Targeting Transcriptional Addiction In High risk Cancers

On Wednesday, April 6, 2022, Alex’s Lemonade Stand Foundation (ALSF) hosted a virtual childhood cancer lecture featuring Adam Durbin, MD/PhD. Dr. Durbin’s presentation discusses developments in the understand of cancer cell addiction to transcription, and new mechanisms to disrupt this process.
During this lecture, participants will:
Learn how functional genomics has led to the definition of transcriptional circuitries that drive malignant cell identity.
Understand how these circuitries can be perturbed in cancer cells to force malignant cells to acquire new cell states.
Learn about new preclinical technologies used to target transcription.
Adam Durbin, MD, PhD is a member of the faculty at St. Jude Children’s Research Hospital in the Division of Molecular Oncology, Department of Oncology and the Developmental Biology and Solid Tumor Program. His team works to understand how transcriptional regulatory circuitries establish malignant cell identity, and how these circuitries can be perturbed for clinical benefit using conventional and novel small molecules.
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