Intro to Electrophilic Aromatic Substitution: Crash Course Organic Chemistry #37

We’ve talked about benzene a bit already in this series, but did you know that benzene rings are present in all kinds of familiar substances? The styrofoam packaging that comes with new appliances, some pharmaceuticals, pesticides, and even some explosives contain benzene. In this episode of Crash Course Organic Chemistry, we’ll see how we can use electrophilic aromatic substitution to attach stuff to benzene rings like halogens, carbons, and more!
Episode Sources:
Rocke, A.J., 1985. Hypothesis and experiment in the early development of Kekule's benzene theory. Annals of Science, 42(4), pp.355-381.
Martín, N. and Scott, L.T., 2015. Challenges in aromaticity: 150 years after Kekulé's benzene. Chemical Society Reviews, 44(18), pp.6397-6400.
Stuttgart, G., 2018. Charles Friedel (1832-1899) And James Mason Crafts (1839-1917): The Friedel-Crafts Alkylation And Acylation Reactions. [online] Thieme.de. Available at: www.thieme.de/statics/bilder/...
Series Sources:
Brown, W. H., Iverson, B. L., Ansyln, E. V., Foote, C., Organic Chemistry; 8th ed.; Cengage Learning, Boston, 2018.
Bruice, P. Y., Organic Chemistry, 7th ed.; Pearson Education, Inc., United States, 2014.
Clayden, J., Greeves, N., Warren., S., Organic Chemistry, 2nd ed.; Oxford University Press, New York, 2012.
Jones Jr., M.; Fleming, S. A., Organic Chemistry, 5th ed.; W. W. Norton & Company, New York, 2014.
Klein., D., Organic Chemistry; 1st ed.; John Wiley & Sons, United States, 2012.
Louden M., Organic Chemistry; 5th ed.; Roberts and Company Publishers, Colorado, 2009.
McMurry, J., Organic Chemistry, 9th ed.; Cengage Learning, Boston, 2016.
Smith, J. G., Organic chemistry; 6th ed.; McGraw-Hill Education, New York, 2020.
Wade., L. G., Organic Chemistry; 8th ed.; Pearson Education, Inc., United States, 2013.
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[@Don-sk]

Ahhhhh the joy of watching this after completing my Pharmacy degree. - Some advice, whatever’s stressing you out today, tomorrow will be nothing. Take it easy and learn to enjoy every bit of work, bcos you’ll never live the same day

[@pvcmoviestudio8281]

It was an astonishing class to me. Electrophilic substitution reaction was unclear to me a long time. After this logical simulation I just escaped from a biggest obstacle. Thanks Crash Course.

[@mich8050]

We're now 37 videos deep in this Organic chemistry course and we are still on intros to things!
I was slightly out of my depth before this and given there are still intros to get to grips with there is going to come a point where I drown

[@carsonclayson7063]

I loved the Rotom cameo 😂

[@flamystr]

Im from Russia, and i love this Chanel, my teacher showed this video on lesson. Thanks for that video!

[@mangaluver1231]

Oh this is perfect we just started learning about this yesterday in my ochem 2 class!

[@Stherko20]

0:11 is that Prof. Juniper from Pokemon? Nice :)

[@user-bp8yg3ko1r]

Nice content!

[@jordanjames5479]

You guy's are the best!!!,,,😆😆

[@CommanderCodey]

Lmao you can get so confused very easily when it comes to chemistry. I had to rewind a couple times to make sure I understood.

[@unclebobo6030]

Hi how's it going watching from Broomfield Colorado

[@madboycal7859]

I don’t think I’ve ever been this early. 😳

[@large_hadron_colander8301]

I love the rotom heat in the thumbnail!

[@Seth_rs]

Im pretty sure the microwave in the thumbnail is a reference to rotom from pokemon

[@LouieFromPikmin2]

Rotom

[@garethdean6382]

The question is, with a sufficiently powerful acid, could we isolate some of these carbocation intermediates?

[@MarMar_Stacks]

Featuring Rotom-Heat

[@jubran7469]

A rotom? :O

[@AssessTheThreat]

I only clicked for the Rotom Heat in the thumbnail.

[@selrahc1322]

Only reason i clicked was for that rotom reference.⚡👻🔥

[@KingJH0510]

I like the pokemon references

[@Meowcowz]

Where was this when I had to endure ochem 😭

[@mollie4563]

Early

[@jonathansinanan1855]

First 👀

[@ArawnOfAnnwn]

FIRST!!