Reversing Heart Disease, Creatine on Kidney Health, 5 Life Extending Habits, and More
Вставка
- Опубліковано 12 лип 2024
- JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]
Join the Physionic Insiders [Standard Tier]: bit.ly/PhysionicInsiders2
Join the Physionic Insiders [Pro Tier]: bit.ly/PhysionicInsidersPro
Standard Tier: Access to the Premium Video Library, Full Study Analyses (+ Summaries), Insider Podcast, , Research Reviews, and More
Pro Tier: All benefits of the Standard Tier + Live Sessions with Me, Consulting Lite, and More
HEALTH AUTONOMY [COURSE]
Learn to Analyze & Apply Studies for Yourself: bit.ly/healthautonomy
JOIN THE COMMUNITY
Join my Community [It’s Free!]: bit.ly/PhysionicCommunity2
EMAIL LIST
One Weekly Email of Value: bit.ly/2AXIzK6
HIRE ME FOR CONSULTING:
Consulting: bit.ly/3dmUl2H
DONATIONS FOR A SCIENCE BASED CAUSE
Patreon: bit.ly/PhysionicPatreon
OTHER SOCIAL MEDIA
Instagram: bit.ly/2OBFe7i
Created with Biorender
0:00 - Introduction
7:29 - Urolithin A Supplementation
20:44 - Gaining Muscle and Strength as a 90 Year Old
38:05 - Obesity increases Autophagy
1:10:45 - GLP1A Drugs on Health and Weight Loss
1:35:56 - 5 Factors that Extend Life
1:53:15 - Creatine on Kidney Health
2:06:52 - Reversing Atherosclerosis
2:48:22 - Personal Fat Threshold
3:06:11 - Lp(a) and Heart Disease
3:39:12 - Diet Breaks for Fat Loss
3:46:30 - Lion's Mane and Cognition
3:55:52 - Weight loss linked to Heart Disease
4:09:55 - Nattokinase Supplementation for Heart Disease
4:24:51 - Plastic in our Arteries
4:33:05 - Cancer steals Mitochondria
4:57:35 - Housekeeping Updates
*******CRITIQUES, RULES, AND NOTES*******
Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:
The information provided in this study analysis is limited to the subject and outcomes detailed in the study analyzed [For example: “Consuming sugar (subject) raises insulin (outcome).”] and is not meant to be an all-encompassing education on every health outcome of the subject (unless otherwise stated). I welcome all respectful critique of the study as I may have missed a key detail that you may catch; if that is the case, I will make an ‘Amendment’ to the video and credit you (thank you for making science knowledge better!). Also be aware that I receive hundreds of UA-cam comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, UA-cam auto-deletes links, so I do not see most comments with links attached.
RULES:
If your comment is rude, you will be banned without warning.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, your comment will be ignored.
If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it.
Please use the following link to submit your critique: bit.ly/PhysionicCritique
Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.
![Taurine: Aging Backwards? [Study 193 Analysis]](http://i.ytimg.com/vi/PNJpM0ac0GU/mqdefault.jpg)
Last episode was only 4 hours, and that’s just unacceptable. How are you going to sleep for only 4 hours?
So, this episode is now LONGER and MORE BORING (YOU’RE WELCOME!) - still not enough for a full night’s sleep, but we’ll get there (need to get a larger storage). Maybe staple this episode with the last for now. I apologize for how brief this episode is.
Ha ha 😄 Seriously though, thank you so much for sharing your knowledge and intelligence!
Funny! You keep my brain synaptic cells firing💄
Im going to listen while cleaning and tidying the house.
Works out fine untill I vacuum the floor
I want to know the name
I want to live as long as I can. I would like to do.
George Davis
Bro. 5 hours. You’re a machine. Gonna have to make time for this one
We are spoiled fs
a piece of science machinery 😆
Bro seriously did a 5 hr talk on health. I'm impressed. Been a listener for a while but just subscribed!
Thanks, Dude!
A 5 hour drop from physionic?! Christmas has come early!
Yes!
"If you make a claim, you should probably show evidence for it". Completely agreed. A bunch of people, especially on reddit, really don't like it, because they'd actually have to do the work to find proof for the claims of their favorite influencer, and these very commonly don't share any evidence whatsoever. People shouldn't be going around making claims without responsibility, and in my opinion, the bigger the claim, the higher the necessity for providing evidence.
Five hours and 3 minutes ? I'm an old man, I'll have to pee three times.
I'll second that! Ah, to be 75 again.
🤣🤣🤣
mmmmmm
😂
I so appreciate your commitment to deliver evidence-based info that covers all the evidence, not just what supports an agenda or confirmation bias. Thank you for demonstrating what an “interest in science” is supposed to mean.
Saving this for a 10 hr drive… gives me something to look forward to.
Fuck yeah, bro, that's how you do it 😅
I finally finished this episode. TBH, this format is my favorite!
I subscribed to your channel after finding your video on the metabolic theory of cancer, and I've been a regular viewer ever since. I'm still waiting for a follow-up, and I really like the idea of a two-part interview with Dr. Seyfried. For me, this topic is the one I most want to find out the answer to: cancer is the second leading cause of death worldwide, so stimulating a major breakthrough in this area could save hundreds of millions of lives.
Having a scientific background, I've tried to read studies on the topic, but I just don't have enough time. I'm hoping that one day you will cover the topic more thoroughly, one way or another.
Wow. Five hours! What a gift. Thank you!
This is fantastic!! A refresher on so many important items that we all should be considering. I love your work And as a 74-year young human I try and apply all of your fantastic sharings. Thank you very much for this. It's a great day for gardening and this will make it even more exciting 💕🫂🌻
Absolutely epic loved this
Excited to watch this one!
Great info! Many thanks for sharing bro
Legend brother. Thank you for this!!!
You're a legend. Love this. And thank you for being able to do all that stuff 🤯
All great stuff Nick, you are a deep well of valuable stuff
so smart,I'll be glad to make time to listen. Thank you.
You’re amazing! Thank you for all your knowledge 🙏🏼🙌🏼💕
Critical topics for sure. I will spend the weekend digesting this. Thanks so much.
I skipped to what I want to hear and still listen to most of the podcast. You did a great job. Ty.
By far the best channel on UA-cam! Thanks Physionic. 😊
Good day, everybody 🎉
I am going to listen til the end 😂
Keep them coming, anything about health on the cellular and molecular level 👍
5 hours! I'm finding out how you sound on 1.25-1.5 speed right now! Lol
It’s pretty funny, it tones down his sexiness a bit on the higher speeds, which actually improves my focus. 😂
1.5x speed makes him seem a bit neurotic but his voice is still lovely. Lol
I’m using 1.75x speed now and I think this might be a good speed at which to exercise my brain. Lol
Excellent video. Thank you
Thanks for all the information
Great information ❤ thank you 🙏🏼
You truly are a wonderful teacher. Thank you for your WORK!
Five hours, you’re killing me, I don’t know how you do this, it’s gonna take me days to get through.
Thank you once again for your heroic effort. I, for one will likely live that much longer because of your dedication and ability to impart such important information.
Firstly thank you so much for giving this ready to grasp information and you are doing an excellent job.It just does not make any difference if it is 5 hours or more.I encourage you to keep up the good work.
I Imagine how long have you studied for this podcast appreciate your work thank you
I have to say I really enjoy your videos You're very helpful for humans and you are extremely brilliant I love the way you explain the details sometimes using words that I don't normally hear and explaining what you mean by those words very good thank you
Hi Nick, Thank you so much for all your time, efforts, and brilliance to do these extended podcasts!!!! I watch all of them and use your insights daily to work for great health and quality of life. I do want to live to be a healthy 100+, 27 more years to live and love.
You explain very well , your level to do so is appreciated.
I’m sure you are very busy researching so many avenues of health, but should you ever come across info on Oxalates and macular degeneration I would like to hear your take on them.
Thanks again.
re Urolithin A, I am a 66yo male and since adding pommegranates to my breakfast I have reached a VO2 of 54ml/kg/min which at 99.5% for my peers. I also take Ubiquinol, PQQ, niacin (NA), however I associate the addition of the fruit to the rise in VO2. I am a 5 day/week runner, my RHR is 45 while my max HR is 193.
I should add that I also take apigenin
@@petervafeades4095 Yes I juice pomegranates with a head of parsley and it is astonishing! People think I'm crazy but who cares!
193 max HR is impressive at your age!
@@pedro.almeidaextremely!
Holee! 193 max? Impressive! I am 72 but my internist (on board to figure out occasional inappropriate sinus tachycardia) says my biological age is early 50s. I just can’t begin to imagine having such a low RHR - unless you have brachycardia - let alone a mix of 193. Well done you!
Loved this presentation. I really appreciate the study references and strong suggestions supported by prior trials.
I know I will love all five hours of it
Loving this video, biology sure has become even more intricate since the 1990's 😆
Thank you!
Amazing thank you☘
Good podcast!
The real life Clark Kent.
Or Buddy Holly. 😁
Both
Once upon a time there was the TV, aka the idiot box. Now we have UA-cam, featuring people like you. That does still not make YT the genius box, but it's an undeniable benefit to everyone with a least an inkling of curiosity.
5 hours! ..well thats great, because I can just pause and continue again 😊 and I can just listen while doing other stuff, when I'm subscribed to youtube, the phone screen don't have to be on and I have no ads breaks 😊
Thank you.
Love your stuff. Relatively new to Physionic. Am I missing your appraisal of vitamin K2 and plaque? Thanks!
Yes do two episodes please!!!!
I'm curious about the following and would be great to get your input. There are multiple valid sources for each.
- methylene blue, which you did do a short overview of, but nothing since. Considering its benefits, how come it isn't part of your regimen?
- red light therapy looks freakin amazing. I'm only just researching this now. Originally I heard of it when going down the methylene blue road (used in combination to increase the effects), this has a huge amount of research to boast benefits to mitochondrial health. Can you please provide your input?
- boron and borax has some phenomenal research to support bone, joint and general health benefits. It also binds with SHBG resulting in higher free testosterone. It is also associated with lower incidence of prostate cancer and lots of other good things. I would've thought this unsung hero would be of interest to you.
- Just a question on urolithin-a, because it's so damn expensive... can it be produced by fermenting ellegic acid in kefir? I'm curious if there's an easier way to get it into our bodies.
Thanks mate. Your stuff is gold 👍
Thanks! Could you make a video about fermented foods?!
Really appreciate your time and effort on this topic and your insight overall health. Currently taking 5 grams creatinine per day, as an over all health supplement and an ultra running a possible way of reducing recovery time and aid in hydration of the muscles. More to follow 🙏
I know have something worthwhile to watch at lunch for the next week or so.
Ok. Holy crap. This gonna keep me busy for all my commutes this week
this is great. i want to join the PHYSIONIC INSIDERS page i am already on the mailing list. so hopefully next week.
Nice work as always. I always listen to everything you say around creatine and the kidneys. It would be cool if you could talk about testing for albumin in urine or specificity the ACR. When should people get that test? What does it measure? And what could cause transient elevations?
One of my seniors in my lab was working on neuronal ramifications of urolithin A. She was able to prove significant anti-epileptogenic effects exhibited by Urolithin A in Drosophila larvae as well as in adults! It was cool.
Ugh… I had a high creatinine test once that put my eGFR in CKD 3 territory. PCP knew I was muscular and taking creatine but sent me to the nephrologist anyway. Weeks of anxiety and collecting my urine in a jug for 24 hours later and there was absolutely nothing wrong with my kidneys. Wish I had known about these other tests back then so I could have pushed back and saved a lot of money, time, and anxiety. I did get a new doctor after that episode and several other needless CYA referrals.
How far had your eGfr go down? Thx
Great stuff as always. I have LPa in the 250 range so keep an eye on this stuff. My cardioligist first took that test almost 10 years ago. He and his son both have high LPa as well. About 4 years ago he said he THOUGHT maybe it was just a marker and was unsure if lowering it would change anything. Your discussion makes me think it may be more than a marker. The new LPa lowering tests will be interesting to watch. Oh..Niacin got it down to around 219 so not even sure that's significant. Starting Repatha now..we'll see if that effects it at all
Hey man! Fyi, when I was coming up in the 90s, there'd been a recent study at that point that'd apparently actually found hyperplasia in the delts of collegiate swimmers... Thought there would've been a body of corroborating research on that, by now - ??! Wtf... 😮
Great show, great format, great length... subbed. 👍
APPRECIATE YOU
Excellent amalgamation in one video!
I understand Atherosclerosis is very complex I am in the middle of trying to somewhat regress it. If its is interesting to you perhaps you could do a deep dive on Reverse Cholesterol Transport, the substances that support it and its effects on regression of plaque? Love your channel and your knowledge.
Somehow video sounds better and flows better at 1.5 speed.
LONGER ~~~~!!!!!
Finally the Physionic-LotR hybrid we've all been dreaming of.
You said one can not have an epigenetic age that is 20 years younger.than the chronological age, but on the rejuvenation Olympics leader board (absolute leaderboard) i see Dan Sullivan on number one with a chronological age of 78. If my calculation is right his epigenetic age is 78*0.71=55.38. So the difference is 78 - 55.38 = 22.62 years.
What is the process for plaque removal , anything ? I have been taking natto in hopes of reducing blockages ? Ty..
EGFR also goes up with age. As an very active 77 year old who takes creatine, my EGFR is now always too low, even though I am stronger and more fit than 95% of all men. It apparently is assumed, erroneously, that all men my age will have reduced muscle mass. My creatinine levels have come in at 1.2 for about 2 decades, but that level was considered a problem only when my age kept going up [have not found any way to change that!]
Would you ever consider doing an ep on Nephrocalcinosis? I recently got a diagnosis and there’s VERY little info on dos and don’t with this…ie- can I take creatine? How much oxalate should I take in? Etc…
Thanks for covering so many incredible interesting topics. Good luck with your paper. I hope it gets published soon!
고마워~
At the ~30 min mark (more or less) Nick reads a chat comment from a 78-year-old who mentioned he was on a "HFPB diet". Most likely, the commenter was referring to a 'whole food plant-based' diet but he simply typed the abbreviation using the phonetic version of the first word.
This is an excellent podcast. You really need to do an entire podcast shouting your pet peeves and hobby horses. If you feel strongly on a subject, chances are there’s a good reason, right? Damn the Torpedoes, sonny!
Glp -1 leaves the intestinal cell after being stimulated by not food in general but sugar. Then glp-1 travels through the interstitial fluid to the lymphatic sensory neurons where it stimulates the glp-1 receptor. The glp-1 receptor stimulates TRPV1 and TRPA1 on the lymphatic sensory neuron that transduces the electrical signal through the peripheral and central nervous systems. You can read this in the 2020 Berkeley study.
What are that more accurate test for kidney damage ?
Many claim UA-cam algorithms are manipulated, this makes sense. Some may quit if not making enough money. Every now and then they get a HUGE view rate (artificial?).
Then, popular channels will get a dismal view rate. It kinda eqauls out over time.
Cheers mugs and hugs🍻
I add lion's mane and red reishi to my coffee and it gives me a great energy and i would say mental boost.
I'm over 50 so I'll take anything healthy that tastes good and adds to my cognitive function.
So lion mane really help?
Break that algorithm, baby!
Feldman's initial motivation was to deal with his prediabetic state. HbA1c of 6.1. that can be done by diet without resorting to high fat keto and avoid the risk associated with very high LDL. He exchanged one risk for another.
What triggers (or makes) high ApoB versus the other elements of cholesterol?
5 hours? this road trip is about to a learning one
I'm very interested in the inflammation - plaque axis.
Great video. I do have a question on the "5 factors that Extend life" section...did the data indicate which of the factors had the biggest effect?
Sure, they're all bad, I'm just curious as to which of the factors has the strongest negative effect. Is a physically active smoker better off than a sedentary nonsmoker?
On the obesity/autophagy - I have wondered whether this explains why a large study showed decreased risk with AZ or dementia with mild obesity. I seem to remember there is an IGF1 pathway which triggers autophagy which I thought may have explained it.
Will you ever bring up the topic of peptides? E.g. BPC-157?
Something that I need clarification on is what heart disease actually is.
Is it the calcification of the valves? Is it the weakening of the muscle walls? Seems there is a generality covering this area that causes concern, so your clarification would be welcomed.
Last question I have - if all heart attacks are caused by blood clots, how does cholestrol /LDL/VLDL etc play into creating blood clots?
Thanks Nick - sorry if you have answered these in previous content and if so, replying with the links to that content would be appreciated
About the Reversing Atherosclerosis section, with the extended discussion of the need for multivariate correlation analysis... that seems to involve what the famous Dr. Ioannidis, in "Why Most Published Research Findings Are False", derisively called a "hypothesis-generating experiment." That is, the power of the test, which you Physionic did properly bring up, is the probability of avoiding a false negative finding (a finding of no association between an investigated factor and the outcome when in fact there really is one). But there is also the probability of producing a false positive (a type I error). And if you have an analysis that casts about widely in search of relevant factors, the probability of a type I error is increased--- greatly, generally in proportion to the number of factors under consideration (especially if the factors are independent of one another), to the extent that even a seemingly large number of subjects in each factor-defined category would not suffice. If you have a large bag of coins and are searching through them for one that is unfair, that comes up heads more often then tails when tossed, and if to test you toss the coin only ten times, then one out of every eighty-something coins that you toss will produce nine or ten heads *even if all of the coins are fair*... which would be a gross type I error. So yes, if instead of ten tosses of each you do 100 each, that will greatly reduce the probability of error, but... if you sift through a big enough bag of coins (a large enough number of categories into which subjects are sorted) you will still be able to find a fair coin that comes up heads 90+% of the time. See "The Control of the False Discovery Rate in Multiple Testing Under Dependency" by Yoav Benjamini and Daniel Yekutieli for a procedure that reduces the probability of a type I error in these circumstances (which has the unfortunate side effect of reducing the power of the test).
Wow
What was the summary for lowering Lp little a?
Dr. Peter McCullough, (who has focused the last few years on Covid treatment and the mRNA vaccines) has developed a vaccine "detox" protocol which includes Nattokinase, I assume to address blood clots.
I agree with your Chiropractor thoughts even if you dont identify her by name.
What about plaque with a calcium cap? Can they be reduced or best left alone as they are stable?
WHAT ABOUT FISETIN AND D RIBOSE FOR HEART FAILURE?
Great video although you weren't to high on lion's mane 😂.
Thanks for giving your time to help and inform us.
I also appreciate your section on muscle building at age 80. I'm 62 trying to help someone who is 83. I'm sad because he started out strong but is slowing down on his efforts to workout. I can see him slowing down both physically and mentally.
Also we're both homeless, and i can see people taking advantage of him because he's going down hill. People are using him because of his monthly income. He gets mad or brushes me off when I point it out.
At least i have your videos to try to help me explain things to him, when he does listen. I do get him on the treadmill at least once or twice a week. ✌️😊
Epic 🙏👍
Since Allulose appears to stimulate GLP1 release, is it possible that it has some of the same benefits and drawbacks as GLP1 agonist drugs?
What is the website for the coffee mug?
Joeveo.com
Can you do a video on Dr Johanna Budwig's protocol and research?
Can you put a link to your dad's website in the description? 👍
Type "joeveo mug" in search.
What is the website for getting the coffee mug?
Type "joeveo mug" in search.
At 28:38 the word resilient comes to mind