Second Gas Effect and Concentration Effect

The Second Gas Effect and the Concentration Effect, while not so clinically significant are still super important from a physiologic understanding standpoint. Here we examine what each of them are in simple terms and explain how the two are related, as always, using my crude drawings. Enjoy!
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[@danaattieh8290]

Very nice explanation and diagram. However, i have to point out that there might have been a mix up in the concept of the concept of the concentration effect. The concentration effect refers to the phenomenon where the nitrous oxide increases its own concentration, not the other gases.
Its effect of increasing the concentration of other gases is called the second gas effect

[@xDomglmao]

Thank you! Apart from that vid is fine?

[@brtnik96]

yeah, that's what i was thinking about... why does the decreased partial pressure of N2O does't increase amount of N2O coming in the alveoli. So do i understand it correctly, that that's the principle of concentration effect? :) thanks for your answer and thanks for your videos, CBF10 :)

[@tijanitunkara2553]

From my understanding is that since N2O is 34x soluble in blood than N2( highest gas in the alveolar), the rate N2O move into the blood is 34x greater than N2 moving into the alveolar, this causes the alveolar to shrink and that automatically increases the PP of the 2nd gas in the alveolar.. this automatically increases the Pbr!!

[@oreskoul]

well , simply explained . thank you Doc.

[@leoyanes126]

Excellent video and explanation. finally I get the concept. anesthesia student here. big fan.

[@user-yz7dg2qy4m]

It's really helpful!! Thanks for explaining it so clearly.
You really help a university student
who is preparing for her mid-term exam😄

[@CountBackwardsFrom10]

Thank you so, so much for your kind comments! my only request is that if you like the content, to subscribe and pass it on to anyone you think it may help! :D

[@ramcharu5660]

Thanks for the video, I'm a begginer in anesthesia. I watched the video entirely to understamd what is second gas effect, but one question meke me to be confused (this may be due to my simple knowledge on lung phisiology, I don't know exactly).
The question is that: When N2O is entering the blood capilaries around the alveoli, why the replaced alveolar gas will be sevoflurane? Why it is not N2O itself?

[@karamal-naqar477]

Exactly, why wouldn't the vacuum left behind just be refilled with both (SEVO and NO2). My second question is (if the whole point of co-adminestering NO2 with SEVO is to increase the alveolar concentration of SEVO, then why not just give more SEVO)

[@CanopiedSun]

Because n20 diffuses faster, and due to poor solubility it moves to brain faster, also we don’t give more anaesthetic because that’s the point.. we want to give as little anaesthetic as possible that’d still do the job.

[@aaronmatulevich454]

Learned a lot, thank you for video

[@JeffreyQProductions]

Thanks from an SRNA!

[@CountBackwardsFrom10]

Jeffrey, thank you so, so much for your kind comments! my only request is that if you like the content, to subscribe and pass it on to anyone you think it may help! :D

[@flaminmongrel6955]

physio student here, thanks for the explanation.

[@dr.anupkumarsingh3108]

Thank you so much
Tomorrow is my exam and this question is very important .....
Dr. Anup Kumar Singh

[@hulyaneben3369]

Thank you, Doc!

[@scidro1115]

Thank you sir

[@themusicdoctor9557]

Now I get it, Thx 😇

[@CountBackwardsFrom10]

Thank you so, so much for watching! I hope they help! Please pass them on to anyone else you think may find useful!

[@khushnandini3400]

Does the void created would not create h gradient for nitrous oxide from the vaporizer to alveoli

[@hafizyusaryahya9556]

what's the clinical usage of all of these things? it's hard for me to grasp me the concept unless i got something practical that i can later use it

[@amitkumar.7848]

Less and more economical use of our inhalation agents, by using less conc. Its concentration can be increased in alveoli by 2nd gas effect

[@revolutionaryminds1491]

Thank you so much 😍

[@DanielVieiraGuitar]

If sevoflurane has a higher blood/gas partition coefficient than N2O, hence being more soluble in blood than N20, why does the 2nd gas effects occurr because of N20 and not because of sevoflurane?

[@syedrameezhassan1805]

May be because of the overall fraction of the anesthesia gas mixture, sevo is just given in 1-2% usually, while N20 given up to 70%.

[@youtubemimoo2429]

Thanks sir .....really appreciated ❤️👍

[@omuryldz2469]

Hello, does nitrous oxide given under general anesthesia and by intubation cause an increase in volume in the uterus of female patients? Does it cause bloating and accumulation like intestines in the uterus?

[@iromeko2389]

Very helpful

[@himaragapriya2099]

Thank you so much..

[@viperpm]

Stoelting's Pharmacology book sucks compared to this! Cheers sir!

[@nareshchandramohan.a4555]

👍

[@scidro1115]

Basically it doesn't matter

[@elias-rn6mx]

Confused

[@abdulkadirahmed4985]

not good explanation....i dont get u

[@KhaN11594]

Maybe u were busy with ur children 😅
Watch it again

[@-VK-NorleenPandhiLepcha]

🙏🫂