Electrophilic Aromatic Substitution Reactions Made Easy!
Вставка
- Опубліковано 7 тра 2018
- This organic chemistry video tutorial provides a basic introduction into electrophilic aromatic substitution reactions.
Here is a list of reactions covered in this video:
1. Friedel Crafts Alkylation of Benzene
2. Bromination of Ethylbenzene
3. Aromatic Nitration of Benzene followed by Bromination of Nitrobenzene
4. Polyalkylation Using Friedel Crafts Alkyation
5. Chlorination of a Disubstituted Benzene Derivative
6. Sulfonation of para-methylphenol.
7. Steric Effects and Directing Effects of Disubstituted Benzene Derivatives
8. Friedel Crafts Aklyation Reaction and Strongly Deactivating Groups
9. Synthesis of Benzoic Acid From Benzene
10. Side Chain Oxidation Using Chromic Acid
11. Synthesis of Aniline From Benzene
12. Synthesis of Benzaldehyde From Benzene Using The Gatterman Koch Reaction
13. Synthesis of Propyl Benzene Using the Friedel Crafts Acylation Reaction Followed by the Clemmensen Reduction Reaction.
14. Synthesis of Toluene From Bromobenzene Using an Organocuprate Reagent / Gilman Reagent
15. Synthesis of meta-iodobenzenesulfonic acid
16. Synthesis of para-nitrobenzoic acid
17. Synthesis of meta-chloroaniline
18. Synthesis of para-nitroaniline
19. Protecting amine groups with acid chlorides by amide formation
20. Blocking Groups
21. Application of Desulfonation Reactions
22. Synthesis of a Trisubstituted Benzene Derivative
Subscribe:
/ @theorganicchemistrytutor
Access to Premium Videos:
/ mathsciencetutor
/ mathsciencetutoring
New Organic Chemistry Playlist
• Organic Chemistry - Ho...
Final Exams and Video Playlists: www.video-tutor.net/
Id just like to thank you for all the videos you put out. It has helped me get a 95/100 on my Ochem Exam and I am so beyond greatful that you are here to teach. Keep doing what you are doing because you're making positive changes in students lives. I was in a negative mindset due to my first exam score being soso low. But these videos gave me hope and it really did change my thoughts and how I felt. I no longer feel like a failure and these videos are the reason for that. Keep fighting through everyone!! I am taking my final exam today :)
whaddaheq, howww??????
Please help me
Yo that is incredible. Congratsssss
Same here, Big thanks
Congratulations. 🎉.
I thought I understand organic chemistry until I took my exams. Haha I fooled myself big time
SORRY
I can relate
This was me today 😩😭😭
@@utibeimaevans629 did you use this video
lol relateeee
i had 2 week to catch up from school, but this one hour video covered a week and half of that work.. you the GOAT
How has school been going?
This man is the only reason I am doing good in Organic Chemistry 2. Thank you so so much!
This has gotta be one of your best videos, thank u for explaining every scenario possible
I learned more in the first minute than I ever learned doing two weeks worth of this stuff in lecture. Thank you!!!
Thank you so much for giving Synthesis a very intuitive perspective. I dont have a major in Chemistry, but from this video I have got a very solid orientation of how to think about and solve synthesis problems.
this is a great freaking video to watch/review what you learned after you spend a good chunk of time going over the theory behind in your textbook. good way to synthesize everything you learned.
You are a so phantastic teacher!!! God bless you! I‘am looking every video of you and write it down! It’s so helpful!!! I can’t say enough: thank you soooo much!!! 🙏🙏🙏
You have been helping me for years. Thank you so much for all of the good times!
This was exactly what i was searching for! Thanks
thank you mr ochem tutor you saved my life i love you youre the best :D
this literally is one of the best videos I've ever watched
I think I’ve found the best organic chemistry tutor so far for real ♥️
do you recommend to me this canal to follow,
Thanks so much, you explain things so well!
Best teacher ever.
Honestly I wasn’t doing great in organic until I started skipping class. I’m great at pattern recognition (need a ton more data than is provided in class) and learning but horrible in the class setting teachers always talk to slow and don’t challenge me enough to be interested. Here I can just play everything 1.5- 2x speed pause and solve the problem and easily and quickly figure out where I messed up. Normal pace in class kills me and I can not help but zone out. But i can easily absorb everything discussed in class in 20 min by myself. Which is probably the amount of time I actually pay attention in normal class. I can’t remember anything but if I just throw myself into the information and expose myself to as many situations and problems as possible it clicks and all of a sudden and I see everything as images and videos in my head. It makes learning feel like a drug and you get high on the excitement of everything magically fitting together. Learning in class feels like hell the education system has a way of sucking the excitement of even the most interesting of things.
Same here! It sucked at first, and class was such a drag. But he makes it 10x better. Once you understand the stuff its so much fun.
Omg, this is sooo helpful! Thank you very much for your hard work! Your videos helped me a lot with my studies! :)
How have your studies been going since then?
This video saved me. Love your channel
I love you man thank you for pulling through so consistently
I swear my professor probably watches your videos. This is precisely what she said what going to be on our test. And you even should the mechanism (Friedel - crafts with carbonation rearrangement) we need to know. I find this too funny. Hopefully I get a 100%
Best teacher for jee advanced
Your videos are really very helpful. Thanks for sharing
I must say your teaching is amazing ❤
Thank you so much for saving me in this semester!
You Sir have just saved my life
Awesome work as always.
EAS reactions made easy? More like “Everything made pleasing!” I really like your nice handwriting and clear demonstration on the board. Thank you again so much for making all these videos!
Thank you SO much kind sir !
ily sm. thank youuuu for this video, i appreciate it with all my heart :3
thank you sir it is very helpful
This video really help me to study..Thank you!!!☺️
How have your classes been going?
Thnq so much sir...it is really helpful
You deserve a thumb's up. I mean the cold drink😉
You're the best
Great video,perfect explanations,God richly bless you
Hey, how does Br2 not attach to ortho and meta but ortho and para, do you mind explaining please ?
@@drana2626 I can explain, but do you still wanna know lol
@@DarkGourmandsure
it helps me a lott, english is not my motherlanguage but i can understand everything so well!! thankyou sir 🤩
You are genious sir
Thank you sir
非常感謝您的教學
God bless you sir,
Sir which tool are you using in making is videos that make it so unique?
Thank you so much
You are a legend
You’re amazing
Best video .. ♡
Wow dude you rock
I love you o chem tutor
Thanks a lot
Hey, even with some steric effects, wouldnt the ortho position win out rather than the para because there are double the amounts of ortho positions (2) rather than one para position?
Stability matters more
@49:40min the protected -NH2 forming amide group, is it still possible to be protonated under acid conditions (HNO3/H2SO4) to deactivate the reactivity of the benzene ring?
thank you!!!!!!
Thank youuu😫
🎉 happy new year sir
Thank you so much for all the practice examples and the detailed explanations!!!!! For the reaction at 31:41, can we perform Friedel Craft Acylation reaction to get the product in one step?
Thank you
At 22:55 why is the benzene with the more substituted carbon the major product? Does benzene prefer more more substituted rearrangements in general?
In prepared para-nitro aniline if l started with (Br) then added (No2) in para position then add (NaNH2) to convert (Br) with (NH2)
this situation doesn't happened ,does it ?
i have a question why is it a mixture of these two molecules in 2:29 wouldn't the para position be favoured due to steric collision with the ortho position?
I think at around 5:51 when he said the ethyl wants to direct the chlorine atom in the ortho position he meant meta because he circles position 3.
omg thank u so much
Thank yooooou 😭
quick question: how come in the 1st example there isn't a hydride shift to stabilize 1ary ch3ch2+ into a secondary?
you still get a primary carbocation, so no need to do that.
nice sir
two questions,
1. at 43:26 I realized that he's using potassium permanganate in heat and basic conditions to oxidize to a carboxylic acid, but shouldn't it be acidic so you can go straight to the acid, or use water? I was a little confused on that but I get the rest.
2. can you use other things for iodination because I thought it had to I2/CuCl2, does using nitric acid also work?
sorry for the weird question, thanks so much for the help
i have a question, how can you identify if its a friedel crafts? do we look at both the starting material and reagents and if they are both "meta? as in have a positive charge on the atom that is both attached to the benzene and the reagent?
The AlCl3 indicates its a friedel craft alkylation
At 2:30, the para position is actually the major product because there is less steric hindrance
I was searching for your comment like I just wanted to confirm that I think the same way as someone else
56:23 would it even be possible to add a terbutyl group to this ring?
Considering that the Friedel Craft's reaction can't occur because the ring is being deactivated by two EWGs, and the other reaction that leads to an alkylation of the benzene ring shown in the video is the one where you add a bromide and then you react this product with (R)2CuLi, but here you already have a bromide on the ring, so you would have many possible side products here(although the product where the Terbutyl group is in the Para position with respect to the nitro group would be the major product of this hypothetical bromation+alkylation reaction route if it is even possible).
So i don't think this synthetic route shown in the video is even possible, and if it is, then it's not entirely accurate.
But given that this clearly was not the best synthetic route to get to the intended product anyways, it doesn't really matter if it's not 100% correct.
i love sir
you are delicious teacher 100% please do not die as aliving thing you should live for ever .
why does bromine behave as electrophile because it readily forms br- ion ?
Ochem tutor for president
Why did you choose to do a secondary carbocation instead of a tertiary with the butane carbocation rearrangement?
When we use friedel craft alkylation in the synthesis questions, wont polyalkylations occur?
it depends on the quantities of the benzene ring and the reagent
@45:00 wouldn't NO2 deactive the ring? How would you be able to add a halogen on it?
RevaN only fiedel craft’s reaction is hindered by that. Meaning with a nitrate group you can’t do alkylation or acylation
@@basilkhan1998 Thanks!
at minute 45, how does the reaction proceed? i thought nitrobenzene was too deactivating to undergo friedle crafts alkylation
how to know the types of reagents to use, when synthesizing?
you are the real goat on god
44:45 It should been Cl2 with FeCl3 Right?
for the example at 31 mins why cant we do friedel crafts acylation?
How many are watching this in 2021.....
This are lot of theories than I thought
Thank you man after drinking some smooth tequila this shit has gain me wisdom to dominate my assignments
6:42 ok why did we consider NO2 isn’t it a EWG??
i'm literally gonna go crazy if i draw one more hexagon lol
u you cant use freidel craft to add a halogen to nitrobenzene. I see u used it in synthesis where u needed to use nitrbenzene to substitute a halogen at the meta carbon b4 reducing nitro group to NH2
how are you suppose to remember all the reagents. Lol it seems hard!!
Hi Hayley
The minor producccccc
20:05 isn't carboxylate grp meta directing??
carboxyl is meta yeah, idk about the carboxylate though
i would die for you
ok lion queen
Name of réaction pleas
1,5x Speed.
9
23:30
نزل الفديوهات مع الترجمه الى عربي وسوف ندعمك
30:30
i don't understand at all😭😭😭😭😭
First