amazing compilation as always thanks for your extensive work doctor it's highly appreciated from us alopecia suffferers that like to deep dive into research studies. if you don't mind i have a question regarding ffa . i know oral dutasteride is in the gold standard list but what's your take on mesotherapy with dut? and also mesotherapy with minoxidil? ( since OM is supposed to be hlefpull in ffa and also lpp ) i know there are no medical studies regarding those 2 but do you think it could help? thanks and happy new year
Thank you for all your informative videos. I’ve always been a bit confused when choosing between Finesteride and Dutasteride and which is superior in treating AGA. The study you spoke of regarding FPHL and what is most affective listed Finesteride 5mg as the most affective. How does Dutasteride at 0.5mg compare to the dosage of Finasteride 5mg? Should I be increasing my Dutasteride dosage or possibly changing to Finasteride for optimal improvement. I am not of child bearing age. I’ve been on Dutasteride for several years with no improvement.
We don’t know how dutasteride compares or it would most certainly have been included in this study. They are probably somewhat similar when comparing finasteride 5 mg once daily and dutasteride 0.5 mg once daily. But good studies are needed. I don’t know enough about your story to say if you should switch or not. A doctor who knows your story and knows how the dutasteride has been working can help solve this. If you are taking suboptimal doses of dutasteride then increasing to optimal doses like 0.5 mg daily would be reasonable for many patients before jumping to finasteride. I doubt that a switch is going to make a huge difference but yes, could make some. Bringing on board another mechanism of treating the hair loss probably makes more sense for most (assuming the dutasteride dose is optimal). Minoxidil, laser and other antiandrogens with different mechanisms (spironolactone, bicalutamide) can all be carefully and thoroughly reviewed with your doctor. All in all, we don’t have great data comparing finasteride and dutasteride yet. While they may be slightly different, it’s unlikely a huge difference for most. Therefore, if one is on an optimal dose (like 0.5 mg daily) and still not getting results, the best plan probably involves looking into adding other treatments rather than time spent on deciding whether to switch to finasteride. If one is not using a proper dose of dutasteride, it may be worth moving forward with a good dose and deciding on next steps in 6-9 months. One must always make sure that there are no other hair loss issues present that themselves require treatment (scarring alopecia, telogen effluvium, etc).
Hello Dr. Donovan I'm very interested in featuring you on my channel for an interview, where we can discuss questions from my subscribers. Your website and services have garnered much admiration from us. Additionally, I have a personal inquiry: How is CCCA manifested, and what are the identifiable biological markers in a scalp biopsy? Are general inflammatory signs present, and how do these differ from other inflammatory skin conditions? I concur with your approach that early and aggressive action leads to more favorable outcomes. In my view, factors like DHT and the Androgen receptor's impact on macrophages, as well as their effects on the WNT pathway following DHT-AR complex transcription, are pivotal in suppressing hair follicle growth, suggesting AGA is akin to other skin diseases. I look forward to the possibility of discussing these topics further with you.
CCCA affects many black women and sometimes black males too. Patients present with central hair loss and there may or may not be symptoms. The area expands over time without treatment . The biopsy findings resemble lichen planopilaris very very closely if not perfectly in some cases. There is some eccentric thinning of the root sheath and premature separation of the IRS but these are not entirely specific. There may be redness clinically but there does not have to be. The biopsy may highlight mild to moderate inflammation but the inflammation is often much less than typical classical LPP. Be sure to read more on our website donovanmedical.com/hair-blog/ccca-2. As for interviews, simply contact my office and they can arrange. The website donovanmedical.com takes you to them! Happy New Year.
Tthank you Dr for your efforts. I am also Dr i suffer from TE for 10 months it is after covid 19 infection. Doctors told me that my hair will come back but i m not sure since it seems to be fibrosis it is diffuse it starts on occipital part then all the scalp . Mu temples start to look like patients with fibrosis alopecia what can i do to stop the progress. I have strong pain on my scalp with sensation of burn and when i feel this why i loose more hair then other days please answer me i visited 7 doctors all they said to me is stress, covid and maybe AGA will start to appear but i m sure it is different my middle hair line is not large my hair is thick but i loose it without any regrowth and the scalp is so white.
Love all your due diligence, efforts, and knowledge. Much appreciated, Doc! 🙏
thank you!
amazing compilation as always thanks for your extensive work doctor it's highly appreciated from us alopecia suffferers that like to deep dive into research studies. if you don't mind i have a question regarding ffa . i know oral dutasteride is in the gold standard list but what's your take on mesotherapy with dut? and also mesotherapy with minoxidil? ( since OM is supposed to be hlefpull in ffa and also lpp ) i know there are no medical studies regarding those 2 but do you think it could help? thanks and happy new year
Thank you for all your informative videos. I’ve always been a bit confused when choosing between Finesteride and Dutasteride and which is superior in treating AGA. The study you spoke of regarding FPHL and what is most affective listed Finesteride 5mg as the most affective. How does Dutasteride at 0.5mg compare to the dosage of Finasteride 5mg? Should I be increasing my Dutasteride dosage or possibly changing to Finasteride for optimal improvement. I am not of child bearing age. I’ve been on Dutasteride for several years with no improvement.
We don’t know how dutasteride compares or it would most certainly have been included in this study. They are probably somewhat similar when comparing finasteride 5 mg once daily and dutasteride 0.5 mg once daily. But good studies are needed. I don’t know enough about your story to say if you should switch or not. A doctor who knows your story and knows how the dutasteride has been working can help solve this. If you are taking suboptimal doses of dutasteride then increasing to optimal doses like 0.5 mg daily would be reasonable for many patients before jumping to finasteride. I doubt that a switch is going to make a huge difference but yes, could make some. Bringing on board another mechanism of treating the hair loss probably makes more sense for most (assuming the dutasteride dose is optimal). Minoxidil, laser and other antiandrogens with different mechanisms (spironolactone, bicalutamide) can all be carefully and thoroughly reviewed with your doctor. All in all, we don’t have great data comparing finasteride and dutasteride yet. While they may be slightly different, it’s unlikely a huge difference for most. Therefore, if one is on an optimal dose (like 0.5 mg daily) and still not getting results, the best plan probably involves looking into adding other treatments rather than time spent on deciding whether to switch to finasteride. If one is not using a proper dose of dutasteride, it may be worth moving forward with a good dose and deciding on next steps in 6-9 months. One must always make sure that there are no other hair loss issues present that themselves require treatment (scarring alopecia, telogen effluvium, etc).
Hello Dr. Donovan
I'm very interested in featuring you on my channel for an interview, where we can discuss questions from my subscribers. Your website and services have garnered much admiration from us.
Additionally, I have a personal inquiry: How is CCCA manifested, and what are the identifiable biological markers in a scalp biopsy? Are general inflammatory signs present, and how do these differ from other inflammatory skin conditions?
I concur with your approach that early and aggressive action leads to more favorable outcomes. In my view, factors like DHT and the Androgen receptor's impact on macrophages, as well as their effects on the WNT pathway following DHT-AR complex transcription, are pivotal in suppressing hair follicle growth, suggesting AGA is akin to other skin diseases.
I look forward to the possibility of discussing these topics further with you.
CCCA affects many black women and sometimes black males too. Patients present with central hair loss and there may or may not be symptoms. The area expands over time without treatment . The biopsy findings resemble lichen planopilaris very very closely if not perfectly in some cases. There is some eccentric thinning of the root sheath and premature separation of the IRS but these are not entirely specific. There may be redness clinically but there does not have to be. The biopsy may highlight mild to moderate inflammation but the inflammation is often much less than typical classical LPP. Be sure to read more on our website donovanmedical.com/hair-blog/ccca-2. As for interviews, simply contact my office and they can arrange. The website donovanmedical.com takes you to them! Happy New Year.
@@donovanmedical9780 thank you for getting back to me Doctor! I'll be sure to set that up.
Tthank you Dr for your efforts. I am also Dr i suffer from TE for 10 months it is after covid 19 infection. Doctors told me that my hair will come back but i m not sure since it seems to be fibrosis it is diffuse it starts on occipital part then all the scalp . Mu temples start to look like patients with fibrosis alopecia what can i do to stop the progress. I have strong pain on my scalp with sensation of burn and when i feel this why i loose more hair then other days please answer me i visited 7 doctors all they said to me is stress, covid and maybe AGA will start to appear but i m sure it is different my middle hair line is not large my hair is thick but i loose it without any regrowth and the scalp is so white.