineModulation, #Addiction, #RewardDeficitState, #CognitiveFlexibility, #Novelty, #Routines, #DopaminePathways, #MentalHealth, #Narcissism, #WellBeing
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Dr. Rege-would you consider making a video about “predicting violence in persons with mental illness”? 🎭
Great video suggestion!
Yes great video suggestion. I’ll add to the list !
@@PsychiatrySimplified My suggestion is to talk about the LEAP method, how to speak to someone who is psychotic. Dr. Rege I'm asking you to explain to me, how do you talk to someone who has lost their mind and is psychotic and believes things that are obviously wrong, how do you handle them?
As a person cumulating both the rigidity and perfectionnism associated with autism and the constant reward seeking state of ADHD, this resonates deeply. Finding the balance between 2 seemingly opposite traits is something I struggle tremendously with. Thank you for that video. I keep hoping to find the magic answer even though there isn't such a thing. I feel like a puppet.
I've done a few videos on ADHD treatment talking about this balance. I wonder if those may clarify a few things for you? Is the ADHD treated?
So grateful to have found your channel
Appreciate the feedback 🙏🏻
Dr. Rege, Thank you for another piece of jigsaw, in my understanding of the complex mechanisms of Dopamine, having SSRI induced EB and SD I was fully prepared to simply ask my GP for a dose of Dopamine, in my crude (at the time) understanding of depression I thought the simple release of Dopamine (the happy stuff) would be the answer. I now understand better, the real mechanisms and sequences of the processes involved, modulation is better than optimisation. I agree that the plethora of fixes and potions advertised for Dopamine is a dangerous thing, especially when there is no recognised scientific research to support them and no effective regulation.
Did you have physical symptoms
@@Truerealism747 Lethargy (lack of energy), constant tiredness and genital numbing
Dude your videos are great and awesome, exactly what we need, but i would recommend maybe a different microphone set up thats less agitating since people will unfortunately probably dismiss you with a reflexive reaction to the discordant sound. You say things bluntly and truthfully its precious. Everything else in the production is pretty great.
Thanks for the feedback. Could you be a bit more descriptive re the agitating part? Is it the entire video sound or something specific? I'm trying to understand to get it right. This video is filmed in a make shift ‘studio’ with no extra audio input so if i understand it better I can improve on it. I appreciate your feedback
@@PsychiatrySimplified hey sure, I just mean the vocal recording part after the into. It's like the ambience in the room is picked up on... So when you speak, or change the cadence/speed/vocal rigour it's reflected too much, and kind of results in an explosive sound element, it also 'clips' the high end I think, as certain vocal frequencies duplicate and overlap each other. It's just the vocal recording device which is probably incompatible with the spacey room you're in. I think a different or maybe directional mic that picks up more like a podcast would be better/solve the issue. They represents things with a pretty steady E.Q. It would then allow you to speak with any pace and all kinds of sounds recorded would be brought to a pretty close level. (And sound professional). It could also be the acoustics of the room itself if a mic swap test doesn't work. I'm not an expert on mics but I assume it's cheap and easy since almost all podcasts/explanatory videos have this quality and tone to them. I hope this helps answer things; your mixing and edits are good for makeshift, I think it's just the mic. I think that's all it is, and you could give it a test run and see if that's all it is, if it still seems too unclean , unpolished you could then attempt to experiment varying your speaking slightly. If you'd like I could even let you know next time you upload a video. Just message me or I can check your station, or you comment on any of my videos. -jonsat
Yeah it's through the whole video btw except perhaps a little of the intro(where you go through 6 points), but just the talking being recorded, there's a lot of high dynamics, which is like you're shouting sometimes. Some of the music is really well selected too, and some of it isn't, like the more repetitive ones at 2min30 and 25mins, but the one at 15 minutes is a great choice. Damn, great video again by the way.
Great presentation! Mind bogglingly complex. Modulating the different states of mind pharmacological must be a very delicate enterprise.
Thank you for your feedback 🙏🏻
So grateful for your content.🤯
The amount of time & variety of ADHD questions I have searched for over the years,
I would have expected UA-cams algorithm to have introduced me to you ages ago.🤔
superb explanation of very complex dopaminergic mechanisms
novelty, unexpected experiences, embracing change can enhance dopamine at D1 receptors
its the essence of life
thanks alot
may God blesss you
Thank you for your feedback 🙏🏻
hey Dr. Rege, are you planning on doing a similar video on glutamate (and receptors) and the proposed mecanisms of actions as an antidepressant, as an alternative to SSRIs? 🤔
also, do you know if any such compounds exited human trials and have been proven more effective than SSRI/SNRI for specific conditions?
Incredible video as all of your others. I cherish every video you post. Kudos.
Thank you. Appreciate the feedback 🙏🏼
Love it my upcoming book is in alignment with this ❤
I I think artha and karma are explained nicely. But the golal of these aspects is gaing kama. . And the peace that can be attained by controlling "kama" (which may have a nice translation of getting pleasure) and the perseverance to achieve the pleasure slowly convert (this seeking or/and achieving of pleasure) to the state that reduces the immense importance of the kama, which is vairgya. From here, one can choose either the path of self-realization (considered as eternal happiness or moksha ) or using "vairaagya" to get the continuum of peace in this "laugika jeevita" . If we can translate these aspects into neuroscitific language, it may give some idea of the total activity of a yogi or a gruhasta. I feel so. Since the peace, the consistency of all happiness has the balance of kama and vairagya for a laugikaperson.
Thanks for those insights. I touched on yoga / kama in the video on Ikigai. Have a listen to that as well. Your insights are very nice. Thanks
@@PsychiatrySimplified drive.google.com/drive/folders/1XtcxAMgYL1-R-nOF8z7xwJxcbHV0PmHc
Thank you, Dr. Rege. I am curious about excess dopamine and schizophrenia hypothesis I read about. I also read some other articles on scizophrenia and ph imbalance in the blood (1930) the blood was slightly acidic. Another, correlation or association was around half of patients with schizophrenia haf toxoplasmosis ghondi. Finally, I found another clue the calcium channel gateways in the cells. Clearly, there is something biochemical going on in this illness that is so complex. Can you discuss this? Elyn Saks, an attorney and Ph.D. wrote a book and did a Ted Talk about her turning point and diagnosis. I would love to hear about the scizophrenic illness and if it can go into remission etc.
Here I’ve written about the hypothesis. Yes it can go into remission and a certain percentage follows a relapsing remitting course - psychscenehub.com/psychinsights/the-dopamine-hypothesis-of-schizophrenia/
Learning this, nirvana came to mind. Thank you!
Pleasure
I mean the diagrams of the topics from 7:02 - 7:32 and 10:24 - 10:20 - 10:40 !!!
Did you see the recent paper that found normal peripheral norepinephrine and dopamine in CFS but reduced spinal fluid NE and DO metabolites? Was interesting.
Not surprised but this is known and inflammation reduces this. I’ve covered it in the videos on CFS / Long Covid . Consequences of neuroinflammation in general .
Dr Sanil.
When will we have new medications for Depression in Australia?
We have a lot in Australia - it’s just that not all on PBS. The treatment of depression in relation to successful outcomes is about using what we have appropriately which does make a difference. Depression consists of domains and deconstructing these domains and using medication / psychotherapy/ lifestyle changes etc to target these is necessary for optimal outcomes
Is this why nicotine patches help some with cfs etc as new evidence comes up as it helps dopamine
Yes that's right.
amazing, thanks a lot
Glad you liked it
Hi, what about unpredictable parents, does it decrease dopamine levels in children?
Like lashing out on a child and then being kind to them BCs feeling guilty. Is it considered an award?
You raise some very important points and it’s a theme for a further video. But in short yes it does result in a reward deficit state. I’ve covered this aspect more in the video on how Trauma ‘rewires’ the brain. Inconsistencies in parenting result in what is know as reward prediction processing duration which results in Dopamine dysregualtion. This can present with affective instability, mood swings, procrastination , self doubt and a range of ‘inconsistencies’ in self
@@PsychiatrySimplified thank you so much. Since ever watching your videos, some new areas of my mind have been unlocked. Thank you for sharing the professional content all for free.
Pleasure. Thanks for the feedback. 🙏🏻
Dr Sanil,
Is there a role for thyroid hormone therapy in depressive disorders?
psychscenehub.com/psychinsights/thyroid-gland-and-psychiatry/
Can you send me the diagram of the different neurotransmitters that ends in the dopamine production and if possible the inhibitory dopamanergic pathway (the VMPFC, DLPFC, and Insula-amygdala pathways if I am not wrong)!
Dr Rege off topic here sorry but wanted to ask you as I am trying to come off Tramadol 100mgs twice daily due to Australian Drs only being able to prescribe it once a month as of 2020 and you have to go to the GP for this in person. Is Cymbalta a good neuropathic pain killer? My Dr has put me on it at 30mgs going up to 60mgs in a month. Have you heard of people being able to come off Tramadol opioid type drugs by reducing and substituting it with Cymbalta for this sort of pain? Having to go to the Dr once a month every month for a 30 day supply of Tramadol is getting tiresome.
Can’t speak specially in your case but yes Duloxetine is effectively used for pain and can help. However in the transition duloxetine plus tramadol poses a risk of serotonin syndrome hence has to be done properly. Also Duloxetine pain benefits occur above 60 mg. Ps not advice
@@PsychiatrySimplified Thanks for the reply, my Dr has assessed the risk of serotonin syndrome and decided that the Duloxetine may benefit my neuropathic nerve pain and help me come off the opioids they kept me on for 31 years. What dose is considered effective to dull this kind of pain as I thought it was 60mgs?
It’s my understanding Dopamine also plays a role in thyroid function
Yes that’s right. dopamine stimulates the production of thyrotropin-releasing hormone (TRH) and inhibits the production of thyroid-stimulating hormone (TSH). The HPT axis also regulates dopamine release.
@@PsychiatrySimplifiedthis is why ADHD causes low thyroid
Music was annoying tbh
Apologies! for the whole video or certain parts?