Taurine: Aging Backwards? [Study 193 Analysis]

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  • Опубліковано 21 лип 2024
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    Created with Biorender
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    0:00 - Introduction
    2:16 - Topics Covered
    3:44 - Study & Taurine Background
    5:32 - Taurine Deficiency with Aging
    8:00 - Taurine on Lifespan
    12:02 - Taurine on Body Fat
    14:33 - Taurine on Bone Health
    18:20 - Taurine on Muscle & Brain Health
    20:20 - Taurine on Insulin Sensitivity, Intestinal Health, and Immunity
    26:35 - Taurine & Cellular Senescence
    39:16 - Taurine on Genetic Health
    41:26 - Taurine on Toxicity and Genetic Patterns
    48:18 - Taurine on Cellular Growth & Autophagy Signals
    51:30 - Taurine on Inflammation
    53:45 - Taurine on Stem Cells
    58:18 - Taurine's relationship to Human Health
    1:03:04 - Mid-Point Conclusion/Take Aways
    *******CRITIQUES, RULES, AND NOTES*******
    Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:
    The information provided in this study analysis is limited to the subject and outcomes detailed in the study analyzed [For example: “Consuming sugar (subject) raises insulin (outcome).”] and is not meant to be an all-encompassing education on every health outcome of the subject (unless otherwise stated). I welcome all respectful critique of the study as I may have missed a key detail that you may catch; if that is the case, I will make an ‘Amendment’ to the video and credit you (thank you for making science knowledge better!). Also be aware that I receive hundreds of UA-cam comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, UA-cam auto-deletes links, so I do not see most comments with links attached.
    RULES:
    If your comment is rude, you will be banned without warning.
    If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, your comment will be ignored.
    If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it.
    Please use the following link to submit your critique: bit.ly/PhysionicCritique
    Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

КОМЕНТАРІ • 799

  • @Physionic
    @Physionic  Рік тому +98

    *My recommendation for Taurine* * : amzn.to/3JZx08n
    AMENDMENT:
    I believe I mention that taurine is an amino acid (true) that can be used in functional proteins - this last part is incorrect; taurine is an amino acid, but it not involved incorporated in proteins through protein synthesis.
    Also, on a quick search (I haven’t looked into this deeply), taurine seems to reduce or attenuate increases in cholesterol lipoproteins according to a meta-analysis (DOI: 10.1016/j.ejphar.2020.173533). So, as I suspected, it isn’t much of a worry (I’ll need to confirm this) - some people in the comments of my last video on this topic suggested that taurine levels may be elevated in people who consume more meat (saturated fat), which could have an indirect effect on lipoprotein levels. This is a good possibility.
    *This has been independently lab tested for purity and contaminants; additionally, this is an affiliate link, but I have no relationship with the brand.

    • @SamsonFernendez
      @SamsonFernendez Рік тому +10

      At your convenience of course :) Would you mind talking about nutrient synergies and how to do it in a whole foods manner instead of through supplementation? Not that I'm against supplementation, but just that eating common foods seems easier than picking out high quality supplements and keeping track of dosage and price changes between brands and variations.. Also it's a bit easier when eating animals because most nutrients are passed down from the animal's diet into ours, so would be great if you could help with non-animal based combinations for good/ideal nutrient synergies :) Thanks loads in advance :)

    • @Danny-mg1hu
      @Danny-mg1hu Рік тому +1

      ah yeah! this is what i was looking for!!!

    • @artemisliontas4748
      @artemisliontas4748 Рік тому +8

      Quick question for you if
      you don't mind
      In your opinion can Taurine help with reducing inflammation that is caused by psoriatic arthritis and hyperthyroidism?

    • @danwylie-sears1134
      @danwylie-sears1134 Рік тому +2

      Thank you for including the correction that taurine is not one of the amino acids used in protein synthesis. I scrolled down to comments as soon as I heard the error.
      "Sapiens" as our specific epithet is a Latin adjective in nominative singular form, not an English noun in plural form. There is no such thing as "a Homo sapien".

    • @susymay7831
      @susymay7831 Рік тому +6

      Are you taking taurine yourself?

  • @wheelofcheese100
    @wheelofcheese100 Рік тому +207

    My great, great, great, great grandkids will ask me if I’m on taurine 😊

    • @Physionic
      @Physionic  Рік тому +53

      Hahaha! And you'll jump out of bed with your newly acquired bionic legs and say, "Kids, let's go dunk a basketball."

    • @jmc8076
      @jmc8076 Рік тому +10

      Great attitude. Hope it happens. ✌️

    • @wheelofcheese100
      @wheelofcheese100 Рік тому +1

      @@jmc8076 🙂

    • @tobiaskevorkazito4072
      @tobiaskevorkazito4072 Рік тому +2

      🙏🌸😂

    • @rogerbritus9378
      @rogerbritus9378 Рік тому +3

      By then that will be old news.

  • @JohanLofgren-jc4mh
    @JohanLofgren-jc4mh 10 місяців тому +21

    Thank you for not adding stupid background "music". Please let your channel clean. It is the important message I want to hear. ❤ your education.

  • @edd.
    @edd. Рік тому +163

    Thank you for NOT shortening your videos. I understand we are all pressed for time in this world with work, family's, and social media. Knowledge should not be sacrificed to accommodate a schedule. I feel we should make the time to properly absorb and digest the material. You teach a lot of topics and the depth you cover is important. More importantly is your clear explanation of the material. Please don't change a thing and continue doing what you do!!🙏

    • @jonny9finger
      @jonny9finger 5 місяців тому

      Absolutely I've learnt so much from this man with great data supports the theory. Last 5 months my energy level went thru the roof with his advice.

  • @markbrogan157
    @markbrogan157 4 місяці тому +10

    I’ve been taking taurine the last month
    I’m 60 and I feel as fit now as I did when I was younger
    It’s amazing 🥊

    • @tiz6549
      @tiz6549 2 дні тому

      How much are you taking?

  • @discokillers8674
    @discokillers8674 10 місяців тому +71

    First time on your channel. You explained everything methodically and clearly for the average person to understand. Great job!

    • @Physionic
      @Physionic  10 місяців тому +2

      That's kind of you to say - thank you.

  • @justkidding9751
    @justkidding9751 6 місяців тому +25

    Excellent vlog. I've been taking Taurine for six months and at 64 I'm feeling the benefits. But the best thing I found it useful for is my 8 year old Dog whose epilepsy has returned after 2 years on a medication called Epiphen. The seizures started back in August and as I keep a seizure journal I could see how these seizures have come back gradually until December from the 1st up until the 14th she suffered 16 seizures. After hearing it helps with brain dysfunction and is ok for dogs I gave my dog a dose and since the 15th December she hasn't had 1 single seizure. I have documented this and done a UA-cam vlog confirming how it has helped her and I'm doing weekly updates. Unlike the Epiphen the Taurine may even extend her life and it's beneficial for her overall health which is more than I can say for the Epiphen. Anyone wishing to hear the progress on my findings can see it for themselves on my UA-cam channel (Just Kidding) yes that's the name of it.

  • @birage9885
    @birage9885 Рік тому +142

    My, my, my, how time flies. I remember Pearson and Shaw talking about taurine back in the 80s, saying that someday this would be the new vitamin C. I have been using taurine that long, and what was an inexpensive nutrient will turn into the new darling, become scarce, and go up in price. The dark side to these studies. The GlyNac study did the same thing.

    • @jackbuaer3828
      @jackbuaer3828 Рік тому +27

      If Durk Pearson looked like he was in 20s ,30s, 40s or 50s, I might say that he is on to something that turns back the clock. Based upon visual appearance (and that counts for a lot in my book), his regimen, if effective at all, would be modest at best.
      People are quick to discount visual appearance as a marker of aging, but it typically and readily easily allows us to distinguish between young and old (if no cosmetic procedures). There is no doubt about this. A 50 year old looks way different than a 20 year old. If one could truly slow aging, they're likely going to slow the visual markers as well blood and other biomarkers.

    • @midnightsnack1306
      @midnightsnack1306 Рік тому +23

      @@jackbuaer3828I’m sure a lot of aging folks would certainly want to look like they are in their twenties forever but for people me I just want to be strong and healthy enough that I can still play tag with my grandchildren when the day comes.

    • @birage9885
      @birage9885 Рік тому +3

      @@jackbuaer3828 Ha, ha, I can't argue that about their appearance. However, I think P&S did other things that sabotaged their ability to age slowly. Of course, at the time, science was limited on nutrient intervention, etc. Finally, if you use that as a determining factor to validate the study on taurine, it looks like taurine isn't as good as they are saying, lol.

    • @jackbuaer3828
      @jackbuaer3828 Рік тому +9

      @@birage9885 I want to clarify that I was in no way meaning to denigrate their appearance. I was only trying to say that they look their age. There is nothing wrong with that. Most people look their age or worse. I was also trying to make the point that it is likel difficult to biohack aging through extreme efforts.
      So far I am not aware of a miraculous regimen or supplement that reduces the visual impact of aging. We see some Asian people that look much younger than their age, but many of them are not following a single regimen.
      If at some point we get a miracle pill or miracle regimen, I expect it will cause "across the board" improvements visual appearances among those over 50 presuming that have started the pill or regimen in their late 20s, 30s or 40s. Some people that look much younger than their age in their mid 50s or early 60s claim to do nothing out of the ordinary.

    • @damien2198
      @damien2198 Рік тому +3

      @@jackbuaer3828 " I was only trying to say that they look their age" They were looking awful for their age

  • @Michael-oj5pr
    @Michael-oj5pr 11 місяців тому +58

    Awesome you are doing this, finally good scientific videos. I have a physics background and really appreciate the time and effort you put in this. We need more people like you!!

    • @Physionic
      @Physionic  11 місяців тому +3

      Thanks, Michael!

  • @marccas10
    @marccas10 Рік тому +368

    I knew an old guy, thin as a rake and he was always chugging Monster energy drinks. I have to admit to being worried for the guy. Little did I know that he was immortal.

    • @garyssimo
      @garyssimo Рік тому +35

      33 grams sjger per 8 ounces will ruin his health.

    • @transkryption
      @transkryption Рік тому +31

      @@garyssimo sjger is that the new street drug from Prague? or is that cake?

    • @user-fy7ri8gu8l
      @user-fy7ri8gu8l Рік тому +18

      @@garyssimo Not really. Compared to what? What is his TDI for sugar? How active is he? 33g is basically jack shit for moderately active people that work out and do cardio during the week. It's a lot for S.A.D. metabolic disorder having American couch potatoes that are the problem. A person with a healthy metabolism really needs 60-90g per hour of zone two work out alone, a can of this will do nothing to them, American couch potato will need to shoot themselves with insulin just looking at it.

    • @kathybrown8533
      @kathybrown8533 Рік тому +5

      recommended dosing for a 65 year old active female

    • @kathybrown8533
      @kathybrown8533 Рік тому +7

      can this supplement help someone w/ cancer?

  • @BakamonNO
    @BakamonNO Рік тому +49

    Thanks to Physionic I'll be an amateur molecular medicine scientist soon. Mom will be so proud of me 😃

    • @theantiqueactionfigure
      @theantiqueactionfigure Рік тому +1

      Have you started your UA-cam channel yet? ❤ 😂

    • @BakamonNO
      @BakamonNO Рік тому +1

      @@theantiqueactionfigure lol. No I'm not as charming as Physionic. Maybe in another life😅

    • @Amandaetutor
      @Amandaetutor 11 місяців тому

      A new skill

    • @Amandaetutor
      @Amandaetutor 11 місяців тому

      That’s how I started 30 years ago - I now include all this in my regular teaching - they love it
      And it keeps me interested

  • @jmc8076
    @jmc8076 Рік тому +77

    Only few min in and gave thumbs up just on quality of research and effort to organize data and facts for viewers. Brilliant. Thx Nic.

  •  Місяць тому

    I’m so glad you didn’t shorten the video. Every second was time well spent. When I saw the length of it I thought I should just watch the intro and then listen to the rest during my daily walk. Once I started watching, I couldn’t stop. The visual information you provided was essential in helping me understand everything you said. Thank you for the time you spent creating this video.

  • @justkidding9751
    @justkidding9751 9 місяців тому +4

    This was a great breakdown of this study and you covered it well, and you put it into layman terms that we can all understand. You provide good evidence and as a 64 year old with a deteriorating spinal condition I found it encouraging and have now included Taurine into my diet. I have in the past 5 years made many changes in how I look after myself and the first thing I did was to stop smoking, then I worked on my weight and completely changed my diet and have been a pestcaterian for 2 years, I have gone from 18.4 stone down to 13 stone and I have a daily exercise routine. I include kefir in my diet as I understand the importance of gut health. I have managed to come off all my medications which there were many including Statins and blood pressure medication, and this vlog has convinced me that this is really an essential supplement that all over 50s should consider. Thank you for this breakdown on Taurine I found it encouraging. Great channel you're a good man. Thank you, Thank you.

  • @zonkedoutzygote
    @zonkedoutzygote 10 місяців тому +13

    By far the best channel I've found for indepth explanation of studies. Thank you so much for taking the time.

    • @Physionic
      @Physionic  10 місяців тому +1

      Thanks, Jenna!

  • @fidelogos7098
    @fidelogos7098 3 місяці тому +4

    When I was in college, molecular biology was a NEW major! That was a lifetime ago, and though I eventually wound up in computer science as a career, I still love to hear "trash" talk from biology people. I'm also interested in it because I'm getting old and looking for the Fountain of Youth. I've been taking Taurine for about 3 months now, but haven't yet noticed any significant changes. I'm thinking about increasing my dosage. Thanks for this and good luck with your studies.

  • @spockboy
    @spockboy Рік тому +17

    Excellent work! Appreciate the time stamps for future reference.

  • @Wide_awake316
    @Wide_awake316 8 місяців тому +1

    Thank you for not shortening these videos ❤️

  • @pungar12aa
    @pungar12aa Рік тому +74

    I have taken 7 grams of taurine for over 7 years to renew my lungs from smoking. I can now run without any issues, wheezing is gone, no more trouble feeling like I'm not getting enough air. I still smoke when I'm having cocktails. No apparent side effects.i suppose I should add that it has been 7 grams (7000mg) a day

    • @tullyapx500
      @tullyapx500 Рік тому +20

      I quit smoking after 42 yrs of smoking. I didnt take anything, but I run regularly and only had wheezing and out of breath issues when I started running. I have no obvious ill effects from smoking. All we can offer is our own anecdotal evidence, and both ours have the same outcome with or without taurine.

    • @supernice_auto
      @supernice_auto Рік тому

      you should just quit smoking- it's disgusting

    • @rogerbritus9378
      @rogerbritus9378 Рік тому +2

      ​@@tullyapx500You don't say how long ago you quit. Give it some time and a different result could appear. Make sure you test your lungs frequently for abnormal growths!

    • @pjaworek6793
      @pjaworek6793 Рік тому +5

      Interesting comments guys. Nick should do a video on respiratory issues. So much going on from alcohol effects on lungs, evali, covid, supplements like NAC, nmn, vitamins/minerals, omega3, ginseng, and now taurine.

    • @Utoko
      @Utoko Рік тому

      Good for you! but anecdotes can be misleading and throw you of the fast of truth seeking fast. You could share where you based your assumption that it would renew your lungs on.

  • @terrywbreedlove
    @terrywbreedlove 9 місяців тому +6

    Day 2 on 2000mg Taurine. 59 year old male overweight with high blood pressure. I do lift weights three days a week and walk a little most days. I also take Creatine which has been very helpful in the gym. Hoping to see good results with Taurine. Thank you for the very informative video.

  • @christinamilioni6325
    @christinamilioni6325 Рік тому +5

    Great content as always!!

  • @Peter-x29
    @Peter-x29 11 місяців тому +2

    That's absolutely great channel! Thank you so much for your work

  • @kathyfann
    @kathyfann Рік тому +1

    So glad I found your channel this is extremely interesting. Thank you!

  • @danschweri
    @danschweri 7 місяців тому +1

    Incredible work you put in - thank you!!

  • @eddietrujillo7914
    @eddietrujillo7914 10 місяців тому +10

    Historical I’ve been skeptical of taurine supplementation, but this new research has my interest. Excellent review of this research 👏🏾

    • @EdT.-xt6yv
      @EdT.-xt6yv 7 місяців тому

      Don't forget exercise & eating greens ,,,

  • @mboiko
    @mboiko Рік тому +9

    Yes, it's VERY important to follow LDL/HDL results using Taurine in further videos.

  • @LA_Viking
    @LA_Viking 11 місяців тому +6

    I'm watching this particular video for the third time to glean the maximum amount of information contained herein. I am a classically trained epidemiologist and tend to dismiss...or outright laugh at...most medical channels here on RubeTube. You have a winner and a subscriber.

  • @wojciechkrupa9288
    @wojciechkrupa9288 11 місяців тому +2

    really awesome video man, i really appreciate your work.

  • @MyLove-uj8zi
    @MyLove-uj8zi 11 місяців тому +4

    I appreciate the detailed videos. I appreciate your hard work. Making it understandable for the regular guy. Thanks.

    • @MyLove-uj8zi
      @MyLove-uj8zi 11 місяців тому

      Or gal..lol.

    • @Physionic
      @Physionic  11 місяців тому +1

      My pleasure - a labor of love.

  • @ericbyrd5393
    @ericbyrd5393 11 місяців тому +52

    Dr. Verhoeven, thank you for your work here. I've been supplementing taurine for about 10 years now, buying it in bulk packages of 1 kg and mixing it in drinking water in gallon jugs, with large quantities of MSM. My daily dosage is about 2.5 g of taurine. I started doing this only for this one reason: I had read that in places like Japan, where people are famous for their longevity, one of the isolated factors for this was that their diet was high in taurine. I didn't really learn much of the details until I saw your work.
    But there is one thing that troubles me. I also powerlift regularly, so building and retaining muscle mass is a priority for me. And apparently, taurine supplementation short-circuits the end of the mTOR pathway. I know there are several paths to activate mTOR, but apparently taurine suppresses the very end stage, of this special protein that is responsible for stimulating muscle protein synthesis, so it appears that regardless which way you approach mTOR, taurine suppresses muscle protein synthesis.
    There are several known compounds that do this, that are all associated with longevity and anti-aging: rapamycin (whence comes the name "mechanistic target of rapamycin" or "mTOR"), resveratrol, epi-gallo catechin gallate, etc. All are known for improving longevity, but suppressing mTOR. Apparently taurine supplementation has the same exact effect: it improves your longevity generally, by delaying cell senescence and the subsequent buildup of "zombie" cells, but it also suppresses the buildup of muscle mass. If this is right, it's very disappointing: if I want to retain muscle mass, I have to live with the normal aging pathways. If I want to delay aging, I have to live with my powerlifting not yielding one of the most desirable rewards of that work.
    Do you know of any way to get around this?

    • @rubensonorio8805
      @rubensonorio8805 11 місяців тому +4

      Thanks for sharing 😅

    • @jac6541
      @jac6541 11 місяців тому +12

      I’m very interested in the answers to this.

    • @justdave1
      @justdave1 11 місяців тому +4

      If someone has a workaround, I'd like to see it myself. Until then the best path may be one of lowered expectations. It seems like living longer has more benefit. I suspect you have a lot of muscle allready, more than enough to take you comfortably into older age. I'm 72 and weak as a kitten, which I am fighting (with myself) to change. I've lost 80 pounds and time to work on some muscles. I need some but not really that much. I think Taurine will help me in general and not interfer with normal body building or shaping. If your one of the powerbuilding elite then your needs are specialized, I'd ask a professional somebody for advice.

    • @Lulu-kt6gr
      @Lulu-kt6gr 11 місяців тому +5

      Is it a significant amount of suppression? Meaning, would it keep a person from gaining bulk or would it keep the muscle from growing at all? As a woman I’m only interested in maintaining firm muscles that are also strong

    • @miriaml.150
      @miriaml.150 11 місяців тому +14

      In regard to the dose you are supplementing with for taurine you may need to pull back. There's something called a hormetic effect. That means that something is more effective taken in a smaller amount and can actually harmful taken in a larger amount. I would investigate that as a pertains to taurine.
      (Dietitian since 1982)

  • @TheEbulla
    @TheEbulla Рік тому +6

    Don't shorten your videos. Wonderful lecture.

  • @cdkslakkend5742
    @cdkslakkend5742 8 місяців тому

    Wow, Excellent presentation. I thank you for taking the time to put this together. Incredible information.

  • @TinselDoll
    @TinselDoll 5 місяців тому +2

    I'm just so into these lectures of yours, Verhoeven.
    As a neurologist, all this is so fascinating to me. Immeasurably more fun than allopathic medicine.

  • @andrewj2411
    @andrewj2411 11 місяців тому +1

    Thanks for a great video. I really like the detailed, longer format.

    • @Physionic
      @Physionic  11 місяців тому

      Thanks, Andrew.

  • @KhalidKhan-sp9yq
    @KhalidKhan-sp9yq 11 місяців тому +1

    Mightily impressed Dr. Sahb. Im your newest subscriber

  • @zoey907
    @zoey907 3 місяці тому +1

    Please never stop making videos!! I just found you today & took my 1st Taurine!! (60)....Love how you take your time and break it down !!the longer the video the better!!!♥️

  • @kathyfann
    @kathyfann Рік тому +1

    Thank you I love this wonderful video! We appreciate the Information!

  • @iamcookbook
    @iamcookbook 8 місяців тому +1

    awesome video, love the details you go into, keep your videos long!

  • @petermichalantos5038
    @petermichalantos5038 11 місяців тому +3

    You rock, Nick. Thank you. Your breakdown is perfect. As a newbee, I am looking forward to the rest of your content. No more researching for me. cheers champ.🏆

    • @Physionic
      @Physionic  11 місяців тому

      Thank you, Peter.

  • @Heirloom-HavenTeam
    @Heirloom-HavenTeam 3 місяці тому +2

    Love this hardcore science. Excellent job explaining, and so patient with us! Thank you!

  • @pocketsuperman7108
    @pocketsuperman7108 9 місяців тому +8

    I am 51 and take Taurin 2 grams daily for 6 months. My sleep got better, my mood is like more balanced and i have more energy keeping low heard pace.
    I don‘ t know the reason, but my doktor seing my blood work, regading my LDL cholesterol asked me if i take any medicine. After my negative answer he said, that he has never seen so low cholesterol lebels on individual with my age without taking any pills.
    Regards

    • @Mikolas649
      @Mikolas649 Місяць тому +1

      Low TC And low LDL, contraindicated for longevity, despite what centralized doctors tell you

    • @hfctab3799
      @hfctab3799 18 днів тому +1

      Not so, can be the sign of efficient hormone activity. As high cholesterol is one of the signs of low thyroid function

  • @JimJim-md8ll
    @JimJim-md8ll 6 місяців тому +3

    Awesome presentation! You answered many of the questions I had as I've been taking Taurine for awhile now. Can you do a presentation on vitamins D3and K2 with respect to the circulatory system?

  • @nvrancher
    @nvrancher 4 місяці тому +3

    Started taking taurine and creatine because of you in depth reporting. Looking at glynac. I see you are somewhat ambivalent about glynac. Back ground, 74 yr old, went from sissy squats to 280/300 pound 3 set/20 rep squats. Thanks for all your help in understanding supplements.

  • @carlogheller6779
    @carlogheller6779 4 дні тому

    I listen to your information while doing a work out at my gym! Not a problem!!😊

  • @clarahaylock8776
    @clarahaylock8776 Рік тому +1

    Thank you so much for all the knowledge

  • @RobertaPeck
    @RobertaPeck Рік тому +9

    I love love love you as my UA-cam professor!!!

  • @Nyonide
    @Nyonide Місяць тому +1

    Great video!! And it is great that you stay away from advertisments

  • @tfokeefe
    @tfokeefe Рік тому +11

    You have the most unusual talent to explain things very clearly, I am so glad I found you , I hope you expand your repertoire! 😍😍😍😍😍

  • @richglaser4566
    @richglaser4566 11 місяців тому +1

    Thank you for this video. You a a brilliant man. Very interesting video

  • @citypsychotherapy3968
    @citypsychotherapy3968 8 місяців тому +2

    A gastrointestinal transit test is a diagnostic procedure used to assess the movement of food and waste through the digestive system. It is often employed to diagnose conditions such as constipation or gastrointestinal motility disorders. The test involves tracking the passage of a substance (such as a radioactive marker or a capsule containing markers) through the digestive tract. The transit time is then measured to evaluate the function of the digestive system.
    To detect an improvement in a gastrointestinal transit test, you would typically look for a decrease in transit time. A faster Transit Time: If the transit time of the substance through the digestive tract decreases, it suggests that the motility of the gastrointestinal system has improved. This can be an indication of improved muscle contractions and coordination in the digestive organs.
    Good guess Nicolas!

  • @westcoastswingmusic
    @westcoastswingmusic 9 місяців тому +1

    You are my favorite UA-camr! ✨️

  • @vicvin64
    @vicvin64 11 місяців тому +12

    The algorithm is lagging i love this type of content and have never heard of you until now.
    I started dabbling with taurine 20 years ago when i was an idiot that took clen to get summer lean and heard Taurine prevents clen muscle cramps. The cramps were for real. Taurine seemed to help. I forgot about Taurine until a few years ago when i heard it helped with bile so i took it when i noticed digestive issues.
    Cut to a year later i read that taurine helps with anxiety by converting glutamate to GABA and potentially by reducing blood pressure which is part of the anxiety cycle ; feeling physiologically excited (heart rate hot face) thinking others notice this which is furthering nervousness. Anyways i had always been someone who lived with anxiety like literally sweating if someone i didnt know well was close to me talking to me for long enough to elicit this response. But i noticed as i read about this plausible taurine mechanism that i had not gotten that anxiousness since regularly taking taurine. So theres that.
    It also helped my sleep onset which used to take hours sometimes likely from anxiety over thinking when trying to sleep and taurine seems to just calm the mind it's amazing for so many things.

  • @kathydreiling6406
    @kathydreiling6406 10 місяців тому +12

    Fascinating research! If I understand this correctly, Taurine has so many benefits except for muscle development where it can be a negative side affect if trying to build muscle. If that is correct, then no elders should take this. I'm 71, petite, female and have been supplementing a 1000 MG. I feel like I have lost muscle not gained, even though I lift heavy weights. A clarification would be appreciated. Thank you, Nick, I love your videos and learn so much from you. PS: and you sure are easy on the eyes. 😊

    • @lovemissle
      @lovemissle 10 місяців тому

      Oh noooo😢. I just ordered a bottle from Amazon. 1000mg is that what I should take?

    • @lighthealerastrid1465
      @lighthealerastrid1465 8 місяців тому +1

      @@lovemissle Oops so did I… the powder. Also 71 like Kathy and enjoying muscle hypertrophy.

    • @kiranbala90
      @kiranbala90 6 місяців тому

      Powder is cheaper to buy than capsules.

    • @paulharrisonadventuregearm5457
      @paulharrisonadventuregearm5457 3 місяці тому +2

      Taurine is fine for muscle development.

    • @paulharrisonadventuregearm5457
      @paulharrisonadventuregearm5457 3 місяці тому

      ​@@lighthealerastrid1465dhea is your answer among a range of vitamins. In females a tiny amount of dhea is highly anabolic in older females

  • @daviddestrebecq9806
    @daviddestrebecq9806 Рік тому +1

    Wonderful review.A good format .

  • @exxzxxe
    @exxzxxe Рік тому +2

    Excellent presentation!

  • @johnnyb1368
    @johnnyb1368 Рік тому

    I found this on Immunophenotyping, hope this helps.
    Immunophenotyping detects the presence or absence of white blood cell (WBC) antigens. These antigens are protein structures found on the surface or interior of WBCs. Typical groupings of antigens are present on normal WBCs. Atypical but characteristic groupings are seen with specific leukaemias and lymphomas. This allows immunophenotyping to be useful in helping to diagnose and classify these blood cell cancers dependent on the particular pattern of antigens present or absent.

  • @zencontroller
    @zencontroller 11 місяців тому

    Good info brother... Thankyou for the effort!!!!

  • @joanhui2041
    @joanhui2041 5 місяців тому +1

    Thank you for this informative video, very interesting.

  • @Cletus_the_Elder
    @Cletus_the_Elder Рік тому

    This is the most thorough treatment I've seen here. I am considering supplementation, but wary of the sedative effects. Some report lethargy with taurine supplementation. I had a horrible experience with choline. Even taking a small amount of choline made moderately challenging tasks herculean.

    • @criticalbil1
      @criticalbil1 11 місяців тому

      Choline didn't seem to do anything for me either, including soy lecithin and DMAE. Taurine is intriguing me though.

  • @lsh6832
    @lsh6832 6 місяців тому +1

    No need to shorten!!! Perfect concept!! Not average

  • @osis1k
    @osis1k 5 місяців тому +1

    From a fan of orthomolecular medicine I love this delivery info.

  • @Battery-kf4vu
    @Battery-kf4vu Рік тому +7

    Very well explained, thank you very much.
    Concerning the table with the colors at 1:10, it seems that overall hypotaurine has more blue than taurine, so I wonder, how is taurine converted to hypotaurine? Is is via an enzyme? Could the conversion be increased?

  • @mikecraig5269
    @mikecraig5269 10 місяців тому

    I am so interested in your video-release and consider them to be delivered at an assimilable/laymen's pace. This topic is of great interest to me because, prior to your productions, I have only met with derogatory feedback about this supplement. Looking forward to gaining more knowledge through your releases.

  • @pierrejeanes
    @pierrejeanes Рік тому +7

    Great content as always👍

  • @ragingagainsttime6812
    @ragingagainsttime6812 Рік тому +3

    This is brilliant. Thank you

  • @joecool7165
    @joecool7165 Місяць тому

    Always learn something from you. I’m taking it now been about five days.

  • @Bellasafari
    @Bellasafari Рік тому +10

    Taurine is used greatly by the brain> GABA, the heart and the thyroid. I have been rx taurine for dysfunctional thyroid and elevated LDLs, anxiety…ETC for years. Scientific publications have documented all the above-- years ago. When it makes it to MSM/textbooks etc, it is 5-10 yrs old info if not older.

    • @lostinthoughts5645
      @lostinthoughts5645 9 місяців тому

      So did you manage to significantly reduce anxiety and is your thyroid ok now? May I ask what is your dosage? Thx!

    • @Bellasafari
      @Bellasafari 9 місяців тому

      @@lostinthoughts5645 I am a doctor that prescribes it for these issues. Yes it works along with much other support. Dose is dependent…

  • @debmanrique6466
    @debmanrique6466 Рік тому +63

    Excellent info, thanks! Btw, bone mass matters way before 80 yo. Women start losing bone density in their 50's or even earlier.

    • @theantiqueactionfigure
      @theantiqueactionfigure Рік тому +3

      They don't test men for bone density until it's too late. Don't ask me how I know!

    • @johna5484
      @johna5484 11 місяців тому +9

      @@theantiqueactionfigureI’m a man and started getting tested in my 40’s. You have to ask. You are your own health advocate. Nobody else really cares about your health .

    • @Hack3r91
      @Hack3r91 11 місяців тому +5

      Bone density peaks in your 20s, starts declining in your 30s and plummets from your 40s onwards

    • @bencyber8595
      @bencyber8595 9 місяців тому

      yes, true

    • @TheMommom8
      @TheMommom8 8 місяців тому

      Excellent presentation! A question..I normally always have a low white blood count , do you think taurine supplementation would be a problem? Thank you for all the time and work you invest in these podcasts!

  • @carolematar3760
    @carolematar3760 Місяць тому

    Love your channel and your information dissemination

  • @jayalanlife5926
    @jayalanlife5926 Рік тому +2

    Cool work, your love subject is obvious and somewhat contagious

  • @That0therGirl
    @That0therGirl 8 місяців тому +1

    Great video. Extremely interesting.

  • @keithstropp6593
    @keithstropp6593 9 місяців тому

    Absolute reliable information. Top grade tour. thanks!

  • @tobiaskevorkazito4072
    @tobiaskevorkazito4072 Рік тому

    Great topic, my interest is so piqued 🙏🌸

  • @brainwithani5693
    @brainwithani5693 Рік тому +32

    I'd love to see a video on Thiamine- there are a lot of claims of it's health benefits in high doses and the different forms of it. Specifically TTFD and benfotamine.

    • @amylee9
      @amylee9 11 місяців тому +3

      It helped my young son improve his stutter significantly. The effects would wear out but I would just supplement again while also trying other methods. He’s now a teen and no longer stutters.

    • @Bazza5000
      @Bazza5000 10 місяців тому +2

      I hear a lot of people talking about that stuff, but don't know much about it. I am desperate to heal my gut health.

    • @brainwithani5693
      @brainwithani5693 9 місяців тому

      @@Bazza5000 check out Elliot Overton

    • @brainwithani5693
      @brainwithani5693 9 місяців тому

      @@amylee9 wow that's great!

    • @jenniferboehm514
      @jenniferboehm514 2 місяці тому

      Benfotamine helped tremendously for my essential tremor for about a month. For some unknown reason, it stopped working. Frustrating. Finding that sweet spot of dosing has been difficult.

  • @dlg5485
    @dlg5485 9 місяців тому +1

    I don't currently supplement with taurine, although I am considering it. I found the section on WBC quite interesting because my recent lab results showed a low WBC which was initially concerning to me. However, I did some research and discovered that a slightly reduced WBC count is an indication that your immune system is likely optimized, i.e. your white blood cells aren't being called upon as much to fight infection and therefore are naturally lower. Lower WBC is indeed an indication of reduced inflammation. I should mention that I am very healthy... I do IF, exercise daily and take high quality immune boosting supplements, so a low WBC makes sense for me.

  • @Laura-gx9jr
    @Laura-gx9jr 4 місяці тому

    Just found your channel. Fantastic breakdown, Nick. 👍👍👍 Subscribed!

  • @GaryHost-qs9pg
    @GaryHost-qs9pg Рік тому +6

    Thank you for making this content physionic

    • @Physionic
      @Physionic  Рік тому +2

      Thanks for watching, Gary. :)

  • @voltrading4966
    @voltrading4966 9 місяців тому

    Thanks for another great video!
    Note that despite all the positives for hypotaurine the study doesn't discuss hypotaurine induced colorectal cancer which is well researched elsewhere.

  • @simonfoo8684
    @simonfoo8684 12 днів тому

    Thank you. Very clear explanation.

  • @azdhan
    @azdhan 6 місяців тому

    Excellent! Many thanks for sharing

  • @GIBZ1966
    @GIBZ1966 2 місяці тому

    It is pleasure to listen to your lectures.

  • @rachelw1624
    @rachelw1624 Рік тому

    Loved it and thank you👍👍🙏

  • @glenwoodfirewood
    @glenwoodfirewood Рік тому +11

    Very interesting study. Nice work on presenting. I think the bone mass of the samples including humans would be further increased with k2 supplementation. I am certain this was not in the animal feeds.

    • @Nobody-Nowhere
      @Nobody-Nowhere Рік тому +1

      And cutting out meat, as meat consumption decreases bone mass and increases osteoporosis.
      "Several studies indicated that frequency of meat consumption was associated with bone mass and fracture rates in humans"
      As meat comes with antinutrities like purines, that are acidic and to combat this body leaches out calcium from the bones to neutralize the acidic environment.

    • @theantiqueactionfigure
      @theantiqueactionfigure Рік тому +3

      ​@@Nobody-Nowhereoh please😂

    • @johna5484
      @johna5484 11 місяців тому

      @@theantiqueactionfigurego read it’s true. Same with milk.

    • @shar3882
      @shar3882 9 місяців тому

      Animals such as mice are able to produce their own vitamin k2 in sufficient quantities from the vitamin k1 in their feed.

  • @isa-manuelaalbrecht2951
    @isa-manuelaalbrecht2951 Рік тому +2

    Nope no shortenings, much much too important what we can learn and whst you've to say..thanx and greetings from Switzerland - Isa 🤩

  • @susymay7831
    @susymay7831 11 місяців тому +1

    Good timestamps!❤❤❤❤❤

  • @lassereinhold9439
    @lassereinhold9439 Рік тому +12

    I'm wondering what the taurine contents is in the lab food for the mice, fish and worms are. I know they use some form of standardized food pellets. But if these are deficient in taurine compared to the *natural* foods of the animals out in wild nature, then no wonder that supplementation has big effects. It's like: Give 100 mice food pellets with no vitamin C, and give other 100 mice food pellets + vit. C supplementation. Now watch how all mice in the first group die young, and conclude that "vitamin C supplementation doubles life span". But taurine is found in meat, so maybe baseline intake is already optimal in human?

    • @jb_1971
      @jb_1971 8 місяців тому

      You raise a valid point, but note that there was an added benefit to a higher dose of taurine, which would be impossible to get from food alone.
      Also, I'm not a mouse expert, but I don't think mice have much taurine in their natural diet.

  • @cthornton523
    @cthornton523 Рік тому +2

    Please do not shorten the vids. I want ALL the data. Thx Nic.

  • @walterwjr947
    @walterwjr947 11 місяців тому +5

    Is there any indication as to where Taurine is _used_ in the cells? What _organelle?_ I suspect the mitochondria, but I took cell biology back in 1974. If it is know where Taurine is used, how was this determined?

  • @phillustrator
    @phillustrator Рік тому +7

    Man, I'm binging on your stuff.
    If you get a chance to take a look at the omega 6/omega 3 ratio claims, I'd be very grateful.
    My intuition is that it's nonsense, but I would love to see a thorough break down by someone like you.
    Cheers!

    • @Nobody-Nowhere
      @Nobody-Nowhere Рік тому +3

      It is nonsense, there are no real studies about it.
      Both, omega 6 & omega 3 are essential fatty acids, and both are anti inflammatory even in large quantities.
      If you are interested in quality content, check out channel named "nutritionmadesimple".

    • @limitisillusion7
      @limitisillusion7 Рік тому +1

      I'm not convinced yet, but I have seen the video from NutritionMadeSimple. I would like to see more research. I have no problem with corn oil and inflammation in moderation. But if I eat a ton of it, it does cause me inflammatory issues. But I am more inclined to credit that inflammation to the caloric surplus that comes with eating a whole large pizza drenched in corn oil. Eating at caloric maintenance and exercise can work wonders for all this chronic inflammation, even if you're eating like crap.

    • @phillustrator
      @phillustrator Рік тому +1

      @@limitisillusion7
      Buddy, the majority of the fat in pizza comes from cheese, the majority of which is saturated.
      Sounds like you really want to blame corn oil.

    • @limitisillusion7
      @limitisillusion7 Рік тому +1

      @@phillustrator No, I used to eat pizza without cheese and the same effect occurred when I ate a whole pizza. I also get inflammation from eating too much fried potatoes or lean fried chicken. I don't want to blame corn oil. In fact, I love the stuff. I'm not convinced is all. I think inflammation is a phenomenon that we haven't quite narrowed down yet. My inflammation also decreased when my omega 6:3 ratio dropped to ~5.

  • @anirecapped.
    @anirecapped. 11 місяців тому +4

    Hey, by the way, did you see Dr. Peter Atiia's article on this Taurine study?? He makes some compelling arguments as to why Taurine supplementation may not be as effective for us humans as compared to mice and monkeys, would love to know your views on that. Wish I could share the link.

  • @openureyes
    @openureyes 7 місяців тому

    Amazing info by a well spoken man

  • @velikanskaglava2087
    @velikanskaglava2087 Рік тому +2

    44:45 they switched it because it is a similarity tree, dendrogram, ordered by similarity, look on top of each stack image. Taurine works better on muscle and brain than liver (taurine aged liver is more similar to aged, than young).

  • @TheWadetube
    @TheWadetube 11 місяців тому

    This was great information and I appreciate you bringing so much detail out. I wonder, however about hypotourine...? It does not increase the risk of kidney disease, which my mother has. Can I ask for it at the health food store?

  • @TheTommyOhh
    @TheTommyOhh Рік тому +2

    Can you explain the glucose portion and specifically in regards to low blood sugar? I have hypoglycemia but all studies reference seem to lokk at hyperglycemia leaving my specific issues out of the conversation.

  • @kathleennorton2228
    @kathleennorton2228 11 місяців тому +3

    L Taurine is the compliment of glutamine.
    If you are sensitive to MSG taking L Taurine can balance out MSG when you feel you have ingested too much of it. MSG is slathered into so many processed foods, even under different names.
    Truth in labeling is an org that is educational on how much MSG people are actually eating under different labeling.

  • @stephanemoyen5521
    @stephanemoyen5521 21 день тому

    Great job! What is missing is how much Taurine depending on the age and the looked for benefits. That said congratulations for the best available videos on the topic.

  • @HappyEddyMcGuire
    @HappyEddyMcGuire Рік тому +3

    Great video! Can you go next level breakdown on oxalates? And then the link - bad link - between it and curcumin, which was a bummer to hear from a great oxalates doc video on YT. That's me asking. Who the hell am I to ask? I don't know, I'm just asking, you don't have to get pissy about it. A nod to your humor, which is awesome!

  • @askingwhy123
    @askingwhy123 11 місяців тому

    Thank you for not making your videos shorter 🎉

  • @pianogal853
    @pianogal853 Рік тому +13

    Interesting that the yeasts are not affected by the taurine. Good to know that these critters in our bodies wouldn't be growing with human supplimentation

    • @larsnystrom6698
      @larsnystrom6698 11 місяців тому +1

      @susymay7831
      I guessed that had something to do with that yeast is single celluar, and Taurine works on multicelluar organisms.
      Something to do this, perhaps:
      "Since taurine is a key organic osmolyte in most cells, the possibility that the effects of taurine on ion transport could be related to its osmoregulatory activity."

    • @walterwjr947
      @walterwjr947 11 місяців тому

      Adding my two pennies here: that particular strain of yeast did not show a measureable change, that does not speak for all yeast strains. Secondly, yeast are "weird birds", neither animal or plant in nature. And for sure they are not animal. They are single cell, but most do have multi-cellular properties.

  • @larryfromchicago6526
    @larryfromchicago6526 11 місяців тому +5

    Optimal dosing information should offered in the public segment.

    • @smarzig
      @smarzig 3 місяці тому

      Left out purposely